Youhua Zhang, Feifei Song, Muqing Yang, Chunqiu Chen, Jiaqu Cui, Mengyu Xing, Yuna Dai, Man Li, Yuan Cao, Ling Lu, Huiyuan Zhu, Ying Liu, Chunlian Ma, Qing Wei, Huanlong Qin, Jiyu Li
Disrupted gastrointestinal (GI) motility is highly prevalent in patients with inflammatory bowel disease (IBD), but its potential causative role remains unknown. Herein, the role and the mechanism of impaired GI motility in colitis pathogenesis are investigated. Increased colonic mucosal inflammation is found in patients with chronic constipation (CC). Mice with GI dysmotility induced by genetic mutation or chemical insult exhibit increased susceptibility to colitis, dependent on the gut microbiota. GI dysmotility markedly decreases the abundance of Lactobacillus animlalis and increases the abundance of Akkermansia muciniphila...
March 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)