Ana C C Pereira, Alana P S Aguiar, Vinícius L Barbosa, Júlia R Régia, Erica Mina Miyazima, Leticia M P Araujo, Larissa O Dantas, Marcia P A Mayer, Flaviana B Andrade, Lamprini Karygianni, Ericka T Pinheiro
INTRODUCTION: Various strategies have been researched to enhance the susceptibility of biofilms, given their tolerance to antibiotics. This study evaluated the effect of the antimicrobial peptide nisin in association with antibiotics used in regenerative endodontics, exploring different treatment times and biofilm growth conditions. METHODS: A mixture of ten bacterial species was cultivated on dentin specimens anaerobically for 21 days. Biofilms were treated with 1 mL of high-purity nisin Z (nisin ZP, 200 μg/mL) and a triple antibiotic mixture (TAP: ciprofloxacin + metronidazole + minocycline, 5mg/ mL), alone or in combination...
April 12, 2024: Journal of Endodontics