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Growth and development

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https://www.readbyqxmd.com/read/28449458/lower-expression-of-platelet-derived-growth-factor-is-associated-with-better-overall-survival-rate-of-patients-with-idiopathic-nonspecific-interstitial-pneumonia
#1
Xuyou Zhu, Xia Fang, Wei Chen, Fei Han, Ziling Huang, Benfang Luo, Pan Gu, Long Zhang, Weizhe Qiu, Yu Zeng, Weiwei Rui, Xianghua Yi
BACKGROUND: Idiopathic nonspecific interstitial pneumonia (INSIP) presents with varying degrees of interstitial inflammation and fibrosis exhibiting a uniform appearance. Lack of knowledge on the underlying mechanisms of INSIP has contributed to few effective treatment strategies. Our study is designed to explore aberrantly expressed cytokines involvement in INSIP development. METHODS: Oligo GEArray was employed to detect the expression of cytokines in INSIP patients, and idiopathic pulmonary fibrosis (IPF) was setup as isotype control...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449427/trichuris-trichiura-infection-in-north-korean-defector-resulted-in-chronic-abdominal-pain-and-growth-retardation
#2
Jong Bin Kim, Kwang Il Seo, Won Moon
Trichuris trichiura infection is a common helminth infection, which is transmitted via soil, with worldwide distribution, especially in rural areas of developing countries. Occasionally, sporadic cases occur in non-endemic, developed areas due to the widespread of immigration. We experienced a case of Trichuris dysentery syndrome in a young North Korean defector, who had been suffering from chronic abdominal pain for 10 years. He is relatively short and thin compared with his older brother. Unexpectedly, the diagnosis, made by a colonoscopy, revealed numerous, small, white, and gently moving worms at the cecum and ascending colon...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28449398/feeding-induced-phenol-production-in-capsicum-annuum-l-influences-spodoptera-litura-f-larval-growth-and-physiology
#3
Vijaya Movva, Usha Rani Pathipati
We studied the role of induced plant phenols as a defense response to insect herbivory. Phenolic compounds were induced in Capsicum annuum L., the source of many culinary peppers, after feeding by different stages of the insect pest, Spodoptera litura F. The phenols were identified and quantified using high performance liquid chromatography (HPLC) and effects produced by these phenols on larval development were studied. Vanillic acid was identified in plants challenged by second, fourth, and fifth instar larvae, but not in plants challenged by third instar nor unchallenged plants...
May 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/28449068/development-of-a-novel-human-recellularized-endometrium-that-responds-to-a-28-day-hormone-treatment
#4
Susan A Olalekan, Joanna E Burdette, Spiro Getsios, Teresa K Woodruff, J Julie Kim
Three dimensional (3D) in vitro models have been established to study the physiology and pathophysiology of the endometrium. With emerging evidence that the native extracellular matrix (ECM) provides appropriate cues and growth factors essential for tissue homeostasis, we describe, a novel 3D endometrium in vitro model developed from decellularized human endometrial tissue repopulated with primary endometrial cells. Analysis of the decellularized endometrium using mass spectrometry analysis revealed an enrichment of cell adhesion molecules, cytoskeletal proteins and ECM proteins such as Collagen IV and Laminin...
April 25, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28449056/plant-hexokinases-are-multifaceted-proteins
#5
Giovanna P Aguilera-Alvarado, Sobeida Sánchez-Nieto
Sugars are the main carbon and energy source in cells, but they can also act as signaling molecules that affect the whole plant life cycle. Certain tissues can produce sugars and supply them to others, and this plant tissue heterogeneity makes sugar signaling a highly complex process that requires elements capable of perceiving changes in sugar concentrations among different tissues, cell compartments and developmental stages. In plants, the regulatory effects of Glucose (Glc) have been the most studied to date...
April 25, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28448993/the-long-non-coding-rna-xist-controls-non-small-cell-lung-cancer-proliferation-and-invasion-by-modulating-mir-186-5p
#6
Haoyou Wang, Qiming Shen, Xin Zhang, Chunlu Yang, Su Cui, Yanbin Sun, Liming Wang, Xiaoxi Fan, Shun Xu
BACKGROUND/AIMS: Long non-coding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript) has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however, its role and molecular mechanisms in NSCLC cell progression remain unclear. METHODS: qRT-PCR was conducted to assess the expression of XIST and miR-186. Cell proliferation was detected using MTT assay. Cell invasion and migration were evaluated using transwell assay...
April 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28448983/intrauterine-growth-restriction-alters-the-postnatal-development-of-the-rat-cerebellum
#7
Annie R A McDougall, Vanny Wiradjaja, Aminath Azhan, Anqi Li, Nadia Hale, Mary E Wlodek, Stuart B Hooper, Megan J Wallace, Mary Tolcos
Intrauterine growth restriction (IUGR) is a major cause of antenatal brain injury. We aimed to characterize cerebellar deficits following IUGR and to investigate the potential underlying cellular and molecular mechanisms. At embryonic day 18, pregnant rats underwent either sham surgery (controls; n = 23) or bilateral uterine vessel ligation to restrict blood flow to fetuses (IUGR; n = 20). Offspring were collected at postnatal day 2 (P2), P7, and P35. Body weights were reduced at P2, P7, and P35 in IUGR offspring (p < 0...
April 28, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28448960/utility-of-genomic-analysis-in-differentiating-synchronous-and-metachronous-lung-adenocarcinomas-from-primary-adenocarcinomas-with-intrapulmonary-metastasis
#8
Jad Saab, Hamid Zia, Susan Mathew, Michael Kluk, Navneet Narula, Helen Fernandes
Distinguishing synchronous and metachronous primary lung adenocarcinomas from adenocarcinomas with intrapulmonary metastasis is essential for optimal patient management. In this study, multiple lung adenocarcinomas occurring in the same patient were evaluated using comprehensive histopathologic evaluation supplemented with molecular analysis. The cohort included 18 patients with a total of 52 lung adenocarcinomas. Eleven patients had a new diagnosis of multiple adenocarcinomas in the same lobe (n=5) or different lobe (n=6)...
April 24, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28448948/interactions-between-the-vascular-endothelial-growth-factor-gene-polymorphism-and-life-events-in-susceptibility-to-major-depressive-disorder-in-a-chinese-population
#9
Dong Han, Zhengxue Qiao, Lu Chen, Xiaohui Qiu, Deyu Fang, Xiuxian Yang, Jingsong Ma, Mingqi Chen, Jiarun Yang, Lin Wang, Xiongzhao Zhu, Congpei Zhang, Yanjie Yang, Hui Pan
BACKGROUND: Recent studies suggest that vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder. The aim of this study is to investigate the interaction between vascular endothelial growth factor (VEGF) polymorphism (+405G/C, rs2010963) and negative life events in the pathogenesis of major depressive disorder (MDD). METHODS: DNA genotyping was performed on peripheral blood leukocytes in 274 patients with MDD and 273 age-and sex-matched controls...
April 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28448910/exposure-to-2-2-4-4-tetrabromodiphenyl-ether-at-late-gestation-modulates-placental-signaling-molecules-in-the-mouse-model
#10
Yun Zhu, Yan Qin Tan, Lai K Leung
Polybrominated diphenyl ethers (PBDEs) are flame retardants generally employed in manufacturing household items. Surface water may remove and carry these chemicals to the drainage upon disposal of the items, and ultimately the chemicals enter our food chain. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) is a PBDE congener commonly found in contaminated seafood. The placenta is the site of nutrient exchange and is responsible for reproductive hormone secretion during pregnancy. In the present study, pregnant ICR mice were given p...
April 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448908/biological-impacts-of-glyphosate-on-morphology-embryo-biomechanics-and-larval-behavior-in-zebrafish-danio-rerio
#11
Shuhui Zhang, Jia Xu, Xiangyu Kuang, Shibao Li, Xiang Li, Dongyan Chen, Xin Zhao, Xizeng Feng
All of these days, residues of herbicides such as glyphosate are widely distributed in the environment. The ubiquitous use of glyphosate has drawn extensive attention to its toxicity as an organic pollutant. In this study, we employed larval zebrafish as an animal model to evaluate the effect of different concentrations of glyphosate on early development via morphological, biomechanics, behavioral and physiological analyses. Morphological results showed that an obvious delay occurred in the epiboly process and body length, eye and head area were reduced at concentrations higher than 10 mg/L...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448801/the-placental-factor-in-spontaneous-preterm-birth-in-twin-vs-singleton-pregnancies
#12
Eran Weiner, Ann Dekalo, Ohad Feldstein, Elad Barber, Letizia Schreiber, Jacob Bar, Michal Kovo
OBJECTIVE: The association between infection and inflammatory response in singleton preterm birth (PTB) is well established, yet, less is known about PTB in twins. We aimed to compare the placental component and pregnancy outcome in pregnancies complicated with PTB of singletons vs. twin deliveries. We hypothesized that due to different underlying mechanisms, placental inflammatory lesions will be more prevalent in placentas derived from singleton pregnancies than twins. STUDY DESIGN: Labor characteristics, neonatal outcome and placental histopathology reports of spontaneous PTB at 24-33(6)/7 weeks, from 1/2008-12/2015, were reviewed...
April 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28448785/a-class-ii-myosin-is-required-for-growth-conidiation-cell-wall-integrity-and-pathogenicity-of-magnaporthe-oryzae
#13
Min Guo, Leyong Tan, Xiang Nie, Zhengguang Zhang
In eukaryotic organisms, myosin proteins are the major ring components that are involved in cytokinesis. To date, little is known about the biological functions of myosin proteins in Magnaporthe oryzae. In this study, insertional mutagenesis conducted in M. oryzae led to identification of Momyo2, a pathogenicity gene predicted to encode a class-II myosin protein homologous to Saccharomyces cerevisiae Myo1. According to qRT-PCR, Momyo2 is highly expressed during early infectious stage. When this gene was disrupted, the resultant mutant isolates were attenuated in virulence on rice and barley...
April 27, 2017: Virulence
https://www.readbyqxmd.com/read/28448686/plasma-cytokines-associated-with-febrile-status-epilepticus-in-children-a-potential-biomarker-for-acute-hippocampal-injury
#14
William B Gallentine, Shlomo Shinnar, Dale C Hesdorffer, Leon Epstein, Douglas R Nordli, Darrell V Lewis, L Matthew Frank, Syndi Seinfeld, Ruth C Shinnar, Karen Cornett, Binyi Liu, Solomon L Moshé, Shumei Sun
OBJECTIVE: Our aim was to explore the association between plasma cytokines and febrile status epilepticus (FSE) in children, as well as their potential as biomarkers of acute hippocampal injury. METHODS: Analysis was performed on residual samples of children with FSE (n = 33) as part of the Consequences of Prolonged Febrile Seizures in Childhood study (FEBSTAT) and compared to children with fever (n = 17). Magnetic resonance imaging (MRI) was obtained as part of FEBSTAT within 72 h of FSE...
April 27, 2017: Epilepsia
https://www.readbyqxmd.com/read/28448624/overexpression-of-the-protein-phosphatase-2a-regulatory-subunit-a-gene-zmpp2aa1-improves-low-phosphate-tolerance-by-remodeling-the-root-system-architecture-of-maize
#15
Jiemin Wang, Laming Pei, Zhe Jin, Kewei Zhang, Juren Zhang
Phosphate (Pi) limitation is a constraint for plant growth and development in many natural and agricultural ecosystems. In this study, a gene encoding Zea mays L. protein phosphatase 2A regulatory subunit A, designated ZmPP2AA1, was induced in roots by low Pi availability. The function of the ZmPP2AA1 gene in maize was analyzed using overexpression and RNA interference. ZmPP2AA1 modulated root gravitropism, negatively regulated primary root (PR) growth, and stimulated the development of lateral roots (LRs)...
2017: PloS One
https://www.readbyqxmd.com/read/28448583/characterization-of-the-fecal-microbiome-during-neonatal-and-early-pediatric-development-in-puppies
#16
Blake C Guard, Hanna Mila, Jörg M Steiner, Claire Mariani, Jan S Suchodolski, Sylvie Chastant-Maillard
Limited information is available describing the development of the neonatal fecal microbiome in dogs. Feces from puppies were collected at 2, 21, 42, and 56 days after birth. Feces were also collected from the puppies' mothers at a single time point within 24 hours after parturition. DNA was extracted from fecal samples and 454-pyrosequencing was used to profile 16S rRNA genes. Species richness continued to increase significantly from 2 days of age until 42 days of age in puppies. Furthermore, microbial communities clustered separately from each other at 2, 21, and 42 days of age...
2017: PloS One
https://www.readbyqxmd.com/read/28448559/hexa-is-a-versatile-regulator-involved-in-the-control-of-phenotypic-heterogeneity-of-photorhabdus-luminescens
#17
Angela Langer, Adriana Moldovan, Christian Harmath, Susan A Joyce, David J Clarke, Ralf Heermann
Phenotypic heterogeneity in microbial communities enables genetically identical organisms to behave differently even under the same environmental conditions. Photorhabdus luminescens, a bioluminescent Gram-negative bacterium, contains a complex life cycle, which involves a symbiotic interaction with nematodes as well as a pathogenic association with insect larvae. P. luminescens exists in two distinct phenotypic cell types, designated as the primary (1°) and secondary (2°) cells. The 1° cells are bioluminescent, pigmented and can support nematode growth and development...
2017: PloS One
https://www.readbyqxmd.com/read/28448470/auxiliary-truncated-unscented-kalman-filtering-for-bearings-only-maneuvering-target-tracking
#18
Liang-Qun Li, Xiao-Li Wang, Zong-Xiang Liu, Wei-Xin Xie
Novel auxiliary truncated unscented Kalman filtering (ATUKF) is proposed for bearings-only maneuvering target tracking in this paper. In the proposed algorithm, to deal with arbitrary changes in motion models, a modified prior probability density function (PDF) is derived based on some auxiliary target characteristics and current measurements. Then, the modified prior PDF is approximated as a Gaussian density by using the statistical linear regression (SLR) to estimate the mean and covariance. In order to track bearings-only maneuvering target, the posterior PDF is jointly estimated based on the prior probability density function and the modified prior probability density function, and a practical algorithm is developed...
April 27, 2017: Sensors
https://www.readbyqxmd.com/read/28448452/a-wireless-sensor-network-for-growth-environment-measurement-and-multi-band-optical-sensing-to-diagnose-tree-vigor
#19
Shinichi Kameoka, Shuhei Isoda, Atsushi Hashimoto, Ryoei Ito, Satoru Miyamoto, Genki Wada, Naoki Watanabe, Takashi Yamakami, Ken Suzuki, Takaharu Kameoka
We have tried to develop the guidance system for farmers to cultivate using various phenological indices. As the sensing part of this system, we deployed a new Wireless Sensor Network (WSN). This system uses the 920 MHz radio wave based on the Wireless Smart Utility Network that enables long-range wireless communication. In addition, the data acquired by the WSN were standardized for the advanced web service interoperability. By using these standardized data, we can create a web service that offers various kinds of phenological indices as secondary information to the farmers in the field...
April 27, 2017: Sensors
https://www.readbyqxmd.com/read/28448328/hospice-or-community-network-choices-in-end-of-life-care-in-jamaica
#20
Roger Lee Mendoza
AIM: National and international healthcare agencies and organizations typically attribute slow or haphazard growth in hospice and palliative care in developing countries to various resource constraints. This study provides evidence of the substantial and widening gap between policy advocacy and individual decision-making concerning end-of-life care. It does so by establishing the incentives and risks that underlie choices of patients and providers against the relative scarcity of hospices in these countries...
April 26, 2017: International Journal of Evidence-based Healthcare
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