keyword
MENU ▼
Read by QxMD icon Read
search

acinetobacter baumannii

keyword
https://www.readbyqxmd.com/read/28105270/1-2-4-triazolidine-3-thiones-as-narrow-spectrum-antibiotics-against-multidrug-resistant-acinetobacter-baumannii
#1
William M Huggins, Bradley M Minrovic, Brendan W Corey, Anna C Jacobs, Roberta J Melander, Roger D Sommer, Daniel V Zurawski, Christian Melander
With only two new classes of antibiotics developed in the last 40 years, novel antibiotics are desperately needed to combat the growing problem of multidrug-resistant and extensively drug resistant bacteria, particularly Gram-negative bacteria. Described in this letter is the synthesis and antibiotic activity of 1,2,4-triazolidine-3-thiones as narrow spectrum antibiotics. Optimization of the 1,2,4-triazolidine-3-thione scaffold identified a small molecule with potent antibiotic activity against multiple strains of multidrug-resistant and extensively drug-resistant Acinetobacter baumannii...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28102683/key-structural-elements-for-cellular-uptake-of-acinetobactin-a-major-siderophore-of-acinetobacter-baumannii
#2
Woon Young Song, Dawa Jeong, Jimin Kim, Min Wook Lee, Man Hwan Oh, Hak Joong Kim
Acinetobactin is a major siderophore utilized by the human pathogen Acinetobacter baumannii. The rapid acquisition of drug resistance by A. baumannii has garnered concern globally. Herein, acinetobactin and systematically generated analogues were prepared and characterized; the binding and cellular delivery of Fe(III) by the analogues were evaluated. This investigation not only led to the clarification of the physiologically relevant acinetobactin structure but also revealed several key structural elements for its functionality as a siderophore...
January 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28101785/acinetobacter-baumannii-bacteraemia-in-patients-with-haematological-malignancy-a-multicentre-retrospective-study-from-the-infection-working-party-of-jiangsu-society-of-hematology
#3
X Wang, L Zhang, A Sun, X Yang, W Sang, Y Jiang, J Cheng, J Wang, M Zhou, B Chen, J Ouyang
Acinetobacter baumannii (Ab) bacteraemia in patients with haematological malignancies is fatal but rarely reported. We explored the clinical characteristics, drug resistances and prognostic factors in these patients. This multicentre, retrospective study was conducted at the department of haematology wards of 18 tertiary hospitals in China from January 2014 to June 2015. The total clinical isolates from every source were collected from patients with haematological malignancy. Haematological malignancy patients diagnosed with Ab bacteraemia were analysed...
January 18, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28101158/prevalence-of-carbapenemases-among-high-level-aminoglycoside-resistant-acinetobacter-baumannii-isolates-in-a-university-hospital-in-china
#4
Yanhong Wang, Min Shen, Jingni Yang, Min Dai, Yaowen Chang, Chi Zhang, Guangxin Luan, Baodong Ling, Xu Jia
The prevalence of aminoglycoside resistant enzymes has previously been reported and extended-spectrum β-lactamase among Acinetobacter baumannii. To track the risk of multidrug-resistant A. baumannii, the present study aimed to determine the prevalence of carbapenemases in high-level aminoglycoside resistant A. baumannii over two years. A total of 118 strains of A. baumannii were consecutively collected in the First Affiliated Hospital of Chengdu Medical College, Chengdu, China. These isolates were investigated on the genetic basis of their resistance to aminoglycosides...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100307/the-kl24-gene-cluster-and-a-genomic-island-encoding-a-wzy-polymerase-contribute-genes-needed-for-synthesis-of-the-k24-capsular-polysaccharide-by-the-multiply-antibiotic-resistant-acinetobacter-baumannii-isolate-rch51
#5
Johanna J Kenyon, Anastasiya A Kasimova, Mikhail Shneider, Alexander S Shashkov, Nikolay P Arbatsky, Anastasiya V Popova, Konstantin A Miroshnikov, Ruth M Hall, Yuriy A Knirel
The whole genome sequence of the multiply antibiotic resistant Acinetobacter baumannii isolate RCH51 belonging to sequence type ST103 (Institut Pasteur scheme) revealed that the set of genes at the capsule locus, KL24, includes four genes predicted to direct the synthesis of 3-acetamido-3,6-dideoxy-D-galactose (D-Fuc3NAc) and this sugar was found in the capsular polysaccharide (CPS). One of these genes, fdtE, encodes a novel bifunctional protein with an N-terminal FdtA 3,4-ketoisomerase domain and a C-terminal acetyltransferase domain...
January 17, 2017: Microbiology
https://www.readbyqxmd.com/read/28100110/mortality-in-patients-with-septic-shock-by-multidrug-resistant-bacteria
#6
Stefano Busani, Giulia Serafini, Elena Mantovani, Claudia Venturelli, Maddalena Giannella, Pierluigi Viale, Cristina Mussini, Andrea Cossarizza, Massimo Girardis
BACKGROUND: Patients with septic shock by multidrug resistant (MDR) microorganism maybe considered a specific population of critical patients at very high risk of death in whom the effects of standard sepsis treatment has never been assessed. The objective of this retrospective analysis was to evaluate the risk factors for 30-day mortality and the impact of sepsis management in patients with septic shock caused by MDR bacteria. METHODS: Patients with septic shock by MDR bacteria admitted to the mixed intensive care unit (ICU) of Modena University Hospital during a 6-year period were studied...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28099994/the-impact-of-primer-sets-on-detection-of-the-gene-encoding-biofilm-associated-protein-bap-in-acinetobacter-baumannii-in-silico-and-in-vitro-analysis
#7
Mansoor Kodori, Masoumeh Douraghi, Mehdi Yaseri, Mohammad Rahbar
The Acinetobacter baumannii virulence protein Bap is encoded by a large gene and contains both variable sequence and repetitive modules. To date, four primer sets targeting different regions of bap have been designed, but no study has evaluated all these primers simultaneously for detection of bap. Here, we assessed the effect of primer sets Bap I to IV, on detection of bap both in silico and in vitro. Using the primer set Bap II, all 143 tested strains yielded an amplicon corresponding to bap gene. This primer set showed the highest sensitivity (100%, 95% CI: 97...
January 18, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28099062/rectal-carriage-of-extended-spectrum-beta-lactamase-and-carbapenemase-producing-gram-negative-bacilli-in-intensive-care-units-in-tunisia
#8
Samia Hammami, Chaima Dahdeh, Kelthoum Mamlouk, Sana Ferjeni, Elaa Maamar, Zeineb Hamzaoui, Mabrouka Saidani, Salma Ghedira, Mohamed Houissa, Amin Slim, Ilhem Boutiba-Ben Boubaker
This study was conducted to evaluate the rate of fecal carriage of Gram-negative bacilli (GNB) resistant to third-generation cephalosporins (third GC) in patients hospitalized in the intensive care unit (ICU) of Charles Nicolle Hospital of Tunis and to identify the enzymatic mechanisms involved. From February to April 2014, rectal swabs were collected from all patients (n = 38) at admission and once weekly thereafter to identify acquisition. They were cultured on desoxycholate-lactose-agar plates supplemented with cefotaxime (2 mg/L)...
January 18, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28089718/cathelicidin-antimicrobial-peptide-from-alligator-mississippiensis-has-antibacterial-activity-against-multi-drug-resistant-acinetobacter-baumanii-and-klebsiella-pneumoniae
#9
Stephanie M Barksdale, Evelyn J Hrifko, Monique L van Hoek
Alligator mississippiensis (American alligator), a member of order Crocodilia, lives in bacteria-laden environments but is not often known to succumb to bacterial infections. Their serum has been shown to have antibacterial activity beyond that of human serum, and it is believed that this activity is partially due to cationic antimicrobial peptides (CAMPs). CAMPs are produced by many organisms as part of the innate immune system. CAMPs are attractive possible therapies against multi-drug resistant bacteria, such as those found in biofilm-infected war wounds, because they seldom cause genetic resistance in bacteria and are effective against antibiotic resistant bacteria...
January 12, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28089178/hatchery-workers-igg-antibody-profiles-to-airborne-bacteria
#10
Paul Brauner, Silvana Gromöller, Yvonne Pfeifer, Gottfried Wilharm, Udo Jäckel
Occupational exposure to high concentrations of airborne bacteria in poultry production is related to an increased risk of respiratory disorders. However, etiology and in particular microorganisms' potential role in pathogenesis still needs to be elucidated. Thus, detection of specific antibodies against occupational microbial antigens may lead to identification of potentially harmful species. For the purpose of IgG titer determination, indirect immunofluorescence on various bacterial isolates from duck hatchery air was combined with image-based quantification of fluorescence intensity...
December 26, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28088916/an-increasing-threat-in-an-iranian-referral-children-s-hospital-multidrug-resistant-acinetobacter-baumannii
#11
Setareh Mamishi, Reza Habibi, Babak Pourakbari, Shima Mahmoudi, Mohammad Taghi Haghi Ashtiani, Reihaneh Hosseinpour Sadeghi, Mahmoud Khodabandeh
INTRODUCTION: Acinetobacter baumannii has emerged as an important nosocomial pathogen in the past decades. Due to the prevalence of A. baumannii across the world, suitable typing methods to investigate the epidemiological distribution of the organism have been developed. The aim of this study was to investigate the epidemiological and molecular diversity of A. baumannii strains isolated from nosocomial infections of hospitalized children in Children Medical Center Hospital (CMC), an Iranian referral hospital, in Tehran, Iran...
January 13, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28088439/antimicrobial-activity-of-photodynamic-therapy-in-combination-with-colistin-against-a-pan-drug-resistant-acinetobacter-baumannii-isolated-from-burn-patient
#12
Ebrahim Boluki, Hossein Kazemian, Hadi Peeridogaheh, Mohammad Yousef Alikhani, Sima Shahabi, Leili Beytollahi, Roghayeh Ghorbanzadeh
Nosocomially-acquired multi-, extensively-, and pandrug resistant (MDR, XDR, and PDR) strains of microorganisms such as Acinetobacter baumannii remain a serious cause of infection and septic mortality in burn patients. Treatment of patients with nosocomial burn wound infections is often complicated by drug-resistant strains of A. baumannii. Today, many researchers are focusing on the investigation of novel non-antibiotic strategies such as photodynamic therapy (PDT). We report a new PDT strategy that suppresses colistin resistance in PDR A...
January 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28081345/growing-oxa-23-type-strains-among-carbapenem-resistant-acinetobacter-baumannii-and-tigecycline-as-an-alternate-combination-therapy
#13
Şerife Altun, Zeliha Koçak Tufan, Belgin Altun, Ufuk Önde, Sami Kınıklı, Ali Pekcan Demiröz
BACKGROUND/AIM: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains. MATERIALS AND METHODS: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28080212/heterogeneity-of-carbapenem-resistance-mechanisms-among-gram-negative-pathogens-in-lebanon-results-of-the-first-cross-sectional-countrywide-study
#14
Dalal Hammoudi Halat, Carole Ayoub Moubareck, Dolla Karam Sarkis
Carbapenem-resistant Gram-negative pathogens have progressively disseminated to different countries worldwide, presenting a serious public health concern. The aims of this study were to determine the prevalence of carbapenem resistance in Gram-negative bacteria in Lebanon, to elucidate molecular mechanisms, and to identify genetic relatedness of incriminated strains. Carbapenem nonsusceptible Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas were collected from 11 Lebanese hospitals in 2012. Antimicrobial susceptibility was assessed with phenotypic tests, genes encoding carbapenemases were screened via PCR-sequencing, and genetic relatedness was examined by PGFE and ERIC-PCR...
January 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28073968/variants-of-abgri3-carrying-the-arma-gene-in-extensively-antibiotic-resistant-acinetobacter-baumannii-from-singapore
#15
Grace A Blackwell, Kathryn E Holt, Stephen D Bentley, Li Yang Hsu, Ruth M Hall
OBJECTIVES: To investigate the context of the ribosomal RNA methyltransferase gene armA in carbapenem-resistant global clone 2 (GC2) Acinetobacter baumannii isolates from Singapore. METHODS: Antibiotic resistance was determined using disc diffusion; PCR was used to identify resistance genes. Whole genome sequences were determined and contigs were assembled and ordered using PCR. Resistance regions in unsequenced isolates were mapped. RESULTS: Fifteen GC2 A...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28073895/evaluation-of-genotypic-and-phenotypic-methods-to-detect-carbapenemase-production-in-gram-negative-bacilli
#16
Allison R McMullen, Melanie L Yarbrough, Meghan A Wallace, Angela Shupe, Carey-Ann D Burnham
BACKGROUND: Carbapenemase-producing gram-negative bacteria (CP-GNB) are an urgent and expanding public health threat. Rapid and accurate identification of these organisms facilitates infection prevention efforts in healthcare facilities. The objective of our study was to evaluate methods to detect and identify CP-GNB. METHODS: We examined 189 carbapenem-resistant GNB (CR-GNB), including Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii complex, using 3 different methods: 2 methods to screen isolates of GNB for carbapenemase production [the carbapenem inactivation method (CIM) and 2 chromogenic agars] and a molecular method (Cepheid GeneXpert Carba-R) to identify the mechanism of carbapenem resistance and the associated resistance genes (blaKPC, blaNDM, blaIMP, blaOXA-48-like, and blaVIM)...
January 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28070537/molecular-analysis-and-expression-of-bap-gene-in-biofilm-forming-multi-drug-resistant-acinetobacter-baumannii
#17
Azizi Omid, Shahcheraghi Fereshteh, Salimizand Himen, Modarresi Farzan, Shakibaie Mohammad Reza, Mansouri Shahla, Ramazanzadeh Rashid, Badmasti Farzad, Nikbin Vajihe
BACKGROUND: Acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. In this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap) in development of biofilm among multi-drug-resistant A. baumannii (MDRAB). METHODS: Sixty-five MDRAB isolates from clinical samples were collected...
October 2016: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28069648/the-acinetobacter-outer-membrane-contains-multiple-specific-channels-for-carbapenem-%C3%AE-lactams-as-revealed-by-kinetic-characterization-analyses-of-imipenem-permeation-into-acinetobacter-baylyi-cells
#18
Jorgelina Morán-Barrio, María M Cameranesi, Verónica Relling, Adriana S Limansky, Luciano Brambilla, Alejandro M Viale
The number and type of outer membrane (OM) channels responsible of carbapenem uptake in Acinetobacter are still not well defined. Here, we addressed these questions using Acinetobacter baylyi as a model species and a combination of methodologies aimed to characterize OM channels in their original membrane environment. Kinetic and competition analyses of imipenem (IPM) uptake by A. baylyi whole cells allowed us to identify different carbapenem-specific OM uptake sites. Comparative analyses of IPM uptake by A...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28065568/synthesis-and-antimicrobial-studies-of-novel-derivatives-of-4-4-formyl-3-phenyl-1h-pyrazol-1-yl-benzoic-acid-as-potent-anti-acinetobacter-baumannii-agents
#19
Devin Allison, Evan Delancey, Hunter Ramey, Conrad Williams, Zakeyah Ali Alsharif, Hessa Al-Khattabi, Allyn Ontko, David Gilmore, Mohammad A Alam
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the world is moving toward a post-antibiotic era, in which normal infections or minor injuries may become fatal. In an effort to find new agents, we report the synthesis and antimicrobial activities of 40 novel 1,3-diphenyl pyrazole derivatives. These compounds have shown zones of growth inhibition up to 85mm against Acinetobacter baumannii...
December 29, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28064057/udp-n-acetylglucosamine-enolpyruvyl-transferase-mura-of-acinetobacter-baumannii-abmura-structural-and-functional-properties
#20
Amit Sonkar, Harish Shukla, Rohit Shukla, Jupitara Kalita, Tripti Pandey, Timir Tripathi
Peptidoglycan (PG) is the key component of the bacterial cell wall. The enzyme UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) catalyzes the transfer of enolpyruvate from phosphoenolpyruvate (PEP) to uridinediphospho-N-acetylglucosamine (UNAG), which is the first committed step of PG biosynthesis. Here, we present the biochemical and structural features of the MurA enzyme of the opportunistic pathogen Acinetobacter baumannii (AbMurA). The recombinant AbMurA exists as a monomer in solution and shows optimal activity at pH 7...
January 4, 2017: International Journal of Biological Macromolecules
keyword
keyword
3759
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"