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Luis Gerardo Natera Cisneros, Juan Sarasquete Reiriz
INTRODUCTION: Surgical indication for acromioclavicular joint (ACJ) injuries still represents a reason for shoulder and trauma debate. In high-grade injuries, surgery is advocated because some of the non-operatively managed patients may have persistent shoulder pain that could make them unable to return to their previous activity. It has been shown that many of the patients with high-grade ACJ injuries that are managed non-operatively involve the development of scapular dyskinesis, situation that may result in loss of strength and weakness...
October 12, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Christopher J Martin, Sean B McAdams, Haidar Abdul-Muhsin, Victoria M Lim, Rafael Nunez-Nateras, Mark D Tyson, Mitchell R Humphreys
PURPOSE: Questions still remain regarding the durability and longevity of flexible ureteroscopes (URS). The objective of this manuscript is to estimate potential economic benefits of the single use flexible digital URS compared to our recent experience with reusable flexible digital URS using cost benefit analysis. MATERIALS AND METHODS: Ureteroscopic procedures were prospectively recorded over a 12-month period (February 2014 - February 2015). All flexible ureteroscopies were performed using the Karl Storz Flex-XC™ digital ureteroscopes...
September 27, 2016: Journal of Urology
D Natera-de Benito, J Domínguez-Carral, N Muelas, A Nascimento, C Ortez, T Jaijo, R Arteaga, J Colomer, J J Vilchez
Congenital myasthenic syndromes (CMS) are a heterogeneous group of genetic disorders. Mutations in CHRNE are one of the most common cause of them and the ɛ1267delG frameshifting mutation is described to be present on at least one allele of 60% of patients with CHRNE mutations. We present a comprehensive description of the heterogeneous clinical features of the CMS caused by the homozygous 1267delG mutation in the AChR Ɛ subunit in nine members of two large Gipsy kindreds. Our observations indicate that founder Roma mutation 1267delG leads to a phenotype further characterized by ophthalmoplegia, bilateral ptosis, and good response to pyridostigmine and 3,4-DAP; but also by facial weakness, bulbar symptoms, neck muscle weakness, and proximal limb weakness that sometimes entails the loss of ambulation...
August 15, 2016: Neuromuscular Disorders: NMD
J Rodriguez Miralles, L Natera Cisneros, A Escolà, J C Fallone, M Cots, X Espiga
INTRODUCTION: Two types of ganglion cysts at the elbow have been described depending on their anatomic location. Type A ganglion cyst is located proximal to the arcade of Frohse, and type B distal to it. Compressive neuropathies of the radial nerve at the level of the radial tunnel may lead to two different clinical entities with different clinical manifestations. These different conditions depend on which branch is involved. Although compression of the deep motor branch due to a ganglion cyst has been previously described, affection of the superficial sensory branch is considered much rarer...
October 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Luis Natera Cisneros, Juan Sarasquete Reiriz
Surgical management of acute unstable acromioclavicular joint injuries should be focused on realigning the torn ends of the ligaments to allow for healing potential. The most widely utilized treatment methods incorporate the use of metal hardware, which can alter the biomechanics of the acromioclavicular joint. This leads to a second surgical procedure for hardware removal once the ligaments have healed. Patients with unstable acromioclavicular joint injuries managed with arthroscopy-assisted procedures have shown good and excellent clinical outcomes, without the need for a second operation...
August 19, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
C Alfaro-Iznaola, D Natera-de Benito, R Rodriguez-Diaz, M A Taboas-Pereira, M Cuadrado-Martin, M M Ballesteros-Garcia
INTRODUCTION: Cluster headache is a rare cause of primary headache in children. We report four cases with a mean age of onset of 8.6, ranged from 2 to 13 years. CASE REPORTS: Three males and one female with onset at 2, 7, 13, and 12 years-old, respectively, were included. The symptoms of all patients fulfill the criteria for the diagnosis of cluster headache according to the International Society of Headache. CONCLUSIONS: Despite being rare during childhood, cluster headache should be part of the differential diagnosis of headache in childhood...
July 16, 2016: Revista de Neurologia
Lucrecia García-Martínez, Irene Gracia-Ahulfinger, Isabel Machuca, Sara Cantisán, Soraya De La Fuente, Clara Natera, Elena Pérez-Nadales, Elisa Vidal, Antonio Rivero, Fernando Rodríguez-Lopez, José Ramón Del Prado, Julián Torre-Cisneros
BACKGROUND: There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance. OBJECTIVES: To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance. METHODS: A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid...
September 2016: Journal of Antimicrobial Chemotherapy
Giuseppe Vasile-Simone, Remedios Castro, Ramón Natera, Francesca Masino, Carmelo G Barroso, Enrique Durán-Guerrero
BACKGROUND: Stir bar sorptive extraction (SBSE) has been employed for the analysis of aroma compounds directly from Spanish and Italian grape extracts. The extraction conditions have been optimised using a statistical approach, obtaining results that improve the current state of the art. RESULTS: The proposed analytical conditions were: sample volume 40 mL, extraction time 80 min, 25% (w/v) of NaCl, and stirring speed 750 rpm using 20 mm × 0.5 mm stir bars...
May 25, 2016: Journal of the Science of Food and Agriculture
Esther Moya, Manuel Ribas, Luis Natera, Carlomagno Cardenas, Vittorio Bellotti, Emanuele Astarita
BACKGROUND: Many labral tears are nonrepairable. For these cases, labral reconstruction procedures may be considered in order to restore the joint fluid seal and prolong hip longevity. AIMS: The aim of this study was to describe the clinical and functional outcomes of a series of cases with nonrepairable labral tears that underwent labral reconstruction with tendon allografts. The hypothesis was that labral reconstruction would provide good clinical outcomes. METHOD: A cohort of 20 patients with nonrepairable labral tears, which underwent to labral grafting mainly by means of arthroscopic assisted anterior mini-open approach, were included in this study...
May 14, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Belén Gutiérrez-Gutiérrez, Salvador Pérez-Galera, Elena Salamanca, Marina de Cueto, Esther Calbo, Benito Almirante, Pierluigi Viale, Antonio Oliver, Vicente Pintado, Oriol Gasch, Luis Martínez-Martínez, Johann Pitout, Murat Akova, Carmen Peña, José Molina, Alicia Hernández, Mario Venditti, Nuria Prim, Julia Origüen, German Bou, Evelina Tacconelli, Mario Tumbarello, Axel Hamprecht, Helen Giamarellou, Manel Almela, Federico Pérez, Mitchell J Schwaber, Joaquín Bermejo, Warren Lowman, Po-Ren Hsueh, Marta Mora-Rillo, Clara Natera, Maria Souli, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Alvaro Pascual, Jesús Rodríguez-Baño
The spread of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) is leading to increased carbapenem consumption. Alternatives to carbapenems need to be investigated. We investigated whether β-lactam/β-lactamase inhibitor (BLBLI) combinations are as effective as carbapenems in the treatment of bloodstream infections (BSI) due to ESBL-E. A multinational, retrospective cohort study was performed. Patients with monomicrobial BSI due to ESBL-E were studied; specific criteria were applied for inclusion of patients in the empirical-therapy (ET) cohort (ETC; 365 patients), targeted-therapy (TT) cohort (TTC; 601 patients), and global cohort (GC; 627 patients)...
July 2016: Antimicrobial Agents and Chemotherapy
Luis Natera Cisneros, Mireia Gómez, Carlos Alvarez, Angélica Millán, Julio De Caso, Laura Soria
BACKGROUND: Tibial platfond fractures are usually associated with massive swelling of the foot and ankle, as well as with open wounds. This swelling may cause significant decrease of the blood flow, so the state of the soft tissue is determinant for the surgical indication and the type of implant. This retrospective study compares the union times in cases of tibial plafond fractures managed with a hybrid external fixation as a definitive procedure versus those managed with a two stage strategy with final plate fixation...
March 2016: Indian Journal of Orthopaedics
L Natera-Cisneros, H Santiago-Boccolini, J Sarasquete-Reiriz
The purpose of this paper is to assess the results obtained with the arthroscopy-assisted surgical technique for the treatment of chronic acromioclavicular joint instability (CACJI), based on non-rigid coracoclavicular (CC) fixation and anatomical CC reconstruction with a tendinous allograft. Patients with CACJI who underwent surgery between 2008 and 2012 were included in the study. Clinical assessments included SF36, VAS and DASH, applied at the preoperative visit (POV) and at the last follow-up visit (LFUV)...
May 2015: Acta Ortopédica Mexicana
Marcela Tiburcio Sainz, Ma Guadalupe Rosete-Mohedano, Guillermina Natera Rey, Nora Angélica Martínez Vélez, Silvia Carreño García, Daniel Pérez Cisneros
The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), developed by the World Health Organization (WHO), has been used successfully in many countries, but there are few studies of its validity and reliability for the Mexican population. The objective of this study was to determine the psychometric properties of the self-administered ASSIST test in university students in Mexico. This was an ex post facto non-experimental study with 1,176 undergraduate students, the majority women (70.1%) aged 18-23 years (89...
2016: Adicciones
L Natera, J Bruguera, E Atoun, O Levy
OBJECTIVE: To assess the surgical parameters and the clinical and radiological outcomes of revisions of resurfacing shoulder arthroplasty to non-cemented short-stem reverse total shoulder arthroplasty. MATERIAL AND METHODS: A total of 23 revisions from resurfacing shoulder arthroplasty to reverse total shoulder arthroplasty were performed. The mean age was 70.3±11.95 years. The patients included 82.6% (19/23) revised for cuff failure; 13.04% (3/23) cuff failure and aseptic loosening, and 4...
May 2016: Revista Española de Cirugía Ortopédica y Traumatología
A Vidal Esteban, D Natera-de Benito, D Martínez Sánchez, A Reche Sainz, M R Rodríguez Díaz, C M Alfaro Iznaola, M T de Santos Moreno
UNLABELLED: Harlequin syndrome (HS) is a rare autonomic disorder due to a hemifacial cutaneous sympathetic denervation. It is characterized by unilateral diminished sweating and flushing of the face even though after heat or prolonged exercise. It is typically acquired. Congenital cases only represent a 6% of all individuals with HS. All congenital HS cases reported so far showed a concomitant Horner syndrome, probably due to a stellate ganglion involvement. HS represents an uncommon autonomic disorder due to a hemifacial cutaneous sympathetic denervation...
May 2016: European Journal of Paediatric Neurology: EJPN
Luis Natera Cisneros, Juan Sarasquete Reiriz, Marina Besalduch, Alexandru Petrica, Ana Escolà, Joaquim Rodriguez, Jan Carlo Fallone
We describe the technical aspects of an arthroscopy-assisted procedure indicated for the management of acute unstable acromioclavicular joint injuries, consisting of a synthetic augmentation of both the coracoclavicular and acromioclavicular ligaments, that anatomically reproduces the coracoclavicular biomechanics and offers fixation that keeps the torn ends of the ligaments facing one another, thus allowing healing of the native structures without the need for a second surgical procedure for metal hardware removal...
December 2015: Arthroscopy Techniques
Luis Natera Cisneros, Juan Sarasquete Reiriz
Surgical treatment is usually indicated for the management of Neer type IIB fractures of the distal third of the clavicle. These unstable injuries have shown a rate of nonunion that oscillates around 30% to 45% when managed conservatively, and surgical strategies often require a second operation for implant removal. We describe an arthroscopic-assisted technique for the treatment of Neer type IIB unstable distal-third clavicle fractures that overcomes the issues related to open surgery, metal hardware, and implant irritation...
December 2015: Arthroscopy Techniques
Luis Gerardo Natera Cisneros, Ehud Atoun, Ruben Abraham, Oren Tsvieli, Juan Bruguera, Ofer Levy
BACKGROUND: The management of a failed shoulder arthroplasty represents a complex and difficult problem for the treating surgeon, with potential difficulties and complications that are related to the need to remove a well-fixed stem. The aim of this study is to compare the intraoperative complications, postoperative complications, and outcome of revisions from stemmed arthroplasties (STAs) with those from surface replacement arthroplasties (SRAs). METHODS: From 2005 to 2012, 40 consecutive revision shoulder arthroplasties were performed at our institute: 17 from STAs and 23 from SRAs...
May 2016: Journal of Shoulder and Elbow Surgery
Michelle H Le, April M Weissmiller, Louise Monte, Po Han Lin, Tia C Hexom, Orlangie Natera, Chengbiao Wu, Robert A Rissman
Stress exposure or increased levels of corticotropin-releasing factor (CRF) induce hippocampal tau phosphorylation (tau-P) in rodent models, a process that is dependent on the type-1 CRF receptor (CRFR1). Although these preclinical studies on stress-induced tau-P provide mechanistic insight for epidemiological work that identifies stress as a risk factor for Alzheimer's disease (AD), the actual impact of stress-induced tau-P on neuronal function remains unclear. To determine the functional consequences of stress-induced tau-P, we developed a novel mouse neuronal cell culture system to explore the impact of acute (0...
2016: PloS One
D Natera-de Benito, M Bestué, J J Vilchez, T Evangelista, A Töpf, A García-Ribes, M J Trujillo-Tiebas, M García-Hoyos, C Ortez, A Camacho, E Jiménez, M Dusl, A Abicht, H Lochmüller, J Colomer, A Nascimento
Rapsyn (RAPSN) mutations are a common cause of postsynaptic congenital myasthenic syndromes. We present a comprehensive description of the clinical and molecular findings of ten patients with CMS due to mutations in RAPSN, mostly with a long-term follow-up. Two patients were homozygous and eight were heterozygous for the common p.Asn88Lys mutation. In three of the heterozygous patients we have identified three novel mutations (c.869T > C; p.Leu290Pro, c.1185delG; p.Thr396Profs*12, and c.358delC; p.Gln120Serfs*8)...
February 2016: Neuromuscular Disorders: NMD
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