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https://www.readbyqxmd.com/read/29679905/qing-brick-tea-qbt-aqueous-extract-protects-monosodium-glutamate-induced-obese-mice-against-metabolic-syndrome-and-involves-up-regulation-transcription-factor-nuclear-factor-erythroid-2-related-factor-2-nrf2-antioxidant-pathway
#1
Wenqi Gao, Changyi Xiao, Jun Hu, Biaoxin Chen, Chunyan Wang, Bangping Cui, Pengyi Deng, Jian Yang, Zhifang Deng
BACKGROUND: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms. METHOD: Monosodium glutamate-induced obese mice were used to evaluate the anti-Mets effects of QBT. Content levels of malonaldehyde (MDA), reactive oxygen species (ROS) and protein carbonylation, antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR) in the skeletal muscle were assessed by commercial kits, respectively...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679027/author-correction-circulating-haptoglobin-and-metabolic-syndrome-in-renal-transplant-recipients
#2
Isidor Minović, Michele F Eisenga, Ineke J Riphagen, Else van den Berg, Jenny Kootstra-Ros, Anne-Roos S Frenay, Harry van Goor, Gerald Rimbach, Tuba Esatbeyoglu, Andy P Levy, Carlo A J M Gaillard, Johanna M Geleijnse, Manfred L Eggersdorfer, Gerjan J Navis, Ido P Kema, Stephan J L Bakker
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679023/interventions-for-lower-extremity-peripheral-artery-disease
#3
REVIEW
Jade S Hiramoto, Martin Teraa, Gert J de Borst, Michael S Conte
Peripheral artery disease (PAD) of the lower extremities is a common manifestation of atherosclerosis that is increasing in global prevalence and in the associated public health costs. Ageing of the general population, combined with the pandemics of diabetes mellitus, metabolic syndrome, and tobacco use, is a major underlying factor. A broad range of care providers are involved in the management of patients with PAD, and all health-care professionals require familiarity with the risk factors, diagnosis, and treatment options for this common disease...
April 20, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29678877/deferoxamine-ameliorates-adipocyte-dysfunction-by-modulating-iron-metabolism-in-ob-ob-mice
#4
Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan, Chuang Guo
OBJECTIVE: The mechanisms underlying obesity and anti-obesity processes have garnered remarkable attention as potential therapeutic targets for obesity-associated metabolic syndromes. Our prior work has shown the healing efficacy of iron reduction therapies for hepatic steatosis in a rodent model of diabetes and obesity. In this study, we investigated how iron depletion by deferoxamine (DFO) affected adipocyte dysfunction in the epididymal adipose tissues of ob/ob mice. METHODS: Male ob/ob mice were assigned to either a vehicle-treated or DFO-treated group...
April 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#5
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678491/polycystic-ovary-syndrome-pcos-an-inflammatory-systemic-lifestyle-endocrinopathy
#6
REVIEW
Seema Patel
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females...
April 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29678316/correlation-of-plasma-b-type-natriuretic-peptide-levels-with-metabolic-risk-markers
#7
José Armando Ahued-Ortega, Plácido Enrique León-García, Elizabeth Hernández-Pérez
BACKGROUND AND OBJECTIVE: Natriuretic peptide type B (BNP) is a marker of myocardium injury. This peptide has been associated with metabolic risk markers, although controversy exists in this regard. The aim of the present study was to determine the correlation of plasma BNP levels with metabolic risk parameters. MATERIALS AND METHODS: A retrospective, observational study that included 152 patients, who were classified according to their clinical diagnosis as patients with metabolic syndrome...
April 17, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29678227/humoral-and-cell-mediated-immune-responses-to-influenza-vaccination-in-equine-metabolic-syndrome-ems-horses
#8
Sarah Elzinga, Stephanie Reedy, Virginia D Barker, Thomas M Chambers, Amanda A Adams
Obesity is an increasing problem in the equine population with recent reports indicating that the percentage of overweight horses may range anywhere from 20.6-51%. Obesity in horses has been linked to more serious health concerns such as equine metabolic syndrome (EMS). EMS is a serious problem in the equine industry given its defining characteristics of insulin dysregualtion and obesity, as well as the involvement of laminitis. Little research however has been conducted to determine the effects of EMS on routine healthcare of these horses, in particular how they respond to vaccination...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29678174/age-and-gender-specific-distribution-of-metabolic-syndrome-components-in-east-china-role-of-hypertriglyceridemia-in-the-spect-china-study
#9
Boren Jiang, Yanjun Zheng, Yingchao Chen, Yi Chen, Qin Li, Chunfang Zhu, Ningjian Wang, Bing Han, Hualing Zhai, Dongping Lin, Yingli Lu
BACKGROUND: Chinese population are experiencing remarkably changes of economic and cultural environments. The present study was to examine the prevalence of metabolic syndrome (MetS) by age between genders and to investigate the current characteristics of MetS and its components in China. METHODS: SPECT-China is a population-based cross-sectional survey on Chinese adults aged ≥18 years in East China. A total of 10,441 Chinese residents participated in anthropometric and laboratory measurements...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29678132/neck-circumference-may-be-a-valuable-tool-for-screening-individuals-with-obesity-findings-from-a-young-chinese-population-and-a-meta-analysis
#10
Xiaoting Pei, Li Liu, Mustapha Umar Imam, Ming Lu, Yanzi Chen, Panpan Sun, Yaxin Guo, Yiping Xu, Zhiguang Ping, Xiaoli Fu
BACKGROUND: Central obesity and overweight/obesity can result in various chronic non-communicable diseases, such as cardiovascular disease, metabolic syndrome, and diabetes mellitus. Waist circumference (WC) and body mass index (BMI) are widely used to measure obesity despite their limitations. For example, WC and BMI cannot be measured in pregnant women and subjects with abdominal ascites or masses. Therefore, this study aims to determine the efficacy of neck circumference (NC) as a tool for screening central obesity and overweight/obesity...
April 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29677618/altered-serum-levels-of-vascular-endothelial-growth-factor-in-first-episode-drug-na%C3%A3-ve-and-chronic-medicated-schizophrenia
#11
Fei Ye, Qiongqiong Zhan, Wenhuan Xiao, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
There is much evidence of a relationship between alterations in the brain's regional cellular energy metabolism and blood flow in schizophrenic. Vascular endothelial growth factor (VEGF) plays a role in the pathogenesis of neuropsychiatric illnesses. So, we compared serum VEGF levels in drug-naïve first-episode psychotic (FEP) and chronically medicated schizophrenic to examine if a correlation existed between VEGF and psychopathological symptoms. The serum VEGF levels were assessed in 46 FEP patients, 47 chronic medicated patients and 50 healthy controls...
April 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29676541/primary-cilia-as-a-signaling-platform-for-control-of-energy-metabolism
#12
REVIEW
Do Kyeong Song, Jong Han Choi, Min Seon Kim
Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, such as Bardet-Biedl syndrome and Alström syndrome, which manifest as obesity...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29676471/vitamin-d3-regulates-steroidogenesis-in-granulosa-cells-through-amp-activated-protein-kinase-ampk-activation-in-a-mouse-model-of-polycystic-ovary-syndrome
#13
Shabnam Bakhshalizadeh, Fardin Amidi, Reza Shirazi, Maryam Shabani Nashtaei
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in reproductive-aged women. Hormonal abnormality caused by steroidogenesis disturbances appears to be the main culprit of the clinical picture in PCOS. Vitamin D3 could regulate steroidogenesis in granulosa cells, but the mechanism of action of vitamin D3 on steroidogenesis remains unknown. AMP-activated protein kinase (AMPK) has a modulating role in steroid hormone production. We investigated the effect of vitamin D3 on steroidogenesis in cultured granulosa cells of dehydroepiandrosterone-induced PCOS mice and studied the involvement of AMPK signalling pathway in the current process...
April 20, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29675927/tributyltin-reduces-the-levels-of-serum-adiponectin-and-activity-of-akt-and-induces-metabolic-syndrome-in-male-mice
#14
Haotian Yan, Hao Guo, Dong Cheng, Ruirui Kou, Cuili Zhang, Jiliang Si
Tributyltin (TBT), a proven environmental obesogen, functions as a nanomolar agonist of the peroxisome proliferator activated receptor-γ (PPARγ). However, the adverse effects of TBT on metabolism are incompletely understood. In this study, male ICR mice were administered TBT (5 and 50 μg·kg- 1 ) by an intraperitoneal injection once every 3 days for 30 days from 28 days of age and bred for another 30 days after the last administration of TBT. We analyzed the effects of these exposures on the fat depot weights, serum lipid profile, serum leptin and adiponectin, hepatic lipid accumulation, and activity of AKT in the liver and skeletal muscle isolated from mice 8 mins after receiving an insulin injection...
April 20, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29675621/myocardial-function-in-primary-antiphospholipid-syndrome-using-speckle-tracking-echocardiography
#15
Gabriela Medina, Eduardo Gómez-Bañuelos, Erick Calderón-Aranda, María Pilar Cruz-Domínguez, Olga Vera-Lastra, Luis J Jara
Antiphospholipid syndrome (APS) patients have high cardiovascular risk. Speckle-tracking echocardiography (STE) detects myocardial function. To evaluate the myocardial function in primary APS (PAPS) patients using two-dimensional echocardiography (2-D) obtaining values of left ventricle global longitudinal strain (GLS) by STE. Patients with PAPS, > 16 years, both genders, without signs and symptoms of heart disease were recruited and matched with healthy controls by age and gender. Demographic, clinical data, and cardiovascular risk factors were recorded...
April 19, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29675134/leptin-and-leptin-resistance-in-the-pathogenesis-of-obstructive-sleep-apnea-a-possible-link-to-oxidative-stress-and-cardiovascular-complications
#16
REVIEW
Slava Berger, Vsevolod Y Polotsky
Obesity-related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic increases in circulating levels of leptin, a hormone produced in adipose tissue. Leptin acts in the hypothalamus to suppress food intake and increase metabolic rate. However, obese individuals are resistant to metabolic effects of leptin. Leptin also activates the sympathetic nervous system without any evidence of resistance, possibly because these effects occur peripherally without a need to penetrate the blood-brain barrier...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29675131/glycine-increases-insulin-sensitivity-and-glutathione-biosynthesis-and-protects-against-oxidative-stress-in-a-model-of-sucrose-induced-insulin-resistance
#17
Mohammed El-Hafidi, Martha Franco, Angélica Ruiz Ramírez, José Santamaria Sosa, José Antonio Pineda Flores, Ocarol López Acosta, Monserrath Chávez Salgado, Guillermo Cardoso-Saldaña
Oxidative stress and redox status play a central role in the link between insulin resistance (IR) and lipotoxicity in metabolic syndrome. This mechanistic link may involve alterations in the glutathione redox state. We examined the effect of glycine supplementation to diet on glutathione biosynthesis, oxidative stress, IR, and insulin cell signaling in liver from sucrose-fed (SF) rats characterized by IR and oxidative stress. Our hypothesis is that the correction of glutathione levels by glycine treatment leads to reduced oxidative stress, a mechanism associated with improved insulin signaling and IR...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29675098/baseline-metabolic-risk-score-and-postsurgical-esophageal-cancer-specific-mortality-the-fujian-prospective-investigation-of-cancer-fiesta-study
#18
Hong Sha, Dan Hu, Sinan Wu, Feng Peng, Guodong Xu, Guohui Fan, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
Backgrounds : Compelling evidence has emerged to support a close relationship between metabolic syndrome and esophageal cancer (EC). Aims : Using five baseline metabolism-related markers, we constructed a metabolic risk score (MRS), aiming to test whether MRS can improve the prediction of postsurgical EC-specific mortality over traditional demographic and clinicopathologic characteristics. Methods : Total 2535 EC patients who received three-field lymphadenectomy were enrolled from January 2000 to December 2010, and they were followed up until December 2015...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29674506/diagnostic-and-prognostic-roles-of-circulating-exosomal-micrornas-in-acquired-aplastic-anemia-and-myelodysplastic-syndromes
#19
Valentina Giudice, Lauren G Banaszak, Fernanda Gutierrez-Rodrigues, Sachiko Kajigaya, Reema Panjwani, Maria Del Pilar Fernandez Ibanez, Olga Rios, Christopher K Bleck, Erin S Stempinski, Diego Quinones Raffo, Danielle M Townsley, Neal S Young
Exosomal microRNAs modulate cancer cell metabolism and the immune response. Specific exosomal microRNAs have been reported to be reliable biomarkers of several solid and hematologic malignancies. We examined the possible diagnostic and prognostic values of exosomal microRNAs in two human bone marrow failure diseases, aplastic anemia and myelodysplastic syndromes. After screening of 372 microRNAs in a discovery set (n=42) of plasma exosome samples, we constructed a custom microRNA PCR plate, including 42 microRNAs, for validation in a larger cohort (n=99), and we identified 25 differentially expressed exosomal microRNAs uniquely or frequently present in aplastic anemia and/or myelodysplastic syndromes...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29673944/liver-disease-in-men-undergoing-androgen-deprivation-therapy-for-prostate-cancer
#20
Philipp Gild, Alexander P Cole, Anna Krasnova, Barbra A Dickerman, Nicolas von Landenberg, Maxine Sun, Lorelei A Mucci, Stuart R Lipsitz, Felix K-H Chun, Paul L Nguyen, Adam S Kibel, Toni K Choueiri, Shehzad Basaria, Quoc-Dien Trinh
PURPOSE: Androgen deprivation therapy is associated with development of diabetes and metabolic syndrome. Its effect on developing non-alcoholic fatty liver disease, a condition frequently co-occuring with metabolic syndrome, and other subsequent liver conditions (liver cirrhosis, hepatic necrosis, any liver disease) has not been investigated.
 MATERIALS & METHODS: We identified 82,938 men aged 66 and older diagnosed with localized prostate cancer within the Surveillance, Epidemiology and End Results- Medicare database, 1992-2009...
April 16, 2018: Journal of Urology
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