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histopathology,pathology

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https://www.readbyqxmd.com/read/28444337/utility-of-a-repeat-renal-biopsy-in-lupus-nephritis-a-single-centre-experience
#1
Angela Pakozdi, Debasish Pyne, Michael Sheaff, Ravindra Rajakariar
Background.: The role of repeat renal biopsy in lupus nephritis (LN) to guide treatment or predict prognosis has been controversial. We assessed glomerular and tubulointerstitial histological characteristics of serial renal biopsies, correlations with clinical variables and the impact on subsequent management. Methods.: Out of a large single-centre cohort of 270 biopsy- proven LN patients, 66 (24%) had serial biopsies. LN classes based on glomerular pathology were defined according to the International Society of Nephrology/Renal Pathology Society 2003 classification, while tubulointerstitial pathologies were evaluated using the revised Austin's semi-quantitative scoring system...
April 22, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28443978/characterisation-of-the-vascular-pathology-in-sigmodon-hispidus-rodentia-cricetidae-following-experimental-infection-with-angiostrongylus-costaricensis-nematoda-metastrongylidae
#2
Danielle Ingrid Bezerra de Vasconcelos, Ester Maria Mota, Marcelo Pelajo-Machado
BACKGROUND: Angiostrongylus costaricensis is a nematode that causes human abdominal angiostrongyliasis, a disease found mainly in Latin American countries and particularly in Brazil and Costa Rica. Its life cycle involves exploitation of both invertebrate and vertebrate hosts. Its natural reservoir is a vertebrate host, the cotton rat Sigmodon hispidus. The adult worms live in the ileo-colic branches of the upper mesenteric artery of S. hispidus, causing periarteritis. However, there is a lack of data on the development of vasculitis in the course of infection...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28443580/amyopathic-dermatomyositis-associated-with-histopathological-findings-of-organizing-pneumonia-and-pulmonary-vasculitis
#3
Jeong Uk Lim, Hye Seon Kang, Yong Hyun Kim, Tae Jung Kim
BACKGROUND: Clinically amyopathic dermatomyositis (CADM) is a distinct subgroup of dermatomyositis characterized by unique dermatologic manifestations without muscle involvement. CADM is frequently associated with interstitial lung disease (ILD), which usually has a rapidly progressive, fatal clinical course. Although CADM-related ILD (CADM-ILD) is well-described, data on the histopathology of CADM-ILD are limited. Organizing pneumonia and pulmonary vasculitis have rarely been reported...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28442112/experimental-infection-with-yersinia-pseudotuberculosis-in-european-brown-hare-lepus-europaeus-pallas
#4
Filippo Fratini, Ranieri Verin, Valentina V Ebani, Cecilia Ambrogi, Fabrizio Bertelloni, Barbara Turchi, Alessandro Poli, Domenico Cerri
OBJECTIVE: To investigate clinicopathological, bacteriological and pathological aspects of an experimental infection with Yersinia pseudotuberculosis (Y. pseudotuberculosis) in hares to verify the efficacy of serology for the in vivo diagnosis. Moreover, the pathogenicity of two Y. pseudotuberculosis strains was investigated in order to detect potential differences. METHODS: Twelve European brown hares (Lepus europaeus, Pallas) were experimentally infected per os and via conjunctival mucosae with Y...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28441703/in-vitro-and-in-vivo-inhibitory-effects-of-%C3%AE-mangostin-on-cholangiocarcinoma-cells-and-allografts
#5
Ratchadawan Aukkanimart, Thidarut Boonmars, Pranee Sriraj, Panupan Sripan, Jiraporn Songsri, Panaratana Ratanasuwan, Porntip Laummaunwai, Parichart Boueroy, Sukhonthip Khueangchaingkhwang, Benjamabhorn Pumhirunroj, Atchara Artchayasawat, Sirintip Boonjaraspinyo, Zhiliang Wu, Chariya Hahnvajanawong, Kulthida Vaeteewoottacharn, Sopit Wongkham
We investigated the anti-cholangiocarcinoma effect of α-mangostin from Garcinia mangostana pericarp extract (GM) in a human cholangiocarcinoma (CCA) cell line and a hamster CCA allograft model. In vitro, human CCA cells were treated with GM at various concentrations and for different time periods; then cell-cycle arrest and apoptosis were evaluated using flow cytometry, and metastatic potential with wound healing assays. In vivo, hamster allografts were treated with GM, gemcitabine (positive control) and a placebo (negative control) for 1 month; tumor weight and volume were then determined...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441637/subtle-pathological-changes-in-neocortical-temporal-lobe-epilepsy
#6
Juan G Ochoa, Diana Hentgarden, Audrey Paulzak, Melissa Ogden, Richard Pryson, Markus Lamle, Walter G Rusyniak
This was a prospective observational study to correlate the clinical symptoms, electrophysiology, imaging, and surgical pathology of patients with temporal lobe epilepsy (TLE) without hippocampal sclerosis. We selected consecutive patients with TLE and normal MRI undergoing temporal lobe resection between April and September 2015. Clinical features, imaging, and functional data were reviewed. Intracranial monitoring and language mapping were performed when it was required according to our team recommendation...
April 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28440972/a-comparison-between-the-diagnostic-accuracy-of-frozen-section-and-permanent-section-analyses-in-central-nervous-system
#7
Razie Amraei, Afshin Moradi, Hanieh Zham, Mahsa Ahadi, Maryam Baikpour, Azadeh Rakhshan
Objective: Using diagnostic pathological methods during surgery is a valuable means of determining the appropriate management for patients. Application of Frozen Section in CNS surgeries might face challenges due to friability of brain tissue and its relative inaccessibility. Various studies have evaluated the diagnostic acuity of frozen section compared to gold standard but results have been quite inconsistent. We conducted the present study to evaluate the accuracy of cryostat in diagnosing central nervous system tumors compared to the Gold Standard method...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28439599/agreement-of-histopathological-findings-of-uterine-curettage-and-hysterectomy-specimens-in-women-with-abnormal-uterine-bleeding
#8
Sanam Moradan, Raheb Ghorbani, Azita Lotfi
To examined the diagnostic value of  dilatation and curettage (D and C) in patients with abnormal uterine bleeding (AUB) by conducting a histopathological examination of endometrial tissues by D and C and hysterectomy. Methods: In this retrospective study, the medical records of 163 women who had been hospitalized  in the Obstetrics and Gynecology Ward, Amir-al-Momenin Hospital, Semnan, Iran between 2010 and 2015 for diagnostic curettage due to  AUB and who had undergone hysterectomy were investigated. The patients' characteristics and histopathologic results of curettage and hysterectomy were extracted, and sensitivity and specificity and positive and negative predictive values of curettage were calculated...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28439430/mistakes-in-ultrasound-diagnosis-of-superficial-lymph-nodes
#9
REVIEW
Ewa J Białek, Wiesław Jakubowski
The article discusses basic mistakes that can occur during ultrasound imaging of superficial lymph nodes. Ultrasound is the first imaging method used in the diseases of superficial organs and tissues, including lymph nodes. The causes of mistakes can be either dependent or independent of the performing physician. The first group of mistakes includes inappropriate interpretation of images of anatomical structures, while the latter group includes, among other things, similar ultrasound images of different pathologies...
March 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28439322/susceptibility-imaging-in-glial-tumor-grading-using-3-tesla-magnetic-resonance-mr-system-and-32-channel-head-coil
#10
Omer Aydin, Ramazan Buyukkaya, Bahattin Hakyemez
BACKGROUND: Susceptibility weighted imaging (SWI) is a velocity compensated, high-resolution three-dimensional (3D) spoiled gradient-echo sequence that uses magnitude and filtered-phase data. SWI seems to be a valuable tool for non-invasive evaluation of central nervous system gliomas. Relative cerebral blood volume (rCBV) ratio is one of the best noninvasive methods for glioma grading. Degree of intratumoral susceptibility signal (ITSS) on SWI correlates with rCBV ratio and histopathological grade...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28436167/placental-histopathology-associated-with-preeclampsia-a-systematic-review-and-meta-analysis
#11
REVIEW
Maria Letizia Falco, Janani Sivanathan, Arianna Laoreti, Basky Thilaganathan, Asma Khalil
OBJECTIVES: Preeclampsia is associated with impaired trophoblast invasion and typical villous and vascular placental lesions. The primary aim was to conduct a systematic review in order to quantify the prevalence of placental histopathological lesions in pregnancies complicated by preeclampsia. METHODS: MEDLINE, EMBASE and CINAHL were searched electronically and relevant articles reporting placental histopathological lesions were assessed according to the following criteria: study design, number of pregnancies, type of preeclampsia and whether the pathologist was blinded to the clinical information...
April 23, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28435787/high-grade-mucinous-urothelial-carcinoma-of-the-renal-collecting-system-a-case-report
#12
Priyanka Kancherla, John F Sullivan, Jyoti D Chouhan, Zachary Feuer, Daniel Diaz, Qiang Xie, Patrick Hammill, Brian K McNeil
High grade mucinous urothelial carcinoma is a rare pathological variant. There is still controversy as to its nomenclature and classification. We report the case of a 64 year old female with history of pelvic pain who was incidentally discovered to have a left upper pole renal mass. Left nephroureterectomy was performed and histopathological examination revealed high grade mucinous urothelial carcinoma. Accurate diagnosis of this distinct pathological entity will allow for better understanding of phenotypic behavior and inform best treatment strategies...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28435194/molecular-characterization-of-velogenic-viscerotropic-ranikhet-newcastle-disease-virus-from-different-outbreaks-in-desi-chickens
#13
V S Dhaygude, G K Sawale, M M Chawak, N R Bulbule, S D Moregaonkar, D S Gavhane
AIM: Diagnosis of velogenic viscerotropic Ranikhet disease from six different flocks of desi chicken in and around Mumbai by gross and histopathological examination, isolation of virus and molecular methods. MATERIALS AND METHODS: A total of 25 carcasses (varying between 2 and 6 carcasses from each flock) of six different flocks of adult desi chicken were subjected to necropsy examination for diagnosis of the disease during the span of a year (2014-2015). After thorough gross examination, the tissue samples were collected and processed for virus isolation and histopathological examination...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28434958/microsurgical-resection-following-failed-gamma-knife-radiosurgery-of-papillary-tumor-of-the-pineal-gland
#14
Anil Nanda, Piyush Kalakoti, Devi Prasad Patra, Tanmoy Maiti, Hai Sun
Primary papillary tumors of the pineal region (PTPR) are rare entities with distinct histopathological characteristics. Most common surgical approaches include the supra-cerebellar infratentorial corridor or the occipital interhemispheric approach. Gamma knife radiosurgery (GKRS) is an acceptable treatment modality for parenchymal tumors of the pineal gland, and often used as a primary treatment modality for asymptomatic and indolent lesions, and as an adjunct to surgical resection. In this presentation, we describe the surgical nuances of posterior interhemispheric approach in an elderly male with a previously failed empirical GKRS...
April 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28434924/tumor-thickness-and-histological-features-as-predictors-of-invasive-foci-within-preoperatively-diagnosed-ductal-carcinoma-in-situ
#15
Kiyoshi Mori, Masashi Takeda, Yoshinori Kodama, Hiroki Kiyokawa, Hiroyuki Yasojima, Makiko Mizutani, Yoko Ohtani, Nozomi Morikawa, Norikazu Masuda, Masayuki Mano
Small invasion into ductal carcinoma in situ (DCIS) can easily be overlooked in resected breast specimens. To disclose useful markers predictive of invasive foci within preoperatively diagnosed DCIS lesions, a retrospective histopathological comparison was made between postoperatively diagnosed invasive ductal carcinoma with a predominant intraductal component (IDCPIC) (n=43) and pure DCIS (n=82). Through a multivariate logistic regression analysis model, 5 variables (DCIS grade, "tumor thickness", extent of retraction cleft, presence of lymph node metastasis, and HER2 score) were found to be significantly associated with the presence of invasive foci within DCIS; with a cutoff point of 0...
April 20, 2017: Human Pathology
https://www.readbyqxmd.com/read/28434828/correlation-between-single-photon-emission-computed-tomography-and-histopathologic-findings-in-condylar-hyperplasia-of-the-temporomandibular-joint
#16
Rafael Martin-Granizo, José Ma Garcia-Rielo, Oscar De la Sen, Lourdes Maniegas, Alberto Berguer, Manuel De Pedro
PURPOSE: To analyse the correlation between the level of activity measured in the single photon emission computed tomography (SPECT) and the pathological findings in patients with condylar hyperplasia (CH). MATERIALS AND METHODS: All patients evaluated in our department between 2007 and 2014 with a diagnosis of condylar hyperplasia who had undergone SPECT, evidenced signs of activity, and had undergone surgery were included. We included 28 patients, of whom 20 were women and 8 men...
March 24, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28434817/the-protective-effect-of-hyperoside-on-carbon-tetrachloride-induced-chronic-liver-fibrosis-in-mice-via-upregulation-of-nrf2
#17
Liyi Zou, Shaoru Chen, Li Li, Tie Wu
CONTEXT: Hyperoside was used to treat cardiovascular disease for many years in China. It was shown great effect on regulation of lipid metabolism. But there is lack of reports about the effects of hyperoside on liver diseases. OBJECTIVE: This study was designed to investigate the potentially protective effects of hyperoside and the role of transcription factor nuclear factor-erythroid 2(NF-E2)-related factor 2 (Nrf2) signaling in the regulation on Carbon Tetrachloride (CCl4)-induced chronic liver fibrosis in mice...
April 20, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28433850/surgical-resection-and-histopathological-analysis-of-a-thrombosed-giant-fusiform-mca-aneurysm-after-initial-treatment-with-a-flow-diversion-construct
#18
Jayson Sack, Vincent Cheung, Deirdre Amaro, Arvin R Wali, David R Santiago-Dieppa, J Scott Pannell, Alexander A Khalessi
BACKGROUND: We describe the histopathology of an un-ruptured, giant calcified left MCA fusiform aneurysm initially treated with endovascular flow diversion. The flow diversion construct underwent post-operative in-stent thrombosis, necessitating surgical resection of the aneurysm to eliminate mass effect. METHODS: A 75-year-old woman with a known left MCA aneurysm presented to the Emergency Department with moderate right hemibody weakness. Due to the clinical and radiographic progression of the aneurysm, the patient was offered treatment...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28433587/pharmacokinetic-and-toxicology-comparator-testing-of-biosimilar-drugs-assessing-need
#19
Paul Baldrick
A key element in the development of a biosimilar molecule is the comparability of the biological activity/nonclinical similarity to the innovator drug. Although some regulatory guidelines are encouraging little or no in vivo testing, currently a common practice is to perform at least one toxicology and/or one pharmacokinetic (PK) study to assess if any different findings occur for in-life, clinical pathology and histopathological parameters or in exposure. An exercise was performed in which the results of such testing were evaluated...
April 20, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28432872/human-effector-memory-t-helper-cells-engage-with-mouse-macrophages-and-cause-graft-versus-host-like-pathology-in-skin-of-humanized-mice-used-in-a-nonclinical-immunization-study
#20
Bala S Sundarasetty, Valery Volk, Sebastian J Theobald, Susanne Rittinghausen, Dirk Schaudien, Vanessa Neuhaus, Constanca Figueiredo, Andreas Schneider, Laura Gerasch, Adele Mucci, Thomas Moritz, Constantin von Kaisenberg, Loukia M Spineli, Katherina Sewald, Armin Braun, Henning Weigt, Arnold Ganser, Renata Stripecke
Humanized mice engrafted with human hematopoietic stem cells and developing functional human T-cell adaptive responses are in critical demand to test human-specific therapeutics. We previously showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65 viral antigen (iDCpp65) exhibited a faster development and maturation of T cells. Herein, we evaluated these effects in a long-term (36 weeks) nonclinical model using two stem cell donors to assess efficacy and safety. Relative to baseline, iDCpp65 immunization boosted the output of effector memory CD4(+) T cells in peripheral blood and lymph nodes...
April 19, 2017: American Journal of Pathology
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