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https://www.readbyqxmd.com/read/29660417/rdoc-based-categorization-of-amygdala-functions-and-its-implications-in-autism
#1
REVIEW
Thomas Hennessey, Elissar Andari, Donald G Rainnie
Confusion endures as to the exact role of the amygdala in relation to autism. To help resolve this we turned to the NIMH's Research Domain Criteria (RDoC) which provides a classification schema that identifies different categories of behaviors that can turn pathologic in mental health disorders, e.g. autism. While RDoC incorporates all the known neurobiological substrates for each domain, this review will focus primarily on the amygdala. We first consider the amygdala from an anatomical, historical, and developmental perspective...
April 13, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29594136/crossing-the-worm-brain-barrier-by-using-caenorhabditis-elegans-to-explore-fundamentals-of-human-psychiatric-illness
#2
REVIEW
Donard S Dwyer
Endophenotypes and Research Domain Criteria (RDoC) represent recent efforts to deconvolute psychiatric illnesses into fundamental symptom clusters or biological markers more closely linked to genetic influences. By taking this one step farther, these biomarkers can be reduced to protophenotypes - endophenotypes conserved during evolution - with counterparts in lower organisms including Caenorhabditis elegans and Drosophila . Striking conservation in C. elegans of genes that increase the risk for mental illness bolsters the relevance of this model system for psychiatric research...
February 2018: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29578748/negative-emotionality-across-diagnostic-models-rdoc-dsm-5-section-iii-and-ffm
#3
Whitney L Gore, Thomas A Widiger
The research domain criteria (RDoC) were established in an effort to explore underlying dimensions that cut across many existing disorders and to provide an alternative to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). One purpose of the present study was to suggest a potential alignment of RDoC negative valence with 2 other dimensional models of negative emotionality: five-factor model (FFM) neuroticism and the DSM-5 Section III negative affectivity. A second purpose of the study, though, was to compare their coverage of negative emotionality, more specifically with respect to affective instability...
March 2018: Personality Disorders
https://www.readbyqxmd.com/read/29527592/data-science-in-the-research-domain-criteria-era-relevance-of-machine-learning-to-the-study-of-stress-pathology-recovery-and-resilience
#4
Isaac R Galatzer-Levy, Kelly Ruggles, Zhe Chen
Diverse environmental and biological systems interact to influence individual differences in response to environmental stress. Understanding the nature of these complex relationships can enhance the development of methods to: (1) identify risk, (2) classify individuals as healthy or ill, (3) understand mechanisms of change, and (4) develop effective treatments. The Research Domain Criteria (RDoC) initiative provides a theoretical framework to understand health and illness as the product of multiple inter-related systems but does not provide a framework to characterize or statistically evaluate such complex relationships...
January 2018: Chronic Stress
https://www.readbyqxmd.com/read/29526524/implications-of-the-research-domain-criteria-project-for-childhood-anxiety-and-its-disorders
#5
REVIEW
Eli R Lebowitz, Dylan G Gee, Daniel S Pine, Wendy K Silverman
Anxiety disorders are among the most prevalent psychiatric disorders in youth; however, progress in treatment for childhood anxiety has stalled over the past decade. The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) project represents a shift toward a dimensional and interdisciplinary approach to psychiatric disorders; this shift can reframe developmental psychopathology for childhood anxiety and facilitate novel advances in its classification and treatment. Here we highlight constructs in the Systems for Social Processes and the Negative Valence System domains of RDoC, as they relate to childhood anxiety disorders...
January 31, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29524018/advancing-the-study-of-sluggish-cognitive-tempo-via-dsm-rdoc-and-hierarchical-models-of-psychopathology
#6
REVIEW
Stephen P Becker, Erik G Willcutt
Sluggish cognitive tempo (SCT) is separable from attention-deficit/hyperactivity disorder (ADHD) and other psychopathologies, and growing evidence demonstrates SCT to be associated with impairment in both children and adults. However, it remains unclear how SCT should optimally be conceptualized. In this article, we argue that multiple models of psychopathology should be leveraged to make substantive advances to our understanding of SCT. Both categorical and dimensional approaches should be used, including the Diagnostic and Statistical Manual of Mental Disorders (DSM) nosology, the Research Domain Criteria (RDoC) initiative, and hierarchical models of psychopathology...
March 10, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29426573/intolerance-of-uncertainty-in-youth-with-obsessive-compulsive-disorder-and-generalized-anxiety-disorder-a-transdiagnostic-construct-with-implications-for-phenomenology-and-treatment
#7
REVIEW
Carrie B Gillett, Emily L Bilek, Gregory L Hanna, Kate D Fitzgerald
Obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) are early-onset disorders with significant overlapping phenomenology, especially in young patients who, due to developmental stage, may have difficulty recognizing obsessions and worries as unrealistic or excessive. Shared phenomenology and high rates of comorbidity between OCD and GAD raise the possibility of common underlying processes, and recent work has focused on intolerance of uncertainty (IU) as a reasonable candidate. With an emphasis on the youth literature, we review the phenomenological overlap between OCD and GAD, how symptoms may relate to IU, and how IU may be measured...
February 2, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29410313/motor-dysfunction-as-research-domain-in-the-period-preceding-manifest-schizophrenia-a-systematic-review
#8
REVIEW
Dusan Hirjak, Andreas Meyer-Lindenberg, Katharina M Kubera, Philipp A Thomann, Robert C Wolf
Schizophrenia is a severe behavioral syndrome of neurodevelopmental nature marked by primary or genuine motor abnormalities (GMA), which refer to spontaneous and medication-independent motor phenomena. Since motor dysfunction thus might be a consequence of events occurring during early childhood and adolescence, GMA can be detected in the period preceding manifest schizophrenia. However, the question whether motor system dysfunction might be a promising motor intermediate phenotype for schizophrenia remains unanswered...
February 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29407725/heart-rate-reactivity-to-trauma-related-imagery-as-a-measure-of-ptsd-symptom-severity-examining-a-new-cohort-of-veterans
#9
Paula L Castro-Chapman, Scott P Orr, John Berg, Suzanne L Pineles, Jessica Yanson, Kristen Salomon
For over three decades, there has been considerable research documenting increased physiological reactivity to trauma-related stimuli as a characteristic feature of posttraumatic stress disorder (PTSD). The present study explored the potential for physiological assessment to aid in defining and validating screening criteria for the presence of significant PTSD-related symptoms in a sample of OEF/OIF/OND Veterans seeking care in a VA post-deployment health clinic. Heart rate reactivity scores during the imagining phase of the script-driven imagery paradigm were compared across groups of individuals with and without probable PTSD diagnoses, as defined by PCL-IV cutoff scores ranging from 40 to 60...
January 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29405754/developing-dimensional-pandiagnostic-inhibitory-control-constructs-with-self-report-and-neuropsychological-data
#10
Natania A Crane, Alvaro Vergés, Masoud Kamali, Runa Bhaumik, Kelly A Ryan, David F Marshall, Erika F H Saunders, Michelle T Kassel, Anne L Weldon, Melvin G McInnis, Scott A Langenecker
Trait markers, or intermediate phenotypes linking different units of analysis (self-report, performance) from the Research Domain Criteria (RDoC) matrix across populations is a necessary step in identifying at-risk individuals. In the current study, 150 healthy controls (HC) and 456 individuals with bipolar disorder (BD) Type I or II, NOS (not otherwise specified) or Schizoaffective BD completed self-report neuropsychological tests of inhibitory control (IC) and executive functioning. Bifactor analyses were used to examine the factor structure of these measures and to evaluate for invariance across groups...
February 1, 2018: Assessment
https://www.readbyqxmd.com/read/29391395/genome-wide-analysis-of-self-reported-risk-taking-behaviour-and-cross-disorder-genetic-correlations-in-the-uk-biobank-cohort
#11
Rona J Strawbridge, Joey Ward, Breda Cullen, Elizabeth M Tunbridge, Sarah Hartz, Laura Bierut, Amy Horton, Mark E S Bailey, Nicholas Graham, Amy Ferguson, Donald M Lyall, Daniel Mackay, Laura M Pidgeon, Jonathan Cavanagh, Jill P Pell, Michael O'Donovan, Valentina Escott-Price, Paul J Harrison, Daniel J Smith
Risk-taking behaviour is a key component of several psychiatric disorders and could influence lifestyle choices such as smoking, alcohol use, and diet. As a phenotype, risk-taking behaviour therefore fits within a Research Domain Criteria (RDoC) approach, whereby identifying genetic determinants of this trait has the potential to improve our understanding across different psychiatric disorders. Here we report a genome-wide association study in 116,255 UK Biobank participants who responded yes/no to the question "Would you consider yourself a risk taker?" Risk takers (compared with controls) were more likely to be men, smokers, and have a history of psychiatric disorder...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29374138/a-shared-vision-for-machine-learning-in-neuroscience
#12
Mai-Anh T Vu, Tulay Adali, Demba Ba, Gyorgy Buzsaki, David Carlson, Katherine Heller, Conor Liston, Cynthia Rudin, Vikaas Sohal, Alik S Widge, Helen S Mayberg, Guillermo Sapiro, Kafui Dzirasa
With ever-increasing advancements in technology, neuroscientists are able to collect data in greater volumes and with finer resolution. The bottleneck in understanding how the brain works is consequently shifting away from the amount and type of data we can collect and toward what we actually do with the data. There has been a growing interest in leveraging this vast volume of data across levels of analysis, measurement techniques, and experimental paradigms to gain more insight into brain function. Such efforts are visible at an international scale, with the emergence of big data neuroscience initiatives such as the BRAIN initiative(Bargmann et al...
January 26, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29348040/negative-valence-in-autism-spectrum-disorder-the-relationship-between-amygdala-activity-selective-attention-and-co-occurring-anxiety
#13
John D Herrington, Brenna B Maddox, Alana J McVey, Martin E Franklin, Benjamin E Yerys, Judith S Miller, Robert T Schultz
BACKGROUND: A critical agenda of the National Institutes of Health Research Domain Criteria (RDoC) initiative is establishing whether domains within the RDoC matrix are truly transdiagnostic. Rates of anxiety disorders are elevated in autism spectrum disorder (ASD), but it is unclear whether the same mechanisms contribute to anxiety in individuals with and without ASD. As changes in selective attention are a hallmark of anxiety disorders in non-ASD samples, the identification of these changes in ASD would support the transdiagnostic nature of anxiety...
September 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29321077/social-anxiety-disorder-looking-back-and-moving-forward
#14
Matthew P Hyett, Peter M McEvoy
Fifty years have passed since social anxiety disorder (SAD) was first differentiated from other phobias. In the years since research has largely aligned with the zeitgeist of categorical classificatory frameworks, and has spanned identifying causes, maintenance factors and innovative interventions. Despite significant advances in the field, the capacity to conceptualise SAD as an independent entity is limited given the heterogeneity and dimensionality of diagnostic criteria, high rates of comorbidity, and non-specificity of aetiological mechanisms, maintaining factors and approaches to treatment...
January 11, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29303015/tests-of-the-attachment-and-developmental-dynamic-systems-theory-of-crime-addstoc-toward-a-differential-rdoc-diagnostic-and-treatment-approach
#15
Marc A Lindberg, Dana Zeid
The Attachment and Developmental Dynamic Systems Theory of Crime was tested on 206 male inmates. They completed measures tapping attachments, clinical issues, adverse childhood events, peer crime, and crime addictions. A significant path model was found, going from insecure parental attachments to adverse childhood events, and then on to the behavioral crime addiction and criminal peers scales. Peer crime was also predicted by insecure parent attachments and the crime addiction scale. Finally, the crime addiction, peer crime, and insecure parental attachment scales predicted frequencies of criminal behavior...
January 1, 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29249958/unlocking-neurocognitive-substrates-of-late-life-affective-symptoms-using-the-research-domain-criteria-worry-is-an-essential-dimension
#16
Sherry A Beaudreau, Nathan C Hantke, Nehjla Mashal, Christine E Gould, Victor W Henderson, Ruth O'Hara
While investigations have sought to identify the distinct and shared contributions of anxiety and depression to neurocognitive processes in late life, less is known regarding the further contribution of worry, a unique and critical dimension of affective dysregulation. Capturing the full range of symptoms, as inspired by the NIH Research Domain Criteria (RDoC), may provide finer-grained information on inter-relationships among worry, anxiety and depression on neurocognitive processing in later life. The objective of this study was to determine if the dimensional trait of worry intensifies known negative associations of dimensional measures of anxiety and depressive symptoms with neurocognitive processes, specifically cognitive control and memory processes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29211974/three-approaches-to-understanding-and-classifying-mental-disorder-icd-11-dsm-5-and-the-national-institute-of-mental-health-s-research-domain-criteria-rdoc
#17
Lee Anna Clark, Bruce Cuthbert, Roberto Lewis-Fernández, William E Narrow, Geoffrey M Reed
The diagnosis of mental disorder initially appears relatively straightforward: Patients present with symptoms or visible signs of illness; health professionals make diagnoses based primarily on these symptoms and signs; and they prescribe medication, psychotherapy, or both, accordingly. However, despite a dramatic expansion of knowledge about mental disorders during the past half century, understanding of their components and processes remains rudimentary. We provide histories and descriptions of three systems with different purposes relevant to understanding and classifying mental disorder...
September 2017: Psychological Science in the Public Interest: a Journal of the American Psychological Society
https://www.readbyqxmd.com/read/29172598/biological-underpinnings-of-an-internalizing-pathway-to-alcohol-cigarette-and-marijuana-use
#18
Elisa M Trucco, Sandra Villafuerte, Andrea Hussong, Margit Burmeister, Robert A Zucker
There is a limited understanding as to how specific genes impact addiction risk. Applying a developmental framework and research domain criteria (RDoC) to identify etiological pathways from genetic markers to addiction may have utility. Prior research has largely focused on externalizing pathways to substance use. Although internalizing mechanisms have received less attention, there is strong support that addiction is a longer term consequence of using substances to cope with internalizing as well as externalizing problems...
January 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29152902/the-genetics-of-human-personality
#19
REVIEW
S Sanchez-Roige, J C Gray, J MacKillop, C-H Chen, A A Palmer
Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder...
March 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29107398/the-stress-reward-mentalizing-model-of-depression-an-integrative-developmental-cascade-approach-to-child-and-adolescent-depressive-disorder-based-on-the-research-domain-criteria-rdoc-approach
#20
REVIEW
Patrick Luyten, Peter Fonagy
The Research Domain Criteria (RDoC) propose a much-needed change in approach to the study of vulnerability factors implicated in mental disorders, shifting away from a categorical, disease-oriented model to a dimensional approach that focuses on underlying systems implicated in psychopathology. In this paper we illustrate this approach with a focus on the emergence of depression in childhood and adolescence. Based on evolutionary biological and developmental psychopathology considerations, we present an integrative developmental cascade model of depression that essentially suggests that depression emerges out of a three-pronged series of interacting impairments in the domains of stress regulation, reward, and mentalizing...
October 9, 2017: Clinical Psychology Review
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