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https://www.readbyqxmd.com/read/29777629/mechanisms-of-metformin-action-in-and-out-of-the-gut
#1
EDITORIAL
Takahiro Minamii, Munenobu Nogami, Wataru Ogawa
One hundred years have passed since guanidine, a precursor compound of biguanides and thus of metformin, was found to have a glucose-lowering effect in live animals1 . In this historical study, C. K. Watanabe1 did not set out to identify glucose-lowering agents but rather to understand the mechanism underlying the development of tetany in animals that have undergone parathyroidectomy. Watanabe 1 concluded that guanidine is a pathogenic factor responsible for tetany because its administration in rabbits resulted in "tetany-like" muscle cramps associated with low blood glucose levels...
May 19, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29775120/successful-improvement-of-pain-symptomatology-in-a-suspected-case-of-cramp-fasciculation-syndrome-via-interventional-pain-treatment
#2
Anita Gupta, Lucas First, Celeste A Swain
Peripheral nerve hyperexcitability (PNH) syndromes are a rare set of neuromuscular disorders that include cramp-fasciculation syndrome (CFS) and Isaacs syndrome (IS). Successful treatment of these diseases has been achieved with antiepileptic medications; however, chronic pain symptoms can persist. We provide a case report of a 25-year-old female who has suffered from painful severe muscle spasms and fasciculations since childhood. With CFS as our working diagnosis, a treatment regimen using interventional pain techniques, including sympathetic chain blocks, ketamine infusions, and trigger point injections, resulted in a significant decrease in the patient's chronic pain symptoms...
May 18, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29774156/pilot-study-of-orphenadrine-as-a-novel-treatment-for-muscle-cramps-in-patients-with-liver-cirrhosis
#3
Sherief Abd-Elsalam, Ferial El-Kalla, Lobna A Ali, Samah Mosaad, Walaa Alkhalawany, Berihan Elemary, Rehab Badawi, Asmaa Elzeftawy, Amr Hanafy, Asem Elfert
Background and aims: Muscle cramps markedly affect the quality of life in cirrhotic patients with no available highly effective treatment. The aim of this study was to assess the safety and efficacy of orphenadrine in the treatment of muscle cramps in cirrhotic patients. Methods: The study enrolled 30 liver cirrhosis patients complaining of frequent muscle cramps (≥3 per week), who were randomized to receive either orphenadrine 100 mg or calcium carbonate 500 mg twice daily as a control for one month...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29733841/abdominal-skeletal-muscle-activity-precedes-spontaneous-menstrual-cramping-pain-in-primary-dysmenorrhea
#4
Folabomi A Oladosu, Frank F Tu, Saaniya Farhan, Ellen F Garrison, Nicole D Steiner, Genevieve E Roth, Kevin M Hellman
BACKGROUND: Dysmenorrhea is a pervasive pain condition that affects 20-50% of reproductive-aged women. Distension of a visceral organ, such as the uterus, could elicit a viscero-motor reflex resulting in involuntary skeletal muscle activity and referred pain. Although referred abdominal pain mechanisms can contribute to visceral pain, the role of abdominal muscle activity has not yet been investigated within the context of menstrual pain. OBJECTIVE: The goal of this study is to determine if involuntary abdominal muscle activity precedes spontaneous episodes of menstrual cramping pain in dysmenorrheic women and if naproxen administration affects abdominal muscle activity...
May 4, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29670481/exercise-associated-muscle-cramp-doubts-about-the-cause
#5
Dzenan Jahic, Edin Begic
Introduction: Exercise-associated muscle cramp (EAMC) is one of the most common conditions that occur during or immediately after the exercise, with questionable etiology. Aim: Aim of article was to present doubts about the cause of EAMC, whether it is primarily a neurological condition or it is water and salt imbalance. Results: Strongest evidence supports the neuromuscular aetiology with the focus on the muscle fatigue. Muscle overload and fatigue affects the balance between the excitatory drive from muscle spindles and the inhibitory drive from the Golgi tendon organs (GTO)...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29660929/ecchymosis-a-novel-sign-in-patients-with-varicose-veins
#6
Ertan Yetkin, Mehmet Ileri, Johannes Waltenberger
BACKGROUND: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein. MATERIALS AND METHODS: Four hundred and ninety four patients who had been diagnosed as having varicose vein or chronic venous insufficiency either by clinical examination or Doppler ultrasonography were included in the study...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29596010/whole-body-vibration-on-people-with-sequelae-of-polio
#7
Carolyn P Da Silva, C Lauren Szot, Natasha deSa
PURPOSE: The purpose was to explore the feasibility of whole body vibration (WBV) on polio survivors with/without post-polio syndrome (PPS) by studying its effects on walking speed (10-m walk test), endurance (2-min walk test), pain severity/interference (Brief Pain Inventory [BPI]), sleep quality (Pittsburg Sleep Quality Index), fatigue (Fatigue Severity Scale), leg strength (manual muscle testing and hand-held dynamometry), and muscle cramping (written logs). METHODS: Fifteen individuals completed the study, participating in eight sessions in two 4-week blocks...
March 29, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29590409/motor-unit-number-estimate-and-isometric-hand-grip-strength-in-military-veterans-with-or-without-muscular-complaints-reference-values-for-longitudinal-follow-up
#8
Mian Li, Wenguo Yao, Cynthia Sundahl
Introduction: It remains unclear if Gulf War (GW) veterans have a higher risk of developing motor neuron disorder. We intended to establish baseline neurophysiological values, including thenar motor unit number estimate (MUNE) and isometric hand grip (IHG) strength, to compare future follow-ups of deployed GW veterans with or without muscular complaints. Materials and Methods: We evaluated 19 GW veterans with self-reported weakness, cramps, or excessive muscle fatigue (Ill-19) and compared them with 18 controls without such muscular complaints (C-18)...
March 26, 2018: Military Medicine
https://www.readbyqxmd.com/read/29582541/relationship-of-muscle-cramps-to-quality-of-life-and-sleep-disturbance-in-patients-with-chronic-liver-diseases-a-nationwide-study
#9
Motoh Iwasa, Yoshiyasu Karino, Takumi Kawaguchi, Hiroyuki Nakanishi, Hisamitsu Miyaaki, Makoto Shiraki, Tomoaki Nakajima, Yasuhiko Sawada, Hitoshi Yoshiji, Kiwamu Okita, Kazuhiko Koike
BACKGROUND & AIMS: Although muscle cramps frequently occur in patients with cirrhosis, the importance of muscle cramps remains unclear. The aims of this study were to investigate the relationship of muscle cramps with quality of life (QOL) and sleep disturbance. In addition, this multi-institutional collaborative study in Japan investigated factors associated with muscle cramps in patients with cirrhosis. METHODS: A total of 1,788 patients with chronic liver diseases including both non-cirrhosis and cirrhosis completed a questionnaire survey investigating: i) frequency of muscle cramps, ii) relationship of muscle cramps to poor QOL and sleep disturbance, iii) characteristics of patients who require therapeutic intervention, and iv) characteristics of patients prone to experiencing muscle cramps...
March 27, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29581918/steroids-and-thyrotoxicosis-precipitate-periodic-paralysis
#10
Rizwan Ahamed, Sarah McCalley, Anupam A Sule
Thyrotoxic Periodic Paralysis (TPP) belongs to a group of muscle diseases called channelopathies, which present with painless generalized muscle weakness without exertion. TPP can be precipitated by a large carbohydrate meal, stress, strenuous exercise, alcohol, a high-salt diet, menstruation, and cold temperatures. Rarely, steroids such as dexamethasone can also precipitate a TPP attack. A 29-year-old Hispanic male, with a history of hyperthyroidism, presented to the emergency department with progressive weakness, predominantly in the lower extremities since morning...
January 23, 2018: Curēus
https://www.readbyqxmd.com/read/29577553/metformin-s-impact-on-statin-associated-muscle-symptoms-an-analysis-of-accord-study-data-and-research-materials-from-the-nhlbi-biologic-specimen-and-data-repository-information-coordinating-center
#11
Nicholas W Carris, Athanasios Tsalatsanis, Srinivas M Tipparaju, Feng Cheng, Ronald R Magness, Ambuj Kumar
Statins are widely prescribed, yet statin muscle pain limits use, leading to increased cardiovascular risk. No validated therapy for statin muscle pain exists. The goal of the study was to assess if metformin was associated with reduced muscle pain. A secondary analysis of data from the ACCORD trial was performed. An ACCORD sub-study assessed patients for muscle cramps and leg/calve pain while walking, typical non-severe statin muscle pain symptoms. We compared muscle pain between patients taking a statin (n = 445) or a statin and metformin (n = 869) at baseline...
March 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29576359/correlation-of-symptoms-to-serum-vitamin-d-levels
#12
Mir Sadat-Ali, Omar N Al Essa, Fawaz M Alani, Hussain K Al Omar, Walid Y Ebrahim
BACKGROUND AND OBJECTIVE: Recent studies have shown that vitamin D plays an important role in many disease processes. However, data is lacking which correlates the common symptoms attributed with vitamin D levels. This study was undertaken to find the correlation of symptoms and Vitamin D levels among ethnic Saudi Arabian population. METHODS: A structured questionnaire was made and translated in the Arabic language, which included, age, weight and height, ethnicity and marital status...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29572370/two-cases-of-hypokalaemic-rhabdomyolysis-same-but-different
#13
Philipp Pecnik, Petra Müller, Sybille Vrabel, Martin Windpessl
In this paper, we present two women with hypokalaemic rhabdomyolysis in the context of increased diuretic intake and gastroenteritis, respectively. While their clinical manifestations and laboratory results were strikingly similar, two different underlying disorders were subsequently unveiled. The first patient was diagnosed with Conn syndrome, and adrenalectomy led to significant improvement of hypertension and sustained normokalaemia. The diagnosis in the second patient was Gitelman syndrome. Electrolyte supplements improved long-term lassitude and the frequency of muscle cramps declined significantly...
March 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29560763/pre-and-peripartal-management-of-a-woman-with-mcardle-disease-a-case-report
#14
Tina Stopp, Michael Feichtinger, Wolfgang Eppel, Thomas M Stulnig, Peter Husslein, Christian Göbl
McArdle disease or glycogen storage disease (GSD) type V is a rare autosomal recessive inherited disorder in skeletal muscle metabolism leading to exercise intolerance, muscle cramps and in some cases to rhabdomyolysis and acute renal failure due to elevated serum myoglobin levels. Albeit the uterine smooth muscle is not affected, pregnancy and delivery can be physically strenuous and may require specific anesthesiologic care. However, data on pregnancy progress and outcome and on special implications linked to anesthesia in women with McArdle's disease is scarce, thus posing a challenge to pre- and peripartal management...
March 21, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29559445/symptom-prioritization-among-adults-receiving-in-center-hemodialysis-a-mixed-methods-study
#15
Jennifer E Flythe, Tandrea Hilliard, Graciela Castillo, Kourtney Ikeler, Jazmine Orazi, Emaad Abdel-Rahman, Amy Barton Pai, Matthew B Rivara, Wendy L St Peter, Steven D Weisbord, Caroline Wilkie, Rajnish Mehrotra
BACKGROUND AND OBJECTIVES: Individuals receiving in-center hemodialysis experience a high symptom burden that detrimentally affects their quality of life. There are few evidence-based interventions for symptom relief in this population. To stimulate innovation in symptom management, data on patient symptom prioritization and treatment preferences are needed. We undertook this study to ( 1 ) identify patient-prioritized symptoms for the development of symptom relief therapies and ( 2 ) elicit preferences for treatments among individuals receiving hemodialysis...
March 20, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29531726/novel-myophosphorylase-mutation-p-arg94pro-with-progressive-exercise-intolerance
#16
Maryam Nabavi Nouri, Anne-Marie Lamhonwah, Ingrid Tein
We present a 16-year-old girl with a unique clinical phenotype characterized by rapidly progressive exercise intolerance, transient exertional weakness, and progressive muscle cramps involving all limbs and bulbar muscles, following a first myoglobinuric episode at age 15 years, arising from homozygosity for a novel missense mutation (c.281G>C) in PYGM .
March 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29515058/effects-of-l-carnitine-supplementation-on-the-quality-of-life-in-diabetic-patients-with-muscle-cramps
#17
Ayumi Imbe, Keiji Tanimoto, Yuiko Inaba, Satoshi Sakai, Kanako Shishikura, Hisashi Imbe, Yoshimi Tanimoto, Jungo Terasaki, Akihisa Imagawa, Toshiaki Hanafusa
Diabetic patients often suffer from muscle cramps. This study aimed to compare the quality of life (QOL) of diabetic patients with and without muscle cramps and to investigate the effect of L-carnitine supplementation in diabetic patients with muscle cramps. A total of 91 patients with diabetes were enrolled in this study: 69 patients with muscle cramps and 22 patients without muscle cramps. Muscle cramps and QOL were evaluated using the muscle cramp questionnaire and the Short Form 36 health survey version 2 (SF-36), respectively...
March 6, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29510461/mexiletine-for-muscle-cramps-in-amyotrophic-lateral-sclerosis-a-randomized-double-blind-crossover-trial
#18
Björn Oskarsson, Dan Moore, Tahseen Mozaffar, John Ravits, Martina Wiedau-Pazos, Nicholas Parziale, Nanette C Joyce, Ross Mandeville, Namita Goyal, Merit E Cudkowicz, Michael Weiss, Robert G Miller, Craig M McDonald
INTRODUCTION: More than 90% of amyotrophic lateral sclerosis (ALS) patients have muscle cramps, but evidence-based treatments have not been available. METHODS: A multicenter, double-blind, placebo-controlled crossover trial of mexiletine 150 mg twice daily was conducted in ALS patients requesting treatment of symptomatic muscle cramps. RESULTS: Muscle cramp frequency was reduced in 18 of 20 patients; 13 reductions were attributed to treatment (P < 0...
March 6, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29482418/physical-therapy-for-nocturnal-lower-limb-cramping-a-case-report
#19
Addison Williams Andrews, Richard Pine
BACKGROUND AND PURPOSE: Nocturnal lower limb cramps are sudden, intensely painful, and can decrease sleep, increase anxiety, and reduce quality of life. The purpose of this case report is to describe the effectiveness of an evidence-based physical therapy intervention for a person with lower limb cramps. CASE DESCRIPTION: The patient was a 34-year-old female who presented with idiopathic bilateral lower limb foot pain and cramps. INTERVENTION: Rehabilitation addressed muscle strength, joint mobility, soft tissue extensibility, and biomechanical influences during functional movement, for a total of seven sessions over seven weeks...
February 26, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29424318/the-significance-of-pain-in-chronic-venous-disease-and-its-medical-treatment
#20
Djordje Radak, Igor Atanasijevic, Mihailo Neskovic, Esma Isenovic
Chronic venous disease (CVeD) is a highly prevalent condition in the general population, and it has a significant impact on quality of life. While it is usually manifested by obvious signs, such as varicose veins and venous ulcers, other symptoms of the disease are less specific. Among the other symptoms, which include heaviness, swelling, muscle cramps and restless legs, pain is the symptom that most frequently compels CVeD patients to seek medical aid. However, there is a substantial discrepancy between pain severity and clinically detectable signs of CVeD, questioned by several opposing studies...
February 8, 2018: Current Vascular Pharmacology
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