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Donatella Del Sindaco, Maria Denitza Tinti, Giovanni Pulignano, Stefano Tolone, Giovanni Minardi, Massimo Uguccioni, Antonio Lax
In the setting of heart failure (HF) pharmacotherapy demonstrates a quantifiable improvement in exercise tolerance also in HF with preserved ejection fraction (HFpEF). For patients with HFpEF, often older, with higher prevalence of hypertension, diabetes mellitus, atrial fibrillation and other comorbidities, endpoints such as quality of life and functional capacity may be more clinically relevant. However several study show as the use of ACE-I and B-blocker were lesser than expected. Beta-blocker therapy is the keystone of pharmacotherapy of HF patients and exercise training is the essential core of rehabilitation programs, it is important to elucidate the relationship between these therapies...
June 22, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Martina Rafanelli, Andrea Ungar
The prevalence of hypertension increases with the age. Diagnostic criteria are the same as for the young, but in older adults isolated systolic hypertension is more frequent, due to loss of vascular compliance. Blood pressure should be measured on both sides in the seated position, moreover in the supine and upright position to detect orthostatic hypotension. Ambulatory blood pressure monitoring is useful to detect white coat hypertension and masked hypertension, to tailor the treatment and search for diurnal and nocturnal blood pressure pattern abnormalities...
June 22, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Flavio D'Ascenzi, Matteo Cameli, Marco M Ciccone, Maria Maiello, Pietro A Modesti, Sergio Mondillo, Maria L Muiesan, Pietro Scicchitano, Salvatore Novo, Pasquale Palmiero, Pier S Saba, Roberto Pedrinelli
Atrial fibrillation is the most common clinically significant arrhythmia observed both in the general population and in competitive athletes. The most important risk factors are all preventable by regular physical activity. However, although the benefits of moderate physical activity in controlling cardiovascular risk factors and decreasing the risk of atrial fibrillation have been extensively proved, concerns have arisen about the potential negative effects of vigorous exercise, particularly in endurance athletes...
December 2015: Journal of Cardiovascular Medicine
Roberto Pedrinelli, Piercarlo Ballo, Cesare Fiorentini, Silvia Denti, Maurizio Galderisi, Antonello Ganau, Giuseppe Germanò, Pasquale Innelli, Anna Paini, Stefano Perlini, Massimo Salvetti, Valerio Zacà
History of hypertension is a frequent finding in patients with acute myocardial infarction (AMI) and its recurring association with female sex, diabetes, older age, less frequent smoking and more frequent vascular comorbidities composes a risk profile quite distinctive from the normotensive ischemic counterpart.Antecedent hypertension associates with higher rates of death and morbid events both during the early and long-term course of AMI, particularly if complicated by left ventricular dysfunction and/or congestive heart failure...
March 2012: Journal of Cardiovascular Medicine
Alessandro Sciarra
G.G. è un paziente di 62 anni, in condizioni generali discrete, che giunge alla nostra osservazione per la presenza di sintomi urinari del basso tratto urinario, International Prostate Symptom Score (IPSS) pari a 16. Anamnesi familiare negativa per carcinoma prostatico. Il paziente esegue terapia con calcio antagonista per ipertensione arteriosa. Ha subito un intervento di colecistectomia. Il paziente riferiva inoltre una qualità di vita negativamente influenzata da sintomi minzionali irritativi che lo portavano ad alzarsi più di 3 volte a notte per urinare ed una pollachiuria diurna ogni 3 ore...
October 2011: Urologia
Fabio Angeli, Enrica Angeli, Claudio Cavallini, Giuseppe Ambrosio, Giovanni Mazzotta, Gianpaolo Reboldi, Paolo Verdecchia
BACKGROUND: Although repolarization abnormalities on ECG are frequent in post-menopausal hypertensive women, their prognostic value in these women is uncertain. METHODS: We analyzed 908 hypertensive post-menopausal women consecutively included in the PIUMA (Progetto Ipertensione Umbria Monitoraggio Ambulatoriale) study. The median duration of follow-up was 8.6 years (range: 1-21). All women were untreated at entry. Drug treatment during follow-up was adjusted to single individuals...
October 2010: Maturitas
Fabio Angeli, Enrica Angeli, Giuseppe Ambrosio, Giovanni Mazzotta, Gianpaolo Reboldi, Paolo Verdecchia
OBJECTIVE: High white blood cell and neutrophil counts identify patients at increased cardiovascular risk in various clinical settings. However, the prognostic value of white blood cell and neutrophil counts in hypertensive postmenopausal women is unknown. We tested the independent prognostic value of total white blood cell and neutrophil counts for cardiovascular events in hypertensive postmenopausal women. METHODS: We examined 298 initially untreated postmenopausal women with essential hypertension who were part of Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA)...
April 2010: Obstetrics and Gynecology
Paolo Verdecchia, Fabio Angeli, Mariagrazia Sardone, Claudia Borgioni, Marta Garofoli, Gianpaolo Reboldi
OBJECTIVES: Although the prognostic value of the day-night blood pressure (BP) changes is well established, the most appropriate method for definition of daytime and nighttime BP is still undefined. In a recent guidelines document of the European Society of Hypertension, there is no clear position in favor of one definition over other. METHODS: In the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulariale study, we analyzed the prognostic impact of the day-night BP changes by using three widely used different definitions of day and night (large fixed-clock intervals, narrow fixed-clock intervals, diary) in 2934 initially untreated participants with essential hypertension...
June 2008: Blood Pressure Monitoring
Giuseppe Mancia, Guy De Backer, Anna Dominiczak, Renata Cifkova, Robert Fagard, Giuseppe Germanò, Guido Grassi, Anthony M Heagerty, Sverre E Kjeldsen, Stephane Laurent, Krzysztof Narkiewicz, Luis Ruilope, Andrzej Rynkiewicz, Roland E Schmieder, Harry A J Struijker Boudier, Alberto Zanchetti, Alec Vahanian, John Camm, Raffaele De Caterina, Veronica Dean, Kenneth Dickstein, Gerasimos Filippatos, Christian Funck-Brentano, Irene Hellemans, Steen Dalby Kristensen, Keith McGregor, Udo Sechtem, Sigmund Silber, Michal Tendera, Petr Widimsky, José Luis Zamorano, Serap Erdine, Wolfgang Kiowski, Enrico Agabiti-Rosei, Ettore Ambrosioni, Lars H Lindholm, Athanasios Manolis, Peter M Nilsson, Josep Redon, Margus Viigimaa, , et al.
No abstract text is available yet for this article.
July 2007: Giornale Italiano di Cardiologia
Giuseppe Schillaci, Matteo Pirro, Giacomo Pucci, Tiziana Ronti, Gaetano Vaudo, Massimo R Mannarino, Carlo Porcellati, Elmo Mannarino
BACKGROUND: Chronic low-grade inflammation may contribute to vascular injury and atherogenesis, and has been described in association to high blood pressure (BP). However, as yet the prognostic significance of white blood cell (WBC) count in the setting of uncomplicated hypertension has not been investigated. METHODS: In the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study, 1617 white patients with essential hypertension (aged 49 +/- 12 years, 55% men) without prevalent cardiovascular or renal disease underwent off-treatment baseline clinical evaluation and were then followed up for 11 years (average 4...
April 2007: American Journal of Hypertension
Giovanni de Simone, Giuseppe Schillaci, Marcello Chinali, Fabio Angeli, Gian Paolo Reboldi, Paolo Verdecchia
OBJECTIVES: Blood pressure (BP) measured in the office is usually higher than the average ambulatory BP, a difference generally taken as an estimate of the white-coat effect. This study was designed to assess whether such a difference is associated with impairment of the conduit arterial system. METHODS: We calculated the difference between office and average daytime peak systolic blood pressure (DeltaSBP) in 2778 hypertensive participants (1240 women) of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale cohort...
April 2007: Journal of Hypertension
M Dalla Vestra, G Pozza, A Mosca, V Grazioli, A Lapolla, P Fioretto, G Crepaldi
Microalbuminuria and hypertension are risk factors for diabetic nephropathy in Type 2 diabetic patients. Recent data suggest that blockade of the renin-angiotensin system slows the progression of diabetic nephropathy; in contrast, the results on the renoprotective effect of calcium channel antagonists are conflicting. We evaluated the effectiveness of lercanidipine, in comparison with ramipril, on the reduction in albumin excretion rate (AER) and blood pressure in mild-to-moderate hypertensive patients with Type 2 diabetes and persistent microalbuminuria...
October 2004: Diabetes, Nutrition & Metabolism
Giovanni de Simone, Richard B Devereux, Aldo P Maggioni, Massimo Gorini, Oreste de Divitiis, Paolo Verdecchia
BACKGROUND: Different methods of normalizing left ventricular (LV) mass for body size identify generally similar relative risks of adverse cardiovascular outcome but with variable prevalences of LV hypertrophy (H). Preliminary results from a population with high prevalence of obesity suggest that the population attributable-risk percent (PAR%) of LVH is substantially higher when LV mass is normalized for allometric power of height. METHODS: We calculated the PAR% of LVH by different definitions in the cohort of the MAssa Ventricolare sinistra nell' Ipertensione (MAVI) study (n = 1019, 62% women), a population with low prevalence of obesity (22%, with only 3% and 0...
October 2005: American Journal of Hypertension
Giuseppe Mancia, Achille C Pessina, Bruno Trimarco, Guido Grassi et al.
OBJECTIVE: It is well established that adequate blood pressure (BP) control characterizes only a fraction of treated hypertensive patients. Few reports are available on BP control in relation to the cardiovascular risk profile in patients followed by specialist physicians. METHODS: We evaluated the cardiovascular risk profile (according to recent ESH/ESC Guidelines), antihypertensive drug treatment and systolic and diastolic blood pressure values (SBP/DBP) by semi-automatic BP monitoring in 2775 hypertensive patients, aged 60...
December 2004: Journal of Hypertension
P Verdecchia, F Angeli, R Gattobigio, M Guerrieri, G Benemio, C Porcellati
Systolic blood pressure (SBP) is an important determinant of the development and regression of left ventricular hypertrophy (LVH) in hypertensive humans. However, comparative assessments with other BP components are scarce and generally limited in size. As part of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA), 743 hypertensive subjects underwent echocardiography and 24-h ambulatory BP monitoring before and after an average of 3.9 years of treatment. The changes in left ventricular mass showed a significant direct association with the changes in 24-h SBP (r=0...
December 2004: Journal of Human Hypertension
Giuseppe Schillaci, Leonella Pasqualini, Paolo Verdecchia, Gaetano Vaudo, Simona Marchesi, Carlo Porcellati, Giovanni de Simone, Elmo Mannarino
OBJECTIVES: We sought to assess the prognostic value of alterations in left ventricular (LV) diastolic function in patients with essential hypertension. BACKGROUND: Alterations in LV diastolic function are frequent in patients with hypertension, even in the absence of LV hypertrophy, but their prognostic significance has never been investigated. METHODS: In the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study, we followed, for up to 11 years (mean: 4...
June 19, 2002: Journal of the American College of Cardiology
G Schillaci, G Reboldi, P Verdecchia
BACKGROUND: Determination of serum creatinine concentration is recommended in all patients with hypertension as a marker of target organ damage. However, the possibility that creatinine values within the reference range might contribute to stratification of cardiovascular risk in essential hypertension has never been tested. PATIENTS AND METHODS: In the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale Study, for up to 11 years (mean, 4 years) we followed up 1829 white patients with hypertension (mean +/- SD age, 51 +/- 12 years; 53% men; office blood pressure, 157/98 mm Hg) free of cardiovascular events and with normal pretreatment creatinine levels (men, <136 micromol/L [<1...
March 26, 2001: Archives of Internal Medicine
P Verdecchia, G Schillaci, G P Reboldi, N Sacchi, B Bruni, G Benemio, C Porcellati
BACKGROUND: The long-term effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on ambulatory blood pressure and cardiac performance have never been examined comparatively. OBJECTIVE: We compared losartan and enalapril in their long-term effects on office and ambulatory blood pressure, cardiac structure and function, and routine biochemical tests. DESIGN: In the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study, 22 hypertensive subjects were studied with ambulatory blood pressure monitoring and echocardiography before and after an average of 3...
June 2000: Blood Pressure Monitoring
P Verdecchia, G Schillaci, G Reboldi, C Borgioni, A Ciucci, C Porcellati
We conducted a retrospective analysis of all subjects with essential hypertension and Type 2 diabetes mellitus enrolled in the PIUMA (Progetto Ipertensione Umbria Monitoraggio Ambulatoriale) registry, in order to evaluate whether the use of calcium antagonists is associated with an increase in cardiovascular risk in these subjects. One hundred and sixty-four consecutive subjects with no previous cardiovascular morbid events and coexistence of essential hypertension and Type 2 diabetes mellitus were studied before therapy and followed for up to 12 years (mean 5)...
August 1999: Diabetes, Nutrition & Metabolism
Verdecchia, Schillaci, Borgioni, Ciucci, Gattobigio, Guerrieri, Comparato, Benemio, Porcellati
BACKGROUND: In a previous analysis of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale we found a higher rate of cardiovascular morbid events among hypertensive nondippers than we did among dippers (5.86 versus 1.18 events per 100 person-years, P = 0.0002) for women, whereas the difference between the two groups was smaller and not statistically significant for men (4.15 versus 2.48 events per 100 person-years). These differences held in a multivariate analysis after adjustment for several confounders including average 24 h ambulatory blood pressure...
December 1997: Blood Pressure Monitoring
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