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https://www.readbyqxmd.com/read/29456844/an-efficient-biomarker-panel-for-diagnosis-of-breast-cancer-using-surface-enhanced-laser-desorption-ionization-time-of-flight-mass-spectrometry
#1
Turkan Yigitbasi, Gizem Calibasi-Kocal, Nihal Buyukuslu, Murat Kemal Atahan, Hakan Kupeli, Seyran Yigit, Ercument Tarcan, Yasemin Baskin
Breast cancer (BC) is the most frequently diagnosed cancer that affects women worldwide. Early detection of BC is important to improve survival rates and decrease mortality. The aim of the present study was to investigate serum biomarkers using surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to distinguish patients with BC from the healthy population and patients with benign breast diseases (BBDs). A total of 62 patients with invasive ductal carcinoma, as confirmed by histopathology, and 47 non-cancerous individuals (NCIs) [16 healthy controls (HCs) and 31 patients with BBD] were enrolled in the present study...
March 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29456656/comparison-of-the-diagnostic-efficacy-between-ultrasound-elastography-and-magnetic-resonance-imaging-for-breast-masses
#2
Rong Cheng, Jing Li, Li Ji, Huining Liu, Limin Zhu
The present study compared the efficacy of ultrasound elastography (UE), magnetic resonance imaging (MRI) and the combination of the two methods (UE+MRI) in the differential diagnosis of benign and malignant breast tumors. In total, 86 patients with breast masses were recruited and evaluated by UE, MRI and UE+MRI. Strain ratios of UE were calculated for the breast mass and adjacent normal tissues. In addition, the receiver operating characteristic (ROC) curve was obtained, while the sensitivity and specificity were calculated to determine the optimal cut-off point for the differential diagnosis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29453385/prediction-of-advanced-axillary-lymph-node-metastases-ypn2-3-using-breast-mr-imaging-and-pet-ct-after-neoadjuvant-chemotherapy-in-invasive-ductal-carcinoma-patients
#3
Won Hwa Kim, Sang-Woo Lee, Hye Jung Kim, Yee Soo Chae, Shin Young Jeong, Jin Hyang Jung, Ho Yong Park, Won Kee Lee
We aimed to investigate the value of breast magnetic resonance (MR) imaging and positron emission tomography-computed tomography (PET/CT) in predicting advanced axillary lymph node (ALN) metastases (ypN2-3) after neoadjuvant chemotherapy (NAC) in invasive ductal carcinoma patients. A total of 108 patients with invasive ductal carcinoma underwent breast MR imaging and PET/CT both before and after NAC (termed initial staging and restaging, respectively). The number of positive ALNs and the short diameter (SD) of the largest ALN on breast MR imaging and maximal standardized uptake value (SUVmax) in the ALNs on PET/CT were evaluated...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452147/combination-of-kras-activation-and-pten-deletion-contributes-to-murine-hepatopancreatic-ductal-malignancy
#4
Yun-Kai Lin, Zheng Fang, Tian-Yi Jiang, Zheng-Hua Wan, Yu-Fei Pan, Yun-Han Ma, Yuan-Yuan Shi, Ye-Xiong Tan, Li-Wei Dong, Yong-Jie Zhang, Hong-Yang Wang
Kras mutations are among the most common genetic abnormalities in human neoplasms, including cholangiocarcinomas, pancreatic cancer and colon cancer. PTEN has previously been associated with cholangiocarcinoma development in murine models. Here, we have established novel mouse models of neoplasms by liver-specific and biliary-pancreatic Kras activation and PTEN deletion. By liver-specific disruption of PTEN and activation of Kras in mice caused rapid development of intrahepatic biliary epithelial proliferative lesions (Intrahepatic cholangiocarcinoma, ICC), which progress through dysplasia to invasive carcinoma...
February 13, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29451396/vacuum-assisted-breast-biopsy-vab-excision-of-subcentimeter-microcalcifications-as-an-alternative-to-open-biopsy-for-atypical-ductal-hyperplasia
#5
Schiaffino Simone, Massone Elena, Gristina Licia, Fregatti Piero, Rescinito Giuseppe, Alessandro Villa, Friedman Daniele, Calabrese Massimo
OBJECTIVE: To report the results of the conservative management with mammographic checks of patients with ADH diagnosed by vacuum assisted breast biopsy (VAB), without residual calcifications. METHODS: The authors accessed the institutional database of radiological, surgical and pathologic anatomy. Inclusion criteria were: ADH diagnosed by VAB on a single group of microcalcifications, without residual post-procedure; follow-up at least of 12 months. Exclusion criteria were the presence of personal history of breast cancer or other high risk lesions; association with other synchronous lesions, both more and less advanced proliferative lesions...
February 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29445939/a-comparison-of-two-models-for-breast-cancer-mortality-for-women-with-ductal-carcinoma-in-situ-an-seer-based-analysis
#6
Vasily Giannakeas, Victoria Sopik, Steven A Narod
BACKGROUND: Approximately 1% of patients with ductal carcinoma in situ (DCIS) will die of breast cancer within 10 years. Women who develop an invasive breast cancer after DCIS have a much greater risk of dying than those who do not and it is often stated that these deaths are a consequence of metastases from the invasive in-breast recurrence. This progression is the result of a two-step process: first local invasive recurrence and then spread beyond the breast. A large proportion of women who die of DCIS have no record of invasive recurrence...
February 14, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29445299/choosing-wisely-after-publication-of-level-i-evidence-in-breast-cancer-radiotherapy
#7
Joshua R Niska, Sameer R Keole, Barbara A Pockaj, Michele Y Halyard, Samir H Patel, Donald W Northfelt, Richard J Gray, Nabil Wasif, Carlos E Vargas, William W Wong
Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Based on this evidence, in 2013, the American Society for Radiation Oncology (ASTRO) recommended hypofractionated schedules for women aged ≥50 years with early-stage breast cancer and avoiding routine use of IMRT for WBRT...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29442219/a-case-of-mixed-adenoneuroendocrine-carcinoma-of-the-pancreas-mimicking-intraductal-papillary-mucinous-carcinoma
#8
Hideki Mori, Keiji Hanada, Tomoyuki Minami, Shigeki Yano, Motomitsu Fukuhara, Hirotsugu Maruyama, Akinori Shimizu, Naomichi Hirano, Fumiaki Hino, Hironobu Amano, Shuji Yonehara
A previously healthy 52-year-old man was referred to our hospital for further evaluation of main pancreatic duct dilatation. The preoperative work-up was consistent with intraductal papillary mucinous carcinoma (IPMC) derived from a mixed type intraductal papillary mucinous neoplasm (IPMN), because multilocular cysts with enhancing thickened pancreatic head walls and dilated pancreatic ducts lined with dysplastic mucinous epithelium, with papillary proliferation from the pancreatic body to the tail, were observed; in addition, the pancreatic juice cytology was class V, which is suggestive of adenocarcinoma...
February 13, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29441334/the-usefulness-of-fluorodeoxyglucose-pet-ct-for-preoperative-evaluation-of-ductal-carcinoma-in-situ
#9
Sungchul Kim, Seokjae Lee, Sangwon Kim, Seokmo Lee, Hayong Yum
Purpose: PET/CT is useful in preoperative evaluation of invasive breast cancer (IBC) to predict axillary metastasis and staging workup. The usefulness is unclear in cases of ductal carcinoma in situ (DCIS) diagnosed at biopsy before surgery, which sometimes is upgraded to IBC after definitive surgery. The aim of this study is to find out the usefulness of PET/CT on DCIS as a preoperative evaluation tool. Methods: We investigated 102 patients preoperatively diagnosed with DCIS who subsequently underwent definitive surgery between 2010 and 2015...
February 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29439886/patient-experiences-and-clinician-views-on-the-role-of-radiation-therapy-for-ductal-carcinoma-in-situ
#10
Dean A Shumway, Chandler M McLeod, Monica Morrow, Yun Li, Allison W Kurian, Aaron Sabolch, Ann S Hamilton, Kevin C Ward, Steven J Katz, Sarah T Hawley, Reshma Jagsi
PURPOSE: To evaluate patient experiences with decisions regarding radiation therapy (RT) for ductal carcinoma in situ (DCIS), and to assess clinician views on the role of RT for DCIS with favorable features in the present era. METHODS AND MATERIALS: A sample of women with newly diagnosed breast cancer from the population-based Georgia and Los Angeles County Surveillance, Epidemiology, and End Results (SEER) registries were sent surveys approximately 2 months after undergoing breast-conserving surgery (BCS), with a 70% response rate...
January 9, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29439832/factors-associated-with-positive-margins-in-women-undergoing-breast-conservation-surgery
#11
Brittany L Murphy, Judy C Boughey, Michael G Keeney, Amy E Glasgow, Jennifer M Racz, Gary L Keeney, Elizabeth B Habermann
OBJECTIVE: To identify factors predicting positive margins at lumpectomy prompting intraoperative reexcision in patients with breast cancer treated at a large referral center. PATIENTS AND METHODS: We reviewed all breast cancer lumpectomy cases managed at our institution from January 1, 2012, through December 31, 2013. Associations between rates of positive margin and patient and tumor factors were assessed using χ 2 tests and univariate and adjusted multivariate logistic regression, stratified by ductal carcinoma in situ (DCIS) or invasive cancer...
February 10, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29436376/breast-carcinoma-in-sclerosing-adenosis-a-clinicopathological-and-immunophenotypical-analysis-on-206-lesions
#12
Bao-Hua Yu, Shao-Xian Tang, Xiao-Li Xu, Yu-Fan Cheng, Rui Bi, Ruo-Hong Shui, Xiao-Yu Tu, Hong-Fen Lu, Xiao-Yan Zhou, Wen-Tao Yang
AIMS: To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC). METHODS: Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed. RESULTS: Overall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not...
February 7, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29435853/do-patients-whose-tumor-achieved-a-pathological-response-relapse-at-specific-sites-a-substudy-of-the-eortc-10994-big-1-00-trial
#13
Kim C Aalders, Nathan Touati, Konstantinos Tryfonidis, Mylène Annonay, Saskia Litiere, Jonas Bergh, Alexandre Bodmer, David A Cameron, Hervé R Bonnefoi
PURPOSE: To determine the sites of first distant relapse in patients with or without pCR following neoadjuvant chemotherapy in breast cancer patients enrolled in the EORTC 10994/BIG-1-00 trial. METHODS: We included patients enrolled in the EORTC 10994/BIG-1-00 trial who received at least one chemotherapy cycle before surgery and who had been diagnosed with a distant relapse. pCR was defined as no evidence of residual invasive cancer in the primary tumor and axillary lymph nodes with or without residual ductal carcinoma in situ...
February 12, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29435556/breast-biopsy-intensity-and-findings-following-breast-cancer-screening-in-women-with-and-without-a-personal-history-of-breast-cancer
#14
Diana S M Buist, Linn Abraham, Christoph I Lee, Janie M Lee, Constance Lehman, Ellen S O'Meara, Natasha K Stout, Louise M Henderson, Deirdre Hill, Karen J Wernli, Jennifer S Haas, Anna N A Tosteson, Karla Kerlikowske, Tracy Onega
Importance: There is little evidence on population-based harms and benefits of screening breast magnetic resonance imaging (MRI) in women with and without a personal history of breast cancer (PHBC). Objective: To evaluate biopsy rates and yield in the 90 days following screening (mammography vs magnetic resonance imaging with or without mammography) among women with and without a PHBC. Design, Setting, and Participants: Observational cohort study of 6 Breast Cancer Surveillance Consortium (BCSC) registries...
February 12, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29434878/progesterone-impairs-herceptin-effect-on-breast-cancer-cells
#15
Kamila Kitowska, Agnieszka Kowalska, Magdalena Mieszkowska, Dominika Piasecka, Andrzej C Skladanowski, Hanna M Romanska, Rafal Sadej
Breast cancer (BCa) is the most common cancer affecting women worldwide. Overexpression of human epidermal growth factor receptor 2 (HER2) occurs in ~20-25% of invasive ductal breast carcinomas and is associated with the more aggressive phenotype. Herceptin, a humanized antibody against HER2, is a standard therapy in HER2-overexpressing cases. Approximately one-third of patients relapse despite treatment. Therefore numerous studies have investigated the molecular mechanisms associated with Herceptin resistance...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433879/expression-of-neuropeptide-y-and-its-receptors-y1-and-y2-in-pancreatic-intraepithelial-neoplasia-and-invasive-pancreatic-cancer-in-a-transgenic-mouse-model-and-human-samples-of-pancreatic-cancer
#16
Jens Waldmann, Volker Fendrich, Martin Reichert, Andreas Hecker, Detlef K Bartsch, Winfried Padberg, Julia P N Holler
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is among the most dismal of human malignancies. Neuropeptides have shown to be implicated in angiogenesis, tumor growth, and formation of distant metastases in various solid tumors. In the present study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the impact of neuropeptide Y (NPY) and its receptors 1 (Y1) and 2 (Y2) in preneoplastic lesions and pancreatic cancer as a potential target with antiproliferative properties...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433670/genistein-induced-anticancer-effects-on-pancreatic-cancer-cell-lines-involves-mitochondrial-apoptosis-g-0-g-1-cell-cycle-arrest-and-regulation-of-stat3-signalling-pathway
#17
Yi-Liang Bi, Min Min, Wei Shen, Yan Liu
BACKGROUND: Genistein is a natural flavonoid that has been reported to exhibit anticancer effects against different types of cancers which include, but are not limited to, breast and oral squamous cell carcinoma. PURPOSE: The present study was designed to evaluate the anticancer effects of the natural flavonoid genistein against pancreatic cancer cell lines and to explore the underlying mechanism. METHODS: Antiproliferative activity was investigated by MTT assay...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29432428/plac1-as-a-serum-biomarker-for-breast-cancer
#18
Hongyan Yuan, Vincent Chen, Marc Boisvert, Claudine Isaacs, Robert I Glazer
Placental-specific protein 1 (PLAC1) is an X-linked trophoblast gene that is re-expressed in several malignancies, including breast cancer, and is therefore a potential biomarker to follow disease onset and progression. Sera from 117 preoperative/pretreatment breast cancer patients and 51 control subjects, including those with fibrocystic disease, were analyzed for the presence of PLAC1 protein as well as its expression by IHC in tumor biopsies in a subset of subjects. Serum PLAC1 levels exceeded the mean plus one standard deviation (mean+SD) of the level in control subjects in 67% of subjects with ductal carcinoma in situ (DCIS), 67% with HER2+ tumors, 73% with triple-negative cancer and 73% with ER+/PR+ tumors...
2018: PloS One
https://www.readbyqxmd.com/read/29431468/nipple-invasive-primary-carcinomas-clinical-imaging-and-pathologic-features-of-breast-carcinomas-originating-in-the-nipple
#19
Mary Ann Sanders, Jane E Brock, Beth T Harrison, Tad J Wieczorek, Xuefei Hong, Anthony J Guidi, Deborah A Dillon, Leslie Max, Susan C Lester
CONTEXT: - Patients choosing to retain the nipple when undergoing therapeutic or prophylactic mastectomy are at risk for cancers arising at that site. OBJECTIVE: - To identify cases of invasive carcinoma arising within the nipple and to investigate their clinical, imaging, biologic, and staging features. DESIGN: - Carcinomas were identified by prospective review of surgical and consult cases at 4 hospitals. RESULTS: - The 24 patients identified presented with symptoms related to the nipple...
February 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29430168/assessment-of-p16-expression-and-hpv-infection-in-adenoid-cystic-carcinoma-of-the-lacrimal-gland
#20
Yuchuan Wang, Yuan Tian, Jinyong Lin, Luxia Chen, Liming Wang, Peng Hao, Ruifang Han, Ming Ying, Xuan Li, Xin Tang
Purpose: Adenoid cystic carcinoma (ACC) in the lacrimal gland is a rare malignancy. P16 is encoded by the CDKN2A gene, which is recognized as a tumor suppressor due to its inactivation in many types of tumors. However, p16 overexpression is also linked to adverse tumor parameters. These contradictory observations have also been confirmed in ACCs in the salivary glands. Furthermore, evidence of human papilloma virus (HPV) infection is found in a proportion of ACCs in the salivary glands...
2018: Molecular Vision
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