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Endocrine disruption

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https://www.readbyqxmd.com/read/28345956/modulation-of-steroidogenesis-by-vitamin-d3-in-granulosa-cells-of-the-mouse-model-of-polycystic-ovarian-syndrome
#1
Shabnam Bakhshalizadeh, Fardin Amidi, Ashraf Alleyassin, Masoud Soleimani, Reza Shirazi, Maryam Shabani Nashtaei
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age characterized by polycystic ovarian morphology, anovulation or oligomenorrhea, and hyperandrogenism. It is shown that disruption in the steroidogenesis pathway caused by excess androgen in PCOS is a critical element of abnormal folliculogenesis and failure in dominant follicle selection. Vitamin D plays an important role in the regulation of ovulatory dysfunction and can influence genes involved in steroidogenesis in granulosa cells...
March 27, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28341988/unexpected-differences-between-planar-and-column-liquid-chromatographic-retention-of-1-acenaphthenol-enantiomers-controlled-by-supramolecular-interactions-involving-%C3%AE-cyclodextrin-at-subambient-temperatures
#2
Hatsuichi Ohta, Elżbieta Włodarczyk, Krzysztof Piaskowski, Aleksandra Kaleniecka, Lucyna Lewandowska, Michał J Baran, Mariusz Wojnicz, Kiyokatsu Jinno, Yoshihiro Saito, Paweł K Zarzycki
We report the results of experimental work focusing on host-guest supramolecular complex creation between macrocyclic compound (β-cyclodextrin) and 1-acenaphthenol enantiomers (racemic mixture) in liquid phase composed of 35% acetonitrile in water (v/v) at different temperatures ranging from 0 to 90 °C. Experimental setup involved several analytical protocols based on classical non-forced flow planar chromatography (RP-18 TLC plates), micro-TLC (RP-18 W HPTLC plates), column chromatography (HPLC with C-18 and C-30 stationary phases), as well as UV-Vis spectrophotometry and optical microscopy...
March 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28341464/reproductive-effects-of-oestrogenic-endocrine-disrupting-chemicals-in-astyanax-rivularis-inhabiting-headwaters-of-the-velhas-river-brazil
#3
André Alberto Weber, Davidson Peruci Moreira, Rafael Magno Costa Melo, Augusto Bicalho Cruz Vieira, Paula Suzanna Prado, Mirra Angelina Neres da Silva, Nilo Bazzoli, Elizete Rizzo
The Velhas River is the most polluted river in the state of Minas Gerais, south-eastern Brazil. Due to its historical and environmental relevance, the aim of this study was to evaluate the effects of oestrogenic endocrine disruptors on the reproduction of the lambari Astyanax rivularis, a small-sized species found in headwaters of the São Francisco River basin. Quarterly field samplings were carried out during a reproductive cycle in three streams of the upper Velhas River: S1 (reference site) and S2 and S3 (sites contaminated by untreated sewage)...
March 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28340478/different-dna-damage-response-of-cis-and-trans-isomers-of-commonly-used-uv-filter-after-the-exposure-on-adult-human-liver-stem-cells-and-human-lymphoblastoid-cells
#4
Anežka Sharma, Katarína Bányiová, Pavel Babica, Naouale El Yamani, Andrew Richard Collins, Pavel Čupr
2-ethylhexyl 4-methoxycinnamate (EHMC), used in many categories of personal care products (PCPs), is one of the most discussed ultraviolet filters because of its endocrine-disrupting effects. EHMC is unstable in sunlight and can be transformed from trans-EHMC to emergent cis-EHMC. Toxicological studies are focusing only on trans-EHMC; thus the toxicological data for cis-EHMC are missing. In this study, the in vitro genotoxic effects of trans- and cis-EHMC on adult human liver stem cells HL1-hT1 and human-derived lymphoblastoid cells TK-6 using a high-throughput comet assay were studied...
March 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28340460/interactions-between-three-typical-endocrine-disrupting-chemicals-edcs-in-binary-mixtures-exposure-on-myocardial-differentiation-of-mouse-embryonic-stem-cell
#5
Ren Zhou, Wei Cheng, Yan Feng, Hongying Wei, Fan Liang, Yan Wang
In recent years, various kinds of endocrine-disrupting chemicals (EDCs) have been detected in human blood and urine. Thus, it was important to investigate the combined toxicity effect of EDCs. In the present study, we evaluated the individual and combined developmental toxicities of three classic EDCs: perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and bisphenol A (BPA) by embryonic stem cell test (EST). The similarities and differences between combination of same chemical group as well as different chemical groups were investigated in this research...
March 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28336389/metformin-ameliorates-uterine-defects-in-a-rat-model-of-polycystic-ovary-syndrome
#6
Yuehui Zhang, Min Hu, Fanci Meng, Xiaoyan Sun, Hongfei Xu, Jiao Zhang, Peng Cui, Njomeza Morina, Xin Li, Wei Li, Xiao-Ke Wu, Mats Brännström, Ruijin Shao, Håkan Billig
Adult rats treated concomitantly with insulin and human chorionic gonadotropin exhibit endocrine, metabolic, and reproductive abnormalities that are very similar to those observed in polycystic ovary syndrome (PCOS) patients. In this study, we used this rat model to assess the effects of metformin on PCOS-related uterine dysfunction. In addition to reducing androgen levels, improving insulin sensitivity, and correcting the reproductive cycle, metformin treatment induced morphological changes in the PCOS-like uterus...
March 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28333377/circadian-rhythms-in-adipose-tissue-physiology
#7
Jana-Thabea Kiehn, Anthony H Tsang, Isabel Heyde, Brinja Leinweber, Isa Kolbe, Alexei Leliavski, Henrik Oster
The different types of adipose tissues fulfill a wide range of biological functions-from energy storage to hormone secretion and thermogenesis-many of which show pronounced variations over the course of the day. Such 24-h rhythms in physiology and behavior are coordinated by endogenous circadian clocks found in all tissues and cells, including adipocytes. At the molecular level, these clocks are based on interlocked transcriptional-translational feedback loops comprised of a set of clock genes/proteins. Tissue-specific clock-controlled transcriptional programs translate time-of-day information into physiologically relevant signals...
March 16, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28331572/environmental-risk-factors-for-autism-an-evidence-based-review-of-systematic-reviews-and-meta-analyses
#8
REVIEW
Amirhossein Modabbernia, Eva Velthorst, Abraham Reichenberg
BACKGROUND: According to recent evidence, up to 40-50% of variance in autism spectrum disorder (ASD) liability might be determined by environmental factors. In the present paper, we conducted a review of systematic reviews and meta-analyses of environmental risk factors for ASD. We assessed each review for quality of evidence and provided a brief overview of putative mechanisms of environmental risk factors for ASD. FINDINGS: Current evidence suggests that several environmental factors including vaccination, maternal smoking, thimerosal exposure, and most likely assisted reproductive technologies are unrelated to risk of ASD...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28329833/thy1-cd90-expression-is-reduced-by-the-environmental-chemical-tetrabromobisphenol-a-to-promote-adipogenesis-through-induction-of-microrna-103
#9
Collynn F Woeller, E'Lissa Flores, Stephen J Pollock, Richard P Phipps
Environmental chemicals termed "obesogens" disrupt the endocrine system to promote adipogenesis and obesity. Tetrabromobisphenol-A (TBBPA) has been reported to increase adipogenesis, however, the mechanism(s) of action are unclear. Thy1 (CD90) is a glycophosphatidylinositol (GPI) -anchored membrane protein that serves as a marker for stem cells and also plays an important role in regulating adipogenesis and obesity. We investigated whether or not TBBPA promotes adipogenesis in human and mouse cells by reducing Thy1 levels...
February 22, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28327540/endocrine-disrupting-chemicals-and-endometrial-cancer-an-overview-of-recent-laboratory-evidence-and-epidemiological-studies
#10
REVIEW
Maddalena Mallozzi, Chiara Leone, Francesca Manurita, Filippo Bellati, Donatella Caserta
Background: Although exposure to endocrine disruptor compounds (EDCs) has been suggested as a contributing factor to a range of women's health disorders including infertility, polycystic ovaries and the early onset of puberty, considerable challenges remain in attributing cause and effect on gynaecological cancer. Until recently, there were relatively few epidemiological studies examining the relationship between EDCs and endometrial cancer, however, in the last years the number of these studies has increased...
March 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28325592/intersexuality-in-aquatic-invertebrates-prevalence-and-causes
#11
REVIEW
Tiago F Grilo, Rui Rosa
This review is the first assembling information on intersexuality in aquatic invertebrates, from freshwater to estuarine and marine environments. Intersex is a condition whereby an individual of a gonochorist (separate sexes) species has oocytes or distinct stages of spermatogonia, at varying degrees of development, within the normal gonad of the opposite gender (i.e. spermatocytes in the ovary or oocytes in the testis), often involving alterations in the gonadal structure, reproductive tract or external genitalia...
March 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28324061/progesterone-protects-against-bpa-induced-arrhythmias-in-female-rat-cardiac-myocytes-via-rapid-signaling
#12
Jianyong Ma, Kui Hong, Hong-Sheng Wang
Bisphenol A (BPA) is an estrogenic endocrine disrupting chemical (EDC) that has a range of potential adverse health effects. Previously we showed that acute exposure to BPA promoted arrhythmias in female rat hearts through estrogen receptor rapid signaling. Progesterone (P4) and estrogen have antagonistic or complementary actions in a number of tissues and systems. In the current study, we examined the influence, and possible protective effect, of P4 on the rapid cardiac actions of BPA in female rat cardiac myocytes...
January 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323920/perinatal-exposure-to-low-dose-bisphenol-a-bpa-disrupts-the-structural-and-functional-development-of-the-hypothalamic-feeding-circuitry
#13
Harry MacKay, Zachary R Patterson, Alfonso Abizaid
Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor due to observations of its estrogenic activity in various experimental models. We have previously shown evidence of disrupted hypothalamic feeding circuitry and leptin sensitivity in adult BPA-exposed animals subject to a high-fat diet, but because these animals were already exhibiting a diet-induced obese phenotype, we could not rule out the possibility that these observations were simply consequences of the obesity, not a pre-existing phenotype produced by BPA exposure...
February 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/28322186/effect-of-isoflurane-anesthesia-on-circadian-metabolism-and-physiology-in-rats
#14
Melissa A Wren-Dail Robert T Dauchy David E Blask Steven M Hill Tara G Ooms Lynell M Dupepe And Rudolf P Bohm
Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism andphysiology and increases stress, but the effect of brief CO2 anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO2 (70% CO2, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague-Dawley rats (Crl:SD; n = 6 per group) were maintained on a 12:12-h light:dark(300 lx; lights on, 0600) photoperiod...
March 20, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28319747/integration-of-in-silico-methods-and-computational-systems-biology-to-explore-endocrine-disrupting-chemical-binding-with-nuclear-hormone-receptors
#15
P Ruiz, A Sack, M Wampole, S Bobst, M Vracko
Thousands of potential endocrine-disrupting chemicals present difficult regulatory challenges. Endocrine-disrupting chemicals can interfere with several nuclear hormone receptors associated with a variety of adverse health effects. The U.S. Environmental Protection Agency (U.S. EPA) has released its reviews of Tier 1 screening assay results for a set of pesticides in the Endocrine Disruptor Screening Program (EDSP), and recently, the Collaborative Estrogen Receptor Activity Prediction Project (CERAPP) data...
March 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319143/toxicity-effects-of-di-2-ethylhexyl-phthalate-to-eisenia-fetida-at-enzyme-cellular-and-genetic-levels
#16
Tingting Ma, Wei Zhou, Li'ke Chen, Longhua Wu, Peter Christie, Haibo Zhang, Yongming Luo
Di-(2-ethylhexyl) phthalate (DEHP) is a dominant phthalic acid ester (PAE) that has aroused public concern due to its resistance to degradation and its toxicity as an endocrine-disrupting compound. Effects of different concentrations of DEHP on Eisenia fetida in spiked natural soil have been studied in the body of the earthworm by means of soil cultivation tests 7, 14, 21 and 28 days after exposure. The results indicated that, in general, superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, metallothionein (MT) content, the expression of heat shock protein 70 (HSP 70) and all the tested geno-toxicity parameters are promoted as time elapses and with increasing concentration of DEHP...
2017: PloS One
https://www.readbyqxmd.com/read/28319018/the-effect-of-elevated-progesterone-levels-before-hcg-triggering-in-modified-natural-cycle-frozen-thawed-embryo-transfer-cycles
#17
Eva R Groenewoud, Nick S Macklon, Ben J Cohlen
Recent studies suggest that elevated late follicular phase progesterone concentrations after ovarian stimulation for IVF may result in embryo-endometrial asynchrony, reducing the chance of successful implantation after fresh embryo transfer. It remains unclear to what extent elevated late follicular phase progesterone levels may occur in unstimulated cycles before frozen-thawed embryo transfer, or what affect they may have on outcomes. In this cohort study, 271 patients randomized to the modified natural cycle arm of a randomized controlled trial comparing two endometrial preparation regimens underwent late follicular phase progesterone and LH testing...
February 28, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28318793/fate-and-mass-balance-of-bisphenol-analogues-in-wastewater-treatment-plants-in-xiamen-city-china
#18
Qian Sun, Yuwen Wang, Yan Li, Muhammad Ashfaq, Lanhua Dai, Xiaoqing Xie, Chang-Ping Yu
Due to the well-known endocrine disrupting ability of bisphenol A (BPA), its production and usage have been regulated. Consequently, other bisphenol analogues (BPs) have been used as the replacement of BPA. Despite their widespread use, few studies have investigated the occurrence and fate of BPs in wastewater treatment plants (WWTPs). In this study, we conducted a city-wide monitoring survey and collected the wastewater and sludge samples from seven WWTPs in Xiamen, China over seven days. The concentrations of dissolved and adsorbed BPs in the influent and effluent, together with the BP concentrations in the sludge were determined...
March 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28318786/modulation-of-the-stress-response-in-wild-fish-is-associated-with-variation-in-dissolved-nitrate-and-nitrite
#19
Tom G Pottinger
Disruption of non-reproductive endocrine systems in wildlife by chemicals has received little attention but represents a potentially significant problem. Nitrate is a major anthropogenic contaminant in the freshwater aquatic environment and has been identified as a potential disrupter of endocrine function in aquatic animals. This study was conducted to investigate the relationship between the function of the neuroendocrine stress axis in fish and inorganic N loading along reaches of rivers receiving cumulative point source and diffuse chemical inputs...
March 15, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28303741/weight-of-the-evidence-evaluation-of-2-4-d-potential-for-interactions-with-the-estrogen-androgen-and-thyroid-pathways-and-steroidogenesis
#20
B H Neal, J Bus, M S Marty, K Coady, A Williams, J Staveley, J C Lamb
A comprehensive weight-of-the-evidence evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) was conducted for potential interactions with the estrogen, androgen and thyroid pathways and with steroidogenesis. This assessment was based on an extensive database of high quality in vitro, in vivo ecotoxicological and in vivo mammalian toxicological studies. Epidemiological studies were also considered. Toxicokinetic data provided the basis for determining rational cutoffs above which exposures were considered irrelevant to humans based on exceeding thresholds for saturation of renal clearance (TSRC); extensive human exposure and biomonitoring data support that these boundaries far exceed human exposures and provide ample margins of exposure...
March 2, 2017: Critical Reviews in Toxicology
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