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https://www.readbyqxmd.com/read/29341029/in-vitro-and-in-situ-absorption-and-metabolism-of-sesquiterpenes-from-petasites-hybridus-extracts
#1
Lucia Disch, Kristina Forsch, Beate Siewert, Jürgen Drewe, Gert Fricker
Petasites hybridus extract is used in the treatment of seasonal allergic rhinitis. The aim of this study was to evaluate the active constituent petasin and its isomers isopetasin and neopetasin (petasins) in the P. hybridus extract Ze 339 for liberation, dissolution, absorption, and metabolism. The determination of pH-dependent thermodynamic solubility was performed via the shake-flask method. Petasins exhibited a low solubility that was pH independent. In vivo, the concentration of solute drugs is decreased continuously by intestinal absorption...
January 16, 2018: Planta Medica
https://www.readbyqxmd.com/read/29311532/the-formation-of-the-military-medical-system-of-the-korean-people-s-army-and-the-military-medical-officer
#2
Seonho Kim
The military medical system of the Korean People's Army (KPA) first appeared in August 1946 when a central military hospita was established at the headquarters. Inside the KPA, the military medical and veteran services were first established in February 1948. The military medical officers of the KPA were those who were initially engaged in North Korea's health care sector. Most of the early military medical officers were those who had been trained in the Japanese medical system before liberation and were surgeons...
December 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/29309173/-holy-trinity-monument-in-the-city-of-osijek
#3
Bruno Atalić
Plague was one of the most deadly epidemic diseases of the Baroque period. Responses to it were not only medical, but religious as well. A good example of the latter is the Most Holy Trinity monument in the city of Osijek, which was in the 18th century the biggest town of the Kingdom of Slavonia and today is the regional centre in the Republic of Croatia. The monument was erected between 1729 and 1730 on the main square of the Osijek military fortress Tvrđa by the widow of the General Maksimilijan Petraš who died during the 1728 plague epidemic...
December 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/29298708/case-study-of-a-user-driven-prosthetic-arm-design-bionic-hand-versus-customized-body-powered-technology-in-a-highly-demanding-work-environment
#4
Wolf Schweitzer, Michael J Thali, David Egger
BACKGROUND: Prosthetic arm research predominantly focuses on "bionic" but not body-powered arms. However, any research orientation along user needs requires sufficiently precise workplace specifications and sufficiently hard testing. Forensic medicine is a demanding environment, also physically, also for non-disabled people, on several dimensions (e.g., distances, weights, size, temperature, time). METHODS: As unilateral below elbow amputee user, the first author is in a unique position to provide direct comparison of a "bionic" myoelectric iLimb Revolution (Touch Bionics) and a customized body-powered arm which contains a number of new developments initiated or developed by the user: (1) quick lock steel wrist unit; (2) cable mount modification; (3) cast shape modeled shoulder anchor; (4) suspension with a soft double layer liner (Ohio Willowwood) and tube gauze (Molnlycke) combination...
January 3, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29278638/attitudes-of-students-of-medicine-university-of-mostar-according-to-induced-abortion
#5
Zoran Trninić, Marija Bender, Nikica Šutalo, Davorin Kozomara, Valentina Lasić, Danijel Bevanda, Gordan Galić
BACKGROUND: Aim of this study was to establish attitudes of medical students on induced abortion and connection of those attitudes with religiousness, length of their studies, sex and various circumstances of pregnancy. SUBJECTS AND METHODS: In total, 148 students of the first, second, fifth and sixth year of medical faculty participated in the research. The study was conducted at the Medical Faculty of the University in Mostar. While collecting the data, we used a survey taken over from literature...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29178797/unprotected-indazoles-are-resilient-to-ring-opening-isomerization-a-case-study-on-catalytic-c-s-couplings-in-the-presence-of-strong-base
#6
Jacob M Ganley, Charles S Yeung
Indazoles represent a privileged scaffold in medicinal chemistry. In the presence of strong base, however, N-protected indazoles are prone to an undesirable ring-opening reaction to liberate ortho-aminobenzonitriles. By employing unprotected indazoles with a free N-H bond, isomerization is averted since the heterocycle is deprotonated in situ. We herein report a functional group tolerant and robust C-S couplings of bromo-indazoles with thiols of varying electronic nature in the presence of lithium bis(trimethylsilyl)amide at elevated temperatures...
November 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29171151/live-cell-microrna-imaging-via-mno2-nanosheets-mediated-dd-a-hybridization-chain-reaction
#7
Min Ou, Jin Huang, Xiaohai Yang, Xiaoxiao He, Ke Quan, Yanjing Yang, Nuli Xie, Jing Li, Kemin Wang
Innovative techniques to visualize native microRNAs (miRNAs) in live cells can dramatically impact current research on the roles of miRNAs in biology and medicine. Here, we report a novel approach for live cell miRNAs imaging through biodegradable MnO2 nanosheets mediated "DD-A" FRET hybridization chain reaction (HCR). The MnO2 nanosheets can adsorb DNA hairpin probes and deliver them into live cells. After entering cells, the MnO2 nanosheets are degradated by cellular GSH. Then, the target miR-21 triggers cascaded assembly of the liberated hairpin probes into long dsDNA polymers, which brings each two FAMs (Donor) and one TAMRA (Acceptor) into close proximity to generate significantly enhanced "DD-A" FRET signals, which is discovered and proved by our previous report...
November 23, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29092791/editorial-for-the-special-issue-on-behavior-change-health-and-health-disparities-2017
#8
EDITORIAL
Stephen T Higgins
This Special Issue of Preventive Medicine (PM) is the 4th in a series on behavior change, health, and health disparities, a topic of critical importance to improving U.S. population health. The U.S. ranks near the bottom on measures of population health relative to other industrialized countries despite spending orders of magnitude more on health care than any other nation. Population health experts agree that the area of personal behavior, or lifestyle, such as substance abuse, physical inactivity/obesity, and non-adherence with medical regimens is the single largest contributor to this situation...
October 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29032677/ultrasensitive-ratiometric-homogeneous-electrochemical-microrna-biosensing-via-target-triggered-ru-iii-release-and-redox-recycling
#9
Panpan Gai, Chengcheng Gu, Haiyin Li, Xinzhi Sun, Feng Li
A new label-free and enzyme-free ratiometric homogeneous electrochemical microRNA biosensing platform was constructed via target-triggered Ru(III) release and redox recycling. To design the effective ratiometric dual-signal strategy, [Ru(NH3)6](3+) (Ru(III)), as one of the electroactive probes, was ingeniously entrapped in the pores of the positively charged mesoporous silica nanoparticle (PMSN), and another electroactive probe, [Fe(CN)6](3-) (Fe(III)), was selected to facilitate Ru(III) redox recycling due to its distinctly separated reduction potential and different redox properties...
October 31, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29019798/the-return-to-literature-making-doctors-matter-in-the-new-era-of-medicine
#10
Daniel Marchalik
The rapid explosion of medical knowledge of the 19th and 20th centuries required a transformation in medical education, which, to that point, had been marked by low educational standards. To combat the lack of regulation, the 1910 Flexner Report recommended sweeping reforms. By 1930, students hoping to enroll in a medical school would need to complete courses in chemistry, physics, and biology, leaving little room for the liberal arts.Medicine is once again changing. The impact of artificial intelligence is being felt across all medical fields, and the nature of physicians' jobs in the new landscape of intelligent machines will inevitably also have to change...
December 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28994286/novel-derivative-of-bardoxolone-methyl-improves-safety-for-the-treatment-of-diabetic-nephropathy
#11
Zhangjian Huang, Yi Mou, Xiaojun Xu, Di Zhao, Yisheng Lai, Yuwen Xu, Cen Chen, Ping Li, Sixun Peng, Jide Tian, Yihua Zhang
Currently, no effective and safe medicines are available to treat diabetic nephropathy (DN). Bardoxolone methyl (CDDO-Me) has displayed promising anti-DN activity as well as serious side effects in clinical trials, probably because the highly reactive α-cyano-α,β-unsaturated ketone (CUK) in ring A of CDDO-Me can covalently bind to thiol functionalities in many biomacromolecules. In this study, we designed and synthesized a γ-glutamyl transpeptidase (GGT)-based and CUK-modified derivative of CDDO-Me (2) to address this issue...
November 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28991760/centenary-of-the-birth-of-academician-prof-dr-isak-tadzer-founder-of-the-pathophysiology-and-nuclear-medicine-in-macedonia
#12
Borislav Karanfilski
Academician Prof. Dr. Isak Tadzer was born a hundred years ago on December 24, 1916 in Sofia. He completed the primary and secondary education at the German College in Sofia. In 1935 he began his studies at the Medical Faculty in Vienna, which he had to stop because of the annexation of Austria to Germany in 1938. He returned to Bulgaria where he continued his studies and graduated from the Medical Faculty in Sofia in 1941. During the War, 1941-1944, he was forcedly mobilized and he worked as a doctor in several villages...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28975944/multifunctional-gold-nanoparticle-layers-for-controllable-capture-and-release-of-proteins
#13
Zhenhua Li, Feng Liu, Yuqi Yuan, Jingxian Wu, Hongwei Wang, Lin Yuan, Hong Chen
Protein modified functional surfaces have been applied extensively in the field of biomaterials and medicine. Regulation of the amount and activity of proteins on the material surface is always a challenge and a key research issue. A multifunctional micro/nano-composite based surface system for efficient controllable capture and release of proteins is proposed and studied in the present paper. This novel system contains (1) gold nanoparticles (AuNPs) co-modified with an enzyme and poly(methacrylic acid) (PMAA), e...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28951049/an-easy-and-fast-adenosine-5-diphosphate-quantification-procedure-based-on-hydrophilic-interaction-liquid-chromatography-high-resolution-tandem-mass-spectrometry-for-determination-of-the-in-vitro-adenosine-5-triphosphatase-activity-of-the-human-breast-cancer
#14
Lea Wagmann, Hans H Maurer, Markus R Meyer
Interactions with the human breast cancer resistance protein (hBCRP) significantly influence the pharmacokinetic properties of a drug and can even lead to drug-drug interactions. As efflux pump from the ABC superfamily, hBCRP utilized energy gained by adenosine 5'-triphosphate (ATP) hydrolysis for the transmembrane movement of its substrates, while adenosine 5'-diphosphate (ADP) and inorganic phosphate were released. The ADP liberation can be used to detect interactions with the hBCRP ATPase. An ADP quantification method based on hydrophilic interaction liquid chromatography (HILIC) coupled to high resolution tandem mass spectrometry (HR-MS/MS) was developed and successfully validated in accordance to the criteria of the guideline on bioanalytical method validation by the European Medicines Agency...
September 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28872043/representations-of-their-own-sexuality-and-aging-body-by-old-people-phenomenological-and-psychodynamic-approach
#15
Lucile Meyrignac, Noureddine Bouati, Alain Sagne, Gaëtan Gavazzi, Anne-Claire Zipper
The sexuality of the elderly is rarely mentioned in general medicine although it holds an important place in many old people's life, and sexual well-being is a part of the global well-being according to the World Health Organization. To explore the representations of their own sexuality and aging body by the elderly. Qualitative study using semi-structured interviews in 15 healthy elderly people over 65 years of age, living at home. In-depth interviews were transcribed and submitted to qualitative content using a phenomenological and a psychodynamic analysis...
September 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28804171/threats-posed-by-stockpiles-of-expired-pharmaceuticals-in-low-and-middle-income-countries-a-ugandan-perspective
#16
Pakoyo Fadhiru Kamba, Munanura Edson Ireeta, Sulah Balikuna, Bruhan Kaggwa
In some low- and middle-income countries, the national stores and public-sector health facilities contain large stocks of pharmaceuticals that are past their expiry dates. In low-income countries like Uganda, many such stockpiles are the result of donations. If not adequately monitored or regulated, expired pharmaceuticals may be repackaged and sold as counterfeits or be dumped without any thought of the potential environmental damage. The rates of pharmaceutical expiry in the supply chain need to be reduced and the disposal of expired pharmaceuticals needs to be made both timely and safe...
August 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28770093/the-clinical-practice-guideline-for-the-management-of-ards-in-japan
#17
Satoru Hashimoto, Masamitsu Sanui, Moritoki Egi, Shinichiro Ohshimo, Junji Shiotsuka, Ryutaro Seo, Ryoma Tanaka, Yu Tanaka, Yasuhiro Norisue, Yoshiro Hayashi, Eishu Nango
BACKGROUND: The Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine provide here a clinical practice guideline for the management of adult patients with ARDS in the ICU. METHOD: The guideline was developed applying the GRADE system for performing robust systematic reviews with plausible recommendations. The guideline consists of 13 clinical questions mainly regarding ventilator settings and drug therapies (the last question includes 11 medications that are not approved for clinical use in Japan)...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28747360/cannabinoids-and-the-kidney-effects-in-health-and-disease
#18
Frank Park, Praveen K Potukuchi, Hamid Moradi, Csaba P Kovesdy
Consumption of cannabis and various related products (cannabinoids) for both medicinal and recreational use is gaining popularity. Furthermore, regulatory changes are fostering a cultural shift towards increasing liberalization of cannabis use, thereby increasing the likelihood of even larger numbers of individuals being exposed in the future. The two different types of receptors (CB1 and CB2) that are activated by the pharmacologically active ingredients of cannabis are found in numerous tissues, including the kidneys...
July 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28682957/the-new-world-health-organization-recommendations-on-perioperative-administration-of-oxygen-to-prevent-surgical-site-infections-a-dangerous-reductionist-approach
#19
Manuel Wenk, Hugo Van Aken, Alexander Zarbock
In October 2016, the World Health Organization (WHO) published recommendations for preventing surgical site infections (SSIs). Among those measures is a recommendation to administer oxygen at an inspired fraction of 80% intra- and postoperatively for up to 6 hours. SSIs have been identified as a global health problem, and the WHO should be commended for their efforts. However, this recommendation focuses only on the patient's "wound," ignores other organ systems potentially affected by hyperoxia, and may ultimately worsen patient outcomes...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28634521/a-review-of-echocardiograms-in-hypertensive-patients-greater-than-60-years-in-a-community-based-family-medicine-program
#20
Shideh Doroudi, Michael D DeLisi, Vincent A DeBari
Background: Heart disease as a result of Hypertension is known to occur. Anatomical and functional changes of the heart can easily be detected by echocardiography, which is a safe and readily available study. Objectives: The aims of this study were to evaluate the prevalence of common echocardiographic changes in chronic hypertensive patients and to compare these changes in male and female populations. Design/methods: The study was a community-based cross-sectional study, on 227 hypertensive patients, 60 years and older, seen in St...
January 2017: Journal of Community Hospital Internal Medicine Perspectives
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