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https://www.readbyqxmd.com/read/27936467/clinical-relevance-of-cell-free-dna-in-gastrointestinal-tract-malignancy
#1
Yuan-Tzu Lan, Ming-Huang Chen, Wen-Liang Fang, Chih-Cheng Hsieh, Chien-Hsing Lin, Fang-Yu Jhang, Shung-Haur Yang, Jen-Kou Lin, Wei-Shone Chen, Jeng-Kai Jiang, Pei-Ching Lin, Shih-Ching Chang
BACKGROUND: Cell-free DNA (cfDNA) extracted from blood has become a clinically feasible biomarker in various types of cancer. However, the clinical significance of cfDNA in gastrointestinal (GI) tract cancer among Asian populations requires further investigation. RESULTS: The median cfDNA copy number was highest in esophageal cancer, followed by colorectal cancer and gastric cancer, which were all significantly higher than those of healthy individuals. The cfDNA levels were higher in GI tract cancer, followed by those in carcinoma in situ and then healthy individuals (P = 0...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27932438/squamous-cell-carcinoma-of-the-extrahepatic-bile-duct-with-metachronous-para-aortic-lymph-node-metastasis-successfully-treated-with-s-1-plus-cisplatin
#2
Ryohei Nishiguchi, Dal Ho Kim, Masayuki Honda, Tsuguo Sakamoto
The most common histological classification of bile duct cancer is adenocarcinoma and squamous cell carcinoma (SCC) is relatively rare. We report a case of a 78-year-old man with SCC of the extrahepatic bile duct associated with metachronous para-aortic lymph node metastasis. He had undergone subtotal stomach-preserving pancreatoduodenectomy. The pathological findings demonstrated moderately differentiated SCC of the distal extrahepatic bile duct (T1N1M0, stage IIB). 6 months after surgery, recurrence of the para-aortic lymph node was shown in abdominal CT...
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27923621/transcriptomic-analysis-of-gene-expression-profiles-of-stomach-carcinoma-reveal-abnormal-expression-of-mitotic-components
#3
Hongfei Tong, Jisheng Wang, Hui Chen, Zhaohong Wang, Henwei Fan, Zhonglin Ni
AIMS: In order to explore the etiology of gastric cancer on global gene expression level, we developed advanced bioinformatic analysis to investigate the variations of global gene expression and the interactions among them. MAIN METHODS: We downloaded the dataset GSE63288 from Gene Expression Omnibus (GEO) database which included 22 human gastric cancer and 22 healthy control samples. We identified the differential expression genes, and explored the Gene ontology (GO) and pathways of the differentially expressed genes...
December 3, 2016: Life Sciences
https://www.readbyqxmd.com/read/27920769/transcriptional-profiling-of-type-ii-toxin-antitoxin-genes-of-helicobacter-pylori-under-different-environmental-conditions-identification-of-hp0967-hp0968-system
#4
María G Cárdenas-Mondragón, Miguel A Ares, Leonardo G Panunzi, Sabino Pacheco, Margarita Camorlinga-Ponce, Jorge A Girón, Javier Torres, Miguel A De la Cruz
Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa and is responsible for causing peptic ulcers and gastric carcinoma. The expression of virulence factors allows the persistence of H. pylori in the stomach, which results in a chronic, sometimes uncontrolled inflammatory response. Type II toxin-antitoxin (TA) systems have emerged as important virulence factors in many pathogenic bacteria. Three type II TA systems have previously been identified in the genome of H. pylori 26695: HP0315-HP0316, HP0892-HP0893, and HP0894-HP0895...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27916775/a-case-report-of-adenosquamous-cell-carcinoma-of-the-duodenal-papilla
#5
Yuki Segi, Akira Hashimoto, Hiroki Yukimoto, Naohiko Yoshizawa, Masatoshi Aoki, Hiroyuki Fuke, Hiroyuki Kawabata, Atsuya Shimizu, Ken Ichikawa, Hiroshi Nakano
Adenosquamous carcinoma of the duodenal papilla is rare. A 73-year-old man was referred to the Saiseikai-Matsusaka General Hospital with upper abdominal pain and liver dysfunction. Computed tomography (CT) revealed dilatation of the common bile duct (CBD) and intrahepatic bile duct along with a tumor in the distal CBD. The tumor showed enhancement in the arterial phase on contrast-enhanced CT. We performed endoscopic retrograde cholangiopancreatography and noted a red, erosive, bleeding mass in the duodenal papilla with obstruction of the distal CBD, and dilatation of the CBD...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27894812/enhanced-legumain-recognition-and-nir-controlled-released-of-cisplatin-indocyanine-nanosphere-against-gastric-carcinoma
#6
Tianyi Shi, Lianshuai Gu, Yu Sun, Senlin Wang, Chaoqun You, Xiangyang Zhang, Jin Zhu, Baiwang Sun
Cisplatin-therapy has faced limitations in the gastric cancer therapy. To settle the bottleneck, enhanced specificity and controlled-release property are choosen. We synthesize cisplatin and indocyanine green (ICG) loaded PLGA-(DSPE-PEG2000) nanoparticles, which is abbreviated as CINPs. And we conjugate the Gly-Cys-Gly-Ala-Ala-Asn-Leu (GCGAANL) heptapeptide upon the surface of CINPs, the product is abbreviated as ACINPs. ACINPs with nearly 110nm exhibit good monodispersity and size stability. The EE (efficiency of encapsulation) and LE (loading of encapsulation) of cisplatin loaded into ACINPs are optimized as 29...
November 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27894759/pancreaticoduodenectomy-for-pediatric-and-adolescent-pancreatic-malignancy-a-single-center-retrospective-analysis
#7
Erika B Lindholm, Abdulaziz K Alkattan, Sara J Abramson, Anita P Price, Todd E Heaton, Vinod P Balachandran, Michael P La Quaglia
PURPOSE: While pancreaticoduodenectomy (PD) has been extensively studied in adults, there are few data pertaining specifically to pediatric patients. We retrospectively analyzed PD-associated morbidity and mortality in pediatric patients. METHODS: Our analytic cohort included all consecutive patients ≤18years of age treated at our institution from 1993 to 2015 who underwent PD. Patient data (demographics, disease characteristics, surgical and adjuvant treatment, length of hospital stay, and postoperative course) were extracted from the medical records...
November 16, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27886029/prevalence-of-h-pylori-in-gastric-biopsy-specimen-in-the-southeastern-region-of-turkey
#8
Fulya Bayındır Bilman, Mehmet Özdemir, Birol Baysal, Muhammed Güzel Kurtoğlu
INTRODUCTION: Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes human gastric mucosa. Gastric ulcer, duodenal ulcer, chronic atrophic gastritis, mucosa-associated lymphoid tissue lymphoma, and stomach adenocarcinoma are associated with H. pylori as the etiological agent. Cytotoxin-associated gene A (cagA), which is one of the most important virulence factors of H. pylori, encodes a 120-145 kDa protein. The prevalence of cagA genes shows differences in H...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27879230/bilateral-cochleovestibulopathy-due-to-internal-auditory-canal-metastasis-in-a-patient-with-stomach-cancer
#9
Sertaç Yetişer
Bilateral sudden onset hearing loss and vestibular dysfunction due to metastatic carcinoma of the internal auditory canal (IAC) on both sides is an extremely rare occurrence. This is a challenging case in neuro-otology that is difficult to relieve by medical support, and spontaneous compensation by vestibular rehabilitation is minimal. The spread of tumor cells to the cerebrospinal space indicates poor prognosis. We present a patient with stage-III gastric carcinoma who experienced sudden hearing loss and severe imbalance...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27874944/rupture-of-liver-abscess-following-hepatogastric-fistula-caused-by-perforation-of-remnant-gastric-carcinoma-a-case-report
#10
L-M Qian, J-G Ge, J-M Huang
OBJECTIVE: We report the case of a 73-year-old man, with a history of proximal subtotal gastrectomy, who suffered acute abdominal symptoms and signs. Laparotomy showed rupture of liver abscess and hepatogastric fistula formation caused by perforation of remnant stomach. CASE REPORT: Residual stomach resection, incision and drainage of liver abscess were performed, and the patient was smoothly discharged from hospital nineteen days after the emergency operation. RESULTS: The final pathology confirmed the remnant gastric adenocarcinoma...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27873158/feasibility-and-importance-of-enteroscopy-after-gastric-bypass
#11
Dean Keren, H Madi, I Matter, A Assalia, T Rainis
BACKGROUND: Bariatric surgery has increased in popularity, with Roux-en-Y Gastric Bypass (RYGB) being one of the most frequently performed. This leads to many cases in which the stomach is removed from routine gastroscopy access, sometimes being a major source of concern. Performing enteroscopy in these patients is technically difficult. We present our experience with 24 cases in which the aim was to access the detached stomach. METHODS: Retrospective analysis on RYGB enteroscopy procedures aimed to access the detached stomach...
November 21, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27872140/primary-cilia-are-increased-in-number-and-demonstrate-structural-abnormalities-in-human-cancer
#12
Binnaz Yasar, Kim Linton, Christian Slater, Richard Byers
AIMS: Primary cilia play an important role in the regulation of cell signalling pathways and are thought to have a role in cancer but have seldom been studied in human cancer samples. METHODS: Primary cilia were visualised by dual immunofluorescence for anti-CROCC (ciliary rootlet coiled-coil) and anti-tubulin in a range of human cancers (including carcinomas of stomach, pancreas, prostate, lung and colon, lobular and ductal breast cancers and follicular lymphoma) and in matched normal tissue (stomach, pancreas, lung, large and small intestines, breast and reactive lymph nodes) samples using a tissue microarray; their frequency, association with proliferation, was measured by Ki-67 staining and their structure was analysed...
November 21, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27846453/a-case-report-of-chylous-ascites-after-gastric-bypass-for-morbid-obesity
#13
Esmeralda Capristo, Valerio Spuntarelli, Giorgio Treglia, Vincenzo Arena, Alessandro Giordano, Geltrude Mingrone
INTRODUCTION: We described the case of a highly aggressive antral gastric carcinoma with a scarce symptomatology, in a patient undergone Roux-en-Y Gastric Bypass (RYGB) for obesity. PRESENTATION OF CASE: A 61 year-old white man in apparent good health, who underwent laparoscopic RYGB for obesity 18 months earlier, with a loss of 30kg, reported a sudden abdominal distension and breath shortness with a weight gain of 5kg in few days. Endoscopy of both upper gastro-intestinal tract and the colon were performed along with CT-scan and positron-emission tomography (PET) CT- scan...
November 5, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27833322/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-a-rare-case-of-carcinoma-stomach-with-concomitant-silicosis
#14
Arun Sasikumar, Ajith Joy, Madhavan Unni, Jayaprakash Madhavan
The role of fluorine-18 fluorodeoxyglucose. ((18)F-FDG) positron emission tomography. (PET)/computed tomography. (CT) in the initial staging of various malignancies is now well established. However, nonspecificity of FDG occasionally results in tracer uptake in benign lung lesions. The authors describe a complicated case of carcinoma stomach with multiple nodules and a cavitary lesion in lungs where (18)F-FDG PET CT done for initial staging revealed FDG avid mass in stomach, FDG avid multiple mediastinal lymph nodes and multiple intensely FDG avid bilateral lung lesions...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27829227/targeted-therapy-of-multiple-liver-metastases-after-resected-solitary-gastric-metastasis-and-primary-pulmonary-adenocarcinoma
#15
Ling-Yu Ding, Ke-Jun Liu, Zhe-Long Jiang, Hai-Ying Wu, Shi-Xi Wu
Gastric metastases from lung adenocarcinoma are rare and usually asymptomatic. A 61-year-old woman was referred to our department because of a right lower pulmonary mass found on a chest X-ray film in August 2012. Right lower lobectomy was performed for pulmonary adenocarcinoma. Four months later, she developed epigastric discomfort. A fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) scan showed a malignancy at the cardias of the stomach. A biopsy diagnosed poorly differentiated carcinoma and a gastric carcinoma was suspected...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819872/high-throughput-protein-and-mrna-expression-based-classification-of-gastric-cancers-can-identify-clinically-distinct-subtypes-concordant-with-recent-molecular-classifications
#16
Sangjeong Ahn, So-Jeong Lee, Yonugkeum Kim, Ahrong Kim, Nari Shin, Kyung Un Choi, Chang-Hun Lee, Gi Yeong Huh, Kyong-Mee Kim, Namrata Setia, Gregory Y Lauwers, Do Youn Park
Gastric cancers have recently been classified into several types on the basis of molecular characterization, and the new taxonomy has shown to have clinical relevance. However, the technology required for thorough molecular classification is complicated and expensive, currently preventing widespread use. We aimed to reproduce the results of molecular classification using only simple techniques, that is, immunohistochemical analysis and in situ hybridization. We classified a cohort of 349 successive gastric adenocarcinomas into 5 subtypes, on the basis of protein or mRNA expression of MLH1, E-cadherin, p53, and Epstein-Barr virus...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27799228/synchronous-perforations-of-the-oesophagus-and-stomach-by-air-insufflation-an-uncommon-complication-of-endoscopic-dilation
#17
Arthur M Fung, Fion S Chan, Ian Y Wong, Simon Law
A 72-year-old woman had a history of carcinoma of the hypopharynx treated by total laryngectomy, circumferential pharyngectomy and free jejunal graft. Endoscopic dilation of the pharyngojejunal anastomotic stricture resulted in synchronous perforations of the oesophagus and stomach. We postulate that the perforations were caused by high intraoesophageal and intragastric pressure resulted from air insufflation during the procedure; in a situation simulating closed-loop obstruction, because of proximal obstruction by the endoscope at the stricture site and distal obstruction by pylorospasm...
October 31, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27796514/results-of-a-nation-wide-retrospective-study-of-lymphadenectomy-for-esophagogastric-junction-carcinoma
#18
Hiroharu Yamashita, Yasuyuki Seto, Takeshi Sano, Hiroyasu Makuuchi, Nobutoshi Ando, Mitsuru Sasako
BACKGROUND: Esophagogastric junction (EGJ) carcinoma has attracted considerable attention because of the marked increase in its incidence globally. However, the optimal extent of esophagogastric resection for this tumor entity remains highly controversial. METHODS: This was a questionnaire-based national retrospective study undertaken in an attempt to define the optimal extent of lymph node dissection for EGJ cancer. Data from patients with EGJ carcinoma, less than 40 mm in diameter, who underwent R0 resection between January 2001 and December 2010 were reviewed...
October 28, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27790307/primary-signet-ring-cell-carcinoma-of-the-prostate-treated-by-radical-cystoprostatectomy-and-chemoradiotherapy
#19
Sun Wook Kim, Woohyun Kim, Yong-Hyun Cho, Tae-Jung Kim, Insuk Woo, Dong Wan Sohn
Primary signet ring cell carcinoma (SRCC) of the prostate is very rare. Although SRCC is primarily found in the stomach and colon, it can also be found in the pancreas, breast, thyroid, bladder, and prostate. We recently diagnosed and treated a case of primary SRCC of the prostate. A 56-year-old Korean man was referred to our institution for evaluation of a one-month history of hematuria and recently identified bladder mass. Transurethral resection of the bladder tumour was performed and histological and immunohistochemical evaluation revealed a diagnosis of SRCC with tumour invading into the outer half of the deep muscularis propria...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27785936/mdct-imaging-of-the-stomach-advances-and-applications
#20
Prashant Nagpal, Anjali Prakash, Gaurav S Pradhan, Aditi Vidholia, Nishant Nagpal, Sachin S Saboo, David M Kuehn, Ashish Khandelwal
The stomach may be involved by a myriad of pathologies ranging from benign etiologies like inflammation to malignant etiologies like carcinoma or lymphoma. Multidetector computed tomography (MDCT) of the stomach is the first-line imaging for patients with suspected gastric pathologies. Conventionally, CT imaging had the advantage of simultaneous detection of the mural and extramural disease extent, but advances in MDCT have allowed mucosal assessment by virtual endoscopy. Also better three-dimensional (3D) post-processing techniques have enabled more robust and accurate pre-operative planning in patients undergoing gastrectomy and even predict the response to surgery for patients undergoing laparoscopic sleeve gastrectomy for weight-loss...
October 27, 2016: British Journal of Radiology
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