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https://www.readbyqxmd.com/read/29220876/pharmacokinetics-clot-strength-and-safety-of-a-new-fibrinogen-concentrate-randomized-comparison-with-active-control-in-congenital-fibrinogen-deficiency
#1
C Ross, S Rangarajan, M Karimi, G H Toogeh, S Apte, T Lissitchkov, S Acharya, M J Manco-Johnson, A Srivastava, B Brand, B Schwartz, S Knaub, F Peyvandi
BACKGROUND: Human fibrinogen concentrate (HFC) corrects fibrinogen deficiency in congenital a-/hypofibrinogenaemia. OBJECTIVES: To assess pharmacokinetics (PK), effects on thromboelastometry maximum clot firmness (MCF), and safety of a new double virus-inactivated/eliminated, highly purified HFC vs. active control. PATIENTS/METHODS: In this multinational, randomized, phase II, open-label, crossover study in 22 congenital afibrinogenaemia patients ≥12 years, 70 mg kg-1 of new HFC (FIBRYGA, Octapharma AG) or control (Haemocomplettan® P/RiaSTAP™ , CSL Behring GmbH) were administered, followed by crossover to the other concentrate...
December 8, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29220861/do-we-need-plant-food-supplements-a-critical-examination-of-quality-safety-efficacy-and-necessity-for-a-new-regulatory-framework
#2
Mona Abdel-Tawab
Given the expanding market of plant food supplements (PFSs) not undergoing any pre-marketing authorization, the overall quality, safety and efficacy of PFSs were subjected to a critical examination. Although many high-quality PFSs exist on the legal market, quality concerns are in general justified. Besides economic adulteration, active ingredients dramatically differing from label claims and among products were reported in several studies. In addition, PFSs sold via the Internet may be intentionally adulterated with undeclared prescription drugs...
December 8, 2017: Planta Medica
https://www.readbyqxmd.com/read/29220585/-it-takes-a-man-to-put-me-on-the-bottom-gay-men-s-experiences-of-masculinity-and-anal-intercourse
#3
James P Ravenhill, Richard O de Visser
In anal intercourse between gay men, men who are typically insertive ("tops") are often perceived as, and may identify as, more masculine than those who are typically receptive ("bottoms"). "Versatile" men, who may adopt either position, may be perceived as more gender balanced and may transcend the gender-role stereotypes associated with self-labeling as top or bottom. The aim of this study was to explore how gay men's beliefs about masculinity were associated with their beliefs about the gendered nature of sexual self-labels and their behavior in anal intercourse...
December 8, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29220569/crocadepsins-depsipeptides-from-the-myxobacterium-chondromyces-crocatus-found-by-a-genome-mining-approach
#4
Frank Surup, Konrad Viehrig, Shwan Rachid, Alberto Plaza, Christine K Maurer, Rolf W Hartmann, Rolf Müller
Analysis of the genome sequence of the myxobacterium Chondromyces crocatus Cm c5 revealed the presence of numerous cryptic megasynthetase gene clusters, one of which we here assign to two previously unknown chlorinated metabolites by a comparative gene inactivation and secondary metabolomics approach. Structure elucidation of these compounds revealed a unique cyclic depsipeptide skeleton featuring β- and δ-amide bonds of aspartic acid and 3-methyl ornithine moieties, respectively. Insights into their biosynthesis were obtained by targeted gene inactivation and feeding experiments employing isotope-labeled precursors...
December 8, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29220536/cd36-deficiency-attenuates-immune-mediated-hepatitis-in-mice-by-modulating-the-proapoptotic-effects-of-cxcl10
#5
Che Xu, Chen Zhang, Jie Ji, Chao Wang, Jing Yang, Biao Geng, Ting Zhao, Hong Zhou, Xianmin Mu, Jinshun Pan, Shi Hu, Yuanfang Lv, Xingguo Chen, Hao Wen, Qiang You
The scavenger receptor, CD36, recognizes a diverse set of ligands, and has been implicated in a wide variety of normal and pathological processes, including lipid metabolism, angiogenesis, atherosclerosis, and phagocytosis. In particular, recent findings have demonstrated its crucial functions in sterile inflammation and tumor metastasis. However, the role of CD36 in immune-mediated hepatitis remains unclear. Concanavalin A (Con A)-induced liver injury is a well-established experimental T cell-mediated hepatitis...
December 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29220411/hexahydrocurcumin-protects-against-cerebral-ischemia-reperfusion-injury-attenuates-inflammation-and-improves-antioxidant-defenses-in-a-rat-stroke-model
#6
Piyawadee Wicha, Jiraporn Tocharus, Adchara Janyou, Jinatta Jittiwat, Chatchawan Changtam, Apichart Suksamrarn, Chainarong Tocharus
The purpose of the present experiment was to investigate whether hexahydrocurcumin (HHC) attenuates brain damage and improves functional outcome via the activation of antioxidative activities, anti-inflammation, and anti-apoptosis following cerebral ischemia/reperfusion (I/R). In this study, rats with cerebral I/R injury were induced by a transient middle cerebral artery occlusion (MCAO) for 2 h, followed by reperfusion. The male Wistar rats were randomly divided into five groups, including the sham-operated, vehicle-treated, 10 mg/kg HHC-treated, 20 mg/kg HHC-treated, and 40 mg/kg HHC-treated I/R groups...
2017: PloS One
https://www.readbyqxmd.com/read/29220399/-what-they-see-is-what-you-get-prescribing-antibiotics-for-respiratory-tract-infections-in-primary-care-do-high-prescribers-diagnose-differently-an-analysis-of-german-routine-data
#7
Susann Hueber, Thomas Kuehlein, Roman Gerlach, Martin Tauscher, Angela Schedlbauer
BACKGROUND: Characteristics of high and low prescribers of antibiotics in German primary care were analysed using population data. We aimed to evaluate differences in prescribing rates and factors being associated with high prescribing, and whether high prescribers made the diagnosis of perceived bacterial infections more often. METHODS: Routine data were provided by the Bavarian Association of Statutory Health Insurance Physicians. Routine data are delivered by primary care practices on a quarterly basis...
2017: PloS One
https://www.readbyqxmd.com/read/29220375/construction-and-validation-of-a-psychometric-scale-to-measure-awareness-on-consumption-of-irradiated-foods
#8
Tiago Rusin, Wilma Maria Coelho Araújo, Cristiane Faiad, Helio de Carvalho Vital
Although food irradiation has been used to ensure food safety, most consumers are unaware of the basic concepts of irradiation, misinterpreting information and demonstrating a negative attitude toward food items treated with ionizing radiation. This research is aimed at developing a tool to assess the awareness on the consumption of irradiated food. The sample was composed by employees from different social classes and school levels of Brazilian universities, who reflect the end-users of the irradiated foods, representative of the views of lay consumers...
2017: PloS One
https://www.readbyqxmd.com/read/29220339/to-flavor-or-not-to-flavor-extemporaneous-omeprazole-liquid
#9
Monica C Chuong, Catherine A Taglieri, Stephen G Kerr
Omeprazole is a proton pump inhibitor used to treat the symptoms of gastro esophageal reflux disease, ulcers, excess stomach acid, infection with Helicobacter pylori, and to control the gastric side effects of various drugs. The approved dosage forms in the U.S. are powder in compounding kits, delayed-release granules for oral suspension, oral delayed-release tablets, and oral delayed-release capsules. An extemporaneously compounded unsweetened oral liquid method, published in the International Journal of Pharmaceutical Compounding, was found to be commonly used by pharmacists...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29220315/background-modeling-by-stability-of-adaptive-features-in-complex-scenes
#10
Dan Yang, Chenqiu Zhao, Xiaohong Zhang, Sheng Huang
The single-feature-based background model often fails in complex scenes, since a pixel is better described by several features, which highlight different characteristics of it. Therefore, the multi-feature-based background model has drawn much attention recently. In this paper, we propose a novel multi-feature-based background model, named stability of adaptive feature (SoAF) model, which utilizes the stabilities of different features in a pixel to adaptively weigh the contributions of these features for foreground detection...
March 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29220314/random-access-memories-a-new-paradigm-for-target-detection-in-high-resolution-aerial-remote-sensing-images
#11
Zhengxia Zou, Zhenwei Shi
We propose a new paradigm for target detection in high resolution aerial remote sensing images under small target priors. Previous remote sensing target detection methods frame the detection as learning of detection model + inference of class-label and bounding-box coordinates. Instead, we formulate it from a Bayesian view that at inference stage, the detection model is adaptively updated to maximize its posterior that is determined by both training and observation. We call this paradigm "random access memories (RAM)...
March 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29218525/translocation-and-redistribution-of-glut4-using-a-dual-labeled-reporter-assay
#12
Robert M Jackson, Ann Louise Olson
It is crucial to determine the regulation of GLUT4 translocation and redistribution to the plasma membrane. The HA-GLUT4-GFP dual-reporter construct has become an important tool in the assessment of GLUT4 recycling in cultured adipocytes and myocytes. Through the use of light microscopy, this reporter construct allows for visualization of GLUT4 specifically at the cell surface or GLUT4 that has recycled from the cell surface while simultaneously marking the total GLUT4 pool. Here, we discuss and outline the general application of this reporter construct and its use in evaluating GLUT4 translocation within cultured adipocytes...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29218501/evaluating-safety-reporting-in-paediatric-antibiotic-trials-2000-2016-a-systematic-review-and-meta-analysis
#13
REVIEW
Paola Pansa, Yingfen Hsia, Julia Bielicki, Irja Lutsar, A Sarah Walker, Mike Sharland, Laura Folgori
BACKGROUND: There are very few options to treat multidrug-resistant bacterial infections in children. A major barrier is the duration and complexity of regulatory trials of new antibiotics. Extrapolation of safety data from adult trials could facilitate drug development for children. OBJECTIVE: We performed a systematic review on the safety of antibiotic clinical trials (CTs) in children (0-18 years) to evaluate the overall quality of safety trials conducted in children and to determine if age-specific adverse events (AEs) could be identified for specific antibiotic classes...
December 7, 2017: Drugs
https://www.readbyqxmd.com/read/29218486/interaction-study-between-hcv-ns5a-d2-and-ns5b-using-19f-nmr
#14
Marie Dujardin, François-Xavier Cantrelle, Guy Lippens, Xavier Hanoulle
The non structural protein 5A (NS5A) regulates the replication of the hepatitis C viral RNA through a direct molecular interaction of its domain 2 (NS5A-D2) with the RNA dependent RNA polymerase NS5B. Because of conflicting data in the literature, we study here this molecular interaction using fluorinated versions of the NS5A-D2 protein derived from the JFH1 Hepatitis C Virus strain. Two methods to prepare fluorine-labelled NS5A-D2 involving the biosynthetic incorporation of a 19F-tryptophan using 5-fluoroindole and the posttranslational introduction of fluorine by chemical conjugation of 2-iodo-N-(trifluoromethyl)acetamide with the NS5A-D2 cysteine side chains are presented...
December 7, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29218472/correction-to-quantifying-and-understanding-carbon-storage-and-sequestration-within-the-eastern-arc-mountains-of-tanzania-a-tropical-biodiversity-hotspot
#15
Simon Willcock, Oliver L Phillips, Philip J Platts, Andrew Balmford, Neil D Burgess, Jon C Lovett, Antje Ahrends, Julian Bayliss, Nike Doggart, Kathryn Doody, Eibleis Fanning, Jonathan M H Green, Jaclyn Hall, Kim L Howell, Rob Marchant, Andrew R Marshall, Boniface Mbilinyi, Pantaleon K T Munishi, Nisha Owen, Ruth D Swetnam, Elmer J Topp-Jorgensen, Simon L Lewis
Upon publication of the original article [1], the authors noticed that the figure labelling for Fig. 4 in the online version was processed wrong. The top left panel should be panel a, with the panels to its right being b and c. d and e should be the panels on the lower row, and f is correct. The graphs themselves are all correct. It is simply the letter labels that are wrong.
December 7, 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/29218370/differentiation-of-residual-recurrent-gliomas-from-postradiation-necrosis-with-arterial-spin-labeling-and-diffusion-tensor-magnetic-resonance-imaging-derived-metrics
#16
Ahmed Abdel Khalek Abdel Razek, Lamiaa El-Serougy, Mohamed Abdelsalam, Gada Gaballa, Mona Talaat
PURPOSE: The aim of this study is to differentiate recurrent/residual gliomas from postradiation changes using arterial spin labeling (ASL) perfusion and diffusion tensor imaging (DTI)-derived metrics. METHODS: Prospective study was conducted upon 42 patients with high-grade gliomas after radiotherapy only or prior to other therapies that underwent routine MR imaging, ASL, and DTI. The tumor blood flow (TBF), fractional anisotropy (FA), and mean diffusivity (MD) of the enhanced lesion and related edema were calculated...
December 7, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29218332/evaluating-author-and-user-experience-for-an-audio-haptic-system-for-annotation-of-physical-models
#17
James M Coughlan, Joshua Miele
We describe three usability studies involving a prototype system for creation and haptic exploration of labeled locations on 3D objects. The system uses a computer, webcam, and fiducial markers to associate a physical 3D object in the camera's view with a predefined digital map of labeled locations ("hotspots"), and to do real-time finger tracking, allowing a blind or visually impaired user to explore the object and hear individual labels spoken as each hotspot is touched. This paper describes: (a) a formative study with blind users exploring pre-annotated objects to assess system usability and accuracy; (b) a focus group of blind participants who used the system and, through structured and unstructured discussion, provided feedback on its practicality, possible applications, and real-world potential; and (c) a formative study in which a sighted adult used the system to add labels to on-screen images of objects, demonstrating the practicality of remote annotation of 3D models...
October 2017: ASSETS Association for Computing Machinery
https://www.readbyqxmd.com/read/29218012/anti-tumor-effect-of-rhaponticum-uniflorum-ethyl-acetate-extract-by-regulation-of-peroxiredoxin1-and-epithelial-to-mesenchymal-transition-in-oral-cancer
#18
Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang
Objective: To explore whether Rhaponticum uniflorum (R. uniflorum) had anti-tumor effects in oral cancer and investigate the molecular mechanisms involved in these anti-tumor effects. Methods: Chemical compositions of R. uniflorum ethyl acetate (RUEA) extracts were detected by ultra-performance liquid chromatography-Q/time-of-flight mass spectrometry (UPLC-Q/TOF-MS), followed by pharmacology-based network prediction analysis. The effects of RUEA extracts on proliferation, apoptosis, migration, and invasion ability of human oral squamous cell carcinoma (OSCC) cell line SCC15 were evaluated by CCK8 assay, Annexin V- fluorescein isothiocyanate/propidium iodide staining, wound healing assay, and Matrigel invasion assay, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29218001/upregulation-of-cdh1-attenuates-isoflurane-induced-neuronal-apoptosis-and-long-term-cognitive-impairments-in-developing-rats
#19
Xuan Li, Kai Wei, Rong Hu, Bo Zhang, Li Li, Li Wan, Chuanhan Zhang, Wenlong Yao
Neonatal exposure to isoflurane can result in neuroapoptosis and persistent cognitive impairments. However, the underlying mechanisms remain elusive. Anaphase-promoting complex/cyclosome (APC/C) and its co-activator Cdh1 are E3 ubiquitin ligases that play important roles in the central nervous system, including in the regulation of neuronal survival, synaptic development, and mammalian learning and memory. However, whether APC/C-Cdh1 is involved in isoflurane-induced neurotoxicity in developing rats remains unclear...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29217752/mapping-the-distribution-of-stem-progenitor-cells-across-the-middle-ear-during-homeostasis-and-inflammation
#20
Abigail S Tucker, Carlene J Dyer, Juan M Fons Romero, Tathyane H N Teshima, Jennifer C Fuchs, Hannah Thompson
The middle ear epithelium is derived from neural crest and endoderm, which line distinct regions of the middle ear cavity. Here we investigate the distribution of putative stem cell markers in the middle ear combined with an analysis of the location of label retaining cells (LRCs) to create a map of the middle ear mucosa. We show that proliferating cells and LRCs were associated with specific regions of the ear epithelium, concentrated in the hypotympanum at the base of the auditory bulla and around the ear drum...
December 7, 2017: Development
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