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https://www.readbyqxmd.com/read/28619521/overview-of-long-non-coding-rna-and-mrna-expression-in-response-to-methamphetamine-treatment-in-vitro
#1
Kun Xiong, Lingling Long, Xudong Zhang, Hongke Qu, Haixiao Deng, Yanjun Ding, Jifeng Cai, Shuchao Wang, Mi Wang, Lvshuang Liao, Jufang Huang, Chunxia Yi, Jie Yan
Long non-coding RNAs (lncRNAs) display multiple functions including regulation of neuronal injury. However, their impact in methamphetamine (METH)-induced neurotoxicity has rarely been reported. Here, using microarray analysis, we investigated the expression profiling of lncRNAs and mRNAs in primary cultured prefrontal cortical neurons after METH treatment. We observed a difference in lncRNA and mRNA expression between the experimental and sham control groups. Using bioinformatics, we analyzed the highest enriched gene ontology (GO) terms of biological process, cellular component, and molecular function, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and pathway network analysis...
June 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28596501/identification-and-validation-long-non-coding-rnas-of-oral-squamous-cell-carcinoma-by-bioinformatics-method
#2
Meng Yang, Xingliang Xiong, Longcong Chen, Li Yang, Xian Li
Gene markers of oral squamous cell carcinoma (OSCC) have great significance on early diagnosis and treatment of clinical oral cancer. In this study, we used RNA-Seq data from OSCC patients and filtered differentially-expressed long non-coding RNA (lncRNA) to further clarify the molecular mechanism. Firstly, we downloaded datasets of OSCC from National Center for Biotechnology Information(NCBI), which were predicted and analyzed by cufflinks and tophat. Then, differentially expressed lncRNA enrichment was performed with The Database for Annotation, Visualization and Integrated Discovery (DAVID)...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28580301/adipose-stem-cells-from-obese-patients-show-specific-differences-in-the-metabolic-regulators-vitamin-d-and-gas5
#3
Laura M Pérez, Beatriz de Lucas, Victoria V Lunyak, Beatriz G Gálvez
Adipose tissue is a significant source of mesenchymal stem cells for regenerative therapies; however, caution should be taken as their environmental niche can affect their functional properties. We have previously demonstrated the negative impact of obesity on the function of adipose-derived stem cells (ASCs). Here we have evaluated other possible properties and targets that are altered by obesity such as the recently described long non-coding molecule Gas5, which is involved in glucocorticoid resistance. Using ASCs isolated from obese (oASCs) and control subjects (cASCs), we have analyzed additional metabolic and inflammatory conditions that could be related with their impaired therapeutic potential and consequently their possible usefulness in the clinic...
September 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28530127/an-oncolytic-adenovirus-expressing-snord44-and-gas5-exhibits-anti-tumor-effect-in-colorectal-cancer-cells
#4
Sujing Yuan, Yu Wu, Yigang Wang, Jianhua Chen, Liang Chu
SNORD44 is a C/D box small nucleolar RNA, and low expresses in breast cancer and head and neck squamous cell carcinoma tissues. Its host gene is growth arrest specific transcript 5 (GAS5), which is a long noncoding RNA. GAS5 is down-regulated in colorectal cancer (CRC), and overexpression of GAS5 suppresses cell proliferation. However, the function of SNORD44 in CRC remains largely unknown, and the application of SNORD44 combined with GAS5 in CRC treatment has not been reported. In this study, the expression levels of SNORD44 and GAS5 were measured in CRC tissues by qRT-PCR...
May 20, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28526319/lncrna-gas5-controls-cardiac-fibroblast-activation-and-fibrosis-by-targeting-mir-21-via-pten-mmp-2-signaling-pathway
#5
Hui Tao, Jia-Gui Zhang, Run-He Qin, Chen Dai, Peng Shi, Jing-Jing Yang, Zi-Yu Deng, Kai-Hu Shi
Long noncoding RNAs (LncRNAs) are aberrantly expressed in many diseases including cardiac fibrosis. LncRNA growth arrest-specific 5 (GAS5) is reported as a significant mediator in the control of cell proliferation and growth; however, the role and function in cardiac fibrosis remain unknown. In this study, we confirmed that GAS5 was lowly expressed in cardiac fibrosis tissues as well as activated cardiac fibroblast. Overexpression of GAS5 inhibited the proliferation of cardiac fibroblast. Moreover, microRNA-21 (miR-21) has been reported to be overexpressed in cardiac fibrosis tissues as well as activated cardiac fibroblast, which is responsible for the progression of cardiac fibrosis...
May 17, 2017: Toxicology
https://www.readbyqxmd.com/read/28521420/long-non-coding-rna-gas5-inhibits-cell-proliferation-induces-g0-g1-arrest-and-apoptosis-and-functions-as-a-prognostic-marker-in-colorectal-cancer
#6
Yang Yang, Zhanlong Shen, Yichao Yan, Bo Wang, Jizhun Zhang, Chao Shen, Tao Li, Chunxiang Ye, Zhidong Gao, Guo Peng, Yingjiang Ye, Kewei Jiang, Shan Wang
Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators of carcinogenesis. Growth arrest specific 5 (GAS5), a lncRNA, is known to be aberrantly expressed in several types of cancer, however, the role of GAS5 in CRC remains unclear. In the present study, GAS5 mRNA expression was measured in CRC and adjacent normal mucosa tissue samples from 53 patients using reverse transcription-quantitative polymerase chain reaction analysis, in addition to seven CRC cell lines...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28519068/long-noncoding-rna-gas5-suppresses-cell-growth-and-epithelial-mesenchymal-transition-in-osteosarcoma-by-regulating-the-mir-221-arhi-pathway
#7
Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan
Dysregulated long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in the development of human cancers. The lncRNA growth arrest-specific 5 (GAS5) is reported to be a tumor suppressor in multiple cancers. However, the roles of GAS5 and its related miRNAs in osteosarcoma are poorly understood. This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR-221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real-time PCR (RT-qPCR)...
May 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28506768/low-expression-of-long-non-coding-rna-gas5-is-associated-with-poor-prognosis-of-patients-with-thyroid-cancer
#8
Ling-Ji Guo, Shu Zhang, Bo Gao, Yan Jiang, Xiao-Hua Zhang, Wu-Guo Tian, Shuai Hao, Jian-Jie Zhao, Gang Zhang, Chun-Yan Hu, Jie Yan, Dong-Lin Luo
The study aims to investigate the role of long non-coding RNA (lncRNA) GAS5 in the diagnosis and prognosis of patients suffering from thyroid cancer (TC). A total of 212 patients with TC and 61 patients with benign thyroid tumor were enrolled in the study. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect the lncRNA GAS5 expression in TC and benign tumor tissues. All TC patients were categorized into high-risk and low-risk groups according to the MACIS, AGES and AMES prognostic scoring system...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28472815/long-noncoding-rna-gas5-which-acts-as-a-tumor-suppressor-via-microrna-21-regulates-cisplatin-resistance-expression-in-cervical-cancer
#9
Qirong Wen, Yan Liu, Huabing Lyu, Xiaying Xu, Qingxia Wu, Ni Liu, Qi Yin, Juan Li, Xiujie Sheng
OBJECTIVES: The aims of this study were to investigate the functions of GAS5 as a tumor suppressor in cervical cancer and explore the mechanism. METHODS: The expression of GAS5 and microRNA 21 (miR-21) was detected in primary cervical cancer tissue specimens, as well as in cervical cancer cell lines. We identified the interaction of GAS5 and miR-21 by quantitative polymerase chain reaction, Western blot, and dual-luciferase reporter assay. We also studied the functions of GAS5 in proliferation, apoptosis, migration, and invasion in cervical cancer cells in vitro and vivo...
May 2, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28451400/accumulation-of-gas5-in-exosomes-is-a-marker-of-apoptosis-induction
#10
Oguz Koldemir, Emre Özgür, Ugur Gezer
Long non-coding RNAs (lncRNAs) are key regulatory molecules in many fundamental cellular processes and their deregulation is assumed to contribute to carcinogenesis. Exosomal lncRNAs are thought to be involved in the dissemination of cell signals to control local cellular microenvironments. In the current study, exosomal expression of growth arrest specific 5 (GAS5), an inhibitor of cell proliferation and promoter of apoptosis, was evaluated in apoptotic processes initiated by different mechanisms. Therefore, MCF-7 and MDA-MB-231 breast cancer cells were treated with Taxol (2 and 10 nM) and bleomycin (2 and 10 ng/ml) for 24 h...
March 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28430799/diagnostic-and-prognostic-value-of-long-noncoding-rnas-as-biomarkers-in-urothelial-carcinoma
#11
Johanna Droop, Tibor Szarvas, Wolfgang A Schulz, Christian Niedworok, Günter Niegisch, Kathrin Scheckenbach, Michèle J Hoffmann
Many long noncoding RNAs (lncRNAs) are deregulated in cancer and contribute to oncogenesis. In urothelial carcinoma (UC), several lncRNAs have been reported to be overexpressed and proposed as biomarkers. As most reports have not been confirmed independently in large tissue sets, we aimed to validate the diagnostic and prognostic value of lncRNA upregulation in independent cohorts of UC patients. Thus, expression of seven lncRNA candidates (GAS5, H19, linc-UBC1, MALAT1, ncRAN, TUG1, UCA1) was measured by RT-qPCR in cell lines and tissues and correlated to clinicopathological parameters including follow-up data (set 1: N n = 10; T n = 106)...
2017: PloS One
https://www.readbyqxmd.com/read/28423570/identification-of-long-non-coding-rnas-gas5-linc0597-and-lnc-dc-in-plasma-as-novel-biomarkers-for-systemic-lupus-erythematosus
#12
Guo-Cui Wu, Jun Li, Rui-Xue Leng, Xiang-Pei Li, Xiao-Mei Li, De-Guang Wang, Hai-Feng Pan, Dong-Qing Ye
Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs in systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore the plasma levels of five lncRNAs (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) and their potential as SLE biomarkers. Compared with healthy controls, plasma levels of GAS5 and lnc-DC were significantly decreased (P < 0.001 and P = 0.002, respectively) while linc0597 were overexpressed in SLE patients (P < 0...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396462/lncrna-gas5-inhibits-cellular-proliferation-by-targeting-p27kip1
#13
Gang Luo, Dong Liu, Chao Huang, Miao Wang, Xingyuan Xiao, Fuqing Zeng, Liang Wang, Guosong Jiang
Recent studies have demonstrated that long non-coding RNAs (lncRNAs) have important roles in cancer biology, and that the downregulation of lncRNA growth arrest-specific transcript 5 (GAS5) has been reported in a variety of human cancers. However, its role in prostate cancer is largely unknown. This study aims investigated the biological role and underlying mechanism of GAS5 on proliferation in prostate cancer. The results demonstrate that GAS5 expression is significantly decreased in prostate cancer cells compared with prostate epithelial cells...
April 10, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28386376/long-non-coding-rna-gas5-inhibits-tumorigenesis-via-mir-137-in-melanoma
#14
Donghui Bian, Wen Shi, Yang Shao, Peilong Li, Guodong Song
Melanoma is the leading cause of death in patients with skin cancer. In the present study, we aimed to prove the functions and molecular mechanisms of lncRNA-GAS5 in melanoma. Herein, we found that the expression of GAS5 was down-regulated in melanoma tissues compared to adjacent normal tissues. GAS5 was significantly associated with distal metastasis and TNM stage in melanoma. Furthermore, we found that GAS5 suppressed melanoma cell proliferation, migration and invasion. Then, we found thatmiR-137 was decreased in melanoma tissues compared to adjacent normal tissues and was correlated with GAS5...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28339045/identification-of-circulating-long-non-coding-rna%C3%A2-gas5-as-a-potential-biomarker-for-non-small-cell-lung-cancer-diagnosisnon-small-cell-lung-cancer-long-non-coding-rna-plasma-gas5-biomarker
#15
Qian Tan, Jiangcheng Zuo, Shili Qiu, Yalan Yu, Hu Zhou, Nandi Li, Hui Wang, Chunzi Liang, Mingxia Yu, Jiancheng Tu
Non-small cell lung cancer (NSCLC) is one of the most malignant cancers in the world. Early diagnosis of NSCLC has become especially important for patient treatment and prognosis. Increasing evidence suggest that long non-coding RNA GAS5 plays vital roles in cancer proliferation and differentiation in NSCLC. However, its clinical value in the diagnosis of NSCLC is unclear. The objective of this study was to evaluate the importance of circulating GAS5 as a biomarker for NSCLC diagnosis. In our study, quantitative real-time PCR (QRT-PCR) was applied to detect the GAS5 expression level in 80 pairs of cancer tissues and 57 pairs of plasma samples of NSCLC patients...
March 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28252643/2-o-methylmagnolol-upregulates-the-long-non-coding-rna-gas5-and-enhances-apoptosis-in-skin-cancer-cells
#16
Tong-Hong Wang, Chieh-Wen Chan, Jia-You Fang, Ya-Min Shih, Yi-Wen Liu, Tzu-Chien V Wang, Chi-Yuan Chen
Magnolol, a hydroxylated biphenol compound isolated from the bark of Magnolia officinalis, has been shown to exhibit anti-proliferative effect in various cancer cells, including skin cancer cells. Methoxylation of magnolol appears to improve its anti-inflammatory activity, yet the effect of this modification on the agent's antitumor activity remains unknown. In this work, we report that 2-O-methylmagnolol (MM1) displays improved antitumor activity against skin cancer cells compared to magnolol both in vitro and in vivo...
March 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28214888/analysis-of-long-non-coding-rna-expression-of-lymphatic-endothelial-cells-in-response-to-type-2-diabetes
#17
Min Qi, Qiuhong Zhou, Weiqi Zeng, Minxue Shen, Xiaomin Liu, Chang Luo, Jing Long, Wangqing Chen, Jianglin Zhang, Siyu Yan
BACKGROUND: Recent evidence has indicated that long non-coding RNA (lncRNA) is involved in the pathogenesis of type 2 diabetes, but nothing is known about lncRNA expression changes of lymphatic endothelial cells in response to type 2 diabetes. METHODS: The GSE38396 dataset was downloaded from the Gene Expression Omnibus database and the probe sets of Human Gnome U133 Plus2.0 microarray were annotated for lncRNA. Differentially expressed lncRNAs between diabetic and non-diabetic lymphatic endothelial cells were calculated...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28117028/lncrna-gas5-inhibits-tumorigenesis-and-enhances-radiosensitivity-by-suppressing-mir-135b-expression-in-non-small-cell-lung-cancer
#18
Yingbo Xue, Tingting Ni, Ying Jiang, Yong Li
GAS5 has been demonstrated to be correlated with clinicopathological characteristics and serve as a tumor suppressor innon small cell lung cancer (NSCLC). However, the underlying mechanism of competing endogenous RNA (ceRNA) regulatory network involving GAS5 in NSCLC remains to be elucidated. In this study, qRT-PCR results showed that GAS5 was down-regulated and miR-135b was up-regulated in NSCLC tissues and cells. The expressions of GAS5 and miR-135b changed inversely in response to irradiation. Gain of function experiments revealed that GAS5 overexpresion and miR-135b downregulation significantly suppressed tumorigenesis by repressing cell proliferation, invasion and enhanced radiosensitivity of NSCLC cells by reducing colony formation rates...
January 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28099146/long-non-coding-rna-growth-arrest-specific-transcript-5-acts-as-a-tumour-suppressor-in-colorectal-cancer-by-inhibiting-interleukin-10-and-vascular-endothelial-growth-factor-expression
#19
Yuan Li, Yan Li, Shengkai Huang, Kun He, Mei Zhao, Hong Lin, Dongdong Li, Jiaming Qian, Caihong Zhou, Yuhua Chen, Changzhi Huang
Long non-coding RNAs (lncRNAs) are highly involved in diverse biological processes of human malignancies. The expression profile and underlying mechanism of lncRNA growth arrest specific transcript 5 (GAS5) in colorectal cancer (CRC) is poorly understood. In this study, we found that GAS5 was commonly downregulated in CRC tissues, serum of CRC patients and CRC cell lines. Knockdown of GAS5 promoted CRC cell proliferation and colony formation, whereas overexpression of GAS5 produced the opposite result. We further demonstrated that knockdown of GAS5 increased the expression and secretion of interleukin-10 (IL-10) and vascular endothelial growth factor (VEGF-A) via NF-κB and Erk1/2 pathways...
February 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059053/long-noncoding-rna-gas5-suppresses-tumorigenesis-by-inhibiting-mir-23a-5-expression-in-non-small-cell-lung-cancer
#20
Yongcheng Mei, Jinchun Si, Yun Wang, Zhuangshi Huang, Haiwen Zhu, Shijun Feng, Xuezhi Wu, Liwen Wu
Previous studies reported that elevated expression of long noncoding RNA GAS5 led to NSCLC cell growth arrest and a promotion of apoptosis both <em>in vitro</em> and <em>in vivo</em>. However, its underlying molecular mechanism in NSCLC is still unclear. In the present study, we noted that GAS5 was down-regulated in NSCLC tissues and cells and was negatively correlated with miR-23a expression. Luciferase reporter assay and qRT-PCR analysis demonstrated that GAS5 directly interacted with miR-23a and reversely regulate its expression...
January 5, 2017: Oncology Research
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