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https://www.readbyqxmd.com/read/28071968/rapid-and-robust-authentication-of-deer-antler-velvet-product-by-fast-pcr-rflp-analysis
#1
Chao Jiang, Yan Jin, Xinlei Zhao, Yuan Yuan, Yuyang Zhao, Luqi Huang
Deer antler velvet is widely used as a vitalizing, tonifying, haemopoietic and strengthening agent for debilitated persons in East Asia. To develop a rapid and sensitive method for the identification of the biological source or origin in antler velvet products, a molecular approach was applied using PCR-restriction fragment length polymorphism analysis. The cytochrome b gene sequences of nine cervidae species were analyzed, and a Dde I restriction endonuclease recognition site was found only in sika deer and red deer, the official origin of deer velvet in Chinese pharmacopoeia...
January 10, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28065657/mapping-the-binding-site-of-bms-708163-on-%C3%AE-secretase-with-cleavable-photoprobes
#2
Natalya Gertsik, Christopher W Am Ende, Kieran F Geoghegan, Chuong Nguyen, Paramita Mukherjee, Scot Mente, Uthpala Seneviratne, Douglas S Johnson, Yue-Ming Li
γ-Secretase, a four-subunit transmembrane aspartic proteinase, is a highly valued drug target in Alzheimer's disease and cancer. Despite significant progress in structural studies, the respective molecular mechanisms and binding modes of γ-secretase inhibitors (GSIs) and modulators (GSMs) remain uncertain. Here, we developed biotinylated cleavable-linker photoprobes based on the BMS-708163 GSI to study its interaction with γ-secretase. Comparison of four cleavable linkers indicated that the hydrazine-labile N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker was cleaved most efficiently to release photolabeled and affinity-captured presenilin-1 (PS1), the catalytic subunit of γ-secretase...
January 5, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28065571/exposure-to-ddt-and-diabetic-nephropathy-among-mexican-americans-in-the-1999-2004-national-health-and-nutrition-examination-survey
#3
Charles J Everett, Olivia M Thompson, Clara E Dismuke
Concentrations of the pesticide DDT (dichlorodiphenyltrichloroethane) and its metabolite DDE (dichlorodiphenyldichloroethylene), in the blood of Mexican Americans, were evaluated to determine their relationships with diabetes and diabetic nephropathy. The data were derived from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 (unweighted N = 1,411, population estimate = 13,760,609). The sample included teens, 12-19 years old, which accounted for 19.8% of the data. The time of the study overlapped the banning of DDT in Mexico in the year 2000, and those participants born in Mexico were exposed to DDT before they immigrated to the US...
January 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28063657/persistent-organic-pollutants-pops-in-the-atmosphere-of-three-chilean-cities-using-passive-air-samplers
#4
Karla Pozo, Germán Oyola, Victor H Estellano, Tom Harner, Anny Rudolph, Petra Prybilova, Petr Kukucka, Ondrej Audi, Jana Klánová, America Metzdorff, Silvano Focardi
In this study passive air samplers containing polyurethane foam (PUF) disks were deployed in three cities across Chile; Santiago (STG) (n=5, sampling sites), Concepciόn (CON) (n=6) and Temuco (TEM) (n=6) from 2008 to 2009. Polychlorinated biphenyls (PCBs) (7 indicator congeners), chlorinated pesticides hexachlorocyclohexanes (HCHs), dichlorodiphenyl trichloroethanes (DDTs) and flame retardants such as polybrominated diphenyl ethers (PBDEs) were determined by gas chromatography coupled mass spectrometry (GC/MS)...
January 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28047898/tu-h-campus-jep1-05-dose-deformation-error-associated-with-deformable-image-registration-pathways
#5
M Surucu, A Woerner, J Roeske
PURPOSE: To evaluate errors associated with using different deformable image registration (DIR) pathways to deform dose from planning CT (pCT) to cone-beam CT (CBCT). METHODS: Deforming dose is controversial because of the lack of quality assurance tools. We previously proposed a novel metric to evaluate dose deformation error (DDE) by warping dose information using two methods, via dose and contour deformation. First, isodose lines of the pCT were converted into structures and then deformed to the CBCT using an image based deformation map (dose/structure/deform)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047680/su-f-j-111-a-novel-distance-dose-weighting-method-for-label-fusion-in-multi-atlas-segmentation-for-prostate-radiation-therapy
#6
J Chang, X Gu, W Lu, T Song, S Jiang
PURPOSE: A novel distance-dose weighting method for label fusion was developed to increase segmentation accuracy in dosimetrically important regions for prostate radiation therapy. METHODS: Label fusion as implemented in the original SIMPLE (OS) for multi-atlas segmentation relies iteratively on the majority vote to generate an estimated ground truth and DICE similarity measure to screen candidates. The proposed distance-dose weighting puts more values on dosimetrically important regions when calculating similarity measure...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043072/association-of-serum-organochlorine-pesticides-concentrations-with-reproductive-hormone-levels-and-polycystic-ovary-syndrome-in-a-chinese-population
#7
Zhizhun Guo, Huiling Qiu, Lingling Wang, Lijun Wang, Chonggang Wang, Meng Chen, Zhenghong Zuo
To investigate the serum concentrations of organochlorine pesticides (OCPs) in patients with polycystic ovary syndrome (PCOS), a total of 178 women were studied. The concentrations of hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) in serum were determined using Gas Chromatography Mass-Mass Spectrometer. No differences with statistical significance in the mean HCH, p,p'-DDD, p,p'-DDE concentrations were observed between the patients with PCOS and the control group. Serum p,p'-DDT (P = 0...
December 26, 2016: Chemosphere
https://www.readbyqxmd.com/read/28032054/a-novel-clinical-approach-for-long-term-retention-and-durability-of-resin-restorations-bonded-to-multiple-developmental-defects-of-enamel
#8
Rapala Harika, Brahmananda Dutta, Parsa Arun, Raveen P Teja
Dental enamel is a unique, highly mineralized tissue of ectodermal origin. It is characterized by lack of metabolic activity once formed, implying that disturbances during development can manifest as permanent defects in the erupted tooth. Although the etiology of enamel defects may be attributed to local, systemic, genetic, or environmental factors, most are likely to be multifactorial in nature. The time frame of exposure and the mechanism underpinning the causative factors determine the presentation of these defects...
November 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28011991/hair-analysis-for-the-biomonitoring-of-pesticide-exposure-comparison-with-blood-and-urine-in-a-rat-model
#9
Brice M R Appenzeller, Emilie M Hardy, Nathalie Grova, Caroline Chata, François Faÿs, Olivier Briand, Henri Schroeder, Radu-Corneliu Duca
Urine and plasma have been used to date for the biomonitoring of exposure to pollutants and are still the preferred fluids for this purpose; however, these fluids mainly provide information on the short term and may present a high level of variability regarding pesticide concentrations, especially for nonpersistent compounds. Hair analysis may provide information about chronic exposure that is averaged over several months; therefore, this method has been proposed as an alternative to solely relying on these fluids...
December 23, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27993081/contribution-of-persistent-organic-pollutant-exposure-to-the-adipose-tissue-oxidative-microenvironment-in-an-adult-cohort-a-multipollutant-approach
#10
Francisco Artacho-Cordón, Josefa León, José M Sáenz, Mariana F Fernández, Piedad Martin-Olmedo, Nicolás Olea, Juan P Arrebola
Despite growing in vitro and in vivo evidence of the putative role of persistent organic pollutants (POPs) in the induction of oxidative damage in cell structures, this issue has been poorly addressed from an epidemiologic perspective. The aim of this study was to explore associations between adipose tissue POP concentrations and the in situ oxidative microenvironment. A cross-sectional study was conducted in a subsample (n = 271) of a previously established cohort, quantifying levels of eight POPs and four groups of oxidative stress biomarkers in adipose tissue...
December 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27992738/concentrations-of-organochlorine-pesticides-in-pooled-human-serum-by-age-and-gender
#11
Aleysha Thomas, Leisa-Maree Leontjew Toms, Fiona A Harden, Peter Hobson, Nicole M White, Kerrie L Mengersen, Jochen F Mueller
Organochlorine pesticides (OCPs) have been used for many decades in Australia with cessation of selected persistent and bioaccumulative OCPs ranging from the 1970s to as recently as 2007. The specific aims of this study were to use samples representative of an Australian population to assess age and gender differences in the concentration of OCPs in human blood sera and to investigate temporal trends in these chemicals. Serum was collected from de-identified, surplus pathology samples over five time periods (2002/03, 2006/07, 2008/09, 2010/11 and 2012/13), with 183 serum pools made from 12,175 individual samples; 26 pools in 2002/03, 85 pools in 2006/07 and 24 pools each in 2008/09, 2010/11 and 2012/13...
December 16, 2016: Environmental Research
https://www.readbyqxmd.com/read/27988188/environmental-exposure-to-ddt-and-its-metabolites-in-cord-serum-distribution-enantiomeric-patterns-and-effects-on-infant-birth-outcomes
#12
Chenye Xu, Shanshan Yin, Mengling Tang, Kai Liu, Fangxin Yang, Weiping Liu
Previous in vivo studies have suggested that prenatal exposure to dichlorodiphenyltrichloroethane (DDT) is endocrine disrupting, and may cause adverse health risks to newborns. In this cross-sectional study, non-invasive cord serum samples were collected from maternal-neonate pairs of an island population. Concentrations of DDT and its metabolites were analyzed to provide insights into the environmental exposure patterns and to elucidate their effects on birth outcomes. The average concentrations of p,p'-DDE, o,p'-DDD, p,p'-DDD, o,p'-DDT, p,p'-DDT and total DDTs were 0...
December 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27988186/organochlorine-pesticides-in-tree-bark-and-human-hair-in-yunnan-province-china-concentrations-distributions-and-exposure-pathway
#13
Haodong Yuan, Jun Jin, Yao Bai, Qiuxu Li, Ying Wang, Qinghua Wang
The concentrations and distributions of organochlorine pesticides (OCPs) in West China were investigated and internal and external exposure of humans to OCPs were assessed by analyzing samples of human hair and tree bark collected in Kaiyuan, in Yunnan Province, China. Dichlorodiphenyltrichloroethane and its metabolites (collectively called DDTs), hexachlorocyclohexanes (HCHs), and hexachlorobenzene (HCB) were the dominant OCPs in the human hair and tree bark samples. The mean total DDT, total HCH, and HCB concentrations in the tree bark samples were 298pg/g dry weight (dw), 100pg/g dw, and 183pg/g dw, respectively, and the mean total DDT, total HCH, and HCB concentrations in the hair samples were 2850pg/g dw, 348pg/g dw, and 1026pg/g dw, respectively...
December 14, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27984149/improved-biodegradation-of-synthetic-azo-dye-by-horseradish-peroxidase-cross-linked-on-nano-composite-support
#14
Huaiyan Sun, Xinyu Jin, Nengbing Long, Ruifeng Zhang
A ZnO nanowires/macroporous SiO2 composite was used as support to immobilize horseradish peroxidase (HRP) by in-situ cross-linking method. Using diethylene glycol diglycidyl ether (DDE) as a long-chained cross-linker, it was adsorbed on the surface of ZnO nanowires before reaction with HRPs, the resulted composite was quite different from the traditional cross-linking enzyme aggregates (CLEAs) on both structure and catalytic performance. The immobilized HRP showed high activity in the decolorization of azo dyes...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27974273/anthropogenic-organochlorine-compounds-as-potential-tracers-for-regional-water-masses-a-case-study-of-estuarine-plume-coastal-eddy-wind-driven-upwelling-and-long-range-warm-current
#15
Miaolei Ya, Yuling Wu, Yongyu Li, Xinhong Wang
Water masses are the crucial factor driving the terrigenous anthropogenic organochlorine compounds (OCs) migration from the coast to open sea. Therefore, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were investigated in the Northern South China Sea (NSCS), where different types of water masses are generated by the East Asian summer monsoon: Pearl River estuary plume (PREP), Guangdong offshore eddy (GDEC), South China Sea warm current (SCSWC) and wind-driven upwelling current (WDUC)...
March 2017: Chemosphere
https://www.readbyqxmd.com/read/27939994/oxidative-stress-responses-in-relationship-to-persistent-organic-pollutant-levels-in-feathers-and-blood-of-two-predatory-bird-species-from-pakistan
#16
Naeem Akhtar Abbasi, Augustine Arukwe, Veerle L B Jaspers, Igor Eulaers, Elvira Mennilo, Oju Richard Ibor, Adrien Frantz, Adrian Covaci, Riffat Naseem Malik
To date, knowledge of persistent organic pollutant (POP) mediated oxidative stress responses in avian species is rather limited. We therefore investigated whether exposure to polybrominated diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs) in two predatory bird species, namely black kite (Milvus migrans) and spotted owlet (Athene brama), was associated to activities of antioxidant enzymes, such as glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR) and catalase (CAT), or expression of GPx and superoxide dismutase (SOD) genes...
December 7, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27934256/black-carbon-facilitated-dechlorination-of-ddt-and-its-metabolites-by-sulfide
#17
Kai Ding, Wenqing Xu
1,1-trichloro-2,2-di(4-chlorophenyl)ethane (DDT) and its metabolites 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE), are often detected in soils and sediments containing high concentrations of black carbon. Sulfide (∼5 mM) from biological sulfate reduction often coexists with black carbon and serves as both a strong reductant and a nucleophile for the abiotic transformation of contaminants. In this study, we found that the abiotic transformation of DDT, DDD, and DDE (collectively referred to as DDX) require both sulfide and black carbon...
December 6, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27924835/longitudinal-study-of-pesticide-residue-levels-in-human-milk-from-western-australia-during-12-months-of-lactation-exposure-assessment-for-infants
#18
Jian Du, Zoya Gridneva, Melvin C L Gay, Ching T Lai, Robert D Trengove, Peter E Hartmann, Donna T Geddes
The presence of pesticides in human milk (HM) is of great concern due to the potential health effects for the breastfed infant. To determine the relationships between HM pesticides and infant growth and development, a longitudinal study was conducted. HM samples (n = 99) from 16 mothers were collected at 2, 5, 9 and 12 months of lactation. A validated QuEChERS method and Gas chromatography-tandem mass spectrometry (GC-MS/MS) were used for the analysis of 88 pesticides in HM. Only p,p'-DDE, p,p'-DDT and β-HCH were detected with a mean concentration (±SD) of 52...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922096/enantiomer-signature-and-carbon-isotope-evidence-for-the-migration-and-transformation-of-ddts-in-arable-soils-across-china
#19
Lili Niu, Chao Xu, Siyu Zhu, Huiming Bao, Yang Xu, Hongyi Li, Zhijian Zhang, Xichang Zhang, Jiguo Qiu, Weiping Liu
Due to the adverse impact of DDTs on ecosystems and humans, a full fate assessment deems a comprehensive study on their occurrence in soils over a large region. Through a sampling campaign across China, we measured the concentrations, enantiomeric fractions (EFs), compound-specific carbon isotope composition of DDT and its metabolites, and the microbial community in related arable soils. The geographically total DDT concentrations are higher in eastern than western China. The EFs and δ(13)C of o,p'-DDT in soils from western China show smaller deviations from those of racemic/standard compound, indicating the DDT residues there mainly result from atmospheric transport...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27912912/passive-air-sampling-of-persistent-organic-pollutants-pops-and-emerging-compounds-in-kolkata-megacity-and-rural-mangrove-wetland-sundarban-in-india-an-approach-to-regional-monitoring
#20
Karla Pozo, Santosh Kumar Sarkar, Victor H Estellano, Soumita Mitra, Ondrej Audi, Petr Kukucka, Petra Přibylová, Jana Klánová, Simonetta Corsolini
Polyurethane foam (PUF) disk passive air samplers were deployed concurrently at five sites across Kolkata megacity and the rural mangrove wetland of Sundarban (UNESCO World Heritage Site) between January-March in 2014. Samples were analyzed for hexachlorocyclohexanes (HCHs), dichlorodiphenyltricholoroethanes (DDTs), polychlorinated biphenyls (PCBs) and, polybrominated diphenyl ethers (PBDEs) using gas chromatography and mass spectrometry (GC-MS). Derived air concentrations (pg/m(3)) for Kolkata ranged: for ∑α- and γ-HCH between 70 and 207 (114 ± 62), ∑6DDTs: 127-216 (161 ± 36), ∑7PCBs: 53-213 (141 ± 64), and ∑10PBDEs: 0...
February 2017: Chemosphere
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