keyword
MENU ▼
Read by QxMD icon Read
search

RDoC

keyword
https://www.readbyqxmd.com/read/29426573/intolerance-of-uncertainty-in-youth-with-obsessive-compulsive-disorder-and-generalized-anxiety-disorder-a-transdiagnostic-construct-with-implications-for-phenomenology-and-treatment
#1
REVIEW
Carrie B Gillett, Emily L Bilek, Gregory L Hanna, Kate D Fitzgerald
Obsessive-compulsive disorder (OCD) and generalized anxiety disorder (GAD) are early-onset disorders with significant overlapping phenomenology, especially in young patients who, due to developmental stage, may have difficulty recognizing obsessions and worries as unrealistic or excessive. Shared phenomenology and high rates of comorbidity between OCD and GAD raise the possibility of common underlying processes, and recent work has focused on intolerance of uncertainty (IU) as a reasonable candidate. With an emphasis on the youth literature, we review the phenomenological overlap between OCD and GAD, how symptoms may relate to IU, and how IU may be measured...
February 2, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29410313/motor-dysfunction-as-research-domain-in-the-period-preceding-manifest-schizophrenia-a-systematic-review
#2
REVIEW
Dusan Hirjak, Andreas Meyer-Lindenberg, Katharina M Kubera, Philipp A Thomann, Robert C Wolf
Schizophrenia is a severe behavioral syndrome of neurodevelopmental nature marked by primary or genuine motor abnormalities (GMA), which refer to spontaneous and medication-independent motor phenomena. Since motor dysfunction thus might be a consequence of events occurring during early childhood and adolescence, GMA can be detected in the period preceding manifest schizophrenia. However, the question whether motor system dysfunction might be a promising motor intermediate phenotype for schizophrenia remains unanswered...
February 2, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29407725/heart-rate-reactivity-to-trauma-related-imagery-as-a-measure-of-ptsd-symptom-severity-examining-a-new-cohort-of-veterans
#3
Paula L Castro-Chapman, Scott P Orr, John Berg, Suzanne L Pineles, Jessica Yanson, Kristen Salomon
For over three decades, there has been considerable research documenting increased physiological reactivity to trauma-related stimuli as a characteristic feature of posttraumatic stress disorder (PTSD). The present study explored the potential for physiological assessment to aid in defining and validating screening criteria for the presence of significant PTSD-related symptoms in a sample of OEF/OIF/OND Veterans seeking care in a VA post-deployment health clinic. Heart rate reactivity scores during the imagining phase of the script-driven imagery paradigm were compared across groups of individuals with and without probable PTSD diagnoses, as defined by PCL-IV cutoff scores ranging from 40 to 60...
January 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29405754/developing-dimensional-pandiagnostic-inhibitory-control-constructs-with-self-report-and-neuropsychological-data
#4
Natania A Crane, Alvaro Vergés, Masoud Kamali, Runa Bhaumik, Kelly A Ryan, David F Marshall, Erika F H Saunders, Michelle T Kassel, Anne L Weldon, Melvin G McInnis, Scott A Langenecker
Trait markers, or intermediate phenotypes linking different units of analysis (self-report, performance) from the Research Domain Criteria (RDoC) matrix across populations is a necessary step in identifying at-risk individuals. In the current study, 150 healthy controls (HC) and 456 individuals with bipolar disorder (BD) Type I or II, NOS (not otherwise specified) or Schizoaffective BD completed self-report neuropsychological tests of inhibitory control (IC) and executive functioning. Bifactor analyses were used to examine the factor structure of these measures and to evaluate for invariance across groups...
February 1, 2018: Assessment
https://www.readbyqxmd.com/read/29391395/genome-wide-analysis-of-self-reported-risk-taking-behaviour-and-cross-disorder-genetic-correlations-in-the-uk-biobank-cohort
#5
Rona J Strawbridge, Joey Ward, Breda Cullen, Elizabeth M Tunbridge, Sarah Hartz, Laura Bierut, Amy Horton, Mark E S Bailey, Nicholas Graham, Amy Ferguson, Donald M Lyall, Daniel Mackay, Laura M Pidgeon, Jonathan Cavanagh, Jill P Pell, Michael O'Donovan, Valentina Escott-Price, Paul J Harrison, Daniel J Smith
Risk-taking behaviour is a key component of several psychiatric disorders and could influence lifestyle choices such as smoking, alcohol use, and diet. As a phenotype, risk-taking behaviour therefore fits within a Research Domain Criteria (RDoC) approach, whereby identifying genetic determinants of this trait has the potential to improve our understanding across different psychiatric disorders. Here we report a genome-wide association study in 116,255 UK Biobank participants who responded yes/no to the question "Would you consider yourself a risk taker?" Risk takers (compared with controls) were more likely to be men, smokers, and have a history of psychiatric disorder...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29374138/a-shared-vision-for-machine-learning-in-neuroscience
#6
Mai-Anh T Vu, Tulay Adali, Demba Ba, Gyorgy Buzsaki, David Carlson, Katherine Heller, Conor Liston, Cynthia Rudin, Vikaas Sohal, Alik S Widge, Helen S Mayberg, Guillermo Sapiro, Kafui Dzirasa
With ever-increasing advancements in technology, neuroscientists are able to collect data in greater volumes and with finer resolution. The bottleneck in understanding how the brain works is consequently shifting away from the amount and type of data we can collect and toward what we actually do with the data. There has been a growing interest in leveraging this vast volume of data across levels of analysis, measurement techniques, and experimental paradigms to gain more insight into brain function. Such efforts are visible at an international scale, with the emergence of big data neuroscience initiatives such as the BRAIN initiative(Bargmann et al...
January 26, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29348040/negative-valence-in-autism-spectrum-disorder-the-relationship-between-amygdala-activity-selective-attention-and-co-occurring-anxiety
#7
John D Herrington, Brenna B Maddox, Alana J McVey, Martin E Franklin, Benjamin E Yerys, Judith S Miller, Robert T Schultz
BACKGROUND: A critical agenda of the National Institutes of Health Research Domain Criteria (RDoC) initiative is establishing whether domains within the RDoC matrix are truly transdiagnostic. Rates of anxiety disorders are elevated in autism spectrum disorder (ASD), but it is unclear whether the same mechanisms contribute to anxiety in individuals with and without ASD. As changes in selective attention are a hallmark of anxiety disorders in non-ASD samples, the identification of these changes in ASD would support the transdiagnostic nature of anxiety...
September 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29321077/social-anxiety-disorder-looking-back-and-moving-forward
#8
Matthew P Hyett, Peter M McEvoy
Fifty years have passed since social anxiety disorder (SAD) was first differentiated from other phobias. In the years since research has largely aligned with the zeitgeist of categorical classificatory frameworks, and has spanned identifying causes, maintenance factors and innovative interventions. Despite significant advances in the field, the capacity to conceptualise SAD as an independent entity is limited given the heterogeneity and dimensionality of diagnostic criteria, high rates of comorbidity, and non-specificity of aetiological mechanisms, maintaining factors and approaches to treatment...
January 11, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29303015/tests-of-the-attachment-and-developmental-dynamic-systems-theory-of-crime-addstoc-toward-a-differential-rdoc-diagnostic-and-treatment-approach
#9
Marc A Lindberg, Dana Zeid
The Attachment and Developmental Dynamic Systems Theory of Crime was tested on 206 male inmates. They completed measures tapping attachments, clinical issues, adverse childhood events, peer crime, and crime addictions. A significant path model was found, going from insecure parental attachments to adverse childhood events, and then on to the behavioral crime addiction and criminal peers scales. Peer crime was also predicted by insecure parent attachments and the crime addiction scale. Finally, the crime addiction, peer crime, and insecure parental attachment scales predicted frequencies of criminal behavior...
January 1, 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29249958/unlocking-neurocognitive-substrates-of-late-life-affective-symptoms-using-the-research-domain-criteria-worry-is-an-essential-dimension
#10
Sherry A Beaudreau, Nathan C Hantke, Nehjla Mashal, Christine E Gould, Victor W Henderson, Ruth O'Hara
While investigations have sought to identify the distinct and shared contributions of anxiety and depression to neurocognitive processes in late life, less is known regarding the further contribution of worry, a unique and critical dimension of affective dysregulation. Capturing the full range of symptoms, as inspired by the NIH Research Domain Criteria (RDoC), may provide finer-grained information on inter-relationships among worry, anxiety and depression on neurocognitive processing in later life. The objective of this study was to determine if the dimensional trait of worry intensifies known negative associations of dimensional measures of anxiety and depressive symptoms with neurocognitive processes, specifically cognitive control and memory processes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29211974/three-approaches-to-understanding-and-classifying-mental-disorder-icd-11-dsm-5-and-the-national-institute-of-mental-health-s-research-domain-criteria-rdoc
#11
Lee Anna Clark, Bruce Cuthbert, Roberto Lewis-Fernández, William E Narrow, Geoffrey M Reed
The diagnosis of mental disorder initially appears relatively straightforward: Patients present with symptoms or visible signs of illness; health professionals make diagnoses based primarily on these symptoms and signs; and they prescribe medication, psychotherapy, or both, accordingly. However, despite a dramatic expansion of knowledge about mental disorders during the past half century, understanding of their components and processes remains rudimentary. We provide histories and descriptions of three systems with different purposes relevant to understanding and classifying mental disorder...
September 2017: Psychological Science in the Public Interest: a Journal of the American Psychological Society
https://www.readbyqxmd.com/read/29172598/biological-underpinnings-of-an-internalizing-pathway-to-alcohol-cigarette-and-marijuana-use
#12
Elisa M Trucco, Sandra Villafuerte, Andrea Hussong, Margit Burmeister, Robert A Zucker
There is a limited understanding as to how specific genes impact addiction risk. Applying a developmental framework and research domain criteria (RDoC) to identify etiological pathways from genetic markers to addiction may have utility. Prior research has largely focused on externalizing pathways to substance use. Although internalizing mechanisms have received less attention, there is strong support that addiction is a longer term consequence of using substances to cope with internalizing as well as externalizing problems...
November 27, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29152902/the-genetics-of-human-personality
#13
REVIEW
Sandra Sanchez-Roige, Joshua C Gray, James K MacKillop, Chi-Hua Chen, Abraham A Palmer
Personality traits are the relatively enduring patterns of thoughts, feelings, and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have demonstrated that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria (RDoC) characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder (MDD)...
November 20, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29107398/the-stress-reward-mentalizing-model-of-depression-an-integrative-developmental-cascade-approach-to-child-and-adolescent-depressive-disorder-based-on-the-research-domain-criteria-rdoc-approach
#14
REVIEW
Patrick Luyten, Peter Fonagy
The Research Domain Criteria (RDoC) propose a much-needed change in approach to the study of vulnerability factors implicated in mental disorders, shifting away from a categorical, disease-oriented model to a dimensional approach that focuses on underlying systems implicated in psychopathology. In this paper we illustrate this approach with a focus on the emergence of depression in childhood and adolescence. Based on evolutionary biological and developmental psychopathology considerations, we present an integrative developmental cascade model of depression that essentially suggests that depression emerges out of a three-pronged series of interacting impairments in the domains of stress regulation, reward, and mentalizing...
October 9, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29083029/dimensional-assessment-of-schizotypal-psychotic-and-other-psychiatric-traits-in-children-and-their-parents-development-and-validation-of-the-childhood-oxford-liverpool-inventory-of-feelings-and-experiences-on-a-representative-us-sample
#15
David W Evans, Laina G Lusk, Mylissa M Slane, Andrew M Michael, Scott M Myers, Mirko Uljarević, Oliver Mason, Gordon Claridge, Thomas Frazier
BACKGROUND: Healthy functioning relies on a variety of perceptual, cognitive, emotional, and behavioral abilities that are distributed throughout the normal population. Variation in these traits define the wide range of neurodevelopmental (NDD) and neuropsychiatric (NPD) disorders. Here, we introduce a new measure for assessing these traits in typically developing children and children at risk for NDD and NPD from age 2 to 18 years. METHOD: The Childhood Oxford-Liverpool Inventory of Feelings and Experiences (CO-LIFE) was created as a dimensional, parent-report measure of schizotypal and psychotic traits in the general population...
October 30, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29064611/understanding-suicide-risk-within-the-research-domain-criteria-rdoc-framework-a-meta-analytic-review
#16
Catherine R Glenn, Evan M Kleiman, Christine B Cha, Charlene A Deming, Joseph C Franklin, Matthew K Nock
BACKGROUND: The field is in need of novel and transdiagnostic risk factors for suicide. The National Institute of Mental Health's Research Domain Criteria (RDoC) provides a framework that may help advance research on suicidal behavior. METHOD: We conducted a meta-analytic review of existing prospective risk and protective factors for suicidal thoughts and behaviors (ideation, attempts, and deaths) that fall within one of the five RDoC domains or relate to a prominent suicide theory...
October 24, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29055388/how-extreme-dieting-becomes-compulsive-a-novel-hypothesis-for-the-role-of-anxiety-in-the-development-and-maintenance-of-anorexia-nervosa
#17
E C Lloyd, I Frampton, B Verplanken, A M Haase
The US National Institute of Mental Health's Research Domain Criteria (NIMH RDoC) advocates the study of features common to psychiatric conditions. This transdiagnostic approach has recently been adopted into the study of anorexia nervosa (AN), an illness that can be considered compulsive in nature. This has led to the development of an account of AN that identifies key roles for the heightened reinforcement of starvation, leading to its excessive repetition, and goal-directed system dysfunction. Considering models of illness in other compulsive disorders, we extend the existing account to explain the emergence of reinforcement and goal-directed system abnormalities in AN, proposing that anxiety is central to both processes...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29054288/using-the-research-domain-criteria-rdoc-to-conceptualize-impulsivity-and-compulsivity-in-relation-to-addiction
#18
Samantha J Brooks, Christine Lochner, Steve Shoptaw, Dan J Stein
Nomenclature for mental disorder was updated in 2013 with the publication of the fifth edition of the Diagnostic and Statistical Manual (DSM-5). In DSM-5, substance use disorders are framed as more dimensional. First, the distinction between abuse and dependence is replaced by substance use. Second, the addictions section now covers both substances and behavioral addictions. This contemporary move toward dimensionality and transdiagnosis in the addictions and other disorders embrace accumulating cognitive-affective neurobiological evidence that is reflected in the United States' National Institutes of Health Research Domain Criteria (NIH RDoC)...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29042245/a-natural-language-processing-challenge-for-clinical-records-research-domains-criteria-rdoc-for-psychiatry
#19
EDITORIAL
Özlem Uzuner, Amber Stubbs, Michele Filannino
No abstract text is available yet for this article.
October 16, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28979198/schizophrenia-what-s-arc-got-to-do-with-it
#20
REVIEW
Francesca Managò, Francesco Papaleo
Human studies of schizophrenia are now reporting a previously unidentified genetic convergence on postsynaptic signaling complexes such as the activity-regulated cytoskeletal-associated (Arc) gene. However, because this evidence is still very recent, the neurobiological implication of Arc in schizophrenia is still scattered and unrecognized. Here, we first review current and developing findings connecting Arc in schizophrenia. We then highlight recent and previous findings from preclinical mouse models that elucidate how Arc genetic modifications might recapitulate schizophrenia-relevant behavioral phenotypes following the novel Research Domain Criteria (RDoC) framework...
2017: Frontiers in Behavioral Neuroscience
keyword
keyword
37488
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"