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Vascular catheters colonization

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https://www.readbyqxmd.com/read/28873268/a-novel-in-vitro-model-for-hematogenous-spreading-of-s-aureus-device-biofilms-demonstrating-clumping-dispersal-as-an-advantageous-dissemination-mechanism
#1
R B Grønnemose, K L Saederup, H J Kolmos, S W K Hansen, C A Asferg, K J Rasmussen, Y Palarasah, T E Andersen
Staphylococcus aureus is able to disseminate from vascular device biofilms to the blood and organs, resulting in life-threatening infections such as endocarditis. The mechanisms behind spreading are largely unknown, especially how the bacterium escapes immune effectors and antibiotics in the process. Using an in vitro catheter infection model, we studied S. aureus biofilm growth, late-stage dispersal, and reattachment to downstream endothelial cell layers. The ability of the released biofilm material to resist host response and disseminate in vivo was furthermore studied in whole blood- and phagocyte survival assays, and in a short-term murine infection model...
September 5, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28675244/a-catheter-related-bloodstream-infection-caused-by-chryseobacterium-indologenes-successfully-treated-with-antibiotic-lock-rescue-therapy
#2
Marta Corbella, Micaela Brandolini, Patrizia Cambieri, Nunzia Decembrino, Michele Pagani, Andrea Bottazzi, Alba Muzzi, Marco Zecca, Bianca Mariani, Piero Marone
We report the case of a catheter-related bloodstream infection caused by Chryseobacterium indologenes, an uncommon and multi-resistant pathogen, in a pediatric patient with a long-term vascular access device placed for chemotherapy treatment. The infection was successfully treated with ciprofloxacin antibiotic-lock therapy. This is the first report on successful salvage of a long-term device colonized by multi-resistant Chryseobacterium indologenes.
July 4, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28638222/corticotropin-releasing-factor-stimulates-colonic-motility-via-muscarinic-receptors-in-the-rat
#3
Kyung-Jo Kim, Ki Bae Kim, Soon Man Yoon, Joung-Ho Han, Hee Bok Chae, Seon Mee Park, Sei Jin Youn
AIM: To measure exogenous corticotropin-releasing factor (CRF)-induced motility of the isolated rat colon and to demonstrate the effect of pharmacologic inhibition on CRF-induced motility. METHODS: The isolated vascularly-perfused rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers in the proximal and distal colon. At first, exogenous CRF was administered in a stepwise manner and the concentration of CRF yielding maximal colonic motility was selected...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28574141/totally-implantable-venous-access-devices-in-children-with-medical-complexity-preliminary-data-from-a-tertiary-care-hospital
#4
Caterina Geremia, Maria Antonietta De Ioris, Alessandro Crocoli, Ottavio Adorisio, Raffaella Scrocca, Mary Haywood Lombardi, Susanna Staccioli, Pietro Stella, Paola Amendola, Gaetano Ciliento, Francesco De Peppo, Andrea Campana
INTRODUCTION: Children with special health-care needs are an emerging and consistent population. In a subset of children with medical complexity (CMC) a continuous access to the central vascular system is advisable to eliminate unnecessary pain and stress and to improve home management and palliative care. METHODS: The surgical registry of a tertiary hospital was checked in order to identify CMC who underwent totally implantable venous access device (VAD) placement...
May 24, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28320713/in-vitro-study-of-antimicrobial-percutaneous-nephrostomy-catheters-for-prevention-of-renal-infections
#5
Nylev Vargas-Cruz, Ruth A Reitzel, Joel Rosenblatt, Mohamed Jamal, Ariel D Szvalb, Anne-Marie Chaftari, Ray Hachem, Issam Raad
Percutaneous nephrostomy (PCN) catheters are the primary method for draining ureters obstructed by malignancy and preventing a decline of renal function. However, PCN catheter-related infections, such as pyelonephritis and urosepsis, remain a significant concern. Currently, no antimicrobial PCN catheters are available for preventing infection complications. Vascular catheters impregnated with minocycline-rifampin (M/R) and M/R with chlorhexidine coating (M/R plus CHD) have previously demonstrated antimicrobial activity...
June 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28110054/slicing-silicone-neonatal-vascular-catheter-tips-improves-colonization-detection-by-the-roll-plate-technique
#6
M Guembe, P Martín-Rabadán, R Cruces, M J Pérez Granda, E Bouza
OBJECTIVE: Silicone neonatal peripherally inserted central catheters (SN-PICCs) are a common cause of catheter-related bloodstream infection (C-RBSI) in neonates. Our objective was to compare the yield of traditional roll-plate technique (TRP), roll-plate after slicing (RPS), and sonication after slicing (SS) for the detection of colonization and C-RBSI in SN-PICCs. METHODS: We prospectively cultured tips from SN-PICCs withdrawn from paediatric patients admitted to our institution with suspicion of infection...
January 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27663229/co-release-of-dicloxacillin-and-thioridazine-from-catheter-material-containing-an-interpenetrating-polymer-network-for-inhibiting-device-associated-staphylococcus-aureus-infection
#7
Michael Stenger, Kasper Klein, Rasmus B Grønnemose, Janne K Klitgaard, Hans J Kolmos, Jes S Lindholt, Martin Alm, Peter Thomsen, Thomas E Andersen
Approximately half of all nosocomial bloodstream infections are caused by bacterial colonization of vascular catheters. Attempts have been made to improve devices using anti-adhesive or antimicrobial coatings; however, it is often difficult to bind coatings stably to catheter materials, and the low amounts of drug in thin-film coatings limit effective long-term release. Interpenetrating polymer networks (IPNs) are polymer hybrid materials with unique drug release properties. While IPNs have been extensively investigated for use in tablet- or capsule-based drug delivery systems, the potential for use of IPNs in drug release medical devices remains largely unexplored...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27630843/microbiology-of-non-tunnelled-catheter-related-infections
#8
Shefali Gupta, Shrikara P Mallya, Ashok Bhat, Shrikala Baliga
INTRODUCTION: Aerobic bacterial infections often complicate vascular access in patients receiving haemodialysis, leading to Catheter-Related Blood Stream Infections (CRBSI). Various studies report Gram - positive bacteria, Staphylococcus aureus (S. aureus) in particular, as the most common aetiologic agent. Studies on microbiological analysis in this subset of population from India are very few. AIM: To examine clinical and bacteriological profiles of haemodialysis patients developing CRBSI, the antibiotic susceptibility of the bacteria isolated from these patients and determine nasal carriage of S...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27473868/guidewire-exchange-vs-new-site-placement-for-temporary-dialysis-catheter-insertion-in-icu-patients-is-there-a-greater-risk-of-colonization-or-dysfunction
#9
Elisabeth Coupez, Jean-François Timsit, Stéphane Ruckly, Carole Schwebel, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Julien Bohe, Maïté Garrouste-Orgeas, Christophe Mariat, François Vincent, Sophie Cayot, Olivier Cointault, Alain Lepape, Michael Darmon, Alexandre Boyer, Elie Azoulay, Lila Bouadma, Alexandre Lautrette, Bertrand Souweine
BACKGROUND: Intensive care unit (ICU) patients require dialysis catheters (DCs) for renal replacement therapy (RRT). They carry a high risk of developing end-stage renal disease, and therefore their vascular access must be preserved. Guidewire exchange (GWE) is often used to avoid venipuncture insertion (VPI) at a new site. However, the impact of GWE on infection and dysfunction of DCs in the ICU is unknown. Our aim was to compare the effect of GWE and VPI on DC colonization and dysfunction in ICU patients...
July 30, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27358213/extranasal-staphylococcus-aureus-colonization-predisposes-to-bloodstream-infections-in-patients-on-hemodialysis-with-noncuffed-internal-jugular-vein%C3%A2-catheters
#10
Anand Devraj, Venkata Siva Tez Pinnamaneni, Manisha Biswal, Raja Ramachandran, Vivekanand Jha
INTRODUCTION:  Staphylococcal infection of endogenous origin is an important cause of morbidity and mortality in patients who receive hemodialysis (HD). The risk of such infections in nasal carriers of the organism is well defined. Extranasal carriage of the organism at extranasal sites may pose similar risks. METHODS:  A total of 70 patients about to undergo internal jugular vein catheterization for HD were enrolled in this prospective observational study. Swab cultures were obtained from anterior nares, posterior pharynx, axillae, toe web spaces, and vascular access sites at baseline and 1 week later...
January 2017: Hemodialysis International
https://www.readbyqxmd.com/read/27354011/use-of-maldi-tof-to-detect-colonized-vascular-catheter-tips-after-6-and-12h-of-incubation
#11
Emilio Bouza, Raquel Cruces, María Jesús Pérez Granda, Belén Rodríguez-Sánchez, Pablo Martín-Rabadán, María Guembe
We analyzed by MALDI-TOF MS 80 catheter tips after 6h and 12h of incubation and the sensitivity of each incubation period for the identification of colonization and C-RBSI was, respectively, 9.5%-NA and 42.9%-28.6%. Despite MALDI-TOF MS cannot be used to predict catheter colonization, it may rule out C-RBSI.
September 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27234944/vascular-catheter-colonization-surveillance-based-on-culture-of-needleless-connectors
#12
María Jesús Pérez-Granda, María Guembe, Raquel Cruces, Emilio Bouza
BACKGROUND: Superficial culture has a high negative predictive value in the assessment of catheter tip colonization (CC) and catheter-related bloodstream infection (C-RBSI). However, the process of hub culture requires the hubs to be swabbed, and this carries a risk of dislodging the biofilm. At present, most catheter hubs are closed by needleless connectors (NCs) that are periodically replaced. Our objective was to compare the yield of SC (skin + hub culture) with that of skin + NC culture in the assessment of CC and C-RBSI...
May 28, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27104605/infection-risk-reduction-in-the-intensive-care-nursery-a-review-of-patient-care-practices-that-impact-the-infection-risk-in-global-care-of-the-hospitalized-neonates
#13
Linda Lefrak
Neonates are at high risk for developing an infection during their hospital stay in the neonatal intensive care unit. Increased risk occurs because of immaturity of the neonate's immune system, lower gestational age, severity of illness, surgical procedures, and instrumentation with life support devices such as vascular catheters. Neonates become colonized with bacteria prior to or at delivery and also during their hospital stay. They can then become infected with those bacteria if there is a breakdown in the primary defenses such as tissue injury due to skin breakdown, nasal erosion, or trauma to the respiratory tract...
April 2016: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/26362005/central-venous-catheter-repair-is-not-associated-with-an-increased-risk-of-central-line-infection-or-colonization-in-intestinal-failure-pediatric-patients
#14
Claire McNiven, Noah Switzer, Melisssa Wood, Rabin Persad, Marie Hancock, Sarah Forgie, Bryan J Dicken
PURPOSE: The intestinal failure (IF) population is dependent upon central venous catheters (CVC) to maintain minimal energy requirements for growth. Central venous catheter infections (CVCI) are frequent and an independent predictor of intestinal failure associated liver disease. A common complication in children with long-term CVC is the risk of line breakage. Given the often-limited usable vascular access sites in this population, it has been the standard of practice to perform repair of the broken line...
March 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26290400/epidemiology-of-methicillin-susceptible-staphylococcus-aureus-in-a-neonatology-ward
#15
Yvonne Achermann, Kati Seidl, Stefan P Kuster, Nadja Leimer, Nina Durisch, Evelyne Ajdler-Schäffler, Stephan Karrer, Gabriela Senn, Anne Holzmann-Bürgel, Aline Wolfensberger, Antonio Leone, Romaine Arlettaz, Annelies S Zinkernagel, Hugo Sax
OBJECTIVE: In-hospital transmission of methicillin-susceptible Staphylococcus aureus (MSSA) among neonates remains enigmatic. We describe the epidemiology of MSSA colonization and infection in a 30-bed neonatal ward. DESIGN: Multimodal outbreak investigation SETTING: A public 800-bed tertiary care university hospital in Switzerland METHODS: Investigations in 2012-2013, triggered by a MSSA infection cluster, included prospective MSSA infection surveillance, microbiologic screening of neonates and environment, onsite observations, and a prospective cohort study...
November 2015: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/25854306/clinical-significance-of-candida-colonization-of-central-vascular-catheters-in-patients-with-major-burns-requiring-intensive-care
#16
LETTER
Alexandra Fochtmann, Christina Forstner, Maike Keck, Gabriela Muschitz, Elisabeth Presterl, Gerald Ihra, Thomas Rath
No abstract text is available yet for this article.
June 2015: Intensive Care Medicine
https://www.readbyqxmd.com/read/25852825/an-engineered-micropattern-to-reduce-bacterial-colonization-platelet-adhesion-and-fibrin-sheath-formation-for-improved-biocompatibility-of-central-venous-catheters
#17
Rhea M May, Chelsea M Magin, Ethan E Mann, Michael C Drinker, John C Fraser, Christopher A Siedlecki, Anthony B Brennan, Shravanthi T Reddy
BACKGROUND: Catheter-related bloodstream infections (CRBSIs) and catheter-related thrombosis (CRT) are common complications of central venous catheters (CVC), which are used to monitor patient health and deliver medications. CVCs are subject to protein adsorption and platelet adhesion as well as colonization by the natural skin flora (i.e. Staphylococcus aureus and Staphylococcus epidermidis). Antimicrobial and antithrombotic drugs can prevent infections and thrombosis-related complications, but have associated resistance and safety risks...
2015: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/25442921/-catheterization-and-fungal-infection-risk-in-the-university-hospital-of-tlemcen-epidemiology-and-susceptibility-to-antifungals
#18
A Seghir, Z Boucherit-Otmani, L Belkherroubi-Sari, K Boucherit
Fungal infections are a major cause of morbidity and mortality, and are frequently associated with the implantation of vascular catheters, especially in immune-compromised patients. Unfortunately, the therapeutic arsenal available for the treatment of these infections, caused generally by the yeasts of the genus Candida is still limited because of the toxicity and/or of the emergence of resistance against some antifungal agents. That is why we have undertaken this study, which is to determine the incidence and the degree of sensitivity of Candida spp...
December 2014: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/25404862/pulsative-flushing-as-a-strategy-to-prevent-bacterial-colonization-of-vascular-access-devices
#19
Agnès Ferroni, Florian Gaudin, Gérard Guiffant, Patrice Flaud, Jean-Jacques Durussel, Philippe Descamps, Patrick Berche, Xavier Nassif, Jacques Merckx
Central venous device infections are associated with increased physical and psychological morbidity, mortality, length of stay, and costs. The aim of this study was to prove the efficacy of pulsatile flushing to prevent the bacterial colonization of vascular access devices. One hundred and forty four tests using 576 polyurethane short venous access catheters were performed. Four catheters per test were polluted with a fibronectin-serum albumin solution. Three were filled with a Staphylococcus aureus broth; one served as negative control...
2014: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/24882583/initial-and-extended-use-of-femoral-versus-nonfemoral-double-lumen-vascular-catheters-and-catheter-related-infection-during-continuous-renal-replacement-therapy
#20
COMPARATIVE STUDY
Horng-Ruey Chua, Antoine G Schneider, Norelle L Sherry, Nadiah Lotfy, Matthew J Chan, Jonathan Galtieri, Geoffrey R Wong, Miklos Lipcsey, Cauê de Araujo Matte, Allison Collins, Mercedes Garcia-Alvarez, Rinaldo Bellomo
BACKGROUND: The risk of catheter-related infection or bacteremia, with initial and extended use of femoral versus nonfemoral sites for double-lumen vascular catheters (DLVCs) during continuous renal replacement therapy (CRRT), is unclear. STUDY DESIGN: Retrospective observational cohort study. SETTING & PARTICIPANTS: Critically ill patients on CRRT in a combined intensive care unit of a tertiary institution. FACTOR: Femoral versus nonfemoral venous DLVC placement...
December 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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