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Endocrine disruption

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https://www.readbyqxmd.com/read/28447138/-endocrine-disruptors-evidence-from-epidemiological-studies-necessitates-a-critical-review-of-model-systems
#1
REVIEW
M Hoffmann, S Gebauer, M Nüchter, R Baber, J Ried, M von Bergen, W Kiess
Endocrine disruptive chemicals (EDCs) cause adverse health effects through interaction with endocrine systems. They are classified by chemical structure, effects on specific endocrine systems, bioaccumulation, persistence in the environment, or clinically observable effects. For research of the complex mechanisms of action in the human body, only in vitro model systems have so far been available, that have insufficient high-throughput capacity, which makes risk evaluation more difficult. In addition, in industrial nations, living people are often exposed to mixtures of substances, with various effects...
April 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28445042/structural-transformation-of-mno2-during-the-oxidation-of-bisphenol-a
#2
Sarah Balgooyen, Peter J Alaimo, Christina K Remucal, Matthew Ginder-Vogel
Bisphenol A (BPA) is an endocrine-disrupting compound widely used in the plastic industry and found in natural waters at concentrations considered harmful for aquatic life. BPA is susceptible to oxidation by Mn(III/IV) oxides, which are commonly found in near-surface environments. Here, we quantify BPA oxidation rates and the formation of its predominant product, 4-hydroxycumyl alcohol (HCA), in tandem with transformation of a synthetic, Mn(III)-rich δ-MnO2. To investigate the effect of Mn oxide structural changes on BPA oxidation rate, twelve sequential additions of 80 μM BPA are performed at pH 7...
April 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28444106/the-association-of-air-pollution-with-pubertal-development-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#3
Jian V Huang, Gabriel M Leung, C Mary Schooling
Many pollutants are endocrine disruptors with impacts on reproduction and health in animals, but evidence in humans, of which sex-specific effects on pubertal development may be an indicator, is less clear. We examined the association of air pollution in utero and during early life with pubertal development in Hong Kong, China, an area with a high level of air pollution compared with other similarly developed cities. We assessed sex-specific associations of particulate matter less than or equal to 10 μm in diameter (PM10), nitric oxide, sulfur dioxide, and nitrogen dioxide in different growth phases with clinically assessed pubertal stage at approximately age 11 years (as indicated by Tanner stage) in a large population-representative birth cohort, the "Children of 1997...
April 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28441746/high-performance-prediction-of-human-estrogen-receptor-agonists-based-on-chemical-structures
#4
Yuki Asako, Yoshihiro Uesawa
Many agonists for the estrogen receptor are known to disrupt endocrine functioning. We have developed a computational model that predicts agonists for the estrogen receptor ligand-binding domain in an assay system. Our model was entered into the Tox21 Data Challenge 2014, a computational toxicology competition organized by the National Center for Advancing Translational Sciences. This competition aims to find high-performance predictive models for various adverse-outcome pathways, including the estrogen receptor...
April 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28439012/gestational-bisphenol-a-exposure-lowers-the-threshold-for-autoimmunity-in-a-model-of-multiple-sclerosis
#5
James A Rogers, Manoj K Mishra, Jennifer Hahn, Catherine J Greene, Robin M Yates, Luanne M Metz, V Wee Yong
Environmental and hormonal factors are implicated in dysimmunity in multiple sclerosis. We investigated whether bisphenol-A, a prominent contaminant with endocrine-disrupting capabilities, altered susceptibility in an inflammatory model of multiple sclerosis. We found that gestational, but not adult, exposure to bisphenol-A increased the development of experimental autoimmune encephalomyelitis in adulthood in male, but not female, mice when a suboptimal disease-inducing immunization was used. Gestational bisphenol-A in male mice primed macrophages in adulthood and raised granulocyte-colony stimulating factor and neutrophil counts/activity postsuboptimal immunization...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28437741/use-of-nuclear-receptor-luciferase-based-bioassays-to-detect-endocrine-active-chemicals-in-a-biosolids-biochar-amended-soil
#6
Carolyn G Anderson, Geetika Joshi, Daniel A Bair, Charlotte Oriol, Guochun He, Sanjai J Parikh, Michael S Denison, Kate M Scow
Biosolids are a potentially valuable source of carbon and nutrients for agricultural soils; however, potential unintended impacts on human health and the environment must be considered. Virtually all biosolids contain trace amounts endocrine-disrupting chemicals derived from human use of pharmaceuticals and personal care products (PPCPs). One potential way to reduce the bioavailability of PPCPs is to co-apply biosolids with biochar to soil, because biochar's chemical (e.g., aromaticity) and physical properties (e...
April 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28434584/how-does-sex-matter-behavior-stress-and-animal-models-of-neurobehavioral-disorders
#7
REVIEW
Paola Palanza, Stefano Parmigiani
Many aspects of brain functioning exhibit important sex differences that affect behavior, mental health and mental disorders. However, most translational neuroscience research related to animal models of neurobehavioral disorders are carried out in male animals only. Based on published data from our laboratory on the House mouse, we discuss the following issues: (1) sex differences in social behavior of wild-derived mice; (2) artificial selection of laboratory strains and its consequences on social and reproductive competition; (3) sex-dependent effects of common experimental procedures; (4) differential effects of developmental events: the case of endocrine disruption; (5) implications for female models of stress and neurobehavioral disorders...
May 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28432637/polluted-pathways-mechanisms-of-metabolic-disruption-by-endocrine-disrupting-chemicals
#8
REVIEW
Mizuho S Mimoto, Angel Nadal, Robert M Sargis
PURPOSE OF REVIEW: Environmental toxicants are increasingly implicated in the global decline in metabolic health. Focusing on diabetes, herein, the molecular and cellular mechanisms by which metabolism disrupting chemicals (MDCs) impair energy homeostasis are discussed. RECENT FINDINGS: Emerging data implicate MDC perturbations in a variety of pathways as contributors to metabolic disease pathogenesis, with effects in diverse tissues regulating fuel utilization...
April 21, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28431277/endocrine-disruption-by-environmental-gestagens-in-amphibians-a-short-review-supported-by-new-in%C3%A2-vitro-data-using-gonads-of-xenopus-laevis
#9
REVIEW
Andrea Ziková, Claudia Lorenz, Frauke Hoffmann, Wibke Kleiner, Ilka Lutz, Matthias Stöck, Werner Kloas
Endocrine disruption caused by various anthropogenic compounds is of persisting concern, especially for aquatic wildlife, because surface waters are the main sink of these so-called endocrine disruptors (ED). In the past, research focused on (anti)estrogenic, (anti)androgenic, and (anti)thyroidal substances, affecting primarily reproduction and development in vertebrates; however, other endocrine systems might be also targeted by ED. Environmental gestagens, including natural progestogens (e.g. progesterone (P4)) and synthetic progestins used for contraception, are supposed to affect vertebrate reproduction via progesterone receptors...
April 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28430429/potential-glucocorticoid-and-mineralocorticoid-effects-of-nine-organophosphate-flame-retardants
#10
Quan Zhang, Jinghua Wang, Jianqiang Zhu, Jing Liu, Meirong Zhao
Organophosphate flame retardants (OPFRs), as alternatives of polybrominated diphenyl ethers (PBDEs), have been frequently detected in the environment and biota, and could pose adverse effects on organisms. However, information on the potential endocrine disruption of OPFRs, especially their effects on steroid hormone receptors, such as glucocorticoid and mineralocorticoid receptors (GR/MR), is limited. In this study, the dual-luciferase reporter gene assay via GR/MR and a H295R steroidogenesis assay were employed to evaluate the endocrine disruption of nine OPFRs...
April 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28426875/bisphenol-a-activates-egfr-and-erk-promoting-proliferation-tumor-spheroid-formation-and-resistance-to-egfr-pathway-inhibition-in-estrogen-receptor-negative-inflammatory-breast-cancer-cells
#11
Scott J Sauer, Michael Tarpley, Imran Shah, Akshay V Save, H Kim Lyerly, Steven R Patierno, Kevin P Williams, Gayathri R Devi
Emerging evidence from epidemiological studies suggests a link between environmental chemical exposure and progression of aggressive breast cancer subtypes. Of all clinically distinct types of breast cancers, the most lethal phenotypic variant is inflammatory breast cancer (IBC). Overexpression of epidermal growth factor receptors (EGFR/HER2) along with estrogen receptor (ER) negativity is common in IBC tumor cells, which instead of a solid mass present as rapidly proliferating diffuse tumor cell clusters. Our previous studies have demonstrated a role of an adaptive response of increased antioxidants in acquired resistance to EGFR-targeting drugs in IBC...
March 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28426724/cloning-retinoid-and-peroxisome-proliferator-activated-nuclear-receptors-of-the-pacific-oyster-and-in-silico-binding-to-environmental-chemicals
#12
Susanne Vogeler, Tamara S Galloway, Michail Isupov, Tim P Bean
Disruption of nuclear receptors, a transcription factor superfamily regulating gene expression in animals, is one proposed mechanism through which pollution causes effects in aquatic invertebrates. Environmental pollutants have the ability to interfere with the receptor's functions through direct binding and inducing incorrect signals. Limited knowledge of invertebrate endocrinology and molecular regulatory mechanisms, however, impede the understanding of endocrine disruptive effects in many aquatic invertebrate species...
2017: PloS One
https://www.readbyqxmd.com/read/28414904/in-silico-prediction-of-chemicals-binding-to-aromatase-with-machine-learning-methods
#13
Hanwen Du, Yingchun Cai, Hongbin Yang, Hongxiao Zhang, Yuhan Xue, Guixia Liu, Yun Tang, Weihua Li
Environmental chemicals may affect endocrine systems through multiple mechanisms, one of which is via effects on aromatase (also known as CYP19A1), an enzyme critical for maintaining the normal balance of estrogens and androgens in the body. Therefore, rapid and efficient identification of aromatase-related endocrine disrupting chemicals (EDCs) is important for toxicology and environment risk assessment. In this study, on the basis of the Tox21 10K compound library, in silico classification models for predicting aromatase binders/nonbinders were constructed by machine learning methods...
April 26, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28412309/the-scaffold-protein-rack1-is-a-target-of-endocrine-disrupting-chemicals-edcs-with-important-implication-in-immunity
#14
Erica Buoso, Marilisa Galasso, Melania Ronfani, Angela Papale, Valentina Galbiati, Ivano Eberini, Marina Marinovich, Marco Racchi, Emanuela Corsini
We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may also be targeted by endocrine disrupting chemicals (EDCs). As a proof of concept, we investigated the effect of the doping agent nandrolone, an androgen receptor (AR) agonist, and of p,p'DDT (dichlorodiphenyltrichloroethane) and its main metabolite p,p'DDE (dichlorodiphenyldichloroethylene), a weak and strong AR antagonist, respectively, on RACK1 expression and innate immune response...
April 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28411869/detection-of-endocrine-disrupting-chemicals-and-evidence-of-their-effects-on-the-hpg-axis-of-the-european-anchovy-engraulis-encrasicolus
#15
Andrea Miccoli, Francesca Maradonna, Andrea De Felice, Vincenzo Caputo Barucchi, Andone Estonba, Michele Genangeli, Sauro Vittori, Iole Leonori, Oliana Carnevali
Natural/synthetic Endocrine Disrupting Chemicals (EDCs) may display estrogenic activity and a lower potency than 17β-estradiol. Nonetheless, their concentrations and additive effects can affect the endocrine system and reproductive processes related to the Hypothalamic-Pituitary-Gonadal (HPG) axis. Because of their persistence in both the environment and biological systems, they ultimately target multi-level predators, including humans. We detected presence and effects of xenobiotics on wild anchovy Engraulis encrasicolus in the Western Adriatic Sea...
April 5, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28411819/an-electrochemical-bisphenol-a-sensor-based-on-one-step-electrochemical-reduction-of-cuprous-oxide-wrapped-graphene-oxide-nanoparticles-modified-electrode
#16
Rongguang Shi, Jing Liang, Zongshan Zhao, Aifeng Liu, Yong Tian
Bisphenol A (BPA), as an important industrial material, has been widespread concerned in recent years as its endocrine disrupting effect. This study reported a novel bisphenol A sensor via a facile one step electrochemical reduction of graphene oxide (rGO) and cuprous oxide (Cu2O) nanocomposite modified glassy carbon electrodes. The characterization of the fabricated sensor was performed by scanning electron microscopy and X-ray spectroscopy. The prepared Cu2O-rGO electrode presented fast response, high sensitivity and low background current...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411469/primary-hepatocytes-from-arctic-char-salvelinus-alpinus-as-a-relevant-arctic-in-vitro-model-for-screening-contaminants-and-environmental-extracts
#17
Karina Petersen, Maria T Hultman, Knut Erik Tollefsen
Contaminants find their way to the Arctic through long-range atmospheric transport, transport via ocean currents, and through increased anthropogenic activity. Some of the typical pollutants reaching the Arctic (PAHs, PCBs) are known to induce cytochrome P450 1a (CYP1A) protein expression and ethoxyresorufin-O-deethylase (EROD) activity through the aryl hydrocarbon receptor (AhR). In addition, some endocrine disrupting chemicals (EDCs) such as estrogen mimics (xenoestrogens) have been documented in Arctic areas and they may interfere with natural sexual development and reproduction...
April 2, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28411468/nine-co-localized-cytochrome-p450-genes-of-the-cyp2n-cyp2ad-and-cyp2p-gene-families-in-the-mangrove-killifish-kryptolebias-marmoratus-genome-identification-and-expression-in-response-to-b-%C3%AE-p-bpa-op-and-np
#18
Jayesh Puthumana, Bo-Mi Kim, Chang-Bum Jeong, Duck-Hyun Kim, Hye-Min Kang, Jee-Hyun Jung, Il-Chan Kim, Un-Ki Hwang, Jae-Seong Lee
The CYP2 genes are the largest and most diverse cytochrome P450 (CYP) subfamily in vertebrates. We have identified nine co-localized CYP2 genes (∼55kb) in a new cluster in the genome of the highly resilient ecotoxicological fish model Kryptolebias marmoratus. Molecular characterization, temporal and tissue-specific expression pattern, and response to xenobiotics of these genes were examined. The CYP2 gene clusters were characterized and designated CYP2N22-23, CYP2AD12, and CYP2P16-20. Gene synteny analysis confirmed that the cluster in K...
March 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28411467/different-transcriptomic-responses-of-two-marine-copepods-tigriopus-japonicus-and-pseudodiaptomus-annandalei-to-a-low-dose-of-mercury-chloride-hgcl2
#19
Minghua Wang, Chang-Bum Jeong, Yan Li, Jae-Seong Lee
Mercury (Hg) pollution is a ubiquitous and serious concern in marine environments, but the response mechanisms of marine animals to Hg pollution (i.e., toxicity/tolerance) are poorly understood. To compare the global responses of two marine copepods (Tigriopus japonicus and Pseudodiaptomus annandalei), we analyzed whole transcriptomes using RNA-seq technology in response to Hg treatment (a nominal 10μg/L HgCl2 in seawater) for 5h. Hg was strikingly accumulated in both copepods under treatment. The Hg concentration in P...
March 24, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28411449/prenatal-concentrations-of-perfluoroalkyl-substances-and-early-communication-development-in-british-girls
#20
Zuha Jeddy, Terryl J Hartman, Ethel V Taylor, Cayla Poteete, Katarzyna Kordas
Perfluoroalkyl substances (PFAS), found in many household products and classed as endocrine disrupting chemicals, can be transferred through the placenta and are associated with multiple developmental deficits in offspring. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we investigated the association between intrauterine exposure to PFAS and early communication development in 432 mother-daughter dyads at 15 and 38months of age. Concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) were measured in maternal serum collected during pregnancy...
April 12, 2017: Early Human Development
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