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Environmental toxicology

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https://www.readbyqxmd.com/read/28319722/bisphenol-s-exposure-modulate-macrophage-phenotype-as-defined-by-cytokines-profiling-global-metabolomics-and-lipidomics-analysis
#1
Chao Zhao, Zhi Tang, Jiacheng Yan, Jing Fang, Hailin Wang, Zongwei Cai
As an important structural analogue of bisphenol A (BPA), bisphenol S (BPS) has been used as alternatives to BPA in industrialized production. However, the immunotoxicity of BPS remains poorly understood. As a critical model in inflammatory responses, macrophages are used to explore the immunotoxic potential and mechanisms of BPS at environmentally relevant concentrations in our study. Here, we are combining molecular toxicology and mass spectrometry (MS)-based global metabolomics and lipidomics study together to estimate the variation of cytokines profiling and metabolism characteristic following BPS exposure...
March 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28303741/weight-of-the-evidence-evaluation-of-2-4-d-potential-for-interactions-with-the-estrogen-androgen-and-thyroid-pathways-and-steroidogenesis
#2
B H Neal, J Bus, M S Marty, K Coady, A Williams, J Staveley, J C Lamb
A comprehensive weight-of-the-evidence evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) was conducted for potential interactions with the estrogen, androgen and thyroid pathways and with steroidogenesis. This assessment was based on an extensive database of high quality in vitro, in vivo ecotoxicological and in vivo mammalian toxicological studies. Epidemiological studies were also considered. Toxicokinetic data provided the basis for determining rational cutoffs above which exposures were considered irrelevant to humans based on exceeding thresholds for saturation of renal clearance (TSRC); extensive human exposure and biomonitoring data support that these boundaries far exceed human exposures and provide ample margins of exposure...
March 2, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28303633/cobalt-chloride-exposure-dose-dependently-induced-hepatotoxicity-through-enhancement-of-cyclooxygenase-2-cox-2-b-cell-associated-protein-x-bax-signaling-and-genotoxicity-in-wistar-rats
#3
Omolola Victoria Awoyemi, Ufuoma Jowafe Okotie, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Ebunoluwa Racheal Asenuga, Olufunke Eunice Ola-Davies, Blessing Seun Ogunpolu
Cobalt chloride (CoCl2 ) is one of the many environmental contaminants, used in numerous industrial sectors. It is a pollutant with deadly toxicological consequences both in developing and developed countries. We investigated toxicological impact of CoCl2 on hepatic antioxidant status, apoptosis, and genotoxicity. Forty Wistar rats were divided into four groups, 10 rats per group: Group 1 served as control and received clean tap water orally; Group 2 received CoCl2 solution (150 mg/L); Group 3 received CoCl2 solution (300 mg/L); and Group 4 received CoCl2 (600 mg/L) in drinking water for 7 days, respectively...
March 17, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28299394/caenorhabditis-elegans-as-a-powerful-alternative-model-organism-to-promote-research-in-genetic-toxicology-and-biomedicine
#4
REVIEW
Sebastian Honnen
In view of increased life expectancy the risk for disturbed integrity of genetic information increases. This inevitably holds the implication for higher incidence of age-related diseases leading to considerable cost increase in health care systems. To develop preventive strategies it is crucial to evaluate external and internal noxae as possible threats to our DNA. Especially the interplay of DNA damage response (DDR) and DNA repair (DR) mechanisms needs further deciphering. Moreover, there is a distinct need for alternative in vivo test systems for basic research and also risk assessment in toxicology...
March 15, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28294984/defining-the-baseline-and-oxidant-perturbed-lipidomic-profiles-of-daphnia-magna
#5
Nadine S Taylor, Thomas A White, Mark R Viant
Recent technological advancement has enabled the emergence of lipidomics as an important tool for assessing molecular stress, one which has yet to be assessed fully as an approach in an environmental toxicological context. Here we have applied a high-resolution, non-targeted, nanoelectrospray ionisation (nESI) direct infusion mass spectrometry (DIMS) technique to assess the effects of oxidative stress to Daphnia magna both in vitro (air exposure of daphniid extracts) and in vivo (Cu(2+) exposure). Multivariate and univariate statistical analyses were used to distinguish any perturbations including oxidation to the D...
March 15, 2017: Metabolites
https://www.readbyqxmd.com/read/28292241/microbial-pest-control-agents-are-they-a-specific-and-safe-tool-for-insect-pest-management
#6
Caroline Deshayes, Myriam Siegwart, David Pauron, Josy-Anne Froger, Bruno Lapied, Véronique Apaire-Marchais
Microorganisms (viruses, bacteria and fungi) or their bioactive agents can be used as active substances and therefore are referred as Microbial Pest Control Agents (MPCA). They are used as alternative strategies to chemical insecticides to counteract the development of resistances and to reduce adverse effects on both environment and human health. These natural entomopathogenic agents, which have specific modes of action, are generally considered safer as compared to conventional chemical insecticides. Baculoviruses are the only viruses being used as the safest biological control agents...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28286084/recent-experimental-results-of-effects-of-perfluoroalkyl-substances-in-laboratory-animals-relation-to-current-regulations-and-guidance-values
#7
Hellmuth Lilienthal, Hermann H Dieter, Jürgen Hölzer, Michael Wilhelm
The detection of perfluoroalkyl substances (PFAS) in surface and drinking water from various countries raised the attention to the presence of these chemicals in environmental probes and led to several regulatory actions to limit exposure in human beings. There was particular concern about perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), due to their former wide-spread use. Recently, several institutions published revisions of former regulatory or recommended maximum concentrations in drinking water and food, which are markedly lower than the former values...
March 2, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28285553/carbon-nanopowder-acts-as-a-trojan-horse-for-benzo-%C3%AE-pyrene-in-danio-rerio-embryos
#8
A Binelli, L Del Giacco, N Santo, L Bini, S Magni, M Parolini, L Madaschi, A Ghilardi, D Maggioni, M Ascagni, A Armini, L Prosperi, C Landi, C La Porta, C Della Torre
Carbon-based nanoparticles are largely distributed worldwide due to fossil fuel combustion and their presence in many consumer products. In addition to their proven toxicological effects in several biological models, attention in recent years has focused on the role played by carbon-based nanoparticles as Trojan-horse carriers for adsorbed environmental pollutants. This role has not been conclusively determined to date because carbon-based nanoparticles can decrease the bioavailability of contaminants or represent an additional source of intake...
March 13, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28284552/mussels-as-bioindicators-of-diclofenac-contamination-in-coastal-environments
#9
S C Cunha, A Pena, J O Fernandes
Diclofenac a nonsteroidal anti-inflammatory drug (NSAID) has been confirmed as an emerging contaminant in the aquatic environment. Toxicology studies have revealed that harmful effects may emerge from diclofenac presence not only for human health, but also for marine organisms, which implies its monitoring. To overcome the demanding challenges of diclofenac quantification in biotic aquatic species, a novel method for the determination of diclofenac in mussels (Mytilus galloprovincialis and Mytilus edulis) and macroalgae (Laminaria digitata) using high performance liquid chromatography coupled to tandem mass spectrometry was developed and validated according to the EC Decision 2002/657/EC...
March 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28284375/toward-a-comprehensive-hypothesis-of-chronic-interstitial-nephritis-in-agricultural-communities
#10
REVIEW
Carlos Manuel Orantes-Navarro, Raúl Herrera-Valdés, Miguel Almaguer-López, Laura López-Marín, Xavier Fernando Vela-Parada, Marcelo Hernandez-Cuchillas, Lilly M Barba
Over the past 20 years, there has been an increase in chronic interstitial nephritis in agricultural communities (CINAC) not associated with traditional risk factors. This disease has become an important public health problem and is observed in several countries in Central America and Asia. CINAC predominantly affects young male farmers between the third and fifth decades of life with women, children, and adolescents less often affected. Clinically, CINAC behaves like a chronic tubulointerstitial nephropathy but with systemic manifestations not attributable to kidney disease...
March 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28282620/a-3d-fish-liver-model-for-aquatic-toxicology-morphological-changes-and-cyp1a-induction-in-plhc-1-microtissues-after-repeated-benzo-a-pyrene-exposures
#11
April L Rodd, Norma J Messier, Charles A Vaslet, Agnes B Kane
To identify the potential environmental impacts of aquatic pollutants, rapid and sensitive screening tools are needed to assess adaptive and toxic responses. This study characterizes a novel fish liver microtissue model, produced with the cell line PLHC-1, as an in vitro aquatic toxicity testing platform. These 3D microtissues remain viable and stable throughout the 8-day testing period and relative to 2D monolayers, show increased basal expression of the xenobiotic metabolizing enzyme cytochrome P450 1A (Cyp1a)...
February 21, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28279175/the-mouse-mammary-gland-as-a-sentinel-organ-distinguishing-control-populations-with-diverse-environmental-histories
#12
SriDurgaDevi Kolla, Aastha Pokharel, Laura N Vandenberg
BACKGROUND: There are numerous examples of laboratory animals that were inadvertently exposed to endocrine disrupting chemicals (EDCs) during the process of conducting experiments. Controlling contaminations in the laboratory is challenging, especially when their source is unknown. Unfortunately, EDC contaminations can interfere with the interpretation of data during toxicological evaluations. We propose that the male CD-1 mouse mammary gland is a sensitive bioassay to evaluate the inadvertent contamination of animal colonies...
March 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28277036/toxicology-of-metals-and-metalloids-promising-issues-for-future-studies-in-environmental-health-and-toxicology
#13
Fernando Barbosa
The function and behavior of chemical elements in ecosystems and in human health probably comprise one of the most studied issues and a theme of great interest and fascination in science. Hot topics are emerging on an annual basis in this field. Bearing this in mind, some promising themes to explore in the field of metals and metalloids in the environment and in toxicology are highlighted and briefly discussed herein.
February 17, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28274593/in-depth-compositional-analysis-of-water-soluble-and-insoluble-organic-substances-in-fine-pm2-5-airborne-particles-using-ultra-high-resolution-15t-ft-icr-ms-and-gc%C3%A3-gc-tofms
#14
Jung Hoon Choi, Jijeong Ryu, Sodam Jeon, Jungju Seo, Yung-Hun Yang, Seung Pil Pack, Sungwook Choung, Kyoung-Soon Jang
Airborne particulate matter consisting of ionic species, salts, heavy metals and carbonaceous material is one of the most serious environmental pollutants owing to its impacts on the environment and human health. Although elemental and organic carbon compounds are known to be major components of aerosols, information on the elemental composition of particulate matter remains limited because of the broad range of compounds involved and the limits of analytical instruments. In this study, we investigated water-soluble and -insoluble organic compounds in fine (PM2...
March 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28271507/establishment-and-characterization-of-a-cell-line-from-the-head-kidney-of-golden-pompano-trachinotus-ovatus-and-its-application-in-toxicology-and-virus-susceptibility
#15
P Li, L Zhou, S Wei, M Yang, S Ni, Y Yu, J Cai, Q Qin
A cell line derived from the head kidney of golden pompano Trachinotus ovatus (TOHK) was established and characterized in this study. The TOHK cells grew most rapidly at 28° C and the optimum foetal bovine serum concentration in L-15 medium was 10%. The TOHK cells have a diploid chromosome number of 2N = 54. The transfection efficiency of TOHK cells was 7·5% at the 15th passage and 72% at the 40th passage. The transfection efficiency in TOHK cells was high, so these cells are suitable for foreign gene expression...
March 8, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28266262/using-exposure-bands-for-rapid-decision-making-in-the-risk21-tiered-exposure-assessment
#16
M Dellarco, R Zaleski, B J Gaborek, H Qian, C A Bellin, P Egeghy, N Heard, O Jolliet, D R Lander, N Sunger, K S Stylianou, J Y Tanir
The ILSI Health and Environmental Sciences Institute (HESI) Risk Assessment in the Twenty-first Century (RISK21) project was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent evaluation of both hazard and exposure components. The RISK21 roadmap is exposure-driven, that is, exposure is used as the second step (after problem formulation) to define and focus the assessment...
February 10, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28263526/bioindicators-of-wastewater-ecotoxicity
#17
Gabriela Jirova, Zdenka Wittlingerova, Magdalena Zimova, Alena Vlkova, Martina Wittlerova, Marketa Dvorakova, Dagmar Jirova
Wastewater, especially containing hospital effluents, exhibits high chemical complexity and specificity since it includes various chemicals, biocides, pharmaceuticals, surfactants, radionuclides, disinfectants and pathogens. Biological tests provide true evidence of the wastewater quality and unlike chemical analytical tests show comprehensive pollution effects on the environment and human health. Normalized conventional bioassays are not sensitive enough for ecotoxicological evaluation of wastewater and there is a great need for the development of suitable sensitive bioassays in order to characterize properly the residual toxicity of treated effluents...
December 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28262329/toxicological-impacts-of-antibiotics-on-aquatic-micro-organisms-a-mini-review
#18
REVIEW
Pia Välitalo, Antonina Kruglova, Anna Mikola, Riku Vahala
Antibiotics are found globally in the environment at trace levels due to their extensive consumption, which raises concerns about the effects they can have on non-target organisms, especially environmental micro-organisms. So far the majority of studies have focused on different aspects of antibiotic resistance or on analyzing the occurrence, fate, and removal of antibiotics from hospital and municipal wastewaters. Little attention has been paid to ecotoxicological effects of antibiotics on aquatic micro-organisms although they play a critical role in most ecosystems and they are potentially sensitive to these substances...
February 22, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28259702/in-vitro-cardiotoxicity-assessment-of-environmental-chemicals-using-an-organotypic-human-induced-pluripotent-stem-cell-derived-model
#19
Oksana Sirenko, Fabian A Grimm, Kristen R Ryan, Yasuhiro Iwata, Weihsueh A Chiu, Frederick Parham, Jessica A Wignall, Blake Anson, Evan F Cromwell, Mamta Behl, Ivan Rusyn, Raymond R Tice
An important target area for addressing data gaps through in vitro screening is the detection of potential cardiotoxicants. Despite the fact that current conservative estimates relate at least 23% of all cardiovascular disease cases to environmental exposures, the identities of the causative agents remain largely uncharacterized. Here, we evaluate the feasibility of a combinatorial in vitro/in silico screening approach for functional and mechanistic cardiotoxicity profiling of environmental hazards using a library of 69 representative environmental chemicals and drugs...
March 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28258433/examining-predictors-of-chemical-toxicity-in-freshwater-fish-using-the-random-forest-technique
#20
Baigal-Amar Tuulaikhuu, Helena Guasch, Emili García-Berthou
Chemical pollution is one of the main issues globally threatening the enormous biodiversity of freshwater ecosystems. The toxicity of substances depends on many factors such as the chemical itself, the species affected, environmental conditions, exposure duration, and concentration. We used the random forest technique to examine the factors that mediate toxicity in a set of widespread fishes and analyses of covariance to further assess the importance of differential sensitivity among fish species. Among 13 variables, the 5 most important predictors of toxicity with random forests were, by order of importance, the chemical substance itself (i...
March 3, 2017: Environmental Science and Pollution Research International
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