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https://www.readbyqxmd.com/read/29473235/caveolin-3-dependent-loss-of-t-tubular-i-ca-during-hypertrophy-and-heart-failure-in-mice
#1
Simon M Bryant, Cherrie H T Kong, Judy J Watson, Hanne C Gadeberg, Andrew F James, Mark B Cannell, Clive H Orchard
BACKGROUND: Previous work has shown redistribution of L-type Ca current (ICa ) from the t-tubules to the surface membrane of rat ventricular myocytes following myocardial infarction. However, whether this occurs in all species and in response to other insults, the relationship of this redistribution to the severity of the pathology, and the underlying mechanism, are unknown. We have therefore investigated the response of mouse hearts and myocytes to pressure overload induced by transverse aortic constriction (TAC)...
February 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29471427/health-and-work-in-women-and-men-in-the-welding-and-electrical-trades-how-do-they-differ
#2
Nicola Cherry, Victoria Arrandale, Jeremy Beach, Jean-Michel F Galarneau, Antonia Mannette, Laura Rodgers
Objectives: There is little information on how work tasks, demands, and exposures differ between women and men in nominally the same job. This is critical in setting workplace standards that will protect the health of both men and those women moving into less traditional work roles. Information used in setting standards is currently based almost entirely on male workers. This paper describes differences in work and health, and the relation between them, in women and men who have undergone the same trade training for the welding or electrical trades...
February 17, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29467934/effects-of-stc1-overexpression-on-tumorigenicity-and-metabolism-of-hepatocellular-carcinoma
#3
Cherry Ct Leung, Chris Kc Wong
Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. Using clinicopathological data, we previously reported that a greater expression of STC1 in hepatocellular carcinoma (HCC) was significantly correlated with smaller tumor size. The underlying mechanism on the correlation is not known. In this study, using a metastatic HCC cell-line (MHCC-97L, P) and lentiviral vector mediated-STC1 overexpression, the inoculation of STC1-overexpressing MHCC-97L (S1) cells in a nude mice xenograft model demonstrated reductions in tumor mass and volume...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29466279/examination-of-behavioral-social-and-environmental-contextual-influences-on-sexually-transmitted-infections-in-at-risk-urban-adolescents-and-young-adults
#4
Cherrie B Boyer, Olga J Santiago Rivera, Danielle M Chiaramonte, Jonathan M Ellen
BACKGROUND: Despite the large body of extant literature on sexually transmitted infections (STIs) in adolescents and young adults (AYAs), more research on social and environmental contextual factors is needed. Also, further examination of STI indicators by gender remains a critical area of research focus. METHODS: Anonymous survey data were collected using ACASIs in community venues in urban, low-income, STI prevalent, U.S. neighborhoods to reach AYAs, aged 12-24 years...
February 21, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29464997/the-discovery-of-novel-hdac3-inhibitors-via-virtual-screening-and-in-vitro-bioassay
#5
Jie Xia, Huabin Hu, Wenjie Xue, Xiang Simon Wang, Song Wu
Histone deacetylase 3 (HDAC3) is a potential target for the treatment of human diseases such as cancers, diabetes, chronic inflammation and neurodegenerative diseases. Previously, we proposed a virtual screening (VS) pipeline named "Hypo1_FRED_SAHA-3" for the discovery of HDAC3 inhibitors (HDAC3Is) and had thoroughly validated it by theoretical calculations. In this study, we attempted to explore its practical utility in a large-scale VS campaign. To this end, we used the VS pipeline to hierarchically screen the Specs chemical library...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29462418/what-should-we-tell-shift-workers-to-do-to-reduce-their-cancer-risk
#6
Damien M McElvenny, Joanne O Crawford, John W Cherrie
No abstract text is available yet for this article.
February 16, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29460198/collaborative-environmental-dna-sampling-from-petal-surfaces-of-flowering-cherry-cerasus-%C3%A3-yedoensis-somei-yoshino-across-the-japanese-archipelago
#7
Tazro Ohta, Takeshi Kawashima, Natsuko O Shinozaki, Akito Dobashi, Satoshi Hiraoka, Tatsuhiko Hoshino, Keiichi Kanno, Takafumi Kataoka, Shuichi Kawashima, Motomu Matsui, Wataru Nemoto, Suguru Nishijima, Natsuki Suganuma, Haruo Suzuki, Y-H Taguchi, Yoichi Takenaka, Yosuke Tanigawa, Momoka Tsuneyoshi, Kazutoshi Yoshitake, Yukuto Sato, Riu Yamashita, Kazuharu Arakawa, Wataru Iwasaki
Recent studies have shown that environmental DNA is found almost everywhere. Flower petal surfaces are an attractive tissue to use for investigation of the dispersal of environmental DNA in nature as they are isolated from the external environment until the bud opens and only then can the petal surface accumulate environmental DNA. Here, we performed a crowdsourced experiment, the "Ohanami Project", to obtain environmental DNA samples from petal surfaces of Cerasus × yedoensis 'Somei-yoshino' across the Japanese archipelago during spring 2015...
February 19, 2018: Journal of Plant Research
https://www.readbyqxmd.com/read/29452629/continuous-betadine-bacitracin-irrigation-for-vascular-graft-infections-a-case-series
#8
David V Strider, Catherine R Ratliff, Kenneth J Cherry, Gilbert R Upchurch
The aim of the study was to conduct a retrospective chart review of patients who underwent betadine/bacitracin continuous irrigation (BBCI) for vascular graft infections (VGIs) to review its use as a treatment option. A retrospective chart review from 2013 to 2017 was conducted of patients with VGIs that were treated with BBCI postremoval of the infected graft. The BBCI is a continuous infusion of 0.25% betadine in normal saline at 0.3 mL/kg/h for 48 hours then followed by bacitracin infusion with a concentration of 50,000 units bacitracin/per liter normal saline at 0...
March 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29449955/prospects-for-precision-medicine-in-glomerulonephritis-treatment
#9
REVIEW
Yulu Cherry Liu, Justin Chun
Background: Glomerulonephritis (GN) consists of a group of kidney diseases that are categorized based on shared histopathological features. The current classifications for GN make it difficult to distinguish the individual variability in presentation, disease progression, and response to treatment. GN is a significant cause of end-stage renal disease (ESRD), and improved therapies are desperately needed because current immunosuppressive therapies sometimes lack efficacy and can lead to significant toxicities...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29448922/a-randomised-control-crossover-trial-of-a-theory-based-intervention-to-improve-sun-safe-and-healthy-behaviours-in-construction-workers-study-protocol
#10
Amanda Nioi, Charlotte Wendelboe-Nelson, Sue Cowan, Hilary Cowie, Shahzad Rashid, Peter Ritchie, Mark Cherrie, Terry C Lansdown, John W Cherrie
BACKGROUND: Exposure to sunlight can have both positive and negative health impacts. Excessive exposure to ultra-violet (UV) radiation from the sun can cause skin cancer, however insufficient exposure to sunlight has a detrimental effect on production of Vitamin D. In the construction industry there are onsite proactive behaviours for safety, but sun-safety remains a low priority. There is limited research on understanding the barriers to adopting sun-safe behaviours and the association this may have with Vitamin D production...
February 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29442609/caveat-emptor-folate-in-unipolar-depressive-illness-a-systematic-review-and-meta-analysis
#11
Emmert Roberts, Ben Carter, Allan H Young
BACKGROUND: International guideline recommendations for the use of folate and its derivatives in the treatment of unipolar depressive disorders are confused and contradictory, perhaps reflecting wide variations in the underpinning evidence base. INTRODUCTION: We discuss differing methods of evidence synthesis in the formulation of international guideline recommendations. As an example we evaluated the efficacy of folate and its derivatives in unipolar depression via systematic review and meta-analysis...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29440217/using-big-data-to-improve-cardiovascular-care-and-outcomes-in-china-a-protocol-for-the-chinese-electronic-health-records-research-in-yinzhou-cherry-study
#12
Hongbo Lin, Xun Tang, Peng Shen, Dudan Zhang, Jinguo Wu, Jingyi Zhang, Ping Lu, Yaqin Si, Pei Gao
INTRODUCTION: Data based on electronic health records (EHRs) are rich with individual-level longitudinal measurement information and are becoming an increasingly common data source for clinical risk prediction worldwide. However, few EHR-based cohort studies are available in China. Harnessing EHRs for research requires a full understanding of data linkages, management, and data quality in large data sets, which presents unique analytical opportunities and challenges. The purpose of this study is to provide a framework to establish a uniquely integrated EHR database in China for scientific research...
February 12, 2018: BMJ Open
https://www.readbyqxmd.com/read/29439411/bioactive-compounds-in-cornelian-cherry-vinegars
#13
Joanna Kawa-Rygielska, Kinga Adamenko, Alicja Z Kucharska, Narcyz Piórecki
We analyzed the effect of Cornelian cherry varieties differing in fruit color ('Yantaryi'-yellow fruits, 'Koralovyi'-coral fruits, 'Podolski'-red fruits) and the production method on the physicochemical and antioxidative properties of Cornelian cherry vinegars, and on their content of iridoids and polyphenols. Acetic fermentation was conducted by two methods: I) single-stage (spontaneous) acetic fermentation, without inoculation with microorganisms, and II) two-stage fermentation in which the first stage involved the use of Saccharomyces bayanus -Safspirit fruit yeast for alcoholic fermentation, and the second one included spontaneous acetic fermentation...
February 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29438537/irrigation-and-grass-cover-effects-on-pupal-survival-rates-in-soil-and-adult-emergence-patterns-of-rhagoletis-indifferens-diptera-tephritidae
#14
Wee L Yee, Peter S Chapman
Western cherry fruit fly, Rhagoletis indifferens (Curran; Diptera: Tephritidae), occurs in unmanaged cherries (Prunus spp.) across dry climates in Washington State and other regions in western United States and Canada. To help explain the fly's distribution in arid climates, we determined the effects of adding water to bare and grass-covered soils on pupal survival rates and adult emergence patterns of R. indifferens in central Washington. Water was added ('irrigated') or not to bare soil and grass-covered soil in cylinders pressed into the ground...
February 9, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29428219/capillary-liquid-chromatography-ion-trap-mass-spectrometry-methodology-for-the-simultaneous-quantification-of-four-angiotensin-converting-enzyme-inhibitory-peptides-in-prunus-seed-hydrolysates
#15
Estefanía González-García, María Concepción García, María Luisa Marina
Prunus genus fruit seeds are sources of highly angiotensin-I-converting enzyme (ACE)-inhibitory peptides. The presence of peptides IYSPH, IYTPH, IFSPR, and VAIP seems to be related to this activity but no previous work has demonstrated the direct relationship between the concentration of these peptides and the antihypertensive activity of hydrolysates. This work describes the development of a method for the quantification of these peptides in Prunus seeds hydrolysates based on capillary liquid chromatography-IT-MS/MS...
February 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29427619/the-association-of-aortic-valve-pathology-with-renal-resistive-index-as-a-kidney-injury-biomarker
#16
Benjamin Y Andrew, Anne D Cherry, Jennifer N Hauck, Alina Nicoara, Cory D Maxwell, Ryan M Konoske, Annemarie Thompson, Lakshmi D Kartha, Madhav Swaminathan, Mark Stafford-Smith
BACKGROUND: Acute kidney injury (AKI) is a common serious complication following cardiac surgery. Doppler-determined renal resistive index (RRI) is a promising early AKI biomarker in this population. However, the relationship between aortic valve pathology (insufficiency and/or stenosis) and RRI is unknown. This study aimed to investigate RRI variability related to aortic valve pathology. METHODS: In a retrospective review of cardiac surgery patients, RRI and aortic valve pathology were assessed prior to cardiopulmonary bypass using transesophageal echocardiography...
February 7, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29421853/anti-photoaging-effect-of-prunus-yeonesis-blossom-extract-via-inhibition-of-mapk-ap-1-and-regulation-of-the-tgf-%C3%AE-i-smad-and-nrf2-are-signaling-pathways
#17
Lu Li, Eunson Hwang, Hien T T Ngo, Pei Lin, Wei Gao, Ying Liu, Tae-Hoo Yi
Cherry blossoms have attracted attention as an ingredient with potential for use in skincare products. However, no skin photoaging-related research has been performed with this plant. In the present study, cherry blossom extract (CBE) at 1, 10, and 100 μg/mL was investigated for its skin anti-photoaging effects in UVB-irradiated normal human dermal fibroblasts (NHDF) cells in vitro. Our results showed that CBE markedly increased type I procollagen during UVB exposure via two pathways. Firstly, transcription activator protein-1 expression and MAP kinases were downregulated, consequently reducing the production of matrix metalloproteinase (MMP)-1 and MMP-3...
February 8, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29420427/the-price-we-pay-for-radical-curative-pelvic-exenterations-prevalence-and-management-of-pain
#18
Jessica Shao-Yeung Lim, Cherry E Koh, Hannah Liu, Michael J Solomon, Charlotte S H Johnstone
BACKGROUND: Pelvic exenterations are extensive surgical procedures for locally advanced or recurrent malignancies of the pelvis. However, this is often at the cost of significant morbidity due to perioperative pain, which has been poorly studied. OBJECTIVE: This study aims to review perioperative pain management in patients undergoing pelvic exenteration. DESIGN: This is a retrospective review of patients undergoing pelvic exenteration between January 2013 and December 2014...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29419483/development-and-evaluation-of-mini-explorer-a-long-axial-field-of-view-pet-scanner-for-non-human-primate-imaging
#19
Eric Berg, Xuezhu Zhang, Julien Bec, Martin Stefan Judenhofer, Brijesh Patel, Qiyu Peng, Maciej Kapusta, Matthias Schmand, Mike Casey, Alice F Tarantal, J Qi, Ramsey Badawi, Simon R Cherry
Rationale: We describe a long axial field-of-view (FOV) positron emission tomography (PET) scanner for high sensitivity and total-body imaging of non-human primates, and present the physical performance and first phantom and animal imaging results. Methods: The mini-EXPLORER was built using the components of a clinical scanner (Siemens mCT) reconfigured with a detector ring diameter of 43.5 cm and axial length of 45.7 cm. NEMA NU-2 and NU-4 phantoms were used to measure sensitivity and count rate performance...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29417853/challenges-in-the-diagnosis-of-acute-cyanide-poisoning
#20
J L Parker-Cote, J Rizer, J P Vakkalanka, S V Rege, C P Holstege
OBJECTIVE: The aim of this systematic review was to identify isolated acute cyanide poison cases and to identify reported signs, symptoms, and laboratory findings. METHODS: We searched MEDLINE, Cochrane Reviews, and Web of Science case reports and series using a number of MeSH descriptors pertaining to cyanide, toxicity, and poisonings. We excluded studies on plants, laboratory analyses, smoke inhalation poisonings, animals as well as non-English language articles and those in which data were not available...
February 8, 2018: Clinical Toxicology
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