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https://www.readbyqxmd.com/read/29340213/non-coding-rnas-as-transcriptional-regulators-in-eukaryotes
#1
O Y Burenina, T S Oretskaya, E A Kubareva
Non-coding RNAs up to 1,000 nucleotides in length are widespread in eukaryotes and fulfil various regulatory functions, in particular during chromatin remodeling and cell proliferation. These RNAs are not translated into proteins: thus, they are non-coding RNAs (ncRNAs). The present review describes the eukaryotic ncRNAs involved in transcription regulation, first and foremost, targeting RNA polymerase II (RNAP II) and/or its major proteinaceous transcription factors. The current state of knowledge concerning the regulatory functions of SRA and TAR RNA, 7SK and U1 snRNA, GAS5 and DHFR RNA is summarized herein...
October 2017: Acta Naturae
https://www.readbyqxmd.com/read/29310950/expression-and-clinical-role-of-long-non-coding-rna-in-high-grade-serous-carcinoma
#2
Natalie Filippov-Levy, Hallel Cohen-Schussheim, Claes G Tropé, Thea E Hetland Falkenthal, Yoav Smith, Ben Davidson, Reuven Reich
OBJECTIVE: To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS: LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosomes from 30 effusion supernatants. Anatomic site-related expression of ESRG, Link-A, GAS5, MEG3, GATS, PVT1 H19, Linc-RoR, HOTAIR and MALAT1 was validated by quantitative PCR and assessed for clinical relevance in a series of 77 HGSC effusions, 40 ovarian carcinomas, 21 solid metastases and 42 supernatant exosomes...
January 5, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29296179/identification-and-validation-long-non-coding-rnas-of-oral-squamous-cell-carcinoma-by-bioinformatics-method
#3
Meng Yang, Xingliang Xiong, Longcong Chen, Li Yang, Xian Li
Gene markers of oral squamous cell carcinoma (OSCC) have great significance on early diagnosis and treatment of clinical oral cancer. In this study, we used RNA-Seq data from OSCC patients and filtered differentially-expressed long non-coding RNA (lncRNA) to further clarify the molecular mechanism. Firstly, we downloaded datasets of OSCC from National Center for Biotechnology Information(NCBI), which were predicted and analyzed by cufflinks and tophat. Then, differentially expressed lncRNA enrichment was performed with The Database for Annotation, Visualization and Integrated Discovery (DAVID)...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29249416/lncrna-gas5-as1-inhibits-myofibroblasts-activities-in-oral-submucous-fibrosis
#4
Che-Yi Lin, Yi-Wen Liao, Pei-Ling Hsieh, Ming-Yi Lu, Chih-Yu Peng, Pei-Ming Chu, Hui-Wen Yang, Yu-Feng Huang, Cheng-Chia Yu, Chuan-Hang Yu
BACKGROUND/PURPOSE: Emerging research findings suggest that long non-coding RNAs (lncRNAs) are key regulators to fibrosis formation. Nevertheless, the role of lncRNA GAS5-AS1 in the progression of precancerous oral submucous fibrosis (OSF) remains to be elucidated. METHODS: Quantitative real-time PCR were used to examine the expression of GAS5-AS1 in OSF tissues. The activities of myofibroblasts, including collagen contractility and cell migration, as well as the marker α-smooth muscle actin (SMA) were assessed following overexpression of GAS5-AS1...
December 14, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29232661/downregulation-of-long-noncoding-rna-gas5-affects-cell-cycle-and-insulin-secretion-in-mouse-pancreatic-%C3%AE-cells
#5
Feiyan Jin, Ning Wang, Yanan Zhu, Lianghui You, Lintao Wang, Wei De, Wei Tang
BACKGROUND: Evidence shows that long non-coding RNAs (lncRNAs) are involved in individual development, cell differentiation, cell cycle processes and other important life processes and are closely related to major human diseases, including diabetes. Recent studies have reported that lncRNAs are involved in β cell functions and that lncRNA Gas5 levels decreased in T2DM patients' serum. The purpose of this study was to clarify the role of lncRNA Gas5 in mouse β cell functions in vitro and in vivo...
October 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29229673/lncrna-gas5-suppresses-ovarian-cancer-by-inducing-inflammasome-formation
#6
Jie Li, Chen Yang, Yinguang Li, Aiyue Chen, Li Li, Zeshan You
OBJECTIVE: Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is involved in various kinds of cancer. However, the role of lncGAS5 in the development of ovarian cancer remains unclear. In the current study, we explored the cellular mechanism and clinical value of lncRNA GAS5 in ovarian cancer. METHODS: Quantitative real-time PCR was used to detect mRNA level of LncRNA GAS5 in 20 ovarian cancer tissues. The effect of lncRNA GAS5 on cell proliferation was performed using CCK-8 assay...
December 11, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29225772/long-non-coding-rna-gas5-suppresses-pancreatic-cancer-metastasis-through-modulating-mir-32-5p-pten-axis
#7
Zhi-Qiang Gao, Jun-Feng Wang, De-Hua Chen, Xue-Song Ma, Yang Wu, Zhe Tang, Xiao-Wei Dang
Background: Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. The precise role of GAS5 in pancreatic cancer (PC) progression is currently unknown, so the aim of this study was to explore the functional participation of GAS5 in PC metastasis. Methods: The expression changes of GAS5, miR-32-5p and PTEN in human PC specimens and cell lines were compared by means of molecular biology methods...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29207621/genetic-variation-of-lncrna-gas5-contributes-to-the-development-of-lung-cancer
#8
Weihao Li, Kai Huang, Fengbiao Wen, Guanghui Cui, Haizhou Guo, Song Zhao
Lung cancer remains the leading cause of cancer-related deaths throughout the world. In spite of great effort for the research of carcinogenesis, the molecular mechanisms of lung cancer remain unclear. In current study, we investigated the possible association between susceptibility of lung cancer and GAS5 rs145204276, which showed contradictory roles in carcinogenesis of colorectal cancer and hepatocellular carcinoma. We found that the del allele was significantly associated with 21% decreased risk of lung cancer (OR=0...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29180320/-low-expression-of-lncrna-gas5-promotes-epithelial-mesenchymal-transition-of-breast-cancer-cells-in-vitro
#9
Yong-Xing Ding, Ke-Cai Duan, Su-Lian Chen
OBJECTIVE: To investigate the role of long non-coding RNA growth arrest-specific transcript 5 (lncRNA-GAS5) in breast cancer progression and epithelial-mesenchymal transition (EMT) of the cancer cells. METHODS: Real-time quantitative PCR (qRT-PCR) was used to detect the expression of lncRNA-GAS5 in 37 pairs of breast cancer and adjacent non-tumor tissues and in parental MCF-7 cells and paclitaxel-resistant MCF-7 (MCF-7/PR) cells, and the correlation of lncRNA-GAS5 expression with the clinical stage and lymph node metastasis of breast cancer was investigated...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29170131/negative-regulation-of-lncrna-gas5-by-mir-196a-inhibits-esophageal-squamous-cell-carcinoma-growth
#10
Kai Wang, Juan Li, Gang Xiong, Gang He, Xingying Guan, Kang Yang, Yun Bai
MiR-196a could play important roles in carcinogenesis by targeting many protein coding genes. However, little is known about whether miR-196a can target any long non-coding RNAs (lncRNAs). In the present study, we screen lncRNAs which are regulated by miRNA-196a in human esophageal squamous cell carcinoma (ESCC). We found that miR-196a could suppress the expression of lncRNA growth arrest-specific 5(GAS5). GAS5 is frequently down-regulated in 86 paired human ESCC tissues. Importantly, there was lower GAS5 expression in the late stage of ESCC patients...
November 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29163187/prognostic-values-of-long-noncoding-rna-gas5-in-various-carcinomas-an-updated-systematic-review-and-meta-analysis
#11
Qunjun Gao, Haibiao Xie, Hengji Zhan, Jianfa Li, Yuchen Liu, Weiren Huang
The growth arrest-specific transcript 5 (GAS5) is a long noncoding RNA with low expression in multiple cancers. This meta-analysis aims to explore the association between GAS5 expression levels and cancer patients' prognosis. We collected all the relevant literatures about GAS5 expression levels associated with overall survival (OS), lymph node metastasis (LNM) and high tumor stage (II/III/IV) (HTS) from the PubMed and Web of Science. The hazard ratio (HR) and the corresponding 95% confidence interval (CI) were calculated to evaluate the link strength between GAS5 and cancer prognosis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29158265/topical-mevastatin-promotes-wound-healing-by-inhibiting-the-transcription-factor-c-myc-via-the-glucocorticoid-receptor-and-the-long-noncoding-rna-gas5
#12
Andrew P Sawaya, Irena Pastar, Olivera Stojadinovic, Sonja Lazovic, Stephen C Davis, Joel Gil, Robert S Kirsner, Marjana Tomic-Canic
Diabetic foot ulcers (DFU), a life-threatening complication of diabetes mellitus, have limited treatment options, often resulting in amputations. HMG-CoA reductase inhibitors such as statins are cholesterol-reducing agents that may provide a new therapeutic option. Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR). Here we demonstrate that the naturally occurring statin, mevastatin, reverses FPP's effects and promotes healing by using in vitro wound healing assays, human ex vivo and porcine in vivo wound models, and DFU tissue...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29137430/genome-wide-analysis-and-functional-prediction-of-long-non-coding-rnas-in-mouse-uterus-during-the-implantation-window
#13
Qi Wang, Nan Wang, Rui Cai, Fan Zhao, Yongjie Xiong, Xiao Li, Aihua Wang, Pengfei Lin, Yaping Jin
Establishment of the receptive uterus is a crucial step for embryo implantation. In this study, the expression profiles and characterization of long non-coding RNAs (lncRNAs) in pregnant mouse uteri on day 4, day 5 at implantation sites and inter-implantation sites were conducted using RNA-seq. A total of 7,764 putative lncRNA transcripts were identified, including 6,179 known lncRNA transcripts and 1,585 novel lncRNA transcripts. Bioinformatics analysis of the cis and trans lncRNA targets showed that the differentially expressed lncRNAs were mainly involved in tissue remodelling, immune response and metabolism-related processes, indicating that lncRNAs could be involved in the regulation of embryo implantation...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132937/arsenic-exposure-during-embryonic-development-alters-the-expression-of-the-long-noncoding-rna-growth-arrest-specific-5-gas5-in-a-sex-dependent-manner
#14
Kevin K Caldwell, Alexander Hafez, Elizabeth Solomon, Matthew Cunningham, Andrea M Allan
Our previous studies suggest that prenatal arsenic exposure (50ppb) modifies epigenetic control of the programming of the glucocorticoid receptor (GR) signaling system in the developing mouse brain. These deficits may lead to long-lasting consequences, including deficits in learning and memory, increased depressive-like behaviors, and an altered set-point of GR feedback throughout life. To understand the arsenic-induced changes within the GR system, we assessed the impact of in utero arsenic exposure on the levels of the GR and growth arrest-specific-5 (Gas5), a noncoding RNA, across a key gestational period for GR programming (gestational days, GD 14-18) in mice...
November 10, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29123179/association-of-long-noncoding-rnas-expression-levels-and-their-gene-polymorphisms-with-systemic-lupus-erythematosus
#15
Jun Li, Guo-Cui Wu, Tian-Ping Zhang, Xiao-Ke Yang, Shuang-Shuang Chen, Lian-Ju Li, Shu-Zhen Xu, Tian-Tian Lv, Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye
Increasing evidence has demonstrated the association between long noncoding RNAs (lncRNAs) and multiple autoimmune diseases. To explore four lncRNAs (GAS5, lnc-DC, linc0597 and linc0949) expression levels and gene polymorphisms in systemic lupus erythematosus (SLE), a two stage design was applied. In the first stage, 85 SLE patients and 71 healthy controls were enrolled to investigate the lncRNAs expression levels. Then, 1260 SLE patients and 1231 healthy controls were included to detect the single nucleotide polymorphisms (SNPs) in the differentially expressed lncRNAs identified in the first stage...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112934/long-non-coding-rna-gas5-antagonizes-the-chemoresistance-of-pancreatic-cancer-cells-through-down-regulation-of-mir-181c-5p
#16
Zhi-Qiang Gao, Jun-Feng Wang, De-Hua Chen, Xue-Song Ma, Wu Yang, Tang Zhe, Xiao-Wei Dang
OBJECTIVE: To explore the core mechanism of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in the regulation of multidrug resistance of pancreatic cancer cells. METHODS: mRNA levels of GAS5, miR-181c-5p and Hippo pathway related genes were detected by quantitative real-time PCR (qRT-PCR). Protein levels of MDR-1, MST1, YAP and TAZ were measured by western blot. Cell viability was detected by MTT assay. The combination between GAS5 and miR-181c-5p was confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assay...
November 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29098549/the-gas5-mir-222-axis-regulates-proliferation-of-gastric-cancer-cells-through-the-pten-akt-mtor-pathway
#17
Yanhua Li, Junjiao Gu, Hong Lu
BACKGROUND: Several lines of evidence have indicated that growth arrest-specific transcript 5 (GAS5) functions as a tumor suppressor and is aberrantly expressed in multiple cancers. GAS5 was found to be downregulated in gastric cancer (GC) tissues, and ectopic expression of GAS5 inhibited GC cell proliferation. AIMS: The present study aimed to explore the underlying mechanisms of GAS5 involved in GC cell proliferation. METHODS: GAS5 and miR-222 expressions in GC cell lines were estimated by quantitative real-time polymerase chain reaction...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29029523/systematic-review-and-meta-analysis-of-the-utility-of-long-non-coding-rna-gas5-as-a-diagnostic-and-prognostic-cancer-biomarker
#18
Wei Li, Na Li, Ke Shi, Qiong Chen
The growth arrest-specific 5 transcript (GAS5) is a long non-coding RNA (lncRNA) involved in the control of cell cycle progression and apoptosis in a wide variety of cells. To determine the clinical value of GAS5 expression in cancer patients, we performed a systematic review and meta-analysis exploring its association with the diagnosis, prognosis, and clinicopathological characteristics of cancer. Ten articles on prognosis, 15 on clinicopathology, and 5 on diagnosis were analyzed. Overall results showed that decreased GAS5 expression associated with unfavorable overall survival (OS) (HR = 2...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29025584/regulatory-mechanisms-of-long-noncoding-rnas-on-gene-expression-in-cancers
#19
REVIEW
Weiliang Sun, Yunben Yang, Chunjing Xu, Junming Guo
Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are non-protein coding transcripts longer than 200 nucleotides. In this review, we introduce the mechanisms by which lncRNAs regulate gene expression in four parts, epigenetic regulation (genetic imprinting and chromatin remodeling), transcriptional regulation (molecular decoy), post-transcriptional regulation (splicing and mRNA decay), and translational regulation. H19, Xist, and others are involved in genomic imprinting. HOTAIR and ANRIL function in chromatin remodeling...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28977945/genetic-polymorphisms-of-long-non-coding-rna-gas5-predict-platinum-based-concurrent-chemoradiotherapy-response-in-nasopharyngeal-carcinoma-patients
#20
Zhen Guo, Youhong Wang, Yu Zhao, Yi Jin, Liang An, Bin Wu, Zhaoqian Liu, Xiaoping Chen, Honghao Zhou, Hui Wang, Wei Zhang
LncRNA GAS5 plays a tumor suppressive role in a variety of human cancers and promises to be a novel diagnostic biomarker, therapy target, as well as prognostic biomarker. However, the role of GAS5 in nasopharyngeal carcinoma (NPC) remains elusive. The objective of the present study was to evaluate the effect of single nucleotide polymorphisms (SNPs) in GAS5 on treatment efficacy and toxicity in NPC patients receiving chemoradiotherapy. Three potentially functional SNPs of GAS5 were genotyped in 267 NPC patients and validated in another 238 NPC patients treated with chemoradiotherapy from southern China...
September 22, 2017: Oncotarget
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