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https://www.readbyqxmd.com/read/29351662/the-versatile-tanycyte-a-hypothalamic-integrator-of-reproduction-and-energy-metabolism
#1
Vincent Prevot, Bénédicte Dehouck, Ariane Sharif, Philippe Ciofi, Paolo Giacobini, Jerome Clasadonte
The fertility and survival of an individual rely on the ability of the periphery to promptly, effectively and reproducibly communicate with brain neural networks that control reproduction, food intake and energy homeostasis. Tanycytes, a specialized glial cell type lining the wall of the third ventricle in the median eminence of the hypothalamus, appear to act as the linchpin of these processes by dynamically controlling the secretion of neuropeptides into the portal vasculature by hypothalamic neurons and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on the ability of these cells to adapt their morphology to the physiological state of the individual...
January 17, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29351361/pathways-of-nitric-oxide-metabolism-and-operation-of-phytoglobins-in-legume-nodules-missing-links-and-future-directions
#2
Antoine Berger, Renaud Brouquisse, Pradeep Kumar Pathak, Imène Hichri, Inderjit Singh, Sabhyata Bhatia, Alexandre Boscari, Abir U Igamberdiev, Kapuganti Jagadis Gupta
The interaction between legumes and rhizobia leads to the establishment of a beneficial symbiotic relationship. Recent advances in legume - rhizobium symbiosis revealed that various reactive oxygen and nitrogen species including nitric oxide (NO) play important roles during this process. Nodule development occurs with a transition from a normoxic environment during the establishment of symbiosis to a microoxic environment in functional nodules. Such oxygen dynamics are required for activation and repression of various NO production and scavenging pathways...
January 19, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29351284/magnetic-resonance-angiography-with-compressed-sensing-an-evaluation-of-moyamoya-disease
#3
Takayuki Yamamoto, Tomohisa Okada, Yasutaka Fushimi, Akira Yamamoto, Koji Fujimoto, Sachi Okuchi, Hikaru Fukutomi, Jun C Takahashi, Takeshi Funaki, Susumu Miyamoto, Aurélien F Stalder, Yutaka Natsuaki, Peter Speier, Kaori Togashi
Compressed sensing (CS) reconstructions of under-sampled measurements generate missing data based on assumptions of image sparsity. Non-contrast time-of-flight MR angiography (TOF-MRA) is a good candidate for CS based acceleration, as MRA images feature bright trees of sparse vessels over a well-suppressed anatomical background signal. A short scan time derived from CS is beneficial for patients of moyamoya disease (MMD) because of the frequency of MR scans. The purpose of this study was to investigate the reliability of TOF-MRA with CS in the evaluation of MMD...
2018: PloS One
https://www.readbyqxmd.com/read/29351117/associations-of-comorbid-anxiety-with-medication-adherence-and-psychiatric-symptomatology-in-a-population-of-nonadherent-bipolar-disorder-subjects
#4
Awais Aftab, Jennifer Levin, Michelle Aebi, Chetan Bhat, Martha Sajatovic
This analysis was conducted on baseline data from 178 nonadherent bipolar disorder subjects in a randomized controlled trial. Medication adherence was measured with Tablets Routine Questionnaire as percentage of days with missed doses. Inclusion criteria required at least 20% nonadherence. Medication adherence, symptomatology, and functioning in individuals with and without a comorbid anxiety disorder were compared. There were 78.9% of subjects who had at least one or more current anxiety disorder, with the most common being posttraumatic stress disorder, panic disorder, and generalized anxiety disorder...
January 19, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29350641/traumatic-fractures-in-adults-missed-diagnosis-on-plain-radiographs-in-the-emergency-department
#5
Antonio Pinto, Daniela Berritto, Anna Russo, Federica Riccitiello, Martina Caruso, Maria Paola Belfiore, Vito Roberto Papapietro, Marina Carotti, Fabio Pinto, Andrea Giovagnoni, Luigia Romano, Roberto Grassi
Radiography remains the imaging standard for fracture detection after trauma. The radiographic diagnosis of most fractures and dislocations poses little difficulty to radiologists: however, occasionally these injuries are quite subtle or even impossible to detect on radiographs. Missed diagnoses of fracture potentially have important consequences for patients, clinicians, and radiologists. Radiologists play a pivot role in the diagnostic assessment of the trauma patients: emergency radiologists who are more practiced at seeking out and discerning traumatic fractures can provide an invaluable service to their clinical colleagues by ensuring that patients do not endure delayed diagnoses...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350639/dynamic-mri-in-the-evaluation-of-the-spine-state-of-the-art
#6
Giulia Michelini, Antonella Corridore, Silvia Torlone, Federico Bruno, Claudia Marsecano, Raffaella Capasso, Ferdinando Caranci, Antonio Barile, Carlo Masciocchi, Alessandra Splendiani
INTRODUCTION: Degenerative disease of the spine is a generic term encompassing a wide range of different disease processes, which leads to spinal instability; traumatic/neoplastic events can accelerate this aging process. Therefore, the dynamic nature of the spine and its mobility across multiple segments is difficult to depict with any single imaging modality. METHODS: A review of PubMed databases for articles published about kMRI in patients with cervical and lumbar spinal desease was performed...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350505/bridging-the-digital-divide-mobile-access-to-personal-health-records-among-patients-with-diabetes
#7
Ilana Graetz, Jie Huang, Richard J Brand, John Hsu, Cyrus K Yamin, Mary E Reed
OBJECTIVES: Some patients lack regular computer access and experience a digital divide that causes them to miss internet-based health innovations. The diffusion of smartphones has increased internet access across the socioeconomic spectrum, and increasing the channels through which patients can access their personal health records (PHRs) could help bridge the divide in PHR use. We examined PHR use through a computer-based Web browser or mobile device. STUDY DESIGN: Cross-sectional historical cohort analysis...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29350373/pediatric-dural-venous-sinus-thrombosis-following-closed-head-injury-an-easily-overlooked-diagnosis-with-devastating-consequences
#8
Joe M Das, Rashmi Sapkota, Binjura Shrestha
Dural venous sinus thrombosis (DVST) is an uncommon finding after traumatic brain injury. The diagnosis can often be initially missed, particularly if not associated with an overlying fracture. Pediatric DVST following closed head injury and without an overlying fracture is very rare, with only 20 cases reported in the literature to date. Here we present the case of a 19-month-old boy who presented with a history of trivial fall and an episode of fever. On presentation, the pediatric Glasgow Coma Scale (pGCS) score was E3V4M6, and initial brain computed tomography (CT) was normal...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350331/motion-deficit-in-nodal-interphalangeal-joint-osteoarthritis-by-digital-goniometer-in-housewives
#9
L Ventura-Ríos, M Hayes-Salinas, D Ferrusquia-Toriz, R I Cariño-Escobar, E Cruz-Arenas, J Gutiérrez-Martínez, L González-Ramírez, C Hernández-Díaz
Range of motion (ROM) measured objectively in nodal hand osteoarthritis (NHOA) is missing. Evaluation of collateral ligaments by ultrasound (US) is unknown in NHOA also. To compare ROM in interphalangeal joints in housewives with nodal OA, with a control group by a digital system using angle to voltage (Multielgon). The second objective was to assess correlation between collateral radial and ulnar ligaments thickness and ROM. For this cross-sectional observational study, we assessed 60 hands with symptomatic NHOA and 30 hands of healthy housewives matched for age...
January 19, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29350321/sliding-to-predict-vision-based-beating-heart-motion-estimation-by-modeling-temporal-interactions
#10
Angelica I Aviles-Rivero, Samar M Alsaleh, Alicia Casals
PURPOSE: Technical advancements have been part of modern medical solutions as they promote better surgical alternatives that serve to the benefit of patients. Particularly with cardiovascular surgeries, robotic surgical systems enable surgeons to perform delicate procedures on a beating heart, avoiding the complications of cardiac arrest. This advantage comes with the price of having to deal with a dynamic target which presents technical challenges for the surgical system. In this work, we propose a solution for cardiac motion estimation...
January 19, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29350271/development-of-unstable-hips-after-treatment-with-the-t%C3%A3-bingen-splint-mid-term-follow-up-of-83-hip-joints
#11
Hannes Kubo, Hakan Pilge, Karoline Nepp, Bettina Westhoff, Ruediger Krauspe
INTRODUCTION: Early diagnosis and treatment of hip dysplasia are widely accepted as major factors for beneficial outcome. However, modalities for reduction and retention as well as for imaging are currently under clinical investigation. Local and general risk factors, e.g., breech presentation and the family's desire to avoid in-hospital treatment are major concerns in the decision-making process and consultation. For treatment of unstable hips in newborns the treatment with the Tübingen splint has proven good results in recent studies...
January 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29350145/development-of-a-pediatric-ebola-predictive-score-sierra-leone1
#12
Felicity Fitzgerald, Kevin Wing, Asad Naveed, Musa Gbessay, J C G Ross, Francesco Checchi, Daniel Youkee, Mohamed Boie Jalloh, David E Baion, Ayeshatu Mustapha, Hawanatu Jah, Sandra Lako, Shefali Oza, Sabah Boufkhed, Reynold Feury, Julia Bielicki, Elizabeth Williamson, Diana M Gibb, Nigel Klein, Foday Sahr, Shunmay Yeung
We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children <13 years of age admitted to 11 Ebola holding units in Sierra Leone during August 2014-March 2015 and performed multivariable logistic regression. Among 1,054 children, 309 (29%) were EVD positive and 697 (66%) EVD negative, with 48 (5%) missing. Contact history, conjunctivitis, and age were the strongest positive predictors for EVD...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350123/-dontrun-a-neurosurgical-trainee-network-network-for-the-advancement-of-clinical-research
#13
J L Groen, E M Bos, J W Berkelbach van der Sprenkel
There is a lot of research into the effectiveness of interventions, but good evidence for many interventions is missing. This is very true of simple and frequently performed treatments. These interventions are often done by trainees in the course of their specialist training, and for this reason they are in a unique position to carry out research into them. There are far fewer high-quality, multicentre clinical trials in the surgical specialisations than in any other specialisation. As trainee neurosurgeons, we are of the opinion that this can be improved upon...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29350112/a-comparison-of-hiv-risk-behaviors-between-young-black-cisgender-men-who-have-sex-with-men-and-young-black-transgender-women-who-have-sex-with-men
#14
Richard A Crosby, Laura F Salazar, Brandon Hill, Leandro Mena
This study compared sexually transmitted infection (STI)-associated risks between young Black cisgender men who have sex with men (YBMSM) and young Black transwomen who have sex with men (YBTWSM). Comparisons pertained to: (1) prevalence of infections; (2) sexual risk; (3) partner-related risks; and (4) socioeconomic marginalization. YBMSM (n = 577) and YBTWSM (n = 32) were recruited from an STI clinic in the USA. Volunteers completed a computer-assisted self-interview and medical records were abstracted for STI/HIV information...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29349773/progestin-only-and-combined-oral-contraceptives-and-receptor-defined-premenopausal-breast-cancer-risk-the-norwegian-women-and-cancer-study
#15
Marit Busund, Nora S Bugge, Tonje Braaten, Marit Waaseth, Charlotta Rylander, Eiliv Lund
Receptor-defined subtypes of breast cancer represent distinct cancer types and have differences in risk factors. Whether the two main hormonal forms of oral contraceptives (OCs); i.e. progestin-only (POC) and combined oral contraceptives (COC), are differentially associated with these subtypes are not well known. The aim of this study was to assess the effect of POC and COC use on hormone receptor-defined breast cancer risk in premenopausal women in a prospective population-based cohort - The Norwegian Women and Cancer study (NOWAC)...
January 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29349758/is-dcis-overrated
#16
Joshua Feinberg, Rachel Wetstone, Dana Greenstein, Patrick Borgen
Ductal carcinoma in situ (DCIS), the noninvasive form of breast cancer (BC), comprises just over 20% of breast cancer cases diagnosed each year in the USA. Most patients are treated with local excision of the disease followed by whole breast radiation therapy. Total mastectomy is not an uncommon approach, and total mastectomy with a contralateral risk-reducing mastectomy has been on the rise in the past decade. In estrogen receptor-positive disease, patients are often offered endocrine ablative therapy with a selective estrogen receptor modulator or an aromatase inhibitor as both treatment and prevention...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29349584/-percutaneous-endoscopic-gastrostomy-in-geriatrics-indications-technique-and-complications
#17
Rainer Wirth
The technique of percutaneous endoscopic gastrostomy (PEG) was introduced in 1979 as a semi-invasive approach for children with the need for a gastric fistula in order to avoid an operative intervention. The suture pull-through method was rapidly established and is now omnipresent. Because scientific evidence is broadly missing, there is some uncertainty about the indications in geriatric medicine. Guidelines do not recommend the insertion of a PEG in patients with severe dementia and malnutrition. Tube feeding is mainly recommended as a temporary method for patients who cannot take oral nutrition for more than 3 days or for whom the energy intake for more than 10 days presumably covers less than 50% of their needs, assuming that the overall prognosis is reasonable...
January 18, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29349537/timing-of-spirometry-may-impact-hospital-length-of-stay-for-cystic-fibrosis-pulmonary-exacerbation
#18
Katelyn Krivchenia, Dmitry Tumin, Christopher J Nemastil, Joseph D Tobias, Don Hayes
PURPOSE: The optimal timing of spirometry during hospitalization for acute pulmonary exacerbation (PEx) in patients with cystic fibrosis (CF) is unclear. We retrospectively evaluated whether measuring spirometry earlier during hospitalization was associated with a shorter length of stay (LOS). METHODS: In this retrospective study, we analyzed data from the electronic medical record of CF patients 6 years of age and older admitted to a single center for acute PEx requiring IV antibiotic therapy between 2009 and 2016...
January 18, 2018: Lung
https://www.readbyqxmd.com/read/29349215/public-health-and-the-economy-could-be-served-by-reallocating-medical-expenditures-to-social-programs
#19
Linda Diem Tran, Frederick J Zimmerman, Jonathan E Fielding
As much as 30% of US health care spending in the United States does not improve individual or population health. To a large extent this excess spending results from prices that are too high and from administrative waste. In the public sector, and particularly at the state level, where budget constraints are severe and reluctance to raise taxes high, this spending crowds out social, educational, and public-health investments. Over time, as spending on medical care increases, spending on improvements to the social determinants of health are starved...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29349094/upper-extremity-functional-status-of-female-youth-softball-pitchers-using-the-kerlan-jobe-orthopaedic-clinic-questionnaire
#20
Kaila A Holtz, Russell J O'Connor
Background: Softball is a popular sport with a high incidence of upper extremity injuries. The Kerlan-Jobe Orthopaedic Clinic (KJOC) questionnaire is a validated performance and functional assessment tool used in overhead athletes. Upper extremity pain patterns and baseline KJOC scores have not been reported for active female youth softball pitchers. Purpose/Hypothesis: The purpose of this study was to establish the prevalence of upper extremity pain and its effect in female youth softball pitchers over a competitive season...
January 2018: Orthopaedic Journal of Sports Medicine
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