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https://www.readbyqxmd.com/read/28819437/impact-of-detection-method-and-accompanying-ductal-carcinoma-in-situ-on-prognosis-of-t1a-bn0-breast-cancer
#1
Shih-Che Shen, Shir-Hwa Ueng, Chan-Keng Yang, Chi-Chang Yu, Yung-Feng Lo, Hsien-Kun Chang, Yung-Chang Lin, Shin-Cheh Chen
Background: T1a,bN0 breast cancer is not easily detected. Before mammography became widespread, most cases were discovered only after the development of symptoms. The presence of ductal carcinoma in situ (DCIS) affects the detectability of associated invasive cancer; however, the prognostic value of concomitant DCIS is controversial. This study compared the characteristics of screening-detected and symptom-detected T1a,bN0 breast cancer, and investigated the impact of accompanying DCIS on detection and prognosis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28816351/recent-advances-in-genomic-profiling-of-adenosquamous-carcinoma-of-the-pancreas
#2
Rebecca Marcus, Anirban Maitra, Jason Roszik
Adenosquamous carcinoma of the pancreas (ASCP) is a mixed tumor type which contains squamous cell carcinoma and also ductal adenocarcinoma components. Due to the rarity of this malignancy, only very limited genomic profiling has been performed. A recent paper by Fang et al. published in The Journal of Pathology contributed to our knowledge of genomic alterations by performing whole genome and exome sequencing of 17 ASCP tumors. They found major genomic similarities to pancreatic ductal adenocarcinoma; however, the p53 pathway was altered in a greater proportion of cases, while a high frequency of 3p loss was a distinct copy number alteration pattern observed in ASCP...
August 17, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28816144/comparison-of-treatment-outcome-between-invasive-lobular-and-ductal-carcinomas-in-patients-receiving-partial-breast-irradiation-with-intraoperative-electrons
#3
Maria Cristina Leonardi, Patrick Maisonneuve, Mauro Giuseppe Mastropasqua, Federica Cattani, Giuseppe Fanetti, Anna Morra, Roberta Lazzari, Federica Bazzani, Mariangela Caputo, Nicole Rotmensz, Marianna Alessandra Gerardi, Rosalinda Ricotti, Viviana Enrica Galimberti, Paolo Veronesi, Samantha Dicuonzo, Giuseppe Viale, Barbara Alicja Jereczek-Fossa, Roberto Orecchia
PURPOSE: To investigate the local outcome of patients after accelerated partial breast irradiation with intraoperative electrons (IORT) for invasive lobular carcinoma (ILC) compared with invasive ductal carcinoma (IDC). METHODS AND MATERIALS: From 1999 to 2007, 2173 patients were treated with breast-conserving surgery and IORT (21 Gy/1 fraction) as the sole local treatment: 252 patients with ILC (11.6%) were compared with 1921 patients with IDC in terms of local control...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816013/new-neurotensin-analogue-radiolabeled-by-99m-technetium-as-a-potential-agent-for-tumor-identification
#4
Iman Emrarian, Nourollah Sadeghzadeh, Seyed Mohammad Abedi, Saeid Abediankenari
INTRODUCTION: It has been shown that more than 75% of ductal pancreatic adenocarcinomas are overexpress neurotensin (NT) receptors. Overexpression of NT receptors has been reported in various human tumor types. Hence, a non-invasive diagnosis and staging method could be very beneficial. In this work, we describe radiolabeling and evaluation of new neurotensin analogues to target neurotensin receptor-positive tumors such as pancreatic carcinoma. METHODS: Radiolabeling was performed at 95°C for 10 min using(99m) Tc in the presence of tricine/EDDA exchange labeling...
August 16, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28812305/point-should-radiation-therapy-after-surgery-for-ductal-carcinoma-in-situ-be-standard-practice
#5
Camille Berriochoa, Carisa Bohnak, Nicole Chahine, Chirag Shah
No abstract text is available yet for this article.
August 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28811827/pharmacodynamics-and-medicinal-chemistry-of-an-external-chinese-herbal-formula-for-mammary-precancerous-lesions
#6
Ruixue Chen, Guijuan Zhang, Yi Ma, Fengjie Bie, Hongxia Fan, Min Ma
Ruyan Neixiao Cream (RYNXC) is a traditional Chinese herbal formula for treating mammary precancerous disease. This study was carried out to investigate in vivo anticancer effect of RYNXC and multiple constituents. 32 virginal Sprague-Dawley rats were randomly divided into blank control group (BC), mammary precancer models group (MODEL), tamoxifen group (TAM), and Ruyan Neixiao Cream group (RYNXC). TAM was intervened by tamoxifen; RYNXC was intervened by Ruyan Neixiao Cream. The chromatographic separation was performed by high performance liquid chromatography (HPLC) coupled with mass spectrometry (MS)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28810292/-clinicopathologic-features-of-mammary-microglandular-adenosis-with-carcinoma-a-study-of-5-cases
#7
W Chen, C Wang, Z H Zhang, W M Zhang, Y Xu, G X Song
Objective: To study the clinicopathologic, immunohistochemical features, differential diagnoses and prognosis of mammary microglandular adenosis with carcinoma (MGACA) with micropapillary pattern. Methods: Five cases of MGACA were collected from 2010 to 2016 and reviewed for their clinical, histologic features and outcome.EnVision method were done for S-100 protein, cytokeratin (CK), p63, Calponin, smooth muscle myosin heavy chain (SMMHC), PR, ER and HER2. Results: Histologically, microglandular adenosis(MGA), atypical MGA (AMGA) and invasive carcinoma were seen in all five cases of MGACA...
August 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28807830/usp5-promotes-tumorigenesis-and-progression-of-pancreatic-cancer-by-stabilizing-foxm1-protein
#8
Xin-Yan Li, Hai-Yun Wu, Xiao-Fang Mao, Li-Xin Jiang, Yong-Xiang Wang
Increased ubiquitin-specific protease 5 (USP5) has been associated with tumorigenesis of malignancy including glioblastoma, melanoma and hepatocellular carcinoma. However, the role of USP5 in tumorigenesis of pancreatic ductal adenocarcinoma (PDAC) has not been studied yet. In this study, we demonstrated that USP5 was significantly upregulated in a panel of PDAC cell lines and correlated with FoxM1 protein expression. USP5 knockdown inhibited proliferation of PANC-1 and SW1990, two PDAC cell lines. In the mouse xenografted pancreatic tumor model, suppression of USP5 significantly decreased tumor growth, correlated with down regulation of FoxM1...
August 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28807821/popdc1-is-suppressed-in-human-breast-cancer-tissues-and-is-negatively-regulated-by-egfr-in-breast-cancer-cell-lines
#9
Johanna Ndamwena Amunjela, Steven John Tucker
Breast cancer molecular heterogeneity has resulted in disparities in therapeutic response and targeting of molecular subtypes of breast cancer. This necessitates identification and validation of novel therapeutic targets for breast cancer treatment. Suppression of Popeye domain-containing (POPDC) proteins is hypothesized to promote malignant cell behaviour and poor clinical outcomes in various cancers. We aimed to determine whether POPDC proteins are suppressed in human ductal carcinoma tissues and if this correlates to clinical progression and Her2 status...
August 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28807337/evaluation-of-cd43-expression-in-non-hematopoietic-malignancies
#10
Bjorn H Batdorf, Steven H Kroft, Paul R Hosking, Alexandra M Harrington, Alexander C Mackinnon, Horatiu Olteanu
OBJECTIVES: CD43 is normally expressed only on the surface of leukocytes, and is considered a sensitive and specific marker for hematologic malignancies. As such, it may have diagnostic utility in confirming hematolymphoid lineage in cases that are negative for CD45. Aberrant CD43 expression has been described in non-hematopoietic tumors, although literature data on this topic is variable and sometimes contradictory. To clarify and expand on existing literature findings, we evaluated CD43 expression by immunohistochemistry (IHC) in a large cohort (307) of non-hematopoietic neoplasms, including poorly differentiated malignancies...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28806663/management-of-breast-ductal-carcinoma-in-situ-in-catalonia-spain-results-from-the-grup-oncologic-calal%C3%A3-occit%C3%A3-catalonia-survey-with-9-year-follow-up
#11
M J Cambra, B Farrús, F Moreno, Ll Anglada, M Arenas, R Ballester, J Casals, M Cusidó, V García, C Gutiérrez, M Mollà, A Pedro, V Reyes, X Sanz
INTRODUCTION: Reliable data on DCIS incidence and management are not available in many countries. The present study describes the management of DCIS in Catalonia, Spain in the year 2005 and compares these findings to data obtained in France. Local recurrence and late toxicity rates from 2005 through the end of 2014 are reported. MATERIALS AND METHODS: Observational survey of patients with pure DCIS (n = 270) diagnosed during 2005. A written questionnaire, the same as used in the French survey, was completed by 14 doctors at 12 cancer centres in Catalonia, Spain...
August 11, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28806416/the-impact-of-malignant-nipple-discharge-cytology-ndc-in-surgical-management-of-breast-cancer-patients
#12
Isabella Castellano, Jasna Metovic, Davide Balmativola, Laura Annaratone, Nelson Rangel, Elena Vissio, Riccardo Arisio, Luigia Macrì, Carla Pecchioni, Ivana Sarotto, Francesca Montarolo, Francesca Muscarà, Caterina Marchiò, Paola Cassoni, Janina Kulka, Anna Sapino
BACKGROUND: The role of nipple discharge cytology (NDc) in the surgical management of breast cancer patients is unclear. We aimed: (i) to evaluate the effect of malignant NDc on the surgical approach to the nipple-areola complex, and (ii) to verify the association between malignant NDc and nipple malignancy. METHODS: We retrospectively analyzed a case series of 139 patients with NDc who underwent breast surgery. The clinical and histological findings, types of surgery with emphasis on nipple-areola complex amputation, immunohistochemical phenotypes of the carcinomas and measurements of the tumor-nipple distance were recorded...
2017: PloS One
https://www.readbyqxmd.com/read/28806320/the-value-of-quality-assured-magnetic-resonance-imaging-of-the-breast-for-the-early-detection-of-breast-cancer-in-asymptomatic-women
#13
Uwe Fischer, Susanne Luftner-Nagel, Friedemann Baum, Katharina Marten-Engelke, Susanne Wienbeck
PURPOSE: The aim of this study was to evaluate the exclusive performance of quality-assured high-resolution breast magnetic resonance imaging (MRI) for early detection of breast cancer in a population of asymptomatic women. MATERIALS AND METHODS: A total of 1189 MRI examinations performed in 789 asymptomatic women (mean age, 51.1 years) were evaluated. All examinations were performed using open bilateral surface coil, dedicated compression device, and high spatial resolution (matrix, 512 × 512)...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28801821/-optimal-margins-for-breast-conserving-surgery-with-whole-breast-irradiation-in-ductal-carcinoma-in-situ-results-of-the-astro-asco-and-sso-consensus-guideline
#14
Rainer Souchon
No abstract text is available yet for this article.
August 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28801774/bcl-2-antigen-expression-in-luminal-a-and-triple-negative-breast-cancer
#15
Carla Solange Escórcio-Dourado, Luana Mota Martins, Camila Maria Simplício-Revoredo, Fabiane Araújo Sampaio, Cléciton Braga Tavares, João Paulo da Silva-Sampaio, Umbelina Soares Borges, Francisco Adelton Alves-Ribeiro, Pedro Vitor Lopes-Costa, José Charles Lima-Dourado, Benedito Borges da Silva
Biomarkers for the prognosis of breast cancer have been routinely used in clinical practice, including the expression of hormone receptors, Ki-67 and HER-2. More recently, Bcl-2 has been recognized as an important prognostic factor in breast cancer, although controversies persist with respect to the significance of its expression. The aim of the present study was to evaluate Bcl-2 antigen expression in luminal A and triple-negative breast cancer. Sixty women with invasive ductal carcinoma were included in the study and divided into two groups: Group A (luminal A) and Group B (triple-negative), with 30 cases in each group...
August 11, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28799130/near-set-based-mucin-segmentation-in-histopathology-images-for-detecting-mucinous-carcinoma
#16
Soma Banerjee, Monjoy Saha, Indu Arun, Bijan Basak, Sanjit Agarwal, Rosina Ahmed, Sanjoy Chatterjee, Lipi B Mahanta, Chandan Chakraborty
This paper introducesnear-set based segmentation method for extraction and quantification of mucin regions for detecting mucinouscarcinoma (MC which is a sub type of Invasive ductal carcinoma (IDC)). From histology point of view, the presence of mucin is one of the indicators for detection of this carcinoma. In order to detect MC, the proposed method majorly includes pre-processing by colour correction, colour transformation followed by near-set based segmentation and post-processing for delineating only mucin regions from the histological images at 40×...
August 10, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28797765/patterns-of-fractionation-and-boost-usage-in-adjuvant-external-beam-radiotherapy-for-ductal-carcinoma-in-situ-in-the-united-states
#17
William A Stokes, Arya Amini, Matthew W Jackson, S Reed Plimpton, Nicole Kounalakis, Peter Kabos, Rachel A Rabinovitch, Chad G Rusthoven, Christine M Fisher
BACKGROUND: While the roles of hypofractionated (HFxn) radiotherapy and lumpectomy boost in the adjuvant management of invasive breast cancer are supported by the results of clinical trials, randomized data supporting their use for ductal carcinoma in situ (DCIS) are forthcoming. We sought to evaluate current national trends and identify factors associated with HFxn and boost usage using the National Cancer Database. PATIENTS AND METHODS: We queried the National Cancer Database for women diagnosed with DCIS from 2004 to 2014 undergoing external beam radiotherapy after breast conservation surgery...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28795470/dmkn-contributes-to-the-epithelial-mesenchymal-transition-through-increased-activation-of-stat3-in-pancreatic-cancer
#18
Chaohao Huang, Yukai Xiang, Shengchuan Chen, Huajun Yu, Zhengde Wen, Tingting Ye, Hongwei Sun, Hongru Kong, Dapei Li, Dinglai Yu, Bicheng Chen, Mengtao Zhou
DMKN was first identified in relation to skin lesion healing and skin carcinoma. Recently, its expression has been associated with pancreatic cancer tumorigenesis, although its involvement remains poorly understood. Herein, we show that DMKN loss of function in Patu-8988 and PANC-1 pancreatic cancer cell lines results in reduced phosphorylation of signal transducer and activator of transcription-3 (STAT3), and increased activation of extracellular signal-regulated kinase (ERK1/2) and AKT serine/threonine kinase...
August 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/28795370/surgical-upstaging-rates-for-vacuum-assisted-biopsy-proven-dcis-implications-for-active-surveillance-trials
#19
Lars J Grimm, Marc D Ryser, Ann H Partridge, Alastair M Thompson, Jeremy S Thomas, Jelle Wesseling, E Shelley Hwang
PURPOSE: This study was designed to determine invasive cancer upstaging rates at surgical excision following vacuum-assisted biopsy of ductal carcinoma in situ (DCIS) among women meeting eligibility for active surveillance trials. METHODS: Patients with vacuum-assisted, biopsy-proven DCIS at a single center from 2008 to 2015 were retrospectively reviewed. Imaging and pathology reports were interrogated for the imaging appearance, tumor grade, hormone receptor status, and presence of comedonecrosis...
August 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28791843/ductal-carcinomas-in-situ-and-invasive-cancers-detected-on-screening-mammography-cost-effectiveness-of-initial-and-subsequent-rounds-of-population-based-program-2007-2014
#20
Bartłomiej Szynglarewicz, Rafał Matkowski
BACKGROUND: Potential benefits of screening need to be carefully balanced against the financial burden for the national health care system. OBJECTIVES: To assess the cost-effectiveness of population-based mammographic screening in the 3-million region of Lower Silesia (Poland) after initial and 3 subsequent rounds. MATERIAL AND METHODS: Data was collected in a prospective manner using the databases of the official computer system for the monitoring of prophylaxis programs (SIMP), National Health Fund (Lower Silesia Regional Branch) and the Lower Silesia Cancer Registry...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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