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Endocrine disruption

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https://www.readbyqxmd.com/read/28941401/effect-based-assessment-of-toxicity-removal-during-wastewater-treatment
#1
Pia Välitalo, Riccardo Massei, Ilse Heiskanen, Peter Behnisch, Werner Brack, Andrew J Tindall, David Du Pasquier, Eberhard Küster, Anna Mikola, Tobias Schulze, Markus Sillanpää
Wastewaters contain complex mixtures of chemicals, which can cause adverse toxic effects in the receiving environment. In the present study, the toxicity removal during wastewater treatment at seven municipal wastewater treatment plants (WWTPs) was investigated using an effect-based approach. A battery of eight bioassays was applied comprising of cytotoxicity, genotoxicity, endocrine disruption and fish embryo toxicity assays. Human cell-based CALUX assays, transgenic larval models and the fish embryo toxicity test were particularly sensitive to WWTP effluents...
September 7, 2017: Water Research
https://www.readbyqxmd.com/read/28938483/varying-susceptibility-of-the-female-mammary-gland-to-in-utero-windows-of-bpa-exposure
#2
Andrea R Hindman, Xiaokui Molly Mo, Hannah L Helber, Claire E Kovalchin, Nanditha Ravichandran, Alina R Murphy, Abigail M Fagan, Pamela M St John, Craig J Burd
In utero exposure to the endocrine disrupting compound bisphenol A (BPA) is known to disrupt mammary gland development and increase tumor susceptibility in rodents. It is unclear if there are different periods of in utero development that may be more susceptible to BPA exposure. Herein, pregnant CD-1 mice were exposed to BPA at different times during gestation that correspond to specific milestones of in utero mammary gland development. Mammary glands of early-life and adult female mice, exposed in utero to BPA, were morphologically and molecularly (ERα and Ki67) evaluated for developmental abnormalities...
August 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938452/dose-specific-effects-of-di-isononyl-phthalate-on-the-endocannabinoid-system-and-on-liver-of-female-zebrafish
#3
Isabel Forner-Piquer, Francesca Maradonna, Giorgia Gioacchini, Stefania Santangeli, Marco Allarà, Fabiana Piscitelli, Hamid R Habibi, Vincenzo Di Marzo, Oliana Carnevali
Phthalates, used as plasticizers, have become a ubiquitous contaminant and have been reported for their potential to induce toxicity in living organisms. Among them, the Di-isononyl phthalate (DiNP) has been recently used to replace the bis(2-ethylhexyl) phthalate (DEHP). Nowadays, there is evidence that DiNP is an Endocrine Disrupting Chemical (EDC), however little is known about its effects on the Endocannabinoid System (ECS) and lipid metabolism. Hence, the aim of our study was to investigate the effects of DiNP on the ECS in zebrafish liver and brain and on hepatic lipid storage...
August 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938450/sex-specific-modulation-of-fetal-adipogenesis-by-gestational-bisphenol-a-and-bisphenol-s-exposure
#4
Yong Pu, Jeremy Gingrich, Juan P Steibel, Almudena Veiga-Lopez
The endocrine disrupting chemical bisphenol A (BPA) increases adipose tissue mass in vivo and promotes adipogenesis in vitro. However, mechanisms explaining BPA's obesogenic effect remain unknown. We investigated the effects of gestational BPA and its analogue, bisphenol S (BPS), exposure on the adipogenic differentiation ability of fetal preadipocytes and the role of endoplasmic reticulum stress in regulating this process. Pregnant sheep (n=7-8/group) mated to the same male were exposed to BPA or BPS from days 30 to 100 of gestation, and pregnancies terminated 20 days later...
September 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28937960/prenatal-exposure-to-nonpersistent-endocrine-disruptors-and-behavior-in-boys-at-3-and-5-years
#5
Claire Philippat, Dorothy Nakiwala, Antonia M Calafat, Jérémie Botton, Maria De Agostini, Barbara Heude, Rémy Slama
BACKGROUND: Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. OBJECTIVES: We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants. METHODS: We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy...
September 15, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28936697/reactive-oxygen-species-and-glutathione-antioxidants-in-the-testis-of-the-soil-biosentinel-podarcis-sicula-rafinesque-1810
#6
Giulia Guerriero, Gerardino D'Errico, Rossella Di Giaimo, Dea Rabbito, Oladokun Sulaiman Olanrewaju, Gaetano Ciarcia
Important toxicological achievements have been made during the last decades using reptiles. We focus our investigation on gonadal reproductive health of the soil biosentinel Podarcis sicula which is very sensitive to endocrine-disrupting chemicals. The aim of this study is to quantitatively detect, by sensitive microassays, reactive oxygen species and the glutathione antioxidants in the testis and investigate if they are differentially expressed before and after remediation of a site of the "Land of Fires" (Campania, Italy) subject to illicit dumping of unknown material...
September 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28936609/a-hierarchical-testing-strategy-for-micropollutants-in-drinking-water-regarding-their-potential-endocrine-disrupting-effects-towards-health-related-indicator-values
#7
Jochen Kuckelkorn, Regine Redelstein, Timon Heide, Jennifer Kunze, Sibylle Maletz, Petra Waldmann, Tamara Grummt, Thomas-Benjamin Seiler, Henner Hollert
In Germany, micropollutants that (may) occur in drinking water are assessed by means of the health-related indicator value (HRIV concept), developed by the German Federal Environment Agency. This concept offers five threshold values (≤ 0.01 to ≤ 3 μg l(-1)) depending on availability and completeness of data regarding genotoxicity, neurotoxicity, and germ cell-damaging potential. However, the HRIV concept is yet lacking integration of endocrine disruptors as one of the most prominent toxicological concerns in water bodies, including drinking water...
September 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28936425/gut-dysbiosis-in-animals-due-to-environmental-chemical-exposures
#8
REVIEW
Cheryl S Rosenfeld
The gut microbiome consists of over 10(3)-10(4) microorganism inhabitants that together possess 150 times more genes that the human genome and thus should be considered an "organ" in of itself. Such communities of bacteria are in dynamic flux and susceptible to changes in host environment and body condition. In turn, gut microbiome disturbances can affect health status of the host. Gut dysbiosis might result in obesity, diabetes, gastrointestinal, immunological, and neurobehavioral disorders. Such host diseases can originate due to shifts in microbiota favoring more pathogenic species that produce various virulence factors, such as lipopolysaccharide...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28935616/endocrine-disruptors-and-health-effects-in-africa-a-call-for-action
#9
Maria S Bornman, Natalie H Aneck-Hahn, Christiaan de Jager, Gesina M Wagenaar, Hindrik Bouwman, Irene E J Barnhoorn, Sean M Patrick, Laura N Vandenberg, Andreas Kortenkamp, Bruce Blumberg, Sarah Kimmins, Bernard Jegou, Jacques Auger, Joseph DiGangi, Jerrold J Heindel
BACKGROUND: Africa faces a number of unique environmental challenges. Unfortunately, it lacks the infrastructure needed to support the comprehensive environmental studies that could provide the scientific basis to inform environmental policies. There are a number of known sources of endocrine-disrupting chemicals (EDCs) and other hazardous chemicals in Africa. However, a coordinated approach to identify and monitor these contaminants and to develop strategies for public health interventions has not yet been made...
August 22, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934723/neural-mechanisms-underlying-the-disruption-of-male-courtship-behavior-by-adult-exposure-to-di-2-ethylhexyl-phthalate-in-mice
#10
Carlos Dombret, Daphné Capela, Kevin Poissenot, Caroline Parmentier, Emma Bergsten, Cédric Pionneau, Solenne Chardonnet, Hélène Hardin-Pouzet, Valérie Grange-Messent, Matthieu Keller, Isabelle Franceschini, Sakina Mhaouty-Kodja
BACKGROUND: Courtship behavior plays a critical role in attracting females and reproduction success. However, the effects of exposure to a ubiquitous contaminant di(2-ethylhexyl) phthalate (DEHP) on these behaviors and, in particular, on courtship vocalizations have not been examined. OBJECTIVE: The effects of adult exposure to DEHP on courtship and mating behaviors and gonadotropic axis and neural mechanisms involved in DEHP-induced effects were analyzed in male mice...
September 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934718/urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#11
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28929406/pharmacopollution-and-household-waste-medicine-hwm-how-reverse-logistics-is-environmentally-important-to-brazil
#12
André Luiz Pereira, Raphael Tobias de Vasconcelos Barros, Sandra Rosa Pereira
Pharmacopollution is a public health and environmental outcome of some active pharmaceutical ingredients (API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are the pharmaceutical industry, healthcare facilities (e.g., hospitals), livestock, aquaculture, and households (patients' excretion and littering). The last source is the focus of this article. Research questions are "What is the Household Waste Medicine (HWM) phenomenon?", "How HWM and pharmacopollution are related?", and "Why is a reverse logistic system necessary for HWM in Brazil?" This article followed the seven steps proposed by Rother (2007) for a systematic review based on the Cochrane Handbook and the National Health Service (NHS) Center for Reviews Dissemination (CDR) Report...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929288/complex-organic-pollutant-mixtures-originating-from-industrial-and-municipal-emissions-in-surface-waters-of-the-megacity-jakarta-an-example-of-a-water-pollution-problem-in-emerging-economies
#13
Larissa Dsikowitzky, Lukas Hagemann, Dwiyitno, Farida Ariyani, Hari Eko Irianto, Jan Schwarzbauer
During the last decades, the global industrial production partly shifted from industrialized nations to emerging and developing countries. In these upcoming economies, the newly developed industrial centers are generally located in densely populated areas, resulting in the discharge of often only partially treated industrial and municipal wastewaters into the surface waters. There is a huge gap of knowledge about the composition of the complex organic pollutant mixtures occurring in such heavily impacted areas...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929027/the-role-of-polycarbonate-monomer-bisphenol-a-in-insulin-resistance
#14
Milos Pjanic
Bisphenol A (BPA) is a synthetic unit of polycarbonate polymers and epoxy resins, the types of plastics that could be found in essentially every human population and incorporated into almost every aspect of the modern human society. BPA polymers appear in a wide range of products, from liquid storages (plastic bottles, can and glass linings, water pipes and tanks) and food storages (plastics wraps and containers), to medical and dental devices. BPA polymers could be hydrolyzed spontaneously or in a photo- or temperature-catalyzed process, providing widespread environmental distribution and chronic exposure to the BPA monomer in contemporary human populations...
2017: PeerJ
https://www.readbyqxmd.com/read/28924161/molecular-mechanisms-involved-in-the-non-monotonic-effect-of-bisphenol-a-on-ca2-entry-in-mouse-pancreatic-%C3%AE-cells
#15
Sabrina Villar-Pazos, Juan Martinez-Pinna, Manuel Castellano-Muñoz, Paloma Alonso-Magdalena, Laura Marroqui, Ivan Quesada, Jan-Ake Gustafsson, Angel Nadal
In regulatory toxicology, the dose-response relationship is a key element towards fulfilling safety assessments and satisfying regulatory authorities. Conventionally, the larger the dose, the greater the response, following the dogma "the dose makes the poison". Many endocrine disrupting chemicals, including bisphenol-A (BPA), induce non-monotonic dose response (NMDR) relationships, which are unconventional and have tremendous implications in risk assessment. Although several molecular mechanisms have been proposed to explain NMDR relationships, they are largely undemonstrated...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922976/transient-impairment-of-islet-architectural-development-in-pancreas-specific-bmpr1a-deleted-prenatal-mice-involves-reduced-expression-of-e-cadherin
#16
Fang-Xu Jiang, Leonard Charles Harrison
Bone morphogenetic protein (BMP) signaling plays critical roles on the development of a large array of embryonic organs and promotes the in vitro formation of pancreatic cystoid colonies containing insulin-producing cells. However, this signaling and its underlying mechanism on in vivo development of prenatal pancreas have not been clearly understood. To address these questions, we analyzed with a variety of techniques the prenatal mouse pancreas after Pdx1 (the pancreas and duodenal homeobox factor 1 gene)-driving deletion of the BMP receptor type 1a gene (Bmpr1a)...
September 19, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28920512/rhythmic-three-part-harmony-the-complex-interaction-of-maternal-placental-and-fetal-circadian-systems
#17
Peter J Mark, Rachael C Crew, Michaela D Wharfe, Brendan J Waddell
From the perspective of circadian biology, mammalian pregnancy presents an unusual biological scenario in which an entire circadian system (i.e., that of the fetus) is embodied within another (i.e., that of the mother). Moreover, both systems are likely to be influenced at their interface by a third player, the placenta. Successful pregnancy requires major adaptations in maternal physiology, many of which involve circadian changes that support the high metabolic demands of the growing fetus. A functional role for maternal circadian adaptations is implied by the effects of circadian disruption, which result in pregnancy complications including higher risks for miscarriage, preterm labor, and low birth weight...
September 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28918339/interference-of-dibutylphthalate-on-human-prostate-cell-viability
#18
Mariana Di Lorenzo, Maurizio Forte, Salvatore Valiante, Vincenza Laforgia, Maria De Falco
Dibutylphthalate (DBP) is an environmental pollutant widely used as plasticizer in a variety of industrial applications worldwide. This agent can be found in personal-care products, children's toy, pharmaceuticals, food products. Exposure to DBP can occur via ingestion and inhalation as well as intravenous or skin contact. DBP belongs to the family of endocrine disrupting chemicals (EDCs) and its effects on reproductive system were demonstrated both in vivo and in vitro. In the present study we evaluated the effects of DBP on human prostate adenocarcinoma epithelial cells (LNCaP) in order to highlight xenoestrogens influence on human prostate...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918287/steroid-hormones-and-persistent-organic-pollutants-in-plasma-from-north-eastern-atlantic-pilot-whales
#19
Katrin S Hoydal, Bjarne Styrishave, Tomasz M Ciesielski, Robert J Letcher, Maria Dam, Bjørn M Jenssen
Persistent organic pollutants (POPs) are known to have endocrine disruptive effects, interfering with endogenous steroid hormones. The present study examined nine steroid hormones and their relationships with the concentrations of selected POPs in pilot whales (Globicephala melas) from the Faroe Islands, NE Atlantic. The different steroids were detected in 15 to all of the 26 individuals. High concentrations of progesterone (83.3-211.7pmol/g) and pregnenolone (PRE; 4.68-5.69pmol/g) were found in three adult females indicating that they were pregnant or ovulating...
September 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28918279/seasonal-variation-of-chloro-s-triazines-in-the-hartbeespoort-dam-catchment-south-africa
#20
Cornelius Rimayi, David Odusanya, Jana M Weiss, Jacob de Boer, Luke Chimuka
Seasonal variation of eight chloro-s-triazine herbicides and seven major atrazine and terbuthylazine degradation products was monitored in the Hartbeespoort Dam catchment using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS/MS). Lake, river and groundwater were sampled from the Hartbeespoort Dam catchment over four seasons and the downstream Jukskei River was monitored during the winter season. Triazine herbicide concentrations in the Hartbeespoort Dam were in the order atrazine>simazine>propazine>ametryn>prometryn throughout the four seasons sampled...
September 14, 2017: Science of the Total Environment
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