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Nevi melanocytic congenital

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https://www.readbyqxmd.com/read/29138054/keratinocyte-sonic-hedgehog-up-regulation-drives-the-development-of-giant-congenital-nevi-via-paracrine-endothelin-1-secretion
#1
Arash Chitsazan, Blake Ferguson, Rehan Villani, Herlina Y Handoko, Pamela Mukhopadhyay, Brian Gabrielli, Wolter J Mooi, H Peter Soyer, Duncan Lambie, Kiarash Khosrotehrani, Grant Morahan, Graeme J Walker
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishment the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29091921/melanin-pigments-in-the-melanocytic-nevus-regress-spontaneously-after-inactivation-by-high-hydrostatic-pressure
#2
Michiharu Sakamoto, Naoki Morimoto, Chizuru Jinno, Atsushi Mahara, Shuichi Ogino, Shigehiko Suzuki, Kenji Kusumoto, Tetsuji Yamaoka
We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later...
2017: PloS One
https://www.readbyqxmd.com/read/29077988/laser-treatment-of-congenital-melanocytic-nevi-a-systematic-review
#3
REVIEW
C A M Eggen, J E Lommerts, E J van Zuuren, J Limpens, S G M A Pasmans, A Wolkerstorfer
Recent studies on congenital melanocytic nevi (CMN) indicate a lower risk for melanoma than assumed for many years. As a result, the treatment paradigm in CMN shifted from complete removal to cosmetically acceptable, less invasive treatment options such as laser treatment. Our objective was to systematically review the efficacy and safety of laser therapy for CMN. We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and PubMed. We rated the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach...
October 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29077579/acquisition-of-somatic-nras-mutations-in-central-nervous-system-melanocytes-a-predisposing-risk-factor-to-primary-melanoma-of-the-central-nervous-system-a-frequently-forgotten-pitfall-in-congenital-nevi
#4
Maria C Garrido, Lidia Maroñas-Jiménez, Carlos Morales-Raya, Yolanda Ruano, Jose L Rodriguez-Peralto
Congenital melanocytic nevi (CMN) are benign melanocytic proliferations that are usually present at birth. A somatic mosaicism for an NRAS point mutation is responsible for the several phenotypic abnormalities that may be associated with congenital nevi. We report the case of a 7-year-old boy with a proliferative nodule (PN) arising in a Giant CMN completely excised and with several visceral and intraspinal melanoma metastases with no evidence of primary cutaneous melanoma. The careful analysis of the clinical, morphologic, and molecular features allowed the distinction of between the benign PN (BPN) and the melanoma...
October 17, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29076319/serial-tissue-expansion-at-the-same-site-in-pediatric-patients-is-the-subsequent-expansion-faster
#5
Moon Ki Lee, Seong Oh Park, Tae Hyun Choi
Background: Serial tissue expansion is performed to remove giant congenital melanocytic nevi. However, there have been no studies comparing the expansion rate between the subsequent and preceding expansions. In this study, we analyzed the rate of expansion in accordance with the number of surgeries, expander location, expander size, and sex. Methods: A retrospective analysis was performed in pediatric patients who underwent tissue expansion for giant congenital melanocytic nevi...
October 26, 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28942405/congenital-melanocytic-nevus-mimicking-a-turban-tumour-in-an-18-year-old-filipino-male
#6
Maria Elinor Grace Sison, Eileen Cubillan, Bernard U Tansipek
Congenital melanocytic nevi (CMN) are nevi that are present at birth or arise within the first few weeks of life. They are often found on the trunk, head and neck and extremities. We report herein an unusual presentation of a CMN as a cerebriform tumour presenting as secondary cutis verticis gyrata on the scalp of an 18-year-old Filipino male.
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28676327/anatomic-mapping-and-clinicopathologic-analysis-of-benign-acral-melanocytic-neoplasms-a-comparison-between-adults-and-children
#7
COMPARATIVE STUDY
Na Hee Kim, Yoo Duk Choi, Hyun Ju Seon, Jee-Bum Lee, Sook Jung Yun
BACKGROUND: The clinicopathologic features of benign acral melanocytic neoplasms (BAMNs) remain poorly understood. OBJECTIVE: To define the clinicopathologic features of BAMNs. METHODS: We analyzed clinical data and mapped BAMNs anatomically. We also reviewed the histopathologic features of BAMNs and compared these between adults and children. RESULTS: We included 396 cases of BAMN: 335 adults and 61 children (376 acquired and 20 congenital lesions)...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28538892/giant-congenital-melanocytic-nevi-40-years-of-experience-with-the-serial-excision-technique
#8
Lais de Abreu Mutti, Marta Regina Machado Mascarenhas, João Marcos Goes de Paiva, Ronaldo Golcman, Mauro Yoshiaki Enokihara, Benjamin Golcman
Although giant congenital melanocytic nevus is a rare lesion, it causes significant deformity and carries a risk of malignant degeneration. Different surgical techniques for the lesion removal are described, including serial resection, resection with skin grafting, and resection and coverage with expanded skin flap (skin expanders). The aim of this study is to report the author's 40 years of experience with cases requiring at least 4 serial excisions to complete the treatment. Serial resection is an effective, safe, and simple technique that requires a lot of patience...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538885/proliferative-nodule-in-melanocytic-nevi-mimicking-deep-penetrating-nevus
#9
Ana Almodovar-Real, Alejandro Molina-Leyva, Jose Aneiros-Fernandez, Miguel Antonio Diaz-Martinez
Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with features of deep penetrating nevus.
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538879/a-prospective-study-of-patients-with-large-congenital-melanocytic-nevi-and-the-risk-of-melanoma
#10
Ana Carolina Leite Viana, Eugênio Marcos Andrade Goulart, Bernardo Gontijo, Flávia Vasques Bittencourt
Background: Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial. Objective: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America. Methods: Our prospective cohort included only patients with congenital nevi ≥20cm...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28508099/giant-congenital-melanocytic-nevi-and-malignant-transformation-a-case-for-early-radical-intervention
#11
Christopher R Maguire, Ryan Livingston, Gael E Phillips, Roy M Kimble
The purpose of this paper is to highlight the risk of early malignant transformation in infants with giant congenital melanocytic nevi (GN) and demonstrate the potential for earlier intervention with aggressive surgery. We describe the case of a child born with a GN who developed a metastatic melanoma early in life, despite early commencement of resection of the nevus. This is contrasted against a second case of a child in which a more radical management was conducted. Despite early commencement of serial resection of the GN, the first child in this series died of metastatic melanoma prior to complete excision of the nevus...
July 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28449284/paediatric-melanoma
#12
REVIEW
C Stefanaki, L Chardalias, E Soura, A Katsarou, A Stratigos
Paediatric melanoma, although rare, is the most common skin cancer in children. Our current knowledge on paediatric melanoma incidence trends is expanding, as several studies have addressed this issue with conflicting results. Known risk factors for paediatric melanoma include family history of melanoma, a previous history of malignancy, large congenital nevi, numerous melanocytic nevi, sunburns, increased UV exposure and a sun-sensitive phenotype. In younger children, melanoma more often presents with atypical features, such as a changing, amelanotic or uniformly coloured, often bleeding lesion, not fulfilling in most cases the conventional ABCDE criteria...
October 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28353563/tissue-expansion-in-the-treatment-of-giant-congenital-melanocytic-nevi-of-the-upper-extremity
#13
Tengxiao Ma, Ke Fan, Lei Li, Feng Xie, Hao Li, Haiyan Chou, Zhengwen Zhang
The aim of our study was to use tissue expansion for the treatment of giant congenital melanocytic nevi of the upper extremity and examine potential advantages over traditional techniques.There were 3 stages in the treatment of giant congenital melanocytic nevi of the upper extremities using tissue expansion: first, the expander was inserted into the subcutaneous pocket; second, the expander was removed, lesions were excised, and the wound of the upper extremity was placed into the pocket to delay healing; third, the residual lesion was excised and the pedicle was removed...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28329507/giant-benign-intradermal-melanocytic-nevus-of-rapid-onset
#14
LETTER
Sarah J Coates, Andrew Avarbock, Garrett T Desman
Benign melanocytic nevi are slowly growing acquiredor congenital tumors with varied morphology,commonly encountered in dermatology clinics. Anytumor with rapid clinical growth must be assessedcarefully in order to exclude malignancy. We report awoman with a histopathologically benign intradermalnevus that presented as a rapidly evolving largecutaneous mass on the ear. Owing to the discrepancybetween the clinical and histopathological findings,an extensive histopathological work-up involvingmany deeper sections, immunohistochemical stains,and fluorescent in situ hybridization (FISH) analysiswas conducted in order to rule out malignancy...
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28325390/patterns-of-distribution-of-giant-congenital-melanocytic-nevi-gcmn-the-6b-rule
#15
Vanessa P Martins da Silva, Ashfaq Marghoob, Ramon Pigem, Cristina Carrera, Paula Aguilera, Joan A Puig-Butillé, Susana Puig, Josep Malvehy
BACKGROUND: Garment-related terms have been used to describe the pattern of distribution of giant congenital melanocytic nevi (GCMN). OBJECTIVE: We sought to describe patterns of distribution of GCMN and propose a classification scheme. METHODS: Photographic records of patients with GCMN from the Hospital Clinic of Barcelona were analyzed and a classification based on observed GCMN distribution patterns was created. The classification was independently applied by 8 observers to cases found in the literature...
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28296519/congenital-melanocytic-nevus-on-the-lower-eyelid-treated-with-continuous-wave-and-superpulsed-co2-laser-followed-by-erbium-laser
#16
Vito Abrusci, Valentina Benzecry
There are several therapeutic options to treat congenital melanocytic nevi. The motivations for the treatment of small- to medium-sized congenital nevi located on the face or other sensitive areas are frequently cosmetic. The choice of therapy depends on the operator's expertise and on the likelihood of improved cosmesis. We report a case of a medium-sized congenital nevi located on the lower eyelid, successfully treated with a combination of ablative lasers with a single surgical procedure. We achieved an excellent clinical and cosmetic result...
August 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28290622/melanoma-and-melanocytic-nevi-in-paediatric-patients-a-single-institution-experience
#17
Paola Sgubbi, Francesco Savoia, Emi Dika, Iria Neri, Pier A Fanti, Annalisa Patrizi
BACKGROUND: Melanoma is an infrequent neoplasm in children and adolescents. The number of consultancies for melanocytic nevi control in the paediatric population is increased by the major anxiety of parents and paediatricians. METHODS: A retrospective chart review was performed in order to evaluate the incidence rate of melanoma, Spitz nevi, congenital and acquired melanocytic nevi in patients aged 14 years or less and referred to our institution from April 2010 to September 2015...
March 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28248717/mass-spectrometry-imaging-can-distinguish-on-a-proteomic-level-between-proliferative-nodules-within-a-benign-congenital-nevus-and-malignant-melanoma
#18
Rossitza Lazova, Zhe Yang, Constantin El Habr, Young Lim, Keith Adam Choate, Erin H Seeley, Richard M Caprioli, Li Yangqun
Histopathological interpretation of proliferative nodules occurring in association with congenital melanocytic nevi can be very challenging due to their similarities with congenital malignant melanoma and malignant melanoma arising in association with congenital nevi. We hereby report a diagnostically challenging case of congenital melanocytic nevus with proliferative nodules and ulcerations, which was originally misdiagnosed as congenital malignant melanoma. Subsequent histopathological examination in consultation by one of the authors (R...
September 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28242090/congenital-melanocytic-nevi-in-young-children-histopathologic-features-and-clinical-outcomes
#19
Emily A Simons, Jennifer T Huang, Birgitta Schmidt
BACKGROUND: Although only large congenital melanocytic nevi (CMN) are associated with a significantly high risk for malignant transformation, CMN of all sizes are prone to changes in clinical appearance in early childhood and thus are often biopsied or excised. While CMNs typically exhibit benign behavior, atypical histopathologic findings might be common and may prompt additional unnecessary procedures. OBJECTIVE: To assess the prevalence and associated clinical outcomes of atypical histopathologic features in CMN in children...
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28223745/intense-pulsed-light-alone-and-in-combination-with-erbium-yttrium-aluminum-garnet-laser-on-small-to-medium-sized-congenital-melanocytic-nevi-single-center-experience-based-on-retrospective-chart-review
#20
Mi So Lee, Hee Jin Jun, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
BACKGROUND: Treatment of congenital melanocytic nevi (CMN) with intense pulsed light (IPL) has recently produced promising results. OBJECTIVE: To evaluate the clinical and histological outcomes of small-to-medium sized CMN treated with IPL alone and in combination with erbium: yttrium-aluminum-garnet (Er: YAG) laser. METHODS: We performed a retrospective chart review of 26 small-to-medium sized CMN treated as described above. The reduction in visible pigmentation, signs of recurrence and any adverse skin changes were evaluated by two independent clinicians...
February 2017: Annals of Dermatology
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