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Liberation medicine

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https://www.readbyqxmd.com/read/27908256/a-review-on-nano-antimicrobials-metal-nanoparticles-methods-and-mechanisms
#1
Edris Hoseinzadeh, Pouran Makhdoumi, Parisa Taha, John Stelling, Hooshyar Hossini, Mohammad Amjad Kamal, Ghulam Md Ashraf
Nanotechnology is a scientific and engineering technology conducted at the Nano-scale, such as in the fields of compound fabric manufacturing, food processing, agricultural processing, and engineering, as well as in medical and medicinal application. In recent decade, nanomaterial applications for antimicrobial works have been interested by many researchers. Available reports show that some of the metal oxide Nanoparticles including; Al2O3, TiO2, ZnO, CuO, Co3O4, In2O3, MgO, SiO2, ZrO2, Cr2O3, Ni2O3, Mn2O3, CoO, and Nickel oxide have toxicity toward several microorganisms and they could successfully kill numerous bacteria...
December 1, 2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/27832660/global-overexpression-of-et-1-decreases-blood-pressure-a-systematic-review-and-meta-analysis-of-et-1-transgenic-mice
#2
Yong Ping Lu, Oleg Tsuprykov, Nicolas Vignon-Zellweger, Susi Heiden, Berthold Hocher
BACKGROUND/AIMS: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially counteracting mechanisms on blood pressure, a systematic meta-analysis was performed. METHODS: Based on the principles of Cochrane systematic reviews, we searched in major literature databases - MEDLINE (PubMed), Embase, Google Scholar, and the China Biological Medicine Database (CBM-disc) - for articles relevant to the topic of the blood pressure phenotype of endothelin-1 transgenic (ET-1+/+) mice from January 1, 1988 to March 31, 2016...
November 11, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27829710/early-norepinephrine-decreases-fluid-and-ventilatory-requirements-in-pediatric-vasodilatory-septic-shock
#3
Suchitra Ranjit, Rajeswari Natraj, Sathish Kumar Kandath, Niranjan Kissoon, Balasubramaniam Ramakrishnan, Paul E Marik
AIMS: We previously reported that vasodilatation was common in pediatric septic shock, regardless of whether they were warm or cold, providing a rationale for early norepinephrine (NE) to increase venous return (VR) and arterial tone. Our primary aim was to evaluate the effect of smaller fluid bolus plus early-NE versus the American College of Critical Care Medicine (ACCM) approach to more liberal fluid boluses and vasoactive-inotropic agents on fluid balance, shock resolution, ventilator support and mortality in children with septic shock...
October 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27818329/liberation-from-mechanical-ventilation-in-critically-ill-adults-executive-summary-of-an-official-american-college-of-chest-physicians-american-thoracic-society-clinical-practice-guideline
#4
Gregory A Schmidt, Timothy D Girard, John P Kress, Peter E Morris, Daniel R Ouellette, Waleed Alhazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miguel Ferrer, Gilles L Fraser, Michelle Gong, Catherine L Hough, Sangeeta Mehta, Rahul Nanchal, Sheena Patel, Amy J Pawlik, Curtis N Sessler, William Schweickert, Thomas Strøm, Kevin C Wilson, Jonathon D Truwit
BACKGROUND: This clinical practice guideline addresses six questions related to liberation from mechanical ventilation in critically ill adults. It is the result of a collaborative effort between the American Thoracic Society (ATS) and American College of Chest Physicians (CHEST). METHODS: A multi-disciplinary panel posed six clinical questions in a Population, Intervention, Comparator and Outcomes (PICO) format. A comprehensive literature search and evidence synthesis was performed for each question, which included appraising the quality of evidence using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach...
November 3, 2016: Chest
https://www.readbyqxmd.com/read/27817090/optimization-of-physical-conditions-for-the-aqueous-extraction-of-antioxidant-compounds-from-ginger-zingiber-officinale-applying-a-box-behnken-design
#5
Juan Ramírez-Godínez, Judith Jaimez-Ordaz, Araceli Castañeda-Ovando, Javier Añorve-Morga, Verónica Salazar-Pereda, Luis Guillermo González-Olivares, Elizabeth Contreras-López
Since ancient times, ginger (Zingiber officinale) has been widely used for culinary and medicinal purposes. This rhizome possesses several chemical constituents; most of them present antioxidant capacity due mainly to the presence of phenolic compounds. Thus, the physical conditions for the optimal extraction of antioxidant components of ginger were investigated by applying a Box-Behnken experimental design. Extracts of ginger were prepared using water as solvent in a conventional solid-liquid extraction. The analyzed variables were time (5, 15 and 25 min), temperature (20, 55 and 90 °C) and sample concentration (2, 6 and 10 %)...
November 5, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27813455/the-liber-compostelle-attributed-to-friar-bonaventura-of-iseo-the-textual-tradition-of-a-thirteenth-century-alchemical-encyclopedia
#6
Maria Chiara Succurro
The Liber Compostelle is an alchemical encyclopedia associated with the name of Bonaventura of Iseo, a friar of great reputation and an esteemed preacher around the middle of the thirteenth century. It is one of the first works to show an interest in medicine and pharmacology among the Friars Minor. Despite its importance, the Liber Compostelle has never been published. This article investigates the textual history of the treatise, and the problems of its authorship and dating, examining the eight manuscripts that contain the Liber...
November 4, 2016: Ambix
https://www.readbyqxmd.com/read/27802876/something-for-pain-responsible-opioid-use-in-emergency-medicine
#7
Reuben J Strayer, Sergey M Motov, Lewis S Nelson
The United States is currently experiencing a public health crisis of opioid addiction, which has its genesis in an industry marketing effort that successfully encouraged clinicians to prescribe opioids liberally, and asserted the safety of prescribing opioids for chronic non-cancer pain, despite a preponderance of evidence demonstrating the risks of dependence and misuse. The resulting rise in opioid use has pushed drug overdose deaths in front of motor vehicle collisions to become the leading cause of accidental death in the country...
October 24, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27762608/official-executive-summary-of-an-american-thoracic-society-american-college-of-chest-physicians-clinical-practice-guideline-liberation-from-mechanical-ventilation-in-critically-ill-adults
#8
Gregory A Schmidt, Timothy D Girard, John P Kress, Peter E Morris, Daniel R Ouellette, Waleed Alhazzani, Suzanne M Burns, Scott K Epstein, Andres Esteban, Eddy Fan, Miquel Ferrer, Gilles L Fraser, Michelle Gong, Catherine Hough, Sangeeta Mehta, Rahul Nanchal, Sheena Patel, Amy J Pawlik, Curtis N Sessler, Thomas Strøm, William Schweickert, Kevin C Wilson, Jonathon D Truwit
BACKGROUND: This clinical practice guideline addresses six questions related to liberation from mechanical ventilation in critically ill adults. It is the result of a collaborative effort between the American Thoracic Society (ATS) and American College of Chest Physicians (CHEST). METHODS: A multi-disciplinary panel posed six clinical questions in a Population, Intervention, Comparator and Outcomes (PICO) format. A comprehensive literature search and evidence synthesis was performed for each question, which included appraising the certainty in the evidence (i...
October 20, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27732721/clinical-practice-guidelines-from-the-aabb-red-blood-cell-transfusion-thresholds-and-storage
#9
Jeffrey L Carson, Gordon Guyatt, Nancy M Heddle, Brenda J Grossman, Claudia S Cohn, Mark K Fung, Terry Gernsheimer, John B Holcomb, Lewis J Kaplan, Louis M Katz, Nikki Peterson, Glenn Ramsey, Sunil V Rao, John D Roback, Aryeh Shander, Aaron A R Tobian
Importance: More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain. Objective: To provide recommendations for the target hemoglobin level for RBC transfusion among hospitalized adult patients who are hemodynamically stable and the length of time RBCs should be stored prior to transfusion. Evidence Review: Reference librarians conducted a literature search for randomized clinical trials (RCTs) evaluating hemoglobin thresholds for RBC transfusion (1950-May 2016) and RBC storage duration (1948-May 2016) without language restrictions...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27713883/epidemiologic-trends-of-sepsis-in-western-countries
#10
Alejandro Suarez De La Rica, Fernando Gilsanz, Emilio Maseda
Since the American College of Chest Physicians (ACCP) and the Society of Critical care Medicine (SCCM) published the first consensus definition of syndromes related to sepsis in 1992, the knowledge of epidemiology of sepsis has clearly improved, although no prospective studies have been performed to analyse the incidence of sepsis in general population. There are differences in epidemiologic trends in sepsis between western countries and low-income and middle-income countries. In the United States (US), most of epidemiologic studies have been based on large, administrative databases, reporting an increase in the incidence of severe sepsis over years...
September 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27676846/hemipass-87-three-years-of-experience-of-a-mobile-home-team-care-for-post-stroke-patients-improved-cooperation-between-stakeholders-to-increase-patients-services
#11
David Bernikier, Katia Raetz, David Chaparro, Jessica Delvert, Jean-Christophe Daviet, Jean Yves Salle
OBJECTIVE: HEMIPASS is a post-stroke interdisciplinary mobile home team care, which aims to provide home care services for post-stroke patients. Describe the evolution of HEMIPASS program over the past three years by looking at its level of activities. The hypothesis is that the HEMIPASS program is more in demand by liberal sector than hospital services; indeed, it increases its efficacy over time. MATERIALS/PATIENTS AND METHODS: Retrospective study design conducted from 2013 to 2015, involving all post-stroke patients enrolled in HEMIPASS program during this period...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676820/evaluation-of-disabilities-and-rehabilitation-needs-after-critical-illness-impact-of-an-intensive-care-unit-follow-up-clinic-in-the-university-hospital-of-angers
#12
Tiphaine Bourseau, Flavie Fremondière, Valérie Dubus, Bénédicte Gohier, Dewi Le Gal, Fabien Cave, Isabelle Richard, Nicolas Lerolle
OBJECTIVE: After critical illness, some survivors experience long-term physical, functional, neurocognitive and/or mental health impairments, which has been termed "Post-Intensive Care syndrome" (PICS) [1]. A specific follow-up is required and many specialized follow-up clinics have been created both abroad and in France. The aim of this study is to evaluate long-term outcomes after critical illness, through the International Classification of Functioning, Disability and Health, and to analyse rehabilitation needs after intensive care unit (ICU) discharge...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27631841/hypernatremia-and-copeptin-levels-in-the-elderly-hospitalized-patient
#13
Michal Liber, Moshe Sonnenblick, Gabriel Munter
OBJECTIVE: Elderly patients have a high prevalence of hypernatremia. The aim of this study was to determine demographic and clinical characteristics of the elderly hypernatremic patient hospitalized in the internal medicine ward, and to enhance understanding of the role of ADH secretion in the pathogenesis of hypernatremia. METHODS: Case-control study performed in an Internal Medicine ward in a University affiliated hospital. 33 elderly hypernatremic patients (admission sodium>150 meq/l, age>70) compared to 34 normonatremic patients...
September 15, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27601600/response-to-why-medical-professionals-have-no-moral-claim-to-conscientious-objection-accommodation-in-liberal-democracies-by-schuklenk-and-smalling
#14
Shimon M Glick, Alan Jotkowitz
The recent essay by Schuklenk and Smalling opposing respect for physicians' conscientious objections to providing patients with medical services that are legally permitted in liberal democracies is based on several erroneous assumptions. Acting in this manner would have serious harmful effects on the ethos of medicine and of bioethics. A much more nuanced and balanced position is critical in order to respect physicians' conscience with minimal damage to patients' rights.
September 6, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27544212/zebrafish-a-complete-animal-model-to-enumerate-the-nanoparticle-toxicity
#15
REVIEW
Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, Sang-Soo Lee
Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range of industries, such as medicine, electronics and chemistry. In the current era, the commercial transition of nanotechnology from research level to industrial level is stimulating the world's total economic growth. However, commercialization of nanoparticles might offer possible risks once they are liberated in the environment. In recent years, the use of zebrafish (Danio rerio) as an established animal model system for nanoparticle toxicity assay is growing exponentially...
2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27543773/potent-effects-of-alkaloid-rich-extract-from-huperzia-selago-against-sodium-nitroprusside-evoked-pc12-cells-damage-via-attenuation-of-oxidative-stress-and-apoptosis
#16
A M Lenkiewicz, G A Czapski, H Jęsko, A Wilkaniec, W Szypuła, A Pietrosiuk, A M Uszyńska, A Adamczyk
Imbalance between production and scavenging of free radicals and other reactive oxygen species (ROS) is a component of many diseases, but it is especially important in aging-related diseases of the central nervous system. Oxidative stress-induced neuronal dysfunction plays an important role in the pathomechanism of neurodegenerative disorders, including Alzheimer's and Parkinson's disease. Experimental data showed that free radical scavengers may protect the brain against oxidative modifications. The need for efficient and safe antioxidants with therapeutic potential stimulated the rise of interest in the medicinal plant products, which are a rich source of phytochemicals possessing biological activity...
2016: Folia Neuropathologica
https://www.readbyqxmd.com/read/27521884/enhanced-recovery-pathway-in-gynecologic-surgery-improving-outcomes-through-evidence-based-medicine
#17
REVIEW
Eleftheria Kalogera, Sean C Dowdy
A paucity of data exists regarding traditional perioperative practices (bowel preparation, NPO at midnight, liberal narcotics, PCA use, liberal fluids, prolonged bowel and bed rest). Enhanced Recovery after Surgery (ERAS) is an evidence-based approach to peri-operative care associated with improved outcomes including earlier return of gastrointestinal function, reduced opioid use, shorter hospital stay, and substantial cost reductions with stable complication and readmission rates. Basic principles include patient education, minimizing preoperative fasting, avoiding bowel preparation, preemptive analgesia, nausea/vomiting prophylaxis, perioperative euvolemia, no routine use of drain and nasogastric tubes, early mobilization, oral intake, and catheter removal, non-opioid analgesics, and preemptive laxatives...
September 2016: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/27519573/stakeholders-expectations-and-perceived-effects-of-the-pharmacy-ownership-liberalization-reform-in-sweden-a-qualitative-interview-study
#18
Kristin Wisell, Ulrika Winblad, Sofia Kälvemark Sporrong
BACKGROUND: Reforms in the health-care sector, including the pharmacy sector, can have different rationales. The Swedish pharmacies were prior to 2009 organized in a state-owned monopoly. In 2009, a liberalization of the ownership took place, in which a majority of the pharmacies were sold to private owners. The rationales for this liberalization changed profoundly during the preparatory work, making it probable that other rationales than the ones first expressed existed. The aim of this study was to explore the underlying rationales (not stated in official documents) for the liberalization in the Swedish pharmacy sector, and also to compare the expectations with the perceived outcomes...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27512092/towards-a-structure-of-feeling-abjection-and-allegories-of-disease-in-science-fiction-mutation-films
#19
Frances Pheasant-Kelly
This article considers differences between the representation of mutation in science fiction films from the 1950s and the present, and identifies distinctive changes over this time period, both in relation to the narrative causes of genetic disruption and in the aesthetics of its visual display. Discerning an increasingly abject quality to science fiction mutations from the 1970s onwards-as a progressive tendency to view the physically opened body, one that has a seemingly fluid interior-exterior reversal, or one that is almost beyond recognition as humanoid-the article connects a propensity for disgust to the corresponding socio-cultural and political zeitgeist...
August 10, 2016: Medical Humanities
https://www.readbyqxmd.com/read/27486709/-polonia-medyczna-struktura-wsp%C3%A3-%C3%A5-czesno%C3%A5-%C3%A4-i-przysz%C3%A5-o%C3%A5-%C3%A4
#20
EDITORIAL
Marek Rudnicki
It is estimated that approximately 20-25 000 polish physicians practice medicine in different countries outside of Poland, enriching medical workforces in their newly elected countries. The composition of this group, known as "Medical Polonia", has been changing from post Second World War emigration, resulting from the war and its political consequences, thru the next large wave of physicians leaving the communist country in 1980's. The last large group of Polish physicians has taken advantage of training opportunities or have started practices in the European Union, having departed Poland permanently or temporarily, after the country joined the European Union in 2004...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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