keyword
https://read.qxmd.com/read/38537125/efficacy-of-a-novel-antibiotic-drug-combination-toward-multidrug-resistant-ocular-pathogens
#1
JOURNAL ARTICLE
Lakshminarayanan Gowtham, Rachel A F Wozniak, Paul M Dunman, Esther Sheba, Prashant Garg, Joveeta Joseph
PURPOSE: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment of multidrug-resistant (MDR) bacterial infections. In this study, we sought to evaluate the in vitro efficacy of a novel drug combination, polymyxin B/trimethoprim (PT) + rifampin on MDR isolates from patients with bacterial keratitis in India. METHODS: Forty-three isolates, which included 20 Staphylococcus aureus, 19 Pseudomonas aeruginosa, 3 Pseudomonas stutzeri, and 1 Acinetobacter baumannii, were evaluated for their antibiotic resistance by minimum inhibitory concentration (MIC)...
March 26, 2024: Cornea
https://read.qxmd.com/read/38536111/efflux-pump-inhibitor-potentiates-the-antimicrobial-photodynamic-inactivation-of-multidrug-resistant-acinetobacter-baumannii
#2
JOURNAL ARTICLE
Zahra Shirdel, Zahra Fekrirad
Background: Acinetobacter baumannii , a nosocomial pathogen, poses a major public health problem due to generating resistance to several antimicrobial agents. Antimicrobial photodynamic inactivation (APDI) employs a nontoxic dye as a photosensitizer (PS) and light to produce reactive oxygen species that destroy bacterial cells. The intracellular concentration of PS could be affected by factors such as the function of efflux pumps to emit PS from the cytosol. Objective: To evaluate the augmentation effect of an efflux pump inhibitor, verapamil, three multidrug-resistant A...
March 27, 2024: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/38535540/types-and-mechanisms-of-efflux-pump-systems-and-the-potential-of-efflux-pump-inhibitors-in-the-restoration-of-antimicrobial-susceptibility-with-a-special-reference-to-acinetobacter-baumannii
#3
REVIEW
Kira M Zack, Trent Sorenson, Suresh G Joshi
Bacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells. Thus, efflux pump systems participate in lowering intracellular concentrations of antibiotics, which allows phenotypic multidrug-resistant (MDR) bacteria to survive effectively amid higher concentrations of antibiotics. Acinetobacter baumannii is one of the classic examples of pathogens that can carry multiple efflux pump systems, which allows these bacteria to be MDR-to-pan-drug resistant and is now considered a public health threat...
February 23, 2024: Pathogens
https://read.qxmd.com/read/38534721/high-loading-dose-colistin-with-nebulized-administration-for-carbapenem-resistant-acinetobacter-baumannii-pneumonia-in-critically-ill-patients-a-retrospective-cohort-study
#4
JOURNAL ARTICLE
Wasan Katip, Ajaree Rayanakorn, Chuleegone Sornsuvit, Purida Wientong, Peninnah Oberdorfer, Puntapong Taruangsri, Teerapong Nampuan
Carbapenem-resistant Acinetobacter baumannii (CRAB) infections pose a serious threat, with high morbidity and mortality rates. This retrospective cohort study, conducted at Nakornping Hospital between January 2015 and October 2022, aimed to evaluate the efficacy and safety of a high loading dose (LD) of colistin combined with nebulized colistin in critically ill patients with CRAB pneumonia. Of the 261 patients included, 95 received LD colistin, and 166 received LD colistin with nebulized colistin. Multivariate Cox regression analysis, adjusted for baseline covariates using inverse probability weighting, showed no significant difference in 30-day survival between patients who received LD colistin and those who received LD colistin with nebulized colistin (adjusted hazard ratio [aHR]: 1...
March 21, 2024: Antibiotics
https://read.qxmd.com/read/38534701/identification-and-clinical-characteristics-of-community-acquired-acinetobacter-baumannii-in-patients-hospitalized-for-moderate-or-severe-covid-19-in-peru
#5
JOURNAL ARTICLE
Wilmer Silva-Caso, Giancarlo Pérez-Lazo, Miguel Angel Aguilar-Luis, Adriana Morales-Moreno, José Ballena-López, Fernando Soto-Febres, Johanna Martins-Luna, Luis J Del Valle, Sungmin Kym, Deysi Aguilar-Luis, Dayana Denegri-Hinostroza, Juana Del Valle-Mendoza
Acinetobacter baumannii has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534696/current-therapeutic-approaches-for-multidrug-resistant-and-extensively-drug-resistant-acinetobacter-baumannii-infections
#6
REVIEW
Petros Rafailidis, Periklis Panagopoulos, Christos Koutserimpas, George Samonis
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A. baumannii infections on morbidity and mortality, as well on financial resources, remain dire. Furthermore, A. baumannii superinfections have also occurred during the COVID-19 pandemic. While prevention is important, the antibiotic armamentarium remains the most essential factor for the treatment of these infections...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534693/intrapulmonary-and-systemic-pharmacokinetics-of-colistin-following-nebulization-of-low-dose-colistimethate-sodium-in-patients-with-ventilator-associated-pneumonia-caused-by-carbapenem-resistant-acinetobacter-baumannii
#7
JOURNAL ARTICLE
Dong-Hwan Lee, Shin-Young Kim, Yong-Kyun Kim, So-Young Jung, Ji-Hoon Jang, Hang-Jea Jang, Jae-Ha Lee
Colistimethate sodium (CMS) nebulization is associated with reduced systemic toxicity compared to intravenous injection, with potentially enhanced clinical efficacy. This study aimed to assess the pharmacokinetic (PK) properties of colistin during low-dose CMS nebulization in patients with ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii . A nonlinear mixed-effects modeling approach was applied to develop population PK models for colistin in both epithelial lining fluid (ELF) and plasma...
March 14, 2024: Antibiotics
https://read.qxmd.com/read/38534692/pan-genome-plasticity-and-virulence-factors-a-natural-treasure-trove-for-acinetobacter-baumannii
#8
REVIEW
Theodoros Karampatakis, Katerina Tsergouli, Payam Behzadi
Acinetobacter baumannii is a Gram-negative pathogen responsible for a variety of community- and hospital-acquired infections. It is recognized as a life-threatening pathogen among hospitalized individuals and, in particular, immunocompromised patients in many countries. A. baumannii, as a member of the ESKAPE group, encompasses high genomic plasticity and simultaneously is predisposed to receive and exchange the mobile genetic elements (MGEs) through horizontal genetic transfer (HGT). Indeed, A. baumannii is a treasure trove that contains a high number of virulence factors...
March 14, 2024: Antibiotics
https://read.qxmd.com/read/38534648/risk-factors-associated-with-mortality-in-acinetobacter-baumannii-infections-results-of-a-prospective-cohort-study-in-a-tertiary-public-hospital-in-guayaquil-ecuador
#9
JOURNAL ARTICLE
Luz Abarca-Coloma, Miguel Puga-Tejada, Tamara Nuñez-Quezada, Otilia Gómez-Cruz, Carlos Mawyin-Muñoz, Shivan Barungi, Macarena Perán
Antibiotic overuse and the resulting antimicrobial resistance pose significant global public health challenges, providing an avenue for opportunistic pathogens like Acinetobacter baumannii to thrive. This study will report the trends of Acinetobacter baumannii antimicrobial resistance patterns at the Hospital Teodoro Maldonado Carbo, Ecuador. An observational, analytical, longitudinal, and prospective study was conducted involving patients diagnosed with hospital-acquired infections. Antimicrobial susceptibility testing was performed, followed by molecular analysis of carbapenemase genes in Acinetobacter baumannii isolates...
February 23, 2024: Antibiotics
https://read.qxmd.com/read/38534644/a-ftsz-inhibitor-that-can-utilize-siderophore-ferric-iron-uptake-transporter-systems-for-activity-against-gram-negative-bacterial-pathogens
#10
JOURNAL ARTICLE
Eric J Bryan, Qi Qiao, Yuxuan Wang, Jacques Y Roberge, Edmond J LaVoie, Daniel S Pilch
The global threat of multidrug-resistant Gram-negative bacterial pathogens necessitates the development of new and effective antibiotics. FtsZ is an essential and highly conserved cytoskeletal protein that is an appealing antibacterial target for new antimicrobial therapeutics. However, the effectiveness of FtsZ inhibitors against Gram-negative species has been limited due in part to poor intracellular accumulation. To address this limitation, we have designed a FtsZ inhibitor ( RUP4 ) that incorporates a chlorocatechol siderophore functionality that can chelate ferric iron (Fe3+ ) and utilizes endogenous siderophore uptake pathways to facilitate entry into Gram-negative pathogens...
February 22, 2024: Antibiotics
https://read.qxmd.com/read/38532154/antibacterial-activity-of-plants-in-cirsium-a-comprehensive-review
#11
REVIEW
Xiao-Meng Tang, Ming-Xia Xie, Jun-Li Gou, Liang Chen, Jin-Long Tian, Xia Zhang, You-Yuan Lu, Han-Qing Wang
As ethnic medicine, the whole grass of plants in Cirsium was used as antimicrobial. This review focuses on the antimicrobial activity of plants in Cirsium, including antimicrobial components, against different types of microbes and bacteriostatic mechanism. The results showed that the main antimicrobial activity components in Cirsium plants were flavonoids, triterpenoids and phenolic acids, and the antimicrobial ability varied according to the species and the content of chemicals. Among them, phenolic acids showed a strong antibacterial ability against Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus faecium...
March 27, 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38531847/antimicrobial-resistance-burden-pre-and-post-covid-19-pandemic-with-mapping-the-multidrug-resistance-in-egypt-a-comparative-cross-sectional-study
#12
JOURNAL ARTICLE
Shaimaa Abdelaziz Abdelmoneim, Ramy Mohamed Ghazy, Eman Anwar Sultan, Mahmoud A Hassaan, Mohamed Anwar Mahgoub
Overuse of antibiotics during coronavirus disease 2019 (COVID-19) in an attempt to reduce COVID-19 mortality in the short term may have contributed to long-term mortality from antimicrobial resistance (AMR). The aim of this study was to evaluate the impact of the COVID-19 pandemic on AMR in Egypt and map the distribution of multidrug-resistant (MDR) and extensive drug-resistant (XDR) across Egypt. Through a multicenter cross-sectional study 2430 culture results were collected in 2019 and 2022 pre and post-COVID-19 pandemic in Egypt, including 400 Klebsiella pneumoniae, 760 Escherichia coli, 650 Acinetobacter baumannii, and 620 Methicillin-resistant staphylococcus aureus (MRSA) culture results...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531599/esktides-a-comprehensive-database-and-mining-method-for-eskape-phage-derived-antimicrobial-peptides
#13
JOURNAL ARTICLE
Hongfang Wu, Rongxian Chen, Xuejian Li, Yue Zhang, Jianwei Zhang, Yanbo Yang, Jun Wan, Yang Zhou, Huanchun Chen, Jinquan Li, Runze Li, Geng Zou
'Superbugs' have received increasing attention from researchers, such as ESKAPE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.), which directly led to about 1 270 000 death cases in 2019. Recently, phage peptidoglycan hydrolases (PGHs)-derived antimicrobial peptides were proposed as new antibacterial agents against multidrug-resistant bacteria. However, there is still a lack of methods for mining antimicrobial peptides based on phages or phage PGHs...
March 26, 2024: Database: the Journal of Biological Databases and Curation
https://read.qxmd.com/read/38530969/characterization-of-the-diversity-of-type-iv-secretion-system-encoding-plasmids-in-acinetobacter
#14
JOURNAL ARTICLE
Farah Nasser, Avery Gaudreau, Shareefah Lubega, Arvin Zaker, Xuhua Xia, Arvind S Mer, Vanessa M D'Costa
The multi-drug resistant pathogen Acinetobacter baumannii has gained global attention as an important clinical challenge. Owing to its ability to survive on surfaces, its capacity for horizontal gene transfer, and its resistance to front-line antibiotics, A. baumannii has established itself as a successful pathogen. Bacterial conjugation is a central mechanism for pathogen evolution. The epidemic multidrug-resistant A. baumannii ACICU harbours a plasmid encoding a Type IV Secretion System (T4SS) with homology to the E...
December 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38530861/aminoglycoside-resistance-genes-in-early-members-of-the-acinetobacter-baumannii-st78a-smal-italian-clone-reside-in-an-is26-bounded-island-in-the-chromosome
#15
JOURNAL ARTICLE
Christopher J Harmer, Sarah M Cahill, Johanna J Kenyon, Ruth M Hall
BACKGROUND: The Acinetobacter baumannii isolate called SMAL, previously used to determine the structures of capsular polysaccharide and lipooligosaccharide, was recovered in Pavia, Italy in 2002 among the collection of aminoglycoside-resistant isolates designated as SMAL type. This type was later called the Italian clone, then ST78. ST78 isolates are now widely distributed. OBJECTIVES: To establish the resistance gene complement and the location and structure of acquired resistance regions in early members of the Italian/ST78 clone...
March 26, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38530465/multidrug-resistant-organism-bloodstream-infection-and-hospital-acquisition-among-inpatients-in-three-tertiary-greek-hospitals-during-the-covid-19-era
#16
JOURNAL ARTICLE
Polyxeni Karakosta, Sophia Vourli, Elisavet Kousouli, Georgios Meletis, Areti Tychala, Christina Louka, Alexandra Vasilakopoulou, Efthymia Protonotariou, Vasiliki Mamali, Olympia Zarkotou, Lemonia Skoura, Spyros Pournaras
From 2019 (pre-COVID-19) to 2022 (COVID-19 years), three tertiary Greek hospitals monitored MDRO bloodstream infection (BSI) and hospital acquisition relying on laboratory data. Surveillance covered carbapenem-resistant Enterobacterales (CRE), Acinetobacter baumannii (CRAB), Pseudomonas aeruginosa (CRPA), vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA), in intensive care units (ICUs) and non-ICUs. Non-ICUs experienced significant increases in CRE, CRAB and VRE during the pandemic...
March 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38527906/europium-ion-based-magnetic-trapping-and-fluorescence-sensing-method-for-detection-of-pathogenic-bacteria
#17
JOURNAL ARTICLE
Miftakhul Jannatin, Tzu-Ling Yang, Yi-Yuan Su, Ru-Tsun Mai, Yu-Chie Chen
Europium ions (Eu3+ ) have been utilized as a fluorescence-sensing probe for a variety of analytes, including tetracycline (TC). When Eu3+ is chelated with TC, its fluorescence can be greatly enhanced. Moreover, Eu3+ possesses 6 unpaired electrons in its f orbital, which makes it paramagnetic. Being a hard acid, Eu3+ can chelate with hard bases, such as oxygen-containing functional groups (e.g., phosphates and carboxylates), present on the cell surface of pathogenic bacteria. Due to these properties, in this study, Eu3+ was explored as a magnetic-trapping and sensing probe against pathogenic bacteria present in complex samples...
March 25, 2024: Analytical Chemistry
https://read.qxmd.com/read/38525636/an-outbreak-within-an-outbreak-the-impact-of-infection-prevention-and-control-strategies-on-hospital-acquired-infections-and-the-occurrence-of-multi-drug-resistant-organisms-during-the-covid-19-pandemic
#18
JOURNAL ARTICLE
B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic placed an unprecedented strain on intensive care units (ICUs) in South Africa. Infection prevention and control (IPC) strategies were highlighted to minimise the risk to healthcare workers and for the protection of patients from contracting hospital-acquired infections (HAIs). During the third wave, our institution adopted a shift system to address severe burnout among ICU personnel. We noted an upstroke in the occurrence of HAIs, specifically carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant (MDR) Acinetobacter baumannii...
December 4, 2023: South African Medical Journal
https://read.qxmd.com/read/38524834/hemorrhagic-bronchitis-caused-by-carbapenem-resistant-acinetobacter-baumannii-infection-a-case-report
#19
Zifang Li, Yu Sheng, Dongdong Huang
Carbapenem-resistant Acinetobacter baumannii (CR-AB) is rarely found in community respiratory infections, and there are currently no reports of hemorrhagic bronchitis caused by its infection. This work presents a case of bronchial bleeding in a diabetic patient who acquired a community-acquired infection of CR-AB. Treatment with levofloxacin was unsuccessful, as the patient's hemoptysis symptoms recur. The patient was treated with minocycline based on the drug sensitivity test, resulting in the disappearance of hemoptysis symptoms...
2024: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38524570/genotypic-and-phenotypic-mechanisms-underlying-antimicrobial-resistance-and-synergistic-efficacy-of-rifampicin-based-combinations-against-carbapenem-resistant-acinetobacter-baumannii
#20
JOURNAL ARTICLE
Lois Chinwe Nwabor, Arnon Chukamnerd, Ozioma Forstinus Nwabor, Komwit Surachat, Rattanaruji Pomwised, Kongpop Jeenkeawpiam, Sarunyou Chusri
PURPOSE: Carbapenem-resistant Acinetobacter baumannii (CRAB) is an urgent concern to public health. This study focuses on exploring the resistance mechanisms and the in vitro results of using rifampicin in combination with conventional antibiotics for the management of CRAB. METHODS: The synergistic and bactericidal effects of rifampicin with conventional antibiotics were evaluated using chequerboard assay and time-kill assay, while the phenotypic and genotypic characteristics of resistant determinants were performed by efflux pump detection and whole genome sequencing on 29 isolates from ICU patients with underlying health diseases...
March 30, 2024: Heliyon
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