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https://www.readbyqxmd.com/read/27936457/genetic-disruption-of-nrf2-promotes-the-development-of-necroinflammation-and-liver-fibrosis-in-a-mouse-model-of-hfe-hereditary-hemochromatosis
#1
Tiago L Duarte, Carolina Caldas, Ana G Santos, Sandro Silva-Gomes, Andreia Santos-Gonçalves, Maria João Martins, Graça Porto, José Manuel Lopes
BACKGROUND AND AIMS: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor NRF2 is a critical determinant of hepatocyte viability during exposure to acute dietary iron overload...
December 1, 2016: Redox Biology
https://www.readbyqxmd.com/read/27936433/carbon-starvation-induces-lipid-degradation-via-autophagy-in-the-model-alga-micrasterias
#2
Viola Schwarz, Ancuela Andosch, Anja Geretschläger, Matthias Affenzeller, Ursula Lütz-Meindl
Autophagy is regarded as crucial intracellular process in plant development but also in intracellular stress response. It is known to be controlled by the energy level of the cell and consequently can be triggered by energy deprivation. In this study carbon starvation evoked in different ways was investigated in the freshwater algae model system Micrasterias denticulata (Streptophyta) which is closely related to higher plants. Cells exposed to the photosynthesis inhibiting herbicide DCMU, to the glycolysis inhibitor 2-Deoxy-d-glucose and to complete darkness over up to 9 weeks for preventing metabolism downstream of glucose supply, were investigated by means of Nile red staining and analyses in CLSM, and TEM after cryo-preparation...
November 24, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/27936403/arsenic-accumulation-and-speciation-in-rice-grown-in-arsanilic-acid-elevated-paddy-soil
#3
Anjing Geng, Xu Wang, Lishu Wu, Fuhua Wang, Yan Chen, Hui Yang, Zhan Zhang, Xiaoli Zhao
P-arsanilic acid (AsA) is a emerging but less concerned contaminant used in animal feeding operations, for it can be degraded to more toxic metabolites after being excreted by animals. Rice is the staple food in many parts of the world, and also more efficient in accumulating arsenic (As) compared to other cereals. However, the uptake and transformation of AsA by rice is unclear. This study aimed to evaluate the potential risk of using AsA as a feed additive and using the AsA contaminated animal manure as a fertilizer...
December 6, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27936318/copper-ii-thymine-coordination-polymer-nanoribbons-as-potential-oligonucleotide-nanocarriers
#4
Verónica G Vegas, Romina Lorca, Ana Latorre, Khaled Hassanein, Carlos J Gómez-García, Oscar Castillo, Álvaro Somoza, Félix Zamora, Pilar Amo-Ochoa
The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4'-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150-185 nm; diameter ca. 15-60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines-despite the copper(II) content-and can be used as nanocarriers of oligonucleotides...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27936311/glucose-responsive-sequential-generation-of-hydrogen-peroxide-and-nitric-oxide-for-synergistic-cancer-starving-like-gas-therapy
#5
Wenpei Fan, Nan Lu, Peng Huang, Yi Liu, Zhen Yang, Sheng Wang, Guocan Yu, Yijing Liu, Junkai Hu, Qianjun He, Junle Qu, Tianfu Wang, Xiaoyuan Chen
Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H2 O2 can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H2 O2 -NO cooperative anticancer effect with minimal adverse effect...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27936304/continuous-flow-synthesis-and-purification-of-aryldiazomethanes-through-hydrazone-fragmentation
#6
Éric Lévesque, Simon T Laporte, André B Charette
Electron-rich diazo compounds, such as aryldiazomethanes, are powerful reagents for the synthesis of complex structures, but the risks associated with their toxicity and instability often limit their use. Flow chemistry techniques make these issues avoidable, as the hazardous intermediate can be used as it is produced, avoiding accumulation and handling. Unfortunately, the produced stream is often contaminated with other reagents and by-products, making it incompatible with many applications, especially in catalysis...
December 9, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27936301/new-furanone-derivatives-and-alkaloids-from-the-co-culture-of-marine-derived-fungi-aspergillus-sclerotiorum-and-penicillium-citrinum
#7
Jie Bao, Jie Wang, Xiao-Yong Zhang, Xu-Hua Nong, Shu-Hua Qi
Six new compounds including two furanone derivatives sclerotiorumins A-B (1-2), one novel oxadiazin derivative sclerotiorumin C (3), one pyrrole derivative 1-(4-benzyl-1H-pyrrol-3-yl)ethanone (4), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin (5) and ferrineohydroxyaspergillin (6) were isolated from the co-culture of marine-derived fungi Aspergillus sclerotiorum and Penicillium citrinum. Compound 3 was the first natural 1,2,4-oxadiazin-6-one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line (IC50 = 4...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936296/antiangiogenic-and-toxic-effects-of-genistein-usnic-acid-and-their-copper-complexes-in-zebrafish-embryos-at-different-developmental-stages
#8
Heidrun Draut, Tobias Rehm, Gerrit Begemann, Rainer Schobert
Angiogenesis plays a major role in the normal embryonic development and in diseases such as cancer. Drugs that control angiogenesis are an alternative way to tackle this disease. The polyphenols usnic acid 3, genistein 5, and daidzein 6 were tested for antiangiogenic and unwanted effects in zebrafish embryos whose blood vessel system resembles that of mammals. The established tyrosine kinase inhibitors axitinib 1 and tyrphostin AG490 2 were included for comparison. All compounds except 6 caused distinct antiangiogenic effects such as a concentration-dependent reduction of intersegmental vessels, dorsal longitudinal anastomotic vessels, subintestinal veins and secondary sprouts...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936281/interindividual-and-interethnic-variability-in-drug-disposition-mt%C3%A2-%C3%A2-polymorphisms-in-organic-anion-transporting-polypeptide-1b1-oatp1b1-slco1b1
#9
REVIEW
Hannah H Lee, Richard H Ho
OATP1B1 (SLCO1B1) is predominantly expressed at the basolateral membrane of hepatocytes and is critically important for the hepatic uptake and clearance of numerous drug substrates and endogenous compounds. In general, the organic anion transporting polypeptides (OATP; SLCO) represent a superfamily of uptake transporters that mediate the sodium-independent transport of a diverse range of amphipathic organic compounds including bile salts, steroid conjugates, thyroid hormones, anionic peptides, numerous drugs and other xenobiotic substances...
December 9, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27936244/gene-expression-and-silencing-studies-in-phytophthora-infestans-reveal-infection-specific-nutrient-transporters-and-a-role-for-the-nitrate-reductase-pathway-in-plant-pathogenesis
#10
Melania Abrahamian, Audrey M V Ah-Fong, Carol Davis, Kalina Andreeva, Howard S Judelson
To help learn how phytopathogens feed from their hosts, genes for nutrient transporters from the hemibiotrophic potato and tomato pest Phytophthora infestans were annotated. This identified 453 genes from 19 families. Comparisons with a necrotrophic oomycete, Pythium ultimum, and a hemibiotrophic fungus, Magnaporthe oryzae, revealed diversity in the size of some families although a similar fraction of genes encoded transporters. RNA-seq of infected potato tubers, tomato leaves, and several artificial media revealed that 56 and 207 transporters from P...
December 9, 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27936238/trehalose-6-phosphate-mediated-toxicity-determines-essentiality-of-otsb2-in-mycobacterium-tuberculosis-in-vitro-and-in-mice
#11
Jan Korte, Marina Alber, Carolina M Trujillo, Karl Syson, Hendrik Koliwer-Brandl, René Deenen, Karl Köhrer, Michael A DeJesus, Travis Hartman, William R Jacobs, Stephen Bornemann, Thomas R Ioerger, Sabine Ehrt, Rainer Kalscheuer
Trehalose biosynthesis is considered an attractive target for the development of antimicrobials against fungal, helminthic and bacterial pathogens including Mycobacterium tuberculosis. The most common biosynthetic route involves trehalose-6-phosphate (T6P) synthase OtsA and T6P phosphatase OtsB that generate trehalose from ADP/UDP-glucose and glucose-6-phosphate. In order to assess the drug target potential of T6P phosphatase, we generated a conditional mutant of M. tuberculosis allowing the regulated gene silencing of the T6P phosphatase gene otsB2...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27936192/insecticidal-activity-of-melaleuca-alternifolia-essential-oil-and-rna-seq-analysis-of-sitophilus-zeamais-transcriptome-in-response-to-oil-fumigation
#12
Min Liao, Jin-Jing Xiao, Li-Jun Zhou, Yang Liu, Xiang-Wei Wu, Ri-Mao Hua, Gui-Rong Wang, Hai-Qun Cao
BACKGROUND: The cereal weevil, Sitophilus zeamais is one of the most destructive pests of stored cereals worldwide. Frequent use of fumigants for managing stored-product insects has led to the development of resistance in insects. Essential oils from aromatic plants including the tea oil plant, Melaleuca alternifolia may provide environmentally friendly alternatives to currently used pest control agents. However, little is known about molecular events involved in stored-product insects in response to plant essential oil fumigation...
2016: PloS One
https://www.readbyqxmd.com/read/27936114/long-circulating-curcumin-loaded-liposome-formulations-with-high-incorporation-efficiency-stability-and-anticancer-activity-towards-pancreatic-adenocarcinoma-cell-lines-in-vitro
#13
Mohamed Mahmud, Adriana Piwoni, Nina Filiczak, Martyna Janicka, Jerzy Gubernator
The incorporation of hydrophobic drugs into liposomes improve their bioavailability and leads to increased stability and anticancer activity, along with decreased drug toxicity. Curcumin (Cur) is a natural polyphenol compound with a potent anticancer activity in pancreatic adenocarcinoma (PA). In the present study, different types of Cur-loaded liposomal formulations were prepared and characterized in terms of size, shape, zeta potential, optimal drug-to-lipid ratio and stability at 4°C, 37°C; and in human plasma in vitro...
2016: PloS One
https://www.readbyqxmd.com/read/27936089/interaction-potency-of-single-walled-carbon-nanotubes-with-dnas-a-novel-assay-for-assessment-of-hazard-risk
#14
Chunhe Yao, Cristina Carlisi, Yuning Li, Da Chen, Jianfu Ding, Yong-Lai Feng
Increasing use of single-walled carbon nanotubes (SWCNTs) necessitates a novel method for hazard risk assessment. In this work, we investigated the interaction of several types of commercial SWCNTs with single-stranded (ss) and double-stranded (ds) DNA oligonucleotides (20-mer and 20 bp). Based on the results achieved, we proposed a novel assay that employed the DNA interaction potency to assess the hazard risk of SWCNTs. It was found that SWCNTs in different sizes or different batches of the same product number of SWCNTs showed dramatically different potency of interaction with DNAs...
2016: PloS One
https://www.readbyqxmd.com/read/27936080/effects-of-pyrogallol-on-growth-and-cytotoxicity-of-wild-type-and-katg-mutant-strains-of-vibrio-vulnificus
#15
Ju Young Lim, Choon-Mee Kim, Joon Haeng Rhee, Young Ran Kim
Vibrio vulnificus is a causative agent of fatal septicemia and necrotic wound infection and the pathogen infection became an important public health problem in many counties. Vibrio vulnificus causes RtxA1 toxin-induced acute cell death. We tried to identify natural products that inhibit the acute cytotoxicity of V. vulnificus using a lactate hydrogenase assay. A polyphenol pyrogallol protected HeLa cells from V. vulnificus-induced cytotoxicity. Pyrogallol also decreased the growth of V. vulnificus; this inhibitory effect was more significant during log phase than stationary phase...
2016: PloS One
https://www.readbyqxmd.com/read/27936072/delonix-regia-leaf-extract-drle-a-potential-therapeutic-agent-for-cardioprotection
#16
Lung-Shuo Wang, Chun-Ting Lee, Wei-Lieh Su, Shih-Che Huang, Shu-Chi Wang
Delonix regia (Boj. Ex. Hook) is a flowering plant in the pea family found in tropical areas and its leaves are used informally to treat diseases in folk medicine. However, the cardioprotective effects in this plant are still unclear. In this study, we found that the Delonix regia leaf extract (DRLE) (400 mg/kg/d) can reduce the mortality rate in an isoproterenol (ISO)-induced heart injury and hypertrophy mouse model. Decreased serum levels of creatine phosphokinase, LDH, GOT, TNF-alpha and increased nitric oxide levels were found in DRLE-treated ISO-injured mice...
2016: PloS One
https://www.readbyqxmd.com/read/27936036/the-rs3957357c-t-snp-in-gsta1-is-associated-with-a-higher-risk-of-occurrence-of-hepatocellular-carcinoma-in-european-individuals
#17
Hanane Akhdar, Said El Shamieh, Orlando Musso, Romain Désert, Wissam Joumaa, Dominique Guyader, Caroline Aninat, Anne Corlu, Fabrice Morel
Glutathione S-transferases (GSTs) detoxify toxic molecules by conjugation with reduced glutathione and regulate cell signaling. Single nucleotide polymorphisms (SNPs) of GST genes have been suggested to affect GST functions and thus to increase the risk of human hepatocellular carcinoma (HCC). As GSTA1 is expressed in hepatocytes and the rs3957357C>T (TT) SNP is known to downregulate GSTA1 mRNA expression, the aims of this study were: (i) to explore the relationship between the TT SNP in GSTA1 and the occurrence of HCC; (ii) to measure GSTA1 mRNA expression in HCCs...
2016: PloS One
https://www.readbyqxmd.com/read/27935957/intracellular-zn-ii-intoxication-leads-to-dysregulation-of-the-perr-regulon-resulting-in-heme-toxicity-in-bacillus-subtilis
#18
Pete Chandrangsu, John D Helmann
Transition metal ions (Zn(II), Cu(II)/(I), Fe(III)/(II), Mn(II)) are essential for life and participate in a wide range of biological functions. Cellular Zn(II) levels must be high enough to ensure that it can perform its essential roles. Yet, since Zn(II) binds to ligands with high avidity, excess Zn(II) can lead to protein mismetallation. The major targets of mismetallation, and the underlying causes of Zn(II) intoxication, are not well understood. Here, we use a forward genetic selection to identify targets of Zn(II) toxicity...
December 9, 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27935952/neoadjuvant-gemcitabine-chemotherapy-followed-by-concurrent-imrt-simultaneous-boost-achieves-high-r0-resection-in-borderline-resectable-pancreatic-cancer-patients
#19
Xiaolun Huang, Jeanna L Knoble, Ming Zeng, Fernando N Aguila, Tara Patel, Lowell W Chambers, Honglin Hu, Hao Liu
BACKGROUND: To study the feasibility of down stage the borderline resectable pancreatic cancer (BRPC) to resectable disease, we reported our institutional results using an intensity-modulated radiation therapy (IMRT) simultaneous integrated boost (SIB) dose escalation approach to improve R0 resectability. METHODS: We reviewed our past 7 years of experience of using neoadjuvant induction chemotherapy with Gemcitabine followed by concurrent chemoradiaiton for BRPC...
2016: PloS One
https://www.readbyqxmd.com/read/27935865/bronchial-airway-gene-expression-signatures-in-mouse-lung-squamous-cell-carcinoma-and-their-modulation-by-cancer-chemopreventive-agents
#20
Donghai Xiong, Jing Pan, Qi Zhang, Eva Szabo, Mark Steven Miller, Ronald A Lubet, Ming You, Yian Wang
Due to exposure to environmental toxicants, a "field cancerization" effect occurs in the lung resulting in the development of a field of initiated but morphologically normal appearing cells in the damaged epithelium of bronchial airways with dysregulated gene expression patterns. Using a mouse model of lung squamous cell carcinoma (SCC), we performed transcriptome sequencing (RNA-Seq) to profile bronchial airway gene expression and found activation of the PI3K and Myc signaling networks in cytologically normal bronchial airway epithelial cells of mice with preneopastic lung SCC lesions, which was reversed by treatment with the PI3K Inhibitor XL-147 and pioglitazone, respectively...
December 7, 2016: Oncotarget
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