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https://www.readbyqxmd.com/read/28239980/rational-design-of-mini-size-carbon-nitride-nanosheets-with-double-excitation-and-ph-dependent-fluorescence-behaviors-for-two-photon-cell-imaging
#1
Liu Jinhua, DuoDuo Zhao, Lin Li, Minrui Weng, Chengwu Zhang, Shiyu Zhang, Jixin Zhu, Yong Feng, Kaimin Shih, Wei Huang
Synthesis of mini-size carbon nitride nanosheets (CNNSs) by using traditional ultrasonic method still remains a great challenge. Herein, Size-tunable and uniform mini-size CNNSs are synthesized by hydrothermal carbonization of the single polyethyleneimine (PEI) precursor.The as-obtained mini-size CNNSs possesses uniform size, good hydrophilicity, abundant nitrogen active sites, and not only exhibit double excitation- and pH-depending fluorescence behaviors, but two-photon exitation fluorescence. The resulting CNNSs display relatively low toxicity and can be efficiently delivered into live cells for two-photon fluorescence image, further confirm that the obtained CNNSs can potentially be used as fluorescence probes in biochemical applications...
February 26, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28239868/determination-of-two-potential-toxicity-metabolites-derived-from-the-disruption-of-pksct-gene-in-monascus-aurantiacus-li-as3-4384
#2
Zhibing Huang, Baowei Su, Yang Xu, Laisheng Li, Yanping Li
BACKGROUND: We previously demonstrated that disruption of the pksCT gene of Monascus led to over 98% decrease in its citrinin production capacity in Monascus (PHDS26).Two potentially toxic compounds, monascopyridine A (MPA) and monascopyridine B (MPB), were found in the fermentation products of the pksCT gene-disrupted Monascus. Moreover, a rapid and reliable HPLC method was developed for the simultaneous determination of MPA and MPB. We studied the effects of various extraction parameters and designed an orthogonal experiment to investigate the importance of each factor...
February 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28239782/inhibition-of-klebsiella-pneumoniae-growth-by-selected-australian-plants-natural-approaches-for-the-prevention-and-management-of-ankylosing-spondylitis
#3
V Winnett, J Sirdaarta, A White, F M Clarke, I E Cock
A wide variety of herbal remedies are used in traditional Australian medicine to treat inflammatory disorders, including autoimmune inflammatory diseases. One hundred and six extracts from 40 native Australian plant species traditionally used for the treatment of inflammation and/or to inhibit bacterial growth were investigated for their ability to inhibit the growth of a microbial trigger for ankylosing spondylitis (K. pneumoniae). Eighty-six of the extracts (81.1%) inhibited the growth of K. pneumoniae. The D...
February 27, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28239770/toxic-epidermal-necrolysis-in-a-child-with-lupus-associated-pancreatitis
#4
REVIEW
Stevic Marija, Budic Ivana, Ristic Nina, Nenadic Dragan, Bokun Zlatko, Jovanovic Branislav, Pejanovic Jelena, Simic Dusica
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatological conditions that are characterized by mucosal erosions, epidermal detachments and erosions. The most common causes of SJS and TEN are drugs; other causes such as systemic lupus erythematosus (SLE), vaccinations and infections have been rarely implicated. We present the case of a 14-year-old female patient with acute pancreatitis as an initial manifestation of systemic lupus erythematosus, complicated by the toxic epidermal necrolysis with a fatal outcome...
February 26, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28239731/formation-of-hybrid-abx3-perovskite-compounds-for-solar-cell-application-first-principles-calculations-of-effective-ionic-radii-and-determination-of-tolerance-factors
#5
Markus Becker, Thorsten Klüner, Michael Wark
The development of hybrid organic-inorganic perovskite solar cells is one of the most rapidly growing fields in the photovoltaic community and is on its way to challenge polycrystalline silicon and thin film technologies. High power conversion efficiencies can be achieved by simple processing with low cost. However, due to the limited long-term stability and environmental toxicity of lead in the prototypic CH3NH3PbI3, there is a need to find alternative ABX3 constitutional combinations in order to promote commercialization...
February 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28239691/wood-combustion-particles-induce-adverse-effects-to-normal-and-diseased-airway-epithelia
#6
Manuel Krapf, Lisa Künzi, Sandrine Allenbach, Emily A Bruns, Ilaria Gavarini, Imad El-Haddad, Jay G Slowik, André S H Prévôt, Luka Drinovec, Griša Močnik, Lutz Dümbgen, Matthias Salathe, Nathalie Baumlin, Constantinos Sioutas, Urs Baltensperger, Josef Dommen, Marianne Geiser
Residential wood burning is a major source of poorly characterized, deleterious particulate matter, whose composition and toxicity may vary with wood type, burning condition and photochemical age. The causative link between ambient wood particle constituents and observed adverse health effects is currently lacking. Here we investigate the relationship between chemical properties of primary and atmospherically aged wood combustion particles and acute toxicity in human airway epithelial cells. Emissions from a log wood burner were diluted and injected into a smog chamber for photochemical aging...
February 27, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28239674/dietary-supplementation-of-coenzyme-q10-plus-multivitamins-to-hamper-the-ros-mediated-cisplatin-ototoxicity-in-humans-a-pilot-study
#7
Felice Scasso, Andrea Elio Sprio, Luciano Canobbio, Chiara Scanarotti, Giorgio Manini, Giovanni Nicolao Berta, Anna Maria Bassi
Oxidative stress exerts major role in the pathogenesis of side effects of many antineoplastic drugs, including ototoxicity of cisplatin. In particular, increased levels of reactive oxygen species (ROS) represent one of the molecular mechanisms underlying the apoptosis of different types of hearing cells. Antioxidants and ROS scavengers may thus represent potential therapeutic options to prevent platinum-associated ototoxicity. The aim of this preliminary case-control study was to explore the efficacy of a dietary antioxidant supplement, in order to hamper the occurrences of ototoxicity in patients undergoing cisplatin chemotherapy...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28239562/modeling-of-variability-and-uncertainty-in-human-health-risk-assessment
#8
Palash Dutta
Health risk assessments have been carried out worldwide to examine potential health risk due to exposure to toxic contaminants in various environments. In risk assessment, it is most important to know the nature of all available information, data or model parameters. It is observed that available information/data are tainted with uncertainty and variability in the same time, i.e., uncertainty and variability co-exist. In such situation it is important to devise method for processing both uncertainty and variability into same framework and which is an open issue...
2017: MethodsX
https://www.readbyqxmd.com/read/28239534/transcriptome-and-metabolome-analysis-of-liver-and-kidneys-of-rats-chronically-fed-nk603-roundup-tolerant-genetically-modified-maize
#9
Robin Mesnage, Matthew Arno, Gilles-Eric Séralini, Michael N Antoniou
BACKGROUND: A previous 2-year rat feeding trial assessing potential toxicity of NK603 Roundup-tolerant genetically modified maize revealed blood and urine biochemical changes indicative of liver and kidney pathology. In an effort to obtain deeper insight into these findings, molecular profiling of the liver and kidneys from the same animals was undertaken. RESULTS: Transcriptomics showed no segregation of NK603 maize and control feed groups with false discovery rates ranging from 43 to 83% at a cut-off p value of 1%...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28239469/combination-immunotherapy-a-road-map
#10
REVIEW
Patrick A Ott, F Stephen Hodi, Howard L Kaufman, Jon M Wigginton, Jedd D Wolchok
Cancer immunotherapy and in particular monoclonal antibodies blocking the inhibitory programed cell death 1 pathway (PD-1/PD-L1) have made a significant impact on the treatment of cancer patients in recent years. However, despite the remarkable clinical efficacy of these agents in a number of malignancies, it has become clear that they are not sufficiently active for many patients. Initial evidence, for example with combined inhibition of PD-1 and CTLA-4 in melanoma and non-small cell lung cancer (NSCLC), has highlighted the potential to further enhance the clinical benefits of monotherapies by combining agents with synergistic mechanisms of action...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28239468/immunotherapy-associated-autoimmune-hemolytic-anemia
#11
Uqba Khan, Farman Ali, Muhammad Siddique Khurram, Awais Zaka, Tarik Hadid
BACKGROUND: Immunotherapy has been widely used in the treatment of several solid and hematologic malignancies. Checkpoint inhibitors have been the forefront of cancer immunotherapy in recent years. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) pathway are the prototypic checkpoint targets for immunotherapy. When combined, CTLA-4 and PD-1 checkpoint inhibitors work synergistically, but with increased probability of toxicity. The following case represents an unusual adverse effect of combined treatment with ipilimumab and nivolumab used for treatment of metastatic melanoma...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28239463/enhancing-adoptive-cancer-immunotherapy-with-v%C3%AE-2v%C3%AE-2-t-cells-through-pulse-zoledronate-stimulation
#12
Mohanad H Nada, Hong Wang, Grefachew Workalemahu, Yoshimasa Tanaka, Craig T Morita
BACKGROUND: Human γδ T cells expressing Vγ2Vδ2 T cell receptors monitor foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis to mediate immunity to microbes and tumors. Adoptive immunotherapy with Vγ2Vδ2 T cells has been used to treat cancer patients with partial and complete remissions. Most clinical trials and preclinical studies have used continuous zoledronate exposure to expand Vγ2Vδ2 cells where zoledronate is slowly diluted over the course of the culture...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28239385/hydrogen-peroxide-pretreatment-mitigates-cadmium-induced-oxidative-stress-in-brassica-napus-l-an-intrinsic-study-on-antioxidant-defense-and-glyoxalase-systems
#13
Mirza Hasanuzzaman, Kamrun Nahar, Sarvajeet S Gill, Hesham F Alharby, Bam H N Razafindrabe, Masayuki Fujita
Cadmium (Cd) is considered as one of the most toxic metals for plant growth and development. In the present study, we investigated the role of externally applied hydrogen peroxide (H2O2) in regulating the antioxidant defense and glyoxalase systems in conferring Cd-induced oxidative stress tolerance in rapeseed (Brassica napus L.). Seedlings were pretreated with 50 μM H2O2 for 24 h. These pretreated seedlings as well as non-pretreated seedlings were grown for another 48 h at two concentrations of CdCl(2) (0...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28239170/diabetic-nephropathy-lipid-toxicity-drives-renal-disease
#14
Liesbet Lieben
No abstract text is available yet for this article.
February 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28239160/insights-into-the-molecular-mechanisms-of-polygonum-multiflorum-thunb-induced-liver-injury-a-computational-systems-toxicology-approach
#15
Yin-Yin Wang, Jie Li, Zeng-Rui Wu, Bo Zhang, Hong-Bin Yang, Qin Wang, Ying-Chun Cai, Gui-Xia Liu, Wei-Hua Li, Yun Tang
An increasing number of cases of herb-induced liver injury (HILI) have been reported, presenting new clinical challenges. In this study, taking Polygonum multiflorum Thunb (PmT) as an example, we proposed a computational systems toxicology approach to explore the molecular mechanisms of HILI. First, the chemical components of PmT were extracted from 3 main TCM databases as well as the literature related to natural products. Then, the known targets were collected through data integration, and the potential compound-target interactions (CTIs) were predicted using our substructure-drug-target network-based inference (SDTNBI) method...
February 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28239059/contact-and-repellant-activities-of-zerumbone-and-its-analogues-from-the-essential-oil-of-zingiber-zerumbet-l-smith-against-lasioderma-serricorne
#16
Yan Wu, Shan-Shan Guo, Dong-Ye Huang, Cheng-Fang Wang, Jian-Yu Wei, Zhi-Hua Li, Jian-Sheng Sun, Jia-Feng Bai, Zhao-Fu Tian, Ping-Juan Wang, Shu-Shan Du
The contact toxicity and repellent activities of the essential oil extracted from the rhizomes of Zingiber zerumbet (L.) Smith (Zingiberaceae) was evaluated against cigarette beetles (Lasioderma serricorne). The essential oil obtained by hydrodistillation was investigated by GC-FID and GC-MS. The main constituents of the essential oil were zerumbone (40.2%), α-caryophyllene (8.6%), humulene epoxide II (7.3%), camphene (5.9%) and fenchene (4.7%). Zerumbone and its analogues totally are accounting for 60.3% of the essential oil...
February 24, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28238961/alectinib-for-patients-with-alk-rearrangement-positive-non-small-cell-lung-cancer-and-a-poor-performance-status-lung-oncology-group-in-kyushu-1401
#17
Eiji Iwama, Yasushi Goto, Haruyasu Murakami, Taishi Harada, Shinsuke Tsumura, Hiroyuki Sakashita, Yoshiaki Mori, Noriaki Nakagaki, Yuka Fujita, Masahiro Seike, Akihiro Bessho, Manabu Ono, Akihito Okazaki, Hiroaki Akamatsu, Ryotaro Morinaga, Shinichiro Ushijima, Takayuki Shimose, Shoji Tokunaga, Akinobu Hamada, Nobuyuki Yamamoto, Yoichi Nakanishi, Kenji Sugio, Isamu Okamoto
INTRODUCTION: Alectinib has shown marked efficacy and safety in patients with ALK rearrangement-positive non-small cell lung cancer (NSCLC) and a good performance status (PS). It has remained unclear whether alectinib might also be beneficial for such patients with a poor PS. METHODS: Eligible patients with advanced ALK rearrangement-positive NSCLC and a PS of 2 to 4 received alectinib orally at 300 mg twice daily. The primary end point of the study was objective response rate (ORR), and the most informative secondary end point was rate of PS improvement...
February 23, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28238932/mono-2-ethylhexyl-phthalate-induced-sertoli-cell-injury-stimulates-the-production-of-pro-inflammatory-cytokines-in-fisher-344-rats
#18
Angela R Stermer, Caitlin J Murphy, Rashin Ghaffari, Kristin R Di Bona, Jorine J Voss, John H Richburg
Exposure of rodents to the Sertoli cell (SC) toxicant mono-(2-ethylhexyl) phthalate (MEHP) has been reported to trigger an infiltration of macrophages into the testis in an age- and species-dependent manner. Here we challenge the hypothesis that the peripubertal rat-specific infiltration of macrophages after MEHP exposure is due, in part, to an increase in SC-specific inflammatory cytokine expression. To rule out that GC apoptosis itself is responsible for macrophage recruitment, rats were exposed to a direct germ cell toxicant, methoxy acetic acid (MAA), but no infiltration of macrophages was observed...
February 23, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28238904/proteomic-toxicological-and-immunogenic-characterization-of-mexican-west-coast-rattlesnake-crotalus-basiliscus-venom-and-its-immunological-relatedness-with-the-venom-of-central-american-rattlesnake-crotalus-simus
#19
Álvaro Segura, María Herrera, Francisco Reta Mares, Claudia Jaime, Andrés Sánchez, Mariángela Vargas, Mauren Villalta, Aarón Gómez, José María Gutiérrez, Guillermo León
: The venom of the Mexican west-coast rattlesnake (Crotalus basiliscus) was characterized for its protein composition, toxicological profile and immunogenic properties. This venom is composed of 68% Zn(2+)-dependent metalloproteinases (SVMPs), 14% phospholipases A2 (PLA2s), 11% serine proteinases, 4% SVMPs-inhibitor tripeptides (SVMP-ITs), 2% bradykinin-potentiating peptides (BPPs), 0.6% cysteine-rich secretory proteins (CRISPs), and 0.2% l-amino acid oxidases (LAAOs). SVMPs present in the venom are responsible for azocasein hydrolysis and hemorrhagic activity, but their contribution to the lethal activity of the venom in mice is masked by the neurotoxic activity of PLA2s, which in addition are also responsible for myotoxic activity...
February 23, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28238900/safety-and-biosimilarity-of-ior-%C3%A2-leukocim-compared-to-neupogen-%C3%A2-based-on-toxicity-pharmacodynamic-and-pharmacokinetic-studies-in-the-sprague-dawley-rat
#20
Albert Licollari, Katherine Riddle, Simon R Taylor, Nuris Ledon, Gordon T Bolger
This study examined the safety, pharmacodynamic and pharmacokinetic similarity of the human recombinant filgrastim products ior(®)LeukoCIM and Neupogen(®) following a 28-day repeated subcutaneous dose administration in male and female Sprague-Dawley rats with a 14-day recovery period. Safety profiling was based on clinical observations, clinical pathology and pathology findings for control rats dosed with vehicle and rats dosed either with 15, 75 and 150 μg/kg of ior(®)LeukoCIM or 150 μg/kg of Neupogen(®)...
February 23, 2017: Journal of Pharmaceutical Sciences
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