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https://www.readbyqxmd.com/read/28727183/a-randomised-controlled-trial-on-a-nurse-led-smartphone-based-self-management-programme-for-patients-with-poorly-controlled-type-2-diabetes-a-study-protocol
#1
Wenru Wang, Betsy Seah, Ying Jiang, Violeta Lopez, Cherry Tan, Suan Tee Lim, Hongliang Ren, Yin Hao Khoo
AIM: To develop and compare a nurse-led smartphone-based self-management programme with an existing nurse-led diabetes service on health-related outcomes for patients with poorly controlled type 2 diabetes in Singapore. BACKGROUND: Over the past decades, Asia has emerged as the 'diabetes epicentre' in the world due to rapid economic development, urbanisation and nutrition transition. There is an urgent need to develop more effective care management strategies in response to this rising diabetes epidemic...
July 20, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28726804/diagnostic-cytogenetic-testing-following-positive-noninvasive-prenatal-screening-results-a-clinical-laboratory-practice-resource-of-the-american-college-of-medical-genetics-and-genomics-acmg
#2
Athena M Cherry, Yassmine M Akkari, Kimberly M Barr, Hutton M Kearney, Nancy C Rose, Sarah T South, James H Tepperberg, Jeanne M Meck
Disclaimer: ACMG Clinical Laboratory Practice Resources are developed primarily as an educational tool for clinical laboratory geneticists to help them provide quality clinical laboratory genetic services. Adherence to these practice resources is voluntary and does not necessarily assure a successful medical outcome. This Clinical Laboratory Practice Resource should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28723840/cervical-spine-evaluation-and-clearance-in-the-intoxicated-patient-a-prospective-western-trauma-association-multi-institutional-trial-and-survey
#3
Matthew J Martin, Lisa D Bush, Kenji Inaba, Saskya Byerly, Martin Schreiber, Kimberly A Peck, Galinos Barmparas, Jay Menaker, Joshua P Hazelton, Raul Coimbra, Martin D Zielinski, Carlos V R Brown, Chad G Ball, Jill R Cherry-Bukowiec, Clay Cothren Burlew, Julie Dunn, C Todd Minshall, Matthew M Carrick, Gina M Berg, Demetrios Demetriades, William Long
INTRODUCTION: Intoxication often prevents clinical clearance of the cervical spine (Csp) after trauma leading to prolonged immobilization even with a normal CT scan. We evaluated the accuracy of CT at detecting clinically significant Csp injury, and surveyed participants on related opinions and practice. METHODS: A prospective multicenter study (2013-2015) at 17 centers. All adult blunt trauma patients underwent structured clinical examination and imaging including a Csp CT, with follow-up thru discharge...
July 19, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28718000/phenological-model-of-bird-cherry-padus-racemosa-with-data-assimilation
#4
Andis Kalvāns, Tija Sīle, Gunta Kalvāne
The accuracy of the operational models can be improved by using observational data to shift the model state in a process called data assimilation. Here, a data assimilation approach using the temperature similarity to control the extent of extrapolation of point-like phenological observations is explored. A degree-day model is used to describe the spring phenology of the bird cherry Padus racemosa in the Baltic region in 2014. The model results are compared to phenological observations that are expressed on a continuous scale based on the BBCH code...
July 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28716012/case-reports-of-juvenile-gm1-gangliosidosisis-type-ii-caused-by-mutation-in-glb1-gene
#5
Parvaneh Karimzadeh, Samaneh Naderi, Farzaneh Modarresi, Hassan Dastsooz, Hamid Nemati, Tayebeh Farokhashtiani, Bibi Shahin Shamsian, Soroor Inaloo, Mohammad Ali Faghihi
BACKGROUND: Type II or juvenile GM1-gangliosidosis is an autosomal recessive lysosomal storage disorder, which is clinically distinct from infantile form of the disease by the lack of characteristic cherry-red spot and hepatosplenomegaly. The disease is characterized by slowly progressive neurodegeneration and mild skeletal changes. Due to the later age of onset and uncharacteristic presentation, diagnosis is frequently puzzled with other ataxic and purely neurological disorders. Up to now, 3-4 types of GM1-gangliosidosis have been reported and among them type I is the most common phenotype with the age of onset around 6 months...
July 17, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28715976/astrovirus-biology-and-pathogenesis
#6
Valerie Cortez, Victoria A Meliopoulos, Erik A Karlsson, Virginia Hargest, Cydney Johnson, Stacey Schultz-Cherry
Astroviruses are nonenveloped, positive-sense single-stranded RNA viruses that cause gastrointestinal illness. Although a leading cause of pediatric diarrhea, human astroviruses are among the least characterized enteric RNA viruses. However, by using in vitro methods and animal models to characterize virus-host interactions, researchers have discovered several important properties of astroviruses, including the ability of astrovirus capsid to act as an enterotoxin, disrupting the gut epithelial barrier. Improved animal models are needed to study this phenomenon, along with the pathogenesis of astroviruses, particularly in those strains that can cause extraintestinal disease...
July 17, 2017: Annual Review of Virology
https://www.readbyqxmd.com/read/28712082/biological-nutrient-recovery-from-culturing-of-pearl-gourami-trichogaster-leerii-by-cherry-tomato-solanum-lycopersicum-in-aquaponic-system
#7
Shima Makhdom, Seyed Pezhman Hosseini Shekarabi, Mehdi Shamsaie Mehrgan
The possibility of using different densities of cherry tomato as a bio-filter in a simple media-based aquaponic system to recycle nutrients from pearl gourami intensive culture wastewater was evaluated. Water quality parameters including total ammonia nitrogen (TAN), nitrite (NO2(-)), nitrate (NO3(-)), phosphate (PO4(3-)), pH, and dissolved oxygen (DO) were determined in outlet of the aquaponic system during a 60-day experimental period. Cherry tomato was planted at four densities of 0 (control), 3 (T1), 6 (T2), and 9 (T3) plants per aquaponic unit with a constant fish stock density...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28710709/psychological-factors-associated-with-painful-versus-non-painful-hiv-associated-sensory-neuropathy
#8
Prinisha Pillay, Antonia L Wadley, Catherine L Cherry, Alan S Karstaedt, Peter R Kamerman
HIV-associated sensory neuropathy (HIV-SN) is a common, and frequently painful complication of HIV, but factors that determine the presence of pain are unresolved. We investigated: (i) if psychological factors associated with painful (n = 125) versus non-painful HIV-SN (n = 72), and (ii) if pain and psychological factors affected quality of life (QoL). We assessed anxiety and depression using the Hopkins Symptoms Checklist-25. Pain catastrophizing and QoL were assessed using the Pain Catastrophizing Scale and Euroqol-5D, respectively...
July 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28706419/intestinal-anti-inflammatory-activity-of-ground-cherry-physalis-angulata-l-standardized-co2-phytopharmaceutical-preparation
#9
Luiz Domingues Almeida Junior, Ana Elisa Valencise Quaglio, Celso Acácio Rodrigues de Almeida Costa, Luiz Claudio Di Stasi
AIM: To investigate the effects of Ground Cherry (Physalis angulata L.) standardized supercritical CO2 extract in trinitrobenzenesulphonic acid (TNBS) model of rat intestinal inflammation. METHODS: The animals were divided into groups that received vehicle or P. angulata extract (PACO2) orally at the doses 25, 50 and 100 mg/kg daily by 5 d before TNBS damage. Protective effects of PACO2 were assessed by macroscopic analysis, biochemical determinations of the levels of myeloperoxidase (MPO), alkaline phosphatase (ALP), glutathione and cytokines (such as INF-γ, IL-1β, IL-6, IL-10 and TNF-α), gene expression evaluation (including Hsp70, heparanase, NF-κB, mitogen-activated protein kinases (Mapk) 1, 3, 6 and 9, and the mucins genes Muc 1, 2, 3 and 4) and histopathological studies using optical, and electronic (transmission and scanning) microscopy...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28699201/characterization-of-sugar-and-polyphenolic-diversity-in-floral-nectar-of-different-obla%C3%A4-inska-sour-cherry-clones
#10
Basem Guffa, Nebojša M Nedić, Dragana Č Dabić Zagorac, Tomislav B Tosti, Uroš M Gašić, Maja M Natić, Milica M Fotirić Akšić
'Oblačinska' sour cherry, an autochthonous cultivar, is the most planted cultivar in Serbian orchards. Since fruit trees in temperate zone reward insects by producing nectar which 'quality' affects the efficiency of insect pollination, the aim of this study was analyzing of sugars and polyphenolics in floral nectar of 16 'Oblačinska' sour cherry clones with different yielding potential. The contents of sugars and sugar alcohols were analyzed by ion chromatography, while polyphenolic profile was established using liquid chromatography - mass spectrometry technique (LC/MS)...
July 12, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28697060/mortality-among-hardmetal-production-workers-uk-cohort-and-nested-case-control-studies
#11
Damien M McElvenny, Laura A MacCalman, Anne Sleeuwenhoek, Alice Davis, Brian G Miller, Carla Alexander, Hilary Cowie, John W Cherrie, Kathleen J Kennedy, Nurtan A Esmen, Sarah D Zimmerman, Jeanine M Buchanich, Gary M Marsh
OBJECTIVE: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case-control study of lung cancer was undertaken. RESULTS: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low...
July 10, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28696985/tart-cherry-juice-in-athletes-a-literature-review-and-commentary
#12
Kenneth C Vitale, Shawn Hueglin, Elizabeth Broad
Tart cherry (TC) juice has many antioxidant and anti-inflammatory polyphenol compounds. TC lessens pain and accelerates strength recovery after exercise and decreases blood markers of inflammation/oxidative stress. These improvements occur in both strength and endurance exercise. TC supplementation may not be optimal during the adaptation/build stage of training. However, excessive inflammatory/oxidative stress during single-day intense training/competition or multiday tournaments may delay return to peak form...
July 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28693048/the-use-of-branched-endografts-for-the-aortic-arch-in-the-endovascular-era
#13
Rami O Tadros, Scott R Safir, Peter L Faries, Daniel K Han, Rajiv K Chander, Cherrie Z Abraham, Michael L Marin, Allan S Stewart
The endovascular realm has steadily increased its footing in the treatment of the aorta and all of its territories since the foundational case in 1990 by Parodi. The aortic arch, however, continues to be one of the last bastions for treatment via open surgery, which remains the gold standard. Significant comorbidity and prior cardiac surgery prevent open surgery from being the only preferred option, allowing novel endovascular procedures to be considered. Since 1999, more advanced endovascular systems have been created by companies such as Cook Medical, Bolton Medical, Medtronic, Endospan, Gore Medical, and, recently, Kawasumi...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28688850/crop-associated-virus-reduces-the-rooting-depth-of-non-crop-perennial-native-grass-more-than-non-crop-associated-virus-with-known-viral-suppressor-of-rna-silencing-vsr
#14
Carolyn M Malmstrom, Patrick Bigelow, Piotr Trebicki, Anna K Busch, Colleen Friel, Ellen Cole, Heba Abdel-Azim, Colin Phillippo, Helen M Alexander
As agricultural acreage expanded and came to dominate landscapes across the world, viruses gained opportunities to move between crop and wild native plants. In the Midwestern USA, virus exchange currently occurs between widespread annual Poaceae crops and remnant native perennial prairie grasses now under consideration as bioenergy feedstocks. In this region, the common aphid species Rhopalosiphum padi L. (the bird cherry-oat aphid) transmits several virus species in the family Luteoviridae, including Barley yellow dwarf virus (BYDV-PAV, genus Luteovirus) and Cereal yellow dwarf virus (CYDV-RPV and -RPS, genus Polerovirus)...
July 5, 2017: Virus Research
https://www.readbyqxmd.com/read/28684831/dental-radiography-cherry-picking-evidence
#15
M Armstrong, R Ladwa, A Lockyer
No abstract text is available yet for this article.
July 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28678785/dependency-of-a-therapy-resistant-state-of-cancer-cells-on-a-lipid-peroxidase-pathway
#16
Vasanthi S Viswanathan, Matthew J Ryan, Harshil D Dhruv, Shubhroz Gill, Ossia M Eichhoff, Brinton Seashore-Ludlow, Samuel D Kaffenberger, John K Eaton, Kenichi Shimada, Andrew J Aguirre, Srinivas R Viswanathan, Shrikanta Chattopadhyay, Pablo Tamayo, Wan Seok Yang, Matthew G Rees, Sixun Chen, Zarko V Boskovic, Sarah Javaid, Cherrie Huang, Xiaoyun Wu, Yuen-Yi Tseng, Elisabeth M Roider, Dong Gao, James M Cleary, Brian M Wolpin, Jill P Mesirov, Daniel A Haber, Jeffrey A Engelman, Jesse S Boehm, Joanne D Kotz, Cindy S Hon, Yu Chen, William C Hahn, Mitchell P Levesque, John G Doench, Michael E Berens, Alykhan F Shamji, Paul A Clemons, Brent R Stockwell, Stuart L Schreiber
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with resistance to multiple treatment modalities across diverse cancer lineages, but the mechanistic underpinning for this state has remained incompletely understood. Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid-peroxidase pathway that protects against ferroptosis, a non-apoptotic form of cell death induced by the build-up of toxic lipid peroxides...
July 5, 2017: Nature
https://www.readbyqxmd.com/read/28677202/dreadd-induced-silencing-of-the-medial-amygdala-reduces-the-preference-for-male-pheromones-and-the-expression-of-lordosis-in-estrous-female-mice
#17
Elizabeth A McCarthy, Arman Maqsudlu, Matthew Bass, Sofia Georghiou, James A Cherry, Michael J Baum
Sexually naïve estrous female mice seek out male urinary pheromones; however, they initially display little receptive (lordosis) behavior in response to male mounts. Vomeronasal - accessory olfactory bulb inputs to the medial amygdala (Me) regulate courtship in female rodents. We used a reversible inhibitory chemogenetic technique (Designer Receptors Exclusively Activated by Designer Drugs; DREADDs) to assess the contribution of Me signaling to females' preference for male pheromones and improvement in receptivity normally seen with repeated testing...
July 5, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28674238/characterization-of-duck-anas-platyrhynchos-mhc-class-i-gene-in-two-duck-lines
#18
Lin Zhang, Wei-Jie Liu, Jia-Qiang Wu, Min-Li Xu, Zheng-Jie Kong, Yan-Yan Huang, Shao-Hua Yang
To enrich gene polymorphism ofDuMHCI and provide data for further studies on disease resistance, 14DuMHCI genes from Weishan Ma duck and Cherry Valley duck were cloned, and their characterization were investigated. The overall conservation of the 14 alleles could be observed within the sequences, and relative conservation were also displayed in the peptide-binding domain and CD8 interaction sites. Based on full-length amino acid homology, MHC class I from different duck lines could be divided into 13 gene groups and three novel gene groups existed...
June 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28666622/joint-icman-and-iuphar-natural-products-section-meeting-aberdeen-uk-27-29-th-september-2017
#19
EDITORIAL
Yongxiang Zhang, Michael Spedding, Cherry Wainwright, Valérie Schini-Kerth, Giovanna Bermano
This special issue of Biochemical Pharmacology contains proceedings of a joint conference sponsored by the Natural Products Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the International Conference on the Mechanism of Action of Nutraceuticals (ICMAN), an organization dedicated to defining actions and clinical benefits of pharmaceuticals and nutraceuticals. Entitled "From Nutraceuticals to Pharmaceuticals: Common Challenges and Approaches", the conference was held in Aberdeen UK in September, 2017...
June 27, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28662619/dsm-5-diagnosis-of-internet-gaming-disorder-some-ways-forward-in-overcoming-issues-and-concerns-in-the-gaming-studies-field
#20
Daria J Kuss, Mark D Griffiths, Halley M Pontes
Background and aims The current DSM-5 diagnosis of Internet Gaming Disorder (IGD; American Psychiatric Association [APA], 2013) has led to a number of issues and concerns that we highlighted in our recent paper (Kuss, Griffiths, & Pontes, 2017). Experts in the field responded to our evaluation of these issues resulting in six commentaries. Methods In this paper, we offer responses to the six commentaries to move the scientific field forward. All of the responses to our original paper highlighted many conceptual, theoretical, and/or methodological problems with the proposed IGD diagnosis as outlined in the DSM-5...
June 1, 2017: Journal of Behavioral Addictions
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