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https://www.readbyqxmd.com/read/28542335/interventions-that-effectively-target-anopheles-funestus-mosquitoes-could-significantly-improve-control-of-persistent-malaria-transmission-in-south-eastern-tanzania
#1
Emmanuel W Kaindoa, Nancy S Matowo, Halfan S Ngowo, Gustav Mkandawile, Arnold Mmbando, Marcelina Finda, Fredros O Okumu
Malaria is transmitted by many Anopheles species whose proportionate contributions vary across settings. We re-assessed the roles of Anopheles arabiensis and Anopheles funestus, and examined potential benefits of species-specific interventions in an area in south-eastern Tanzania, where malaria transmission persists, four years after mass distribution of long-lasting insecticide-treated nets (LLINs). Monthly mosquito sampling was done in randomly selected households in three villages using CDC light traps and back-pack aspirators, between January-2015 and January-2016, four years after the last mass distribution of LLINs in 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28540444/organochlorine-pesticides-residues-in-human-breast-milk-from-the-middle-governorates-in-jordan-in-2013-2014
#2
Tawfiq M Al Antary, Mahmoud A Alawi, Hussein Estityah, Nizar Haddad
One hundred samples of mother breast milk were gathered from six middle governorates and districts in Jordan in 2013/2014 to monitor Organochlorine pesticides pollutants. The results showed clearly that banned organochlorine pesticides are still detected in the monitored samples in low concentration despite banning of these persistent pollutants in Jordan since 36 years ago. However, the results indicated that 1% of the contaminated samples contained β-HCH, 5% γ-HCH, 3% p,p'-DDD, 2% heptachlor, 45% p,p'-DDE and 3% p,p'-DDT...
May 24, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28536421/assessment-of-tissue-specific-accumulation-elimination-and-toxic-effects-of-dichlorodiphenyltrichloroethanes-ddts-in-carp-through-aquatic-food-web
#3
Shanshan Di, Ruiquan Liu, Zhongnan Tian, Cheng Cheng, Li Chen, Wenjun Zhang, Zhiqiang Zhou, Jinling Diao
Microcosms containing DDT spiked-sediment, Tubifex tubifex and carp (Cyprinus carpio) were constructed to simulate a freshwater system. The accumulation, elimination and toxic effects of DDT (p,p'-DDT, o,p'-DDT), and its metabolites DDD (p,p'-DDD, o,p'-DDD) and DDE (p,p'-DDE, o,p'-DDE) were studied in T. tubifex and carp. Tissue/organ distributions of DDTs were also investigated in carp. The bioaccumulation and elimination of DDT differed in T. tubifex, carp and its tissues/organs. Unimodal or bimodal distributions were observed, and the concentrations of DDT metabolites (DDD and p,p'-DDE) increased over time...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28532594/the-endocrine-disrupting-alkylphenols-and-4-4-ddt-interfere-with-estrogen-conversion-and-clearance-by-mouse-liver-cytosol
#4
Talal El-Hefnawy, Claudia Hernandez, Laura P Stabile
Endocrine disrupting chemicals (EDCs) are ubiquitous compounds known for negative impacts on reproductive functions and for increasing cancer risk. EDCs are believed to cause the harmful effects in part through their inappropriate low-affinity binding to steroid receptors and other possible non-receptor mediated paradigms, however there is a need to further elucidate other mechanisms involving the direct and indirect impact of EDCs on reproductive functions. We examined the metabolism of 17β-estradiol (E2) and estrone (E1) by cell-free hepatic cytosol in the presence of alkylphenols (nonylphenol/NP and 4-tert-octylphenol/tOP), Dichlorodiphenyltrichloroethane (4,4'-DDT) and other EDCs...
May 19, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28528419/a-risk-based-characterization-of-sediment-contamination-by-legacy-and-emergent-contaminants-of-concern-in-coastal-british-columbia-canada
#5
Carmen Morales-Caselles, Jean-Pierre W Desforges, Neil Dangerfield, Peter S Ross
Sediments have long been used to help describe pollution sources, contaminated sites, trends over time, and habitat quality for marine life. We collected surficial sediments from 12 sites at an average seawater depth of 25 m in three near-urban areas of the Salish Sea (British Columbia, Canada) to investigate habitat quality for marine life, including heavily contaminated killer whales. Samples were analyzed using high-resolution instrumentation for a wide variety of congeners of polychlorinated biphenyls (PCBs), polybrominated diphenylethers (PBDEs), hexabromocyclododecane (HBCDD), polybrominated biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans, organochlorine pesticides, and polychlorinated naphthalenes (PCNs)...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28528416/time-trends-of-persistent-organic-pollutants-in-benthic-and-pelagic-indicator-fishes-from-puget-sound-washington-usa
#6
James E West, Sandra M O'Neill, Gina M Ylitalo
We modeled temporal trends in polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and dichlorodiphenyltrichloroethane and its metabolites (DDTs) in two indicator fish species representing benthic and pelagic habitats in Puget Sound, Washington, USA. English sole (Parophrys vetulus, benthic) index sites and larger-scale Pacific herring (Clupea pallasii, pelagic) foraging areas represented a wide range of possible contamination conditions, with sampling locations situated adjacent to watersheds exhibiting high, medium and low development...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28525783/toolset-for-assessment-of-natural-recovery-from-legacy-contaminated-sediment-case-study-of-pallanza-bay-lake-maggiore-italy
#7
Diana Lin, Yeo-Myoung Cho, Amy Oen, Espen Eek, Jake P Tommerdahl, Richard G Luthy
The aim of this study was to develop a toolset that can be used by site managers to assess and monitor natural attenuation processes in sediments contaminated with legacy hydrophobic organic contaminants. The toolset is composed of sediment traps to measure quality and deposition rate of incoming sediment under different hydrodynamic conditions, sediment cores to show trends in sediment bed concentrations over time, and passive samplers attached to a porewater probe frame to assess the mobility of buried contaminants and possible contaminant flux from sediment...
May 12, 2017: Water Research
https://www.readbyqxmd.com/read/28522354/corrigendum-to-differential-effects-of-the-persistent-ddt-metabolite-methylsulfonyl-dde-in-nonstimulated-and-lh-stimulated-neonatal-porcine-leydig-cells-toxicology-and-applied-pharmacology-267-2013-247-255
#8
Cesilie Granum Castellanos, Irene Beate Sørvik, Marte Bruu Tanum, Steven Verhaegen, Ingvar Brandt, Erik Ropstad
No abstract text is available yet for this article.
May 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28497687/eukaryotic-translesion-dna-synthesis-on-the-leading-and-lagging-strands-unique-detours-around-the-same-obstacle
#9
Mark Hedglin, Stephen J Benkovic
During S-phase, minor DNA damage may be overcome by DNA damage tolerance (DDT) pathways that bypass such obstacles, postponing repair of the offending damage to complete the cell cycle and maintain cell survival. In translesion DNA synthesis (TLS), specialized DNA polymerases replicate the damaged DNA, allowing stringent DNA synthesis by a replicative polymerase to resume beyond the offending damage. Dysregulation of this DDT pathway in human cells leads to increased mutation rates that may contribute to the onset of cancer...
May 12, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28494357/biosurfactant-producing-microorganism-pseudomonas-sp-sb-assists-the-phytoremediation-of-ddt-contaminated-soil-by-two-grass-species
#10
Beibei Wang, Qingling Wang, Wuxing Liu, Xiaoyan Liu, Jinyu Hou, Ying Teng, Yongming Luo, Peter Christie
Phytoremediation together with microorganisms may confer the advantages of both phytoremediation and microbial remediation of soils containing organic contaminants. In this system biosurfactants produced by Pseudomonas sp. SB may effectively help to increase the bioavailability of organic pollutants and thereby enhance their microbial degradation in soil. Plants may enhance the rhizosphere environment for microorganisms and thus promote the bioremediation of contaminants. In the present pot experiment study, dichlorodiphenyltrichloroethane (DDT) residues underwent an apparent decline after soil bioremediation compared with the original soil...
April 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/28487067/selective-and-interactive-effects-of-d2-receptor-antagonism-and-positive-allosteric-mglur4-modulation-on-waiting-impulsivity
#11
Sarah N Isherwood, Trevor W Robbins, Janet R Nicholson, Jeffrey W Dalley, Anton Pekcec
BACKGROUND: Metabotropic glutamate receptor 4 (mGluR4) and dopamine D2 receptors are specifically expressed within the indirect pathway neurons of the striato-pallidal-subthalamic pathway. This unique expression profile suggests that mGluR4 and D2 receptors may play a cooperative role in the regulation and inhibitory control of behaviour. We investigated this possibility by testing the effects of a functionally-characterised positive allosteric mGluR4 modulator, 4-((E)-styryl)-pyrimidin-2-ylamine (Cpd11), both alone and in combination with the D2 receptor antagonist eticlopride, on two distinct forms of impulsivity...
May 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28486186/a-review-on-the-application-of-constructed-wetlands-for-the-removal-of-priority-substances-and-contaminants-of-emerging-concern-listed-in-recently-launched-eu-legislation
#12
REVIEW
Ana M Gorito, Ana R Ribeiro, C M R Almeida, Adrián M T Silva
The presence of organic pollutants in the aquatic environment, usually found at trace concentrations (i.e., between ng L(-1) and μg L(-1) or even lower, known as micropollutants), has been highlighted in recent decades as a worldwide environmental concern due to their difficult elimination by conventional water and wastewater treatment processes. The relevant information on constructed wetlands (CWs) and their application for the removal of a specific group of pollutants, 41 organic priority substances/classes of substances (PSs) and 8 certain other substances with environmental quality standards (EQS) listed in Directive 2013/39/EU as well as 17 contaminants of emerging concern (CECs) of the Watch List of Decision 2015/495/EU, is herein reviewed...
May 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28484956/pesticide-survey-in-water-and-suspended-solids-from-the-uruguay-river-basin-argentina
#13
Celia Williman, Martín S Munitz, María I T Montti, María B Medina, Agustín F Navarro, Alicia E Ronco
The Uruguay River is receptor of pollutants, such as pesticides, from agriculture activities along its course. The present study reports concentration levels of organochlorinate, organophosphorus, and other pesticides in water and suspended solids in nine sampling sites of the Uruguay River. Data analyses included principal component analysis (PCA) to assess differences between sampling sites contamination. Most of the tested pesticides were ubiquitous due to the widely use in the chemical control of pests implemented in the region...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28483709/exposure-to-ddt-and-its-metabolites-from-khat-catha-edulis-chewing-consumers-risk-assessment-from-southwestern-ethiopia
#14
Seblework Mekonen, Argaw Ambelu, Belay Negassa, Pieter Spanoghe
Khat (Catha edulis) is one of the most consumed plant in the horn of African countries. However, it is a stimulant plant that has several side effects on the health of consumers. On top of that, the khat leaves used for human consumption are often contain contaminants such as pesticide residues. The present study aims to investigate the level of DDT residue and its metabolites (p'p-DDE, p'p-DDD, o'p-DDT and p'p-DDT) in khat samples and to undertake exposure assessment to consumers. The khat samples were collected from local markets in southwestern Ethiopia...
May 5, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28480022/long-term-continental-changes-in-wing-length-but-not-bill-length-of-a-long-distance-migratory-shorebird
#15
David B Lank, Cailin Xu, Brian A Harrington, Richard I Guy Morrison, Cheri L Gratto-Trevor, Peter W Hicklin, Brett K Sandercock, Paul Allen Smith, Eunbi Kwon, Jennie Rausch, Lisa D Pirie Dominix, Diana J Hamilton, Julie Paquet, Sydney E Bliss, Sarah G Neima, Christian Friis, Scott A Flemming, Alexandra M Anderson, Ronald C Ydenberg
We compiled a >50-year record of morphometrics for semipalmated sandpipers (Calidris pusilla), a shorebird species with a Nearctic breeding distribution and intercontinental migration to South America. Our data included >57,000 individuals captured 1972-2015 at five breeding locations and three major stopover sites, plus 139 museum specimens collected in earlier decades. Wing length increased by ca. 1.5 mm (>1%) prior to 1980, followed by a decrease of 3.85 mm (nearly 4%) over the subsequent 35 years...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28477266/combination-of-multiple-neural-crest-migration-assays-to-identify-environmental-toxicants-from-a-proof-of-concept-chemical-library
#16
Johanna Nyffeler, Xenia Dolde, Alice Krebs, Kevin Pinto-Gil, Manuel Pastor, Mamta Behl, Tanja Waldmann, Marcel Leist
Many in vitro tests have been developed to screen for potential neurotoxicity. However, only few cell function-based tests have been used for comparative screening, and thus experience is scarce on how to confirm and evaluate screening hits. We addressed these questions for the neural crest cell migration test (cMINC). After an initial screen, a hit follow-up strategy was devised. A library of 75 compounds plus internal controls (NTP80-list), assembled by the National Toxicology Program of the USA (NTP) was used...
May 5, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28476008/breast-milk-intake-and-mother-to-infant-pesticide-transfer-measured-by-deuterium-oxide-dilution-in-agricultural-and-urban-areas-of-mexico
#17
Ana Teresa Limon-Miro, Maria Lourdes Aldana-Madrid, Gerardo Alvarez-Hernandez, Lesley Evelyn Antunez-Roman, Guillermo Rodriguez-Olibarria, Mauro E Valencia Juillerat
Vector-borne diseases have increased pesticide use in urban areas (UA) and agricultural areas (AA) in Mexico. Breast milk can be contaminated by pesticide exposure. The objective of the study was to measure breast milk intake by deuterium oxide dilution as well as organochlorine and pyrethroid transfer from mother to infant in AA and UA of Sonora, Mexico. Human milk intake was determined by the 'dose-to-mother' technique using deuterium oxide (D2O) dilution. Mothers' body composition was also assessed by this technique and the intercept method...
April 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28475976/the-association-of-environmental-toxicants-and-autism-spectrum-disorders-in-children
#18
REVIEW
Bi Su Ye, Anna Oi Wah Leung, Ming Hung Wong
Autism spectrum disorders (ASDs) is a set of complex neurodevelopment disorders that is prevalent in children and is increasing at a steady rate in recent years. However, the etiology of autism is still poorly understood. Humans are at higher risk of chemical exposure than in the past as a result of the increasing usage of chemicals in various fields, including food preservation, agriculture, industrial production, etc. A number of environmental agents have been suggested as contributing factors to ASD pathogenesis, which includes heavy metals (Hg and Pb), persistent organic pollutants (DDT, PBDEs and PCBs) and emerging chemicals of concern (phthalates and BPA)...
May 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28474816/the-rise-of-glyphosate-and-new-opportunities-for-biosentinel-early-warning-studies
#19
Zoe Kissane, Jill M Shephard
Glyphosate has become the most commonly used herbicide worldwide, with a reputation of being environmentally benign, non-toxic and safe to wildlife and humans. However, studies have indicated its toxicity has been underestimated, and that its persistence in the environment is greater than once thought. Its actions as a neurotoxin and endocrine disruptor indicate its potential to act in similar ways to persistent organic pollutants (POPs) such as the organochlorine (OC) chemicals dichlorodiphenyltrichloroethane (DDT) and dioxin...
May 5, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28471346/involvement-of-oxidative-stress-in-the-mechanism-of-p-p-ddt-induced-nephrotoxicity-in-adult-rats
#20
Neila Marouani, Dorsaf Hallegue, Mohsen Sakly, Moncef Benkhalifa, Khémais Ben Rhouma, Olfa Tebourbi
The 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (p,p'-DDT) is an organochlorine pesticide that persists in the environment and has a risk to human health. We investigated whether p,p'-DDT-induces nephrotoxicity in rats and whether oxidative stress and apoptosis are involved in the pathogenesis of this process. Male rats received the pesticide at doses of 50 and 100 mg/kg for 10 days. Renal damage was evaluated by histopathological examination and serum markers. The oxidative stress was evaluated by lipid peroxidation (LPO), metallothioneins (MTs) and protein carbonyl levels...
May 4, 2017: General Physiology and Biophysics
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