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https://www.readbyqxmd.com/read/28530511/wnt-signaling-related-osteokines-and-transforming-growth-factors-before-and-after-a-single-bout-of-plyometric-exercise-in-child-and-adolescent-females
#1
Jennifer Dekker, Katlynne Nelson, Nigel Kurgan, Bareket Falk, Andrea Josse, Panagiota Klentrou
This study examined resting levels of catabolic and anabolic osteokines related to Wnt signaling and their responses to a single bout of plyometric exercise in child and adolescent females. Fourteen pre-menarcheal girls (10.5 ± 1.8 years old) and 12 post-menarcheal adolescent girls (15.0 ± 1.0 years old) performed a plyometric exercise trial. One resting and three post-exercise blood samples (5 min, 1h, 24h post-exercise) were analysed for sclerostin (SOST), dickkopf-1 (DKK-1), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-β ligand (RANKL) and transforming growth factors (TGF-β1, TGF-β2 and TGF-β3)...
May 22, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28529658/pinning-the-slipped-and-contralateral-hips-in-the-treatment-of-slipped-capital-femoral-epiphysis
#2
G Hägglund
PURPOSE: To describe and comment on the treatment of the slipped capital femoral epiphysis (SCFE) with pinning and to present the pros and cons of prophylactic pinning of the contralateral hip. SUMMARY: Pinning the SCFE aims to fix the epiphysis and prevent further slipping. Some devices allow for further growth and remodeling of the femoral neck post-operatively. This results in maintained femoral offset and probably reduced risk of femoroacetabular impingement...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28529397/behavior-problems-and-children-s-academic-achievement-a-test-of-growth-curve-models-with-gender-and-racial-differences
#3
Kristen P Kremer, Andrea Flower, Jin Huang, Michael G Vaughn
The aim of this study was to examine the longitudinal association between externalizing and internalizing behavior and children's academic achievement, particularly in terms of whether these variables varied as a function of gender and race. Data pertaining to externalizing and internalizing behavior, academic achievement, gender, and race from three waves of the Child Development Supplement of the Panel Study of Income Dynamics (N = 2028) were used. Results indicate that behavior problems had a negative relationship with academic performance and some of these associations endured over time...
August 2016: Children and Youth Services Review
https://www.readbyqxmd.com/read/28529275/safety-and-effectiveness-of-long-term-growth-hormone-therapy-in-japanese-patients-with-adult-growth-hormone-deficiency-a-postmarketing-multicenter-observational-study
#4
Akira Shimatsu, Hitoshi Ishii, Hiromi Nishinaga, Osamu Murai, Kazuo Chihara
We aimed to evaluate the long-term safety and effectiveness of growth hormone (GH) therapy in Japanese patients with adult growth hormone deficiency (AGHD). In this observational, multicenter study, Norditropin(®) (Novo Nordisk A/S, Bagsvaerd, Denmark) was administered as injections of 0.021 mg/kg/week as a starting dose divided into 6-7 doses/week. The dose was increased according to clinical response. Patients' data were obtained from medical records. Measurements (lipids, glucose metabolism, and body composition) taken at baseline; 3, 6, and 12 months; and yearly until the end of the study were collected...
May 19, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28528598/the-emergence-of-personal-growth-amongst-healthcare-professionals-who-care-for-dying-children
#5
Laura Beaune, Barbara Muskat, Samantha J Anthony
OBJECTIVE: Compassion fatigue, burnout, and vicarious traumatization are prominent topics in the current literature on the impact of the rewarding but challenging work of healthcare professionals who care for patients with life-limiting illnesses. The positive effects of caregiving constitute a newly emerging outcome that has been relatively unexplored in the pediatric literature, and yet they may play an important role in contributing to the satisfaction and well-being of the healthcare professionals who care for children who have a life-limiting illness...
May 22, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28527745/early-life-protein-intake-food-sources-correlates-and-tracking-across-the-first-5-years-of-life
#6
Karen J Campbell, Gavin Abbott, Miaobing Zheng, Sarah A McNaughton
BACKGROUND: High consumption of protein has been associated with accelerated growth and adiposity in early childhood. OBJECTIVE: To describe intake, food sources, correlates, and tracking of protein in young children. DESIGN: Secondary analysis of Melbourne Infant Feeding Activity and Nutrition Trial (InFANT). Dietary data were collected using three 24-hour dietary recalls at ages 9 and 18 months as well as 3.5 and 5 years. PARTICIPANTS/SETTING: First-time mothers and their child (n=542) participated in an 18-month intervention to prevent childhood obesity and the cohort was followed-up with no intervention when children were aged 3...
May 16, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28523647/computational-investigation-of-growth-hormone-receptor-trp169arg-heterozygous-mutation-in-a-child-with-short-stature
#7
William Farias Porto, Felipe Albuquerque Marques, Huri Brito Pogue, Maria Teresinha de Oliveira Cardoso, Maria Gabriela Rodrigues do Vale, Állan da Silva Pires, Octavio Luiz Franco, Sérgio Amorim de Alencar, Robert Pogue
Mutations in the growth hormone receptor (GHR) gene can cause disruption of the growth hormone signaling pathway, resulting in growth deficiency due to growth hormone (GH) resistance. Both recessive and apparently dominant mutations have been described in the literature. In order to shed some light on the molecular mechanism of partial growth hormone resistance caused by heterozygous mutations we performed an in-depth in silico analysis of a mutation found in a girl with a previous diagnosis of idiopathic short stature...
May 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28523540/rubinstein-taybi-syndrome-and-epigenetic-alterations
#8
Edward Korzus
Rubinstein-Taybi syndrome (RSTS) is a rare genetic disorder in humans characterized by growth and psychomotor delay, abnormal gross anatomy, and mild to severe mental retardation (Rubinstein and Taybi, Am J Dis Child 105:588-608, 1963, Hennekam et al., Am J Med Genet Suppl 6:56-64, 1990). RSTS is caused by de novo mutations in epigenetics-associated genes, including the cAMP response element-binding protein (CREBBP), the gene-encoding protein referred to as CBP, and the EP300 gene, which encodes the p300 protein, a CBP homologue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28521627/disseminated-bacillus-calmette-gu%C3%A3-rin-osteomyelitis-in-twin-sisters-related-to-stat1-gene-deficiency
#9
Sabah Boudjemaa, Linda Dainese, Sébastien Héritier, Caroline Masserot, Samia Hachemane, Jean-Laurent Casanova, Aurore Coulomb, Jacinta Bustamante
Mendelian susceptibility to mycobacterial disease is a rare syndrome characterized by severe clinical infections usually caused by weakly virulent mycobacterial species such as Bacillus Calmette-Guérin vaccines and environmental nontuberculous mycobacteria or more virulent mycobacteria as mycobacterium tuberculosis. Since 1996, 9 genes including 7 autosomal ( STAT1, IFNGR1, IFNGR2, IL12B, IL12RB1, ISG15, and IRF8) and 2 X-linked genes ( NEMO and CYBB) have been identified. Allelic heterogeneity leaded to recognize about 18 genetic diseases with variable clinical phenotypes, but sharing a same physiological mechanism represented by a defect in human IL-12-dependant-INF-γ-mediated immunity...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28521318/breastfeeding-childhood-asthma-and-allergic-disease
#10
Wendy H Oddy
The worldwide prevalence of childhood asthma has been increasing considerably, and the protection afforded by breastfeeding in its development has been the subject of controversy for more than 80 years. Previous systematic reviews have generally found a protective effect of breastfeeding on allergic outcomes, although many studies have methodological limitations. Although breastfeeding is protective against lower respiratory tract infection during infancy, such protection has not been demonstrated for asthma in all studies...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28520809/antenatal-coffee-and-tea-consumption-and-the-effect-on-birth-outcome-and-hypertensive-pregnancy-disorders
#11
Timothy van der Hoeven, Joyce L Browne, Cuno S P M Uiterwaal, Cornelis K van der Ent, Diederick E Grobbee, Geertje W Dalmeijer
BACKGROUND AND OBJECTIVE: Coffee and tea are commonly consumed during pregnancy. While several of their components, like caffeine, have strong pharmacological effects, the effect on the unborn fetus remains unclear. Caffeine intake has been associated with abortion, preterm birth and fetal growth restriction, but a general consensus on caffeine restriction is still lacking. We aimed to investigate antenatal coffee, tea and caffeine consumption and the effect on birth weight and length, gestational age at birth and hypertensive disorders in pregnancy...
2017: PloS One
https://www.readbyqxmd.com/read/28516786/association-of-angiogenic-cytokines-vegf-a-and-vegf-c-and-clinical-characteristic-in-women-with-unexplained-recurrent-miscarriage
#12
A Bagheri, P Kumar, A Kamath, P Rao
INTRODUCTION: Recurrent miscarriage (RM) defined as 2 or more spontaneous miscarriage before 20 weeks of gestation, affects at least 1 % of couples trying to conceive. In over 50 % of cases, the cause of the loss of pregnancy remains unexplained. Reduced expression of Angiogenic factors such as: vascular endothelial growth factor (VEGF-A) and VEGF-C has been linked with spontaneous miscarriage, likely due to defective foetal and placental angiogenesis. AIMS AND OBJECTIVES: To investigate the relationships between serum level of VEGF-A and VEGF-C with clinical characteristic in women with URM and compare to pregnant and healthy women...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28514143/community-level-sanitation-coverage-is-more-strongly-associated-with-child-growth-and-household-drinking-water-quality-than-access-to-a-private-toilet-in-rural-mali
#13
Michael Harris, Maria Laura Alzua, Nicolas Osbert, Amy J Pickering
Sanitation access can provide positive externalities; for example, safe disposal of feces by one household prevents disease transmission to households nearby. However, little empirical evidence exists to characterize the potential health benefits from sanitation externalities. This study investigated the effect of community sanitation coverage versus individual household sanitation access on child health and drinking water quality. Using a census of 121 villages in rural Mali, we analyzed the association of community latrine coverage (defined by a 200-meter radius surrounding a household) and individual household latrine ownership with child growth and household stored water quality...
May 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28514134/-well-child-visits-regarding-growth-and-development-of-infants-a-cross-cultural-comparison
#14
Yana Shraga, Orly Sarid, Julie Cwikel, Haim Reuveni
AIMS: 1. To examine the rate of WCV among mothers in four ethno-cultural groups: native-born Jewish, Bedouin and immigrants from the Former Soviet Union (FSU) and Ethiopia; 2. to test the relationship between WCV in the first and second year of the infant's life; 3. to assess the effect of sociodemographic variables on WCV. BACKGROUND: Consistent infant well-child visits (WCV) have been found to be related to better health status and a decrease in visits to the emergency room and hospitalizations...
July 2016: Harefuah
https://www.readbyqxmd.com/read/28512260/targeting-metabolism-and-amp-activated-kinase-with-metformin-to-sensitize-non-small-cell-lung-cancer-nsclc-to-cytotoxic-therapy-translational-biology-and-rationale-for-current-clinical-trials
#15
REVIEW
Michael Troncone, Stephanie M Cargnelli, Linda A Villani, Naghmeh Isfahanian, Lindsay A Broadfield, Laura Zychla, Jim Wright, Gregory Pond, Gregory R Steinberg, Theodoros Tsakiridis
Lung cancer is the most fatal malignancy worldwide, in part, due to high resistance to cytotoxic therapy. There is need for effective chemo-radio-sensitizers in lung cancer. In recent years, we began to understand the modulation of metabolism in cancer and its importance in tumor progression and survival after cytotoxic therapy. The activity of biosynthetic pathways, driven by the Growth Factor Receptor/Ras/PI3k/Akt/mTOR pathway, is balanced by the energy stress sensor pathway of LKB1/AMPK/p53. AMPK responds both to metabolic and genotoxic stress...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28510596/utilization-of-growth-monitoring-and-promotion-services-and-associated-factors-among-under-two-years-of-age-children-in-southern-ethiopia
#16
Fentaw Wassie Feleke, Anchamo Anato Adole, Afework Mulugeta Bezabih
Growth monitoring and promotion (GMP) is a prevention activity comprised of growth monitoring (GM) linked with promotion that serves as the core activity in an integrated child health and nutrition program. However, different methods of institutional studies have shown that utilization of GM services has remained to be inadequate. There is scarcity of studies conducted about GMP in quantitative method. Therefore, this study was conducted to address the proportion of GMP services and associated factors among children under two years of age in rural communities of Mareka district, Southern Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28508738/social-ecological-predictors-of-externalizing-behavior-trajectories-in-at-risk-youth
#17
Caleb J Figge, Cecilia Martinez-Torteya, Jessica E Weeks
Extant research consistently links youth externalizing problems and later maladaptive outcomes, and these behaviors are particularly detrimental given their relative stability across development. Although an array of risk and protective factors for externalizing problems have been identified, few studies have examined factors reflecting the multiple social-ecological levels that influence child development and used them to predict longitudinal trajectories of externalizing problems. The current study examined externalizing behavior trajectories in a sample of 1,094 at-risk youth (539 boys, 555 girls) from the Longitudinal Studies in Child Abuse and Neglect multisite longitudinal study of child maltreatment...
May 16, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28498315/factors-associated-with-stunting-among-children-aged-0-to-59-months-from-the-central-region-of-mozambique
#18
Loida M García Cruz, Gloria González Azpeitia, Desiderio Reyes Súarez, Alfredo Santana Rodríguez, Juan Francisco Loro Ferrer, Lluis Serra-Majem
The objective of this study was to identify the major socio-demographic, health, and environmental determinants of stunting among children aged 0-59 months from the Tete province (Mozambique) and offering useful information for future healthcare strategies and interventions. A case-control study was conducted among 282 (162 boys; 120 girls) children under five years of age from the central region of Mozambique between 1 May and 3 June 2014. Children with stunting (HAZ < -2 SD according to the WHO Child Growth Standards in 2006) were considered as cases and those who had a Z-score < -2 SD were considered as controls...
May 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28497581/what-could-cognitive-capital-mean-for-china-s-children
#19
Douglas J Noble, Kathryn Martin, Lisa Qin, Pia Britto, Margo O'sullivan, Jillian Popkins, Ron Pouwels, Robert W Scherpbier, Rana Flowers
Cognitive capital is an emerging paradigm that captures the criticality of investing in children whilst neural proliferation and development of brain architecture are at their peak. Distinct from financial capital, cognitive capital represents investment in future human potential from interventions in nutrition, health, education, child protection, and social welfare systems that optimize brain development. The return on investment is significant given the plasticity of the developing brain in response to positive stimuli...
May 12, 2017: PsyCh Journal
https://www.readbyqxmd.com/read/28497491/male-child-with-somatic-mosaic-osteopathia-striata-with-cranial-sclerosis-caused-by-a-novel-pathogenic-amer1-frameshift-mutation
#20
Jennifer Hague, Isabelle Delon, Kim Brugger, Howard Martin, Leanne Sparnon, Ingrid Simonic, Stephen Abbs, Soo-Mi Park
Osteopathia striata with cranial sclerosis (OSCS; OMIM #300373) is a rare X-linked dominant condition caused by mutations in the AMER1 gene (also known as WTX or FAM123B). It is a condition which usually affects females in whom the clinical phenotype can be extremely variable. Conversely affected males typically die in utero or during the neonatal period [Perdu et al. (); Clinical Genetics 80: 383-388; Vasiljevic et al. (); Prenatal Diagnosis 35: 302-304]. There have been a small number of reported cases of surviving males, including three patients who are somatic mosaic for the condition [Chénier, Noor, Dupuis, Stavropoulos, & Mendoza-Londono, (); American Journal of Medical Genetics Part A 158A: 2946-2952; Holman et al...
May 12, 2017: American Journal of Medical Genetics. Part A
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