keyword
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#1
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537038/novel-optical-coherence-tomography-findings-in-a-patient-with-methanol-toxicity-a-case-report
#2
Burcu Işık, Mehmet Giray Ersoz, Mehmet Dokur, Ismail Yıldız, Mehmet Sami Islamoğlu
We report a case of acute methanol toxicity with unique optical coherence tomography findings. A 56-year-old man was referred to our ophthalmology clinic with a history of handmade vodka consumption and vision loss. On ophthalmologic examination, his vision was 20/100 in his right eye and 20/200 in his left eye. Bilateral mild optic disk hyperemia was detected on fundus examination. Because of the severity of systemic symptoms in such cases, it is very difficult to include optical coherence tomography in the ophthalmologic examination...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38536968/manganese-nanoparticles-synthesis-mechanisms-of-influence-on-plant-resistance-to-stress-and-prospects-for-application-in-agricultural-chemistry
#3
REVIEW
Alla I Perfileva, Konstantin V Krutovsky
Manganese (Mn) is an important microelement for the mineral nutrition of plants, but it is not effectively absorbed from the soil and mineral salts added thereto and can also be toxic in high concentrations. Mn nanoparticles (NPs) are less toxic, more effective, and economical than Mn salts due to their nanosize. This article critically reviews the current publications on Mn NPs, focusing on their effects on plant health, growth, and stress tolerance, and explaining possible mechanisms of their effects. This review also provides basic information and examples of chemical, physical, and ecological ("green") methods for the synthesis of Mn NPs...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38536874/gray-whale-eschrichtius-robustus-post-mortem-findings-from-december-2018-through-2021-during-the-unusual-mortality-event-in-the-eastern-north-pacific
#4
JOURNAL ARTICLE
Stephen Raverty, Pádraig Duignan, Denise Greig, Jessica L Huggins, Kathy Burek Huntington, Michael Garner, John Calambokidis, Paul Cottrell, Kerri Danil, Dalin D'Alessandro, Deborah Duffield, Moe Flannery, Frances Md Gulland, Barbie Halaska, Dyanna M Lambourn, Taylor Lehnhart, Jorge Urbán R, Teri Rowles, James Rice, Kate Savage, Kristin Wilkinson, Justin Greenman, Justin Viezbicke, Brendan Cottrell, P Dawn Goley, Maggie Martinez, Deborah Fauquier
Beginning in December 2018, increased numbers of gray whale (Eschrichtius robustus) strandings were reported along the west coast of Mexico, the United States, and Canada, prompting declaration of a gray whale Unusual Mortality Event (UME) by the United States National Marine Fisheries Service. Although strandings declined in 2020 and 2021 from a peak in 2019, the UME is still ongoing as of fall 2023. Between 17 December 2018 and 31 December 2021, 503 animals stranded along the west coast of North America, with 226 strandings in Mexico, 71 in California, 12 in Oregon, 56 in Washington, 21 in British Columbia, and 117 in Alaska...
2024: PloS One
https://read.qxmd.com/read/38536835/initial-agronomic-benefits-of-enhanced-weathering-using-basalt-a-study-of-spring-oat-in-a-temperate-climate
#5
JOURNAL ARTICLE
Kirstine Skov, Jez Wardman, Matthew Healey, Amy McBride, Tzara Bierowiec, Julia Cooper, Ifeoma Edeh, Dave George, Mike E Kelland, Jim Mann, David Manning, Melissa J Murphy, Ryan Pape, Yit A Teh, Will Turner, Peter Wade, Xinran Liu
Addressing soil nutrient degradation and global warming requires novel solutions. Enhanced weathering using crushed basalt rock is a promising dual-action strategy that can enhance soil health and sequester carbon dioxide. This study examines the short-term effects of basalt amendment on spring oat (Avena sativa L.) during the 2022 growing season in NE England. The experimental design consisted of four blocks with control and basalt-amended plots, and two cultivation types within each treatment, laid out in a split plot design...
2024: PloS One
https://read.qxmd.com/read/38536739/a-scoping-review-of-the-mechanisms-underlying-developmental-anesthetic-neurotoxicity
#6
JOURNAL ARTICLE
Matthew Thomas Borzage, Bradley S Peterson
Although anesthesia makes painful or uncomfortable diagnostic and interventional health care procedures tolerable, it may also disrupt key cellular processes in neurons and glia, harm the developing brain, and thereby impair cognition and behavior in children. Many years of studies using in vitro, animal behavioral, retrospective database studies in humans, and several prospective clinical trials in humans have been invaluable in discerning the potential toxicity of anesthetics. The objective of this scoping review was to synthetize the evidence from preclinical studies for various mechanisms of toxicity across diverse experimental designs and relate their findings to those of recent clinical trials in real-world settings...
March 27, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38536670/tyrosinase-modified-uhmw-selp-polymers-as-wet-and-underwater-adhesives-to-achieve-multi-interface-adhesion
#7
JOURNAL ARTICLE
Wenxin Huang, Sijia Wang, Zhaoxuan Feng, Dasen Zhou, Wenqin Bai
The presence of a hydration layer in humid and underwater environments challenges adhesive-substrate interactions and prevents effective bonding, which has become a significant obstacle to the development of adhesives in the industrial and biomedical fields. In this study, ultrahigh-molecular-weight (UHMW) silk-elastin-like proteins (SELP) with 3,4-dihydroxyphenylalanine (DOPA) converted from tyrosine residues by tyrosinase exhibited excellent adhesive properties on different interfaces, such as glass, aluminum, wood, polypropylene sheets, and pigskin, under both dry and wet conditions...
March 27, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38536665/proteomic-examination-of-polyester-polyurethane-degradation-by-streptomyces-sp-pu10-diverting-polyurethane-intermediates-to-secondary-metabolite-production
#8
JOURNAL ARTICLE
Brana Pantelic, Romanos Siaperas, Clémence Budin, Tjalf de Boer, Evangelos Topakas, Jasmina Nikodinovic-Runic
Global plastic waste accumulation has become omnipresent in public discourse and the focus of scientific research. Ranking as the sixth most produced polymer globally, polyurethanes (PU) significantly contribute to plastic waste and environmental pollution due to the toxicity of their building blocks, such as diisocyanates. In this study, the effects of PU on soil microbial communities over 18 months were monitored revealing that it had marginal effects on microbial diversity. However, Streptomyces sp...
March 2024: Microbial Biotechnology
https://read.qxmd.com/read/38536660/comparative-assessment-of-drug-lag-for-approved-oncology-targeted-therapies-between-saudi-arabia-the-united-states-and-the-european-union
#9
JOURNAL ARTICLE
Mohammed Alnuhait, Abdullah Alshammari, Manar Alharbi, Lina AlOtaibi, Reem Alharbi, Attiah Khobrani, Nora Alkhudair, Majed Alshamrani, Abdullah M Alrajhi
INTRODUCTION: Pharmaceutical regulation on a global scale is a complex process, with regulatory bodies overseeing various aspects, including licensing, registration, manufacturing, marketing, and labeling. Among these, the USFDA plays a crucial role in upholding public health. The pharmaceutical industry contributes significantly to well-being by developing and distributing therapeutic agents. The journey of evaluating new pharmaceuticals involves meticulous examination through several phases, from safety and efficacy assessments to toxicity evaluation...
March 27, 2024: Therapeutic Innovation & Regulatory Science
https://read.qxmd.com/read/38536627/fatal-intoxications-with-zopiclone-a-cause-for-concern
#10
JOURNAL ARTICLE
Lova Tralla, Sara Gustavsson, Carl Söderberg, Anna K Jönsson, Fredrik C Kugelberg
INTRODUCTION: Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. METHODS: All forensic autopsy cases positive for zopiclone in femoral blood during 2012-2020 were selected. Among these cases, fatalities caused by intoxication according to the cause of death certificates issued by the forensic pathologist were identified...
March 27, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38536611/heterologous-expression-of-human-ifn%C3%AE-and-anti-il17-antibody-in-leishmania-tarentolae-promastigote
#11
JOURNAL ARTICLE
Arian Karimi Rouzbahani, Seyedeh-Zeinab Hosseini, Mojgan Bandehpour, Bahram Kazemi, Afsaneh Tavasoli, Amirreza Javadi Mamaghani, Farnaz Kheirandish
BACKGROUND: Leishmania is an intracellular flagellate protozoan parasite that causes a wide range of clinical diseases in humans. The basis of immunological resistance against leishmaniasis depends on Thl reactions and is within the time period of cytokine function. METHODS: In this study, human anti-IL17 antibody and IFNγ-producing promastigote were produced to be used in leishmanization. A sequence of light and heavy chains' gene of anti-IL17 antibody and human IFNγ (hIFNγ) was obtained from the NCBI database and synthesized in the ECORV reaction site in the plasmid pGH, which it's called pGH-hIFNγ-antiIL17...
March 27, 2024: Acta Parasitologica
https://read.qxmd.com/read/38536586/prevalence-of-and-factors-associated-with-financial-toxicity-after-pancreatectomy-and-gastrectomy
#12
JOURNAL ARTICLE
Yuki Hirata, Connie To, Heather Lyu, Grace L Smith, Joyce P Samuel, Hop S Tran Cao, Brian D Badgwell, Matthew H G Katz, Naruhiko Ikoma
BACKGROUND: Financial toxicity (FT) refers to the adverse impact of cancer treatment costs on patients' experiences, potentially leading to poor adherence to treatment and outcomes. However, the prevalence of FT among patients undergoing major upper gastrointestinal cancer operations, as well as factors associated with FT, remain unclear. METHODS: We conducted a cross-sectional study by sending the Comprehensive Score for financial Toxicity (COST) survey and Surgery-Q (a survey specifically developed for this study) to patients who underwent gastrectomy or pancreatectomy for malignant disease at our institution in 2019-2021...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38536576/bruton-tyrosine-kinase-inhibition-an-effective-strategy-to-manage-waldenstr%C3%A3-m-macroglobulinemia
#13
REVIEW
Reema K Tawfiq, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The treatment of Waldenström macroglobulinemia (WM) has evolved over the past decade. With the seminal discoveries of MYD88 and CXCR warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) mutations in WM cells, our understanding of the disease biology and treatment has improved. The development of a new class of agents, Bruton tyrosine kinase inhibitors (BTKi), has substantially impacted the treatment paradigm of WM. Herein, we review the current and emerging BTKi and the evidence for their use in WM...
March 27, 2024: Current Hematologic Malignancy Reports
https://read.qxmd.com/read/38536558/a-deep-learning-model-for-translating-ct-to-ventilation-imaging-analysis-of-accuracy-and-impact-on-functional-avoidance-radiotherapy-planning
#14
JOURNAL ARTICLE
Zhen Hou, Youyong Kong, Junxian Wu, Jiabing Gu, Juan Liu, Shanbao Gao, Yicai Yin, Ling Zhang, Yongchao Han, Jian Zhu, Shuangshuang Li
PURPOSE: Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study introduces a novel deep-learning model directly translating planning CT images into CTVI. We investigated the accuracy of generated images and the impact on functional avoidance planning. MATERIALS AND METHODS: Paired planning CT and 4DCT scans from 48 patients with NSCLC were randomized to training (n = 41) and testing (n = 7) data sets...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38536500/the-interactions-of-subcellular-organelles-in-pulmonary-fibrosis-induced-by-carbon-black-nanoparticles-a-comprehensive-review
#15
REVIEW
Lei Bao, Qingping Liu, Jingyuan Wang, Lili Shi, Yaxian Pang, Yujie Niu, Rong Zhang
Owing to the widespread use and improper emissions of carbon black nanoparticles (CBNPs), the adverse effects of CBNPs on human health have attracted much attention. In toxicological research, carbon black is frequently utilized as a negative control because of its low toxicity and poor solubility. However, recent studies have indicated that inhalation exposure to CBNPs could be a risk factor for severe and prolonged pulmonary inflammation and fibrosis. At present, the pathogenesis of pulmonary fibrosis induced by CBNPs is still not fully elucidated, but it is known that with small particle size and large surface area, CBNPs are more easily ingested by cells, leading to organelle damage and abnormal interactions between organelles...
March 27, 2024: Archives of Toxicology
https://read.qxmd.com/read/38536476/herombopag-for-the-treatment-of-persistent-thrombocytopenia-following-hematopoietic-stem-cell-transplantation
#16
JOURNAL ARTICLE
Miao Zhou, Tongyu Li, Ping Zhang, Yanli Lai, Lixia Sheng, Guifang Ouyang
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) stands as a pivotal treatment for hematologic malignancies, often considered the sole effective treatment option. A frequent complication following allo-HSCT is poor graft function (PGF), with one of its primary manifestations being persistent thrombocytopenia (PT), comprising prolonged isolated thrombocytopenia (PIT) and secondary failure of platelet recovery (SFPR). Conventional treatment methods have had poor efficacy and a high transplantation-associated mortality rate...
March 27, 2024: Annals of Hematology
https://read.qxmd.com/read/38536457/sbys1-and-sbwrky72-regulate-cd-tolerance-and-accumulation-in-sweet-sorghum
#17
JOURNAL ARTICLE
Weitao Jia, Zijing Guo, Sulian Lv, Kangqi Lin, Yinxin Li
SbYS1 and its upstream transcription factor SbWRKY72 were involved in Cd tolerance and accumulation and are valuable for developing sweet sorghum germplasm with high-Cd tolerance or accumulation ability through genetic manipulation. Cadmium (Cd) is highly toxic and can severely affect human health. Sweet sorghum, as an energy crop, shows great potential in extracting cadmium from Cd-contaminated soils. However, its molecular mechanisms of Cd-tolerance and -accumulation remain largely unknown. Here, we isolated a YSL family gene SbYS1 from the sweet sorghum genotype with high Cd accumulation ability and the expression of SbYS1 in roots was induced by cadmium...
March 27, 2024: Planta
https://read.qxmd.com/read/38536431/enhancing-safety-in-tumescent-liposuction-managing-sedation-related-respiratory-issues-and-serious-complications-under-deep-sedation-with-the-propofol-ketamine-protocol
#18
JOURNAL ARTICLE
Eun Ju Kim, Hyunju Kim, Younchan Park
BACKGROUND: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative. METHODS: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38536125/overcoming-solubility-challenges-liposomal-isocoq-carbazole-as-a-promising-anti-tumor-agent-for-inoperable-and-radiation-insensitive-cancers
#19
JOURNAL ARTICLE
Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
This study evaluated the potential of isoCoQ-Carbazole, a diheterocyclic analog of isoCA-4, as an anti-tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ-Carbazole loaded liposomes significantly reduced tumor growth in a CA-4-resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38536007/acute-myocarditis-an-overview-of-pathogenesis-diagnosis-and-management
#20
JOURNAL ARTICLE
Marina Zafeiri, Kristopher Knott, Temi Lampejo
Acute myocarditis encompasses a diverse presentation of inflammatory cardiomyopathies with infectious and non-infectious triggers. The clinical presentation is heterogeneous, from subtle symptoms like mild chest pain to life-threatening fulminant heart failure requiring urgent advanced hemodynamic support. This review provides a comprehensive overview of the current state of knowledge regarding the pathogenesis, diagnostic approach, management strategies, and directions for future research in acute myocarditis...
March 27, 2024: Panminerva Medica
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