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https://www.readbyqxmd.com/read/28704254/efficacy-and-safety-of-ranibizumab-for-the-treatment-of-choroidal-neovascularization-due-to-uncommon-cause-twelve-month-results-of-the-minerva-study
#1
Timothy Y Y Lai, Giovanni Staurenghi, Paolo Lanzetta, Frank G Holz, Shiao Hui Melissa Liew, Sabine Desset-Brethes, Harry Staines, Philip G Hykin
PURPOSE: To evaluate the efficacy and safety of ranibizumab 0.5 mg in adult patients with choroidal neovascularization because of an uncommon cause enrolled in the 12-month MINERVA study. METHODS: In this Phase III, double-masked study, adult (≥18 years) patients (N = 178) were randomized 2:1 to receive either ranibizumab (n = 119) or sham (n = 59) at baseline and, if needed, at Month 1 and open-label individualized ranibizumab from Month 2. Best-corrected visual acuity change from baseline to Month 2 (primary endpoint) and Month 12, treatment exposure, and safety over 12 months were reported...
July 12, 2017: Retina
https://www.readbyqxmd.com/read/28641290/long-term-follow-up-of-choroidal-neovascularization-due-to-angioid-streaks-with-pro-re-nata-intravitreal-anti-vegf-treatment
#2
Giovanni Giacomelli, Lucia Finocchio, Ilaria Biagini, Andrea Sodi, Vittoria Murro, Ugo Introini, Monica Varano, Francesco Bandello, Ugo Menchini
PURPOSE: To evaluate the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) drugs with a pro re nata (PRN) regimen for the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS). METHODS: This is a retrospective, multicenter, noncomparative case series of consecutive AS eyes affected by treatment-naïve CNV. A complete ophthalmologic examination was performed every 30-45 days after the loading phase, including fluorescein angiography and/or optical coherence tomography...
June 23, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28622313/optical-coherence-tomography-analysis-of-evolution-of-bruch-s-membrane-features-in-angioid-streaks
#3
A Marchese, M Parravano, A Rabiolo, A Carnevali, E Corbelli, M V Cicinelli, M Battaglia Parodi, L Querques, F Bandello, G Querques
PurposeTo describe optical coherence tomography (OCT) features in the Bruch's membrane (BM) of eyes with angioid streaks (AS) and evaluate their evolution over the follow-up.Patients and methodsPatients with AS presenting between March 2016 and September 2016 at two tertiary referral centers were consecutively recruited in this study. Eligibility criteria included prior spectral domain (SD)-OCT images, taken at least 3 months before at the same referral center, with automated eye tracking and image alignment modules...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28574138/detection-of-nonexudative-choroidal-neovascularization-secondary-to-angioid-streaks-using-optical-coherence-tomography-angiography
#4
Konstantinos D Andreanos, Tryfon Rotsos, Chryssanthi Koutsandrea, Georgios D Kymionis, Ilias Georgalas, Ioannis D Ladas
PURPOSE: To present a case of nonexudative choroidal neovascularization secondary to angioid streaks in a patient with pseudoxanthoma elasticum. The lesion was monitored over an 8-month period with the use of optical coherence tomography angiography. METHODS: Case report. RESULTS: The neovascular tissue area increased by 0.160 mm2 over a period of 8 months without any sign of exudation seen on optical coherence tomography or fluorescein angiography...
May 29, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28512425/long-term-follow-up-of-polypoidal-choroidal-vasculopathy-secondary-to-angioid-streaks-treated-by-intravitreal-aflibercept-and-ranibizumab
#5
James G Wong, Katherine Yu Qian
PURPOSE: Angioid streaks (AS) are dehiscences in Bruch's membrane that may be idiopathic or associated with numerous systemic illnesses. Polypoidal choroidal vasculopathy (PCV) is an underdiagnosed exudative chorioretinopathy often characterised by serosanguineous detachments of the pigmented epithelium. The use of the anti-VEGF agents ranibizumab and aflibercept in the management of PCV secondary to AS has not been previously documented. We report 3 patients with active PCV secondary to AS, 1 of which had a family history of PCV secondary to AS, not previously reported in the literature...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28499057/adaptive-optics-scanning-laser-ophthalmoscopy-and-multimodal-imaging-of-peau-d-orange-in-pseudoxanthoma-elasticum
#6
Alex C Onishi, Peter L Nesper, Amani A Fawzi
A 41-year-old male with pseudoxanthoma elasticum who presented with progressive vision loss in his left periphery is discussed. Bilateral angioid streaks, optic disc drusen, choroidal neovascularization, and peau d'orange were present. Imaging of the area with peau d'orange with adaptive optics scanning laser ophthalmoscopy and en face optical coherence tomography at Bruch's membrane (BM) revealed a pattern identical to the patches of peau d'orange visible with conventional fundus imaging techniques. These results show that structural abnormalities at the level of BM, likely a result of calcification, correlate with the characteristic "orange peel" pattern known as peau d'orange...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28486967/pseudoxanthoma-elasticum
#7
REVIEW
Dominique P Germain
Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein leads to ectopic mineralization that is most apparent in the elastic tissues of the skin, eyes and blood vessels. The clinical prevalence of PXE has been estimated at between 1 per 100,000 and 1 per 25,000, with slight female predominance. The first clinical sign of PXE is almost always small yellow papules on the nape and sides of the neck and in flexural areas...
May 10, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28282700/-choroidal-neovascularisation-other-than-typical-neovascular-age-related-macular-degeneration
#8
D Sandner
Choroidal neovascularisation (CNV) in the context of exsudative age-related macular degeneration (nAMD) can be divided into type 1 (occult) and type 2 (classical) membranes. Retinal angiomatous proliferation (RAP) or polypoidal choroidal vasculopathy (PCV) are "rare subtypes" of chorioretinal neovascularisation and are distinguished by their distinct morphology and the sometimes worse response to therapy. Chorioretinal anastomosis, severe exsudates with serosanguinous pigment epithelial detachment and, in PCV, orange-red lesions in the papillomacular bundle can be diagnostic...
March 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28278344/multiple-choroidal-ruptures-in-a-patient-with-angioid-streaks
#9
Rupesh Agrawal, Ana Pajtler Rosar, Alenka Lavric
No abstract text is available yet for this article.
March 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28031699/long-term-follow-up-of-patients-with-choroidal-neovascularization-due-to-angioid-streaks
#10
Maria Guadalupe Martinez-Serrano, Abelardo Rodriguez-Reyes, Jose Luis Guerrero-Naranjo, Guillermo Salcedo-Villanueva, Jans Fromow-Guerra, Gerardo García-Aguirre, Virgilio Morales-Canton, Raul Velez-Montoya
BACKGROUND: The following case series describes the long-term anatomical and functional outcome of a group of seven patients with choroidal neovascularization (CNV), secondary to angioid streaks (AS), who were treated with antiangiogenic drugs in a pro re nata (PRN) regimen. After the 4-year mark, visual acuity tends to return to pretreatment level. Treatment delays and lack of awareness and self-referral by the patients are believed to be the cause of the PRN regimen failure. PURPOSE: To assess the long-term outcomes (>4 years) of patients with CNV due to AS treated with a PRN regimen of antiangiogenic...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27959968/enhanced-visualization-of-subtle-outer-retinal-pathology-by-en-face-optical-coherence-tomography-and-correlation-with-multi-modal-imaging
#11
Danuta M Sampson, David Alonso-Caneiro, Avenell L Chew, Tina Lamey, Terri McLaren, John De Roach, Fred K Chen
PURPOSE: To present en face optical coherence tomography (OCT) images generated by graph-search theory algorithm-based custom software and examine correlation with other imaging modalities. METHODS: En face OCT images derived from high density OCT volumetric scans of 3 healthy subjects and 4 patients using a custom algorithm (graph-search theory) and commercial software (Heidelberg Eye Explorer software (Heidelberg Engineering)) were compared and correlated with near infrared reflectance, fundus autofluorescence, adaptive optics flood-illumination ophthalmoscopy (AO-FIO) and microperimetry...
2016: PloS One
https://www.readbyqxmd.com/read/27847633/automated-macular-choroidal-thickness-measurement-by-swept-source-optical-coherence-tomography-in-pseudoxanthoma-elasticum
#12
Rosa Dolz-Marco, María Andreu-Fenoll, Pablo Hernández-Martínez, M Dolores Pinazo-Durán, Roberto Gallego-Pinazo
INTRODUCTION: Pseudoxanthoma elasticum (PXE) typically involves elastic fibers in blood vessels and Bruch membrane. Our purpose was to analyze retinal and choroidal macular thickness in patients with angioid streaks due PXE compared with a control group. METHODS: Best-corrected visual acuity (BCVA), axial length (AL), and macular swept-source optical coherence tomography were obtained. Automated segmentations of the retina and the choroid were used to obtain the corresponding thickness values...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27847624/prevalence-of-outer-retinal-tubulation-in-eyes-with-choroidal-neovascularization
#13
Richard Geraldo Giachetti Filho, Leandro Cabral Zacharias, Thaís Vera Monteiro, Rony Carlos Preti, Sérgio Gianoti Pimentel
BACKGROUND: Outer retinal tubulations (ORTs) are branching tubular structures located in the outer nuclear layer of the retina. The goal of this study is to determine the prevalence of ORTs observed in eyes with choroidal neovascularization (CNV) undergoing treatment with anti-angiogenic intravitreous injection (IVI) with anti-VEGF (vascular endothelial growth factor) at the Ophthalmology Department of a tertiary hospital in São Paulo, Brazil. METHODS: This is a descriptive study based on medical charts and Spectral-domain Optical Coherence Tomography (Sd-OCT) scans of 142 patients (158 eyes) treated between 2012 and 2014 with IVI of anti-VEGF for CNV...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27800246/comet-lesions-in-patients-with-pseudoxanthoma-elasticum
#14
Sinan Tatlıpınar, Berna Şahan, Muhsin Altunsoy
Pseudoxanthoma elasticum (PXE) is a genetic multisystemic disorder affecting the skin, eyes and cardiovascular system. Basic fundoscopic findings in PXE result from Bruch's membrane involvement. The most important fundoscopic findings are angioid streaks. Other significant ocular findings are peau d'orange appearance, optic disc drusen, pattern dystrophy-like macular appearance, comet lesions, and choroidal neovascularization. Comet lesions are a pathognomonic ocular finding for PXE. The presence of both angioid streaks in the fundus and typical skin lesions should alert clinicians to PXE...
December 2015: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27768638/bilateral-choroidal-neovascularization-in-a-patient-with-beta-thalassemia-major-and-its-management
#15
Mohammad Yaser Kiarudi, Kaveh Fadakar, Ebrahim Mousavi
PURPOSE: To describe a case of bilateral choroidal neovascularization in a patient with beta-thalassemia major and an interventional therapeutic attempt. METHOD: Retrospective case report. RESULT: A known case of beta-thalassemia major presented with gradual vision loss. Fundoscopy revealed bilateral macular edema accompanied by intraretinal hemorrhages. Optical coherence tomography and fluorescein angiography were compatible with the diagnosis of choroidal neovascularization...
October 20, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27697324/angioid-streaks-in-the-fundus-of-a-13-year-old-girl
#16
Ilias Georgalas, George Kymionis, Dimitris Papakonstantinou, Theodore Paraskevopoulos
No abstract text is available yet for this article.
September 30, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27617603/pseudoxanthoma-elasticum-report-of-a-case-with-a-novel-gene-mutation
#17
Nicole Meunier, Lisa Zaleski
Pseudoxanthoma Elasticum (PXE) is a rare autosomal recessive disorder characterized by progressive calcification and fragmentation of elastic fibers in the skin, eyes, and cardiovascular system. PXE is caused by mutations in the ABCC6 gene but the specific pathophysiology of this condition remains unknown. We present a case of a patient who was diagnosed with PXE after experiencing vision loss following minor ocular trauma. Our patient had angioid streaks in her right eye, skin laxity of the bilateral dorsal hands, and yellow papules coalescing on the posterior neck...
June 16, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27614462/angioid-streaks-in-aagenaes-syndrome
#18
Viara Shoumnalieva-Ivanova, Ivan Tanev, Yani Zdravkov, Simeon Monov, Russka Shumnalieva
Aagenaes syndrome, also called lymphoedema cholestasis syndrome 1 (LSC1), is characterized by neonatal intrahepatic cholestasis, often lessening and becoming intermittent with age and severe chronic lymphoedema, mainly affecting the lower extremities. The condition is autosomal recessively inherited, and the gene is located on chromosome 15q. The locus, LCS1, was mapped to a 6.6 cM region on chromosome 15. Angioid streaks are visible irregular crack-like dehiscences in bruch's membrane that are associated with atrophic degeneration of the overlying retinal pigment epithelium...
September 10, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27463636/silent-polypoidal-choroidal-vasculopathy-in-a-patient-with-angioid-streaks
#19
Zafer Cebeci, Serife Bayraktar, Merih Oray, Nur Kir
We present a case of silent polypoidal choroidal vasculopathy (PCV) in a patient with angioid streaks. PCV was detected during a routine ophthalmic examination and confirmed by fluorescein angiography, indocyanine green angiography, and optical coherence tomography. After 2 years of follow-up, the PCV remained silent without any complications. We report this rare coexistence and review literature on this topic.
May 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27457484/intravitreal-ranibizumab-for-choroidal-neovascularization-in-a-patient-with-angioid-streaks-and-multiple-evanescent-white-dots
#20
Alfredo Pece, Davide Allegrini, Stelios Kontadakis, Giuseppe Querques, Luca Rossetti
BACKGROUND: To report a patient with angioid streaks (ASs) and coincident multiple evanescent white dot syndrome (MEWDS) who developed choroidal neovascularization (CNV). CASE PRESENTATION: A 20-year-old woman presented with reduced vision (20/100) in her left eye (LE). Based on a complete ophthalmologic examination the patient was diagnosed with ASs and coincident MEWDS. Two weeks later best-corrected visual acuity (BCVA) improved up to 20/25 and the MEWDS findings almost disappeared...
July 26, 2016: BMC Ophthalmology
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