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https://www.readbyqxmd.com/read/29241952/downregulation-of-common-cytokine-receptor-%C3%AE-chain-inhibits-inflammatory-responses-in-macrophages-stimulated-with-riemerella-anatipestifer
#1
Fahmida Afrin, Cherry P Fernandez, Rochelle A Flores, Woo H Kim, Jipseol Jeong, Hong H Chang, Suk Kim, Hyun S Lillehoj, Wongi Min
Th17-cell-mediated inflammation is affected by the soluble form of common cytokine receptor γ chain (γc). We previously suggested that inflammatory cytokines including interleukin (IL)-17A are associated with Riemerella anatipestifer infection, which a harmful bacterial pathogen in ducks. Here, the expression profiles of membrane-associated γc (duγc-a) and soluble γc (duγc-b) in R. anatipestifer-stimulated splenic lymphocytes and macrophages, and in the spleens and livers of R. anatipestifer-infected ducks, were investigated...
December 11, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29241410/co-relation-of-overall-survival-with-peripheral-blood-based-inflammatory-biomarkers-in-advanced-stage-non-small-cell-lung-cancer-treated-with-anti-programmed-cell-death-1-therapy-results-from-a-single-institutional-database
#2
Abdul Rafeh Naqash, Chipman Robert Geoffrey Stroud, Muhammad Umer Butt, Grace K Dy, Aparna Hegde, Mahvish Muzaffar, Li V Yang, Maida Hafiz, Cynthia R Cherry, Paul R Walker
No abstract text is available yet for this article.
December 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29240986/the-essential-elements-of-a-risk-governance-framework-for-current-and-future-nanotechnologies
#3
Vicki Stone, Martin Führ, Peter H Feindt, Hans Bouwmeester, Igor Linkov, Stefania Sabella, Finbarr Murphy, Kilian Bizer, Lang Tran, Marlene Ågerstrand, Carlos Fito, Torben Andersen, Diana Anderson, Enrico Bergamaschi, John W Cherrie, Sue Cowan, Jean-Francois Dalemcourt, Michael Faure, Silke Gabbert, Agnieszka Gajewicz, Teresa F Fernandes, Danail Hristozov, Helinor J Johnston, Terry C Lansdown, Stefan Linder, Hans J P Marvin, Martin Mullins, Kai Purnhagen, Tomasz Puzyn, Araceli Sanchez Jimenez, Janeck J Scott-Fordsmand, George Streftaris, Martie van Tongeren, Nicolas H Voelcker, George Voyiatzis, Spyros N Yannopoulos, P Marijn Poortvliet
Societies worldwide are investing considerable resources into the safe development and use of nanomaterials. Although each of these protective efforts is crucial for governing the risks of nanomaterials, they are insufficient in isolation. What is missing is a more integrative governance approach that goes beyond legislation. Development of this approach must be evidence based and involve key stakeholders to ensure acceptance by end users. The challenge is to develop a framework that coordinates the variety of actors involved in nanotechnology and civil society to facilitate consideration of the complex issues that occur in this rapidly evolving research and development area...
December 14, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29239897/ex-vivo-expression-of-chemokine-receptors-on-cells-surrounding-cutaneous-nerves-in-patients-with-hiv-associated-sensory-neuropathy
#4
Jenjira Mountford, Fitri Octaviana, Riwanti Estiasari, Denise Dewanto Setiawan, Ibnu Ariyanto, Silvia Lee, Jessica Gaff, Constance Chew, Connie Jackaman, Peter Kamerman, Catherine Cherry, Patricia Price
OBJECTIVE: HIV-associated sensory neuropathy (HIV-SN) remains common in HIV+ individuals receiving anti-retroviral therapy (ART), even though neurotoxic anti-retroviral drugs (e.g. stavudine) have been phased out of use. Accumulating evidence indicates that the neuropathy is immune-mediated. We hypothesise that chemokines produced locally in the skin promote migration of macrophages and T-cells into the tissue, damaging cutaneous nerves causing HIV-SN. DESIGN: We assessed chemokine receptor expression on infiltrating CD14 and CD3 cells around cutaneous nerves in standardised skin biopsies from HIV-SN+ patients (n = 5), HIV-SN- patients (n = 9) and healthy controls (n = 4)...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239552/the-use-of-geographic-information-system-as-a-tool-for-schistosomiasis-surveillance-in-the-province-of-davao-del-norte-the-philippines
#5
Vicente Y Belizario, John Paul Caesar R Delos Trinos, Berne Silawan, Chiqui M De Veyra, Agapito Hornido, Hansel Amoguis, Dominic Basalo, Cherry Dema-Ala, Irenn Mantilla, Rosele Layan
Schistosomiasis (SCH) in The Philippines is caused by Schistosoma japonicum and remains endemic in 28 provinces in 12 regions. Effective SCH control requires describing areas at risk where control efforts may be focused. This study aims at demonstrating the utility of geographical information system (GIS) as a tool for SCH surveillance in the province of Davao del Norte. Qualitative and quantitative data on SCH determinants, obtained from local government offices, partner agencies and institutions, were standardised, formatted and incorporated into a GIS map...
November 6, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29236992/the-effects-of-aging-on-the-regulation-of-t-tubular-ica-by-caveolin-in-mouse-ventricular-myocytes
#6
Cherrie H T Kong, Simon M Bryant, Judy J Watson, Hanne C Gadeberg, David M Roth, Hemal H Patel, Mark B Cannell, Clive H Orchard, Andrew F James
Aging is associated with diminished cardiac function in males. Cardiac excitation-contraction coupling in ventricular myocytes involves Ca influx via the Ca current (ICa) and Ca release from the sarcoplasmic reticulum, which occur predominantly at t-tubules. Caveolin-3 regulates t-tubular ICa, partly through PKA, and both ICa and caveolin-3 decrease with age. We therefore investigated ICa and t-tubule structure and function in cardiomyocytes from male WT and caveolin-3-overexpressing (Cav-3OE) mice at 3 and 24 months of age...
December 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29227543/edible-coating-using-a-chitosan-based-colloid-incorporating-grapefruit-seed-extract-for-cherry-tomato-safety-and-preservation
#7
Jin Sung Won, Seung Jo Lee, Hyeon Hwa Park, Kyung Bin Song, Sea C Min
Grapefruit seed extract (GSE)-containing chitosan-based coating was developed and applied to cherry tomatoes to protect them from Salmonella invasion and improve their storability. The coating colloids were produced by mixing a chitosan colloid (1% [w/w] chitosan) with GSE at various concentrations (0.5%, 0.7%, 1.0%, and 1.2% [w/w]) using high-shear mixing (10000 rpm, 2 min). Coatings with chitosan colloids containing GSE at 0.0%, 0.5%, 0.7%, and 1.0% (w/w) inactivated Salmonella on cherry tomatoes by 1.0 ± 0...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29225164/efficacy-of-high-dose-therapy-and-autologous-hematopoietic-cell-transplantation-in-gray-zone-lymphoma-a-us-multicenter-collaborative-study
#8
Mohamed A Kharfan-Dabaja, Renju Raj, Liana Nikolaenko, Sairah Ahmed, Nishitha Reddy, Sunita Nathan, Mohamad Cherry, Najla El-Jurdi, Cynthia Obiozor, Timothy S Fenske, Joo Song, Tariq Muzzafar, Ernesto Ayala, Bipin Savani, Mohamad Khawandanah, Paolo F Caimi, Mehdi Hamadani, Stephen J Forman, Mohamad Hussaini, Marcos de Lima, Horatiu Olteanu, Bijal Shah, Julio C Chavez, Monzr Al Malki, Ambuj Kumar, Siddhartha Ganguly
High-dose therapy (HDT) and autologous hematopoietic cell transplantation (auto-HCT) has been anecdotally prescribed in gray zone lymphoma (GZL), showing encouraging efficacy. We conducted a multicenter retrospective study aimed to assess outcomes after auto-HCT in 32 patients with GZL treated at 9 transplant centers in the United States. Median age of patients at transplantation was 38 (18-70) years and the majority were male (n=21, 66%). Median number of lines of therapy prior to transplantation was 2 (1-4)...
December 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29224988/linking-hiv-negative-youth-to-prevention-services-in-12-u-s-cities-barriers-and-facilitators-to-implementing-the-hiv-prevention-continuum
#9
Mimi Doll, J Dennis Fortenberry, Denise Roseland, Kathleen McAuliff, Craig M Wilson, Cherrie B Boyer
PURPOSE: Linkage of HIV-negative youth to prevention services is increasingly important with the development of effective pre-exposure prophylaxis that complements behavioral and other prevention-focused interventions. However, effective infrastructure for delivery of prevention services does not exist, leaving many programs to address HIV prevention without data to guide program development/implementation. The objective of this study was to provide a qualitative description of barriers and facilitators of linkage to prevention services among high-risk, HIV-negative youth...
December 7, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29224039/state-of-the-art-lasers-and-light-treatments-for-vascular-lesions-from-red-faces-to-vascular-malformations
#10
Manuel Valdebran, Brent Martin, Kristen M Kelly
Notable milestones in the treatment of vascular lesions have been achieved over the past century. Many cutaneous vascular lesions can be successfully treated with lightbased devices. In this review, we will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy. In addition, for several of these diagnoses, we will review medical therapies that can be combined with light-based devices to provide enhanced results...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29220616/interventions-to-improve-or-maintain-lower-limb-function-among-ambulatory-adolescents-with-cerebral-palsy-a-cross-sectional-survey-of-current-practice-in-the-uk
#11
Gerasimos Taflampas, Cherry Kilbride, Wendy Levin, Grace Lavelle, Jennifer M Ryan
OBJECTIVES: To describe physiotherapy management to improve or maintain lower-limb function among adolescents with cerebral palsy, classified in Gross Motor Function Classification System levels I-III, in the United Kingdom (UK). METHODS: A list of interventions was identified using a nominal group technique and developed into a survey, which was distributed to approximately 2,100 pediatric physiotherapists in the UK through the Association of Pediatric Chartered Physiotherapists and a private physiotherapy clinic in London between April and June 2015...
December 8, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/29219544/energy-spectrum-of-cosmic-ray-electron-and-positron-from-10%C3%A2-gev-to-3%C3%A2-tev-observed-with-the-calorimetric-electron-telescope-on-the-international-space-station
#12
O Adriani, Y Akaike, K Asano, Y Asaoka, M G Bagliesi, G Bigongiari, W R Binns, S Bonechi, M Bongi, P Brogi, J H Buckley, N Cannady, G Castellini, C Checchia, M L Cherry, G Collazuol, V Di Felice, K Ebisawa, H Fuke, T G Guzik, T Hams, M Hareyama, N Hasebe, K Hibino, M Ichimura, K Ioka, W Ishizaki, M H Israel, A Javaid, K Kasahara, J Kataoka, R Kataoka, Y Katayose, C Kato, N Kawanaka, Y Kawakubo, H S Krawczynski, J F Krizmanic, S Kuramata, T Lomtadze, P Maestro, P S Marrocchesi, A M Messineo, J W Mitchell, S Miyake, K Mizutani, A A Moiseev, K Mori, M Mori, N Mori, H M Motz, K Munakata, H Murakami, S Nakahira, J Nishimura, G A de Nolfo, S Okuno, J F Ormes, S Ozawa, L Pacini, F Palma, P Papini, A V Penacchioni, B F Rauch, S B Ricciarini, K Sakai, T Sakamoto, M Sasaki, Y Shimizu, A Shiomi, R Sparvoli, P Spillantini, F Stolzi, I Takahashi, M Takayanagi, M Takita, T Tamura, N Tateyama, T Terasawa, H Tomida, S Torii, Y Tsunesada, Y Uchihori, S Ueno, E Vannuccini, J P Wefel, K Yamaoka, S Yanagita, A Yoshida, K Yoshida, T Yuda
First results of a cosmic-ray electron and positron spectrum from 10 GeV to 3 TeV is presented based upon observations with the CALET instrument on the International Space Station starting in October, 2015. Nearly a half million electron and positron events are included in the analysis. CALET is an all-calorimetric instrument with total vertical thickness of 30 X_{0} and a fine imaging capability designed to achieve a large proton rejection and excellent energy resolution well into the TeV energy region. The observed energy spectrum over 30 GeV can be fit with a single power law with a spectral index of -3...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29215487/mortality-among-hardmetal-production-workers-pooled-analysis-of-cohort-data-from-an-international-investigation
#13
Gary M Marsh, Jeanine M Buchanich, Sarah Zimmerman, Yimeng Liu, Lauren C Balmert, Jessica Graves, Kathleen J Kennedy, Nurtan A Esmen, Hanns Moshammer, Peter Morfeld, Thomas Erren, Juliane Valérie Groß, Mei Yong, Magnus Svartengren, Hakan Westberg, Damien McElvenny, John W Cherrie
OBJECTIVES: Based on a pooled analysis of data from an international study, evaluate total and cause-specific mortality among hardmetal production workers with emphasis on lung cancer. METHODS: Study members were 32,354 workers from three companies and 17 manufacturing sites in five countries. We computed standardized mortality ratios and evaluated exposure-response via relative risk regression analysis. RESULTS: Among long-term workers, we observed overall deficits or slight excesses in deaths for total mortality, all cancers, and lung cancer and found no evidence of any exposure-response relationships for lung cancer...
December 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29214546/biology-of-a-neotropical-harlequin-stink-bug-runibia-perspicua-f
#14
A L Marsaro, A R Panizzi, T Lucini
Laboratory and field studies were conducted with nymphs and adults of the Neotropical stink bug Runibia perspicua (F.) to evaluate their biology on plants. Total nymph mortality was ca. 13% on immature fruits of Brunfelsia australis Benth. (IFBA) and 90% on raw shelled peanuts, Arachis hypogaea L. (RSP); no nymphs survived on immature pods of green bean, Phaseolus vulgaris L., or on immature fruits of privet, Ligustrum lucidum Ait. Nymph developmental time was ca. 36 on IFBA and 55 days on RSP. Body weight was significantly greater when nymphs were raised isolated compared to those raised in groups...
December 7, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/29212664/genetic-bypass-of-essential-rna-repair-enzymes-in-budding-yeast
#15
Patrick D Cherry, Laura K White, Kerri York, Jay R Hesselberth
RNA repair enzymes catalyze rejoining of an RNA molecule after cleavage of phosphodiester linkages. RNA repair in budding yeast is catalyzed by two separate enzymes that process tRNA exons during their splicing and HAC1 mRNA exons during activation of the unfolded protein response. The RNA ligase Trl1 joins 2',3'-cyclic phosphate and 5'-hydroxyl RNA fragments, creating a new phosphodiester linkage with a 2'-phosphate at the junction. The 2'-phosphate is subsequently removed by the 2'-phosphotransferase Tpt1, which catalyzes phosphate transfer to NAD+, producing nicotinamide and a unique ADP ribose metabolite...
December 6, 2017: RNA
https://www.readbyqxmd.com/read/29211837/effect-of-ovarian-hormones-and-mating-experience-on-the-preference-of-female-mice-to-investigate-male-urinary-pheromones
#16
Elizabeth A McCarthy, Ajay S Naik, Allison F Coyne, James A Cherry, Michael J Baum
In female mice the expression of receptive lordosis behavior requires estradiol and progesterone actions in the nervous system; however, the contribution of these hormones to females' motivation to seek out male pheromones is less clear. In an initial experiment, sexually naïve ovary-intact female mice preferred to investigate (make nasal contact with) testes-intact male as opposed to estrous female urine, provided they were in vaginal estrus. In a second experiment, groups of sexually naïve and mating-experienced, ovariectomized females were tested for urinary pheromone preference first without and then with ovarian hormone replacement...
December 2, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29210634/preventive-and-therapeutic-potentials-of-anthocyanins-in-diabetes-and-associated-complications
#17
Swathi Putta, Nagendra Sastry Yarla, Eswar K Kumar, Dhananjaya Bhadrapura Lakkappa, Mohammad A Kamal, Luciana Scotti, Marcus T Scotti, Ghulam Md Ashraf, George E Barreto, B Sasi Bhusana Rao, D Sarala Kumari, Gorla V Reddy, Vadim V Tarasov, Sarat Babu Imandi, Gjumrakch Aliev
Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, it is to be considering the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29209613/evaluation-of-phenolic-phytochemical-enriched-commercial-plant-extracts-on-the-in-vitro-inhibition-of-%C3%AE-glucosidase
#18
Allie Brown, Danielle Anderson, Kenneth Racicot, Sarah J Pilkenton, Emmanouil Apostolidis
Green tea (GT), cranberry (CR), and tart cherry extracts were evaluated for their ability to inhibit yeast α-glucosidase, relevant to glucose uptake. The total phenolic content (TPC), antioxidant activity, and in vitro inhibitory activity of yeast α-glucosidase were examined for the extracts in the present study. GT had higher TPC and antioxidant activity, but CR demonstrated a greater α-glucosidase inhibitory activity, on phenolic basis. CR was fractionated using LH-20 column chromatography into two fractions: 30% methanol (CME) and 70% acetone (CAE)...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29207939/tocilizumab-for-the-management-of-immune-mediated-adverse-events-secondary-to-pd-1-blockade
#19
Chipman Rg Stroud, Aparna Hegde, Cynthia Cherry, Abdul R Naqash, Nitika Sharma, Srikala Addepalli, Sulochana Cherukuri, Teresa Parent, Jessica Hardin, Paul Walker
Background Immune checkpoint inhibitors are poised to revolutionize the management of a growing number of malignancies. Unfortunately, the management of steroid-refractory immune mediated adverse events is based on a paucity of randomized data and limited to single center experiences. Our initial experience with the IL-6 receptor antagonist tocilizumab showed clinical improvement in a wide variety of irAEs. As a result, we adopted the use of tocilizumab for the management of steroid refractory irAEs. Methods The character and clinical course of irAEs were abstracted from the medical record and analyzed...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29205395/contribution-of-skin-and-stone-to-texture-measurements-of-spherical-model-fruits
#20
Andrew Rosenthal, Alice Lacresse, Emmy Voyer
Fruits are composite materials often surrounded by a skin and sometimes containing rigid stones (pits). To understand the contribution of skin and stone to the overall texture of the fruit, model fruits were constructed from moulded gelatin spheres, with rigid inclusions and a skin layer. Cross polarised light revealed the stress distribution during puncture testing and the mechanical measures of firmness, Poisson's ratio and breaking force were determined. Skin significantly raised the breaking force. Spherical stones raised the firmness - effectively reducing the deformable material in the sphere, resulting in inflated strains...
December 4, 2017: Journal of Texture Studies
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