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https://www.readbyqxmd.com/read/28616737/serum-concentrations-of-selected-organochlorine-pesticides-in-a-lebanese-population-and-their-associations-to-sociodemographic-anthropometric-and-dietary-factors-enasb-study
#1
Mireille Harmouche-Karaki, Joseph Matta, Khalil Helou, Yara Mahfouz, Nicole Fakhoury-Sayegh, Jean-François Narbonne
Organochlorine pesticides (OCPs) were banned by the Stockholm Convention many years ago; however, they are still detected in the environment due to their high persistence, their current illegal use, and their import from countries where they have not been banned. We evaluated the serum concentrations of selected OCPs (hexachlorobenzene (HCB), β-hexachlorocyclohexanes (β-HCH), p,p'-dichlorodiphenyltrichloroethane (DDT) and its metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in a sample of Lebanese adults using gas chromatography coupled to an ion trap mass spectrometer detector...
June 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28610584/serum-levels-of-environmental-pollutants-is-a-risk-factor-for-breast-cancer-in-inuit-a-case-control-study
#2
Maria Wielsøe, Peder Kern, Eva Cecilie Bonefeld-Jørgensen
BACKGROUND: Environmental Persistent Organic Pollutants (POPs) can alter the hormone homeostasis by mimicking, interfering or blocking the function of hormones; moreover POPs are hypothesized to modify the risk of breast cancer. The association between POPs and breast cancer has been widely studied but the conclusions are inconsistent. The present study examined the associations between serum levels of POPs and breast cancer with focus on the highly exposed Greenlandic Inuit population...
June 13, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28573557/synthesis-of-the-ddt-metabolite-2-4-dichloro-1-2-chloro-1-4-chlorophenyl-ethenyl-benzene-o-cl-ddmu-and-its-detection-in-abiotic-and-biotic-samples
#3
Christoph Gallistl, Katie Proctor, Korinna Bader, Walter Vetter
Technical dichlorodiphenyltrichloroethane (DDT) has been used worldwide as a pesticide since the beginning of the 1940s. Due to its persistence, DDT residues are still ubiquitously distributed in the environment. Photochemical UV degradation has been shown to be a potent degradation path for DDT and most of the resulting photoproducts have been identified up to now. Nevertheless, in 2012, a new DDT metabolite, most likely formed photochemically from DDE, was detected in ray liver samples from Brazil, an area which is highly contaminated with DDT...
June 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28572628/adipose-tissue-dysfunction-as-a-central-mechanism-leading-to-dysmetabolic-obesity-triggered-by-chronic-exposure-to-p-p-dde
#4
Diogo Pestana, Diana Teixeira, Manuela Meireles, Cláudia Marques, Sónia Norberto, Carla Sá, Virgínia C Fernandes, Luísa Correia-Sá, Ana Faria, Luísa Guardão, João T Guimarães, Wendy N Cooper, Ionel Sandovici, Valentina F Domingues, Cristina Delerue-Matos, Rosário Monteiro, Miguel Constância, Conceição Calhau
Endocrine-disrupting chemicals such as p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic context. We explored the effects of 12 weeks exposure in male Wistar rats' metabolism and AT biology, assessing a range of metabolic, biochemical and histological parameters. p,p'-DDE -treatment exacerbated several of the metabolic syndrome-accompanying features induced by high-fat diet (HF), such as dyslipidaemia, glucose intolerance and hypertension...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28569776/hiv-integrase-inhibitor-elvitegravir-impairs-rag-functions-and-inhibits-v-d-j-recombination
#5
Mayilaadumveettil Nishana, Namrata M Nilavar, Rupa Kumari, Monica Pandey, Sathees C Raghavan
Integrase inhibitors are a class of antiretroviral drugs used for the treatment of AIDS that target HIV integrase, an enzyme responsible for integration of viral cDNA into host genome. RAG1, a critical enzyme involved in V(D)J recombination exhibits structural similarity to HIV integrase. We find that two integrase inhibitors, Raltegravir and Elvitegravir, interfered with the physiological functions of RAGs such as binding, cleavage and hairpin formation at the recombination signal sequence (RSS), though the effect of Raltegravir was limited...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28545729/development-of-fast-efficient-and-ecological-method-employing-vortex-assisted-dispersive-liquid-liquid-microextraction-combined-with-fast-gas-chromatography-mass-spectrometry-for-pesticide-residues-analysis-in-alcohol-content-samples
#6
Svetlana Hrouzková, Mária Brišová, Agneša Szarka
A fast, ecological, and efficient method employing vortex-assisted dispersive liquid-liquid microextraction (DLLME) method for isolation and preconcentration of selected endocrine disrupting pesticides from beverages containing some degree of alcohol was developed. The effect of several extraction parameters, such as selection of extractive solvent, its volume and extraction time, the salt addition was investigated. Four different extractive solvents (chloroform, tetrachloroethane, tetrachloromethane and toluene) and their combinations were evaluated for DLLME...
May 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28540444/organochlorine-pesticides-residues-in-human-breast-milk-from-the-middle-governorates-in-jordan-in-2013-2014
#7
Tawfiq M Al Antary, Mahmoud A Alawi, Hussein Estityah, Nizar Haddad
One hundred samples of mother breast milk were gathered from six middle governorates and districts in Jordan in 2013/2014 to monitor Organochlorine pesticides pollutants. The results showed clearly that banned organochlorine pesticides are still detected in the monitored samples in low concentration despite banning of these persistent pollutants in Jordan since 36 years ago. However, the results indicated that 1% of the contaminated samples contained β-HCH, 5% γ-HCH, 3% p,p'-DDD, 2% heptachlor, 45% p,p'-DDE and 3% p,p'-DDT...
May 24, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28536421/assessment-of-tissue-specific-accumulation-elimination-and-toxic-effects-of-dichlorodiphenyltrichloroethanes-ddts-in-carp-through-aquatic-food-web
#8
Shanshan Di, Ruiquan Liu, Zhongnan Tian, Cheng Cheng, Li Chen, Wenjun Zhang, Zhiqiang Zhou, Jinling Diao
Microcosms containing DDT spiked-sediment, Tubifex tubifex and carp (Cyprinus carpio) were constructed to simulate a freshwater system. The accumulation, elimination and toxic effects of DDT (p,p'-DDT, o,p'-DDT), and its metabolites DDD (p,p'-DDD, o,p'-DDD) and DDE (p,p'-DDE, o,p'-DDE) were studied in T. tubifex and carp. Tissue/organ distributions of DDTs were also investigated in carp. The bioaccumulation and elimination of DDT differed in T. tubifex, carp and its tissues/organs. Unimodal or bimodal distributions were observed, and the concentrations of DDT metabolites (DDD and p,p'-DDE) increased over time...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28528414/tissue-contaminant-burdens-in-san-francisco-estuary-white-sturgeon-acipenser-transmontanus-implications-for-population-recovery
#9
Deke T Gundersen, Steven C Zeug, Robert B Bringolf, Joseph Merz, Zachary Jackson, Molly A H Webb
The San Francisco Estuary (SFE) is heavily influenced by anthropogenic activities, including historic and chronic contaminant inputs. These contaminants can adversely affect SFE fish populations, particularly white sturgeon, because they are a benthic dwelling, long-lived species. We measured a suite of metals and organic contaminants in liver and gonad tissues of 25 male and 32 female white sturgeon as well as several physiological indicators of sturgeon health. Most sturgeon (68% of males and 83% of females) were estimated to be between 13 and 17 years of age...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28525872/levels-and-temporal-trends-of-organochlorine-contaminants-in-mussels-from-spanish-mediterranean-waters
#10
Juan A Campillo, Beatriz Fernández, Víctor García, José Benedicto, Víctor M León
The levels and trends of organochlorine contaminants were determined along the Spanish Mediterranean coast from 2000 to 2013 using mussel, Mytilus galloprovincialis, as bioindicator species. The highest levels of PCBs and DDTs were found at industrial and urban locations, and at areas under the influence of the mouth of major rivers. Dieldrin and t-NNC were commonly detected, while HCHs, aldrin, isodrin, endrin and HCB were at levels not detectable at many areas. Significant declines on the levels of DDTs were observed at most of the areas studied...
May 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28522354/corrigendum-to-differential-effects-of-the-persistent-ddt-metabolite-methylsulfonyl-dde-in-nonstimulated-and-lh-stimulated-neonatal-porcine-leydig-cells-toxicol-appl-pharmacol-267-2013-247-255
#11
Cesilie Granum Castellanos, Irene Beate Sørvik, Marte Bruu Tanum, Steven Verhaegen, Ingvar Brandt, Erik Ropstad
No abstract text is available yet for this article.
May 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28490090/effects-of-pan-cooking-on-micropollutants-in-meat
#12
Christelle Planche, Jérémy Ratel, Patrick Blinet, Frédéric Mercier, Magaly Angénieux, Claude Chafey, Julie Zinck, Nathalie Marchond, Sylvie Chevolleau, Philippe Marchand, Gaud Dervilly-Pinel, Thierry Guérin, Laurent Debrauwer, Erwan Engel
This work presents the effects of pan cooking on PCBs, PCDD/Fs, pesticides and trace elements in meat from a risk assessment perspective. Three different realistic cooking intensities were studied. A GC×GC-TOF/MS method was set up for the multiresidue analysis of 189 PCBs, 17 PCDD/Fs and 16 pesticides whereas Cd, As, Pb and Hg were assayed by ICP-MS. In terms of quantity, average PCB losses after cooking were 18±5% for rare, 30±3% for medium, and 48±2% for well-done meat. In contrast, average PCDD/F losses were not significant...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28483709/exposure-to-ddt-and-its-metabolites-from-khat-catha-edulis-chewing-consumers-risk-assessment-from-southwestern-ethiopia
#13
Seblework Mekonen, Argaw Ambelu, Belay Negassa, Pieter Spanoghe
Khat (Catha edulis) is one of the most consumed plant in the horn of African countries. However, it is a stimulant plant that has several side effects on the health of consumers. On top of that, the khat leaves used for human consumption are often contain contaminants such as pesticide residues. The present study aims to investigate the level of DDT residue and its metabolites (p'p-DDE, p'p-DDD, o'p-DDT and p'p-DDT) in khat samples and to undertake exposure assessment to consumers. The khat samples were collected from local markets in southwestern Ethiopia...
May 5, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28482294/association-between-fish-consumption-dietary-omega-3-fatty-acids-and-persistent-organic-pollutants-intake-and-type-2-diabetes-in-18-first-nations-in-ontario-canada
#14
Lesya Marushka, Malek Batal, William David, Harold Schwartz, Amy Ing, Karen Fediuk, Donald Sharp, Andrew Black, Constantine Tikhonov, Hing Man Chan
BACKGROUND: First Nations (FNs) populations in Canada experience a disproportionally higher rate of obesity and type 2 diabetes (T2D) compared to the general population. Recent data suggest that a high consumption of fish may help prevent T2D. On the other hand, fish might also be a potential source of environmental contaminants which could potentially be a risk factor for T2D. OBJECTIVE: To investigate the potential associations between self-reported T2D and consumption of locally-harvested fish, dietary long-chain omega-3 fatty acids (n-3FAs) and persistent organic pollutants intake among adult FNs living on reserve in Ontario...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28482040/transposition-of-mutator-like-transposable-elements-mules-resembles-hat-and-transib-elements-and-v-d-j-recombination
#15
Kun Liu, Susan R Wessler
Mutator-like transposable elements (MULEs) are widespread across fungal, plant and animal species. Despite their abundance and importance as genetic tools in plants, the transposition mechanism of the MULE superfamily was previously unknown. Discovery of the Muta1 element from Aedes aegypti and its successful transposition in yeast facilitated the characterization of key steps in Muta1 transposition. Here we show that purified transposase binds specifically to the Muta1 ends and catalyzes excision through double strand breaks (DSB) and the joining of newly excised transposon ends with target DNA...
May 8, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28476008/breast-milk-intake-and-mother-to-infant-pesticide-transfer-measured-by-deuterium-oxide-dilution-in-agricultural-and-urban-areas-of-mexico
#16
Ana Teresa Limon-Miro, Maria Lourdes Aldana-Madrid, Gerardo Alvarez-Hernandez, Lesley Evelyn Antunez-Roman, Guillermo Rodriguez-Olibarria, Mauro E Valencia Juillerat
Vector-borne diseases have increased pesticide use in urban areas (UA) and agricultural areas (AA) in Mexico. Breast milk can be contaminated by pesticide exposure. The objective of the study was to measure breast milk intake by deuterium oxide dilution as well as organochlorine and pyrethroid transfer from mother to infant in AA and UA of Sonora, Mexico. Human milk intake was determined by the 'dose-to-mother' technique using deuterium oxide (D2O) dilution. Mothers' body composition was also assessed by this technique and the intercept method...
April 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28463822/organochlorine-pesticides-and-polychlorinated-biphenyls-in-human-adipose-tissue-from-northern-tunisia-current-extent-of-contamination-and-contributions-of-socio-demographic-characteristics-and-dietary-habits
#17
Amani Achour, Abdelkader Derouiche, Badreddine Barhoumi, Badreddine Kort, Driss Cherif, Sondes Bouabdallah, Mohsen Sakly, Khémais Ben Rhouma, Soufiane Touil, Mohamed Ridha Driss, Olfa Tebourbi
The aims of the present study were to investigate the current exposure levels of persistent organochlorine compounds (OCs) in adipose tissues intraoperatively collected from 40 patients over 20 years undergoing non-cancer-related surgery residing in Northern region of Tunisia (Bizerte), which constitutes an exemplary case, and examined association between levels of contamination and both socio-demographic characteristics and dietary habits. Concentration of hexachlorobenzene (HCB), hexachlorocyclohexane isomers (α-HCH, β-HCH, γ-HCH and δ-HCH), dichlorodiphenyltrichloroethane isomers (p,p'-DDT and o,p'-DDT) and metabolites (p,p'-DDE, o,p'-DDE, p,p'-DDD and o,p'-DDD) and 12 polychlorinated biphenyls (PCBs) congeners were measured using capillary gas chromatography with electron capture detector...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28460875/persistent-organochlorine-residues-in-fish-and-sediments-collected-from-eastern-aegean-coast-levels-occurrence-and-ecological-risk
#18
Shareef K I Muzyed, Filiz Kucuksezgin, Nalan Tuzmen
Organochlorines were determined in fish and sediment collected from Izmir and Çandarlı Bays. The results indicated that ΣCyclodiens were generally predominant contaminants. In all samples, p,p'-DDE was the predominant DDT congener. Aroclors were found in noticeably higher levels than OCPs in sediment and the highest levels of Aroclors, OCPs were found in Nemrut which can be attributed to industrial activities. According to Sediment Quality Guidelines, DDTs were lower than the values that may cause adverse biological risk in sediment samples...
April 28, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28460236/trophic-ecology-drives-contaminant-concentrations-within-a-tropical-seabird-community
#19
Manrico Sebastiano, Paco Bustamante, Igor Eulaers, Govindan Malarvannan, Paula Mendez-Fernandez, Carine Churlaud, Pierre Blévin, Antoine Hauselmann, Adrian Covaci, Marcel Eens, David Costantini, Olivier Chastel
To support environmental management programs, there is an urgent need to know about the presence and understand the dynamics of major contaminants in seabird communities of key marine ecosystems. In this study, we investigated the concentrations and trophodynamics of trace elements in six seabird species and persistent organic pollutants (POPs) in three seabird species breeding on Grand Connétable Island (French Guiana), an area where the increase in human population and mining activities has raised concerns in recent years...
August 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28456124/serum-levels-of-organochlorine-pesticides-in-blood-donors-a-biomonitoring-survey-in-the-north-of-brazil-2010-2011
#20
Carmen Freire, Rosalina Jorge Koifman, Sergio Koifman
Data on exposure to organochlorine (OC) pesticides in the Brazilian population are lacking. The purpose of this study was to investigate the distribution of serum levels of OC pesticides in Brazilian blood donors and to determine factors potentially influencing exposure levels. To conduct this biomonitoring survey, blood samples were collected from blood donors attending the Hematherapic Unit in Rio Branco, North of Brazil, in 2010-2011. A total of 1183 (99%) subjects answered to a questionnaire including information on sociodemographics, lifestyle, and dietary habits...
November 15, 2017: Science of the Total Environment
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