keyword
https://read.qxmd.com/read/38495876/leukemic-mutation-flt3-itd-is-retained-in-dendritic-cells-and-disrupts-their-homeostasis-leading-to-expanded-th17-frequency
#1
JOURNAL ARTICLE
Patrick A Flynn, Mark D Long, Yoko Kosaka, Nicola Long, Jessica S Mulkey, Jesse L Coy, Anupriya Agarwal, Evan F Lind
Dendritic cells (DC) are mediators between innate and adaptive immune responses to pathogens and tumors. DC development is determined by signaling through the receptor tyrosine kinase Fms-like tyrosine kinase 3 (FLT3) in bone marrow myeloid progenitors. Recently the naming conventions for DC phenotypes have been updated to distinguish between "Conventional" DCs (cDCs) and plasmacytoid DCs (pDCs). Activating mutations of FLT3, including Internal Tandem Duplication (FLT3-ITD), are associated with poor prognosis for acute myeloid leukemia (AML) patients...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38494386/suppressor-t-helper-type-17-cell-responses-in-intestinal-transplant-recipients-with-allograft-rejection
#2
JOURNAL ARTICLE
Leonid Belyayev, Jiman Kang, Mohammed Sadat, Katrina Loh, Digvijay Patil, Vinona Muralidaran, Khalid Khan, Stuart Kaufman, Sukanya Subramanian, Yuriy Gusev, Krithika Bhuvaneshwar, Habtom Ressom, Rency Varghese, Udeme Ekong, Cal S Matsumoto, Simon C Robson, Thomas M Fishbein, Alexander Kroemer
BACKGROUND: Intestinal transplant (ITx) rejection is associated with memory T helper type 17 cell (Th17) infiltration of grafted tissues. Modulation of Th17 effector cell response is facilitated by T regulatory (Treg) cells, but a phenotypic characterization of this process is lacking in the context of allograft rejection. METHODS: Flow cytometry was performed to examine the expression of surface receptors, cytokines, and transcription factors in Th17 and Treg cells in ITx control (n = 34) and rejection patients (n = 23)...
March 16, 2024: Human Immunology
https://read.qxmd.com/read/38494360/immunocyte-profiling-changes-in-patients-received-epidural-versus-intravenous-analgesia-after-pancreatectomy-a-randomized-controlled-trial
#3
JOURNAL ARTICLE
Chun-Yu Wu, Ting-Chun Kuo, Han-Wei Lin, Jen-Ting Yang, Wen-Hsiu Chen, Wen-Fang Cheng, Yu-Wen Tien, Kuang-Cheng Chan
BACKGROUND: Perioperative immunosuppressants, such as surgical stress and opioid use may downregulate anti-cancer immunocytes for patients undergoing pancreatectomy. Thoracic epidural analgesia (TEA) may attenuate these negative effects and provide better anti-cancer immunocyte profile change than intravenous analgesia using opioid. METHODS: We randomly assigned 108 adult patients undergoing pancreatectomy to receive one of two 72-h postoperative analgesia protocols: one was TEA, and the other was intravenous patient-controlled analgesia (IV-PCA)...
March 16, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38492746/migratory-cd103-cd11b-cdc2-cells-in-peyer-s-patches-are-critical-for-gut-iga-responses-following-oral-immunization
#4
JOURNAL ARTICLE
Inta Gribonika, Anneli Strömberg, Rakesh K Chandode, Karin Schön, Katharina Lahl, Mats Bemark, Nils Lycke
Induction and regulation of specific intestinal IgA responses critically depend on dendritic cell subsets and the T cells they activate in the Peyer's patches (PP). We found that oral immunization with cholera toxin (CT) as an adjuvant resulted in migration-dependent changes in the composition and localization of PP DC subsets with increased numbers of CD103- cDC2s and LysoDCs in the subepithelial dome and of CD103+ cDC2s that expressed CD101 in the T cell zones (TZ), while oral OVA tolerization was instead associated with larger quantities of TZ cDC1s and pTregs...
March 14, 2024: Mucosal Immunology
https://read.qxmd.com/read/38492341/hif-1%C3%AE-induced-by-hypoxic-condition-regulates-treg-th17-axis-polarization-in-chronic-immune-thrombocytopenia
#5
JOURNAL ARTICLE
Hao Gu, Zhifa Wang, Xingjuan Xie, Hui Chen, Juntao Ouyang, Runhui Wu, Zhenping Chen
Immune thrombocytopenia (ITP) is an acquired immune disorder characterized by increased platelet destruction and reduced platelet (Plt) production. Hypoxia-inducible factor-1α (HIF-1α) have regulatory effects on Treg/Th17 axis balance and may represent relevant factors in the pathogenesis of ITP. Treg/Th17 ratio, serum levels and gene expression were investigated in new diagnosed ITP (NITP) and chronic ITP (CITP). The Treg/Th17 ratio obviously decreased in CITP (P = 0.001). The ratio of Treg/Th17 was correlated with the level of HIF-1α level both in mRNA (r = 0...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38492221/tonic-tcr-and-il-1%C3%AE-signaling-mediate-phenotypic-alterations-of-naive-cd4-t%C3%A2-cells
#6
JOURNAL ARTICLE
Takashi Sekiya, Shinya Hidano, Satoshi Takaki
Inert naive CD4+ T (TN ) cells differentiate into functional T helper (Th) or regulatory T (Treg) cell subsets upon encountering antigens, mediating properly directed immune responses. Although all TN cells can differentiate into any of the Th and Treg cell subsets, heterogeneity exists among TN cells. By constructing reporter mice to detect ongoing T cell receptor (TCR) signaling, we identify that interleukin (IL)-1β signaling affects TN cell characteristics, independent of tonic TCR signaling, which also alters TN cell phenotypes...
March 15, 2024: Cell Reports
https://read.qxmd.com/read/38491831/decreased-interleukin-17ra-expression-is-associated-with-good-prognosis-in-patients-with-colorectal-cancer-and-inhibits-tumor-growth-and-vascularity-in-mice
#7
JOURNAL ARTICLE
Jeng-Kai Jiang, Chi-Hung Lin, Ting-An Chang, Liang-Chuan Lo, Chien-Ping Lin, Ruey-Hwa Lu, Chih-Yung Yang
BACKGROUND: Interleukin-17 (IL-17) is a pro-inflammatory cytokine that plays a vital role in the promotion of tumorigenesis in various cancers, including colorectal cancer (CRC). Based on current evidence, IL-17 binds to interleukin-17 receptor A (IL-17RA); however, the role of IL-17RA has not been elucidated in previous studies on CRC. In this study, we explored the role of IL-17RA in human CRC tissues and the progression of CRC in humans and mice. METHODS: The expressions of IL-17RA and epithelial-mesenchymal transition (EMT)-related genes were examined in CRC cells and tissue samples by quantitative real-time polymerase chain reaction...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491484/irf4-mediated-treg-phenotype-switching-can-aggravate-hyperoxia-induced-alveolar-epithelial-cell-injury
#8
JOURNAL ARTICLE
He Langyue, Zhu Ying, Jiang Jianfeng, Zhu Yue, Yao Huici, Lu Hongyan
Bronchopulmonary dysplasia (BPD) is characterized by alveolar dysplasia, and evidence indicates that interferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various inflammatory lung diseases. Nonetheless, the significance and mechanism of IRF4 in BPD remain unelucidated. Consequently, we established a mouse model of BPD through hyperoxia exposure, and ELISA was employed to measure interleukin-17 A (IL-17 A) and interleukin-6 (IL-6) expression levels in lung tissues. Western blotting was adopted to determine the expression of IRF4, surfactant protein C (SP-C), and podoplanin (T1α) in lung tissues...
March 15, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38491354/association-of-lymphocyte-subsets-with-the-efficacy-and-prognosis-of-pd%C3%A2-1-inhibitor-therapy-in-advanced-gastric-cancer-results-from-a-monocentric-retrospective-study
#9
JOURNAL ARTICLE
Xinyan Wang, Xiaoling Liu, Huwei Dai, Junmei Jia
PURPOSE: This retrospective study aimed to investigate the changes in peripheral blood lymphocyte subsets before and after immunotherapy in patients with advanced gastric cancer and their relationship n with the therapeutic efficacy and clinical prognosis. METHODS: Peripheral blood lymphocyte subsets, including CD4 + T cells, CD8 + T cells, CD4+/CD8 + ratio, NK cells, Treg cells, and B cells, were collected from 195 patients with advanced gastric cancer who were admitted to the First Hospital of Shanxi Medical University with immunotherapy from January 2020 to October 2021, at the time of diagnosis of advanced gastric cancer, before immunotherapy and after 3 cycles of immunotherapy...
March 15, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38491291/characterizing-the-immune-response-to-myocardial-infarction-in-pigs
#10
JOURNAL ARTICLE
Florian Schnitter, Franziska Stangl, Elisabeth Noeske, Maya Bille, Anja Stadtmüller, Niklas Vogt, Florian Sicklinger, Florian Leuschner, Anna Frey, Laura Schreiber, Stefan Frantz, Niklas Beyersdorf, Gustavo Ramos, Nadine Gladow, Ulrich Hofmann
Though myocardial infarction (MI) in pigs is a well-established translational large animal model, it has not yet been widely used for immunotherapy studies, and a comprehensive description of the immune response to MI in this species is lacking. We induced MI in Landrace pigs by balloon occlusion of the left anterior descending artery over 90 min. Within 14 days, the necrotic myocardium was progressively replaced by scar tissue with involvement of myofibroblasts. We characterized the immune response in the heart ex vivo by (immuno)histology, flow cytometry, and RNA sequencing of myocardial tissue on days 3, 7, and 14 after MI...
March 15, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38491211/a-distinct-repair-role-of-regulatory-t-cells-in-fracture-healing
#11
JOURNAL ARTICLE
Tingting Wu, Lulu Wang, Chen Jian, Zhenhe Zhang, Ruiyin Zeng, Bobin Mi, Guohui Liu, Yu Zhang, Chen Shi
Regulatory T cells (Tregs) suppress immune responses and inflammation. Here, we described the distinct nonimmunological role of Tregs in fracture healing. The recruitment from the circulation pool, peripheral induction, and local expansion rapidly enriched Tregs in the injured bone. The Tregs in the injured bone displayed superiority in direct osteogenesis over Tregs from lymphoid organs. Punctual depletion of Tregs compromised the fracture healing process, which leads to increased bone nonunion. In addition, bone callus Tregs showed unique T-cell receptor repertoires...
March 16, 2024: Frontiers of Medicine
https://read.qxmd.com/read/38491084/cd4-cd25-regulatory-t-cells-ex-vivo-generated-from-autologous-na%C3%A3-ve-cd4-t-cells-suppress-eae-progression
#12
JOURNAL ARTICLE
Ting-Ting Yang, Pen-Ju Liu, Qing-Yu Sun, Ze-Yi Wang, Guo-Bin Yuan, Ze-Xin Fan, Lin Ma, Jian-Feng Lu, Bo-Yi Yuan, Wen-Long Zou, Li-Min Zhao, Qian Li, Guang-Zhi Liu
CD4+ CD25+ regulatory T cells (Tregs) play an important role in maintaining immune homeostasis in multiple sclerosis (MS). Hence, we aimed to explore the therapeutic efficacy and safety of adoptive cell therapy (ACT) utilizing induced antigen-specific Tregs in an animal model of MS, that is, in an experimental autoimmune encephalomyelitis (EAE) model. B cells from EAE model that were activated with soluble CD40L were used as antigen-presenting cells (APCs) to induce the differentiation of antigen-specific Tregs from naïve CD4 precursors, and then, a stepwise isolation of CD4+ CD25high CD127low Tregs was performed using a flow sorter...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490295/long-term-follow-up-of-abatacept-post-transplantation-cyclophosphamide-and-sirolimus-abacys-based-haploidentical-transplantation-in-younger-patients-with-nonmalignant-diseases
#13
JOURNAL ARTICLE
Sarita Rani Jaiswal, Mahak Agarwal, Gitali Bhagawati, Bhudev Chandra Das, Prakash Baligar, Manoj Garg, Subhrajit Biswas, Suparno Chakrabarti
BACKGROUND: Haploidentical (Haplo) HCT for nonmalignant diseases (NMD) faces inherent challenges of both alloreactivity and graft failure. Building upon promising results from pilot studies, where abatacept was combined with post-transplantation cyclophosphamide (PTCy) and sirolimus (AbaCyS) in younger NMD patients undergoing haplo-HCT, we present the long-term outcomes of this protocol. STUDY DESIGN: On the back of uniform disease-specific conditioning regimens containing ATG (4...
March 13, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38489115/modulation-of-t-cell-differentiation-in-mice-with-copd-combined-with-lung-cancer-through-key-targets-of-pd-1-by-tao-hong-si-wu-tang
#14
JOURNAL ARTICLE
Guoli Wang, Ge Wang, Keming Zhao, Aifeng Sui, Lina Wang, Yanling Xu, Nini Qu, Xiande Ma, Hu Deng
The objective is to assess the anti-inflammatory effect of Tao Hong Si Wu Tang combined with anti-PD-1 in a mouse model of COPD combined with lung cancer, elucidating its mechanism through modulation of PD-1/PD-L binding, regulation of Th1/Th2 and Th17/Treg balance, inhibition of IL-4 and IL-17, and promotion of IFN-γ and TGF-β levels in peripheral blood. One hundred male C57/BL6 mice were randomly allocated to five groups: A (blank control), B (model control), C (THSW), D (anti-PD-1), and E (THSW + anti-PD-1), with 20 mice in each group...
March 15, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38488697/undaria-pinnatifida-ameliorates-nasal-inflammation-by-inhibiting-eosinophil-and-mast-cell-activation-and-modulating-the-nf-%C3%AE%C2%BAb-mapks-signaling-pathway
#15
JOURNAL ARTICLE
Zhen Nan Yu, Yan Jing Fan, Thi Van Nguyen, Chun Hua Piao, Byung-Hoo Lee, So-Young Lee, Hee Soon Shin, Chang Ho Song, Ok Hee Chai
BACKGROUND: Allergic rhinitis (AR) is the most prevalent form of atopic disease. Undaria pinnatifida has potent antioxidative, antidiabetic, and anti-inflammatory properties. AIMS: We investigated the immunomodulatory effect of Undaria pinnatifida extract (UPE) on allergic inflammation in an AR mouse model. MATERIALS & METHODS: Mice were sensitized and intranasally challenged with ovalbumin (OVA), and the Th1/Th2 and Th17/Treg-related cytokines and histopathology were exanimated after UPE treatments...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38486772/insufficient-phosphorylation-of-stat5-in-tregs-inhibits-the-expression-of-blimp-1-but-not-irf4-reduction-the-proportion-of-tregs-in-pediatric-aplastic-anemia
#16
JOURNAL ARTICLE
Lifen Huang, Junbin Huang, Nannan Tang, Hongman Xue, Shaofen Lin, Su Liu, Qihui Chen, Yinsi Lu, Qian Liang, Yun Wang, Qingqing Zhu, Guoxing Zheng, Yun Chen, Chengming Zhu, Chun Chen
Deficiency in regulatory T cells (Tregs) is an important mechanism underlying the pathogenesis of pediatric aplastic anemia, but its specific mechanism is unclear. In our study, we aimed to investigate whether IL-2/STAT5 can regulate the proliferation of Tregs in aplastic anemia (AA) by regulating their expression of B lymphocyte-induced mature protein-1 (BLIMP-1) or interferon regulatory factor 4 (IRF4). Through clinical research and animal experiments, we found that poor activation of the IL-2/STAT5 signaling pathway may leads to low expression of BLIMP-1 in Tregs of children with AA, which leads to defects in the differentiation and proliferation of Tregs in AA...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38486310/preclinical-and-translational-pharmacology-of-afucosylated-anti-ccr8-antibody-for-depletion-of-tumour-infiltrating-regulatory-t-cells
#17
JOURNAL ARTICLE
Gautham Gampa, Phillip Spinosa, Jennifer Getz, Yu Zhong, Wendy Halpern, Emel Esen, John Davies, Cassie Chou, Mandy Kwong, Yingyun Wang, Teresita L Arenzana, Vittal Shivva, Mahrukh Huseni, Robert Hsieh, Jill Schartner, James T Koerber, Sascha Rutz, Iraj Hosseini
BACKGROUND AND PURPOSE: RO7502175 is an afucosylated antibody designed to eliminate C-C motif chemokine receptor 8 (CCR8)+ Treg cells in the tumour microenvironment through enhanced antibody-dependent cellular cytotoxicity (ADCC). EXPERIMENTAL APPROACH: We report findings from preclinical studies characterizing pharmacology, pharmacokinetics (PK)/pharmacodynamics (PD) and safety profile of RO7502175 and discuss the translational PK/PD approach used to inform first-in-human (FiH) dosing strategy and clinical development in solid tumour indications...
March 14, 2024: British Journal of Pharmacology
https://read.qxmd.com/read/38486224/exosomal-mirnas-expression-and-growth-factors-released-by-mononuclear-cells-of-clad-patients-in-response-to-extracorporeal-photopheresis
#18
JOURNAL ARTICLE
Sara Bozzini, Eleonora Bozza, Cecilia Bagnera, Claudia Del Fante, Eugenio Barone, Simona De Vitis, Mara De Amici, Giorgia Testa, Stefania Croce, Chiara Valsecchi, Maria A Avanzini, Rosalia Cacciatore, Cristina Mortellaro, Gianluca Viarengo, Cesare Perotti, Federica Meloni
BACKGROUND: CLAD (Chronic Lung Allograft Dysfunction) remains a serious complication following lung transplantation. Some evidence shows that portions of Extracorporeal Photopheresis (ECP)-treated patients improve/stabilize their graft function. In spite of that, data concerning molecular mechanisms are still lacking. Aims of our study were to assess whether ECP effects are mediated by Mononuclear Cells (MNCs) modulation in term of microRNAs (miRNAs) expression and growth factors release...
March 14, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38485905/unraveling-the-impact-of-blood-transfusion-on-transcription-factors-regulating-t-helper-1-2-17-and-regulatory-t-cells
#19
JOURNAL ARTICLE
Samad Valizadeh, Azita Chegini, Faranak Behnaz, Ali Akbar Pourfatollah, Shahram Samiee, Ronak Karbalaeifar
T helper 1 (TH1) and TH2 lymphocytes are the most important components of the immune system affected by blood transfusion. This study aimed`` to evaluate the effect of blood transfusion on gene expression of transcription factors related to the development of TH1, TH2, TH17 and regulatory T cells (Tregs). In this cross-sectional study, 20 patients diagnosed with abdominal aortic aneurysms requiring surgical repair were studied from January 2018 to August 2020. We utilized real-time PCR to evaluate the expression of transcription factor genes associated with TH1, TH2, TH17, and Treg, namely T-box-expressed-in-T-cells (T-bet), GATA-binding protein 3 (GATA-3), retinoid-related orphan receptor (RORγt), and fork head box protein 3 (Foxp3), respectively...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485600/dendritic-cells-and-antigen-specific-immunotherapy-in-autoimmune-rheumatic-diseases
#20
REVIEW
Benjamin Cai, Ranjeny Thomas
Dendritic cells (DCs) are professional antigen-presenting cells and trigger downstream immune responses to antigen while integrating cellular pathogen and damage-associated molecular pattern (PAMP and DAMP) or immunomodulatory signals. In healthy individuals, resting and tolerogenic DCs draining skin and intestine facilitate expansion of regulatory T cells (Treg) to maintain peripheral antigen-specific immune tolerance. In patients with rheumatic diseases, however, DCs activated by PAMPs and DAMPs expand self-reactive effector T cells, including follicular helper T cells that promote the expansion of activated autoreactive B cells, chronic inflammation and end-organ damage...
March 13, 2024: Best Practice & Research. Clinical Rheumatology
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