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https://www.readbyqxmd.com/read/28449234/magnetic-resonance-imaging-and-computed-tomographic-characteristics-of-a-glioma-causing-calvarial-erosion-in-a-dog
#1
Alfredo Recio, Cristian de la Fuente, Martí Pumarola, Yvonne Espada, Sònia Añor
An 8-year-old female Boxer was examined for acute onset of seizures. On magnetic resonance imaging (MRI), an intra-axial mass with imaging features consistent with glioma was observed in the right cerebral hemisphere. A defect in the temporal bone adjacent to the mass was observed. Postmortem computed tomography (CT) confirmed temporal bone osteolysis and necropsy demonstrated a glioblastoma with associated calvarial erosion. Although occasionally described in human medicine, to our knowledge, this is the first description of a brain glioma causing calvarial erosion in a dog...
April 27, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28448856/impact-of-a-risk-based-follow-up-in-patients-affected-by-gastrointestinal-stromal-tumour
#2
Lorenzo D'Ambrosio, Erica Palesandro, Paola Boccone, Francesco Tolomeo, Sara Miano, Danilo Galizia, Antonio Manca, Gabriele Chiara, Ilaria Bertotto, Filippo Russo, Delia Campanella, Tiziana Venesio, Dario Sangiolo, Ymera Pignochino, Dimitrios Siatis, Michele De Simone, Alessandro Ferrero, Alberto Pisacane, Angelo Paolo Dei Tos, Sandra Aliberti, Massimo Aglietta, Giovanni Grignani
BACKGROUND: Follow-up aims to precociously identify recurrences, metastases or treatment-related adverse events so as to undertake the appropriate therapy. Guidelines admit lack of knowledge on optimal surveillance schedule, but suggest follow-up based on experts' opinion and risk stratification. To identify the impact, if any, of regular follow-up, we interrogated our prospectively collected database whether early detection of recurrences affected both clinical management and, likely, the outcome...
April 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28448411/image-quality-and-radiation-exposure-comparison-of-a-double-high-pitch-acquisition-for-coronary-computed-tomography-angiography-versus-standard-retrospective-spiral-acquisition-in-patients-with-atrial-fibrillation
#3
Carlos Eduardo Elias Dos Prazeres, Tiago Augusto Magalhães, Adriano Camargo de Castro Carneiro, Roberto Caldeira Cury, Valéria de Melo Moreira, Juliana Hiromi Silva Matsumoto Bello, Carlos Eduardo Rochitte
OBJECTIVE: The aim of this study was to compare image quality and radiation dose of coronary computed tomography (CT) angiography performed with dual-source CT scanner using 2 different protocols in patients with atrial fibrillation. METHODS: Forty-seven patients with AF underwent 2 different acquisition protocols: double high-pitch (DHP) spiral acquisition and retrospective spiral acquisition. The image quality was ranked according to a qualitative score by 2 experts: 1, no evident motion; 2, minimal motion not influencing coronary artery luminal evaluation; and 3, motion with impaired luminal evaluation...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28447562/dosimetric-advantages-of-a-clinical-daily-adaptive-plan-selection-strategy-compared-with-a-non-adaptive-strategy-in-cervical-cancer-radiation-therapy
#4
Agustinus J A J van de Schoot, Peter de Boer, Jorrit Visser, Lukas J A Stalpers, Coen R N Rasch, Arjan Bel
BACKGROUND: Radiation therapy (RT) using a daily plan selection adaptive strategy can be applied to account for interfraction organ motion while limiting organ at risk dose. The aim of this study was to quantify the dosimetric consequences of daily plan selection compared with non-adaptive RT in cervical cancer. MATERIAL AND METHODS: Ten consecutive patients who received pelvic irradiation, planning CTs (full and empty bladder), weekly post-fraction CTs and pre-fraction CBCTs were included...
May 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28447434/the-influence-of-different-muscle-mass-measurements-on-the-diagnosis-of-cancer-cachexia
#5
Susanne Blauwhoff-Buskermolen, Jacqueline A E Langius, Annemarie Becker, Henk M W Verheul, Marian A E de van der Schueren
BACKGROUND: Progressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass on the diagnosis of cancer cachexia. In addition, the association of cachexia with other features of cachexia, quality of life, and survival was explored. METHODS: Prior to chemotherapy, cachexia was assessed by weight loss, body mass index, and muscle mass measurements, the latter by mid-upper arm muscle area (MUAMA), computed tomography (CT) scans, and bio-electrical impedance analysis (BIA)...
April 26, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28447218/pertuzumab-trastuzumab-ct-versus-trastuzumab-ct-therapy-for-her2-breast-cancer-results-from-the-prospective-neoadjuvant-breast-registry-symphony-trial-nbrst
#6
Peter Beitsch, Pat Whitworth, Paul Baron, Michael C Rotkis, Angela M Mislowsky, Paul D Richards, Mary K Murray, James V Pellicane, Carrie L Dul, Charles H Nash, Lisette Stork-Sloots, Femke de Snoo, Sarah Untch, Laura A Lee
BACKGROUND: Pertuzumab became a standard part of neoadjuvant therapy for human epidermal growth factor receptor 2-positive (HER2+) breast cancers approximately halfway through Neoadjuvant Breast Registry Symphony Trial (NBRST) enrollment, providing a unique opportunity to determine biologically which clinical HER2+ patients benefit most from dual targeting. As a neoadjuvant phase 4 study, NBRST classifies patients by both conventional and molecular subtyping. METHODS: Of 308 clinical HER2+ patients enrolled in NBRST between 2011 and 2014 from 62 U...
April 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28444508/study-protocol-on-the-role-of-intestinal-microbiota-in-colorectal-cancer-treatment-a-pathway-to-personalized-medicine-2-0
#7
R Aarnoutse, J M P G M de Vos-Geelen, J Penders, E G Boerma, F A R M Warmerdam, B Goorts, S W M Olde Damink, Z Soons, S S M Rensen, M L Smidt
PURPOSE: Investigate in patients with metastatic and/or irresectable colorectal cancer treated with systemic treatment with capecitabine or TAS-102 whether: 1. Intestinal microbiota composition can act as a predictor for response. 2. Intestinal microbiota composition changes during systemic treatment and its relation to chemotoxicity. BACKGROUND: Gut microbiota and host determinants evolve in symbiotic and dependent relationships resulting in a personal ecosystem...
April 25, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28444102/pet-mri-a-novel-hybrid-imaging-technique-major-clinical-indications-and-preliminary-experience-in-brazil
#8
Taise Vitor, Karine Minaif Martins, Tudor Mihai Ionescu, Marcelo Livorsi da Cunha, Ronaldo Hueb Baroni, Marcio Ricardo Taveira Garcia, Jairo Wagner, Guilherme de Carvalho Campos, Solange Amorim Nogueira, Elaine Gonçalves Guerra, Edson Amaro
In recent years, medical imaging with hybrid techniques has widely accepted and employed in clinical routine. PET/MRI offers significant advantages, including excellent contrast and resolution and reduced ionizing radiation, as compared to well-established PET/CT. Therefore, PET/MRI is a promising modality for oncologic imaging of some regions, such as brain, head and neck, liver and pelvis. This article set out to analyze clinical conditions that could benefit from PET/MRI imaging based on our caseload. The potential of PET/MRI to become the imaging modality of choice for assessment of neurologic and oncologic conditions associated with soft tissues is highlighted...
January 2017: Einstein
https://www.readbyqxmd.com/read/28443955/a-single-resistance-exercise-session-improves-aortic-endothelial-function-in-hypertensive-rats
#9
Thaís de Oliveira Faria, Jhuli Keli Angeli, Luiz Guilherme Marchesi Mello, Gustavo Costa Pinto, Ivanita Stefanon, Dalton Valentim Vassallo, Juliana Hott de Fúcio Lizardo
BACKGROUND: Physical exercise is an important tool for the improvement of endothelial function. OBJECTIVE: To assess the effects of acute dynamic resistance exercise on the endothelial function of spontaneously hypertensive rats (SHR). METHODS: Ten minutes after exercise, the aorta was removed to evaluate the expression of endothelial nitric oxide synthase (eNOS), phosphorylated endothelial nitric oxide synthase (p-eNOS1177) and inducible nitric oxide synthase (iNOS) and to generate concentration-response curves to acetylcholine (ACh) and to phenylephrine (PHE)...
March 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28442659/diagnostic-accuracy-of-endocardial-to-epicardial-myocardial-blood-flow-ratio-for-the-detection-of-significant-coronary-artery-disease-with-dynamic-myocardial-perfusion-dual-source-computed-tomography
#10
Yoshitaka Goto, Kakuya Kitagawa, Mio Uno, Shiro Nakamori, Tatsuro Ito, Naoki Nagasawa, Kaoru Dohi, Hajime Sakuma
BACKGROUND: Previous dynamic stress computed tomography perfusion (CTP) studies used absolute myocardial blood flow (MBF in mL/100 g/min) as a threshold to discriminate flow-limiting coronary artery disease (CAD), but absolute MBF can be vary because of multiple factors. The aim of this study was to compare the diagnostic performance of absolute MBF and the transmural perfusion ratio (TPR) for the detection of flow-limiting CAD, and to clarify the influence of CT delayed enhancement (CTDE) on the diagnostic performance of CTP...
April 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28441731/polyphenolic-compounds-and-digestive-enzymes-in-vitro-non-covalent-interactions
#11
REVIEW
Alejandra I Martinez-Gonzalez, Ángel G Díaz-Sánchez, Laura A de la Rosa, Claudia L Vargas-Requena, Ismael Bustos-Jaimes, And Emilio Alvarez-Parrilla
The digestive enzymes-polyphenolic compounds (PCs) interactions behind the inhibition of these enzymes have not been completely studied. The existing studies have mainly analyzed polyphenolic extracts and reported inhibition percentages of catalytic activities determined by UV-Vis spectroscopy techniques. Recently, pure PCs and new methods such as isothermal titration calorimetry and circular dichroism have been applied to describe these interactions. The present review focuses on PCs structural characteristics behind the inhibition of digestive enzymes, and progress of the used methods...
April 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28439221/congenital-hyperinsulinism-caused-by-a-de-novo-mutation-in-the-abcc8-gene-a-case-report
#12
Zsuzsanna Molnár, Lfdia Balogh, János Kappelmayer, László Madar, Éva Gombos, István Balogh
Congenital hyperinsulinism (CHI) is a rare genetic disorder characterized by inappropriate insulin secretion and severe hypoglycaemia. There are two histological subtypes: diffuse and focal form. Diffuse form is most common in autosomal recessive mutations in ABCC8/KCNJ11 gene, while focal CHI is caused a paternally inherited mutation and a somatic maternal allele loss. Here we report a case of a term male infant presented with severe hyperinsulinaemic hypoglycaemia. Gene panel testing was performed to give rapid genetic diagnosis...
March 2017: EJIFCC
https://www.readbyqxmd.com/read/28438895/the-casper-carotid-artery-stent-a-unique-all-metal-micromesh-stent-designed-to-prevent-embolic-release
#13
Orlando Diaz, Gloria Lopez, John O F Roehm, Ginna De la Rosa, Fernando Orozco, Rafael Almeida
BACKGROUND: Stroke due to the release of embolic debris during the placement of a stent to correct carotid artery stenosis is a constant procedural and peri-procedural threat. The new all metal Casper stent has been created with two layers of nitinol, the inner layer of which has pores diminutive enough to prevent embolic release. OBJECTIVE: To evaluate the safety, effectiveness, and utility of the double layer nitinol Casper carotid artery stent in the treatment of patients with severe carotid artery stenosis...
April 24, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28438519/role-of-18-f-fdg-pet-ct-in-primary-brain-lymphoma
#14
Á de-Bonilla-Damiá, R Fernández-López, F J Capote-Huelva, F de la Cruz-Vicente, J J Egea-Guerrero, I Borrego-Dorado
OBJECTIVE: To study the usefulness of (18)F-FDG PET/CT in the initial evaluation and in the response assessment in primary brain lymphoma. MATERIAL AND METHODS: A retrospective analysis was carried out on 18 patients diagnosed with primary brain lymphoma, a histological subtype of diffuse large B-cell lymphoma, on whom an initial (18)F-FDG PET/CT and MRI was performed, with 7 of the cases being analysed after the completion of treatment in order to assess response and clinical follow up...
April 21, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28438033/effects-of-polyphenol-removal-methods-on-the-in-vitro-exsheathment-inhibitory-activity-of-lysiloma-latisiliquum-extracts-against-haemonchus-contortus-larvae
#15
Gloria Ivonne Hernández-Bolio, Karlina García-Sosa, Fabiola Escalante-Erosa, Gloria Sarahi Castañeda-Ramírez, Enrique Sauri-Duch, Juan Felipe de Jesús Torres-Acosta, Luis Manuel Peña-Rodríguez
It has been suggested that the anthelmintic (AH) activity of tannin-rich forages is related to their tannin content. However, reports on tropical fodders such as Lysiloma latisiliquum describe the same AH activity after the addition of tannin-blocking agents, suggesting that the activity either depends on the method of tannin blocking/removal or is due to other type of secondary metabolites. This study compared both the effect of the drying process of the plant material and the effect of different polyphenol removal methods on the AH activity of L...
April 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28437679/nodal-recurrence-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-incidence-and-proposed-risk-factors
#16
REVIEW
Krista C J Wink, Angela van Baardwijk, Esther G C Troost, Dirk De Ruysscher
Stereotactic body radiotherapy (SBRT) is an alternative to surgery for patients with early stage non-small cell lung cancer (NSCLC) who are inoperable due to comorbid disease or who refuse surgery. SBRT results in an excellent local control rate of more than 90%, which is comparable to surgery, while short and long-term overall toxicity is low. Surgically treated patients are often more extensively staged pre-operatively, e.g. with endobronchial ultrasound and/or mediastinoscopy, and typically undergo intra-operative lymph node dissection or sampling...
April 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28434798/prognostic-value-of-dynamic-hypoxia-pet-in-head-and-neck-cancer-results-from-a-planned-interim-analysis-of-a-randomized-phase-ii-hypoxia-image-guided-dose-escalation-trial
#17
Stefan Welz, David Mönnich, Christina Pfannenberg, Konstantin Nikolaou, Mathias Reimold, Christian La Fougère, Gerald Reischl, Paul-Stefan Mauz, Frank Paulsen, Markus Alber, Claus Belka, Daniel Zips, Daniela Thorwarth
BACKGROUND AND PURPOSE: To prospectively assess the prognostic value of tumour hypoxia determined by dynamic [(18)F]Fluoromisonidazole (dynFMISO) PET/CT, and to evaluate both feasibility and toxicity in patients with locally advanced squamous cell carcinomas of the head and neck (LASCCHN) treated with dynFMISO image-guided dose escalation (DE) using dose-painting by contours. PATIENTS AND METHODS: We present a planned interim analysis of a randomized phase II trial...
April 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28434797/patterns-of-care-survey-radiotherapy-for-women-with-locally-advanced-cervical-cancer
#18
Peter de Boer, Ina M Jürgenliemk-Schulz, Henrike Westerveld, Astrid A C de Leeuw, Raquel Dávila-Fajardo, Coen R N Rasch, Bradley R Pieters, Lukas J A Stalpers
BACKGROUND AND PURPOSE: Regarding latest developments, the need of a radiotherapy 'Patterns of Care' survey was expressed by the Dutch National Platform Radiotherapy for Gynaecological Cancer (LPRGT). Therefore, this study investigated current practice for cervical cancer in all 16 radiation oncology centres in the Netherlands specialised in gynaecological oncology. MATERIAL AND METHODS: A structured 'patterns of care' questionnaire was completed and followed by an in-depth interview with radiation oncologists from all radiotherapy centres specialised in gynaecological oncology...
April 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28424870/high-intensity-interval-training-does-not-impair-strength-gains-in-response-to-resistance-training-in-premenopausal-women
#19
Paulo Gentil, Claudio Andre Barbosa de Lira, Suedi Gonçalves Cardoso Filho, Cauê Vazquez La Scala Teixeira, James Steele, James Fisher, Juliana Alves Carneiro, Mário Hebling Campos
PURPOSE: To compare the increases in upper- and lower-body muscle strength in premenopausal women performing resistance training (RT) alone or alongside concurrent high-intensity interval training (CT). METHODS: Sixteen women (26-40 years) were randomly assigned into two groups that performed either RT or CT. Both groups performed the same RT program; however, CT performed additional high-intensity interval training (HIIT) on a bicycle ergometer before RT. The study lasted 8 weeks and the participants were tested for ten repetition maximum (10RM) load in elbow flexion (barbell biceps curl) and knee extension exercises pre- and post-intervention...
April 19, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28424361/computed-tomographic-findings-in-subjects-who-died-from-respiratory-disease-in-the-national-lung-screening-trial
#20
Esther Pompe, Pim A de Jong, David A Lynch, Nikolas Lessmann, Ivana Išgum, Bram van Ginneken, Jan-Willem J Lammers, Firdaus A A Mohamed Hoesein
We evaluated the prevalence of significant lung abnormalities on computed tomography (CT) in patients who died from a respiratory illness other than lung cancer in the National Lung Screening Trial (NLST).In this retrospective case-control study, NLST participants in the CT arm who died of respiratory illness other than lung cancer were matched for age, sex, pack-years and smoking status to a surviving control. A chest radiologist and a radiology resident blinded to the outcome independently scored baseline CT scans visually and qualitatively for the presence of emphysema, airway wall thickening and fibrotic lung disease...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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