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https://www.readbyqxmd.com/read/27919627/randomized-phase-2-trial-of-pharmacodynamic-separation-of-pemetrexed-and-intercalated-erlotinib-versus-pemetrexed-alone-for-advanced-nonsquamous-non-small-cell-lung-cancer
#1
Tianhong Li, Bilal Piperdi, William V Walsh, Mimi Kim, Laurel A Beckett, Rasim Gucalp, Missak Haigentz, Venu G Bathini, Huiyu Wen, Kaili Zhou, Patricia B Pasquinelli, Srikanth Gajavelli, Meera Sreedhara, Xianhong Xie, Primo N Lara, David R Gandara, Roman Perez-Soler
BACKGROUND: Pharmacodynamic separation of pemetrexed and erlotinib avoids negative cellular interactions and results in antitumor synergy in erlotinib-resistant non-small-cell lung cancer (NSCLC) cells, independent of EGFR (epidermal growth factor receptor) genotype. PATIENTS AND METHODS: Patients with platinum-treated metastatic nonsquamous NSCLC were randomly assigned 1:2 to pemetrexed alone (500 mg/m(2) provided intravenously on day 1) or pemetrexed followed by erlotinib (150 mg provided orally once daily on days 2-17) every 21 days...
October 28, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27916075/-effect-of-single-nucleotide-polymorphisms-of-rs1799937-located-in-wt1-gene-on-the-pathlogical-complete-response-to-neoadjuvant-chemotherapy-in-breast-cancer-patients
#2
M M Li, Y B Shao, H Liu, B Xu, B X He
Objective: To evaluate the association between single nucleotide polymorphisms (SNPs) of RS1799937 located in WT1 gene with complete response to neoadjuvant chemotherapy in breast cancer patients. Methods: 171 breast cancer patients with neoadjuvant chemotherapy were investigated to detect the RS1799937 polymorphism by sequenom method. The relationship between RS1799937 polymorphism and pathologic complete response (pCR) were analyzed by χ(2) test and Fisher's exact test analysis. Predictors of pCR were analyzed using multivariate logistic regression analysis...
November 29, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27910778/mirsnps-of-mir1274-and-mir3202-genes-that-target-mecp2-and-dnmt3b-are-associated-with-lung-cancer-risk-a-study-conducted-on-massarray-genotyping
#3
Cansu Ozbayer, Irfan Degirmenci, Derya Ustuner, Guntulu Ak, Faruk Saydam, Ertugrul Colak, Hasan Veysi Gunes, Muzaffer Metintas
Genetic variants of miRNAs that target DNMTs and MBDs involved in DNA methylation were scanned with current databases, and 35 miRSNPs in 22 miRNA genes were identified. The aim of the study was to determine the association between these variants of miRNA genes and lung cancer (LC). DNA samples were isolated from blood samples and genotyped using a Sequenom MassARRAY System. An association between the rs188912830 gene variant of miR3202 that targets the MeCP2 protein and LC was indicated in both subtypes. The presence of the C-allele in patients with LC and its subtypes was significantly lower, and the absence of the C-allele was determined to increase the risk of LC by 7,429-times compared to the presence (p=0,010)...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27907911/genetic-variants-in-the-znf208-gene-are-associated-with-esophageal-cancer-in-a-chinese-han-population
#4
Huijie Wang, Jianzhong Yu, Yanling Guo, Zhengxing Zhang, Guoqi Liu, Jingjie Li, Xiyang Zhang, Tianbo Jin, Zhaoxia Wang
Previous studies showed an association between the ZNF208 gene and gastric cancer. In this study, we investigated the association between single nucleotide polymorphisms (SNPs) in ZNF208 and the risk of esophageal cancer in a Chinese Han population. We conducted a case-control study that included 386 cases and 495 controls. Five SNPs were selected from previous genome-wide association studies and genotyped using the Sequenom MassARRAY platform. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals after adjustment for age and gender...
November 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27905470/a-previously-unreported-impact-of-a-pla2g7-gene-polymorphism-on-the-plasma-levels-of-lipoprotein-associated-phospholipase-a2-activity-and-mass
#5
Yue Qi, Dong Zhao, Zhangrong Jia, Wei Wang, Miao Wang, Jiayi Sun, Jun Liu, Yan Li, Wuxiang Xie, Jing Liu
Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA2, among 1258 participants from the Chinese Multi-provincial Cohort Study-Beijing Project. The Sequenom MassARRAY system, Taqman assay and direct sequencing were adopted. For the first time, the rs13218408 polymorphism was found to be significantly associated with reduced Lp-PLA2 levels...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27901213/the-rs11191580-variant-of-the-nt5c2-gene-is-associated-with-schizophrenia-and-symptom-severity-in-a-south-chinese-han-population-evidence-from-gwas
#6
Zhen Li, Juan Jiang, Jianxiong Long, Weijun Ling, Guifeng Huang, Xiaojing Guo, Li Su
Objective: Recent genome-wide association studies have identified a significant relationship between the NT5C2 variant rs11191580 and schizophrenia (SCZ) in European populations. This study aimed to validate the association of rs11191580 polymorphism with SCZ risk in a South Chinese Han population. The relationship of this polymorphism with the severity of SCZ clinical symptoms was also explored. Methods: A case-control study was performed in 462 patients with SCZ and 598 healthy controls...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27894080/genetic-variants-in-the-acylphosphatase-2-gene-and-the-risk-of-breast-cancer-in-a-han-chinese-population
#7
Fuli Zhang, Yan Zhang, Zhiping Deng, Pengcheng Xu, Xiyang Zhang, Tianbo Jin, Qiufang Liu
We performed a case-control study to investigate the associations between seven single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. There were 183 BC cases and 195 healthy controls included in the study. The SNPs were genotyped using the Sequenom MassARRAY platform. Logistic regression (adjusted for age group, body mass index [BMI], and menopause status), was used to evaluate the associations between the various genotypes and BC risk...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27893421/phactr1-and-slc22a3-gene-polymorphisms-are-associated-with-reduced-coronary-artery-disease-risk-in-the-male-chinese-han-population
#8
Qingbin Zhao, Huiyi Wei, Dandan Liu, Baolan Shi, Lei Li, Mengdan Yan, Xiyang Zhang, Fengjiao Wang, Yongri Ouyang
Previous studies showed that PHACTR1 and SLC22A3 are involved in coronary vascular development and are key determinants of cardiovascular disease risk. We conducted a case-control study to examine the effect of SLC22A3 and PHACTR1 single nucleotide polymorphisms (SNPs) on CAD risk among 376 male CAD patients and 388 male healthy controls from China. Eleven SLC22A3 and PHACTR1 SNPs were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27882721/survival-of-patients-with-metastatic-leiomyosarcoma-the-md-anderson-clinical-center-for-targeted-therapy-experience
#9
Zhijie Wang, Naiyi Shi, Aung Naing, Filip Janku, Vivek Subbiah, Dejka M Araujo, Shreyaskumar R Patel, Joseph A Ludwig, Lois M Ramondetta, Charles F Levenback, Pedro T Ramirez, Sarina A Piha-Paul, David Hong, Daniel D Karp, Apostolia M Tsimberidou, Funda Meric-Bernstam, Siqing Fu
Advanced stage leiomyosarcoma (LMS) is incurable with current systemic antitumor therapies. Therefore, there is clinical interest in exploring novel therapeutic regimens to treat LMS. We reviewed the medical records of 75 consecutive patients with histologically confirmed metastatic LMS, who had been referred to the Clinical Center for Targeted Therapy at MD Anderson Cancer Center. To lay the foundation for potential phase I trials for the treatment of advanced LMS, we analyzed tumor response and survival outcome data...
November 23, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27859227/il-1b-rs16944-polymorphism-is-related-to-septic-shock-and-death
#10
Maria Angeles Jiménez-Sousa, Luz M Medrano, Pilar Liu, Raquel Almansa, Amanda Fernández-Rodríguez, Esther Gomez-Sanchez, Lucía Rico, María Heredia-Rodriguez, Estefanía Gómez-Pesquera, Eduardo Tamayo, Salvador Resino
BACKGROUND: IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyze whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. METHODS: We performed a case-control study on 467 patients who underwent major cardiac or abdominal surgery. Out of them, 205 patients developed septic shock (Cases, SS-group) and 262 patients developed SIRS (Controls, SIRS-group)...
November 15, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27855134/effects-of-ugt1a6-and-gabra1-on-standardized-valproic-acid-plasma-concentrations-and-treatment-effect-in-children-with-epilepsy-in-china
#11
Weixing Feng, Shenghui Mei, Leting Zhu, Yazhen Yu, Weili Yang, Baoqin Gao, Xiaojuan Wu, Zhigang Zhao, Fang Fang
BACKGROUND: Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures. However, interindividual variations in plasma concentrations and treatment effects of patients with epilepsy treated with VPA are observed. This study aimed to evaluate the effects of various genetic variations on normalized plasma concentration of VPA (NCVPA) and the treatment response in Chinese children with epilepsy administered with VPA...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27844180/association-of-genetic-polymorphisms-in-mif-with-breast-cancer-risk-in-chinese-women
#12
Shuai Lin, Meng Wang, Xinghan Liu, Wenge Zhu, Yan Guo, Zhiming Dai, Pengtao Yang, Tian Tian, Cong Dai, Yi Zheng, Chunyan Hu, Linyan Wei, Zhijun Dai
Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of three common MIF gene variants (rs755622, rs1803976, rs11548059) with BC susceptibility in Chinese women. Total 560 breast cancer patients and 583 age- and sex-matched healthy individuals were recruited from Northwest China, and the DNA was genotyped by Sequenom MassARRAY...
November 14, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27831922/the-association-between-single-nucleotide-polymorphisms-of-the-apelin-gene-and-diabetes-mellitus-in-a-chinese-population
#13
Hui Zheng, Xiaofang Fan, Xuesong Li, Yu Zhang, Yujuan Fan, Ning Zhang, Yuping Song, Fengdong Ren, Chunfang Shen, Jiayi Shen, Jialin Yang
BACKGROUND: The objective of the study was to analyze the association of apelin gene (APLN) single nucleotide polymorphisms (SNPs) and type 2 diabetes mellitus (T2DM). METHODS: A total of 1966 subjects were enrolled in this study, including 168 cases (first batch), 330 cases (second batch), and 1468 nondiabetic controls. The SNPs in the HapMap-HCB of APLN were detected using Sequenom MassARRAY SNP technology and included rs2281068, rs3115757, rs2235309, and rs2235310...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27817778/-association-between-interleukin-1%C3%AE-c-3953t-and-genetic-susceptibility-to-spontaneous-preterm-birth-a-case-control-study
#14
Xiao Yang, Wei Peng, Li-Na Zhu, Xiao-Ai Zhang, Yan Wang
OBJECTIVE: To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB). METHODS: In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T. RESULTS: Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27809980/application-of-a-new-pcr-rflp-panel-suggests-a-restricted-population-structure-for-eimeria-tenella-in-uk-and-irish-chickens
#15
Elaine Pegg, Kate Doyle, Emily L Clark, Isa D Jatau, Fiona M Tomley, Damer P Blake
Eimeria species cause coccidiosis, most notably in chickens where the global cost exceeds US$3 billion every year. Understanding variation in Eimeria population structure and genetic diversity contributes valuable information that can be used to minimise the impact of drug resistance and develop new, cost-effective anticoccidial vaccines. Little knowledge is currently available on the epidemiology of Eimeria species and strains in different regions, or under different chicken production systems. Recently, 244 Eimeria tenella isolates collected from countries in Africa and Asia were genotyped using a Sequenom single nucleotide polymorphism (SNP) tool, revealing significant variation in haplotype diversity and population structure, with a marked North/South regional divide...
October 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27806314/tlr1-polymorphism-rs4833095-as-a-risk-factor-for-iga-nephropathy-in-a-chinese-han-population-a-case-control-study
#16
Jie Gao, Linting Wei, Jiali Wei, Ganglian Yao, Li Wang, Meng Wang, Xinghan Liu, Cong Dai, Tianbo Jin, Zhijun Dai, Rongguo Fu
Toll-like receptors (TLRs) are a family of transmembrane receptors, and play a vital role in recognizing invading pathogens and activating innate immunity. Previous studies indicated that TLR1 single nucleotide polymorphisms (SNPs) might be associated with the risk of IgA nephropathy (IgAN). This study aims to investigate the relationship between TLR1 SNPs (rs4833095 and rs5743557) and IgAN in a Chinese Han population. This case-control study included 351 patients with IgAN and 310 healthy controls. Two SNPs (rs4833095 and rs5743557) of TLR1 were genotyped by Sequenom MassARRAY...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27798902/genomic-characterisation-and-response-to-trastuzumab-and-paclitaxel-in-advanced-or-recurrent-her2-positive-endometrial-carcinoma
#17
Martin Koskas, Jeroen Depreeuw, Stijn Moens, Daniela Annibali, Tine Cuppens, Philippe Moerman, Diether Lambrechts, Frederic Amant
BACKGROUND/AIM: Human epidermal growth factor receptor 2 (HER2) positivity is associated with a worse prognosis in endometrial cancer (EC). Trastuzumab as a single agent did not demonstrate activity in such cases but there are no reports on its combined use with taxanes. We report the outcome in patients treated simultaneously with trastuzumab and paclitaxel for advanced or recurrent HER2-positive endometrial carcinoma and compared it to their microsatellite instability (MSI) status and PIK3CA mutational profiles...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27778160/new-evidence-for-involvement-of-esr1-gene-in-susceptibility-to-chinese-migraine
#18
Xingkai An, Jie Fang, Qing Lin, Congxia Lu, Qilin Ma, Hongli Qu
Migraine is a common and disabling nervous system disease with a significant genetic predisposition. The sex hormones play an important role in the pathogenesis of migraine. However, the conclusions of the previous genetic relation studies are conflicting. The aim of this study is to determine whether variants in genes involved in estrogen receptor and estrogen hormone metabolism are related to Chinese migraine. By employing a case-control approach, 8 SNPs in the ESR1, ESR2, and CYP19A1 genes are studied in a cohort of 494 migraine cases and 533 controls...
October 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27775096/genetic-analysis-of-innate-immunity-in-behcet-s-disease-identifies-an-association-with-il-37-and-il-18rap
#19
Handan Tan, Bolin Deng, Hongsong Yu, Yi Yang, Lin Ding, Qi Zhang, Jieying Qin, Aize Kijlstra, Rui Chen, Peizeng Yang
Interleukin-1 (IL-1) and the IL-1 receptor (IL-1R) family play an important role in the pathogenesis of inflammatory diseases. This study aimed to investigate the association between single nucleotide polymorphisms (SNP) of IL-1 and IL-1R family genes with Vogt-Koyanagi-Harada (VKH) and Behcet's disease (BD) in Han Chinese. The case-control study was divided into two stages and included 419 VKH cases, 1063 BD cases and 1872 healthy controls. The MassARRAY platform (Sequenom), iPLEX Gold Assay and TaqMan SNP assays were used to score genotypes of 24 SNPs...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27771229/comparative-study-on-driver-mutations-in-primary-and-metastatic-melanomas-at-a-single-japanese-institute-a-clue-for-intra-and-inter-tumor-heterogeneity
#20
Tatsuya Kaji, Osamu Yamasaki, Minoru Takata, Masaki Otsuka, Toshihisa Hamada, Shin Morizane, Kenji Asagoe, Hiroyuki Yanai, Yoji Hirai, Hiroshi Umemura, Keiji Iwatsuki
BACKGROUND: Searching for driver mutations in melanoma is critical to understanding melanoma genesis, progression and response to therapy. OBJECTIVES: We aimed to investigate the frequency and pattern of driver mutations in Japanese primary and metastatic melanomas including cases of unknown primary origin, in relation to their clinicopathologic manifestations. METHODS: Seventy-seven samples from 60 patients with melanoma were screened for 70 driver mutations of 20 oncogenes by Sequenom MelaCarta MassARRAY, and the results for primary and metastatic melanomas were compared...
October 13, 2016: Journal of Dermatological Science
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