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https://www.readbyqxmd.com/read/29785740/expression-levels-of-breast-cancer-related-gas5-and-lsinct5-lncrnas-in-cancer-free-breast-tissue-molecular-associations-with-age-at-menarche-and-obesity
#1
Yaser Mansoori, Mohammad Bagher Tabei, Alireza Askari, Pantea Izadi, Abdolreza Daraei, Milad Bastami, Mohammad Mehdi Naghizadeh, Ziba Nariman-Saleh-Fam, Behnam Mansoori, Javad Tavakkoly-Bazzaz
Long noncoding RNAs (lncRNAs) constitute a major class of the human transcriptome which play crucial roles in the key biological processes of both normal and malignant breast cells. Although the aberrant expression of lncRNAs has been well-documented in breast cancer (BC), little is currently known about the association between their expression levels in the breast tissue of healthy women and BC risk factors, especially the reproductive or demographic characteristics that are among the most well-known BC risk modifiers...
May 21, 2018: Breast Journal
https://www.readbyqxmd.com/read/29749482/a-panel-of-7-prognosis-related-long-non-coding-rnas-to-improve-platinum-based-chemoresistance-prediction-in-ovarian-cancer
#2
Jing Song, Wanfeng Zhang, Sen Wang, Kun Liu, Fangzhou Song, Longke Ran
In order to study the role of long non-coding RNAs (lncRNAs) in predicting platinum-based chemoresistance in patients with high-grade serous ovarian carcinoma (HGS-OvCa), a=7-lncRNA signature was developed by analyzing 561 microarrays and 136 specimens from RNA-sequencing (RNA-seq) obtained from online databases [odds ratio (OR), 2.859; P<0.0001]. The upregulated lncRNAs (RP11-126K1.6, ZBED3-AS1, RP11-439E19.10 and RP11‑348N5.7) and downregulated lncRNAs [RNF144A-AS1, growth arrest specific 5 (GAS5) and F11-AS1] exhibited high sensitivity and specificity in predicting chemoresistance in the Gene Expression Omnibus and the Cancer Genome Atlas (area under curve >0...
May 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29748618/the-long-noncoding-rna-gas5-negatively-regulates-the-adipogenic-differentiation-of-mscs-by-modulating-the-mir-18a-ctgf-axis-as-a-cerna
#3
Ming Li, Zhongyu Xie, Peng Wang, Jinteng Li, Wenjie Liu, Su'an Tang, Zhenhua Liu, Xiaohua Wu, Yanfeng Wu, Huiyong Shen
Mesenchymal stem cells (MSCs) are important pluripotent stem cells and a major source of adipocytes in the body. However, the mechanism of adipogenic differentiation has not yet been completely elucidated. In this study, the long noncoding RNA GAS5 was found to be negatively correlated with MSC adipogenic differentiation. GAS5 overexpression negatively regulated adipocyte formation, whereas GAS5 knockdown had the opposite effect. Further mechanistic analyses using luciferase reporter assays revealed that GAS5 regulates the adipogenic differentiation of MSCs by acting as competing endogenous RNA (ceRNA) to sponge miR-18a, which promotes adipogenic differentiation...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29745062/long-non-coding-rna-gas5-is-induced-by-interferons-and-plays-an-antitumor-role-in-esophageal-squamous-cell-carcinoma
#4
Jianbing Huang, Yuan Li, Zhiliang Lu, Yun Che, Shouguo Sun, Shuangshuang Mao, Yuanyuan Lei, Ruochuan Zang, Ning Li, Nan Sun, Jie He
The long non-coding RNA GAS5 has been reported as a tumor suppressor in many cancers. However, its functions and mechanisms remain largely unknown in esophageal squamous cell carcinoma (ESCC). In this study, we found that GAS5 was over-expressed in ESCC tissue compared with that in normal esophageal tissue in a public database. Functional studies showed that GAS5 could inhibit ESCC cell proliferation, migration and invasion in vitro. Further analysis revealed that GAS5 was regulated by interferon (IFN) responses via the JAK-STAT pathway...
May 9, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29737538/long-non-coding-rna-gas5-aggravates-hypoxia-injury-in-pc-12-cells-via-down-regulating-mir-124
#5
Xiaoli Hu, Juan Liu, Gang Zhao, Jiaping Zheng, Xia Qin
One important feature of cerebral ischemia is hypoxia injury in nerve cells. Growth arrest-specific transcript 5 (GAS5) is widely reported as a tumor suppressor gene; however, the investigations about its role in cerebrovascular disease are relatively rare. This study was aimed to explore the impact of GAS5 on hypoxia response in nervous cells. PC-12 cells were incubated under anoxic condition to induce hypoxia injury. Regulatory effects of GAS5 on miR-124 and miR-124 on ICAM-1 expression were assessed by qRT-PCR and/or Western blot...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29675399/sialidase-deficiency-in-porphyromonas-gingivalis-increases-il-12-secretion-in-stimulated-macrophages-through-regulation-of-cr3-incrna-gas5-and-mir-21
#6
Xue Yang, Yaping Pan, Xiaoyu Xu, Tong Tong, Shiwen Yu, Yue Zhao, Li Lin, Jingbo Liu, Dongmei Zhang, Chen Li
Porphyromonas gingivalis ( P. gingivalis ) is a major periodontal pathogen that can induce an immune response leading to a destructive inflammatory process. During the inflammatory process, interleukin-12 (IL-12) is secreted, correlating with bacterial clearance by macrophages. Bacterial sialidase has recently been shown to influence the synthesis and modification of the macromolecules on its surface, and is associated with the interaction between bacteria and host cells. We have previously constructed a P...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29660898/down-regulation-of-long-non-coding-rna-gas5-as1-and-its-prognostic-and-diagnostic-significance-in-hepatocellular-carcinoma
#7
Yingchao Wang, Wei Jing, Weijie Ma, Chunzi Liang, Hongyan Chai, Jiancheng Tu
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common solid tumor in global range, with high degree of malignancy and poor prognosis. But the relationship between the expression of GAS5-AS1 and HCC is not documented. This study aimed to profile GAS5-AS1 expression signature and then to explore its clinical significance in HCC. METHODS: Quantitative real-time PCR (RT-qPCR) was performed to detect the expression of GAS5-AS1 in 83 pairs of HCC surgical tissues and adjacent normal liver tissues...
April 2, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29655698/down-regulation-of-lncrna-gas5-decreases-chemotherapeutic-effect-of-dendrosomal-curcumin-dnc-in-breast-cancer-cells
#8
Mohammad Javad Dehghan Esmatabadi, Maryam Motamedrad, Majid Sadeghizadeh
BACKGROUND: Despite positive results obtained from anticancer activities of curcumin, there are some obstacles that limit its use as an anticancer agent. HYPOTHESIS/PURPOSE: Different methods such as employing the dendrosomal curcumin (DNC) were examined to overcome such problems. There is increasing evidence representing long non-coding RNAs play important roles in biological processes. In this study, we focused on the roles of GAS5 in the anti-cancer effects of DNC on breast cancer...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29648472/downregulation-of-serum-long-noncoding-rna-gas5-may-contribute-to-insulin-resistance-in-pcos-patients
#9
Haiyan Lin, Weijie Xing, Yu Li, Yanxin Xie, Xiaoshi Tang, Qingxue Zhang
Polycystic ovary syndrome (PCOS) is a common endocrine disease that affects reproductive-aged women and mostly characterized by insulin resistance (IR). The underlying mechanism remains unknown. Long noncoding RNAs (lncRNAs) have been demonstrated to be involved in various levels of biological regulation process of cell development, metabolism, and differentiation. This study aims to investigate the relationship between IR and differential expression of lncRNA Growth-arrest specific transcript 5 (GAS5) in patients' serum with and without PCOS...
April 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29620929/long-non-coding-rna-gas5-inhibits-hiv-1-replication-through-interaction-with-mir-873
#10
Liujun Chen, Lang Chen, Luoshiyuan Zuo, Ziang Gao, Yingying Shi, Peipei Yuan, Song Han, Jun Yin, Biwen Peng, Xiaohua He, Wanhong Liu
The human immunodeficiency virus (HIV) is the causative pathogen of acquired immunodeficiency syndrome (AIDS), which has generated worldwide concern. Long non-coding RNAs (lncRNAs) are a rising star in virus-host cross-talk pathways; they are differentially expressed during many viral infections and are involved in multiple biological processes. Currently, lncRNA growth arrest-specific transcript 5 (GAS5) is known to be down-regulated during HIV-1 infection. However, the functions and mechanisms of GAS5 in HIV-1 infection remain largely unknown...
March 12, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29602737/polymorphism-in-the-promoter-region-of-lncrna-gas5-is-functionally-associated-with-the-risk-of-gastric-cancer
#11
Qianjun Li, Gang Ma, Suhua Sun, Ying Xu, Bingjian Wang
BACKGROUND AND AIMS: Previous studies showed that down-regulation of GAS5 was involved in the development of gastric cancer (GC). However, the regulatory mechanism of down-expressed GAS5 in GC remains obscure. We aimed to investigate the role of rs145204276 of GAS5 in the development and metastasis process of GC. METHODS: 853 GC patients and 954 healthy controls were recruited. The variant rs145204276 was genotyped and the Chi2 test was used to compare the frequency of the genotype and the allele between the patients and the controls...
March 27, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29562912/gas5-is-an-essential-lncrna-regulator-for-self-renewal-and-pluripotency-of-mouse-embryonic-stem-cells-and-induced-pluripotent-stem-cells
#12
Jiajie Tu, Geng Tian, Hoi-Hung Cheung, Wei Wei, Tin-Lap Lee
BACKGROUND: The regulatory role of long noncoding RNAs (lncRNAs) have been partially proved in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). METHODS: In the current study, we investigated mouse ESC (mESC) self-renewal, differentiation, and proliferation in vitro by knocking down a lncRNA, growth arrest specific 5 (Gas5). A series of related indicators were examined by cell counting kit-8 (CCK-8) assay, quantitative reverse-transcription polymerase chain reaction (qRT-PCR), Western blot, alkaline phosphatase staining, propidium iodide (PI) staining, Annexin V staining, competition growth assay, immunofluorescence, and chromatin immunoprecipitation (ChIP)-qPCR...
March 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29557411/the-variant-rs145204276-of-gas5-is-associated-with-the-development-and-prognosis-of-gastric-cancer
#13
Qianjun Li, Gang Ma, Huimin Guo, Suhua Sun, Ying Xu, Bingjian Wang
BACKGROUND AND AIMS: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues. METHOD: 1,253 GC patients and 1,354 healthy controls were included...
March 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29552716/microarray-expression-profiling-and-co-expression-network-analysis-of-circulating-lncrnas-and-mrnas-associated-with-neurotoxicity-induced-by-bpa
#14
Wei Pang, Fu-Zhi Lian, Xue Leng, Shu-Min Wang, Yi-Bo Li, Zi-Yu Wang, Kai-Ren Li, Zhi-Xian Gao, Yu-Gang Jiang
A growing body of evidence has shown bisphenol A (BPA), an estrogen-like industrial chemical, has adverse effects on the nervous system. In this study, we investigated the transcriptional behavior of long non-coding RNAs (lncRNAs) and mRNAs to provide the information to explore neurotoxic effects induced by BPA. By microarray expression profiling, we discovered 151 differentially expressed lncRNAs and 794 differentially expressed mRNAs in the BPA intervention group compared with the control group. Gene ontology analysis indicated the differentially expressed mRNAs were mainly involved in fundamental metabolic processes and physiological and pathological conditions, such as development, synaptic transmission, homeostasis, injury, and neuroinflammation responses...
March 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29516641/cell-free-lncrna-expression-signatures-in-urine-serve-as-novel-non-invasive-biomarkers-for-diagnosis-and-recurrence-prediction-of-bladder-cancer
#15
Lutao Du, Weili Duan, Xiumei Jiang, Li Zhao, Juan Li, Rui Wang, Suzhen Yan, Yujiao Xie, Keqiang Yan, Qingliang Wang, Lili Wang, Yongmei Yang, Chuanxin Wang
Cell-free long non-coding RNAs (lncRNAs) are stably present in urine and can serve as non-invasive biomarkers for cancer. We aimed to identify signatures of lncRNAs in urine for diagnosis and prognosis of bladder cancer (BC). Screening of lncRNAs by microarray analysis was performed using urine samples of 10 BC patients and 10 controls. Expressions of candidate lncRNAs were evaluated in the training and validation set including 230 BC patients and 230 controls by quantitative reverse transcription polymerase chain reaction (qRT-PCR)...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29509242/correlation-between-long-strand-non-coding-rna-gass-expression-and-prognosis-of-cervical-cancer-patients
#16
Y Li, Y-P Wan, Y Bai
OBJECTIVE: Cervical cancer is the second popular female specific malignant tumors. Long-strand non-coding RNA (lncRNA) GAS5 (Growth Arrest Specific 5) participates in pathological processes of various malignant tumors. This study aimed at investigating the correlation between lncRNA GAS5 expression and prognosis of cervical cancer patients. PATIENTS AND METHODS: Cancer tissues were collected from 48 cervical cancer patients. GAS5 expression in cervical cancer cells was determined by qRT-PCR and in situ hybridization (ISH)...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29509235/long-non-coding-rna-gas5-contributed-to-the-development-of-glaucoma-via-regulating-the-tgf-%C3%AE-signaling-pathway
#17
Y Xu, Y-Q Xing
OBJECTIVE: We aimed at discussing the biological function of lncRNA GAS5 (Growth Arrest Specific 5) on the proliferative, apoptotic and differentiative abilities of retinal ganglion cells. MATERIALS AND METHODS: GAS5 expression was knocked down by transfection with siRNA targeting GAS5 (siGAS5) in retinal ganglion cells. After transfection, qRT-PCR was utilized to evaluate the mRNA level of GAS5 expression. The protein levels of smad2 and smad3 were detected by Western blot...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29490650/long-non-coding-rna-gas5-regulates-proliferation-and-apoptosis-in-hcs-2-8-cells-and-growth-plate-chondrocytes-by-controlling-fgf1-expression-via-mir-21-regulation
#18
Xiong Liu, Yuqi She, Hongrong Wu, Da Zhong, Jian Zhang
BACKGROUND: LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined. METHODS: The overexpression and knockdown models of Gas5 and miR-21 in cells and animals were constructed. Cell survival was determined by MTT assay and flow cytometry. Animal biochemical indices were measured by enzyme-linked immunosorbent assay, hematoxylin/eosin staining, immunohistochemistry or in situ hybridisation...
February 28, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29448248/lncrna-gas5-overexpression-reverses-lps-induced-inflammatory-injury-and-apoptosis-through-up-regulating-klf2-expression-in-atdc5-chondrocytes
#19
Feng Li, Jianguang Sun, Shilei Huang, Gao Su, Guofu Pi
BACKGROUND/AIMS: Osteoarthritis (OA) is the most frequently occurring joint disease and characterized by degeneration of cartilage. As the unique cell type in cartilage, chondrocytes play a crucial role during OA. Our study explored the influence of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) on lipopolysaccharides (LPS)-induced injury in ATDC5 cells. METHODS: Cell viability, apoptosis and expression of inflammatory cytokines were all assessed to evaluate LPS-induce inflammatory injury...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29445179/long-noncoding-rna-gas5-promotes-bladder-cancer-cells-apoptosis-through-inhibiting-ezh2-transcription
#20
Miao Wang, Chen Guo, Liang Wang, Gang Luo, Chao Huang, Yawei Li, Dong Liu, Fuqing Zeng, Guosong Jiang, Xingyuan Xiao
Aberrant expression of long noncoding RNA GAS5 in bladder cancer (BC) cells was identified in recent studies. However, the regulatory functions and underlying molecular mechanisms of GAS5 in BC development remain unclear. Here, we confirmed that there was a negative correlation between GAS5 level and bladder tumor clinical stage. Functionally, overexpression of GAS5 reduced cell viability and induced cell apoptosis in T24 and EJ bladder cancer cells. Mechanistically, GAS5 effectively repressed EZH2 transcription by directly interacting with E2F4 and recruiting E2F4 to EZH2 promoter...
February 14, 2018: Cell Death & Disease
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