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Muscle cramp

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https://www.readbyqxmd.com/read/27911333/the-%C3%A2-strand-ryhming-test-is-not-a-feasible-measure-in-ambulatory-patients-with%C3%A2-amyotrophic-lateral-sclerosis
#1
Annerieke C van Groenestijn, Olaf Verschuren, Carin D Schröder, Leonard H van den Berg, Johanna M A Visser-Meily
BACKGROUND: Ambulatory patients with Amyotrophic Lateral Sclerosis (ALS) show a decreased aerobic capacity which may hamper the ability to perform activities of daily living. A standardized measure, however, for assessing aerobic capacity in patients with ALS during the disease course, is lacking. OBJECTIVE: To examine the feasibility of the Åstrand-Ryhming (ÅR) test protocol longitudinally in ambulatory patients with amyotrophic lateral sclerosis (ALS). METHODS: Seven ambulatory male patients with spinal ALS onset were assessed at baseline and at 4, 7 and 10 months' follow-up...
November 29, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27909678/bridge-tenodesis-a-secure-fixation-technique-for-biceps-long-head-tendinopathy-during-arthroscopic-rotator-cuff-repair-using-a-suture-bridge-technique
#2
Jin-Young Park, Jae-Hyung Lee, Kyung-Soo Oh, Seok-Won Chung, Jin-Young Bang, Young-Min Noh
Tendinopathy of the long head of the biceps is often found as an intra-articular pathology in the glenohumeral joint. Because long head of the biceps lesions are common, surgical intervention to properly manage the long head of the biceps has become an important issue. Both tenodesis and tenotomy have been shown to provide benefits in biceps long head tendinopathy. But because of concerns about muscle power reduction, cramping, and "Popeye's deformity," which may result from biceps tenotomy, biceps tenodesis is a good option for treating biceps lesions...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27909636/imatinib-induced-ototoxicity-in-a-patient-with-gastrointestinal-stromal-tumor-gist
#3
Komal Wasif, Nawal Wasif, Muhammad W Saif
Imatinib (Gleevec) is a biological agent that is approved for the treatment of chronic myeloid leukemia (CML) as well as gastrointestinal stromal tumor (GIST). The most frequently seen adverse effects in patients treated with imatinib include superficial edema, muscle cramps, musculoskeletal pain, rash, fatigue, headache, abdominal pain, and joint pain. Ototoxicity has rarely been reported except in two cases. We report a case of bilateral irreversible sensorineural hearing loss (SNHL) caused by imatinib in a patient receiving this agent in the adjuvant setting...
October 26, 2016: Curēus
https://www.readbyqxmd.com/read/27898361/movement-symptoms-in-european-moyamoya-angiopathy-first-systematic-questionnaire-study
#4
Markus Kraemer, Leonidas Trakolis, Jens Platzen, Jan Claudius Schwitalla, Anna Bersano, Philipp Albrecht, Marc Schlamann, Peter Berlit
OBJECTIVE: Movement disorders are a rare manifestation of Moyamoya angiopathy (MMA). Data on prevalence and clinical presentation are warranted. Possible involuntary movements include focal motor seizures, tremor, limb-shaking transient ischemic attacks, choreiform and spastic or dystonic movement disorders. PATIENTS AND METHODS: We developed a questionnaire to systematically assess movement disorders in MMA. Patients' history of involuntary movements and their clinical presentation were assessed systematically by interview...
November 23, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27878516/axonal-excitability-in-amyotrophic-lateral-sclerosis-axonal-excitability-in-als
#5
REVIEW
Susanna B Park, Matthew C Kiernan, Steve Vucic
Axonal excitability testing provides in vivo assessment of axonal ion channel function and membrane potential. Excitability techniques have provided insights into the pathophysiological mechanisms underlying the development of neurodegeneration and clinical features of amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders. Specifically, abnormalities of Na(+) and K(+) conductances contribute to development of membrane hyperexcitability in ALS, thereby leading to symptom generation of muscle cramps and fasciculations, in addition to promoting a neurodegenerative cascade via Ca(2+)-mediated processes...
November 22, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27866992/comorbidities-that-cause-pain-and-the-contributors-to-pain-in-individuals-with-chronic-obstructive-pulmonary-disease
#6
Yi-Wen Chen, Pat G Camp, Harvey O Coxson, Jeremy D Road, Jordan A Guenette, Michael A Hunt, W Darlene Reid
OBJECTIVE: To determine comorbidities that cause pain and the potential contributors to pain in individuals with COPD. DESIGN: Prospective cross-sectional survey study. SETTING: Pulmonary rehabilitation programs of six centers. PARTICIPANTS: A convenience sample of individuals with COPD who attended pulmonary rehabilitation programs (n=137). In total, 100 (73%) returned the survey packages. Of those responders, 96 (70%) participants were included in the analyses...
November 17, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27861220/hereditary-neuropathy-with-liability-to-pressure-palsies-diverse-phenotypes-in-childhood
#7
Yohei Harada, Araya Puwanant, David N Herrmann
Hereditary neuropathy with liability to pressure palsies (HNPP) is a rare autosomal-dominant disorder that most commonly produces recurrent painless focal sensory and motor neuropathies often preceded by minor, mechanical stress, or minor trauma. Herein, we report 2 pediatric cases of HNPP with atypical presentations; isolated muscle cramping and toe walking. Electrophysiologic testing disclosed multifocal sensorimotor polyneuropathy with slowing of sensory conduction velocities in both cases, which prompted PMP 22 gene deletion testing...
December 2016: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/27854207/long-term-oral-dantrolene-improved-muscular-symptoms-in-a-malignant-hyperthermia-susceptible-individual
#8
Brian N Butala, Audry Kang, Jasmeen Guron, Barbara W Brandom
This case report describes a female with p.Lys4876Arg amino acid change in the ryanodine receptor type 1 (RYR1) and a sibling who died of malignant hyperthermia (MH) during anesthesia. After her diagnosis as MH susceptible, this patient was administered low-dose dantrolene daily for greater than 25 years for treatment of chronic muscle spasm and pain in her lower extremities and back limiting sleep. Her creatine phosphokinase (CPK) was as high as 2390 IU/L during labor and 900 IU at rest. With 25 mg dantrolene daily, muscle cramps were eliminated, and sleep was improved...
March 3, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27793952/new-drug-and-possible-new-toxicity-squamous-cell-carcinoma-following-imatinib-in-patients-with-gastrointestinal-stromal-tumors
#9
Faisal Inayat, Muhammad Wasif Saif
BACKGROUND: Molecularly targeted therapy has revolutionized the treatment of advanced gastrointestinal stromal tumors (GISTs). Specifically, the consistent dependence of GISTs on proto-oncogene c-KIT signaling led to the development and successful implementation of imatinib, a small-molecule c-KIT inhibitor. Imatinib induces, rapid and sustained clinical benefit by blocking the signaling via c-KIT. The most frequently reported adverse reactions (>30%) include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue and abdominal pain...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27777917/adjuvant-teriparatide-therapy-for-surgical-treatment-of-femoral-fractures-does-it-work
#10
Jung Taek Kim, Hyung Jun Jeong, Soong Joon Lee, Hee Joong Kim, Jeong Joon Yoo
PURPOSE: Atypical femoral fracture (AFF), periprosthetic femoral fracture (PPFF) and femoral nonunion (FNU) are recalcitrant challenges for orthopedic surgeons. Teriparatide (TPTD) had been demonstrated to have anabolic effects on bone in various studies. We postulated that adjuvant TPTD after operation would enhance biologic stimulation for bone formation. We investigated (1) whether the adjuvant TPTD could achieve satisfactory union rate of surgically challenging cases such as displaced AFF, PPFF and FNU; (2) whether the adjuvant TPTD could promote development of abundant callus after surgical fixation; (3) whether the adjuvant TPTD had medically serious adverse effects...
September 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/27773588/differences-in-active-range-of-motion-measurements-in-the-upper-extremity-of-patients-with-writer-s-cramp-compared-with-healthy-controls
#11
Prachaya Srivanitchapoom, Ejaz A Shamim, Pierre Diomi, Takaaki Hattori, Sanjay Pandey, Sherry Vorbach, Jung E Park, Tianxia Wu, Sungyoung Auh, Mark Hallett
STUDY DESIGN: Exploratory case-control study. INTRODUCTION: Writer's cramp (WC) is a type of focal hand dystonia. The central nervous system plays a role in its pathophysiology, but abnormalities in the affected musculoskeletal components may also be relevant. PURPOSE OF THE STUDY: We compared the active range of motion (ROM) in patients with WC and healthy volunteers (HVs) and correlated the findings with disease duration and severity. METHODS: Affected limb joints were measured with goniometers...
February 18, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27758157/clinical-significance-of-different-carnitine-levels-for-improving-the-prognosis-of-patients-undergoing-hemodialysis
#12
Yu-Mei Zhang, Li Zhuo, Jing Hu, Gang Cui, Ling Zhang, Xiang-Lin Zhang, Wen-Ge Li
OBJECTIVE: To investigate plasma-free carnitine (Fc), acylcarnitine (Ac), and total carnitine (Tc) levels in patients undergoing hemodialysis (HD), and to explore their clinical significance. METHODS: A total of 20 subjects were in the normal control group and 133 patients undergoing HD were divided into medicated (received carnitine treatment) and non-medicated groups. The medicated group was further divided into three subgroups according to Fc level: Fc = 80-199, 200-299, and ≥ 300 μmol/L...
October 19, 2016: Renal Failure
https://www.readbyqxmd.com/read/27747851/sodium-intake-during-an-ultramarathon-does-not-prevent-muscle-cramping-dehydration-hyponatremia-or-nausea
#13
Martin D Hoffman, Kristin J Stuempfle, Taylor Valentino
BACKGROUND: Ultramarathon runners commonly believe that sodium replacement is important for prevention of muscle cramping, dehydration, hyponatremia, and nausea during prolonged continuous exercise. The purpose of this study was to measure total sodium intake to determine if these beliefs are supported. METHODS: Participants of a 161-km ultramarathon (air temperature reaching 39 °C) provided full dietary information during the race, underwent body weight measurements before and after the race, completed a post-race questionnaire about muscle cramping and nausea or vomiting during the race, and had post-race plasma sodium concentration measured...
December 2015: Sports Medicine—Open
https://www.readbyqxmd.com/read/27735167/gitelman-like-syndrome-with-kanamycin-toxicity
#14
Gouranga Santra, Rudrajit Paul, Avik Karak, Somnath Mukhopadhay
A 22 year-old lady with multi-drug-resistant pulmonary tuberculosis was on Kanamycin, Cycloserine, Ethionamide, Pyrazinamide and Moxifloxacin since more than two months. She presented with muscle cramps and carpopedal spasm. Investigation revealed hypokalemia and metabolic alkalosis. She also had hypomagnesemia, hypochloremia and hypocalciuria. Serum urea and creatinine levels were normal. Patient was treated with intravenous and oral potassium chloride. Kanamycin was stopped. Metabolic alkalosis and hypokalemia improved gradually over one month...
May 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27717598/-statin-associated-myopathy-in-clinical-practice-results-of-dama-study
#15
Jesús Millán, Juan Pedro-Botet, Elisenda Climent, Joaquín Millán, Joan Rius
BACKGROUND AND OBJECTIVE: Muscle symptoms, with or without elevation of creatin kinase are one of the main adverse effects of statin therapy, a fact that sometimes limits their use. The aim of this study was to evaluate the clinical characteristics of patients treated with statins who have complained muscle symptoms and to identify possible predictive factors. PATIENTS AND METHODS: A cross-sectional one-visit, non-interventional, national multicenter study including patients of both sexes over 18 years of age referred for past or present muscle symptoms associated with statin therapy was conducted...
October 4, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27716084/quinine-induced-simvastatin-toxicity-through-cytochrome-inhibition-a-case-report
#16
Johannes M Just, Klaus Weckbecker, Katja S Just
BACKGROUND: Nocturnal leg cramps are painful, involuntary muscle contractions commonly seen in elderly. While mostly harmless, they can severely impair quality of life and often disrupt sleep. Adverse drug effects may be responsible for a fraction of nocturnal leg cramps but often go unrecognized, resulting in additional prescribing intended to deal with adverse effects that might be better addressed by reduction, substitution, or discontinuation of the offending agent. CASE PRESENTATION: An 87 year old female presented as outpatient in family medicine with nocturnal leg cramps which had been present for five years and increasingly burdened her quality of life...
October 1, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27713843/tyrosine-kinase-inhibitors-for-the-treatment-of-chronic-phase-chronic-myeloid-leukemia-long-term-patient-care-and-management
#17
Stephanie Bauer, Susan Buchanan, Irene Ryan
Several tyrosine kinase inhibitors (TKIs) are now approved for the treatment of chronic myeloid leukemia in chronic phase. The efficacy of these drugs has been repeatedly demonstrated, as has their tolerability in most patients. However, late and chronic toxicities become an important issue for many patients facing long-term TKI exposure. For patients on long-term imatinib, gastrointestinal events, fluid retention, muscle cramps, fatigue, and hepatotoxicity are among the most common and most clinically relevant adverse events (AEs)...
January 2016: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/27710151/exertional-hyponatremia-and-serum-sodium-change-during-ultraendurance-cycling
#18
Lawrence E Armstrong, Elaine C Lee, Douglas Casa, Evan C Johnson, Matthew S Ganio, Brendon McDermott, Jakob Vingren, Hymn M Oh, Keith H Williamson
Although case reports of exertional hyponatremia (EH) during prolonged exercise implicate retention of excess fluid, athletes with EH experience either loss, gain, or no change of body weight. Thus, the etiology and predisposing factors of EH may not be the same in all athletes. The present field investigation evaluated two unacquainted recreational cyclists (LC, 31y and AM, 39y) who began exercise with normal serum electrolytes but finished a summer 164-km ride (ambient, 34±5°C) with a serum [Na+] of 130 mmol/L...
October 6, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27676876/muscle-injuries-and-hamstring-muscle-injuries-during-the-international-athletics-championships-between-2007-and-2015
#19
Pascal Edouard, Pedro Branco, Juan-Manuel Alonso
OBJECTIVE: The purpose of this study was to analyse the incidence and characteristics of muscle injuries and hamstring muscle injuries occurred during the international athletics championships from 2007 to 2015. PATIENTS AND METHODS: National medical teams and local organizing committee physicians have collected every day all newly occurred injury whenever international championship from 2007 to 2015. Only the muscle injuries and hamstring muscle injuries, whatever gravity (cramp, contracture, rupture, avulsion), were analysed...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676872/athletic-injury-prevention-epidemiology-of-injuries-during-the-french-elite-championships
#20
Pascal Edouard, Jean-Michel Serra, Pierre Hertert, Emmanuelle Cugy, Nicolas Morel, Martine Prevost, Frédéric Depiesse
OBJECTIVE: The epidemiology of injuries is the first step in the sports injuries prevention. In this context, the IAAF and EA have implemented a prospective injury follow-up during their international athletics championships since 2007, and the FFA initiated since the French championships in 2014. The aim of the study was to determine the incidence and characteristics of injuries during the French Elite championships. PATIENTS AND METHODS: During the period of the outdoor and indoor French Elite championships, all newly occurring injuries were recorded by the local medical team...
September 2016: Annals of Physical and Rehabilitation Medicine
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