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https://www.readbyqxmd.com/read/29792918/translational-omics-future-potential-and-current-challenges-in-precision-medicine
#1
Arsalan Wafi, Reza Mirnezami
Rapid advances in computational science and biotechnology are paving the way for precision medicine - a vision in next-generation healthcare that promises to provide a care package uniquely tailored to each individual's molecular make-up. Until relatively recently, the focus has been firmly centred around the genome; however, over the past two decades there has been a surge in the study of molecular activity within other biological domains (proteome/transcriptome/metabolome) involved in health and pathogenesis...
May 21, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29791967/global-emergency-medicine-a-review-of-the-literature-from-2017
#2
Torben K Becker, Indi Trehan, Alison Schroth Hayward, Braden J Hexom, Sean M Kivlehan, Kevin M Lunney, Payal Modi, Maxwell Osei-Ampofo, Amelia Pousson, Daniel K Cho, Adam C Levine
OBJECTIVES: The Global Emergency Medicine Literature Review (GEMLR) conducts an annual search of peer-reviewed and gray literature relevant to global emergency medicine (EM) to identify, review, and disseminate the most important new research in this field to a global audience of academics and clinical practitioners. METHODS: This year, 17,722 articles written in three languages were identified by our electronic search. These articles were distributed among 20 reviewers for initial screening based on their relevance to the field of global EM...
May 23, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29791733/implementation-research-for-early-childhood-development-programming-in-humanitarian-contexts
#3
Katie Maeve Murphy, Hirokazu Yoshikawa, Alice J Wuermli
Young children living in conditions of war, disaster, and displacement are at high risk for developmental difficulties that can follow them throughout their lives. While there is robust evidence supporting the need for early childhood development (ECD) in humanitarian settings, implementation of ECD programming remains sparse, largely due to the lack of evidence of how and why these programs can improve outcomes in humanitarian settings. In order to build the evidence base for ECD in humanitarian settings, we review the current state of implementation research for ECD programming (targeting children 0-8) in humanitarian settings, through a literature review and a series of key informant interviews...
May 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29785204/using-digital-health-to-enable-ethical-health-research-in-conflict-and-other-humanitarian-settings
#4
REVIEW
Eric D Perakslis
Conducting research in a humanitarian setting requires quantifiable quality measures to ensure ethical study conduct. Digital health technologies are proven to improve research study quality and efficacy via automated data collection, improvement of data reliability, fidelity and resilience and by improved data provenance and traceability. Additionally, digital health methodologies can improve patient identity, patient privacy, study transparency, data sharing, competent informed consent, and the confidentiality and security of humanitarian operations...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29783180/reprint-of-cling-film-plastic-wrap-an-innovation-for-dead-body-packaging-preservation-and-transportation-by-first-responders-as-a-replacement-for-cadaver-body-bag-in-large-scale-disasters
#5
Lay See Khoo, Poh Soon Lai, Mohd Hilmi Saidin, Zahari Noor, Mohd Shah Mahmood
Cadaver body bags are the conventional method to contain a human body or human remains, which includes the use for storage and transportation of the deceased at any crime scene or disaster scene. During disasters, most often than not, the first responders including the police will be equipped with cadaver body bags to do scene processing of human remains and collection of personal belongings at the disaster site. However, in an unanticipated large scale disasters involving hundreds and thousands of fatalities, cadaver body bags supplies may be scarce...
May 18, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29782631/reflections-on-end-of-life-dialysis
#6
Manuel Carlos Martins Castro
The world population is aging and diseases such as diabetes mellitus and systemic arterial hypertension are increasing the risk of patients developing chronic kidney disease, leading to an increase in the prevalence of patients on dialysis. The expansion of health services has made it possible to offer dialysis treatment to an increasing number of patients. At the same time, dialysis survival has increased considerably in the last two decades. Thus, patients on dialysis are becoming more numerous, older and with greater number of comorbidities...
May 17, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29776098/effect-of-multiplicative-noise-on-stationary-stochastic-process
#7
A V Kargovsky, A Yu Chikishev, O A Chichigina
An open system that can be analyzed using the Langevin equation with multiplicative noise is considered. The stationary state of the system results from a balance of deterministic damping and random pumping simulated as noise with controlled periodicity. The dependence of statistical moments of the variable that characterizes the system on parameters of the problem is studied. A nontrivial decrease in the mean value of the main variable with an increase in noise stochasticity is revealed. Applications of the results in several physical, chemical, biological, and technical problems of natural and humanitarian sciences are discussed...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775144/the-economic-consequences-of-neurosurgical-disease-in-low-and-middle-income-countries
#8
Niclas Rudolfson, Michael C Dewan, Kee B Park, Mark G Shrime, John G Meara, Blake C Alkire
OBJECTIVE The objective of this study was to estimate the economic consequences of neurosurgical disease in low- and middle-income countries (LMICs). METHODS The authors estimated gross domestic product (GDP) losses and the broader welfare losses attributable to 5 neurosurgical disease categories in LMICs using two distinct economic models. The value of lost output (VLO) model projects annual GDP losses due to neurosurgical disease during 2015-2030, and is based on the WHO's "Projecting the Economic Cost of Ill-health" tool...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29768401/near-real-time-forecasting-for-cholera-decision-making-in-haiti-after-hurricane-matthew
#9
Damiano Pasetto, Flavio Finger, Anton Camacho, Francesco Grandesso, Sandra Cohuet, Joseph C Lemaitre, Andrew S Azman, Francisco J Luquero, Enrico Bertuzzo, Andrea Rinaldo
Computational models of cholera transmission can provide objective insights into the course of an ongoing epidemic and aid decision making on allocation of health care resources. However, models are typically designed, calibrated and interpreted post-hoc. Here, we report the efforts of a team from academia, field research and humanitarian organizations to model in near real-time the Haitian cholera outbreak after Hurricane Matthew in October 2016, to assess risk and to quantitatively estimate the efficacy of a then ongoing vaccination campaign...
May 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29764102/assessment-of-the-effects-of-economic-sanctions-on-iranians-right-to-health-by-using-human-rights-impact-assessment-tool-a-systematic-review
#10
Fatemeh Kokabisaghi
BACKGROUND: Over the years, economic sanctions have contributed to violation of right to health in target countries. Iran has been under comprehensive unilateral economic sanctions by groups of countries (not United Nations [UN]) in recent years. They have been intensified from 2012 because of international community's uncertainty about peaceful purpose of Iran's nuclear program and inadequacy of trust-building actions of this country. This review aimed to identify the humanitarian effects of the sanctions on the right of Iranians to health and the obligations of Iran and international community about it...
January 20, 2018: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29763433/injury-and-death-during-the-isis-occupation-of-mosul-and-its-liberation-results-from-a-40-cluster-household-survey
#11
Riyadh Lafta, Maha A Al-Nuaimi, Gilbert Burnham
BACKGROUND: Measurement of mortality and injury in conflict situations presents many challenges compared with stable situations. However, providing information is important to assess the impact of conflict on populations and to estimate humanitarian needs, both in the immediate and longer term. Mosul, Iraq's second largest city, was overrun by fighters of the Islamic State of Iraq and Syria (ISIS) on June 4, 2014. In this study, we conducted household surveys to measure reported deaths, injuries, and kidnappings in Mosul, Iraq, both during the occupation of the city by fighters of ISIS and the months of Iraqi military action known as the liberation...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29756402/-friends-that-last-a-lifetime-the-importance-of-emotions-amongst-volunteers-working-with-refugees-in-calais
#12
Mark Doidge, Elisa Sandri
The European 'refugee crisis' has generated a broad movement of volunteers offering their time and skills to support refugees across the continent, in the absence of nation states. This article focuses on volunteers who helped in the informal refugee camp in Calais called the 'Jungle'. It looks at the importance of emotions as a motivating factor for taking on responsibilities that are usually carried out by humanitarian aid organizations. We argue that empathy is not only the initial motivator for action, but it also sustains the voluntary activity as volunteers make sense of their emotions through working in the camp...
May 13, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29749280/beyond-china-s-drug-century-yunnan-s-first-therapeutic-community-and-narratives-of-drug-treatment-and-mental-health-care
#13
Sandra Teresa Hyde
China is experiencing rapid cultural change and new forms of sociability that are accompanied by social problems and novel humanitarian interventions that have been formulated to address those problems. The pressure related to the rapid transformation of the countryside into mid-level cities has led to recreational drug-use as a means of escape. These illegal drugs have greased the wheels of what I call an affective biopolitics that has influenced Chinese citizens. Carlos Rojas argues that development in China results from the effects of discrete protocols, or practices that stem from tensions between capital and labor, governmentality and biopolitics, and nationalism and globalization...
January 1, 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29747641/the-syrian-conflict-a-case-study-of-the-challenges-and-acute-need-for-medical-humanitarian-operations-for-women-and-children-internally-displaced-persons
#14
Rahma Aburas, Amina Najeeb, Laila Baageel, Tim K Mackey
BACKGROUND: After 7 years of increasing conflict and violence, the Syrian civil war now constitutes the largest displacement crisis in the world, with more than 6 million people who have been internally displaced. Among this already-vulnerable population group, women and children face significant challenges associated with lack of adequate access to maternal and child health (MCH) services, threatening their lives along with their immediate and long-term health outcomes. DISCUSSION: While several health and humanitarian aid organizations are working to improve the health and welfare of internally displaced Syrian women and children, there is an immediate need for local medical humanitarian interventions...
May 11, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29744197/influence-of-full-mouth-rehabilitation-on-oral-health-related-quality-of-life-among-disabled-children
#15
Abeer M Al-Nowaiser, Abdulaziz S Al Suwyed, Khalid H Al Zoman, Asirvatham A Robert, Tarfa Al Brahim, Sebastian G Ciancio, Sultan A Al Mubarak, Omar A El Meligy
The efficacy of full mouth rehabilitation (FMR) on oral health-related quality of life of physically disabled children was assessed. This prospective study was performed at Dental Department of Sultan Bin Abdulaziz Humanitarian City, Riyadh, and King Abdulaziz University Hospital, Jeddah, Saudi Arabia, during May 2012 to September 2014. A total of 186 physically disabled children aged 11-14 years were assigned to a test group (n = 97) or a control group (n = 89). FMR was applied for test group children at baseline and 3 months' visits, whereas those in the control group did not receive FMR...
October 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29741950/humanitarian-goals-financial-constraints-and-residual-questions-of-america-s-first-vaccine-institute
#16
Andrea Rusnock
No abstract text is available yet for this article.
June 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29740973/findings-from-a-cluster-randomised-trial-of-unconditional-cash-transfers-in-niger
#17
Victoria L Sibson, Carlos S Grijalva-Eternod, Garba Noura, Julia Lewis, Kwanli Kladstrup, Hassan Haghparast-Bidgoli, Jolene Skordis-Worrall, Tim Colbourn, Joanna Morrison, Andrew J Seal
Unconditional cash transfers (UCTs) are used as a humanitarian intervention to prevent acute malnutrition, despite a lack of evidence about their effectiveness. In Niger, UCT and supplementary feeding are given during the June-September "lean season," although admissions of malnourished children to feeding programmes may rise from March/April. We hypothesised that earlier initiation of the UCT would reduce the prevalence of global acute malnutrition (GAM) in children 6-59 months old in beneficiary households and at population level...
May 8, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29736275/use-of-verbal-autopsy-and-social-autopsy-in-humanitarian-crises
#18
Lisa-Marie Thomas, Lucia D'Ambruoso, Dina Balabanova
Introduction: Two billion people live in countries affected by conflict, violence and fragility. These are exceptional situations in which mortality shifts dramatically and in which civil registration and vital statistics systems are often weakened or cease to function. Verbal autopsy and social autopsy (VA and SA) are methods used to assign causes of death and understand the contexts in which these occur, in settings where information is otherwise unavailable. This review sought to explore the use of VA and SA in humanitarian crises, with a focus on how these approaches are used to inform policy and programme responses...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29736272/a-long-way-to-go-a-systematic-review-to-assess-the-utilisation-of-sexual-and-reproductive-health-services-during-humanitarian-crises
#19
Neha S Singh, Sarindi Aryasinghe, James Smith, Rajat Khosla, Lale Say, Karl Blanchet
Introduction: Women and girls are affected significantly in both sudden and slow-onset emergencies, and face multiple sexual and reproductive health (SRH) challenges in humanitarian crises contexts. There are an estimated 26 million women and girls of reproductive age living in humanitarian crises settings, all of whom need access to SRH information and services. This systematic review aimed to assess the utilisation of services of SRH interventions from the onset of emergencies in low- and middle-income countries...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29735579/epidemiology-of-genotype-1-and-2-hepatitis-e-virus-infections
#20
Kenrad E Nelson, Alain B Labrique, Brittany L Kmush
Hepatitis E virus (HEV) genotypes 1 and 2 are responsible for the majority of acute viral hepatitis infections in endemic areas in South Asia and sub-Saharan Africa. In addition to frequent sporadic illnesses throughout the year, these viruses often cause large epidemics in association with monsoon rains in Asia or during humanitarian crises in Africa. Clinical hepatitis commonly involves adults more often than young children, with an overall mortality of ∼1%. However, the mortality among pregnant women is often 30% or higher...
May 7, 2018: Cold Spring Harbor Perspectives in Medicine
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