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https://www.readbyqxmd.com/read/28095899/what-is-the-relationship-between-type-2-diabetes-mellitus-status-and-the-neuroradiological-correlates-of-cerebral-small-vessel-disease-in-adults-protocol-for-a-systematic-review
#1
Clark Funnell, Mary M Doyle-Waters, Samuel Yip, Thalia Field
BACKGROUND: Cerebral small vessel disease (CSVD) is a common cause of stroke, dementia, and functional decline. In recent years, neuroradiologic correlates of CSVD have been identified. These imaging findings, best characterized on magnetic resonance imaging (MRI), include some combination of white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, and cerebral atrophy. Though some cohorts have reported that participants with type 2 diabetes mellitus (T2DM), an important risk factor for CSVD, may have a distinct neuroradiologic phenotype, this relationship is not well-characterized...
January 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28089561/characterizing-deep-white-matter-hyperintensities-in-patients-with-symptomatic-isolated-cortical-superficial-siderosis
#2
Dimitri Renard, Lavinia Tatu, Christophe Demattei, Christophe Hirtz, Sylvain Lehmann, Eric Thouvenot
BACKGROUND: In patient with cerebral amyloid angiopathy (CAA) presenting with lobar hemorrhage (LH), magnetic resonance imaging (MRI) white matter hyperintensities (WMH) tend to be predominant in posterior regions with the "multiple subcortical spots" WMH pattern as the most frequent topographical WMH pattern. Our aim was to analyze WMH severity and topographical distribution in patients with cortical superficial siderosis (CSS). METHODS: We retrospectively analyzed MRIs from consecutive symptomatic isolated (i...
January 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28089254/volumetric-analysis-of-carotid-plaque-components-and-cerebral-microbleeds-a-correlative-study
#3
Luca Saba, Roberto Sanfilippo, Michele di Martino, Michele Porcu, Roberto Montisci, Pierleone Lucatelli, Michele Anzidei, Marco Francone, Jasjit S Suri
PURPOSE: The purpose of this work was to explore the association between carotid plaque volume (total and the subcomponents) and cerebral microbleeds (CMBs). MATERIALS AND METHODS: Seventy-two consecutive (male 53; median age 64) patients were retrospectively analyzed. Carotid arteries were studied by using a 16-detector-row computed tomography scanner whereas brain was explored with a 1.5 Tesla system. CMBs were studied using a T2*-weighted gradient-recalled echo sequence...
January 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28088807/posterior-versus-anterior-circulation-stroke-in-young-adults-a-comparative-study-of-stroke-aetiologies-and-risk-factors-in-stroke-among-young-fabry-patients-sifap1
#4
Bettina von Sarnowski, Ulf Schminke, Ulrike Grittner, Christian Tanislav, Tobias Böttcher, Michael G Hennerici, Turgut Tatlisumak, Jukka Putaala, Manfred Kaps, Franz Fazekas, Christian Enzinger, Arndt Rolfs, Christof Kessler
BACKGROUND: Although 20-30% of all strokes occur in the posterior circulation, few studies have explored the characteristics of patients with strokes in the posterior compared to the anterior circulation so far. Especially data on young patients is missing. METHODS: In this secondary analysis of data of the prospective multi-centre European sifap1 study that investigated stroke and transient ischemic attack (TIA) patients aged 18-55 years, we compared vascular risk factors, stroke aetiology, presence of white matter hyperintensities (WMH) and cerebral microbleeds (CMB) between patients with ischaemic posterior circulation stroke (PCS) and those having suffered from anterior circulation stroke (ACS) based on cerebral MRI...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28088798/the-intracranial-b2leed3s-score-and-the-risk-of-intracranial-hemorrhage-in-ischemic-stroke-patients-under-antiplatelet-treatment
#5
Pierre Amarenco, Leila Sissani, Julien Labreuche, Eric Vicaut, Marie Germaine Bousser, Angel Chamorro, Marc Fisher, Ian Ford, Kim M Fox, Michael G Hennerici, Heinrich Mattle, Peter M Rothwell, Philippe Gabriel Steg, Hans-Christoph Diener, Ralph L Sacco, Jacoba P Greving, Ale Algra
BACKGROUND: Chronic antiplatelet therapy in the post-acute phase of non-cardioembolic ischemic stroke is limited by the risk of intracranial hemorrhage (ICH) complications. METHODS: We developed an ICH risk score based on the PERFORM trial cohort (n = 19,100), which included patients with a non-cardioembolic ischemic stroke or transient ischemic attack, and externally validated this score in one contemporary trial of very similar size and inclusion criteria, the PRoFESS trial (n = 20,332 patients)...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28065404/cerebral-microbleeds-and-risk-of-intracerebral-hemorrhage-post-intravenous-thrombolysis
#6
Ramin Zand, Georgios Tsivgoulis, Mantinderpreet Singh, Michael McCormack, Nitin Goyal, Muhammad Fawad Ishfaq, Reza Bavarsad Shahripour, Katherine Nearing, Lucas Elijovich, Anne W Alexandrov, David S Liebeskind, Andrei V Alexandrov
BACKGROUND: Stroke patients who have cerebral micro bleeds (CMBs) could be potentially at a greater risk for symptomatic intracerebral hemorrhage (sICH) than those patients without CMBs. The aim of our study was to investigate whether the presence and burden of CMBs are associated with post IVT sICH. METHODS: In this multicenter study, consecutive patients treated with intravenous tissue plasminogen activator were prospectively identified and analyzed. Patients without magnetic resonance imaging (MRI) within 24 hours of treatment were excluded...
January 3, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28062861/incidence-locations-and-longitudinal-course-of-cerebral-microbleeds-in-european-moyamoya
#7
Holger Wenz, Ralf Wenz, Máté Maros, Gregory Ehrlich, Mansour Al-Zghloul, Christoph Groden, Alex Förster
BACKGROUND AND PURPOSE: Cerebral microbleeds (cMBs) have previously been linked with especially high incidence in Asian patients with moyamoya together with high tendency to bleed. This, presumably, is characteristic of patients with moyamoya. Herein, we, therefore, investigate retrospectively the frequency, location, and longitudinal course of cMBs in a large German cohort. METHODS: We included all patients with moyamoya who underwent standard magnetic resonance imaging, including T2*-weighted images, in our department between 1998 and 2015...
January 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28051884/the-risk-factors-and-pattern-of-cerebral-microbleeds-in-parkinson-s-disease
#8
Dian He, Chun-Feng Liu, Lan Chu, Ya Li, Da-Fei Xu, Ling Jiao
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMBs) in Parkinson's disease (PD) have been reported recently and concerned increasingly. Our aim was to investigate the risk factors and pattern of CMBs in patients with PD, as well as the influence of risk factors on the pattern of CMBs. METHODS: We retrospectively collected medical and imaging data of 247 patients who underwent brain susceptibility-weighted imaging (SWI). Logistic regression analyses were performed to determine the risk factors of CMBs...
January 4, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28042517/rust-on-the-brain-from-microbleeds-and-its-relevance-to-alzheimer-studies-invited-commentary-on-cacciottolo-neurobiology-of-aging-2016
#9
M Cacciottolo, T E Morgan, C E Finch
Cerebral microbleeds (MB) and small vessel disease (SVD) with congophilic arterial angiopathy (CAA) are increasingly recognized as a variable factor in AD cognitive impairments. This commentary on our recent report on sex-ApoE interactions in MBs published this February, briefly explores three aspects of MBs that could not be fully discussed therein: I, A possible gap between the prevalence of MBs as detected by MRI and post mortem analysis; II, The role of hemoglobin-degradation products in amyloid-attributed neurodegenerative changes; and III, Possible assessment of MB by cerebrospinal fluid (CSF) assays for iron-related markers to better screen patient subgroups for AD interventions...
November 2016: Journal of Alzheimer's Disease and Parkinsonism
https://www.readbyqxmd.com/read/28018214/total-cerebral-small-vessel-disease-mri-score-is-associated-with-cognitive-decline-in-executive-function-in-patients-with-hypertension
#10
Renske Uiterwijk, Robert J van Oostenbrugge, Marjolein Huijts, Peter W De Leeuw, Abraham A Kroon, Julie Staals
Objectives: Hypertension is a major risk factor for white matter hyperintensities (WMH), lacunes, cerebral microbleeds, and perivascular spaces, which are MRI markers of cerebral small vessel disease (SVD). Studies have shown associations between these individual MRI markers and cognitive functioning and decline. Recently, a "total SVD score" was proposed in which the different MRI markers were combined into one measure of SVD, to capture total SVD-related brain damage. We investigated if this SVD score was associated with cognitive decline over 4 years in patients with hypertension...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28011882/mycophenolate-mofetil-prevents-cerebrovascular-injury-in-stroke-prone-spontaneously-hypertensive-rats
#11
Isha Dhande, Yaming Zhu, Michael C Braun, M John Hicks, Scott E Wenderfer, Peter A Doris
BACKGROUND AND PURPOSE: Stroke-prone spontaneously hypertensive rats (SHR-A3) develop strokes and progressive kidney disease as a result of naturally occurring genetic variations. We recently identified genetic variants in immune signaling pathways that contribute to end-organ injury. The present study was designed to test the hypothesis that a dysregulated immune response promotes stroke susceptibility. METHODS: 20-week old male SHR-A3 rats were salt loaded and treated with the immunosuppressant mycophenolate mofetil (MMF, 25 mg/kg/day, p...
December 23, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/28000005/comparison-of-cerebrospinal-fluid-profiles-in-alzheimer-s-disease-with-multiple-cerebral-microbleeds-and-cerebral-amyloid-angiopathy-related-inflammation
#12
Akio Kimura, Masao Takemura, Kuniaki Saito, Nobuaki Yoshikura, Yuichi Hayashi, Naoko Harada, Hiroshi Nishida, Hideto Nakajima, Takashi Inuzuka
Brain magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) sometimes reveals multiple cerebral microbleeds (CMBs) and confluent white matter hyperintensities (WMHs) similar to those observed in cerebral amyloid angiopathy-related inflammation (CAA-I). To determine whether there might be common pathophysiological mechanisms underlying the MRI findings of multiple CMBs and confluent WMHs, we investigated the cerebrospinal fluid (CSF) profiles of 38 AD, five amnestic mild cognitive impairment (MCI), and six CAA-I patients...
December 20, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27999110/subclinical-disease-burden-as-assessed-by-whole-body-mri-in-subjects-with-prediabetes-subjects-with-diabetes-and-normal-control-subjects-from-the-general-population-the-kora-mri-study
#13
Fabian Bamberg, Holger Hetterich, Susanne Rospleszcz, Roberto Lorbeer, Sigrid D Auweter, Christopher L Schlett, Anina Schafnitzel, Christian Bayerl, Andreas Schindler, Tobias Saam, Katharina Müller-Peltzer, Wieland Sommer, Tanja Zitzelsberger, Jürgen Machann, Michael Ingrisch, Sonja Selder, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Christian Weber, Birgit Ertl-Wagner, Steffen Massberg, Maximilian F Reiser, Annette Peters
Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density fat fraction [PDFF] and subcutaneous and visceral abdominal fat)...
January 2017: Diabetes
https://www.readbyqxmd.com/read/27994360/the-clinical-significance-of-brain-microbleeds-in-patients-with-alzheimer-s-disease-preliminary-study
#14
Jae-Hyeok Heo, Dong-Gyu Im, Seung-Hyeon Lee, Jin-Young Ahn
BACKGROUND: Microbleeds (MBs) are observed frequently in Alzheimer's disease (AD) and suggested to play a crucial role in the pathophysiology, but their clinical significance remains unclear. MATERIALS AND METHODS: The study recruited 100 patients with AD who were diagnosed at the memory clinic in Seoul Medical Center in 2014. For each patient, baseline characteristics, neuropsychological tests, cerebrovascular risk factors, medial temporal lobe atrophy (MTLA), and severity of small vessel disease (SVD) according to the existence of MBs were evaluated...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27994355/interaction-of-incidental-microbleeds-and-prior-use-of-antithrombotics-with-early-hemorrhagic-transformation-causative-or-protective
#15
Konark Malhotra, Monica Khunger, Bichun Ouyang, David S Liebeskind, Yousef M Mohammad
BACKGROUND: Gradient echo (GRE) sequence of magnetic resonance imaging (MRI) is a sensitive tool to detect hemorrhagic transformation (HT) and old cerebral microbleeds (CMBs). Presence of CMBs and prior use of antithrombotics pose a risk of HT in ischemic stroke. We evaluated the association of CMBs and antithrombotic use with resultant HT in acute ischemic stroke (AIS). METHODS: This retrospective study included AIS patients admitted to our center between January 2009 and August 2010 who underwent GRE-weighted MRI within 48 h of admission...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27980126/prevention-of-stroke-in-patients-with-silent-cerebrovascular-disease-a-scientific-statement-for-healthcare-professionals-from-the-american-heart-association-american-stroke-association
#16
Eric E Smith, Gustavo Saposnik, Geert Jan Biessels, Fergus N Doubal, Myriam Fornage, Philip B Gorelick, Steven M Greenberg, Randall T Higashida, Scott E Kasner, Sudha Seshadri
Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. It is the most common incidental finding on brain scans. To summarize evidence on the diagnosis and management of silent cerebrovascular disease to prevent stroke, the Stroke Council of the American Heart Association convened a writing committee to evaluate existing evidence, to discuss clinical considerations, and to offer suggestions for future research on stroke prevention in patients with 3 cardinal manifestations of silent cerebrovascular disease: silent brain infarcts, magnetic resonance imaging white matter hyperintensities of presumed vascular origin, and cerebral microbleeds...
December 15, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27956564/n-terminal-pro-brain-natriuretic-peptide-and-subclinical-brain-small-vessel-disease
#17
Andrea Vilar-Bergua, Iolanda Riba-Llena, Anna Penalba, Luz María Cruz, Joan Jiménez-Balado, Joan Montaner, Pilar Delgado
OBJECTIVE: To study the association of N-terminal pro-brain natriuretic peptide (NT-proBNP) with several brain MRI markers of brain vascular disease in a sample of participants free of stroke and dementia. METHODS: NT-proBNP plasma level was determined by means of a sandwich immunoassay method in a cohort study comprising 278 hypertensive patients. The presence of silent brain infarcts, brain microbleeds, enlarged perivascular spaces, and white matter hyperintensity volumes was assessed by brain MRI...
December 13, 2016: Neurology
https://www.readbyqxmd.com/read/27938433/deep-microbleeds-and-periventricular-white-matter-disintegrity-are-independent-predictors-of-attention-executive-dysfunction-in-non-dementia-patients-with-small-vessel-disease
#18
Wen-Wei Cao, Yao Wang, Quan Dong, Xue Chen, Yan-Sheng Li, Yan Zhou, Li Gao, Ye Deng, Qun Xu
BACKGROUND: Cerebral small vessel disease (SVD) is the common cause of cognitive decline in the old population. MRI can be used to clarify its mechanisms. However, the surrogate markers of MRI for early cognitive impairment in SVD remain uncertain to date. We investigated the cognitive impacts of cerebral microbleeds (CMBs), diffusion tensor imaging (DTI), and brain volumetric measurements in a cohort of post-stroke non-dementia SVD patients. METHODS: Fifty five non-dementia SVD patients were consecutively recruited and categorized into two groups as no cognitive impairment (NCI) (n = 23) or vascular mild cognitive impairment (VaMCI) (n = 32)...
December 12, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27936213/radiologic-histopathologic-correlation-of-cerebral-microbleeds-using-pre-mortem-and-post-mortem-mri
#19
Sven Haller, Marie-Louise Montandon, François Lazeyras, Max Scheffler, Stephan Meckel, Francois R Herrmann, Panteleimon Giannakopoulos, Enikö Kövari
INTRODUCTION: Cerebral microbleeds (CMB), also known as cerebral microhemorrhages, are small areas of susceptibility on brain magnetic resonance imaging (MRI), that are increasingly detected due to the higher availability of high-field MRI systems and dedicated pulse sequences. The prevalence of CMBs increases in cases with cognitive decline. The current investigation assessed the poorly investigated radiologic-histopathologic correlation of CMBs on MRI. METHODS: The local ethical committee approved the current investigation...
2016: PloS One
https://www.readbyqxmd.com/read/27934941/oral-cnm-positive-streptococcus-mutans-expressing-collagen-binding-activity-is-a-risk-factor-for-cerebral-microbleeds-and-cognitive-impairment
#20
Isao Watanabe, Nagato Kuriyama, Fumitaro Miyatani, Ryota Nomura, Shuhei Naka, Kazuhiko Nakano, Masafumi Ihara, Komei Iwai, Daisuke Matsui, Etsuko Ozaki, Teruhide Koyama, Masaru Nishigaki, Toshiro Yamamoto, Aiko Tamura, Toshiki Mizuno, Kentaro Akazawa, Akihiro Takada, Kazuo Takeda, Kei Yamada, Masanori Nakagawa, Tokutaro Tanaka, Narisato Kanamura, Robert P Friedland, Yoshiyuki Watanabe
Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated...
December 9, 2016: Scientific Reports
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