Yijie Li, Brittney O Baumert, Elizabeth Costello, Jiawen Carmen Chen, Sarah Rock, Nikos Stratakis, Jesse Goodrich, Yinqi Zhao, Sandrah P Eckel, Douglas I Walker, Damaskini Valvi, Michele A La Merrill, Rob McConnell, Victoria K Cortessis, Max Aung, Haotian Wu, Andrea Baccarelli, David Conti, Lida Chatzi
BACKGROUND: Persistent organic pollutants (POPs) are chemicals characterized by their environmental persistence. Evidence suggests that exposure to POPs, which is ubiquitous, is associated with microRNA (miRNA) dysregulation. miRNA are key regulators in many physiological processes. It is thus of public health concern to understand the relationships between POPs and miRNA as related to health outcomes. OBJECTIVES: This systematic review evaluated the relationship between widely recognized, intentionally manufactured, POPs, including per- and polyfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB]), with miRNA expression in both human and animal studies...
December 4, 2023: Environmental Research