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https://www.readbyqxmd.com/read/29333394/evaluation-of-anti-wrinkle-effects-of-duoligo-composed-of-lactulose-and-galactooligosaccharides
#1
Eun Young Jung, Jung Il Kwon, Yang Hee Hong, Hyung Joo Suh
Currently, alternatives to prebiotics for skin treatment are receiving much interest. However, little is known about the efficacy of topically applied prebiotics in skin anti-aging. This study was conducted to observe the anti-aging effects of DuOligo, which is composed of lactulose and galactooligosaccharides (GOS). We investigated wrinkle-related parameters by quantitative and qualitative skin evaluation in healthy women who consumed DuOligo for 8 weeks. The double-blind, randomized, and placebo-controlled study included subjects who were divided into two groups (Placebo: dextrin 4...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29297141/lactulose-a-simple-sugar-in-a-complex-encephalopathy
#2
Eelco F M Wijdicks
Hepatic encephalopathy is a common encephalopathy and one of the very few that are treatable. Lactulose has remained a standard pharmaceutical intervention and is listed as one of the World Health Organization's Essential Medicines. The discovery of lactulose, the acid dialysis proof of concept, and the role of Bircher are not well known. This historical vignette reviews the gradual understanding of the complex liver-brain connection, the effective treatment of hepatic stupor with lactulose, and the immediate relevance of lactulose to the practice of consultative neurocritical care...
January 2, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29248204/intestinal-permeability-and-m%C3%A3-ni%C3%A3-re-s-disease
#3
F Di Berardino, D Zanetti, E Ciusani, C Caccia, V Leoni, U De Grazia, E Filipponi, L Elli
PURPOSE: Ménière disease (MD) is a multifactorial chronic disabling condition characterized by episodic vertigo, ear fullness, and hearing loss. MD patients often complain of aspecific gastrointestinal symptoms associated with autonomic dysregulation, frequently outweighed by the otological manifestations. Dietary modifications have been reported to improve the typical MD symptoms in some cases. Our purpose was to test the urinary levels of lactulose and mannitol (double sugar test) and the fecal calprotectin, both markers of altered intestinal permeability, in subjects with definite MD in an active and inactive stage...
December 5, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29234915/the-impact-of-exertional-heat-stress-on-gastrointestinal-integrity-gastrointestinal-symptoms-systemic-endotoxin-and-cytokine-profile
#4
Rhiannon M J Snipe, Anthony Khoo, Cecilia M Kitic, Peter R Gibson, Ricardo J S Costa
PURPOSE: The study aimed to determine the effects of exertional-heat stress on gastrointestinal integrity, symptoms, systemic endotoxin and inflammatory responses; and assess the relationship between changes in body temperature and gastrointestinal perturbations. METHODS: Ten endurance runners completed 2 h running at 60% [Formula: see text]O2max in hot (HOT: 35 °C) and temperate (TEMP: 22 °C)-ambient conditions. Rectal temperature (T re) and gastrointestinal symptoms were recorded every 10 min during exercise...
December 12, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29233137/rational-modification-of-substrate-binding-site-by-structure-based-engineering-of-a-cellobiose-2-epimerase-in-caldicellulosiruptor-saccharolyticus
#5
Ah-Reum Park, Jin-Sook Kim, Seung-Won Jang, Young-Gyun Park, Bong-Seong Koo, Hyeon-Cheol Lee
BACKGROUND: Lactulose, a synthetic disaccharide, has received increasing interest due to its role as a prebiotic, specifically proliferating Bifidobacilli and Lactobacilli and enhancing absorption of calcium and magnesium. The use of cellobiose 2-epimerase (CE) is considered an interesting alternative for industrial production of lactulose. CE reversibly converts D-glucose residues into D-mannose residues at the reducing end of unmodified β-1,4-linked oligosaccharides, including β-1,4-mannobiose, cellobiose, and lactose...
December 12, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29231544/-acupoint-embedding-for-female-functional-constipation-a-randomized-controlled-trial
#6
Lifang Chen, Xiaofei Jin, Xu Jiang, Chao Wang, Yichun Shi, Lingyu Wang
OBJECTIVE: To compare the effects between acupoint embedding and oral medication for female functional constipation. METHODS: Fifty-six female patients were randomized into an embedding group and a medication group (1:1).There were 22 cases in the embedding group and 26 cases in the medication group with total 8 patients dropped out. The main embedding acupoints were Zhongwan (CV 12), bilateral Tianshu (ST 25) and Guanyuan (CV 4), combined with Xiawan (CV 10), Huaroumen (ST 24), Wailing (ST 26), Zhigou (TE 6) and Shangjuxu (ST 37)...
July 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231472/-acupuncture-with-smoothing-liver-and-regulating-qi-for-post-stroke-slow-transit-constipation-and-its-gastrointestinal-hormone-level
#7
Yanhong Gao, Jianmei Li, Mao Su, Yanling Li
OBJECTIVE: To compare the efficacy between acupuncture with smoothing liver and regulating qi and lactulose for post-stroke slow transit constipation(STC) and to explore the mechanism. METHODS: Sixty patients were randomized into an acupuncture group and a medication group,30 cases in each one. Based on the comprehensive stroke unit care,acupuncture with smoothing liver and regulating qi was used at Danzhong(CV 17),Qihai(CV 6),Tianshu(ST 25),Neiguan(PC 6),Gongsun(SP 4) and Taichong(LR 3) in the acupuncture group,once a day...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230485/-importance-of-functional-diagnostics-in-gastroenterology
#8
REVIEW
M Hollenbach, A Hoffmeister, J Rosendahl, J Mössner
In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test can be carried out when there is a suspicion of abnormal intestinal bacterial colonization and using lactulose for measuring small intestinal transit time...
December 11, 2017: Der Internist
https://www.readbyqxmd.com/read/29230345/new-trends-for-the-evaluation-of-heat-treatments-of-milk
#9
REVIEW
Mena Ritota, Maria Gabriella Di Costanzo, Maria Mattera, Pamela Manzi
Milk is generally very rich in nutrients and this may lead it to be an ideal growth environment for many microorganisms, including pathogens, so effective measurements aiming to ensure total microbiological safety of milk and minimize the risk to human health are needed. Milk heat treatments are the most common practices carried out to inhibit the microbial growth; therefore it is necessary to have analytical procedures that are more and more up-to-date and capable of detecting the effectiveness of the heat treatments...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29228433/the-relationship-between-small-intestinal-bacterial-overgrowth-and-irritable-bowel-syndrome
#10
X-W Ding, Y-X Liu, X-C Fang, K Liu, Y-Y Wei, M-H Shan
OBJECTIVE: To explore the relationship between small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS). PATIENTS AND METHODS: Fifty IBS patients in the hospital from January 2015 to December 2015 were assigned to the treatment group, and 50 healthy persons were assigned to the control group. Lactulose hydrogen and methane breath test were performed to measure the percentage of SIBO and oro-cecal transit time (OCTT) in treatment group and control group...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29225942/correction-improving-the-detection-of-environmental-enteric-dysfunction-a-lactulose-rhamnose-assay-of-intestinal-permeability-in-children-aged-under-5-years-exposed-to-poor-sanitation-and-hygiene
#11
https://www.readbyqxmd.com/read/29201772/managing-encephalopathy-in-the-outpatient-setting
#12
REVIEW
Tarana Gupta, Sahaj Rathi, Radha K Dhiman
In cirrhosis of liver, hepatic encephalopathy (HE) has an important impact on health-related quality of life. It is important to define whether HE is episodic, recurrent, or persistent; types A, B, or C; overt HE or covert HE; and spontaneous or precipitated. The overt HE is clinically evident and needs hospitalization. Nonabsorbable disaccharides, rifaximin, and probiotics are proven to be useful in the treatment of overt HE. Covert HE includes both minimal HE and grade I HE. It is not apparent on routine clinical examination...
January 2017: Euroasian journal of hepato-gastroenterology
https://www.readbyqxmd.com/read/29188472/small-intestinal-bacterial-overgrowth-should-screening-be-included-in-the-pre-fecal-microbiota-transplantation-evaluation
#13
Jessica R Allegretti, Zain Kassam, Walter W Chan
BACKGROUND: Fecal microbiota transplantation (FMT) is safe and effective for recurrent Clostridium difficile infection (rCDI) and often involves terminal ileal (TI) stool infusion. Patients report gastrointestinal (GI) symptoms post-FMT despite rCDI resolution. Small intestinal bacterial overgrowth (SIBO) screening is not routinely performed pre-FMT. The effect of donor/recipient SIBO status on FMT outcomes and post-FMT GI symptoms is unclear. We aim to evaluate the value of pre-FMT SIBO screening on post-FMT outcomes and symptoms...
November 29, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29179682/faecal-bacterial-microbiota-in-patients-with-cirrhosis-and-the-effect-of-lactulose-administration
#14
Aditya Narayan Sarangi, Amit Goel, Ankur Singh, Avani Sasi, Rakesh Aggarwal
BACKGROUND: Gut microbiota may be altered in patients with cirrhosis, and may further change after administration of lactulose. We studied the composition of gut microbiota in patients with cirrhosis and assessed the effect on it of lactulose administration. METHODS: Stool specimens were collected from 35 patients with cirrhosis (male 26; median [range] age: 42 [29-65] years) and 18 healthy controls (male 14; 44.5 [24-67] years); 21 patients provided another specimen after lactulose administration for 55 [42-77] days...
November 28, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29171503/-prevention-and-treatment-of-hepatic-encephalopathy
#15
Yu P Sivolap
Hepatic encephalopathy is a common neuropsychiatric complication of serious liver diseases and serves as a marker for worsening of their course and increasing the risk of death. The principal pathogenesis factors of hepatic encephalopathy is the excessive formation of ammonia and its accumulation by astrocytes. A key role in the prevention and treatment of hepatic encephalopathy is played by drugs that prevent hyperammonemia and promote the removal of ammonia from the body, namely lactulose, rifaximin and L-ornithine-L-aspartate...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29166952/effects-of-dietary-live-yeast-supplementation-on-growth-performance-diarrhoea-severity-intestinal-permeability-and-immunological-parameters-of-weaned-piglets-challenged-with-enterotoxigenic-escherichia-coli-k88
#16
Lianqiang Che, Qin Xu, Cheng Wu, Yuheng Luo, Xiaobo Huang, Bo Zhang, Eric Auclair, Tadele Kiros, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, De Wu
This study aimed to investigate the effects of dietary live yeast (LY) supplementation on growth, intestinal permeability and immunological parameters of piglets challenged with enterotoxigenic Escherichia coli K88 (ETEC). Piglets weaned at 21 d were allocated into three treatments with six pens and six piglets per pen, receiving the control diet (CON), diets supplemented with antibiotics plus zinc oxide (ANT-ZnO) and LY (Saccharomyces cerevisiae strain CNCM I-4407), respectively, for a period of 2 weeks. On day 8, thirty-six piglets were selected as control without ETEC (CON), CON-ETEC, ANT-ZnO-ETEC and LY-ETEC groups challenged with ETEC until day 10 for sample collections...
November 23, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29161572/new-%C3%AE-galactosidase-producers-with-potential-for-prebiotic-synthesis
#17
Sara C Silvério, Eugénia A Macedo, José A Teixeira, Lígia R Rodrigues
β-Galactosidases (EC 3.2.1.23) are interesting enzymes with potential application in the pharmaceutical and food industry. In this work, a screening study was carried out to identify new fungal sources of β-galactosidase. A total of 50 fungi were evaluated using a chromogenic test performed in agar plates. The most promising microorganisms were validated as effective β-galactosidase producers under submerged fermentation conditions. The crude β-galactosidases were characterized regarding their optimal pH (3...
November 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29158542/metabolic-profiling-of-umbilical-cord-blood-in-macrosomia
#18
H Sun, Y Wang, C Wang, X Xu, Y Wang, H Yan, X Yang
BACKGROUND/OBJECTIVE: The term macrosomia is used to describe neonates with a birth weight of 4000 g or more. Macrosomia is a potential risk factor for obesity and metabolic syndromes in postnatal and adult life, yet little is known about its associations with metabolic difference in the early-age. We performed metabolic profiling of umbilical cord blood to discover differential metabolites of macrosomia. METHODS: We conducted a case-control study of full-term singletons with normal maternal glucose tolerance [50 cases (macrosomia, birth weight ⩾4000 g); 50 controls (normal weight, birth weight 2500-3999 g)]...
November 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29152432/acute-changes-in-mentation-in-a-patient-with-hepatic-cirrhosis-treated-with-high-doses-of-dexamethasone
#19
Luis Dabul, Andrew Droney, Juan Oms, Marcos A Sanchez-Gonzalez
Despite the anti-inflammatory benefits of steroids in the management of multiple medical conditions, they are associated with undesired metabolic and psychiatric side effects. We present a case of a 57-year-old Hispanic man with hepatic cirrhosis due to hepatitis C and no past medical history of psychiatric illnesses who became delirious after treatment with high doses of intravenous Dexamethasone. The patient presented to Larkin Community Hospital, USA with complaints of lower back pain requiring treatment with steroids for severe lumbar central canal stenosis...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29123461/intestinal-absorption-and-factors-influencing-bioavailability-of-magnesium-an-update
#20
REVIEW
Jan Philipp Schuchardt, Andreas Hahn
Background: Information on the bioavailability of the essential mineral Mg2+ is sparse. Objective/Method: Evaluation of the present knowledge on factors influencing the bioavailability and intestinal absorption of Mg2+. Results: Mg2+ is absorbed via a paracellular passive and a transcellular active pathway that involves TRPM6/7 channel proteins. The bioavailability of Mg2+ varies within a broad range, depending on the dose, the food matrix, and enhancing and inhibiting factors...
November 2017: Current Nutrition and Food Science
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