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https://www.readbyqxmd.com/read/29344954/mixed-ductal-lobular-carcinomas-evidence-for-progression-from-ductal-to-lobular-morphology
#1
Amy E McCart Reed, Jamie R Kutasovic, Katia Nones, Jodi M Saunus, Leonard Da Silva, Felicity Newell, Stephen Kazakoff, Lewis Melville, Janani Jayanthan, Ana Cristina Vargas, Lynne E Reid, Jonathan Beesley, Xiao Qing Chen, Anne Marie Patch, D David Clouston, Alan Porter, Elizabeth Evans, John V Pearson, Georgia Chenevix-Trench, Margaret C Cummings, Nic Waddell, Sunil R Lakhani, Peter T Simpson
Mixed ductal-lobular carcinomas (MDL) display both ductal and lobular morphology, and are an archetypal example of intra-tumour morphological heterogeneity. The mechanisms underlying coexistence of these different morphologic entities are poorly understood, although theories include that these components either represent 'collision' of independent tumours or evolve from a common ancestor. We performed comprehensive clinico-pathological analysis of a cohort of 82 MDLs and found: i) MDLs more frequently co-exist with ductal carcinoma in situ (DCIS) than lobular carcinoma in situ (LCIS); ii) the E-cadherin-catenin complex was normal in the ductal component in 77...
January 18, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29344435/synchronous-uterine-metastases-from-breast-cancer-case-study-and-literature-review
#2
REVIEW
Aisha Akhtar, Atul Ratra, Yana Puckett, Abu Baker Sheikh, Catherine A Ronaghan
Breast cancer rarely metastasizes to the uterus. Here, we report two breast cancer patients with synchronous metastases to the uterus. Case 1 highlights a 46-year-old female with invasive ductal carcinoma who presented with a breast mass and was found to have uterine enlargement on positron emission tomography (PET) scan. Biopsy revealed a metastatic 4 mm focus of breast cancer in the background of endometrial hyperplasia. Case 2 reports a 62-year-old postmenopausal female diagnosed with lobular carcinoma of the breast following an abnormal screening mammogram...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29344276/the-clinicopathological-features-and-survival-outcomes-of-different-histological-subtypes-in-triple-negative-breast-cancer
#3
Hong-Ye Liao, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, San-Gang Wu
Purpose: To determine the clinicopathological features and survival outcomes of triple-negative breast cancer (TNBC) according to different histological subtypes. Methods: Using the Surveillance, Epidemiology, and End Results database, we included TNBC cases in 2010-2013. The effect of histological subtype on breast cancer-specific survival (BCSS) and overall survival (OS) were analyzed using univariate and multivariate analyses. Results: A total of 19,900 patients were identified. Infiltrating ductal carcinoma not otherwise specified accounted for 91...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29339079/diagnostic-usefulness-of-combination-of-diffusion-weighted-imaging-and-t2wi-including-apparent-diffusion-coefficient-in-breast-lesions-assessment-of-histologic-grade
#4
Keum Won Kim, Cherie M Kuzmiak, Young Joong Kim, Jae Young Seo, Hae Kyoung Jung, Mu-Sik Lee
PURPOSE: This study aimed to compare the diagnostic values of a combination of diffusion-weighted imaging and T2-weighted imaging (DWI-T2WI) with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and to evaluate the correlation of DWI with the histologic grade in breast cancer. MATERIALS AND METHODS: This study evaluated a total of 169 breast lesions from 136 patients who underwent both DCE-MRI and DWI (b value, 1000s/mm2). Morphologic and kinetic analyses for DCE-MRI were classified according to the Breast Imaging-Reporting and Data System...
January 12, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29334616/preoperative-breast-magnetic-resonance-imaging-use-by-breast-density-and-family-history-of-breast-cancer
#5
Louise M Henderson, Rebecca A Hubbard, Weiwei Zhu, Julie Weiss, Karen J Wernli, Martha E Goodrich, Karla Kerlikowske, Wendy DeMartini, Elissa M Ozanne, Tracy Onega
BACKGROUND: Use of preoperative breast magnetic resonance imaging (MRI) among women with a new breast cancer has increased over the past decade. MRI use is more frequent in younger women and those with lobular carcinoma, but associations with breast density and family history of breast cancer are unknown. MATERIALS AND METHODS: Data for 3075 women ages >65 years with stage 0-III breast cancer who underwent breast conserving surgery or mastectomy from 2005 to 2010 in the Breast Cancer Surveillance Consortium were linked to administrative claims data to assess associations of preoperative MRI use with mammographic breast density and first-degree family history of breast cancer...
January 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29331306/primary-mucinous-eccrine-carcinoma-of-the-buccal-space-a-case-report-and-review-of-the-literature
#6
Kirkland N Lozada, Muhammed S Qazi, Azita S Khorsandi, Raymond L Chai
IMPORTANCE: Mucinous eccrine carcinoma is a rare entity that most commonly affects the head and neck. Due to its low frequency of occurrence, review of its etiology, histopathology, and treatment strategies is beneficial to all clinicians who may encounter similar appearing masses. OBSERVATION: An 84-year-old male presented with a blue mass on the left cheek. This mass started as a small bump and grew significantly over one year. His primary care physician monitored its growth and ultimately referred to an otolaryngologist...
January 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29329752/role-of-frozen-section-in-sentinel-lymph-node-biopsy-for-breast-cancer-in-the-era-of-the-acosog-z0011-and-ibcsg-23-10-trials
#7
Augusto Lombardi, Giuseppe Nigri, Stefano Maggi, Gianluca Stanzani, Valeria Vitale, Andrea Vecchione, Alessandro Nania, Claudio Amanti
BACKGROUND: Intraoperative frozen sections (FS) of sentinel lymph nodes (SLN) were evaluated to avoid the need for deferred axillary lymph node dissection (ALND) in patients with early breast cancer (EBC). However, FS has low sensitivity for detecting micro-metastases (<2 mm), resulting in patients who later undergo deferred ALND. The aim of the study was to determine the best clinical approach for selecting patients who would derive real benefit from ALND, as well as to minimize the functional and psychological damage caused by delayed surgery, and the risk of undertreating EBC patients...
January 9, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29323551/gamma-imaging-guided-minimally-invasive-breast-biopsy-initial-clinical-experience
#8
Rachel F Brem, Anita K Mehta, Jocelyn A Rapelyea, Esma A Akin, Adriana M Bazoberry, Christel D Velasco
OBJECTIVE: The purpose of this study was to evaluate our initial experience with gamma imaging-guided vacuum-assisted breast biopsy in women with abnormal findings. MATERIALS AND METHODS: A retrospective review of patients undergoing breast-specific gamma imaging (BSGI), also known as molecular breast imaging (MBI), between April 2011 and October 2015 found 117 nonpalpable mammographically and sonographically occult lesions for which gamma imaging-guided biopsies were recommended...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29322116/efficiency-of-imaging-modalities-in-male-breast-disease-can-ultrasound-give-additional-information-for-assessment-of-gynecomastia-evolution
#9
Özgür Sarıca, A Nedim Kahraman, Enis Öztürk, Memik Teke
Objective: The purpose of this study is to present mammography and ultrasound findings of male breast lesions and to investigate the ability of diagnostic modalities in estimating the evolution of gynecomastia. Materials and Methods: Sixty-nine male patients who admitted to Taksim and Bakirkoy Education and Research Hospitals and underwent mammography (MG) and ultrasonography (US) imaging were retrospectively evaluated. Duration of symptoms and mammographic types of gynecomastia according to Appelbaum's classifications were evaluated, besides the sonographic findings in mammographic types of gynecomastia...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29322114/characteristics-of-special-type-breast-tumors-in-our-center
#10
Tonguç Utku Yılmaz, Levent Trabzonlu, Sertaç Ata Güler, Mehmet Ali Baran, Gökhan Pösteki, Cengiz Erçin, Zafer Utkan
Objective: Breast cancer is a heterogeneous disease with different histological types. Ductal breast cancer constitutes the vast majority of the breast cancers. However limited data are present in the rest of breast cancers called special or rare type breast cancers. Here in this study, we tried to describe the clinical features of special type breast cancers in our center. Materials and Methods: Retrospective descriptive study was performed in Kocaeli University School of Medicine, Department of General Surgery between January 2000 and January 2016...
January 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29317235/differentiating-breast-carcinoma-with-signet-ring-features-from-gastrointestinal-signet-ring-carcinoma-assessment-of-immunohistochemical-markers
#11
Yiang Hui, Yihong Wang, Gahie Nam, Jacqueline Fanion, Ashlee Sturtevant, Kara A Lombardo, Murray B Resnick
Signet-ring morphology is recognized throughout the gastrointestinal tract. However, this pattern may be observed in other primary sites giving rise to diagnostic challenges in the work-up of metastases. Relatively newer immunohistochemical markers have not been evaluated in this context. We assessed expression patterns of several common immunohistochemical markers in tumors with signet-ring morphology to delineate a pragmatic approach to this differential diagnosis. Primary breast and gastrointestinal carcinomas showing signet-ring features were reviewed...
January 6, 2018: Human Pathology
https://www.readbyqxmd.com/read/29312836/malignant-epithelial-transformation-in-phyllodes-tumor-a-population-based-case-series
#12
Ralph L Widya, Myra F Rodrigues, Pauline T Truong, Peter H Watson, Lorna M Weir, Margaret A Knowling, Elaine S Wai
Background Phyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT. Methods From an institutional database of 183 patients with newly diagnosed PT referred to a Canadian provincial cancer institution between 1999 and 2014, 11 cases of PT with concomitant in situ or invasive carcinoma were identified. Descriptive analysis was performed to document the characteristics, treatment and outcomes of this cohort...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29310602/clinical-and-pathological-factors-influencing-survival-in-a-large-cohort-of-triple-negative-breast-cancer-patients
#13
Silvana Anna Maria Urru, Silvano Gallus, Cristina Bosetti, Tiziana Moi, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Francesca Sanges, Giovanna Pira, Alessandra Manca, Dolores Palmas, Matteo Floris, Anna Maria Asunis, Francesco Atzori, Ciriaco Carru, Maurizio D'Incalci, Massimo Ghiani, Vincenzo Marras, Daniela Onnis, Maria Cristina Santona, Giuseppina Sarobba, Enrichetta Valle, Luisa Canu, Sergio Cossu, Alessandro Bulfone, Paolo Cossu Rocca, Maria Rosaria De Miglio, Sandra Orrù
BACKGROUND: To provide further information on the clinical and pathological prognostic factors in triple-negative breast cancer (TNBC), for which limited and inconsistent data are available. METHODS: Pathological characteristics and clinical records of 841 TNBCs diagnosed between 1994 and 2015 in four major oncologic centers from Sardinia, Italy, were reviewed. Multivariate hazard ratios (HRs) for mortality and recurrence according to various clinicopathological factors were estimated using Cox proportional hazards models...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29301491/pancreatic-panniculitis-the-bright-side-of-the-moon-in-solid-cancer-patients
#14
Elena Guanziroli, Antonella Colombo, Antonella Coggi, Raffaele Gianotti, Angelo Valerio Marzano
BACKGROUND: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes...
January 4, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29299726/observation-versus-excision-of-lobular-neoplasia-on-core-needle-biopsy-of-the-breast
#15
Hank Schmidt, Brittany Arditi, Margaux Wooster, Christina Weltz, Laurie Margolies, Ira Bleiweiss, Elisa Port, Shabnam Jaffer
PURPOSE: Controversy surrounds management of lobular neoplasia (LN), [atypical lobular hyperplasia (ALH) or lobular carcinoma in situ (LCIS)], diagnosed on core needle biopsy (CNB). Retrospective series of pure ALH and LCIS reported "upgrade" rate to DCIS or invasive cancer in 0-40%. Few reports document radiologic/pathologic correlation to exclude cases of discordance that are the likely source of most upgrades, and there is minimal data on outcomes with follow-up imaging and clinical surveillance...
January 3, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29286226/almost-complete-lack-of-human-cytomegalovirus-and-human-papillomaviruses-genome-in-benign-and-malignant-breast-lesions-in-shiraz-southwest-of-iran
#16
Sahar Bakhtiyrizadeh, Seyed Younes Hosseini, Ramin Yaghobi, Aliakbar Safaei, Jamal Sarvari
Breast cancer ranks as the most common cancer among women worldwide. There have been controversial reports regarding contributions of human papillomaviruses (HPVs) and human cytomegalovirus (HCMV) to its development. The aim of this study was to determine the frequency of HPV and HCMV positivity in benign and malignant breast tumors. Materials and Methods: Formalin fixed paraffin-embedded tissue specimens of 150 breast cancers (invasive ductal and lobular carcinomas) and 150 non-malignant breast lesions (fibroadenomas, fibrocystic disease and adenosis) were examined...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29286208/diffuse-liver-infiltration-by-lobular-breast-carcinoma-shear-wave-elastography-as-gold-standard-imaging-study
#17
Armando Orlandi, Matteo Garcovich, Mariantonietta di Salvatore, Laura Riccardi, Vincenzo Arena, Maria Alessandra Calegari, Maurizio Pompili, Carlo Barone
No abstract text is available yet for this article.
December 29, 2017: Breast Journal
https://www.readbyqxmd.com/read/29281999/invasive-micropapillary-carcinoma-of-the-breast-overexpresses-muc4-and-is-associated-with-poor-outcome-to-adjuvant-trastuzumab-in-her2-positive-breast-cancer
#18
María F Mercogliano, Gloria Inurrigarro, Mara De Martino, Leandro Venturutti, Martín A Rivas, Rosalía Cordo-Russo, Cecilia J Proietti, Elmer A Fernández, Isabel Frahm, Sabrina Barchuk, Daniel H Allemand, Silvina Figurelli, Ernesto Gil Deza, Sandra Ares, Felipe G Gercovich, Eduardo Cortese, Matías Amasino, Pablo Guzmán, Juan C Roa, Patricia V Elizalde, Roxana Schillaci
BACKGROUND: Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangement. IMPC is an aggressive tumor with poor clinical outcome. In addition, this histological subtype usually expresses human epidermal growth factor receptor 2 (HER2) which also correlates with a more aggressive tumor. In this work we studied the clinical significance of IMPC in HER2-positive breast cancer patients treated with adjuvant trastuzumab...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29273054/significant-suppression-of-radiation-dermatitis-in-breast-cancer-patients-using-a-topically-applied-adrenergic-vasoconstrictor
#19
James F Cleary, Bethany M Anderson, Jens C Eickhoff, Deepak Khuntia, William E Fahl
BACKGROUND: Our previous studies showed that vasoconstrictor applied topically to rat skin minutes before irradiation completely prevented radiodermatitis. Here we report on a Phase IIa study of topically applied NG12-1 vasoconstrictor to prevent radiodermatitis in post-lumpectomy breast cancer patients who received at least 40 Gray to the whole breast using standard regimens. METHODS: Patients had undergone surgery for Stage Ia, Ib, or IIa infiltrating ductal or lobular carcinoma of the breast or ductal carcinoma in situ...
December 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29238489/comparison-of-mammography-and-ultrasonography-findings-with-pathology-results-in-patients-with-breast-cancer-in-birjand-iran
#20
Fatemeh Haghighi, Ghodratollah Naseh, Mahyar Mohammadifard, Naeeme Abdollahi
Background: Early diagnosis of breast cancer, the incidence of which among Iranian women is about a decade earlier than in developed countries, is important. Objective: To compare mammography and ultrasonography findings with those of pathology in patients with breast cancer. Methods: This descriptive cross-sectional study was performed using medical records of 79 patients with breast malignancies, who were referred to Imam Reza Hospital and private laboratories of Birjand, Iran, from December 2012 to December 2014...
October 2017: Electronic Physician
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