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https://www.readbyqxmd.com/read/28109068/the-impact-of-dermoscopy-on-melanoma-detection-in-the-practice-of-dermatologists-in-europe-results-of-a-pan-european-survey
#1
A M Forsea, P Tschandl, I Zalaudek, V Del Marmol, H P Soyer, G Argenziano, A C Geller
BACKGROUND: Dermoscopy is a widely used technique that can increase the sensitivity and specificity of melanoma detection. Information is lacking on the impact of dermoscopy use on the detection of melanoma in the real-life practice of European dermatologists. OBJECTIVE: To identify factors that influence the benefit of using dermoscopy for increasing melanoma detection and lowering the number of unnecessary biopsies in the practice of European dermatologists. METHODS: We conducted a survey of dermatologists registered in 32 European countries regarding: the demographic and practice characteristics, dermoscopy training and use, opinions on dermoscopy and the self-estimated impact of dermoscopy use on the number of melanomas detected and the number of unnecessary biopsies performed in practice...
January 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28108971/capsule-commentary-on-neff-et-al-teaching-structure-a-qualitative-evaluation-of-a-structural-competency-training-for-resident-physicians
#2
Sivan Spitzer-Shohat, Mary Cj Rudolf
No abstract text is available yet for this article.
January 20, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28108882/prevalence-of-vitamin-b12-and-folate-deficiency-in-school-children-residing-at-high-altitude-regions-in-india
#3
Aakriti Gupta, Umesh Kapil, Lakshmy Ramakrishnan, Ravindra Mohan Pandey, Chander Prakash Yadav
OBJECTIVE: To assess the prevalence of vitamin B12 and folate deficiencies among children residing at high altitude regions of Himachal Pradesh, India. METHODS: A total of 215 school children in the age group of 6-18 y were included. Biochemical estimation of serum vitamin B12 and folate levels was undertaken using chemiluminescence immunoassay method. The consumption pattern of foods high in dietary vitamin B12 and folate was recorded using Food Frequency Questionnaire...
January 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28108872/neighborhood-disorder-and-physical-activity-among-older-adults-a-longitudinal-study
#4
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Neighborhood physical disorder-the visual indications of neighborhood deterioration-may inhibit outdoor physical activity, particularly among older adults. However, few previous studies of the association between neighborhood disorder and physical activity have focused on this sensitive population group, and most have been cross-sectional. We examined the relationship between neighborhood physical disorder and physical activity, measured using the Physical Activity Scale for the Elderly (PASE), in a three-wave longitudinal study of 3497 New York City residents aged 65-75 at baseline weighted to be representative of the older adult population of New York City...
January 20, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28108783/health-symptoms-in-relation-to-temperature-humidity-and-self-reported-perceptions-of-climate-in-new-york-city-residential-environments
#5
Ashlinn Quinn, Jeffrey Shaman
Little monitoring has been conducted of temperature and humidity inside homes despite the fact that these conditions may be relevant to health outcomes. Previous studies have observed associations between self-reported perceptions of the indoor environment and health. Here, we investigate associations between measured temperature and humidity, perceptions of indoor environmental conditions, and health symptoms in a sample of New York City apartments. We measured temperature and humidity in 40 New York City apartments during summer and winter seasons and collected survey data from the households' residents...
January 20, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28108639/prevalence-of-epilepsy-seizures-as-a-comorbidity-of-neurologic-disorders-in-nursing-homes
#6
Angela K Birnbaum, Ilo E Leppik, Kenneth Svensden, Lynn E Eberly
OBJECTIVE: To determine the prevalence of epilepsy/seizure (epi/sz) comorbid with other neurologic disorders in elderly nursing home residents and to examine demographic and regional variability and associations with clinical characteristics. METHODS: We studied 5 cross-sectional cohorts of all residents in any Medicare/Medicaid-certified nursing home in the United States on July 15 of each year from 2003 to 2007. Epi/sz was identified by ICD-9 codes (345.xx or 780...
January 20, 2017: Neurology
https://www.readbyqxmd.com/read/28108526/vaps-and-acbd5-tether-peroxisomes-to-the-er-for-peroxisome-maintenance-and-lipid-homeostasis
#7
Rong Hua, Derrick Cheng, Étienne Coyaud, Spencer Freeman, Erminia Di Pietro, Yuqing Wang, Adriano Vissa, Christopher M Yip, Gregory D Fairn, Nancy Braverman, John H Brumell, William S Trimble, Brian Raught, Peter K Kim
Lipid exchange between the endoplasmic reticulum (ER) and peroxisomes is necessary for the synthesis and catabolism of lipids, the trafficking of cholesterol, and peroxisome biogenesis in mammalian cells. However, how lipids are exchanged between these two organelles is not understood. In this study, we report that the ER-resident VAMP-associated proteins A and B (VAPA and VAPB) interact with the peroxisomal membrane protein acyl-CoA binding domain containing 5 (ACBD5) and that this interaction is required to tether the two organelles together, thereby facilitating the lipid exchange between them...
January 20, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28108524/acbd5-and-vapb-mediate-membrane-associations-between-peroxisomes-and-the-er
#8
Joseph L Costello, Inês G Castro, Christian Hacker, Tina A Schrader, Jeremy Metz, Dagmar Zeuschner, Afsoon S Azadi, Luis F Godinho, Victor Costina, Peter Findeisen, Andreas Manner, Markus Islinger, Michael Schrader
Peroxisomes (POs) and the endoplasmic reticulum (ER) cooperate in cellular lipid metabolism and form tight structural associations, which were first observed in ultrastructural studies decades ago. PO-ER associations have been suggested to impact on a diverse number of physiological processes, including lipid metabolism, phospholipid exchange, metabolite transport, signaling, and PO biogenesis. Despite their fundamental importance to cell metabolism, the mechanisms by which regions of the ER become tethered to POs are unknown, in particular in mammalian cells...
January 20, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28108486/regulation-of-the-immune-response-by-tgf-%C3%AE-from-conception-to-autoimmunity-and-infection
#9
Shomyseh Sanjabi, Soyoung A Oh, Ming O Li
Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive and inflammatory immune responses. After 30 years of intense study, we have only begun to elucidate how TGF-β alters immunity under various conditions. Under steady-state conditions, TGF-β regulates thymic T-cell selection and maintains homeostasis of the naïve T-cell pool. TGF-β inhibits cytotoxic T lymphocyte (CTL), Th1-, and Th2-cell differentiation while promoting peripheral (p)Treg-, Th17-, Th9-, and Tfh-cell generation, and T-cell tissue residence in response to immune challenges...
January 20, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28108326/neuromolecular-correlates-of-cooperation-and-conflict-during-territory-defense-in-a-cichlid-fish
#10
Chelsea A Weitekamp, Hans A Hofmann
Cooperative behavior is widespread among animals, yet the neural mechanisms have not been studied in detail. We examined cooperative territory defense behavior and associated neural activity in candidate forebrain regions in the cichlid fish, Astatotilapia burtoni. We find that a territorial male neighbor will engage in territory defense dependent on the perceived threat of the intruder. The resident male, on the other hand, engages in defense based on the size and behavior of his partner, the neighbor. In the neighbor, we find that an index of engagement correlates with neural activity in the putative homolog of the mammalian basolateral amygdala and in the preoptic area, as well as in preoptic dopaminergic neurons...
January 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28108310/autophagic-dysregulation-in-doxorubicin-cardiomyopathy
#11
REVIEW
Jordan J Bartlett, Purvi C Trivedi, Thomas Pulinilkunnil
Doxorubicin (DOX)-induced cardiotoxicity has been a well-known phenomenon to clinicians and scientists for decades; however, molecular mechanisms underlying DOX cardiotoxicity are still being uncovered. Although prior research has mostly implicated disruptive events in the nucleus and mitochondria to be contributing to DOX cardiomyopathy, recent discoveries in the cellular waste management process, autophagy, have highlighted the role of the lysosome, an organelle central to autophagy, in this pathology. Indeed, dysregulation of lysosomal autophagy is observed in pre-clinical models of DOX cardiotoxicity...
January 17, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28108206/circadian-variation-in-post-void-residual-in-nursing-home-residents-with-moderate-impairment-in-activities-of-daily-living
#12
Veerle Decalf, Anja Huion, Marie-Astrid Denys, Candy Kumps, Mirko Petrovic, Karel Everaert
BACKGROUND: Despite the conflicting evidence about postvoid residual (PVR) and its variation in time and corresponding voided volume (VV), studies with urinary diaries and systematic measurements of PVR after each void have never been conducted in nursing home (NH) residents. OBJECTIVE: To describe the circadian rhythm of PVR and residual fraction (RF, the net quantity of PVR) and to identify the time window with the highest PVR and RF. DESIGN, SETTING, AND PARTICIPANTS: A multicentre prospective study conducted between 2014 and 2015 in 5 Belgian NHs...
January 17, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28108204/the-dietary-approaches-to-stop-hypertension-diet-cognitive-function-and-cognitive-decline-in-american-older-women
#13
Agnes A M Berendsen, Jae H Kang, Ondine van de Rest, Edith J M Feskens, Lisette C P G M de Groot, Francine Grodstein
OBJECTIVES: To examine the association between long-term adherence to the Dietary Approaches to Stop Hypertension (DASH) diet with cognitive function and decline in older American women. DESIGN: Prospective cohort study. SETTING: The Nurses' Health Study, a cohort of registered nurses residing in 11 US states. PARTICIPANTS: A total of 16,144 women from the Nurses' Health Study, aged ≥70 years, who underwent cognitive testing a total of 4 times by telephone from 1995 to 2001 (baseline), with multiple dietary assessments between 1984 and the first cognitive examination...
January 17, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28108154/collaborative-design-of-a-health-care-experience-survey-for-persons-with-disability
#14
Lisa I Iezzoni, Holly Matulewicz, Sarah A Marsella, Kimberley S Warsett, Dennis Heaphy, Karen Donelan
BACKGROUND: When assessing results of health care delivery system reforms targeting persons with disability, quality metrics must reflect the experiences and perspectives of this population. OBJECTIVE: For persons with disability and researchers to develop collaboratively a survey that addresses critical quality questions about a new Massachusetts health care program for persons with disability dually-eligible for Medicare and Medicaid. METHODS: Persons with significant physical disability or serious mental health diagnoses participated fully in all research activities, including co-directing the study, co-moderating focus groups, performing qualitative analyses, specifying survey topics, cognitive interviewing, and refining survey language...
January 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28108130/contribution-of-sociodemographic-and-lifestyle-related-factors-to-the-differences-in-metabolic-syndrome-among-russian-somali-and-kurdish-migrants-compared-with-finns
#15
N Skogberg, T Laatikainen, A Jula, T Härkänen, E Vartiainen, P Koponen
BACKGROUND: Metabolic syndrome (MetS) is associated with a substantially increased risk for cardiovascular disease and diabetes. We examined the contribution of length of residence, socioeconomic position and lifestyle-related factors to the differences in the prevalence of MetS among migrants compared with Finns. METHODS: Cross-sectional data from randomly sampled 30-64year-old health examination participants (318 Russian, 212 Somali, and 321 Kurdish origin migrants) of the Migrant Health and Wellbeing Survey (2010-2012) were used...
January 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28108116/maternal-exposure-to-ambient-air-pollution-and-risk-of-early-childhood-cancers-a-population-based-study-in-ontario-canada
#16
Éric Lavigne, Marc-André Bélair, Minh T Do, David M Stieb, Perry Hystad, Aaron van Donkelaar, Randall V Martin, Daniel L Crouse, Eric Crighton, Hong Chen, Jeffrey R Brook, Richard T Burnett, Scott Weichenthal, Paul J Villeneuve, Teresa To, Sabit Cakmak, Markey Johnson, Abdool S Yasseen, Kenneth C Johnson, Marianna Ofner, Lin Xie, Mark Walker
BACKGROUND: There are increasing concerns regarding the role of exposure to ambient air pollution during pregnancy in the development of early childhood cancers. OBJECTIVE: This population based study examined whether prenatal and early life (<1year of age) exposures to ambient air pollutants, including nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters ≤2.5μm (PM2.5), were associated with selected common early childhood cancers in Canada...
January 17, 2017: Environment International
https://www.readbyqxmd.com/read/28108095/indoor-temperature-and-humidity-in-new-york-city-apartments-during-winter
#17
Ashlinn Quinn, Jeffrey Shaman
BACKGROUND: Concerns about indoor residential humidity have largely centered on dampness prevention. Overly dry air, however, may favor the survival of some viruses and hence respiratory infections. Many residents employ portable humidifiers to humidify their home environment, yet the effect of these humidifiers on indoor humidity is not known. METHODS: We monitored indoor temperature and humidity in 34 apartments in New York City during winter 2014-2015. We combined information from the monitors with surveyed information on building, household, and apartment-level factors and with information on household humidifier use...
January 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28108068/challenges-training-left-handed-surgeons
#18
Maia Anderson, Erica Carballo, David Hughes, Christopher Behrer, Rishindra M Reddy
BACKGROUND: Being left-handed (LH) is considered a disadvantage in surgical training. We sought to understand the perspectives of LH trainees and surgical educators on the challenges and modifications in training LH surgeons. METHODS: A survey was distributed to surgeons, surgical residents, and medical students about challenges teaching and learning surgical technique. RESULTS: 25 LH surgeons, 65 right-handed (RH) surgeons, and 39 LH trainees completed the survey...
December 31, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/28108046/rules-of-performance-in-the-nursing-home-a-grounded-theory-of-nurse-cna-communication
#19
Connie Madden, Margaret Clayton, Heather Canary, Gail Towsley, Kristin Cloyes, Dale Lund
This study offers an initial theoretical understanding of nurse-CNA communication processes from the perspectives of nurses and CNAs who are providing direct care to residents in nursing homes. A grounded theory approach provided an understanding of nurse-CNA communication process within the complexities of the nursing home setting. Four themes (maintaining information flow, following procedure, fostering collegiality, and showing respect) describe the "rules of performance" that intertwine in nuanced relationships to guide nurse-CNA communication processes...
January 17, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28107876/a-survey-exploring-factors-associated-with-2890-companion-rabbit-owners-knowledge-of-rabbit-care-and-the-neuter-status-of-their-companion-rabbit
#20
Tasha Welch, Jason B Coe, Lee Niel, Emily McCobb
Pet owners' knowledge of pet care has been shown to affect the human-animal relationship and the welfare of companion animals. With rabbits being the third most common companion animal in many regions, and evidence of owners' lack of awareness for the standards of care required to care for companion rabbits, it is important to understand the knowledge level of rabbit owners and determine how companion rabbits are being cared for. The purpose of this study was to survey rabbit owners in order to explore factors associated with their knowledge of rabbit care, and the neuter status of their companion rabbit...
February 1, 2017: Preventive Veterinary Medicine
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