keyword
MENU ▼
Read by QxMD icon Read
search

RDoC

keyword
https://www.readbyqxmd.com/read/28316565/six-years-of-research-on-the-national-institute-of-mental-health-s-research-domain-criteria-rdoc-initiative-a-systematic-review
#1
REVIEW
Dean Carcone, Anthony C Ruocco
Six years have passed since the National Institute of Mental Health (NIMH) in the United States launched the Research Domain Criteria (RDoC) initiative. The RDoC introduces a framework for research on the biology of mental illness that integrates research findings across multiple levels of information. The framework outlines constructs that represent specific quantifiable dimensions of behavior (e.g., responses to acute threat, cognitive control) and corresponding units of analysis that can be used to study the constructs, beginning at the levels of genes, molecules, cells, circuits and physiology, and moving up to behaviors and self-reports...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28267146/new-dimensions-and-new-tools-to-realize-the-potential-of-rdoc-digital-phenotyping-via-smartphones-and-connected-devices
#2
J Torous, J-P Onnela, M Keshavan
Mobile and connected devices like smartphones and wearable sensors can facilitate the collection of novel naturalistic and longitudinal data relevant to psychiatry at both the personal and population level. The National Institute of Mental Health's Research Domain Criteria framework offers a useful roadmap to organize, guide and lead new digital phenotyping data towards research discoveries and clinical advances.
March 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28237133/reward-processing-and-mood-related-symptoms-an-rdoc-and-translational-neuroscience-perspective
#3
REVIEW
Robin Nusslock, Lauren B Alloy
BACKGROUND: Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) mechanisms that are unique to specific psychiatric symptoms, and that reflect markers of differential risk for these symptoms. With respect to these objectives, a brain-behavior dimension that has received considerable attention and that is directly relevant to the Positive Valence Systems domain of the RDoC initiative involves reward processing...
February 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28224734/anxiety-genetics-dispatches-from-the-frontier
#4
Jordan W Smoller
Anxiety disorders are the most common class of psychiatric disorders and incur an enormous burden in terms of economic costs, disability and personal suffering. Despite their public health importance and documented heritability, genetic research aimed at identifying the genetic contributions to these disorders has had limited success, particularly in comparison to recent advances in the genetics of other major psychiatric disorders. The major factor contributing to this lagging progress has been a dearth of well-powered genomic studies...
March 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28188401/-research-domain-criteria-rdoc-psychiatric-research-as-applied-cognitive-neuroscience
#5
H Walter
BACKGROUND: Just before the official launch of the DSM-5 in 2013, the Research Domain Criteria (RDoC) initiative of the National Institute of Mental Health was made public and is becoming increasingly more important in psychiatric research. OBJECTIVE: The aim of this paper is to clarify the conceptual approach of RDoC, to systematically discuss limitations, to present exemplary RDoC-based studies and to consider the relevance of the RDoC concepts for clinicians and scientists...
February 10, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28167616/towards-trans-diagnostic-mechanisms-in-psychiatry-neurobehavioral-profile-of-rats-with-a-loss-of-function-point-mutation-in-the-dopamine-transporter-gene
#6
Valentina Vengeliene, Anton Bespalov, Martin Roßmanith, Sandra Horschitz, Stefan Berger, Ana L Relo, Hamid R Noori, Peggy Schneider, Thomas Enkel, Dusan Bartsch, Miriam Schneider, Berthold Behl, Anita C Hansson, Patrick Schloss, Rainer Spanagel
The Research Domain Criteria (RDoC) matrix has been developed to reorient psychiatric research towards measurable behavioral dimensions and underlying mechanisms. Here we used a new genetic rat model with a loss of function point mutation in the dopamine transporter (DAT) gene (Slc6a3_N157K) to systematically study the RDoC matrix (www.nimh.nih.gov/research-priorities/rdoc/constructs/rdoc-matrix.shtml). First, we examined the impact of the Slc6a3_N157K mutation on monoaminergic signaling. We then performed behavioral tests representing each of the five RDoC domains - negative and positive valence systems, cognitive, social, and in arousal/regulatory systems...
February 6, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28165268/using-the-research-domain-criteria-framework-to-track-domains-of-change-in-comorbid-ptsd-and-sud
#7
Laura Zambrano-Vazquez, Hannah C Levy, Emily L Belleau, Emily R Dworkin, Katianne M Howard Sharp, Samantha L Pittenger, Julie A Schumacher, Scott F Coffey
OBJECTIVES: Comorbidity in diagnosis raises critical challenges for psychological assessment and treatment. The Research Domain Criteria (RDoC) Project, launched by the National Institutes of Mental Health, proposes domains of functioning as a way to conceptualize the overlap between comorbid conditions and inform treatment selection. However, further research is needed to understand common comorbidities (e.g., posttraumatic stress disorder [PTSD] and substance use disorder [SUD]) from an RDoC framework and how existing evidence-based treatments would be expected to promote change in the RDoC domains of functioning...
February 6, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28150390/gray-matter-relationships-to-diagnostic-and-transdiagnostic-features-of-drug-and-behavioral-addictions
#8
Sarah W Yip, Patrick D Worhunsky, Jiansong Xu, Kristen P Morie, R Todd Constable, Robert T Malison, Kathleen M Carroll, Marc N Potenza
Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combines categorical (diagnosis-based) and dimensional (transdiagnostic) approaches to identify neural structural alterations linked to addiction subtypes and trait impulsivity, respectively, across individuals with gambling disorder (n = 35), individuals with cocaine-use disorder (n = 37) and healthy comparison individuals (n = 37)...
February 1, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28131628/latent-variable-analysis-of-positive-and-negative-valence-processing-focused-on-symptom-and-behavioral-units-of-analysis-in-mood-and-anxiety-disorders
#9
Martin P Paulus, Murray B Stein, Michelle G Craske, Susan Bookheimer, Charles T Taylor, Alan N Simmons, Natasha Sidhu, Katherine S Young, Boyang Fan
BACKGROUND: Mood and anxiety disorders are highly heterogeneous and their underlying pathology is complex. The Research Domain Criteria (RDoC) approach seeks to establish dimensionally and neuroscience-based descriptions of psychopathology that may inform better classification and treatment approaches. The current investigation sought to determine the latent variables underlying positive and negative valence processing in terms of symptoms and behavioral units of analysis. METHOD: As part of an ongoing study, individuals with mood and anxiety problems were recruited largely from primary care clinics at UCLA (n=62) and UCSD (n=58)...
January 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28124571/the-dsm5-rdoc-debate-on-the-future-of-mental-health-research-implication-for-studies-on-human-stress-and-presentation-of-the-signature-bank
#10
S J Lupien, M Sasseville, N François, C E Giguère, J Boissonneault, P Plusquellec, R Godbout, L Xiong, S Potvin, E Kouassi, A Lesage
In 2008, the National Institute of Mental Health (NIMH) announced that in the next few decades, it will be essential to study the various biological, psychological and social "signatures" of mental disorders. Along with this new "signature" approach to mental health disorders, modifications of DSM were introduced. One major modification consisted of incorporating a dimensional approach to mental disorders, which involved analyzing, using a transnosological approach, various factors that are commonly observed across different types of mental disorders...
January 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28093239/application-of-technology-to-social-communication-impairment-in-childhood-and-adolescence
#11
REVIEW
Andrea Trubanova Wieckowski, Susan W White
Social communication impairment has been implicated in various mental health disorders. The primary aim of this review paper is to summarize the extant research on the development and application of technologies to address social communication deficits, conceptualized according to the four constructs outlined by the NIMH's Research Domain Criteria (RDoC), transdiagnostically in children and adolescents. An exhaustive and systematic search yielded 69 peer-reviewed articles meeting all inclusion criteria (i.e...
January 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28072415/functional-neuroimaging-effects-of-recently-discovered-genetic-risk-loci-for-schizophrenia-and-polygenic-risk-profile-in-five-rdoc-subdomains
#12
S Erk, S Mohnke, S Ripke, T A Lett, I M Veer, C Wackerhagen, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, M Mattheisen, T W Mühleisen, K Charlet, N Skarabis, F Kiefer, S Cichon, S H Witt, M M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter
Recently, 125 loci with genome-wide support for association with schizophrenia were identified. We investigated the impact of these variants and their accumulated genetic risk on brain activation in five neurocognitive domains of the Research Domain Criteria (working memory, reward processing, episodic memory, social cognition and emotion processing). In 578 healthy subjects we tested for association (i) of a polygenic risk profile score (RPS) including all single-nucleotide polymorphisms (SNPs) reaching genome-wide significance in the recent genome-wide association studies (GWAS) meta-analysis and (ii) of all independent genome-wide significant loci separately that showed sufficient distribution of all allelic groups in our sample (105 SNPs)...
January 10, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28067006/addressing-reverse-inference-in-psychiatric-neuroimaging-meta-analyses-of-task-related-brain-activation-in-common-mental-disorders
#13
Emma Sprooten, Alexander Rasgon, Morgan Goodman, Ariella Carlin, Evan Leibu, Won Hee Lee, Sophia Frangou
Functional magnetic resonance imaging (fMRI) studies in psychiatry use various tasks to identify case-control differences in the patterns of task-related brain activation. Differently activated regions are often ascribed disorder-specific functions in an attempt to link disease expression and brain function. We undertook a systematic meta-analysis of data from task-fMRI studies to examine the effect of diagnosis and study design on the spatial distribution and direction of case-control differences on brain activation...
April 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28010957/research-domain-criteria-rdoc-grows-up-strengthening-neurodevelopmental-investigation-within-the-rdoc-framework
#14
REVIEW
Vijay A Mittal, Lauren S Wakschlag
No abstract text is available yet for this article.
December 16, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28002661/potential-applications-of-the-national-institute-of-mental-health-s-research-domain-criteria-rdoc-to-clinical-psychiatric-practice-how-rdoc-might-be-used-in-assessment-diagnostic-processes-case-formulation-treatment-planning-and-clinical-notes
#15
Joel Yager, Robert E Feinstein
Offering a new framework for understanding and studying basic dimensions of normal and abnormal human functioning and mental disorders, the National Institute of Mental Health (NIMH) has initiated the Research Domain Criteria (RDoC) project in which a series of higher order domains, representing major systems of emotion, cognition, motivation, and social behavior, and their constituent operationally defined constructs serve as organizing templates for further research and inquiry, eg, to discover validated biomarkers and endophenotypes...
December 20, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27936452/exercise-is-an-effective-treatment-for-positive-valence-symptoms-in-major-depression
#16
Marisa Toups, Thomas Carmody, Tracy Greer, Chad Rethorst, Bruce Grannemann, Madhukar H Trivedi
INTRODUCTION: Measurement of symptoms domains and their response to treatment in relative isolation from diagnosed mental disorders has gained new urgency, as reflected by the National Institute of Mental Health's introduction of the Research Domain Criteria (RDoC). The Snaith Hamilton Pleasure Scale (SHAPS) and the Motivation and Energy Inventory (MEI) are two scales measuring positive valence symptoms. We evaluated the effect of exercise on positive valence symptoms of Major Depressive Disorder (MDD)...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27923496/neural-correlates-of-rdoc-reward-constructs-in-adolescents-with-diverse-psychiatric-symptoms-a-reward-flanker-task-pilot-study
#17
Kailyn A L Bradley, Julia A C Case, Rachel D Freed, Emily R Stern, Vilma Gabbay
BACKGROUND: There has been growing interest under the Research Domain Criteria initiative to investigate behavioral constructs and their underlying neural circuitry. Abnormalities in reward processes are salient across psychiatric conditions and may precede future psychopathology in youth. However, the neural circuitry underlying such deficits has not been well defined. Therefore, in this pilot, we studied youth with diverse psychiatric symptoms and examined the neural underpinnings of reward anticipation, attainment, and positive prediction error (PPE, unexpected reward gain)...
December 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27876165/application-of-research-domain-criteria-to-childhood-and-adolescent-impulsive-and-addictive-disorders-implications-for-treatment
#18
REVIEW
Sarah W Yip, Marc N Potenza
The Research Domain Criteria (RDoC) initiative provides a large-scale, dimensional framework for the integration of research findings across traditional diagnoses, with the long-term aim of improving existing psychiatric treatments. A neurodevelopmental perspective is essential to this endeavor. However, few papers synthesizing research findings across childhood and adolescent disorders exist. Here, we discuss how the RDoC framework may be applied to the study of childhood and adolescent impulsive and addictive disorders in order to improve neurodevelopmental understanding and to enhance treatment development...
November 9, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27863803/research-domain-criteria-and-the-study-of-trauma-in-children-implications-for-assessment-and-treatment-research
#19
REVIEW
Carla Smith Stover, Brooks Keeshin
By definition, the Diagnostic and Statistical Manual (DSM) diagnosis of posttraumatic stress disorder (PTSD) requires exposure to a traumatic event. Yet, the DSM diagnostic requirements for children and adolescents for PTSD may fail to capture traumatized youth with significant distress and functional impairment. Many important studies have utilized PTSD diagnosis as a mechanism for grouping individuals for comparative studies examining brain functioning, neuroendocrinology, genetics, attachment, and cognition; however, focusing only on those with the diagnosis of PTSD can miss the spectrum of symptoms and difficulties that impact children who experience trauma and subsequent impairment...
November 9, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27855961/moderators-of-age-effects-on-attention-bias-toward-threat-and-its-association-with-anxiety
#20
Nauder Namaky, Miranda L Beltzer, Alexandra J Werntz, Ann E Lambert, Derek M Isaacowitz, Bethany A Teachman
OBJECTIVE: The current study used a research domain criteria (RDoC) approach to assess age differences in multiple indicators of attention bias and its ties to anxiety, examining stimulus domain and cognitive control as moderators of older adults' oft-cited positivity effect (bias towards positive and away from negative stimuli, when compared to younger adults). METHOD: 38 Younger adults and 38 older adults were administered a battery of cognitive control and trait and state anxiety measures, and completed a dot-probe task to assess attention bias, during which reaction time and fixation duration (using eye-tracking) were recorded for negative and neutral social (a salient threat domain for younger adults) and physical (a salient threat domain for older adults) stimuli...
November 4, 2016: Journal of Affective Disorders
keyword
keyword
37488
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"