keyword
https://read.qxmd.com/read/38482625/specific-targeting-of-zinc-transporter-liv-1-with-immunocytokine-containing-anti-liv-1-vhh-and-human-il-2-and-evaluation-of-its-in-vitro-antitumor-activity
#21
JOURNAL ARTICLE
Rada Dehghan, Arezoo Beig Parikhani, Reza Ahangari Cohan, Mohammad Ali Shokrgozar, Esmat Mirabzadeh, Soheila Ajdary, Sirous Zeinali, Hajarossadat Ghaderi, Yeganeh Talebkhan, Mahdi Behdani
BACKGROUND: Interleukin 2 (IL-2) is a vital cytokine in the induction of T and NK cell responses, the proliferation of CD8+ T cells, and the effective treatment of human cancers, such as melanoma and renal cell carcinoma. However, widespread use of this cytokine is limited due to its short half-life, severe toxicity, lack of specific tumor targeting, and activation of Treg cells mediated by high-affinity interleukin-2 receptors. OBJECTIVE: In this study, a tumor-targeting LIV-1 VHH-mutIL2 immunocytokine with reduced CD25 (α chain of the high-affinity IL-2 receptor) binding activity was developed to improve IL-2 half-life by decreasing its renal infiltration in comparison with wild and mutant IL-2 molecules...
March 12, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38482416/construction-and-validation-of-a-joint-diagnosis-model-based-on-random-forest-and-artificial-intelligence-network-for-hepatitis-b-related-hepatocellular-carcinoma
#22
JOURNAL ARTICLE
Xili Jiang, Jiyun Hu, Shucai Xie
BACKGROUND: Hepatitis B virus (HBV) is the dominant pathogenic factor of hepatocellular carcinoma (HCC) in Asia and Africa. Early identification and clinical diagnosis are crucial for HBV-related HCC. Random forest (RF) and artificial neural network (ANN) were an innovative and highly effective supervised machine learning (ML) algorithm for the early diagnosis and screening of HBV-related HCC. This study aims to identify significant biomarkers and develop a novel genetic model for the efficient diagnosis of HBV-related HCC...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38482015/editorial-innovative-approaches-to-immune-tolerance-and-regulation-with-gene-cellular-protein-and-microbiome-based-therapeutics
#23
EDITORIAL
Amy Rosenberg, Dawn Elaine Smilek
No abstract text is available yet for this article.
2024: Frontiers in Immunology
https://read.qxmd.com/read/38481999/systemic-and-local-immunosuppression-in-glioblastoma-and-its-prognostic-significance
#24
REVIEW
Aleksei A Stepanenko, Anastasiia O Sosnovtseva, Marat P Valikhov, Anastasia A Chernysheva, Olga V Abramova, Konstantin A Pavlov, Vladimir P Chekhonin
The effectiveness of tumor therapy, especially immunotherapy and oncolytic virotherapy, critically depends on the activity of the host immune cells. However, various local and systemic mechanisms of immunosuppression operate in cancer patients. Tumor-associated immunosuppression involves deregulation of many components of immunity, including a decrease in the number of T lymphocytes (lymphopenia), an increase in the levels or ratios of circulating and tumor-infiltrating immunosuppressive subsets [e.g., macrophages, microglia, myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs)], as well as defective functions of subsets of antigen-presenting, helper and effector immune cell due to altered expression of various soluble and membrane proteins (receptors, costimulatory molecules, and cytokines)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38480676/refining-molecular-subtypes-and-risk-stratification-of-ovarian-cancer-through-multi-omics-consensus-portfolio-and-machine-learning
#25
JOURNAL ARTICLE
Jing Zhang, Shanshan He, Hongjun Ying
Ovarian cancer (OC), known for its pronounced heterogeneity, has long evaded a unified classification system despite extensive research efforts. This study integrated five distinct multi-omics datasets from eight multicentric cohorts, applying a combination of ten clustering algorithms and ninety-nine machine learning models. This methodology has enabled us to refine the molecular subtyping of OC, leading to the development of a novel Consensus Machine Learning-driven Signature (CMLS). Our analysis delineated two prognostically significant cancer subtypes (CS), each marked by unique genetic and immunological signatures...
March 13, 2024: Environmental Toxicology
https://read.qxmd.com/read/38479724/rho-kinase-inhibitor-alleviates-cd4-t-cell-mediated-corneal-graft-rejection-by-modulating-its-stat3-and-stat5-activation
#26
JOURNAL ARTICLE
Shang Li, Peng Zhang, Ao Li, Jiayu Bao, Zhiqiang Pan, Ying Jie
Penetrating keratoplasty remains the most common treatment to restore vision for corneal diseases. Immune rejection after corneal transplantation is one of the major causes of graft failure. In recent years, Rho-associated protein kinase (ROCK) inhibitors have been found to be associated with the activation of the STATs pathway and are widely studied in autoimmune diseases. Therefore, it may be possible that the ROCK inhibitors also participate in the local and systemic immune regulation in corneal transplantation through activation of the STATs pathway and affect the CD4+ T cell differentiation...
March 11, 2024: Experimental Eye Research
https://read.qxmd.com/read/38479351/engineering-antigen-specific-tolerance-to-an-artificial-protein-hydrogel
#27
JOURNAL ARTICLE
Peter B Rapp, Joshua A Baccile, Rachel P Galimidi, Jost Vielmetter
Artificial protein hydrogels are an emerging class of biomaterials with numerous prospective applications in tissue engineering and regenerative medicine. These materials are likely to be immunogenic due to their frequent incorporation of novel amino acid sequence domains, which often serve a functional role within the material itself. We engineered injectable "self" and "nonself" artificial protein hydrogels, which were predicted to have divergent immune outcomes in vivo on the basis of their primary amino acid sequence...
March 13, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38478709/pgam1-suppression-remodels-the-tumor-microenvironment-in-triple-negative-breast-cancer-and-synergizes-with-anti-pd-1-immunotherapy
#28
JOURNAL ARTICLE
Dong Zhang, Min Wang, Wenying Wang, Shiya Ma, Wenwen Yu, Xiubao Ren, Qian Sun
Triple-negative breast cancer (TNBC) is a high-risk form of breast cancer with a high metastatic potential and lack of effective therapies. Immunotherapy has shown encouraging clinical benefits, and its efficacy in TNBC is affected by immunocyte infiltration in the tumor microenvironment (TME). Phosphoglycerate mutase 1 (PGAM1) is a key enzyme involved in cancer metabolism; however, its role in the TME remains unclear. In this study, we aimed to investigate the role of PGAM1 in TNBC and determine the potential of PGAM1 inhibition in combination with anti-PD-1 immunotherapy...
March 13, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38478632/harnessing-regulatory-t-cells-to-establish-immune-tolerance
#29
REVIEW
Patrick Ho, Ellen Cahir-McFarland, Jason D Fontenot, Tracey Lodie, Adel Nada, Qizhi Tang, Laurence A Turka, Jeffrey A Bluestone
Engineered regulatory T (Treg ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered Treg cell therapies in treating autoimmune and other inflammatory diseases.
March 13, 2024: Science Translational Medicine
https://read.qxmd.com/read/38478104/predominance-of-t-bet-positive-th1-cells-in-infiltrating-t-lymphocytes-in-most-of-active-arteritis-lesions-of-giant-cell-arteritis
#30
JOURNAL ARTICLE
Hidetoshi Satomi, Mikiko Kobayashi, Ichiro Ito, Koji Asano, Mutsuki Makino, Kenji Kawaguchi, Hiroyuki Kanno
Immunological mechanisms through the activation of CD4-positive T-cells have been assumed to be involved in the pathogenesis of giant cell arteritis (GCA). Many studies employing frozen tissues of temporal artery biopsy, peripheral blood lymphocytes, and plasma of GCA patients have revealed the contribution of interferon-γ and interleukin-17 in both protein and mRNA levels. However, the analyses using formalin-fixed and paraffin-embedded (FFPE) tissue specimens, in which the correlation between histopathologic pictures and immunological circumstances would be elucidated, have been limited...
March 13, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38477949/regulatory-effects-of-long-non-coding-rnas-on-th17-treg-differentiation-and-imbalance
#31
JOURNAL ARTICLE
Reza Dabbaghipour, Elham Ahmadi, Mona Entezam, Omid Rahbar Farzam, Amir Baghbanzadeh, Ali Saber Sichani, Nazila Jalilzadeh, Mahdi Jafarlou, Behzad Baradaran
Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio...
December 28, 2023: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38477663/berberine-a-natural-modulator-of-immune-cells-in-multiple-sclerosis
#32
REVIEW
Esmaeil Yazdanpanah, Sepehr Dadfar, Alireza Shadab, Niloufar Orooji, MohammadHossein Nemati, Alireza Pazoki, Seyed-Alireza Esmaeili, Rasoul Baharlou, Dariush Haghmorad
Berberine is a benzylisoquinoline alkaloid found in such plants as Berberis vulgaris, Berberis aristata, and others, revealing a variety of pharmacological properties as a result of interacting with different cellular and molecular targets. Recent studies have shown the immunomodulatory effects of Berberine which result from its impacts on immune cells and immune response mediators such as diverse T lymphocyte subsets, dendritic cells (DCs), and different inflammatory cytokines. Multiple sclerosis (MS) is a chronic disabling and neurodegenerative disease of the central nervous system (CNS) characterized by the recruitment of autoreactive T cells into the CNS causing demyelination, axonal damage, and oligodendrocyte loss...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38477534/gastrointestinal-dysmotility-predisposes-to-colitis-through-regulation-of-gut-microbial-composition-and-linoleic-acid-metabolism
#33
JOURNAL ARTICLE
Youhua Zhang, Feifei Song, Muqing Yang, Chunqiu Chen, Jiaqu Cui, Mengyu Xing, Yuna Dai, Man Li, Yuan Cao, Ling Lu, Huiyuan Zhu, Ying Liu, Chunlian Ma, Qing Wei, Huanlong Qin, Jiyu Li
Disrupted gastrointestinal (GI) motility is highly prevalent in patients with inflammatory bowel disease (IBD), but its potential causative role remains unknown. Herein, the role and the mechanism of impaired GI motility in colitis pathogenesis are investigated. Increased colonic mucosal inflammation is found in patients with chronic constipation (CC). Mice with GI dysmotility induced by genetic mutation or chemical insult exhibit increased susceptibility to colitis, dependent on the gut microbiota. GI dysmotility markedly decreases the abundance of Lactobacillus animlalis and increases the abundance of Akkermansia muciniphila...
March 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38476610/prognostic-biomarker-cpeb3-and-its-associations-with-immune-infiltration-in-clear-cell-renal-cell-carcinoma
#34
JOURNAL ARTICLE
Hualan Hong, Xi Shi, Wenyong Ou, Pengju Ou
The role and underlying mechanism of cytoplasmic polyadenylation element binding protein 3 (CPEB3) in clear cell renal cell carcinoma [ccRCC progression remain poorly characterized. The present study was designed to evaluate the role of CPEB3 in ccRCC and its clinical associations. The overall response rate of first-line therapies (ICIs combined with VEGFR-TKIs or ICI combination) for ccRCC] is 42.0-59.3%, so a number of patients with ccRCC do not benefit from these therapies. To avoid immunosurveillance and immune killing, tumor cells decrease immunogenicity and recruit immunosuppressive cells such as regulatory T cells (Tregs)...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38474590/adjuvant-novel-nanocarrier-based-targeted-therapy-for-lung-cancer
#35
REVIEW
Kangkan Sarma, Md Habban Akther, Irfan Ahmad, Obaid Afzal, Abdulmalik S A Altamimi, Manal A Alossaimi, Mariusz Jaremko, Abdul-Hamid Emwas, Preety Gautam
Lung cancer has the lowest survival rate due to its late-stage diagnosis, poor prognosis, and intra-tumoral heterogeneity. These factors decrease the effectiveness of treatment. They release chemokines and cytokines from the tumor microenvironment (TME). To improve the effectiveness of treatment, researchers emphasize personalized adjuvant therapies along with conventional ones. Targeted chemotherapeutic drug delivery systems and specific pathway-blocking agents using nanocarriers are a few of them. This study explored the nanocarrier roles and strategies to improve the treatment profile's effectiveness by striving for TME...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38474403/advances-and-challenges-in-sepsis-management-modern-tools-and-future-directions
#36
REVIEW
Elena Santacroce, Miriam D'Angerio, Alin Liviu Ciobanu, Linda Masini, Domenico Lo Tartaro, Irene Coloretti, Stefano Busani, Ignacio Rubio, Marianna Meschiari, Erica Franceschini, Cristina Mussini, Massimo Girardis, Lara Gibellini, Andrea Cossarizza, Sara De Biasi
Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare regulatory T cells (Tregs) but significantly affects other lymphocyte subsets, leading to diminished effector functions, altered cytokine profiles, and metabolic changes. The complexity of sepsis stems not only from its pathophysiology but also from the heterogeneity of patient responses, posing significant challenges in developing universally effective therapies...
March 2, 2024: Cells
https://read.qxmd.com/read/38474381/gene-signature-of-regulatory-t-cells-isolated-from-children-with-selective-iga-deficiency-and-common-variable-immunodeficiency
#37
JOURNAL ARTICLE
Magdalena Rutkowska-ZapaƂa, Agnieszka Grabowska-Gurgul, Marzena Lenart, Anna Szaflarska, Anna Kluczewska, Monika Mach-Tomalska, Monika Baj-Krzyworzeka, Maciej Siedlar
Selective IgA deficiency (SIgAD) is the most common form and common variable immunodeficiency (CVID) is the most symptomatic form of predominant antibody deficiency. Despite differences in the clinical picture, a similar genetic background is suggested. A common feature of both disorders is the occurrence of autoimmune conditions. Regulatory T cells (Tregs ) are the major immune cell type that maintains autoimmune tolerance. As the different types of abnormalities of Treg cells have been associated with autoimmune disorders in primary immunodeficiency (PID) patients, in our study we aimed to analyze the gene expression profiles of Treg cells in CVID and SIgAD patients compared to age-matched healthy controls...
February 27, 2024: Cells
https://read.qxmd.com/read/38474199/a-comparison-of-spatial-and-phenotypic-immune-profiles-of-pancreatic-ductal-adenocarcinoma-and-its-precursor-lesions
#38
JOURNAL ARTICLE
Thomas Enzler, Jiaqi Shi, Jake McGue, Brian D Griffith, Lei Sun, Vaibhav Sahai, Hari Nathan, Timothy L Frankel
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of 12.5%. PDAC predominantly arises from non-cystic pancreatic intraepithelial neoplasia (PanIN) and cystic intraductal papillary mucinous neoplasm (IPMN). We used multiplex immunofluorescence and computational imaging technology to characterize, map, and compare the immune microenvironments (IMEs) of PDAC and its precursor lesions. We demonstrate that the IME of IPMN was abundantly infiltrated with CD8+ T cells and PD-L1-positive antigen-presenting cells (APCs), whereas the IME of PanIN contained fewer CD8+ T cells and fewer PD-L1-positive APCs but elevated numbers of immunosuppressive regulatory T cells (Tregs)...
March 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474140/single-cell-high-dimensional-analysis-of-human-peripheral-blood-mononuclear-cells-reveals-unique-intermediate-monocyte-subsets-associated-with-sex-differences-in-coronary-artery-disease
#39
JOURNAL ARTICLE
Nandini Chatterjee, Ravi K Komaravolu, Christopher P Durant, Runpei Wu, Chantel McSkimming, Fabrizio Drago, Sunil Kumar, Gabriel Valentin-Guillama, Yury I Miller, Coleen A McNamara, Klaus Ley, Angela Taylor, Ahmad Alimadadi, Catherine C Hedrick
Monocytes are associated with human cardiovascular disease progression. Monocytes are segregated into three major subsets: classical (cMo), intermediate (iMo), and nonclassical (nMo). Recent studies have identified heterogeneity within each of these main monocyte classes, yet the extent to which these subsets contribute to heart disease progression is not known. Peripheral blood mononuclear cells (PBMC) were obtained from 61 human subjects within the Coronary Assessment of Virginia (CAVA) Cohort. Coronary atherosclerosis severity was quantified using the Gensini Score (GS)...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474078/carbon-ion-irradiation-activates-anti-cancer-immunity
#40
REVIEW
Makoto Sudo, Hiroko Tsutsui, Jiro Fujimoto
Carbon ion beams have the unique property of higher linear energy transfer, which causes clustered damage of DNA, impacting the cell repair system. This sometimes triggers apoptosis and the release in the cytoplasm of damaged DNA, leading to type I interferon (IFN) secretion via the activation of the cyclic GMP-AMP synthase-stimulator of interferon genes pathway. Dendritic cells phagocytize dead cancer cells and damaged DNA derived from injured cancer cells, which together activate dendritic cells to present cancer-derived antigens to antigen-specific T cells in the lymph nodes...
February 29, 2024: International Journal of Molecular Sciences
keyword
keyword
3754
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.