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https://www.readbyqxmd.com/read/28346965/point-of-care-coagulation-tests-monitoring-of-direct-oral-anticoagulants-and-their-reversal-therapy-state-of-the-art
#1
Giacomo E Iapichino, Paolo Bianchi, Marco Ranucci, Ekaterina Baryshnikova
Direct oral anticoagulants (DOACs) exert similar anticoagulant effects to vitamin K antagonists and are increasingly used worldwide. Nevertheless, an evidence-based approach to patients receiving DOACs when any unplanned urgent surgery or bleeding (either spontaneous or traumatic) occurs is still missing. In this review, we investigate the role of point-of-care coagulation tests when other, more specific tests are not available. Indeed, thromboelastography and activated clotting time can detect dabigatran-induced coagulopathy, while their accuracy is limited for apixaban and rivaroxaban, mostly in cases of low drug plasma concentrations...
March 27, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28346938/star-formation-inside-a-galactic-outflow
#2
R Maiolino, H R Russell, A C Fabian, S Carniani, R Gallagher, S Cazzoli, S Arribas, F Belfiore, E Bellocchi, L Colina, G Cresci, W Ishibashi, A Marconi, F Mannucci, E Oliva, E Sturm
Recent observations have revealed massive galactic molecular outflows that may have the physical conditions (high gas densities) required to form stars. Indeed, several recent models predict that such massive outflows may ignite star formation within the outflow itself. This star-formation mode, in which stars form with high radial velocities, could contribute to the morphological evolution of galaxies, to the evolution in size and velocity dispersion of the spheroidal component of galaxies, and would contribute to the population of high-velocity stars, which could even escape the galaxy...
March 27, 2017: Nature
https://www.readbyqxmd.com/read/28346900/growing-season-variability-in-carbon-dioxide-exchange-of-irrigated-and-rainfed-soybean-in-the-southern-united-states
#3
Pradeep Wagle, Prasanna H Gowda, Saseendran S Anapalli, Krishna N Reddy, Brian K Northup
Measurement of carbon dynamics of soybean (Glycine max L.) ecosystems outside Corn Belt of the United States (U.S.) is lacking. This study examines the seasonal variability of net ecosystem CO2 exchange (NEE) and its components (gross primary production, GPP and ecosystem respiration, ER), and relevant controlling environmental factors between rainfed (El Reno, Oklahoma) and irrigated (Stoneville, Mississippi) soybean fields in the southern U.S. during the 2016 growing season. Grain yield was about 1.6tha(-1) for rainfed soybean and 4...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346734/when-meta-analysis-fails-a-case-about-stomata
#4
Christian Körner
In a recent paper, Yan et al. (2017) offered a statistical re-assessment of the response of stomata density in leaves to environmental conditions using published data sets, including (pre-)historical time series, environmental gradients and manipulative experiments. The authors arrive at a few trends and they conclude that the issue is complicated, responses vary and there is a need for better research. This meta-analysis, like many previous ones, suffered from insufficient or missing data stratification and employing inappropriate assumptions...
March 27, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28346688/how-far-do-neotropical-primates-disperse-seeds
#5
Lisieux F Fuzessy, Charles H Janson, Fernando A O Silveira
Seed dispersal distance (SDD) is a vital component of vertebrate-mediated seed dispersal process: the average distance at which seeds are deposited away from the parent plant represents the starting template of plant regeneration. We present a simple model to explain and predict observed measures of average dispersal distance and we hypothesize that it is a consequence of how long seeds are retained in the disperser's gut, how rapidly the disperser moves per unit time and how twisted the animal travel path is relative to the straight-line distance moved away from the seed source...
March 27, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28346599/genomics-health-disparities-and-missed-opportunities-for-the-nation-s-research-agenda
#6
Kathleen McGlone West, Erika Blacksher, Wylie Burke
No abstract text is available yet for this article.
March 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28346519/views-of-senior-health-personnel-about-quality-of-emergency-obstetric-care-a-qualitative-study-in-nigeria
#7
Friday Okonofua, Abdullahi Randawa, Rosemary Ogu, Kingsley Agholor, Ola Okike, Rukayat Adeola Abdus-Salam, Mohammed Gana, Eghe Abe, Adetoye Durodola, Hadiza Galadanci
BACKGROUND: Late arrival in hospital by women experiencing pregnancy complications is an important background factor leading to maternal mortality in Nigeria. The use of effective and timely emergency obstetric care determines whether women survive or die, or become near-miss cases. Healthcare managers have the responsibility to deploy resources for implementing emergency obstetric care. OBJECTIVES: To determine the nature of institutional policies and frameworks for managing obstetric complications and reducing maternal deaths in Nigeria...
2017: PloS One
https://www.readbyqxmd.com/read/28345986/children-and-young-people-with-diabetes-recognition-and-management
#8
Hamish Hamilton, Grace Knudsen, Camelia Laura Vaina, Michelle Smith, Siba Prosad Paul
Diabetes mellitus (type 1) is an autoimmune condition leading to absolute insulin deficiency resulting in hyperglycaemia and its associated manifestations. It is the most common type of diabetes seen in children, characterised by the 4Ts (toilet, thinner, thirsty, tired). The signs and symptoms can sometimes be non-specific and a delay or missed diagnosis may be catastrophic to the health of the child. Children with an established diagnosis of diabetes often present to the health service with issues such as hypoglycaemia, hyperglycaemia, or diabetic ketoacidosis...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28345822/the-optimal-cut-off-level-of-the-fecal-immunochemical-test-for-colorectal-cancer-screening-in-a-country-with-limited-colonoscopy-resources-a-multi-center-study-from-thailand
#9
Satimai Aniwan, Thawee Ratanachu Ek, Supot Pongprasobchai, Julajak Limsrivilai, Ong Ard Praisontarangkul, Pises Pisespongsa, Pisaln Mairiang, Apichat Sangchan, Jaksin Sottisuporn, Naruemon Wisedopas, Pinit Kullavanijaya, Rungsun Rerknimitr
Background: Selecting the cut-off point for the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening programs is of prime importance. The balance between the test performance for detecting advanced neoplasia and the available colonoscopy resources should be considered. We aimed to identify the optimal cut-off of FIT for advanced neoplasia in order to minimize colonoscopy burden. Methods: We conducted a multi-center study in 6 hospitals from diverse regions of Thailand. Asymptomatic participants, aged 50-75 years, were tested with one-time quantitative FIT (OC-SENSOR, Eiken Chemical Co...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345575/missed-punctal-foreign-body-a-cause-for-chronic-ocular-irritation
#10
Tanie Natung, Wakaru Shullai, P K Goswami
No abstract text is available yet for this article.
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345445/the-role-of-patient-financial-assistance-programs-in-reducing-costs-for-cancer-patients
#11
Leah L Zullig, Steven Wolf, Lisa Vlastelica, Veena Shankaran, S Yousuf Zafar
BACKGROUND: Limited transparency exists regarding eligibility and benefits for patient financial assistance programs (PAPs). OBJECTIVE: To describe oral anticancer medication costs, insurance coverage, and the degree of financial assistance provided by PAPs. METHODS: This was a retrospective study of prescription anticancer medication costs and PAP coverage. The study used data from an academic cancer center's specialty pharmacy. Medication, cost, and coverage data were collected from the specialty pharmacy database for prescriptions filled from January 2013 to November 2015...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345358/-instead-of-popping-pills-perhaps-you-should-add-frog-breathing-experiences-of-glossopharyngeal-insufflation-breathing-for-people-with-cervical-spinal-cord-injury
#12
Malin Nygren-Bonnier, Jens Werner, Gabriele Biguet, Sverker Johansson
BACKGROUND: People with cervical spinal cord injury have impaired function of the respiratory muscles, which results in reduced ventilation. Glossopharyngeal insufflation/breathing increases total lung capacity and improves cough function, however, knowledge of the experiences regarding learning and practicing glossopharyngeal insufflation in everyday life is missing. PURPOSE: To describe and explore the experiences of learning and practicing glossopharyngeal insufflation among people with cervical spinal cord injury...
March 27, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28345277/evolution-of-antigenic-diversity-in-the-tick-transmitted-bacterium-borrelia-afzelii-a-role-for-host-specialization
#13
Lars Råberg, Åsa Hagström, Martin Andersson, Simona Bartkova, Kristin Scherman, Maria Strandh, Barbara Tschirren
Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host-pathogen coevolution, and/or host specialization. Here, we investigate if host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick-transmitted bacterium Borrelia afzelii. We determined prevalence and infection intensity of ospC strains in naturally infected wild mammals (rodents and shrews) by 454 amplicon sequencing in combination with qPCR...
March 26, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28345263/nmr-solution-structure-of-the-red-subdomain-of-the-sleeping-beauty-transposase
#14
Tatiana A Konnova, Christopher M Singer, Irina V Nesmelova
DNA transposons can be employed for stable gene transfer in vertebrates. The Sleeping Beauty (SB) DNA transposon has been recently adapted for human application and is being evaluated in clinical trials, however its molecular mechanism is not clear. SB transposition is catalyzed by the transposase enzyme, which is a multi-domain protein containing the catalytic and the DNA-binding domains. The DNA-binding domain of SB transposase contains two structurally independent subdomains, PAI and RED. Recently, the structures of the catalytic domain and the PAI subdomain have been determined, however no structural information on the RED subdomain and its interactions with DNA has been available...
March 27, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28345213/caries-experience-of-children-in-primary-schools-with-long-term-tooth-brushing-programs-a-pilot-australian-study
#15
T Cakar, L Harrison-Barry, M L Pukallus, S Kazoullis, W K Seow
OBJECTIVE: The aim of this study was to evaluate a primary school-based tooth brushing (TB) program conducted in a low socio-economic area of Queensland, Australia, to determine its effectiveness in reducing caries. METHODS: Records kept at the central dental clinic of the district were used to analyse the caries experience (decayed, missing, filled teeth [dmft/DMFT]) and caries prevalence in children from two schools with long-term TB programs (TB) (N=1191) and three Non-TB schools (N=553)...
March 26, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28345139/utility-of-%C3%AE-hcg-monitoring-in-the-follow-up-of-medical-management-of-miscarriage
#16
Scott G Petersen, Anneliese R Perkins, Kristen S Gibbons, Julia I Bertolone, Kassam Mahomed
OBJECTIVE: To evaluate the percentage change in total βeta-unit human chorionic gonadotropin (βhCG) levels (%ΔβhCG) in the prediction of treatment outcomes following intravaginal misoprostol for missed miscarriage before 13 weeks. METHODS: A secondary analysis of a randomised controlled study of medical management of miscarriage was performed. Total βhCG levels were collected before misoprostol (baseline) and after a planned seven day interval (follow-up), when a transvaginal ultrasound (TVUS) reported a gestational sac as present or not...
March 27, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28345007/partial-occupancy-binders-identified-by-the-pan-dataset-density-analysis-method-offer-new-chemical-opportunities-and-reveal-cryptic-binding-sites
#17
Nicholas M Pearce, Anthony R Bradley, Tobias Krojer, Brian D Marsden, Charlotte M Deane, Frank von Delft
Crystallographic fragment screening uses low molecular weight compounds to probe the protein surface and although individual protein-fragment interactions are high quality, fragments commonly bind at low occupancy, historically making identification difficult. However, our new Pan-Dataset Density Analysis method readily identifies binders missed by conventional analysis: for fragment screening data of lysine-specific demethylase 4D (KDM4D), the hit rate increased from 0.9% to 10.6%. Previously unidentified fragments reveal multiple binding sites and demonstrate: the versatility of crystallographic fragment screening; that surprisingly large conformational changes are possible in crystals; and that low crystallographic occupancy does not by itself reflect a protein-ligand complex's significance...
May 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28344910/gravity-stress-radiograph-revealing-instability-at-the-first-metatarso-cuneiform-joint-in-lisfranc-injury
#18
Pejma Shazadeh Safavi, William Weiss, Vinod Panchbhavi
Lisfranc injuries are commonly missed in the acute setting, largely due to subtle findings that often require weightbearing radiographs or more complex imaging for diagnosis. The long-term consequences of missed injuries are debilitating osteoarthritis of the midfoot, but this may be prevented with appropriate diagnosis and treatment. This case study presents a Lisfranc injury initially diagnosed by gravity stress radiograph. While used for other injuries, there is no literature on the use of gravity stress radiographs for diagnosis of Lisfranc injuries...
February 7, 2017: Curēus
https://www.readbyqxmd.com/read/28344908/a-cross-sectional-survey-on-health-related-quality-of-life-of-elementary-school-students-using-the-korean-version-of-the-eq-5d-y
#19
Sang-Kyu Kim, Min-Woo Jo, Seon-Ha Kim
BACKGROUND AND OBJECTIVE: The Korean version of the EQ-5D-Y was launched in 2015 by the EuroQol group. Currently, there is no HRQOL data obtained by using the EQ-5D-Y in Korea. This study aimed to measure health-related quality of life of Korean elementary school students using the EQ-5D-Y. METHODS: Elementary school students were recruited from 11 primary schools in Gyungbuk, South Korea. The EQ-5D-Y was self-administered in the sample population. Demographic characteristics were collected from the subjects' parents or guardians...
2017: PeerJ
https://www.readbyqxmd.com/read/28344795/validation-of-a-tool-predicting-important-findings-on-computed-tomography-among-crohn-s-disease-patients
#20
REVIEW
Shail M Govani, Akbar K Waljee, Keith E Kocher, Jason M Swoger, Melissa Saul, Peter Dr Higgins
BACKGROUND: Patients with Crohn's disease (CD) are frequently subjected to computed tomography (CT) in the emergency department (ED). This young population is at higher risk of malignancy from radiation exposure. OBJECTIVES: We aimed to validate a decision tool predicting complications (perforation, abscess or other serious finding) on imaging at two sites. METHODS: We conducted a retrospective review of CT outcomes among patients with CD with ED visits at two tertiary care centers...
March 2017: United European Gastroenterology Journal
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