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https://www.readbyqxmd.com/read/28101735/urethral-carcinoma-in-situ-recognition-and-management
#1
Ricardo H Berjeaut, Maliza D I Persaud, Nikolai Sopko, Arthur L Burnett
PURPOSE: Urethral carcinoma in situ (CIS) is an uncommon malignancy that is poorly described in the published literature and is often under-recognized in the clinical setting. This short case series reports some challenges associated with the recognition and management of this disease. METHODS: A retrospective chart review was done over a 12-year period of patients presenting with urethral cancer to the Johns Hopkins Hospital. Four patients were identified with CIS of the anterior urethra, and their demographic and clinical data were recorded...
January 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28101348/evans-blue-mediated-white-light-detection-of-non-muscle-invasive-bladder-cancer-a-preclinical-feasibility-and-safety-study-using-a-rat-bladder-urothelial-cell-carcinoma-model
#2
Sanne Elsen, Evelyne Lerut, Frank Van Der Aa, Ben Van Cleynenbreugel, Hendrik Van Poppel, Peter De Witte
Photodynamic diagnosis (PDD) improves the detection of non-muscle-invasive bladder cancer (NMIBC). However, white-light (WL) cystoscopy remains the technique routinely used in urological clinics. A more cost-effective but equally performant alternative to PDD may encompass the use of an intense tumoritropic dye in combination with WL cystoscopy. Using a preclinical setting, we investigated the practical aspects of the use of Evans blue (EB) dye for the possible future detection of NMIBC using WL cystoscopy...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28097268/the-effect-of-office-based-flexible-and-rigid-cystoscopy-on-pain-experience-in-female-patients
#3
Niek F Casteleijn, Jessica L Vriesema, Saskia P Stomps, Olav L W B van Balen, Erik B Cornel
PURPOSE: Rigid and flexible cystoscopies are both routinely used in female patients. Literature is conflicting whether flexible cystoscopy is less painful compared to rigid cystoscopy. The aim of this study was therefore to investigate whether using flexible cystoscopy leads to less discomfort and pain compared to rigid cystoscopy in female patients who underwent first time cystoscopy. MATERIALS AND METHODS: One hundred eighty-nine female patients, who never had undergone cystoscopy, were randomized into 2 groups: 92 patients underwent rigid cystoscopy and 97 patients flexible cystoscopy...
January 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28096925/penile-metastasis-from-primary-transitional-cell-carcinoma-of-the-bladder-sparing-the-urethra
#4
Justin D Oake, Douglas N Drover
Metastatic involvement of the penis is relatively infrequent. Metastasis of transitional cell carcinoma (TCC) is extremely rare. We report a case of bladder TCC with metastases to the penis that spares the urethra - a finding that, to the best of our knowledge, has not been previously reported. Of the documented mechanisms of metastatic transmission to the penis, we suspect the cause was retrograde lymphatic spread. In our case, a 59-year-old male presented to our clinic initially with phimosis and later developed gross hematuria...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28088432/detection-of-upper-tract-urothelial-malignancies-by-computed-tomography-urography-in-patients-referred-for-hematuria-at-a-large-tertiary-referral-center
#5
Clayton W Commander, David C Johnson, Mathew C Raynor, Lauren M Burke, Kathryn E Hacker, Bryan Hoag, Julia R Fielding, Richard C Semelka, Ellie R Lee
OBJECTIVE: To evaluate the age-stratified prevalence of upper tract urothelial malignancies diagnosed on computed tomography urography in a large cohort of patients referred for initial evaluation of hematuria. MATERIALS AND METHODS: A total of 1123 consecutive adults without a history of urothelial cancer underwent initial computed tomography urography for gross hematuria (n = 652), microscopic hematuria (n = 457), or unspecified hematuria (n = 14) at a single institution from October 2006 to October 2012...
January 11, 2017: Urology
https://www.readbyqxmd.com/read/28074325/anticipatory-positive-urine-tests-for-bladder-cancer
#6
Ajay Gopalakrishna, Joseph J Fantony, Thomas A Longo, Richmond Owusu, Wen-Chi Foo, Rajesh Dash, Brian T Denton, Brant A Inman
PURPOSE: The aim of this study was to establish the criteria defining an anticipatory positive test for bladder cancer. METHODS: We reviewed all patients at our institution who underwent urine cytology or UroVysion fluorescence in situ hybridization (FISH) and cystoscopy from 2003 to 2012. Test performance and cancer anticipation was assessed using generalized linear mixed models, mixed-effects proportional hazards models, and cumulative incidence curves using tests performed within 30 days of each other as well as within a lag time of 1 year...
January 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28073192/the-use-of-autologous-platelet-rich-plasma-gel-in-bulbar-and-penile-buccal-mucosa-urethroplasty-preliminary-report-of-our-first-series
#7
Marcello Scarcia, Francesco Paolo Maselli, Giuseppe Cardo, Giuseppe Mario Ludovico
OBJECTIVE: The Buccal Mucosa (BM) UrethroPlasty (UP) is one of the preferred treatments for long or compli-cated urethral strictures. We propose the use of autologous Platelet Rich Plasma gel (aPRPg) in order to enhance to vascularization of BM graft and reduce the fibrous spongy. We report the outcome of our ten cases of bulbar and penile UP and the safety of this technique. Materials and metods: Ten patients underwent to BM UP with use of aPRP gel. Median age was 46. Stricture etiology was idiopathic, failed hypospadias and flogistic...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28070489/acute-disseminated-histoplasmosis-with-atypical-lymphocytosis-in-an-immunocompetent-host
#8
Ayman Elbadawi, Hamdy M A Ahmed, Hussain Adly, Mohamed A Elkhouly, Samar Abohamed, Ann R Falsey
65 year-old-male presented with a one-week history of high grade fever, fatigue and confusion which began abruptly two days after a cystoscopy procedure. Past medical history included pulmonary sarcoidosis diagnosed by mediastinal lymph biopsy, diabetes and hypertension. On admission he was febrile and confused with stable vital signs. Initial workup included negative Head CT and lumbar puncture. Blood work revealed normal metabolic and liver function tests with progressive anemia, thrombocytopenia and atypical lymphocytosis of 15-20%...
2017: IDCases
https://www.readbyqxmd.com/read/28067747/readmission-and-reoperation-after-surgery-for-pelvic-organ-prolapse
#9
Erik D Hokenstad, Amy E Glasgow, Elizabeth B Habermann, John A Occhino
OBJECTIVES: We aimed to determine the rates of readmission and reoperation for patients undergoing surgery for pelvic organ prolapse (POP). METHODS: The American College of Surgeons National Surgical Quality Improvement Program Participant User File was used to select all surgeries performed for POP from 2012 through 2014. The cohort was then reviewed for unplanned readmissions and unplanned reoperations within 30 days of POP surgery. Patient and procedural factors associated with readmission or reoperation were compared using χ analyses and Student t test...
January 6, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28067543/h19-non-coding-rna-in-urine-cells-detects-urothelial-carcinoma-a-pilot-study
#10
Ilan Gielchinsky, Michal Gilon, Rasha Abu-Lail, Imad Matouk, Avraham Hochberg, Ofer N Gofrit, Iddo Z Ben-Dov
CONTEXT: Urothelial carcinoma (UC) is common and highly recurrent. Diagnosis and follow-up involve invasive cystoscopies. OBJECTIVE: To evaluate H19 RNA in urine cells as diagnostic tool for UC. MATERIALS AND METHODS: RT-PCR analysis of urine samples from healthy volunteers and UC patients. RESULTS: H19 RNA was unequivocally detected in the urine of 90.5% of patients and 25.9% of controls. H19 copies were three orders of magnitude higher in patients...
January 9, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28058949/povidone-iodine-sclerotherapy-for-treatment-of-idiopathic-renal-hematuria-in-two-dogs
#11
Lauren B Adelman, Joseph Bartges, Jacqueline C Whittemore
CASE DESCRIPTION A 6-year-old spayed female Great Pyrenees (dog 1) and a 2-year-old spayed female German Shepherd Dog (dog 2) were evaluated because of gross hematuria of 5 and 2 months' duration, respectively. CLINICAL FINDINGS In both dogs, coagulation times were within reference limits, results of aerobic bacterial culture of urine samples were negative, echogenic debris could be seen within the urinary bladder ultrasonographically, and hematuric urine could be seen exiting the right ureterovesicular junction, with grossly normal urine exiting the left ureterovesicular junction, during cystoscopy...
January 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28058716/long-term-follow-up-of-trigonoplasty-antireflux-operation
#12
Farzaneh Sharifiaghdas, Nastaran Mahmoudnejad, Amir H Kashi, Mehdi H Ramezani, Behzad Narouie
BACKGROUND: Open trigonoplasty antireflux operation has been associated with promising results. However, its success in controlling reflux has not been evaluated in the long term. METHODS: All patients who underwent trigonoplasty for vesicoureteral reflux by one surgeon from 2004 to 2014 were included. Preoperative evaluations included direct radionuclide cystography (DRNC) or voiding cystourethrography, urine analysis and culture and abdominal sonography. Urodynamic study and cystoscopy was performed in selected patients...
December 28, 2016: Urologia
https://www.readbyqxmd.com/read/28050795/how-different-cystoscopy-methods-influence-patient-sexual-satisfaction-anxiety-and-depression-levels-a-randomized-prospective-trial
#13
Wojciech Krajewski, Katarzyna Kościelska-Kasprzak, Joanna Rymaszewska, Romuald Zdrojowy
PURPOSE: Bladder cancer (BC) is one of the most common cancers worldwide. BC diagnosis and surveillance is based on cystoscopy (CS). CS impact on patient's depression, anxiety, and sexual satisfaction (SS) is not sufficiently studied. There are no data on patient's comfort with flexible or rigid CS. METHODS: We prospectively evaluated pain perception (PP), depression, anxiety, and SS of 100 male patients who previously underwent at least one rigid CS in our department as surveillance after TURB procedure due to non-muscle-invasive BC and were scheduled for the next CS examination...
January 3, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28049011/fgfr3-tert-and-otx1-as-urinary-biomarker-combination-for-surveillance-of-bladder-cancer-patients-in-a-large-prospective-multicenter-study
#14
Willemien Beukers, Kirstin A van der Keur, Raju Kandimalla, Yvonne Vergouwe, Ewout W Steyerberg, Joost L Boormans, Jorgen B Jensen, José A Lorente, Francisco X Real, Ulrike Segersten, Torben F Orntoft, Nuria Malats, Per-Uno Malmström, Lars Dyrskjot, Ellen C Zwarthoff
PURPOSE: Non-muscle invasive bladder cancer (NMIBC) patients are followed with frequent cystoscopies. In this study FGFR3, TERT and OTX1 are investigated as a diagnostic urinary marker combination during follow-up of patients with primary NMIBC. MATERIAL AND METHODS: In this international multi-center prospective study 977 NMIBC patients were included. Urines (n= 2496) were collected prior to cystoscopy during regular visits. Sensitivity was estimated for detection of concomitant recurrences...
December 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28043766/re-operative-urethroplasty-after-failed-hypospadias-repair-how-prior-surgery-impacts-risk-for-additional-complications
#15
W Snodgrass, N C Bush
PURPOSE: The primary aim of this report was to compare urethroplasty complications for primary distal and proximal repairs with those after 1, 2, 3, and 4 or more re-operations. METHODS: Prospectively collected data on consecutive hypospadias repairs (tubularized incised plate (TIP), inlay, two-stage graft) from 2000 to 2015 were reviewed. Isolated fistula closures were excluded. Extracted information included patient age, meatal location, repair type, primary vs...
December 7, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28034491/a-role-of-multimodality-bladder-preserving-therapy-in-patients-with-muscle-invasive-bladder-cancer-plus-hydronephrosis-with-or-without-pelvic-nodal-involvement
#16
Yun Chiang, Jason Chia-Hsien Cheng, Chao-Yuan Huang, Yu-Chieh Tsai, Chia-Chi Lin, Chih-Hung Hsu, Ann-Lii Cheng, Yeong-Shiau Pu
BACKGROUND/PURPOSE: To retrospectively evaluate the failure patterns of multimodality bladder-preserving therapy in patients with muscle-invasive bladder cancer. METHODS: Patients with muscle-invasive bladder cancer underwent maximal transurethral resection of bladder tumor and induction chemotherapy, followed by concurrent chemoradiotherapy (CCRT). Radiotherapy was given with 45 Gy to the pelvis, 50.4 Gy to the bladder, and 64.8 Gy to the tumor bed. Three protocols of trimodality treatment were used: Protocol A, three cycles of cisplatin and fluorouracil (CF), followed by CCRT with 6 weekly cisplatin; Protocol B, three cycles of weekly paclitaxel plus CF, followed by CCRT with 6 weekly paclitaxel and cisplatin; Protocol C, three cycles of gemcitabine and cisplatin, followed by CCRT with 6 weekly cisplatin...
December 26, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28034440/-urothelial-tumors-in-children
#17
REVIEW
Christine Grapin-Dagorno, Matthieu Peycelon, Pascale Philippe-Chomette, Dominique Berrebi, Alaa El Ghoneimi, Daniel Orbach
Urothelial tumors are very rare in children (to date, only about 150 cases have been reported worlwide). Only 20 % occur before the age of ten. The aim of this study is to specify the clinicopathologic features of urothelial tumor in young patients, which require a slightly different approach to treatment. On the basis of the WHO/ISUP (World Health Organisation/International Society of Urological Pathology) consensus classification report, these lesions are usually low-grade lesions, non invasive, and rarely recurrent...
December 26, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/28018720/registration-of-free-hand-oct-daughter-endoscopy-to-3d-organ-reconstruction
#18
Kristen L Lurie, Roland Angst, Eric J Seibel, Joseph C Liao, Audrey K Ellerbee Bowden
Despite the trend to pair white light endoscopy with secondary image modalities for in vivo characterization of suspicious lesions, challenges remain to co-register such data. We present an algorithm to co-register two different optical imaging modalities as a mother-daughter endoscopy pair. Using white light cystoscopy (mother) and optical coherence tomography (OCT) (daughter) as an example, we developed the first forward-viewing OCT endoscope that fits in the working channel of flexible cystoscopes and demonstrated our algorithm's performance with optical phantom and clinical imaging data...
December 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/28009141/operative-cystoscopy-in-the-neonatal-period
#19
Salvatore Arena, Tiziana Russo, Patrizia Perrone, Carmelo Romeo
Aim of the study is to report the experience in the last three years about endourological treatment of newborns affected by genito- and urinary malformation, implying critical urinary tract dilatation and bladder mass requiring a neonatal operative management. Seven - four males and three female - patients were treated cystoscopically during the neonatal period. Three newborns with a posterior urethral valves (PUV), underwent a successful ablation of PUV. In a male with infected persistent large mullerian duct and subsequent acute urinary retention, a cystoscopically-assisted catheterization was performed...
December 20, 2016: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/27995299/-colovesical-fistulas-an-interdisciplinary-challenge
#20
R Albrecht, T Weirich, O Reichelt, U Settmacher, C Bochmann
BACKGROUND: The aim of treatment of patients with colovesical fistulas should be prompt elimination of the infection and the social burden. We focused on the question whether a minimally invasive surgical approach as a cooperation between surgeons and urologists is possible. This requires effective diagnostics prior to the operation. METHODS: Since 2007 a total of 32 patients with the clinical suspicion of colovesical fistula have undergone extensive preoperative diagnostics...
December 19, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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