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https://www.readbyqxmd.com/read/28719960/evaluation-of-boldine-activity-against-intracellular-amastigotes-of-leishmania-amazonensis
#1
Isabel Cristina Salama, Cristina Arrais-Lima, Wagner Welber Arrais-Silva
Leishmaniasis is a neglected and endemic disease that affects poorest population mainly in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The aim of this study was to investigate in vitro activity of boldine against Leishmania amazonensis murine cell infection. Boldine ((S)-2,9-dihydroxy-1,10-dimethoxy-aporphine) is an aporphine alkaloid found abundantly in the leaves/bark of boldo (Peumus boldus Molina), a widely distributed tree native to Chile...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719951/neuronal-apoptosis-pathological-basis-of-behavioral-dysfunctions-induced-by-angiostrongylus-cantonensis-in-rodents-model
#2
Shiqi Luo, Lisi OuYang, Jie Wei, Feng Wu, Zhongdao Wu, Wanlong Lei, Dongjuan Yuan
Angiostrongylus cantonensis invades the central nervous system (CNS) of humans to induce eosinophilic meningitis and meningoencephalitis and leads to persistent headache, cognitive dysfunction, and ataxic gait. Infected mice (nonpermissive host), admittedly, suffer more serious pathological injuries than rats (permissive host). However, the pathological basis of these manifestations is incompletely elucidated. In this study, the behavioral test, histological and immunohistochemical techniques, and analysis of apoptotic gene expression, especially caspase-3, were conducted...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719897/clinical-manifestations-and-prognostic-factors-of-pneumocystis-jirovecii-pneumonia-without-hiv
#3
Nobuhiro Asai, Shinji Motojima, Yoshihiro Ohkuni, Ryo Matsunuma, Takuya Iwasaki, Kei Nakashima, Keiji Sogawa, Tamao Nakashita, Norihiro Kaneko
INTRODUCTION: Pneumocystis jirovecii pneumonia (PCP) can occur in HIV patients but also in those without HIV (non-HIV PCP) but with other causes of immunodeficiency including malignancy or rheumatic diseases. OBJECTIVE AND METHODS: To evaluate the clinical presentation and prognostic factors of non-HIV PCP, we retrospectively reviewed all patients diagnosed as having PCP without HIV at Kameda Medical Center, Chiba, Japan, from January 2005 until June 2012. For the purpose of examining a prognostic factor for non-HIV PCP with 30-day mortality, we compared the characteristics of patients, clinical symptoms, radiological images, Eastern Cooperative Oncology Group performance status (PS), and the time from the onset of respiratory symptoms to the start of therapy, in both survival and fatality groups...
July 19, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28719892/cinnamaldehyde-ameliorates-diet-induced-obesity-in-mice-by-inducing-browning-of-white-adipose-tissue
#4
Jiacheng Zuo, Dandan Zhao, Na Yu, Xin Fang, Qianqian Mu, Yue Ma, Fangfang Mo, Rui Wu, Rufeng Ma, Lili Wang, Ruyuan Zhu, Haixia Liu, Dongwei Zhang, Sihua Gao
BACKGROUND/AIMS: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) has been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed to investigate the potential anti-obesity effects of CA on mice fed a high-fat diet (HFD) and to explore the possible mechanisms involved. METHODS: Male C57BL/6J mice fed an HFD for 12 weeks were supplemented with CA (40 mg/kg/day) via gavage for an additional 8 weeks...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28719888/inhibition-of-single-routes-of-intracellular-signaling-is-not-sufficient-to-neutralize-the-biphasic-disturbance-of-a-retinal-endothelial-cell-barrier-induced-by-vegf-a165
#5
Heidrun L Deissler, Gerhard K Lang, Gabriele E Lang
BACKGROUND/AIMS: Hallmark of diabetic macular edema is the enhanced permeability of retinal endothelial cells (REC) induced by vascular endothelial growth factor (VEGF-A165), which acts through activating specific receptors. To improve the predictability of inhibitors' potentials to block harmful effects of VEGF-A165, we investigated if its signaling pathways triggered in REC are redundant. METHODS: Immortalized bovine REC monolayers were treated with inhibitors specific for various protein kinases in combination with VEGF-A165...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28719882/antileishmanial-activity-and-tubulin-polymerization-inhibition-of-podophyllotoxin-derivatives-on-leishmania-infantum
#6
José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Rosa M Reguera, María Ángeles Castro, María Victoria Rojo, Carolina Santiago, Andrés Abad, Pablo Anselmo García, José Luis López-Pérez, Arturo San Feliciano, Rafael Balaña-Fouce
Leishmania microtubules play an important role not only in cell division, but also in keeping the shape of the parasite and motility of its free-living stages. Microtubules result from the self-assembly of alpha and beta tubulins, two phylogenetically conserved and very abundant eukaryotic proteins in kinetoplastids. The colchicine binding domain has inspired the discovery and development of several drugs currently in clinical use against parasites. However, this domain is less conserved in kinetoplastids and may be selectively targeted by new compounds...
June 28, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28719876/photoelectrocatalytic-degradation-of-methylene-blue-using-f-doped-tio2-photoelectrode-under-visible-light-irradiation
#7
Dong Liu, Renwen Tian, Jianqiao Wang, Er Nie, Xianqing Piao, Xin Li, Zhuo Sun
Photoelectrocatalysis (PEC) has attracted great interest due to cost effectiveness and high efficiency in water treatment. In this study, F doped TiO2 (F-TiO2) photoelectrodes with honeycomb like morphology were prepared, and the PEC performance was investigated. F-TiO2 particles that showed enhanced absorption of visible light were synthesized via a sol-gel method. F-TiO2 particles were anchored onto the surface of F-doped SnO2 glass by a screen-printing method to prepare the F-TiO2 photoelectrodes. The PEC performance of the F-TiO2 photoelectrodes was investigated via the degradation of methylene blue (MB) under visible light irradiation...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719875/novel-magnetic-carboxyl-modified-hypercrosslinked-resins-for-effective-removal-of-typical-ppcps
#8
Jing Jin, Tianyu Feng, Yan Ma, Wei Wang, Yunshu Wang, Qing Zhou, Aimin Li
A series of novel magnetic carboxyl modified hypercrosslinked resins were successfully prepared via a sequence of suspension polymerization, hydrolysis and post-crosslinking reactions. The serial resins possessed both high cation exchange capacity and high specific surface area with MA-10 having the supreme specific surface area of 1238.65 m(2)/g and MA-70 having the largest exchange capacity of 6.45 mmol/g. The serial resins exhibited excellent adsorption capacity of typical PPCPs including chloramphenicol, atenolol, ibuprofen and tetracycline, which were neutral, cationic, anionic and zwitterionic respectively in natural water...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719874/combined-effects-of-temperature-and-clomazone-gamit-%C3%A2-on-oxidative-stress-responses-and-b-esterase-activity-of-physalaemus-nattereri-leiuperidae-and-rhinella-schneideri-bufonidae-tadpoles
#9
Juliane Silberschmidt Freitas, Andreia Arantes Felício, Fabrício Barreto Teresa, Eduardo Alves de Almeida
Temperature is an important factor influencing the toxicity of chemicals in aquatic environments. Neotropical tadpoles experience large temperature fluctuations in their habitats and many species are distributed in areas impacted by agriculture. This study evaluated the effects caused by the exposure to clomazone (Gamit(®)) at different temperatures (28, 32 and 36 °C) on biochemical stress responses and esterase activities in Physalaemus nattereri and Rhinella schneideri tadpoles. Results evidenced that temperature modulates the effects of clomazone on biochemical response of tadpoles...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719870/effects-of-endocrine-disrupting-chemicals-on-estrogen-receptor-alpha-and-heat-shock-protein-60-gene-expression-in-primary-cultures-of-loggerhead-sea-turtle-caretta-caretta-erythrocytes
#10
Paolo Cocci, Martina Capriotti, Gilberto Mosconi, Francesco Alessandro Palermo
The loggerhead turtle (Caretta caretta) can be considered a good indicator species for studying the ecological impact of endocrine disrupting chemicals (EDCs) on wildlife. However, the effect of these environmental pollutants on nuclear steroid hormone signaling has not yet been addressed in sea turtles mainly due to the legal constraints of their endangered status. Here we describe the use of primary erythrocyte cell cultures as in vitro models for evaluating the effects of different EDCs on the expression of estrogen receptor α (ERα)...
July 15, 2017: Environmental Research
https://www.readbyqxmd.com/read/28719867/tissue-homeostasis-and-aging-new-insight-from-the-fly-intestine
#11
REVIEW
Louis Gervais, Allison J Bardin
Adult somatic stem cells facilitate tissue homeostasis throughout the life of the organism. The mechanisms controlling stem cell activity are under intense scrutiny, with the aims of elucidating how they mediate tissue homeostasis, contribute to age-related decline of adult tissues, and promote tumorigenesis. Recently, the use of model systems such as the Drosophila intestine has enriched our understanding of how stem cells integrate local and systemic signals to maintain tissue and organs function in physiological conditions of homeostasis or after damage...
July 15, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28719866/cell-competition-in-mammals-novel-homeostatic-machinery-for-embryonic-development-and-cancer-prevention
#12
REVIEW
Takeshi Maruyama, Yasuyuki Fujita
In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition and was originally discovered in Drosophila. Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium; a process termed EDAC (Epithelial Defense Against Cancer)...
July 15, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28719864/in-vivo-magnetic-resonance-imaging-of-pancreatic-tumors-using-iron-oxide-nanoworms-targeted-with-ptr86-peptide
#13
Yasaman Ahmadi, Genady Kostenich, Mor Oron-Herman, Wolfgang Wadsak, Markus Mitterhauser, Arie Orenstein, Siroos Mirzaei, Peter Knoll
To cut the high mortality rate of malignant disease such as pancreatic cancer, development of newly diagnostic probes for early stage detection of tumor lesions is required. Multimodal imaging nanoprobes allowing targeted and real time functional/anatomical imaging of tumors meet the demands. For this purpose, a MRI/optical dual-modality probe based on biodegradable magnetic iron oxide nanoworms has been developed. The cross-linked surface of nanoworms were anchored to fluorescent dyes and to FITC.PTR86; a novel synthetic peptide with high affinity towards somatostatin receptors...
July 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719863/evaluation-of-platelet-adhesion-and-activation-on-polymers-round-robin-study-to-assess-inter-center-variability
#14
S Braune, C Sperling, M F Maitz, U Steinseifer, J Clauser, B Hiebl, S Krajewski, H P Wendel, F Jung
The regulatory agencies provide recommendations rather than protocols or standard operation procedures for the hemocompatibility evaluation of novel materials e.g. for cardiovascular applications. Thus, there is a lack of specifications with regard to test setups and procedures. As a consequence, laboratories worldwide perform in vitro assays under substantially different test conditions, so that inter-laboratory and inter-study comparisons are impossible. Here, we report about a prospective, randomized and double-blind multicenter trial which demonstrates that standardization of in vitro test protocols allows a reproducible assessment of platelet adhesion and activation from fresh human platelet rich plasma as possible indicators of the thrombogenicity of cardiovascular implants...
July 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719862/green-biosynthesis-of-silver-nanoparticles-using-leaves-extract-of-artemisia-vulgaris-and-their-potential-biomedical-applications
#15
Tahir Rasheed, Muhammad Bilal, Hafiz M N Iqbal, Chuanlong Li
Biosynthesis of nanoparticles from plant extracts is receiving enormous interest due to their abundant availability and a broad spectrum of bioactive reducing metabolites. In this study, the reducing potential of Artemisia vulgaris leaves extract (AVLE) was investigated for synthesizing silver nanoparticles without the addition of any external reducing or capping agent. The appearance of blackish brown color evidenced the complete synthesis of nanoparticles. The synthesized silver nanoparticles were characterized by UV-vis spectroscopy, scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscope (TEM), atomic force microscopy (AFM) and Fourier transforms infrared spectroscopy (FT-IR) analysis...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719861/stabilized-cationic-dipeptide-capped-gold-silver-nanohybrids-towards-enhanced-antibacterial-and-antifungal-efficacy
#16
Manish Bajaj, Satish K Pandey, Tamanna Nain, Surinder K Brar, Prabhjot Singh, Shivakanksha Singh, Nishima Wangoo, Rohit K Sharma
The nanoparticles of silver/gold and cationic peptides have been recognized as potent antimicrobials for long, but their combined effect has so far not been explored. The present study reports the green synthesis of short cationic dipeptide stabilized AuNPs/AgNPs based nanohybrid materials. It thoroughly investigates the effect of conjugation of short cationic peptides on the antimicrobial properties of metallic nanoparticles. In the context of the antimicrobial evaluation of synthesized nanoconjugates, it was observed that peptide capped AgNPs exhibited higher antimicrobial activity as compared to peptide capped AuNPs as well as native peptides and unconjugated metallic nanoparticles...
July 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719855/high-fat-diet-and-aging-interact-to-produce-neuroinflammation-and-impair-hippocampal-and-amygdalar-dependent-memory
#17
Sarah J Spencer, Heather D'Angelo, Alita Soch, Linda R Watkins, Steven F Maier, Ruth M Barrientos
More Americans are consuming diets higher in saturated fats and refined sugars than ever before, and based on increasing obesity rates, this is a growing trend among older adults as well. While high saturated fat diet (HFD) consumption has been shown to sensitize the inflammatory response to a subsequent immune challenge in young adult rats, the inflammatory effect of HFD in the already-vulnerable aging brain has not yet been assessed. Here, we explored whether short-term (3 days) consumption of HFD would serve as a neuroinflammatory trigger in aging animals, leading to cognitive deficits...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28719852/rapid-gamma-spectrometric-analysis-of-soil-samples-after-radioactive-fallout-using-a-conjugate-view-technique
#18
M Isaksson, M Fahlström, N Ossipova, K Rosén
A method for fast determination of the activity in soil samples by measuring a fresh soil core sample from both ends with an HPGe-detector is proposed. The method was tested by simulations, as well as by measurements on spiked soil samples. Both simulations and measurements showed that the geometrical mean of the count rates when the sample is measured twice, with the bottom and the top end, respectively, facing the detector closely resembles the count rate from a measurement on a homogenized sample. Therefore, an efficiency calibration for homogenized samples could be used even if the activity is highly inhomogeneous in the soil core, as is the case with fresh fallout...
July 15, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28719851/interaction-of-cholera-toxin-b-subunit-with-t-and-b-lymphocytes
#19
Elena V Navolotskaya, Vladimir B Sadovnikov, Dmitry V Zinchenko, Valery M Lipkin, Vladimir P Zav'yalov
We have prepared (125)I-labeled cholera toxin B subunit ((125)I-labeled CT-B, a specific activity of 98Ci/mmol) and found that its binding to T and B lymphocytes from the blood of healthy donors was high-affinity (Kd 2.8 and 3.0nM, respectively). The binding of labeled protein was completely inhibited by unlabeled thymosin-α1 (TM-α1), interferon-α2 (IFN-α2), and the synthetic peptide LKEKK that corresponds to residues 16-20 in TM-α1 and 131-135 in IFN-α2, but was not inhibited by the synthetic peptide KKEKL with inverted amino acid sequence (Ki>10μM)...
July 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28719847/high-photocatalytic-activity-of-hierarchical-sio2-c-doped-tio2-hollow-spheres-in-uv-and-visible-light-towards-degradation-of-rhodamine-b
#20
Ying Zhang, Juanrong Chen, Li Hua, Songjun Li, Xuanxuan Zhang, Weichen Sheng, Shunsheng Cao
Ongoing research activities are targeted to explore high photocatalytic activity of TiO2-based photocatalysts for the degradation of environmental contaminants under UV and visible light irradiation. In this work, we devise a facile, cost-effective technique to in situ synthesize hierarchical SiO2@C-doped TiO2 (SCT) hollow spheres for the first time. This strategy mainly contains the preparation of monodisperse cationic polystyrene spheres (CPS), sequential deposition of inner SiO2, the preparation of the sandwich-like CPS@SiO2@CPS particles, and formation of outer TiO2...
July 10, 2017: Journal of Hazardous Materials
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