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Oscar Contreras Ortiz, Diaa Ee Rizk, Gabriele Falconi, Lucas Schreiner, Viridiana Gorbea Chávez
AIM: For four decades, the training for fellows in Urogynecology has been defined by taking into account the proposals of the relevant international societies. Primary health care providers and general OB/GYN practitioners could not find validated guidelines for the integration of knowledge in pelvic floor dysfunctions. The FIGO Working Group (FWG) in Pelvic Floor Medicine and Reconstructive Surgery has looked for the consensus of international opinion leaders in order to develop a set of minimal requirements of knowledge and skills in this area...
February 2017: Neurourology and Urodynamics
Marie Méan, Antoine Garnier, Nathalie Wenger, Julien Castioni, Gérard Waeber, Pedro Marques-Vidal
BACKGROUND: Recent implementation of electronic health records (EHR) has dramatically changed medical ward organization. While residents in general internal medicine use EHR systems half of their working time, whether computer usage impacts residents' workflow remains uncertain. We aimed to observe the frequency of task-switches occurring during resident's work and to assess whether computer usage was associated with task-switching. METHODS: In a large Swiss academic university hospital, we conducted, between May 26 and July 24, 2015 a time-motion study to assess how residents in general internal medicine organize their working day...
2017: PloS One
Emilija Marinkovic, Radmila Djokic, Ivana Lukic, Ana Filipovic, Aleksandra Inic-Kanada, Dejana Kosanovic, Marija Gavrovic-Jankulovic, Marijana Stojanovic
We demonstrated that a recombinant banana lectin (rBanLec), which structural characteristics and physiological impacts highly resemble those reported for its natural counterparts, binds murine peritoneal macrophages and specifically modulates their functional characteristics. By using rBanLec in concentrations ranging from 1 μg to 10 μg to stimulate resident (RMs) and thioglycollate-elicited (TGMs) peritoneal macrophages from BALB/c and C57BL/6 mice, we have shown that effects of rBanLec stimulation depend on its concentration but also on the functional status of macrophages and their genetic background...
2017: PloS One
Sarah M Dry, Sarah B Garrett, Barbara A Koenig, Arleen F Brown, Michael M Burgess, Jen R Hult, Holly Longstaff, Elizabeth S Wilcox, Sigrid Karina Madrigal Contreras, Arturo Martinez, Elizabeth A Boyd, Daniel Dohan
United States-based biorepositories are on the cusp of substantial change in regulatory oversight at the same time that they are increasingly including samples and data from large populations, e.g. all patients in healthcare system. It is appropriate to engage stakeholders from these populations in new governance arrangements. We sought to describe community recommendations for biorepository governance and oversight using deliberative community engagement (DCE), a qualitative research method designed to elicit lay perspectives on complex technical issues...
2017: PloS One
Masaharu Tsubokura, Michio Murakami, Shuhei Nomura, Tomohiro Morita, Yoshitaka Nishikawa, Claire Leppold, Shigeaki Kato, Masahiro Kami
After the 2011 Fukushima Daiichi nuclear power plant accident, little information has been available on individual doses from external exposure among residents living in radioactively contaminated areas near the nuclear plant; in the present study we evaluated yearly changes in the doses from external exposure after the accident and the effects of decontamination on external exposure. This study considered all children less than 16 years of age in Soma City, Fukushima who participated in annual voluntary external exposure screening programs during the five years after the accident (n = 5,363)...
2017: PloS One
Tom Lung, Kirsten Howard, Christopher Etherton-Beer, Moira Sim, Gill Lewin, Glenn Arendts
BACKGROUND: Accurately assessing changes in the quality of life of older people living permanently in nursing homes is important. The multi-attribute utility instrument most commonly used and recommended to assess health-related quality of life in the nursing home population is the three-level EuroQol EQ-5D-3L. To date, there have been no studies using the Health Utilities Index Mark III (HUI3). The purpose of this study was to compare the level of agreement and sensitivity to change of the EQ-5D-3L and HUI3 in a nursing home population...
2017: PloS One
W Grainger Hunt, J David Wiens, Peter R Law, Mark R Fuller, Teresa L Hunt, Daniel E Driscoll, Ronald E Jackman
Raptors are exposed to a wide variety of human-related mortality agents, and yet population-level effects are rarely quantified. Doing so requires modeling vital rates in the context of species life-history, behavior, and population dynamics theory. In this paper, we explore the details of such an analysis by focusing on the demography of a resident, tree-nesting population of golden eagles (Aquila chrysaetos) in the vicinity of an extensive (142 km2) windfarm in California. During 1994-2000, we tracked the fates of >250 radio-marked individuals of four life-stages and conducted five annual surveys of territory occupancy and reproduction...
2017: PloS One
Zuzanna Rowinska, Thomas A Koeppel, Maryam Sanati, Hubert Schelzig, Joachim Jankowski, Christian Weber, Alma Zernecke, Elisa A Liehn
BACKGROUND: The CX3C chemokine receptor CX3CR1 is expressed on monocytes as well as tissue resident cells, such as smooth muscle cells (SMCs). Its role in atherosclerotic tissue remodeling of the aorta after transplantation has not been investigated. METHODS: We here have orthotopically transplanted infrarenal Cx3cr1-/-Apoe-/- and Cx3cr1+/+Apoe-/- aortic segments into Apoe-/-mice, as well as Apoe-/- aortic segments into Cx3cr1-/-Apoe-/- mice. The intimal plaque size and cellular plaque composition of the transplanted aortic segment were analyzed after four weeks of atherogenic diet...
2017: PloS One
Adina F Turcu, Richard J Auchus
PURPOSE OF REVIEW: The adrenal gland is considered a source of weak androgens, such as dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. Emerging evidence proposes a set of 11-oxygenated 19-carbon (11oxC19) adrenal-derived steroids as clinically important androgens. Such steroids include 11β-hydroxyandrostenedione, 11-ketoandrostenedione, 11β-hydroxytestosterone, and 11-ketotestosterone. The present review will discuss the synthesis, androgenic activity, and clinical implications of the 11oxC19 steroids...
February 23, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
Hadijat M Makinde, Talia B Just, Carla M Cuda, Harris Perlman, Steven J Schwulst
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that presents as a late sequela from traumatic brain injury (TBI). Traumatic brain injury is a growing and under-recognized public health concern with a high degree of morbidity and large associated global costs. While the immune response to TBI is complex, its contribution to the development of CTE remains largely unknown. In this review, we summarize the current understanding of the link between CTE and the resident innate immune system of the brain- microglia...
February 23, 2017: Shock
Frank W Garrison, Valorie Dearmon, Rebecca J Graves
No abstract text is available yet for this article.
March 2017: Nursing Management
Elizabeth R Mueller, Alan J Wolfe, Linda Brubaker
PURPOSE OF REVIEW: The newly discovered female urinary microbiota has the potential to deepen our understanding of urinary tract health and disease, including common lower urinary tract conditions such as urinary incontinence and urinary tract infection. The spectrum of painful bladder disorders and other less common conditions also may benefit from additional research that includes consideration of the resident bacterial community of the female bladder. The present review provides a clinical context for the rapidly emerging research regarding the female urinary microbiota and its relationships with urinary tract conditions of interest...
February 23, 2017: Current Opinion in Urology
Amy K Williams, Rose A Cotter, Vivana Bompadre, Michael J Goldberg, Suzanne S Steinman
BACKGROUND: The purpose of the study was to investigate whether a safety checklist could be used consistently in an academic center, and, whether its presence correlates with a decreased rate of complications, and therefore, improved overall patient safety. METHODS: Data from 3 years before and after the implementation of the checklist were compared. Prechecklist data from August 2008 through August of 2011, including all operative supracondylar humerus fractures treated at our institution, were retrospectively reviewed...
February 23, 2017: Journal of Pediatric Orthopedics
Peter Glen, Fady Balaa, Franco Momoli, Louise Martin, Dorothy Found, Angel Arnaout
The CanMEDS framework is ubiquitous in Canadian postgraduate medical education; however, training programs do not have a universal method of assessing competence. We set out to develop a novel portfolio that allowed trainees to generate a longitudinal record of their training and development within the framework. The portfolio provided an objective means for the residency program director to document and evaluate resident progress within the CanMEDS roles.
December 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Ahmed Aoude, Hamzah Alhamzah, Maryse Fortin, Peter Jarzem, Jean Ouellet, Michael H Weber
BACKGROUND: The training of orthopedic residents in adequate pedicle screw placement is very important. We sought to investigate orthopedic residents' perspectives on the use of computer-assisted surgery (CAS) in a training trial. METHODS: Orthopedic residents were randomly assigned to independently place a screw using the free-hand technique and the CAS technique on 1 of 3 cadavers (Cobb angles 5º, 15º and 67º) at randomly selected thoracolumbar vertebral levels...
December 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Stephanie Mowat, Martina Reslerova, Jeffrey Sisler
INTRODUCTION: International medical graduates (IMGs) seeking licensure in Canada have been recruited to practise in medically underserviced areas, but retention of these physicians remains a concern. This study explored retention of IMG family physicians in Manitoba and its predictors. METHODS: We used data from the University of Manitoba, provincial registries and Manitoba Health. Inclusion criteria were IMGs who completed University of Manitoba IMG training or assessment programs, and their return-of-service...
2017: Canadian Journal of Rural Medicine
John Quinn Gentles
This essay was selected as the winner of the 2015 Canadian Undergraduate Surgical Education Committee student essay competition. It was written in response to the prompt: "How is your school preparing you for residency - be it surgical or medical?".
February 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Sergio Piña-Oviedo, Carlos Ortiz-Hidalgo, Alberto G Ayala
CONTEXT: - Colors are important to all living organisms because they are crucial for camouflage and protection, metabolism, sexual behavior, and communication. Human organs obviously have color, but the underlying biologic processes that dictate the specific colors of organs and tissues are not completely understood. A literature search on the determinants of color in human organs yielded scant information. OBJECTIVES: - To address 2 specific questions: (1) why do human organs have color, and (2) what gives normal and pathologic tissues their distinctive colors? DATA SOURCES: - Endogenous colors are the result of complex biochemical reactions that produce biologic pigments: red-brown cytochromes and porphyrins (blood, liver, spleen, kidneys, striated muscle), brown-black melanins (skin, appendages, brain nuclei), dark-brown lipochromes (aging organs), and colors that result from tissue structure (tendons, aponeurosis, muscles)...
March 2017: Archives of Pathology & Laboratory Medicine
Monika Ewa Dzieciuch-Rojek, Chetan Poojari, Jan Bednar, Alex Bunker, Bartłomiej Kozik, Maria Nowakowska, Ilpo Vattulainen, Pawel Wydro, Mariusz Kepczynski, Tomasz Rog
Itraconazole (ITZ) is an antifungal agent used clinically to treat mycotic infections. However, its therapeutic effects are limited by low solubility in aqueous media. Liposome-based delivery systems (LDS) have been proposed as a delivery mechanism for ITZ to solve this problem. Further, PEGylation, the inclusion in the formulation of a protective "stealth sheath" of poly(ethylene glycol) around carrier particles is widely used to increase the circulation time in the bloodstream, and hence efficacy. Together, these themes underlie the importance to strengthen our mechanistic and structural understanding of ITZ incorporation into liposomes both with and without PEGylation, since it can provide a potential foundation for the rational design of LDS-based systems for the delivery of ITZ, using alternate protective polymers or formulations...
February 24, 2017: Molecular Pharmaceutics
Yana A Lyon, Georgette M Sabbah, Ryan R Julian
The eye lens crystallins represent an ideal target for studying the effects of aging on protein structure. Herein we examine separately the water-soluble (WS) and water-insoluble (WI) crystallin fractions and identify sites of isomerization and epimerization. Both collision-induced dissociation (CID) and radical-directed dissociation (RDD) are needed for detection of these non-mass shifting post-translational modifications. Isomerization levels differ significantly between the WS and the WI fractions from sheep, pig, and cow eye lenses...
February 24, 2017: Journal of Proteome Research
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