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https://www.readbyqxmd.com/read/27878359/long-noncoding-rna-gas5-inhibits-malignant-proliferation-and-chemotherapy-resistance-to-doxorubicin-in-bladder-transitional-cell-carcinoma
#1
Hui Zhang, Yan Guo, Yongsheng Song, Chao Shang
PURPOSE: Bladder cancer is the most general malignant cancer in genitourinary system, more than 90% of BCs are bladder transitional cell carcinomas (BTCC). This study aimed to investigate the clinical significance of growth arrest-specific 5 (GAS5) gene and its regulatory effects of malignant proliferation and chemotherapy resistance to doxorubicin in BTCC cells. METHODS: The expression of GAS5 was detected by quantitative real-time PCR. Statistical analysis was used to determine the relationship between GAS5 expression and clinical features and the prognostic value of GAS5 for disease free survival...
November 22, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27863421/lncrna-gas5-contributes-to-lymphatic-metastasis-in-colorectal-cancer
#2
Yongbin Zheng, Dan Song, Kuang Xiao, Cao Yang, Yu Ding, Wenhong Deng, Shilun Tong
Colorectal cancer (CRC) ranks the third most common type of cancer worldwide. However, the detailed molecular mechanisms underlying these processes are poorly understood. Recent studies have shown that lncRNAs play important roles in carcinogenesis and progression of CRC. The lncRNA growth arrest special 5 (GAS5), was previously identified to be down-regulated and functions as a tumor suppressor gene in many kinds of cancers. In current two-stage, case-control study, we systematically evaluated the potential role of lncRNA GAS5 and its genetic variation rs145204276 in the development and metastasis process of CRC in a Chinese population...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27827524/long-non-coding-rna-gas5-acts-as-a-molecular-sponge-to-regulate-mir-23a-in-gastric-cancer
#3
Xiao Liu, Tongli Jiao, Yinzhong Wang, Weiqiang Su, Zhaopeng Tang, Chaoyang Han
BACKGROUND: Long non-coding RNA (lncRNAs) play critical roles in the development of cancers. LncRNA GAS5 was identified to be involved in tumorigenesis of several cancers. However, its role and function in gastric cancer (GC) remains unknown. METHODS: The expression of GAS5, miR-23a and MT2A in 24 paired GC tissues was detected by qRT-PCR and subjected to correlation analysis. Bio-informatics analysis was performed by using DIANA Tools. Abnormal GAS5 expression was conducted in GC cells to analyze its regulation on miR-23a and MT2A via using qRT-PCR, western blot and luciferase reporter assay...
November 9, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27823999/microrna-210-plays-a-critical-role-in-the-angiogenic-effect-of-isoprenaline-on-human-umbilical-vein-endothelial-cells-via-regulation-of-noncoding-rnas
#4
You-You Yan, Zhi-Hui Wang, Lei Zhao, Dan-Dan Song, Chao Qi, Lu-Lu Liu, Jun-Nan Wang
BACKGROUND: β-adrenoceptors play a crucial regulatory role in blood vessel endothelial cells. Isoprenaline (ISO, a β-adrenergic agonist) has been reported to promote angiogenesis through upregulation of vascular endothelial growth factor (VEGF) expression; however, the underlying mechanism remains to be investigated. It is widely accepted that certain noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), can regulate endothelial cell behavior, including their involvement in angiogenesis...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27811843/long-non-coding-rna-gas5-controls-human-embryonic-stem-cell-self-renewal-by-maintaining-nodal-signalling
#5
Chen Xu, Yan Zhang, Qiaoling Wang, Zhenyu Xu, Junfeng Jiang, Yuping Gao, Minzhi Gao, Jiuhong Kang, Minjuan Wu, Jun Xiong, Kaihong Ji, Wen Yuan, Yue Wang, Houqi Liu
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of the self-renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs remain uncharacterized. Here we demonstrate that growth-arrest-specific transcript 5 (GAS5), a known tumour suppressor and growth arrest-related lncRNA, is highly expressed and directly regulated by pluripotency factors OCT4 and SOX2 in hESCs. Phenotypic analysis shows that GAS5 knockdown significantly impairs hESC self-renewal, but its overexpression significantly promotes hESC self-renewal...
November 4, 2016: Nature Communications
https://www.readbyqxmd.com/read/27779700/decreased-expression-of-long-non-coding-rna-gas5-promotes-cell-proliferation-migration-and-invasion-and-indicates-a-poor-prognosis-in-ovarian-cancer
#6
Jie Li, He Huang, Yingguang Li, Li Li, Wenhui Hou, Zeshan You
Long non-coding RNA growth arrest-specific 5 (GAS5) was reported to be aberrantly expressed in various types of cancers. However, the role of GAS5 in the evolution and progression of ovarian cancer remains elusive. In the present study, we aimed to investigate the cellular function and clinical significance of GAS5 in ovarian cancer. GAS5 expression levels in 63 ovarian cancer tissues were detected by quantitative real-time PCR. Cell Counting Kit-8 (CCK-8) assay was performed to analyze the effect of GAS5 on cell proliferation...
October 24, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27743383/lncrna-gas5-inhibits-proliferation-and-progression-of-prostate-cancer-by-targeting-mir-103-through-akt-mtor-signaling-pathway
#7
Dong Xue, Cuixing Zhou, Hao Lu, Renfang Xu, Xianlin Xu, Xiaozhou He
In prior research, evidence has been found for a relation between low exposure of long non-coding RNAs (lncRNAs) and prostate tumor genesis. This study aims to clarify the underlying mechanisms of lncRNA GAS5 in prostate cancer (PCa). In total, 118 pairs of PCa tissues and matched adjacent non-tumor tissues were collected. Additionally, lncRNA GAS5 exposure levels were determined using RT-PCR and in situ hybridization. In addition, dual-luciferase report assay was performed to verify the target effect of lncRNA GAS5 on miR-103...
October 14, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27631209/circulating-long-noncoding-rna-gas5-is-a-novel-biomarker-for-the-diagnosis-of-nonsmall-cell-lung-cancer
#8
Wenjun Liang, Tangfeng Lv, Xuefei Shi, Hongbing Liu, Qingqing Zhu, Junli Zeng, Wen Yang, Jie Yin, Yong Song
The recently discovered long noncoding RNAs have the potential to regulate many biological processes, which are aberrantly expressed in many tumor types. Our previous study showed that the long noncoding RNA-growth arrest-specific transcript 5 (GAS5) was decreased in lung cancer tissue, which contributed to the proliferation and apoptosis of nonsmall cell lung cancer (NSCLC). GAS5 was also associated with the prognosis of lung cancer patients. These results suggest that GAS5 may represent a novel prognostic indicator and a target for gene therapy in NSCLC...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27494402/detection-of-long-non-coding-rnas-in-human-breastmilk-extracellular-vesicles-implications-for-early-child-development
#9
Oskar Karlsson, Rodosthenis S Rodosthenous, Calvin Jara, Kasey J Brennan, Robert O Wright, Andrea A Baccarelli, Rosalind J Wright
Breastmilk has many documented beneficial effects on the developing human infant, but the components of breastmilk that influence these developmental pathways have not been fully elucidated. Increasing evidence suggests that non-coding RNAs encapsulated in extracellular vesicles (EVs) represent an important mechanism of communication between the mother and child. Long non-coding RNAs (lncRNAs) are of particular interest given their key role in gene expression and development. However, it is not known whether breastmilk EVs contain lncRNAs...
August 5, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27489122/downregulation-of-the-long-noncoding-rna-gas5-as1-contributes-to-tumor-metastasis-in-non-small-cell-lung-cancer
#10
Ying Wu, Hui Lyu, Hongbing Liu, Xuefei Shi, Yong Song, Bolin Liu
Long noncoding RNA (lncRNA) plays pivotal roles in cancer development. To date, only a small number of lncRNAs have been characterized at functional level. Here, we discovered a novel lncRNA termed GAS5-AS1 as a tumor suppressor in non-small cell lung cancer (NSCLC). The expression of GAS5-AS1 in NSCLC tumors was much lower than that in the adjacent normal lung tissues. The reduced GAS5-AS1 was significantly correlated with larger tumors, higher TNM stages, and lymph node metastasis in NSCLC patients. While ectopic expression or specific knockdown of GAS5-AS1 had no effect on proliferation, cell cycle progression, and apoptosis, it dramatically decreased or increased, respectively, NSCLC cell migration and invasion...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27466992/gas5-is-downregulated-in-gastric-cancer-cells-by-promoter-hypermethylation-and-regulates-adriamycin-sensitivity
#11
N Zhang, A-Y Wang, X-K Wang, X-M Sun, H-Z Xue
OBJECTIVE: GAS5 is a tumor suppressive lncRNA that is downregulated in gastric cancer. In this study, we firstly investigated whether epigenetic regulation contributed to GAS5 downregulation and further investigated the role of GAS5 in Adriamycin (ADM) sensitivity in gastric cancer cells. MATERIALS AND METHODS: GAS5 expression in 15 paired gastric cancer tissues and adjacent normal tissues and in gastric cancer cells were detected using qRT-PCR. Methylation-Specific PCR (MSP) was performed with the use of 5-AZA-dC to detect the methylation status of GAS5 promoter...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27445498/lncrna-gas5-is-a-critical-regulator-of-metastasis-phenotype-of-melanoma-cells-and-inhibits-tumor-growth-in-vivo
#12
Long Chen, Huixin Yang, Yanbin Xiao, Xiaoxia Tang, Yuqian Li, Qiaoqiao Han, Junping Fu, Yuye Yang, Yuechun Zhu
The present study intended to demonstrate the effects of long noncoding RNA growth arrest-specific transcript 5 (GAS5) on the migration and invasion of melanoma cells. We first detected the expression of GAS5 among four kinds of melanoma cell lines, followed by constructing GAS5-knocked down and overexpressed stable cells. Next, we evaluated the effects of GAS5 on cell migration and invasion using wound healing and gelatin zymography assays. Finally, melanoma cells with different GAS5 expression were injected into nude mice, and the tumor volumes were recorded and tumor tissues were analyzed after sacrificing the mice...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27432865/long-noncoding-rna-gas5-a-novel-regulator-of-hypertension-induced-vascular-remodeling
#13
Yang-Ning-Zhi Wang, Kun Shan, Mu-Di Yao, Jin Yao, Jia-Jian Wang, Xiang Li, Ban Liu, Yang-Yang Zhang, Yong Ji, Qin Jiang, Biao Yan
Vascular remodeling is an important pathological feature of hypertension, leading to increased vascular resistance and reduced compliance. Endothelial cell (EC) and vascular smooth muscle cell (VSMC) dysfunction is involved in vascular remodeling. Long noncoding RNAs are potential regulators of EC and VSMC function. Herein, we determined whether long noncoding RNA-growth arrest-specific 5 (GAS5) is involved in hypertension-related vascular remodeling. We revealed that GAS5 knockdown aggravated hypertension-induced microvascular dysfunction as shown by increased retinal neovascularization and capillary leakage...
September 2016: Hypertension
https://www.readbyqxmd.com/read/27425867/global-transcriptomic-study-of-atherosclerosis-development-in-rats
#14
Lei Chen, Hong Yao, Ji-Yuan Hui, Sheng-Hao Ding, Yi-Ling Fan, Yao-Hua Pan, Kai-Hong Chen, Jie-Qing Wan, Ji-Yao Jiang
Atherosclerosis is a chronic disease of the arterial wall and a leading cause of death worldwide. Though the pathophysiology of atherosclerotic lesion formation has been studied, we still lack evidence of the global changes in the artery during atherosclerosis. In this report, we induced atherosclerosis in rats and conducted GeneChip analysis on carotid arteries with or without plaque formation. We found that molecular pathways underlying plaque formation in atherosclerosis were related to immune response, angiogenesis, cell proliferation, apoptosis and hypoxic microenvironments, suggesting that the pathophysiology of atherosclerosis is varied...
October 30, 2016: Gene
https://www.readbyqxmd.com/read/27391432/long-non-coding-rnas-novel-prognostic-biomarkers-for-liver-metastases-in-patients-with-early-stage-colorectal-cancer
#15
Hui Kong, Ying Wu, Mengou Zhu, Changwen Zhai, Jing Qian, Xue Gao, Shuyang Wang, Yingyong Hou, Shaohua Lu, Hongguang Zhu
Liver metastasis is the primary cause of death for colorectal cancer (CRC) patients. To investigate the prognostic value of long non-coding RNAs (lncRNAs) on colorectal liver metastases, quantitative reverse-transcriptase PCR (quantitative RT-PCR) was performed on 15 lncRNAs in 51 stage IV CRC with liver metastases and 57 stage I/II CRC specimens. The expression levels of four lncRNAs (GAS5, H19, MEG3 and Yiya) were significantly different between liver metastases and primary tumors of stage IV CRC patients...
July 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27338051/gas5-modulated-autophagy-is-a-mechanism-modulating-cisplatin-sensitivity-in-nsclc-cells
#16
N Zhang, G-Q Yang, X-M Shao, L Wei
OBJECTIVE: In this study, we investigated the association between lncRNA GAS5 and cisplatin (DDP) resistance in NSCLC and further studied the regulative effect of GAS5 on autophagy and DDP resistance. PATIENTS AND METHODS: GAS5 expression in cancerous and adjacent normal tissues from 15 NSCLC patients received neoadjuvant chemotherapy and the following surgery were measured using qRT-PCR analysis. GAS5 gain-and-loss study was performed using A549 and A549/DDP cells as an in-vitro model to investigate the effect of GAS5 on autophagy and cisplatin sensitivity...
June 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27246953/roles-of-long-noncoding-rnas-in-gastric-cancer-and-their-clinical-applications
#17
REVIEW
Weiliang Sun, Yunben Yang, Chunjing Xu, Yi Xie, Junming Guo
PURPOSE: Gastric cancer ranks as the most common cancer in the world. However, the progresses of its diagnosis and treatment are still not satisfactory. The purpose of this study is to summarize the roles of lncRNAs associated with gastric cancer. METHODS: We searched lncRNAs associated with gastric cancer in PubMed. RESULTS: Long noncoding RNAs (lncRNAs), transcripts larger than 200 nucleotides, regulate gene expression at various levels...
November 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27214311/differential-expression-of-glucocorticoid-receptor-noncoding-rna-repressor-gas5-in-autoimmune-and-inflammatory-diseases
#18
T Mayama, A K Marr, T Kino
Glucocorticoids have strong regulatory actions on the immune system and act as potent therapeutic compounds for autoimmune and inflammatory diseases. We previously reported that the long noncoding RNA growth arrest-specific 5 (Gas5), which accumulates inside the cells in response to cellular starvation/growth arrest, functions as a potent repressor of the glucocorticoid receptor (GR) through its RNA "glucocorticoid response element (GRE)". To evaluate potential roles of Gas5 in immune-related disorders, we examined Gas5 RNA levels in various autoimmune, inflammatory, and infectious diseases using the microarray data available in the Gene Expression Omnibus...
August 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27034004/downregulation-of-lncrna-gas5-causes-trastuzumab-resistance-in-breast-cancer
#19
Wentong Li, Limin Zhai, Hui Wang, Chuanliang Liu, Jinbao Zhang, Weijuan Chen, Qun Wei
Therapeutic resistance to trastuzumab caused by dysregulation of long noncoding RNAs (lncRNAs) is a major obstacle to clinical management of HER2-positive breast cancer. To investigate which lncRNAs contribute to trastuzumab resistance, we screened a microarray of lncRNAs involved in the malignant phenotype of trastuzumab-resistant SKBR-3/Tr cells. Expression of the lncRNA GAS5 was decreased in SKBR-3/Tr cells and in breast cancer tissue from trastuzumab-treated patients. Inhibition of GAS5 promoted SKBR-3 cell proliferation, and GAS5 knockdown partially reversed lapatinib-induced inhibition of SKBR-3/Tr cell proliferation...
May 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27001230/differential-expression-of-gas5-in-rapamycin-induced-reversion-of-glucocorticoid-resistance
#20
Marianna Lucafò, Vanessa Bravin, Alberto Tommasini, Stefano Martelossi, Ingrid Rabach, Alessandro Ventura, Giuliana Decorti, Sara De Iudicibus
This study evaluates the association between the long noncoding RNA GAS5 levels and the anti-proliferative effect of the glucocorticoid (GC) methylprednisolone (MP) alone and in combination with rapamycin in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors. The effect of MP, rapamycin, and MP plus rapamycin was determined in 17 healthy donors by labelling metabolically active cells with [methyl-3H] thymidine and the expression levels of GAS5 gene were evaluated by real-time RT-PCR TaqMan analysis...
June 2016: Clinical and Experimental Pharmacology & Physiology
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