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A case control study

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https://www.readbyqxmd.com/read/29909568/association-between-chek2-1100delc-and-breast-cancer-a-systematic-review-and-meta-analysis
#1
REVIEW
Mingming Liang, Yun Zhang, Chenyu Sun, Feras Kamel Rizeq, Min Min, Tingting Shi, Yehuan Sun
INTRODUCTION: The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored. OBJECTIVE: In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate. METHODS: This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls...
June 16, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29909491/blood-levels-of-trace-elements-in-children-with-attention-deficit-hyperactivity-disorder-results-from-a-case-control-study
#2
Rongwang Yang, Yanyi Zhang, Weijia Gao, Nannan Lin, Rong Li, Zhengyan Zhao
Some trace elements may participate in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). This study aimed to investigate the trace element status of zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg), and lead (Pb) in children with ADHD, and to compare them with normal controls. Associations between examined elements and SNAP-IV rating scores of ADHD symptoms were also assessed. Four hundred nineteen children with ADHD (8.8 ± 2.1 years) and 395 matched normal controls (8.9 ± 1.7 years) were recruited in the study...
June 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29909409/the-possible-role-of-gene-variant-coding-nonfunctional-toll-like-receptor-2-in-the-pathogenesis-of-mastocytosis
#3
Bogusław Nedoszytko, Magdalena Lange, Joanna Renke, Marek Niedoszytko, Monika Zabłotna, Jolanta Gleń, Roman Nowicki
BACKGROUND: Data on the genetic predisposition to mastocytosis are scarce. The aim of this work was to study the association of single nucleotide polymorphisms of Toll-like receptor (TLR)-2, TLR-4, and TLR-9 genes in Polish patients with mastocytosis. OBJECTIVES: The study comprised 137 patients with mastocytosis (102 cutaneous [60 children and 42 adults] and 35 systemic cases); 171 disease-free individuals were used as controls. METHOD: The frequency of polymorphisms R753Q (rs5743708) of TLR-2, 896 A>G (rs496790) of TLR-4, and -1237C>T (rs5743836) of TLR-9 genes were determined with the use of the amplification refractory mutation system polymerase chain reaction method...
June 15, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29909406/the-role-of-microrna-608-polymorphism-on-the-susceptibility-and-survival-of-cancer-a-meta-analysis
#4
Zhi-Ming Dai, Jian-Rui Lv, Kang Liu, Xiao-Ming Lei, Wei Li, Gang Wu, Xing-Han Liu, Yu-Xiao Zhu, Qian Hao, Zhi-Jun Dai
The role of rs4919510 polymorphism in microRNA-608 (miR-608) and cancer susceptibility and prognosis remain controversial and debatable. We conducted a meta-analysis of twenty-four eligible publications on the association of rs4919510 polymorphism with cancer risk and/or prognosis. Odds ratios, hazard ratios, and 95% confidence interval were used to investigate the association between this polymorphism and susceptibility, overall survival, and recurrence-free survival of cancer. Overall, eighteen case-control studies and nine cohort studies evaluated the susceptibility and prognostic value of rs4919510 polymorphism in cancer, respectively...
June 16, 2018: Aging
https://www.readbyqxmd.com/read/29909368/long-weekly-working-hours-and-ischaemic-heart-disease-a-follow-up-study-among-145-861-randomly-selected-workers-in-denmark
#5
Harald Hannerz, Ann Dyreborg Larsen, Anne Helene Garde
OBJECTIVES: The aim of the present study was to test if incidences of ischaemic heart disease (IHD) and usage of antihypertensive drugs are independent of weekly working hours (WWH) among full-time employees in Denmark. DESIGN AND PARTICIPANTS: Data on WWH from participants of the Danish labour force surveys, 1999-2013, were linked on an individual level to national registers with data on socioeconomic status (SES), industry, emigrations, redeemed prescriptions, hospital contacts and deaths...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29909305/the-association-of-duration-and-severity-of-disease-with-executive-function-differences-between-drug-na%C3%A3-ve-patients-with-bipolar-and-unipolar-depression
#6
Tao Yang, Guoqing Zhao, Ruizhi Mao, Jia Huang, Xianrong Xu, Yousong Su, Na Zhu, Rubai Zhou, Xiao Lin, Weiping Xia, Fan Wang, Rui Liu, Xing Wang, Zhijia Huang, Yong Wang, Yingyan Hu, Lan Cao, Chengmei Yuan, Zuowei Wang, Raymond W Lam, Jun Chen, Yiru Fang
BACKGROUND: The aims of this study were to investigate the differences in executive function and the relationship with clinical factors between drug-naïve patients with bipolar depression (BDD) and unipolar depression (UPD). METHODS: Drug-naïve patients with BDD, UPD and healthy controls (HC) were recruited (30 cases in each group). All patients were assessed with Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression-17 (HAM-D), and Young Mania Rating Scale (YMRS)...
May 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909298/aerosol-production-during-autopsies-the-risk-of-sawing-in-bone
#7
Jip M E Pluim, Lucas Jimenez-Bou, Reza R R Gerretsen, Arjo J Loeve
When sawing during autopsies on human remains, fine dust is produced, which consists of particles of sizes that may fall within the human respirable range, and can act as vectors for pathogens. The goal of this study was to explore the potential effects of saw blade frequency and saw blade contact load on the number and size of airborne bone particles produced. The methodology involved the use of an oscillating saw with variable saw blade frequencies and different saw blade contact loads on dry human femora...
June 6, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29909218/neuroimaging-in-criminal-trials-and-the-role-of-psychiatrists-expert-witnesses-a-case-study
#8
Georgia Martha Gkotsi, Jacques Gasser, Valérie Moulin
Various neuroscientific techniques are increasingly being used in criminal courts causing a vivid debate on the way that this kind of techniques will and should be used as scientific evidence. The role of experts in this context is important, since it is them that analyse, present, interpret and communicate the results of these techniques to the judges and the jury. In an attempt to contribute to the discussion about the role of the experts in criminal cases where neuroimaging evidence was introduced, we examined twenty seven cases from the US and Europe...
June 13, 2018: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29909179/apoe-%C3%AE%C2%B54-status-in-healthy-older-african-americans-is-associated-with-deficits-in-pattern-separation-and-hippocampal-hyperactivation
#9
Neha Sinha, Chelsie N Berg, Nicholas J Tustison, Ashlee Shaw, Diane Hill, Michael A Yassa, Mark A Gluck
African Americans are 1.4 times more likely than European Americans to carry the apolipoprotein E (APOE) ε4 allele, a risk factor for Alzheimer's disease (AD). However, little is known about the neural correlates of cognitive function in older African Americans and how they relate to genetic risk for AD. In particular, no past study on African Americans has examined the effect of APOE ε4 status on pattern separation-mnemonic discrimination performance and its corresponding neural computations in the hippocampus...
May 26, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29908999/the-roles-of-pai-1-gene-polymorphisms-in-atherosclerotic-diseases-a-systematic-review-and-meta-analysis-involving-149-908-subjects
#10
Yu Liu, Jianxin Cheng, Xiangyi Guo, Jingjing Mo, Beibei Gao, Huiyuan Zhou, Yixin Wu, Zhijuan Li
BACKGROUND: The roles of plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in atherosclerotic diseases were intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between PAI-1 genetic variations and atherosclerosis. METHODS: Eligible studies were searched in PubMed, Medline, Embase and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess relationship between PAI-1 polymorphisms and atherosclerotic diseases...
June 14, 2018: Gene
https://www.readbyqxmd.com/read/29908950/low-transcriptional-activity-of-pon2-in-recurrent-abortion-a-novel-therapeutic-agent
#11
Levent Dikbas, Riza Dur, İsmail Hakkı Tas, Ömer Erkan Yapça, Neslihan Dikbas
OBJECTIVE: Oxidative stress has been reported to be associated with various pregnancy complications and to play key roles in many of them. An inadequate level of antioxidant defense may eventually lead to an early pregnancy loss. There is a lack of information about the roles of the PON2 and PON3 enzymes in the etiology of the cases of unexplained recurrent abortus. The aim of our study is to determine and present the data regarding the roles of these enzymes for the first time. MATERIALS AND METHODS: We measured the transcriptional levels of the PON2 and PON3 enzymes in the curettage materials obtained from the patients with unexplained recurrent abortus (n=25) and compared the results with those measured in the abortus materials from healthy pregnant women (n=50) who had undergone a voluntary abortion...
June 14, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29908928/a-novel-muscle-transfer-for-independent-digital-control-of-a-myoelectric-prosthesis-the-starfish-procedure
#12
R Glenn Gaston, John W Bracey, Mark A Tait, Bryan J Loeffler
Control of independent digital flexion and extension has remained an elusive goal in myoelectric prosthetics for upper extremity amputees. We first performed a cadaver study to determine the feasibility of transferring the interossei muscles for each digit to the dorsum of the hand without damaging the neurovascular pedicles. Once this capability was ensured, a clinical case was performed transferring the interossei of the middle and ring fingers to the dorsum of the hand where they could serve as a myoelectric signal for a partial hand amputee to allow individual digital control with a myoelectric prosthesis...
June 13, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29908912/oral-n-acetylcysteine-in-the-treatment-of-obsessive-compulsive-disorder-a-systematic-review-of-the-clinical-evidence
#13
REVIEW
José Paulo Couto, Ricardo Moreira
Obsessive-compulsive disorder (OCD) is characterized by the presence of obsessions and/or compulsions. It is a leading cause of morbidity worldwide, as it can interfere with all aspects of life. Despite the adequate treatment trials, half of patients preserve residual or impairing symptoms and selective serotonin reuptake inhibitors (SSRIs) are not free from adverse side effects. This work aims to systematically review the current evidence available concerning the efficacy of N-acetylcysteine (NAC) in the treatment of OCD...
June 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29908819/association-of-25-hydroxyvitamin-d-levels-and-cutaneous-melanoma-a-nested-case-control-study-of-the-women-s-health-initiative-observation-study
#14
Gina P Kwon, Christina S Gamba, Marcia L Stefanick, Susan M Swetter, Shufeng Li, Run Zhang Shi, Christina A Clarke, David Feldman, Amy E Millen, Catherine Messina, James M Shikany, JoAnn E Manson, Rowan T Chlebowski, Jean Y Tang
No abstract text is available yet for this article.
July 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29908670/safety-and-efficacy-of-upadacitinib-in-patients-with-active-rheumatoid-arthritis-refractory-to-biologic-disease-modifying-anti-rheumatic-drugs-select-beyond-a-double-blind-randomised-controlled-phase-3-trial
#15
Mark C Genovese, Roy Fleischmann, Bernard Combe, Stephen Hall, Andrea Rubbert-Roth, Ying Zhang, Yijie Zhou, Mohamed-Eslam F Mohamed, Sebastian Meerwein, Aileen L Pangan
BACKGROUND: Phase 2 studies with upadacitinib, a selective Janus kinase 1 (JAK1) inhibitor, have shown safety and efficacy in the treatment of patients with active rheumatoid arthritis. We did this study to further assess the safety and efficacy of upadacitinib in patients with an inadequate response to biologic disease-modifying anti-rheumatic drugs (bDMARDs). METHODS: We did this double-blind, randomised controlled phase 3 trial at 153 sites in 26 countries. Patients were aged 18 years or older, had active rheumatoid arthritis and previous inadequate response or intolerance to bDMARDs, and were receiving concomitant background conventional synthetic DMARDS (csDMARDs)...
June 12, 2018: Lancet
https://www.readbyqxmd.com/read/29908517/high-sensitive-cardiac-troponin-hs-tnt-levels-in-sudden-deaths-related-to-atherosclerotic-coronary-artery-disease
#16
Tim Beausire, Mohamed Faouzi, Cristian Palmiere, Tony Fracasso, Katarzyna Michaud
INTRODUCTION: Ischemic heart disease (IHD) related to atherosclerotic coronary artery disease (CAD) is one of the most prevalent causes of death in Europe. Postmortem evaluation of IHD remains a challenge because of possible non-specific autopsy finding in some autopsy cases, especially in early myocardial ischemia. High-sensitive cardiac troponin T (hs-TnT) is used today in clinical practice as the "gold standard" to diagnose the myocardial ischemia, and might also be applied as an ancillary tool for post-mortem evaluation...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29908474/early-warnings-for-suicide-attempt-among-chinese-rural-population
#17
Juncheng Lyu, Yingying Wang, Hong Shi, Jie Zhang
OBJECTIVE: This study was to explore the main influencing factors of attempted suicide and establish an early warning model, so as to put forward prevention strategies for attempted suicide. METHOD: Data came from a large-scale case-control epidemiological survey. A sample of 659 serious suicide attempters was randomly recruited from 13 rural counties in China. Each case was matched by a community control for gender, age, and residence location. Face to face interviews were conducted for all the cases and controls with the same structured questionnaire...
June 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29908384/assessing-depression-severity-with-a-self-rated-vs-rater-administered-instrument-in-patients-with-epilepsy
#18
Shirin Jamal-Omidi, Christine Collins, Erin Fulchiero, Hongyan Liu, Kari Colon-Zimmermann, Edna Fuentes-Casiano, Curtis Tatsuoka, Kristin A Cassidy, Samden Lhatoo, Martha Sajatovic
RATIONALE: Up to 30-50% of individuals with epilepsy have depressive symptoms, which often complicate seizure management and reduce overall quality of life. To identify and manage depressive symptoms appropriately, clinicians need standardized instruments that can accurately identify and monitor those with clinically significant depression. The self-reported 9-item Patient Health Questionnaire (PHQ-9) has been used relatively widely to screen and monitor depression in epilepsy. The rater-administered Montgomery-Asberg Depression Rating Scale (MADRS) is a rater-administered instrument widely used in depression treatment trials but less widely applied in epilepsy...
June 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29908378/vitamin-d-deficiency-and-lower-urinary-tract-symptoms-in-women
#19
H Aydogmus, U S Demirdal
OBJECTIVE: The association of vitamin D deficiency and pelvic floor dysfunction has been examined by numerous studies. Lower urinary tract symptoms (LUTS) associated with bladder filling and voiding functions are common in both sexes. A recent study reports a higher incidence of LTUS in men over 50 years old with vitamin D deficiency. The aim of the study is to investigate whether there is a difference in the Lower Urinary Tract Symptoms frequency between women with vitamin D deficiency and the control group or not...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908355/medial-acetabular-wall-breach-in-total-hip-arthroplasty-is-full-weight-bearing-possible
#20
Filippo Mandelli, Simon Tiziani, Jürgen Schmitt, Clément M L Werner, Hans-Peter Simmen, Georg Osterhoff
BACKGROUND: A breach of the medial acetabular wall is a phenomenon seen frequently due to over-reaming during total hip arthroplasty (THA). The consequences of this issue are not fully understood particularly in cementless THA. A retrospective study was performed to answer whether: 1) immediate postoperative full-weight bearing in the presence of a medial acetabular wall breach after THA results in more short-term revisions of the acetabular component, 2) increases the risk for migration of the acetabular component? HYPOTHESIS: Immediate full-weight bearing in the presence of a medial breach is not associated with an increased likelihood for acetabular-related revision surgery or migration of the cup...
June 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
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