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https://www.readbyqxmd.com/read/28098340/inhibitory-effect-of-blue-light-emitting-diode-on-migration-and-invasion-of-cancer-cells
#1
Phil-Sun Oh, Hyun-Soo Kim, Eun-Mi Kim, Hyosook Hwang, Hyang Hwa Ryu, SeokTae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong
The aim of this study was to determine the effects and molecular mechanism of blue light emitting diode (LED) in tumor cells. A migration and invasion assay for the metastatic behavior of mouse colon cancer CT-26 and human fibrosarcoma HT-1080 cells was performed. Cancer cell migration-related proteins were identified by obtaining a 2-dimensional gel electrophoresis (2-DE) in total cellular protein profile of blue LED-irradiated cancer cells, followed by matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) analysis of proteins...
January 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28097450/contemporary-thoughts-on-the-management-of-spigelian-hernia
#2
V Webber, C Low, R J E Skipworth, S Kumar, A C de Beaux, B Tulloh
BACKGROUND: Spigelian hernias are said to be a rare condition of the elderly population, usually arising below the arcuate line. Local experience has led us to challenge these commonly held beliefs. METHODS: Operations for Spigelian hernia from 2006-2016 were identified from the Edinburgh Lothian Surgical Audit computerised database and case notes were reviewed. RESULTS: One hundred and one patients underwent surgery for 107 Spigelian hernias in the 10-year period...
January 17, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28095387/mri-of-cerebellar-infarction
#3
Laurens J L De Cocker, Karl-Olof Lövblad, Jeroen Hendrikse
BACKGROUND: MRI is the imaging modality of choice for diagnosing brain infarction. Because of few or atypical clinical symptoms and a relatively low sensitivity of CT scans, many cerebellar infarctions may be detected only with MRI. With adequate recognition of cerebellar infarction on MRI and prompt initiation or optimisation of preventive therapeutic measures, more dramatic strokes may be avoided in selected cases. SUMMARY: We first briefly review the clinical presentation of cerebellar infarctions, followed by a short refresher on cerebellar anatomy and pathophysiological mechanisms of cerebellar infarcts...
January 18, 2017: European Neurology
https://www.readbyqxmd.com/read/28094088/usefulness-of-multiparametric-computerized-tomography-findings-in-the-differential-diagnosis-of-stroke-mimics-of-epileptic-origin-a-preliminary-study
#4
R López Ruiz, S Quintas, P Largo, M de Toledo, M T Carreras, A Gago-Veiga, R Manzanares, J Vivancos
OBJECTIVE: Thirty percent of the patients for whom code stroke is activated have stroke mimics, the most common being epilepsy. Our purpose was to evaluate the usefulness of multiparametric CT for differentiating between seizure-related symptoms and vascular events. MATERIAL AND METHODS: We conducted a retrospective observational study; data were gathered prospectively during one year. We studied multiparametric CT images of patients admitted following code stroke activation and finally diagnosed with epilepsy...
January 13, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28092118/incorporation-of-ct-based-measurements-of-trunk-anatomy-into-subject-specific-musculoskeletal-models-of-the-spine-influences-vertebral-loading-predictions
#5
Alexander G Bruno, Hossein Mokhtarzadeh, Brett T Allaire, Kelsey R Velie, M Clara De Paolis Kaluza, Dennis E Anderson, Mary L Bouxsein
We created subject-specific musculoskeletal models of the thoracolumbar spine by incorporating spine curvature and muscle morphology measurements from computed tomography (CT) scans to determine the degree to which vertebral compressive and shear loading estimates are sensitive to variations in trunk anatomy. We measured spine curvature and trunk muscle morphology using spine CT scans of 125 men, and then created four different thoracolumbar spine models for each person: 1) height and weight adjusted (Ht/Wt models); 2) height, weight and spine curvature adjusted (+C models); 3) height, weight and muscle morphology adjusted (+M models); and 4) height, weight, spine curvature, and muscle morphology adjusted (+CM models)...
January 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28089539/reperfusion-therapy-in-patients-with-acute-ischaemic-stroke-caused-by-cervical-artery-dissection
#6
L A Crespo Araico, R Vera Lechuga, A Cruz-Culebras, C Matute Lozano, A de Felipe Mimbrera, P Agüero Rabes, E Viedma Guiard, C Estévez Fraga, J Masjuan Vallejo
INTRODUCTION: Cervical artery dissection (CAD) is responsible for up to 20% of all ischaemic strokes in patients younger than 45. The benefits of acute-phase reperfusion therapy in these patients have yet to be confirmed. METHODS: We conducted a retrospective review of patients with CAD admitted to a comprehensive stroke centre between 2010 and 2015. We recorded baseline clinical characteristics, treatments, functional outcomes, and mortality. RESULTS: We identified 35 cases of CAD (23 carotid/12 vertebral); mean age was 43...
January 12, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28087394/hawkins-type-ii-talar-fracturewithsubtalar-dislocation%C3%A2-a-veryunusualcombination
#7
Romain Gérard, Nathalie Kerfant, Geoffroy Dubois de Mont Marin, Richard Stern, Mathieu Assal
We report the unusualcase of a 16-year-old young man whosustained a rare association of a Hawkins' type-II talar neck fracture with a completemedialsubtalar dislocation (Hawkins type-IIB) thatoccurred as anisolatedinjuryafter indirect trauma during a soccer game. Followingclosedreduction of the subtalar dislocation, standard radiographs and computedtomography (CT)demonstrated a comminuted fracture of the talus involving the base of the talar neck. Open reductionwasperformed and the fracture wasstabilizedby ORIF...
January 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28086986/radioiodine-sinus-uptake-related-to-mucosal-thickening-or-aspergilloma-a-case-series-of-an-unrecognized-event-well-evidenced-by-spect-ct
#8
Renaud Ciappuccini, David Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Emmanuel Babin, Stéphane Bardet
BACKGROUND: False-positive radioiodine (RAI) uptake related to chronic sinusitis and mucocele has only rarely been reported in patients with differentiated thyroid cancer (DTC) even with the recent use of single photon emission tomography with computed tomography (SPECT/CT) acquisition. No other etiology of sinus RAI uptake has been mentioned to date. OBJECTIVES: We report five cases of DTC patients with sinus RAI uptake on post-RAI scintigraphy. SPECT/CT clearly localized RAI uptake either in the sphenoid, the maxillary or the frontal sinus and highly suspected mucosal thickening in four patients and sinus aspergilloma in one patient...
January 13, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28081050/white-paper-of-the-society-of-computed-body-tomography-and-magnetic-resonance-on-dual-energy-ct-part-3-vascular-cardiac-pulmonary-and-musculoskeletal-applications
#9
Carlo N De Cecco, U Joseph Schoepf, Lynne Steinbach, Daniel T Boll, W Dennis Foley, Ravi K Kaza, David N Bolus, Desiree E Morgan, Dushyant V Sahani, William P Shuman, Marilyn J Siegel, Terri J Vrtiska, Benjamin M Yeh, Lincoln L Berland
This is the third of a series of 4 white papers that represent Expert Consensus Documents developed by the Society of Computed Body Tomography and Magnetic Resonance through its Task Force on dual-energy computed tomography. This paper, part 3, describes computed tomography angiography and thoracic, cardiac, vascular, and musculoskeletal clinical applications. At the end of the discussion of each application category (vascular, cardiac, pulmonary, and musculoskeletal), we present our consensus opinions on the current clinical utility of the application and opportunities for further research...
January 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28079960/successful-medical-management-of-a-domestic-longhair-cat-with-subdural-intracranial-empyema-and-multifocal-pneumonia
#10
Thomas J A Cardy, Richard Lam, Laureen M Peters, Philippa J McLaren, Màrian Matas Riera, Steven De Decker
OBJECTIVE: To describe a case of successful medical management of subdural intracranial empyema and multifocal pneumonia in a domestic longhaired cat. CASE SUMMARY: A 7-year-and-8-month-old male neutered domestic longhair cat presented with tachypnea, respiratory compromise, vestibular ataxia, obtundation, left-sided head tilt, and multiple cranial nerve deficits. Neuroanatomical localization was multifocal with central vestibular involvement. Magnetic resonance imaging of the head indicated diffuse subdural empyema, mainly affecting the middle cranial fossa and the right cerebrum...
January 12, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28078522/long-term-impact-of-reduced-tillage-on-water-and-pesticide-flow-in-a-drained-context
#11
R Dairon, A Dutertre, J Tournebize, J Marks-Perreau, N Carluer
Influence of more than 20 years (1988-2010) of reduced tillage (RT) practices on water and pesticide balances and dynamics is analyzed and compared to results from a conventional tillage plot (CT). The field study soils are described as silty clay stagnic luvisol, developed on a low permeable schist layer. A drainage network was set up according to French criteria (0.9 m deep, 10 m space) to avoid soil winter waterlogging. Climate is temperate oceanic and drainage generally occurs from November to March...
January 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28076494/accuracy-of-mandibular-measurements-of-sexual-dimorphism-using-stabilizer-equipment
#12
Thais Torralbo Lopez, Edgard Michel-Crosato, Eduardo de Novaes Benedicto, Luiz Airton Saavedra de Paiva, Diogo Cesar Borges Silva, Maria Gabriela Haye Biazevic
The objective of this investigation was to compare the accuracy of mandibular measurements using a stabilizer (MS) with gold standard computed tomography (GS) images. Sixty mandibles were studied. Werth TomoScope HV Compact® was used to obtain CT images (GS), and the MS was also used. Analysis of the CT scans was performed using the VG Studio Max software® (Volume Graphics GmbH, Heidelberg, Germany), and MS was used after the proper positioning of the mandible. Descriptive and paired t test measures were used, and a ROC curve was calculated, as well as sensibility and specificity...
January 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28076479/dietary-management-for-dyslipidemia-in-liver-transplant-recipients
#13
Andressa S Pinto, Marcio F Chedid, Léa T Guerra, Daiane D Cabeleira, Cleber D P Kruel
Background: Dyslipidemia occurs in approximately 70% of all liver transplant (LT) recipients, and no prior control studies have demonstrated any dietary intervention to change it. Aim: To analyze the effects of a dietary intervention on the lipid profile of dyslipidemic LT recipients. Methods: All LT recipients with dyslipidemia on clinical follow-up were enrolled. Anthropometric evaluation, food history, body composition (bioimpedance) and assessment of basal metabolism through indirect calorimetry were performed...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28076472/evaluation-of-lymphatic-spread-visceral-metastasis-and-tumoral-local-invasion-in-esophageal-carcinomas
#14
Francisco Tustumi, Cintia Mayumi Sakurai Kimura, Flavio Roberto Takeda, Rubens Antônio Aissar Sallum, Ulysses Ribeiro-Junior, Ivan Cecconello
Background: Knowing esophageal tumors behavior in relationship to lymph node involvement, distant metastases and local tumor invasion is of paramount importance for the best esophageal tumors management. Aim: To describe lymph node involvement, distant metastases, and local tumor invasion in esophageal carcinoma, according to tumor topography and histology. Methods: A total of 444 patients with esophageal squamous cell carcinoma and 105 adenocarcinoma were retrospectively analyzed...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28075606/potential-application-of-dual-energy-ct-in-gynecologic-cancer-initial-experience
#15
Ana Paula Benveniste, Silvana de Castro Faria, Gregory Broering, Dhakshina Moorthy Ganeshan, Eric P Tamm, Revathy B Iyer, Priya Bhosale
OBJECTIVE: The purpose of this article is to review the use of dual-energy CT (DECT) in the assessment of gynecologic cancer. CONCLUSION: DECT has the potential to improve diagnostic performance, may improve the ability to differentiate between simple cystic lesions and primary ovarian cancer, and may also improve the detection of musculoskeletal and liver metastases. Additional studies will be needed to determine the direction of future developments and the degree to which DECT will affect the imaging and management of gynecologic cancer...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28073264/metal-organic-polyhedra-coated-si-nanowires-for-the-sensitive-detection-of-trace-explosives
#16
Anping Cao, Wei Zhu, Jin Shang, Johan H Klootwijk, Ernst J R Sudhölter, Jurriaan Huskens, Louis C P M de Smet
Surface-modified silicon nanowire-based field-effect transistors (SiNW-FETs) have proven to be a promising platform for molecular recognition in miniature sensors. In this work, we present a novel nanoFET device for the sensitive and selective detection of explosives based on affinity layers of metal-organic polyhedra (MOPs). The judicious selection of the geometric and electronic characteristics of the assembly units (organic ligands and unsaturated metal site) embedded within the MOP cage allowed for the formation of multiple charge-transfer (CT) interactions to facilitate the selective explosive inclusion...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28072578/mathematical-modelling-of-scanner-specific-bowtie-filters-for-monte-carlo-ct-dosimetry
#17
R Kramer, V F Cassola, M E A Andrade, M W C de Araújo, D J Brenner, H J Khoury
The purpose of bowtie filters in CT scanners is to homogenize the x-ray intensity measured by the detectors in order to improve the image quality and at the same time to reduce the dose to the patient because of the preferential filtering near the periphery of the fan beam. For CT dosimetry, especially for Monte Carlo calculations of organ and tissue absorbed doses to patients, it is important to take the effect of bowtie filters into account. However, material composition and dimensions of these filters are proprietary...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28070843/noise-optimized-monoenergetic-post-processing-improves-visualization-of-incidental-pulmonary-embolism-in-cancer-patients-undergoing-single-pass-dual-energy-computed-tomography
#18
Jakob Weiss, Mike Notohamiprodjo, Malte Bongers, Christoph Schabel, Stefanie Mangold, Konstantin Nikolaou, Fabian Bamberg, Ahmed E Othman
PURPOSE: To evaluate noise-optimized monoenergetic postprocessing of dual-energy CT (DE-CT) on image quality in patients with incidental pulmonary embolism in single-pass portal-venous phase CT (CTpv). MATERIALS AND METHODS: 20 Consecutive patients with incidental pulmonary embolism in contrast-enhanced oncological follow-up DE-CTpv examination were included in this study. Images were acquired with a 3rd generation DE-CT system in DE mode (100/Sn150 kV) and activated tube current modulation 90 s after contrast agent administration...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28070733/glp-1-ra-treatment-patterns-among-type-2-diabetes-patients-in-five-european-countries
#19
Victoria Divino, Mitch DeKoven, Farhad Ali Khan, Kristina S Boye, Hélène Sapin, Kirsi Norrbacka
INTRODUCTION: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a relatively new class of injectable drugs used in the treatment of type 2 diabetes (T2D). This retrospective database study evaluated real-world treatment patterns of T2D patients initiating GLP-1 RAs in Belgium (BE), France (FR), Germany (DE), The Netherlands (NL) and Sweden (SE). METHODS: Adult T2D patients initiating exenatide twice daily (exBID), exenatide once weekly (exQW), liraglutide (LIRA) or lixisenatide (LIXI) during 2013 were identified using the QuintilesIMS (QuintilesIMS, Durham, NC, and Danbury, CT, USA) longitudinal retail pharmacy databases (LRx; BE/FR/DE/NL) and national health register data (SE)...
January 9, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28070200/the-risk-of-hepatocellular-carcinoma-after-directly-acting-antivirals-for-hepatitis-c-virus-treatment-in-liver-transplanted-patients-is-it-real
#20
Alessio Strazzulla, Rosa Maria Rita Iemmolo, Ennio Carbone, Maria Concetta Postorino, Maria Mazzitelli, Mario De Santis, Fabrizio Di Benedetto, Costanza Maria Cristiani, Chiara Costa, Vincenzo Pisani, Carlo Torti
INTRODUCTION: Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after successful treatment with DAAs, along with a short review of literature. CASE PRESENTATION: In 2010, a 53-year old man, affected by chronic HCV (genotype 1) infection and decompensated cirrhosis, underwent liver resection for HCC and subsequently received orthotopic liver transplantation...
November 2016: Hepatitis Monthly
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