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https://www.readbyqxmd.com/read/27904404/phenolic-composition-antioxidant-capacity-and-in-vitro-cytotoxicity-assessment-of-fruit-wines
#1
Ana Ljevar, Natka Ćurko, Marina Tomašević, Kristina Radošević, Višnja Gaurina Srček, Karin Kovačević Ganić
Fruit wines contain a wide range of phenolic compounds with biological effects, but their composition and potential benefits to human health have been studied to the much lesser extent compared to grape wines. The aim of this research is to study the phenolic profile of different types of fruit wines and to evaluate their antioxidant and biological potential. Commercially available fruit wines from blackberry, cherry, raspberry, blackcurrant, strawberry and apple produced in Croatia were analyzed. To the best of our knowledge, this study represents the first comprehensive screening of Croatian fruit wines...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27903500/primary-resistance-to-pd-1-blockade-mediated-by-jak%C3%A2-mutations
#2
Daniel Sanghoon Shin, Jesse M Zaretsky, Helena Escuin-Ordinas, Angel Garcia-Diaz, Siwen Hu-Lieskovan, Anusha Kalbasi, Catherine S Grasso, Willy Hugo, Salemiz Sandoval, Davis Y Torrejon, Nicolaos Palaskas, Gabriel Abril Rodriguez, Giulia Parisi, Ariel Azhdam, Bartosz Chmielowski, Grace Cherry, Elizabeth Seja, Beata Berent-Maoz, I Peter Shintaku, Dung Thi Le, Drew M Pardoll, Luis A Diaz, Paul C Tumeh, Thomas G Graeber, Roger S Lo, Begoña Comin-Anduix, Antoni Ribas
Loss of function mutations in JAK½ can lead to acquired resistance to anti-programmed death protein 1 (PD-1) therapy. We reasoned they may also be involved in primary resistance to anti-PD-1 therapy. JAK½ inactivating mutations were noted in tumor biopsies of 1 of 23 patients with melanoma and in 1 of 16 patients with mismatch repair deficient colon cancer treated with PD-1 blockade. Both cases had a high mutational load but did not respond to anti-PD-1 therapy. Two out of 48 human melanoma cell lines had JAK½ mutations, which led to lack of PD-L1 expression upon interferon gamma exposure mediated by inability to signal through the interferon gamma receptor pathway...
November 30, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27895565/challenges-to-the-pair-bond-neural-and-hormonal-effects-of-separation-and-reunion-in-a-monogamous-primate
#3
Katie Hinde, Chelsea Muth, Nicole Maninger, Benjamin J Ragen, Rebecca H Larke, Michael R Jarcho, Sally P Mendoza, William A Mason, Emilio Ferrer, Simon R Cherry, Marina L Fisher-Phelps, Karen L Bales
Social monogamy at its most basic is a group structure in which two adults form a unit and share a territory. However, many socially monogamous pairs display attachment relationships known as pair bonds, in which there is a mutual preference for the partner and distress upon separation. The neural and hormonal basis of this response to separation from the adult pair mate is under-studied. In this project, we examined this response in male titi monkeys (Callicebus cupreus), a socially monogamous New World primate...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27895542/effect-of-tart-cherry-juice-on-recovery-and-next-day-performance-in-well-trained-water-polo-players
#4
Rachel McCormick, Peter Peeling, Martyn Binnie, Brian Dawson, Marc Sim
BACKGROUND: Tart Montmorency cherries contain high concentrations of phytochemicals and anthocyanins, which have recently been linked to improved athletic recovery and subsequent performance. To date however, previous work reporting promising results has focused on land-based endurance sports, with any potential benefits to team sports remaining unknown. As such, this investigation set-out to examine the effect of supplemental tart cherry juice (CJ) on recovery and next day athletic performance in highly-trained water-based team sport athletes over seven days...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27891751/simultaneous-determination-of-pyrifluquinazon-and-its-main-metabolite-in-fruits-and-vegetables-by-using-quechers-hplc-ms-ms
#5
Xiangwei You, Chengcheng Sui, Yiqiang Li, Xiuguo Wang
A rapid, reliable and sensitive method is reported for the simultaneous analysis of pyrifluquinazon and its main metabolite NNI-0101-1H in fruits (strawberry and cherry) and vegetables (cucumber and tomato) using high-performance liquid chromatography coupled with tandem mass spectrometry. A modified quick, easy, cheap, effective, rugged and safe procedure was used for the sample pre-preparation. The target analytes were extracted with acetonitrile and then cleaned up using dispersive solid phase extraction procedure with primary secondary amine...
November 28, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27890427/internal-and-external-generalizability-of-temporal-dose-response-relationships-for-xerostomia-following-imrt-for-head-and-neck-cancer
#6
Maria Thor, Adepitan A Owosho, Haley D Clark, Jung Hun Oh, Nadeem Riaz, Allan Hovan, Jillian Tsai, Steven D Thomas, Sae Hee K Yom, Jonn S Wu, Joseph M Huryn, Vitali Moiseenko, Nancy Y Lee, Cherry L Estilo, Joseph O Deasy
BACKGROUND AND PURPOSE: To study internal and external generalizability of temporal dose-response relationships for xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer, and to investigate potential amendments of the QUANTEC guidelines. MATERIAL AND METHODS: Objective xerostomia was assessed in 121 patients (nCohort1=55; nCohort2=66) treated to 70Gy@2Gy in 2006-2015. Univariate and multivariate analyses (UVA, MVA with 1000 bootstrap populations) were conducted in Cohort1, and generalizability of the best-performing MVA model was investigated in Cohort2 (performance: AUC, p-values, and Hosmer-Lemeshow p-values (pHL))...
November 24, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27884761/assessment-of-the-motivation-to-use-artificial-sweetener-among-individuals-with-an-eating-disorder
#7
Janet Schebendach, Diane A Klein, Laurel E S Mayer, Evelyn Attia, Michael J Devlin, Richard W Foltin, B Timothy Walsh
Eating disorders are associated with a range of abnormalities in eating behavior. Some individuals consume large amounts of non-caloric artificial sweeteners, suggesting abnormalities in appetitive responding. The current study aimed to quantify hedonic and motivating effects of artificial sweetener in individuals with and without an eating disorder. Two laboratory studies were conducted. Hedonic preference was estimated using the number of artificial sweetener packets (0-10) added to unsweetened cherry flavored Kool-Aid (study 1)...
November 21, 2016: Appetite
https://www.readbyqxmd.com/read/27882347/ml372-blocks-smn-ubiquitination-and-improves-spinal-muscular-atrophy-pathology-in-mice
#8
Mahlet B Abera, Jingbo Xiao, Jonathan Nofziger, Steve Titus, Noel Southall, Wei Zheng, Kasey E Moritz, Marc Ferrer, Jonathan J Cherry, Elliot J Androphy, Amy Wang, Xin Xu, Christopher Austin, Kenneth H Fischbeck, Juan J Marugan, Barrington G Burnett
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and one of the leading inherited causes of infant mortality. SMA results from insufficient levels of the survival motor neuron (SMN) protein, and studies in animal models of the disease have shown that increasing SMN protein levels ameliorates the disease phenotype. Our group previously identified and optimized a new series of small molecules, with good potency and toxicity profiles and reasonable pharmacokinetics, that were able to increase SMN protein levels in SMA patient-derived cells...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27878597/the-sweet-cherry-prunus-avium-flowering-locus-t-gene-is-expressed-during-floral-bud-determination-and-can-promote-flowering-in-a-winter-annual-arabidopsis-accession
#9
Antonia Yarur, Esteban Soto, Gabriel León, Andrea Miyasaka Almeida
FT gene is expressed in leaves and buds and is involved in floral meristem determination and bud development in sweet cherry. In woody fruit perennial trees, floral determination, dormancy and bloom, depends on perception of different environmental and endogenous cues which converge to a systemic signaling gene known as FLOWERING LOCUS T (FT). In long-day flowering plants, FT is expressed in the leaves on long days. The protein travels through the phloem to the shoot apical meristem, where it induces flower determination...
December 2016: Plant Reproduction
https://www.readbyqxmd.com/read/27877156/a-chitosan-coating-containing-essential-oil-from-origanum-vulgare-l-to-control-postharvest-mold-infections-and-keep-the-quality-of-cherry-tomato-fruit
#10
Tainá A Barreto, Sonalle C A Andrade, Janeeyre F Maciel, Narciza M O Arcanjo, Marta S Madruga, Bruno Meireles, Ângela M T Cordeiro, Evandro L Souza, Marciane Magnani
The efficacy of an edible chitosan coating (CHI; 4 mg/mL) and Origanum vulgare L. essential oil (OVEO; 1.25 μL/mL) for maintaining the quality of cherry tomato fruit during storage at room (25°C; 12 days) and cold (12°C; 24 days) temperatures was assessed. CHI and OVEO in combination showed in vitro fungicidal effects against R. stolonifer and Aspergillus niger. CHI-OVEO coating reduced the incidence of black mold and soft rot caused by these fungi in artificially contaminated cherry tomato fruit during storage at both temperatures...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27872261/comorbid-diabetes-and-depression-in-a-national-sample-of-adults-with-psychosis
#11
Debra L Foley, Andrew Mackinnon, Vera A Morgan, David J Castle, Anna Waterreus, Cherrie A Galletly
OBJECTIVE: People with psychosis have an elevated risk of depression and diabetes but no large-scale study has characterized their relationship. We aimed to assess this association and to evaluate possible explanatory factors. METHODS: Analysis of cross-sectional data from a national sample of 1155 people with psychosis who gave a fasting blood sample and could be tested for diabetes mellitus. The association between current diabetes mellitus and current depression was estimated using logistic regression, adjusted for age, sex and current psychotropic medication...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27871342/campbell-de-morgan-spot-better-known-as-a-cherry-angioma
#12
EDITORIAL
Ayse Serap Karadag, Lawrence Charles Parish
No abstract text is available yet for this article.
2016: Skinmed
https://www.readbyqxmd.com/read/27860281/counting-up-the-risks-how-common-are-risk-factors-for-morbidity-and-mortality-in-young-people-with-psychosis
#13
Lisa Anne Hahn, Andrew Mackinnon, Debra L Foley, Vera A Morgan, Anna Waterreus, Gerald F Watts, David J Castle, Dennis Liu, Cherrie A Galletly
BACKGROUND: This study examined the prevalence of risk factors for cardiovascular (CV)-related morbidity and mortality in young people with psychosis aged 18 to 24 years. METHODS: The study included 132 people aged 18 to 24 years who participated in the 2010 second Australian national survey of people living with psychosis. The 2009 World Health Organisation (WHO) Global Health Risks report was used as a framework to determine which specific risk factors were present in each in these young people...
November 17, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27859276/urological-complications-after-cystectomy-as-part-of-pelvic-exenteration-are-higher-than-that-after-cystectomy-for-primary-bladder-malignancy
#14
Kilian G M Brown, Michael J Solomon, Edward R Latif, Cherry E Koh, Arthur Vasilaras, David Eisinger, Paul Sved
BACKGROUND: Total cystectomy and subsequent reconstruction of the urinary tract may be required for primary malignancy of the bladder, or in the context of multi-visceral resection for more advanced pelvic tumors. Complications following urinary diversion are a major source of morbidity, particularly in pelvic exenteration (PE) patients. METHODS: All patients who underwent radical cystectomy alone or during PE at a single tertiary referral centre between 2008 and 2014 were reviewed...
November 18, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27854359/commentary-on-the-decision-of-the-american-board-of-medical-genetics-and-genomics-to-create-a-24-month-specialty-of-laboratory-genetics-and-genomics
#15
Frederick R Bieber, Athena M Cherry, Beverly S Emanuel, Uta Francke, H Eugene Hoyme, Laird G Jackson, Cynthia C Morton, Maximillian Muenke, Cynthia M Powell, Hope H Punnett, P Nagesh Rao, Stuart Schwartz, Roger E Stevenson, Daniel L Van Dyke
Genet Med advance online publication 17 November 2016Genetics in Medicine (2016); doi:10.1038/gim.2016.171.
November 17, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27845940/citations-prize-2016
#16
Simon Cherry, Maggie Simmons
No abstract text is available yet for this article.
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27843128/the-impact-of-crunchy-wednesdays-on-happy-meal-fruit-orders-analysis-of-sales-data-in-france-2009-2013
#17
Adam Drewnowski, Serge Michels, Diane Leroy
OBJECTIVE: Beginning in September, 2010, all McDonald's restaurants in France offered free fruit with every Happy Meal sold on the first Wednesday of the month. Sales data were used to determine the impact of free fruit promotion on the proportion of regular Happy Meal fruit desserts sold. METHODS: Trend analyses examined the proportion of fruit desserts for 2009-2013. Analyses also compared fruit orders on Crunchy Wednesdays with other weekdays. RESULTS: Happy Meal fruit desserts rose from 14...
November 11, 2016: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/27835660/two-fgleu2-genes-with-different-roles-in-leucine-biosynthesis-and-infection-related-morphogenesis-in-fusarium-graminearum
#18
Xin Liu, Qi Han, Jian Wang, Xin Wang, Jianhong Xu, Jianrong Shi
3-isopropylmalate dehydrogenase (IPMD) encoded by LEU2 is a key enzyme in leucine (Leu) biosynthetic pathway. Analysis of the genome sequence of Fusarium graminearum revealed two paralogous LEU2 genes (designated as FgLEU2A and FgLEU2B) in this fungus and the deduced amino acid sequences of FgLeu2A and FgLeu2B share 45% identity. Targeted disruption of individual FgLEU2A/B gene in F. graminearum assigned a more crucial role of FgLeu2A in Leu biosynthesis as disruption of FgLEU2A resulted in mutant (ΔFgLeu2A-10) that was Leu-auxotrophic and could not grow in minimal medium limited for amino acids, whereas FgLEU2B deletion mutant ΔFgLeu2B-2 was morphologically indistinguishable from the wild type strain PH-1...
2016: PloS One
https://www.readbyqxmd.com/read/27829575/efficacy-of-web-based-collection-of-strength-based-testimonials-for-text-message-extension-of-youth-suicide-prevention-program-randomized-controlled-experiment
#19
Phyo Thiha, Anthony R Pisani, Kunali Gurditta, Erin Cherry, Derick R Peterson, Henry Kautz, Peter A Wyman
BACKGROUND: Equipping members of a target population to deliver effective public health messaging to peers is an established approach in health promotion. The Sources of Strength program has demonstrated the promise of this approach for "upstream" youth suicide prevention. Text messaging is a well-established medium for promoting behavior change and is the dominant communication medium for youth. In order for peer 'opinion leader' programs like Sources of Strength to use scalable, wide-reaching media such as text messaging to spread peer-to-peer messages, they need techniques for assisting peer opinion leaders in creating effective testimonials to engage peers and match program goals...
November 9, 2016: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/27829096/cognitive-subtypes-of-schizophrenia-characterized-by-differential-brain-volumetric-reductions-and-cognitive-decline
#20
Danielle Weinberg, Rhoshel Lenroot, Isabella Jacomb, Katherine Allen, Jason Bruggemann, Ruth Wells, Ryan Balzan, Dennis Liu, Cherrie Galletly, Stanley V Catts, Cynthia Shannon Weickert, Thomas W Weickert
Importance: Cognitively distinct subgroups of schizophrenia have been defined based on premorbid and current IQ, but little is known about the neuroanatomical differences among these cognitive subgroups. Objectives: To confirm previous findings related to IQ-based subgroups of patients with schizophrenia in an independent sample and extend those findings to determine the extent to which brain volumetric differences correspond to the IQ-based subgroups. Design, Setting, and Participants: A total of 183 participants were assessed at the outpatient settings of Neuroscience Research Australia and Lyell McEwin Hospital from September 22, 2009, to August 1, 2012...
November 9, 2016: JAMA Psychiatry
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