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https://www.readbyqxmd.com/read/29458206/mucoadhesive-self-emulsifying-delivery-systems-for-ocular-administration-of-econazole
#1
Ibrahim A Elbahwy, Noemi Lupo, Hany M Ibrahim, Hatem R Ismael, Alaa A Kasem, Cagri Caliskan, Barbara Matuszczak, Andreas Bernkop-Schnürch
AIM: Development of mucoadhesive self-emulsifying drug delivery systems (SEDDS) providing a prolonged ocular residence time for poorly soluble active pharmaceutical ingredient. METHODS: L-Cysteine was covalently linked to 6-mercaptonicotinamide. The obtained ligand, Cysteine-6- mercaptonicotinamide (Cys-6-MNA) was attached to Eudragit® L100-55 via a carbodiimide mediated amide bond formation. The resulting entirely S-protected thiolated Eudragit® L100-55 was characterized regarding the degree of modification as well as stability toward oxidation in the presence of strong oxidizing agent (H2 O2 )...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458200/influence-of-treatment-modality-on-morbidity-and-mortality-in-periprosthetic-femoral-fracture-a-comparative-study-of-71-fractures-treated-by-internal-fixation-or-femoral-implant-revision
#2
S Cohen, X Flecher, S Parratte, M Ollivier, J N Argenson
INTRODUCTION: The incidence of periprosthetic femoral fracture is constantly increasing, with high associated morbidity and mortality. Surgical treatment is guided by the Vancouver classification, but the influence of type of treatment on morbidity and mortality has been little analyzed. The theoretic advantage of implant revision over internal fixation is that it should allow earlier weight-bearing, although the impact of this on morbidity and mortality and autonomy has not been demonstrated...
February 16, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29458144/disruption-of-peroxisome-function-leads-to-metabolic-stress-mtor-inhibition-and-lethality-in-liver-cancer-cells
#3
Mengjiao Cai, Xiao Sun, Wenchao Wang, Zhusheng Lian, Ping Wu, Suxia Han, Huan Chen, Pumin Zhang
Peroxisome houses a large number of enzymes involved in lipid and phytochemical oxidation as well as synthesis of bile acid and other specialized lipids. Peroxisome resident enzymes are imported into the organelle via a conserved cargo transport system composed of many peroxins, protein factors essential for the biogenesis of peroxisome. Among the peroxins, PEX5 plays a transporter role, and PEX2, 10, and 12 are thought to form a complex that functions as an E3 ubiquitin ligase to help recycle PEX5 in an ubiquitin modification-dependent process...
February 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29457983/antimycobacterial-effect-of-ifng-interferon-gamma-induced-autophagy-is-dependent-on-the-hmox1-heme-oxygenase-1-mediated-increase-in-the-intracellular-calcium-levels-and-modulation-of-ppp3-calcineurin-tfeb-transcription-factor-eb-axis
#4
Nisha Singh, Pallavi Kansal, Zeeshan Ahmad, Naveen Baid, Hariom Kushwaha, Neeraj Khatri, Ashwani Kumar
IFNG (interferon gamma)-induced autophagy plays an important role in the elimination of intracellular pathogens, such as Mycobacterium tuberculosis (Mtb). However, the signaling cascade that leads to the increase in autophagy flux in response to IFNG is poorly defined. Here, we demonstrate that HMOX1 (heme oxygenase 1)-generated carbon monoxide (CO) is required for the induction of autophagy and killing of Mtb residing in macrophages in response to immunomodulation by IFNG. Interestingly, IFNG exposure of macrophages induces an increase in intracellular calcium levels that is dependent on HMOX1 generated CO...
February 19, 2018: Autophagy
https://www.readbyqxmd.com/read/29457982/discovery-of-gdc-0853-a-potent-selective-and-non-covalent-bruton-s-tyrosine-kinase-inhibitor-in-early-clinical-development
#5
James J Crawford, Adam R Johnson, Dinah L Misner, Lisa D Belmont, Georgette M Castanedo, Regina Choy, Melis Coraggio, Liming Dong, Charles Eigenbrot, Rebecca Erickson, Nico Ghilardi, Jonathan Hau, Arna Katewa, Pawan Bir Kohli, Wendy Lee, Joseph W Lubach, Brent S McKenzie, Daniel Fred Ortwine, Leah Schutt, Suzanne Tay, Binqing Wei, Karin Reif, Lichuan Liu, Harvey Wong, Wendy B Young
Btk is a non-receptor cytoplasmic tyrosine kinase involved in B-cell and myeloid cell activation, downstream of B-cell and Fcγ receptors, respectively. Pre-clinical studies have indicated that inhibition of Btk activity might offer a potential therapy in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Here we disclose the discovery and pre-clinical characterization of a potent, selective, and non-covalent Btk inhibitor currently in clinical development. GDC-0853 (29) suppresses B cell- and myeloid cell-mediated components of disease, and demonstrates dose-dependent activity in an in vivo rat model of inflammatory arthritis...
February 19, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29457928/an-atraumatic-retractor-for-interdisciplinary-use-in-conventional-laparoscopy-and-robotic-surgery
#6
Ibrahim Alkatout
BACKGROUND: The removal of obstacles from the surgical field is a crucial aspect of any procedure in gynecological, urological or visceral laparoscopic surgery. Reliable instruments and skilled assistance are essential for the smooth execution of procedures. Blunt forceps are commonly used to keep tissue away from the operating field. The range of existing instruments has been enhanced by the introduction of laparoscopic retractors. However, no laparoscopic retractor can be used without causing tissue damage...
February 19, 2018: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29457871/a-qtl-on-chromosome-1-modulates-inter-male-aggression-in-mice
#7
Anna Delprato, Brice Bonheur, Marie-Paule Algéo, Alba Murillo, Esha Dhawan, Lu Lu, Robert W Williams, Wim E Crusio
Aggression between male conspecifics is a complex social behavior that is likely modulated by multiple gene variants. In this study the BXD recombinant inbred mouse strains (RIS) were used to map quantitative trait loci (QTLs) underlying behaviors associated with intermale aggression. Four hundred and fifty-seven males from 55 strains (including the parentals) were observed at an age of 13 +/- 1 week in a resident-intruder test following 10 days of isolation. Attack latency was measured directly within a 10 minute time period and the test was repeated 24 hours later...
February 19, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29457860/controlling-the-outgrowth-and-functions-of-neural-stem-cells-the-effect-of-surface-topography
#8
REVIEW
Chara Simitzi, Kanelina Karali, Anthi Ranella, Emmanuel Stratakis
Neural stem cells (NSCs) are self-renewing cells that generate the major cell types of the central nervous system, namely neurons, astrocytes and oligodendrocytes, during embryonic development and in the adult brain. NSCs reside in a complex niche where they are exposed to a plethora of signals, including both soluble and physical signals such as compressive and shear stresses, but also discontinuities and differences in morphology of the extracellular environment, termed as topographical features. Different approaches that incorporate artificial micro- and nano-scale surface topographical features have been developed aiming to recapitulate the in vivo NSC niche discontinuities and features, particularly for in vitro studies...
February 19, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29457554/complexity-of-articulation-planning-in-apraxia-of-speech-the-limits-of-phoneme-based-approaches
#9
Wolfram Ziegler
This report presents evidence suggesting that the phoneme-based approach taken by Romani, Galuzzi, Guariglia, and Goslin (Comparing phoneme frequency, age of acquisition, and loss in aphasia: Implications for phonological universals. Cognitive Neuropsychology, this issue) falls short of capturing the complexity of articulation planning in patients with apraxia of speech. Empirical and modelling data are reported to demonstrate that the apraxic pathomechanism resides in the hierarchical architecture of phonological words rather than in the context-independent properties of phonemes...
October 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29457512/perceived-diet-and-exercise-behaviors-among-social-network-members-with-personal-lifestyle-habits-of-public-housing-residents
#10
Kimberly A Gudzune, Jennifer Peyton, Craig Evan Pollack, J Hunter Young, David M Levine, Carl A Latkin, Jeanne M Clark
Our objective was to characterize the relationship between public housing residents' diet/exercise habits with similar behaviors among their social network. We conducted a cross-sectional survey of randomly selected households in Baltimore, Maryland, from August 2014 to August 2015. Adult heads of household completed questions on diet, exercise, and perceived habits among network members. Our dependent variables were high added sugar intake (≥39.9 teaspoons/day), high fruit/vegetable intake (≥6.1 servings/day), and being physically active (≥moderately activity)...
February 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29457361/cognitive-function-and-unsafe-driving-acts-during-an-on-road-test-among-community-dwelling-older-adults-with-cognitive-impairments
#11
Ryo Hotta, Hyuma Makizako, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Keitaro Makino, Hiroyuki Shimada
AIM: To examine the relationship between cognitive function and unsafe driving acts among community-dwelling older adults with cognitive impairments. METHODS: Participants (n = 160) were older residents of Obu, Japan, aged ≥65 years with cognitive impairments. They regularly drove and were assessed for the number of unsafe driving acts without adequate verification during an on-road test. We also evaluated cognitive function (attention, executive function and processing speed)...
February 19, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29457297/the-impact-of-bacteriophages-on-phyllosphere-bacterial-abundance-and-composition
#12
Norma M Morella, Annika L Gomez, Grant Wang, Michelle S Leung, Britt Koskella
Interactions between bacteria and bacteriophage viruses (phages) are known to influence pathogen growth and virulence, microbial diversity, and even biogeochemical cycling. Lytic phages in particular infect and lyse their host cells, and can therefore have significant effects on cell densities as well as competitive dynamics within microbial communities. Despite the known impacts of lytic phages on the ecology and evolution of bacteria in free-living communities, little is known about the role of lytic phages in host-associated microbiomes...
February 19, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29457248/duty-hours-restriction-for-our-surgical-trainees-an-ethical-obligation-or-a-bad-idea
#13
REVIEW
Christopher A Adin, Callie A Fogle, Steven L Marks
To ensure patient safety and protect the well-being of interns and residents, the Accreditation Council for Graduate Medical Education (ACGME) issued guidelines in 2003 limiting the working hours of physician trainees. Although many supported the goals of the ACGME, institutions struggled to restructure their programs and hire staff required by this unfunded mandate. Numerous studies have analyzed the effects of duty hours restrictions on patient outcomes and physician training over the past 15 years. Most agree that duty hours restrictions improved well-being of house officers, but these improvements came at the expense of continuity, and patient hand-offs led to medical errors...
February 19, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29457230/impact-of-hand-eczema-on-quality-of-life-metropolitan-versus-non-metropolitan-areas
#14
Line B Nørreslet, Tove Agner, Jennifer A Sørensen, Niels E Ebbehøj, Jens P Bonde, Maja H Fisker
BACKGROUND: An inverse relationship between disease severity and health-related quality of life (HR-QoL) in patients with hand eczema is well established, but modifying effects of demographic variables have been less well studied. OBJECTIVE: To identify the influence of metropolitan versus non-metropolitan residence on the relationship between disease severity and HR-QoL in patients with occupational hand eczema. METHODS: The city of Copenhagen and the rest of Zealand were defined as metropolitan and non-metropolitan areas, respectively...
February 19, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29456914/is-cervical-bracing-necessary-after-one-and-two-level-instrumented-anterior-cervical-discectomy-and-fusion-a-prospective-randomized-study
#15
Samuel C Overley, Robert K Merrill, Evan O Baird, Joshua J Meaike, Samuel K Cho, Andrew C Hecht, Sheeraz A Qureshi
Study Design: Prospective randomized control trial. Objective: To investigate the role of cervical collars in postoperative care following 1- and 2-level instrumented anterior cervical discectomy and fusion (ACDF). Methods: The Cervical Spine Research Society Resident Fellow Grant funded this project. Fifty consecutive patients undergoing 1- or 2-level ACDF surgery were randomized into groups receiving either no brace or a cervical brace for 6 weeks postoperatively...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456855/metformin-and-aspirin-treatment-could-lead-to-an-improved-survival-rate-for-type-2-diabetic-patients-with-stage-ii-and-iii-colorectal-adenocarcinoma-relative-to-non-diabetic-patients
#16
Ariella De Monte, Davide Brunetti, Luigi Cattin, Francesca Lavanda, Erica Naibo, Maria Malagoli, Giorgio Stanta, Serena Bonin
Metformin, the drug of choice in the treatment of type 2 diabetes mellitus (DM2), in addition to aspirin (ASA), the drug prescribed for cardioprotection of diabetic and non-diabetic patients, have an inhibitory effect on cancer cell survival. The present population-based study conducted in the province of Trieste (Italy), aimed to investigate the prevalence of DM2 in patients with colorectal adenocarcinoma (CRC) and survival for CRC in diabetic and nondiabetic patients. All permanent residents diagnosed with a CRC between 2004 and 2007 were ascertained through the regional health information system...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456823/health-hazards-related-to-soba-sewage-treatment-plant-sudan
#17
Rasha Osman Abdelwahab Abdelmoneim, Ranien Mohamed El Mortada Mahi Eldin Mahdi, Rawia Moawia Elamin Elahmer, Rogaya Adel Derar Elansary, Safaa Elsafi Widaa Mohamed, Said Hashim Ahmed Abdelgader, Sakina Salah Abbasher Ahmed, Sally Mohamed Alfatih Abdalrhman
The aim of this study was to determine the health hazards acquired by the residents nearby Soba sewage treatment plant. A descriptive cross-sectional study was carried out in Soba locality, Khartoum, Sudan. An interviewer-administrated questionnaire was assigned to 462 residents of the area living in four geographically distributed squares around the sewage plant. The data was analyzed in SPSS; Cronbach's alpha reliability scale of measurement was used to check the internal validity of six variables related to the quality of life...
December 31, 2017: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/29456777/toe-gap-force-is-related-to-ultrasonic-parameter-of-calcaneus-bone-status-in-general-population
#18
Tsuyoshi Tajika, Atsushi Yamamoto, Noboru Oya, Takanori Kitagawa, Hiroki Kobayashi, Hitoshi Shitara, Haku Iizuka, Kenji Takagishi, Hirotaka Chikuda
Background: Elucidating the relation between bone health condition and muscle strength can provide useful knowledge for Japan's super-aged society. This study ascertained the Speed Of Sound (SOS) of the calcaneus and upper and lower limb muscle strength in a general population. Methods: Medical examinations were conducted of 277 adult residents (100 men, 177 women; average age 67.1 years) of a mountain village. Bilateral hand grip and hand key pinch strength were measured...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29456595/geographical-access-to-critical-care-services-in-scotland
#19
Philip Emerson, Naomi Dodds, David R Green, Jan O Jansen
Background: Critical illness requires specialist and timely management. The aim of this study was to create a geographic accessibility profile of the Scottish population to emergency departments and intensive care units. Methods: This was a descriptive, geographical analysis of population access to 'intermediate' and 'definitive' critical care services in Scotland. Access was defined by the number of people able to reach services within 45 to 60 min, by road and by helicopter...
February 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29456552/identification-of-single-nucleotide-non-coding-driver-mutations-in-cancer
#20
REVIEW
Kok A Gan, Sebastian Carrasco Pro, Jared A Sewell, Juan I Fuxman Bass
Recent whole-genome sequencing studies have identified millions of somatic variants present in tumor samples. Most of these variants reside in non-coding regions of the genome potentially affecting transcriptional and post-transcriptional gene regulation. Although a few hallmark examples of driver mutations in non-coding regions have been reported, the functional role of the vast majority of somatic non-coding variants remains to be determined. This is because the few driver variants in each sample must be distinguished from the thousands of passenger variants and because the logic of regulatory element function has not yet been fully elucidated...
2018: Frontiers in Genetics
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