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Vascular catheters colonization

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https://www.readbyqxmd.com/read/27663229/co-release-of-dicloxacillin-and-thioridazine-from-catheter-material-containing-an-interpenetrating-polymer-network-for-inhibiting-device-associated-staphylococcus-aureus-infection
#1
Michael Stenger, Kasper Klein, Rasmus B Grønnemose, Janne K Klitgaard, Hans J Kolmos, Jes S Lindholt, Martin Alm, Peter Thomsen, Thomas E Andersen
Approximately half of all nosocomial bloodstream infections are caused by bacterial colonization of vascular catheters. Attempts have been made to improve devices using anti-adhesive or antimicrobial coatings; however, it is often difficult to bind coatings stably to catheter materials, and the low amounts of drug in thin-film coatings limit effective long-term release. Interpenetrating polymer networks (IPNs) are polymer hybrid materials with unique drug release properties. While IPNs have been extensively investigated for use in tablet- or capsule-based drug delivery systems, the potential for use of IPNs in drug release medical devices remains largely unexplored...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27630843/microbiology-of-non-tunnelled-catheter-related-infections
#2
Shefali Gupta, Shrikara P Mallya, Ashok Bhat, Shrikala Baliga
INTRODUCTION: Aerobic bacterial infections often complicate vascular access in patients receiving haemodialysis, leading to Catheter-Related Blood Stream Infections (CRBSI). Various studies report Gram - positive bacteria, Staphylococcus aureus (S. aureus) in particular, as the most common aetiologic agent. Studies on microbiological analysis in this subset of population from India are very few. AIM: To examine clinical and bacteriological profiles of haemodialysis patients developing CRBSI, the antibiotic susceptibility of the bacteria isolated from these patients and determine nasal carriage of S...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27473868/guidewire-exchange-vs-new-site-placement-for-temporary-dialysis-catheter-insertion-in-icu-patients-is-there-a-greater-risk-of-colonization-or-dysfunction
#3
Elisabeth Coupez, Jean-François Timsit, Stéphane Ruckly, Carole Schwebel, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Julien Bohe, Maïté Garrouste-Orgeas, Christophe Mariat, François Vincent, Sophie Cayot, Olivier Cointault, Alain Lepape, Michael Darmon, Alexandre Boyer, Elie Azoulay, Lila Bouadma, Alexandre Lautrette, Bertrand Souweine
BACKGROUND: Intensive care unit (ICU) patients require dialysis catheters (DCs) for renal replacement therapy (RRT). They carry a high risk of developing end-stage renal disease, and therefore their vascular access must be preserved. Guidewire exchange (GWE) is often used to avoid venipuncture insertion (VPI) at a new site. However, the impact of GWE on infection and dysfunction of DCs in the ICU is unknown. Our aim was to compare the effect of GWE and VPI on DC colonization and dysfunction in ICU patients...
July 30, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27358213/extranasal-staphylococcus-aureus-colonization-predisposes-to-bloodstream-infections-in-patients-on-hemodialysis-with-noncuffed-internal-jugular-vein%C3%A2-catheters
#4
Anand Devraj, Venkata Siva Tez Pinnamaneni, Manisha Biswal, Raja Ramachandran, Vivekanand Jha
Introduction Staphylococcal infection of endogenous origin is an important cause of morbidity and mortality in patients who receive hemodialysis (HD). The risk of such infections in nasal carriers of the organism is well defined. Extranasal carriage of the organism at extranasal sites may pose similar risks. Methods A total of 70 patients about to undergo internal jugular vein catheterization for HD were enrolled in this prospective observational study. Swab cultures were obtained from anterior nares, posterior pharynx, axillae, toe web spaces, and vascular access sites at baseline and 1 week later...
June 29, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27354011/use-of-maldi-tof-to-detect-colonized-vascular-catheter-tips-after-6-and-12h-of-incubation
#5
Emilio Bouza, Raquel Cruces, María Jesús Pérez Granda, Belén Rodríguez-Sánchez, Pablo Martín-Rabadán, María Guembe
We analyzed by MALDI-TOF MS 80 catheter tips after 6h and 12h of incubation and the sensitivity of each incubation period for the identification of colonization and C-RBSI was, respectively, 9.5%-NA and 42.9%-28.6%. Despite MALDI-TOF MS cannot be used to predict catheter colonization, it may rule out C-RBSI.
September 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27234944/vascular-catheter-colonization-surveillance-based-on-culture-of-needleless-connectors
#6
María Jesús Pérez-Granda, María Guembe, Raquel Cruces, Emilio Bouza
BACKGROUND: Superficial culture has a high negative predictive value in the assessment of catheter tip colonization (CC) and catheter-related bloodstream infection (C-RBSI). However, the process of hub culture requires the hubs to be swabbed, and this carries a risk of dislodging the biofilm. At present, most catheter hubs are closed by needleless connectors (NCs) that are periodically replaced. Our objective was to compare the yield of SC (skin + hub culture) with that of skin + NC culture in the assessment of CC and C-RBSI...
2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27104605/infection-risk-reduction-in-the-intensive-care-nursery-a-review-of-patient-care-practices-that-impact-the-infection-risk-in-global-care-of-the-hospitalized-neonates
#7
Linda Lefrak
Neonates are at high risk for developing an infection during their hospital stay in the neonatal intensive care unit. Increased risk occurs because of immaturity of the neonate's immune system, lower gestational age, severity of illness, surgical procedures, and instrumentation with life support devices such as vascular catheters. Neonates become colonized with bacteria prior to or at delivery and also during their hospital stay. They can then become infected with those bacteria if there is a breakdown in the primary defenses such as tissue injury due to skin breakdown, nasal erosion, or trauma to the respiratory tract...
April 2016: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/26362005/central-venous-catheter-repair-is-not-associated-with-an-increased-risk-of-central-line-infection-or-colonization-in-intestinal-failure-pediatric-patients
#8
Claire McNiven, Noah Switzer, Melisssa Wood, Rabin Persad, Marie Hancock, Sarah Forgie, Bryan J Dicken
PURPOSE: The intestinal failure (IF) population is dependent upon central venous catheters (CVC) to maintain minimal energy requirements for growth. Central venous catheter infections (CVCI) are frequent and an independent predictor of intestinal failure associated liver disease. A common complication in children with long-term CVC is the risk of line breakage. Given the often-limited usable vascular access sites in this population, it has been the standard of practice to perform repair of the broken line...
March 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26290400/epidemiology-of-methicillin-susceptible-staphylococcus-aureus-in-a-neonatology-ward
#9
Yvonne Achermann, Kati Seidl, Stefan P Kuster, Nadja Leimer, Nina Durisch, Evelyne Ajdler-Schäffler, Stephan Karrer, Gabriela Senn, Anne Holzmann-Bürgel, Aline Wolfensberger, Antonio Leone, Romaine Arlettaz, Annelies S Zinkernagel, Hugo Sax
OBJECTIVE: In-hospital transmission of methicillin-susceptible Staphylococcus aureus (MSSA) among neonates remains enigmatic. We describe the epidemiology of MSSA colonization and infection in a 30-bed neonatal ward. DESIGN: Multimodal outbreak investigation SETTING: A public 800-bed tertiary care university hospital in Switzerland METHODS: Investigations in 2012-2013, triggered by a MSSA infection cluster, included prospective MSSA infection surveillance, microbiologic screening of neonates and environment, onsite observations, and a prospective cohort study...
November 2015: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/25854306/clinical-significance-of-candida-colonization-of-central-vascular-catheters-in-patients-with-major-burns-requiring-intensive-care
#10
LETTER
Alexandra Fochtmann, Christina Forstner, Maike Keck, Gabriela Muschitz, Elisabeth Presterl, Gerald Ihra, Thomas Rath
No abstract text is available yet for this article.
June 2015: Intensive Care Medicine
https://www.readbyqxmd.com/read/25852825/an-engineered-micropattern-to-reduce-bacterial-colonization-platelet-adhesion-and-fibrin-sheath-formation-for-improved-biocompatibility-of-central-venous-catheters
#11
Rhea M May, Chelsea M Magin, Ethan E Mann, Michael C Drinker, John C Fraser, Christopher A Siedlecki, Anthony B Brennan, Shravanthi T Reddy
BACKGROUND: Catheter-related bloodstream infections (CRBSIs) and catheter-related thrombosis (CRT) are common complications of central venous catheters (CVC), which are used to monitor patient health and deliver medications. CVCs are subject to protein adsorption and platelet adhesion as well as colonization by the natural skin flora (i.e. Staphylococcus aureus and Staphylococcus epidermidis). Antimicrobial and antithrombotic drugs can prevent infections and thrombosis-related complications, but have associated resistance and safety risks...
2015: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/25442921/-catheterization-and-fungal-infection-risk-in-the-university-hospital-of-tlemcen-epidemiology-and-susceptibility-to-antifungals
#12
A Seghir, Z Boucherit-Otmani, L Belkherroubi-Sari, K Boucherit
Fungal infections are a major cause of morbidity and mortality, and are frequently associated with the implantation of vascular catheters, especially in immune-compromised patients. Unfortunately, the therapeutic arsenal available for the treatment of these infections, caused generally by the yeasts of the genus Candida is still limited because of the toxicity and/or of the emergence of resistance against some antifungal agents. That is why we have undertaken this study, which is to determine the incidence and the degree of sensitivity of Candida spp...
December 2014: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/25404862/pulsative-flushing-as-a-strategy-to-prevent-bacterial-colonization-of-vascular-access-devices
#13
Agnès Ferroni, Florian Gaudin, Gérard Guiffant, Patrice Flaud, Jean-Jacques Durussel, Philippe Descamps, Patrick Berche, Xavier Nassif, Jacques Merckx
Central venous device infections are associated with increased physical and psychological morbidity, mortality, length of stay, and costs. The aim of this study was to prove the efficacy of pulsatile flushing to prevent the bacterial colonization of vascular access devices. One hundred and forty four tests using 576 polyurethane short venous access catheters were performed. Four catheters per test were polluted with a fibronectin-serum albumin solution. Three were filled with a Staphylococcus aureus broth; one served as negative control...
2014: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/24882583/initial-and-extended-use-of-femoral-versus-nonfemoral-double-lumen-vascular-catheters-and-catheter-related-infection-during-continuous-renal-replacement-therapy
#14
COMPARATIVE STUDY
Horng-Ruey Chua, Antoine G Schneider, Norelle L Sherry, Nadiah Lotfy, Matthew J Chan, Jonathan Galtieri, Geoffrey R Wong, Miklos Lipcsey, Cauê de Araujo Matte, Allison Collins, Mercedes Garcia-Alvarez, Rinaldo Bellomo
BACKGROUND: The risk of catheter-related infection or bacteremia, with initial and extended use of femoral versus nonfemoral sites for double-lumen vascular catheters (DLVCs) during continuous renal replacement therapy (CRRT), is unclear. STUDY DESIGN: Retrospective observational cohort study. SETTING & PARTICIPANTS: Critically ill patients on CRRT in a combined intensive care unit of a tertiary institution. FACTOR: Femoral versus nonfemoral venous DLVC placement...
December 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/24828604/cross-sensitization-mechanisms-between-colon-and-bladder-via-transient-receptor-potential-a1-stimulation-in-rats
#15
Akira Furuta, Yasuyuki Suzuki, Takehito Naruoka, Kouji Asano, Shin Egawa, Naoki Yoshimura
INTRODUCTION AND HYPOTHESIS: The aim of this study was to analyze the mechanism underlying cross-sensitization between the colon and the bladder via activation of transient receptor potential A1 (TRPA1) channels. METHODS: Using female Sprague-Dawley rats, polyethylene catheters were inserted into the colon between two ligations at the levels of 40 and 60 mm rostral to the anus and into the bladder. (1) We examined changes in colon and bladder activity after the application of allyl isothiocyanate (AI, 50 mM, 300 μl), a TRPA1 activator, into the colon or the bladder in an awake condition...
November 2014: International Urogynecology Journal
https://www.readbyqxmd.com/read/24756387/evaluation-of-correlations-between-underlying-disease-and-port-complications
#16
U Teichgräber, S N Nagel, S Kausche
PURPOSE: Evaluation of correlations between underlying disease and port complications. MATERIALS AND METHODS: Retrospective analysis of a data set of 3160 port systems, which had been interventionally implanted over a period of 10 years. Of these, 1393 were included in the final evaluation. The 7 most common underlying diseases and port-induced complications were considered. Port-related thrombotic events, port pocket infections as well as the port-induced sepsis were evaluated and classified as either early or late complications...
May 2014: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/24745908/electrically-conductive-catheter-inhibits-bacterial-colonization
#17
Hayet Amalou, Ayele H Negussie, Ashish Ranjan, Lucy Chow, Sheng Xu, Craig Kroeger, Ziv Neeman, Naomi P O'Grady, Bradford J Wood
PURPOSE: To design, prototype, and assess a custom vascular access catheter for its ability to inhibit bacterial colonization in vitro and to optimize electric parameters for efficacy and safe translation. MATERIALS AND METHODS: A vascular access catheter with conductive elements was designed and custom fabricated with two electrodes at the tip, separated by a nonconductive segment. The catheter was colonized with Staphylococcus aureus and incubated at predetermined current levels (4-8 µA) and durations (4-24 h)...
May 2014: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/24725023/septic-transfusion-reactions-during-blood-transfusion-via-indwelling-central-venous-catheters
#18
Kristin S Ricci, Fernando Martinez, Benjamin Lichtiger, Xiang Y Han
BACKGROUND: Transfusion of blood products requires a vascular port. Use of an indwelling central venous catheter (CVC) provides this port readily and safely in general; however, potential risks require assessment. STUDY DESIGN AND METHODS: The objective was to examine septic reactions to blood transfusions performed via CVCs owing to subclinical microbial catheter colonization. All transfusion reactions that occurred from 2007 to 2011 at The University of Texas MD Anderson Cancer Center were analyzed and correlated with microbiology culture results...
October 2014: Transfusion
https://www.readbyqxmd.com/read/24569952/heparin-bonded-catheters-for-prolonging-the-patency-of-central-venous-catheters-in-children
#19
REVIEW
Prakeshkumar S Shah, Niketa Shah
BACKGROUND: Central venous catheters (CVCs) are a mainstay in the management of critically ill children. However, these catheters are associated with mechanical and infectious complications which reduce their life span. Heparin bonding of catheters has shown promise in animal studies and in adults. This is the first update of a review published in 2007. OBJECTIVES: The primary objective was to determine the effect of heparin-bonded CVCs on the duration of catheter patency in children...
February 25, 2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24534639/transealing-a-novel-and-simple-technique-for-embolization-of-type-2-endoleaks-through-direct-sac-access-from-the-distal-stent-graft-landing-zone
#20
G Coppi, G Saitta, G Coppi, S Gennai, A Lauricella, R Silingardi
OBJECTIVE: Type 2 endoleak (T2EL) is the Achilles' heel of endovascular abdominal aortic aneurysm repair. Experience with transealing, an alternative technique for the treatment of T2ELs, is described. METHODS: The outcome of a group of patients treated with transealing has been reviewed. Femoral access was obtained with a 9-Fr sheath. A super-stiff guide wire and a stiff hydrophilic wire were placed inside the stent-graft and a Piton GC catheter inserted. The stiff hydrophilic wire was retrieved to allow the catheter to regain its curvature and the catheter tip was placed against the iliac wall, at the edge of the stent-graft...
April 2014: European Journal of Vascular and Endovascular Surgery
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