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C Gómez-Anquela, T García-Mendiola, José M Abad, M Pita, F Pariente, E Lorenzo
Nanometric size gold nanoparticles capped with thiotic acid are used to coordinate with the Zn (II) present in the catalytic center of Alcohol Dehydrogenase (ADH). In combination with the NADH oxidation molecular catalyst Azure A, electrografted onto carbon screen-printed electrodes, they are used as scaffold electrodes for the construction of a very efficient ethanol biosensor. The final biosensing device exhibits a highly efficient ethanol oxidation with low overpotential of -0.25 V besides a very good analytical performance with a detection limit of 0...
December 2015: Bioelectrochemistry
D Pariente, S Franchi-Abella
Two-thirds of pediatric liver tumors are malignant, but pseudotumors such as abscesses or hematoma can simulate a tumor. The pediatrician is often the first to discover a hepatic mass in a child. The diagnostic gamut varies depending on the child's age. Before the age of three years, the main diagnoses are hepatoblastoma and hemangioma, while after the age of three, hepatocarcinoma, sarcoma, focal nodular hyperplasia, and adenoma are more frequent. The laboratory findings to search for are alpha-fetoprotein whatever the age (increased in hepatoblastoma and hepatocarcinoma), beta-hCG, and urinary catecholamines in infants...
July 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Omer Bar-Yosef, Josef Haik, Ohad Hilly, Ran Levy, Ori Efrati, Yoram Bujanover, Brigitte Kochavi, Clara Pariente, Hannah Kanety, Oren Weissman, Dalit Modan-Moses
OBJECTIVE: Leptin, adiponectin, and ghrelin have diverse roles in the control of inflammation and metabolism in a normal state as well as in a chronic disease state. The aim of this study was to evaluate their role in the extreme metabolic and proinflammatory state after burn injury and during the initial weeks of recovery. METHODS: A prospective descriptive study in a tertiary care center was undertaken. Patients were comprised of 5 children aged 20-108 months with severe burn injury; burn size ranged from 15%-36% of total body surface area...
June 2014: Wounds: a Compendium of Clinical Research and Practice
Ofer Beharier, Ilana Shoham-Vardi, Gali Pariente, Ruslan Sergienko, Roy Kessous, Yael Baumfeld, Irit Szaingurten-Solodkin, Eyal Sheiner
CONTEXT: Gestational diabetes mellitus (GDM) was found to be an independent risk factor for recurrent long-term type 2 diabetes mellitus, cardiovascular morbidity, and vascular endothelial dysfunction. However, data on the link between GDM and future risk for long-term maternal renal disease are limited. OBJECTIVE: The purpose of this study was to investigate whether GDM poses a risk for subsequent long-term maternal renal morbidity. DESIGN: A population-based noninterventional study compared the incidence of future renal morbidity in a cohort of women with and without previous GDM...
April 2015: Journal of Clinical Endocrinology and Metabolism
C Gagniere, L Beaugerie, B Pariente, P Seksik, A Amiot, V Abitbol, M Allez, J Cosnes, H Sokol
BACKGROUND: Infliximab [IFX] and adalimumab [ADA] are effective in Crohn's disease [CD] for induction and maintenance therapy. However, high annual rate of discontinuation for loss of response or intolerance may lead to a switch to another anti-tumor necrosis factor agent. Patients with successive failure to IFX and ADA are becoming more frequent. The aim of this study was to assess the efficacy and the tolerance of re-treatment with IFX in CD patients who successively failed IFX and ADA...
April 2015: Journal of Crohn's & Colitis
Benjamin Pariente, Jean-Yves Mary, Silvio Danese, Yehuda Chowers, Peter De Cruz, Geert D'Haens, Edward V Loftus, Edouard Louis, Julian Panés, Jürgen Schölmerich, Stefan Schreiber, Maurizio Vecchi, Julien Branche, David Bruining, Gionata Fiorino, Matthias Herzog, Michael A Kamm, Amir Klein, Maïté Lewin, Paul Meunier, Ingrid Ordas, Ulrike Strauch, Gian-Eugenio Tontini, Anne-Marie Zagdanski, Cristiana Bonifacio, Jordi Rimola, Maria Nachury, Christophe Leroy, William Sandborn, Jean-Frédéric Colombel, Jacques Cosnes
BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuring disease progression. We developed the Lémann Index and assessed its ability to measure cumulative structural bowel damage in patients with Crohn's disease (CD). METHODS: We performed a prospective, multicenter, international, cross-sectional study of patients with CD evaluated at 24 centers in 15 countries...
January 2015: Gastroenterology
Gali Pariente, C Peles, Zvi H Perri, Yael Baumfeld, Salvatore Andrea Mastrolia, Arie Koifman, Adi Y Weintraub, Reli Hershkovitz
OBJECTIVE: To detect factors that are associated with meconium-stained amniotic fluid (MSAF) among deliveries of small for gestational age (SGA) neonates and to identify perinatal outcomes of deliveries of SGA infants complicated with MSAF. METHODS: A population-based study comparing deliveries of SGA neonates with and without MSAF was conducted. Deliveries occurred during the years 1988-2007 at the Soroka University Medical Center. Risk factors for MSAF among SGA infants were evaluated...
June 2015: Journal of Maternal-fetal & Neonatal Medicine
Gilles Macaigne, Pierre Lahmek, Christophe Locher, Bruno Lesgourgues, Laurent Costes, Max Pierre Nicolas, Anne Courillon-Mallet, Jean-Michel Ghilain, Guy Bellaïche, Stéphanie de Montigny-Lehnardt, Georges Barjonet, René-Louis Vitte, Roger Faroux, Benedicte Lambare, Antoine Fleury, Alexandre Pariente, Stéphane Nahon
OBJECTIVES: To describe the characteristics of a cohort of patients with microscopic colitis (MC; lymphocytic (LC) or collagenous (CC) colitis) and to compare them with patients with functional bowel disorder with diarrhea (FBD-D). METHODS: Between September 2010 and June 2012, patients fulfilling the following inclusion criteria were prospectively included in 26 centers in France: (i) having at least three bowel movements daily with change in stool consistency; (ii) duration of abnormal bowel habit >4 weeks; and (iii) normal or near-normal colonoscopy...
September 2014: American Journal of Gastroenterology
Gali Pariente, Eyal Sheiner, Roy Kessous, Sherf Michael, Ilana Shoham-Vardi
OBJECTIVE: To investigate whether delivering a small-for-gestational-age (SGA) newborn is a risk factor for subsequent long-term maternal cardiovascular morbidity. METHODS: Data were analyzed from consecutive pregnant women who delivered at Soroka University Medical Center, Beer-Sheva, Israel, between 1988 and 1999, and were followed-up retrospectively until 2010. Long-term cardiovascular morbidity was compared among women with and without SGA neonates. RESULTS: During the study period, 47 612 deliveries met the inclusion criteria, and 4411 (9...
October 2013: International Journal of Gynaecology and Obstetrics
Roy Kessous, Ilana Shoham-Vardi, Gali Pariente, Michael Sherf, Eyal Sheiner
OBJECTIVE: To investigate whether a diagnosis of gestational diabetes mellitus (GDM) is a risk factor for subsequent long-term cardiovascular morbidity. DESIGN: A population-based study. SETTING: Soroka University Medical Center, a tertiary centre in the southern region of Israel. PATIENTS: A cohort of women with and without a diagnosis of GDM who delivered during the years 1988-1999 with a follow-up period until 2010...
August 2013: Heart: Official Journal of the British Cardiac Society
M Revenga-Parra, C Gómez-Anquela, T García-Mendiola, E Gonzalez, F Pariente, E Lorenzo
We report the in situ generation of aryl diazonium cations of Azure A, a redox-active phenothiazine dye, by reaction between the corresponding aromatic aminophenyl group and sodium nitrite in 0.1 M HCl. The subsequent electrochemical reduction of these dye diazonium salts gives rise to conductive electrografted films onto screen-printed carbon (SPC) electrodes. The resulting Azure A films have a very stable and reversible electrochemical response and exhibit potent and persistent electrocatalytic behavior toward NADH oxidation...
October 17, 2012: Analytica Chimica Acta
Yonit Krakauer, Gali Pariente, Ruslan Sergienko, Arnon Wiznitzer, Eyal Sheiner
OBJECTIVE: To investigate factors associated with latent syphilis and pregnancy outcome among women with latent syphilis. METHODS: A retrospective population-based study was conducted to compare all pregnancies among women with and without latent syphilis at Soroka University Medical Center, Be'er-Sheva, Israel, between 1988 and 2010. Stratified analysis using a multiple logistic regression model was performed to control for confounders. RESULTS: Of the 219656 deliveries during the study period, 159 (0...
July 2012: International Journal of Gynaecology and Obstetrics
Géraldine Héry, Stéphanie Franchi-Abella, Dalila Habes, Laurence Brugières, Hélène Martelli, Monique Fabre, Danièle Pariente, Frédéric Gauthier, Emmanuel Jacquemin, Sophie Branchereau
BACKGROUND: SIOPEL protocols have recommended liver transplantation for unresectable hepatoblastoma (HBL) after chemotherapy in absence of visible extrahepatic disease. METHODS: This retrospective single center study includes 13 children treated following SIOPEL 3 or 4 protocols who underwent orthotopic liver transplantation (OLT) for HBL between February 2001 and May 2009. RESULTS: Twelve patients had PRETEXT IV HBL, one had PRETEXT II P + HBL, two had pulmonary metastasis at diagnosis...
December 15, 2011: Pediatric Blood & Cancer
Benjamin Pariente, Jacques Cosnes, Silvio Danese, William J Sandborn, Maïté Lewin, Joel G Fletcher, Yehuda Chowers, Geert D'Haens, Brian G Feagan, Toshifumi Hibi, Daniel W Hommes, E Jan Irvine, Michael A Kamm, Edward V Loftus, Edouard Louis, Pierre Michetti, Pia Munkholm, Tom Oresland, Julian Panés, Laurent Peyrin-Biroulet, Walter Reinisch, Bruce E Sands, Juergen Schoelmerich, Stefan Schreiber, Herbert Tilg, Simon Travis, Gert van Assche, Maurizio Vecchi, Jean-Yves Mary, Jean-Frédéric Colombel, Marc Lémann
Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection...
June 2011: Inflammatory Bowel Diseases
Javier Espino, Águeda Ortiz, Ignacio Bejarano, Graciela M Lozano, Fabian Monllor, Juan F García, Ana B Rodríguez, José A Pariente
OBJECTIVE: To evaluate whether the protective effect of melatonin on H2O2-induced caspase activation and DNA fragmentation depends on the interaction between melatonin and its surface receptors. DESIGN: Laboratory study. SETTING: Center for assisted human reproduction at a Spanish hospital. PATIENT(S): Twenty-one healthy donors. INTERVENTION(S): Human spermatozoa were treated with increasing concentrations of hydrogen peroxide (H2O2; 1 μM, 10 μM, 100 μM, 1 mM) and preincubated with 1 mM melatonin...
June 2011: Fertility and Sterility
T García, M G Fernández-Barrena, M Revenga-Parra, A Núñez, E Casero, F Pariente, J Prieto, E Lorenzo
A screening method for rapid detection of gene mutations directly in polymerase chain reaction (PCR) of genomic DNA is described. The method involves the development of a disposable screen-printed gold electrode modified with a thiolated capture probe directly obtained from denaturated PCR genomic DNA, which recognizes (by hybridization) its fully complementary sequence (wild type), giving a signal, whereas no signal is obtained for single-mismatched target (mutant). The detection of the hybridization event is achieved by changes in the metal redox center electroactivity of the complex [Ru(NH(3))(5) L](2+), where L is [3-(2-phenanthren-9-yl-vinyl)-pyridine], at -0...
October 2010: Analytical and Bioanalytical Chemistry
Jean-François Cadranel, Vincent Di Martino, Guy Lambrey, Catherine Mourlhon, Bernard Nalet, Marie-Laure Anciaux, Christian Richard, Jean-Paul Bigué, Jean-Noël Barjon, Christian Bories, Jean-Claude Barbare, Chantal Halimi, Olivier Ribière, Claude Eugène, Arnaud Pauwels, Sandrine Jeanne, Laurence Donato, Patrice Dumouchel, Alexandre Pariente, Gilles Duverlie, Bruno Devergie, Sylvie Arlot, Dominique Capron
OBJECTIVES: Although there may exist a nosocomial risk of hepatitis C virus (HCV) infection in patients with type 1 or type 2 diabetes, this risk has not been fully investigated thus far and its magnitude is unknown. The aim of this multicenter cross-sectional study was to evaluate the prevalence of, and risk factors for, hepatitis C infection in consecutive hospitalized patients with diabetes and to assess the nosocomial risk and magnitude of HCV infection in these patients. PATIENTS AND METHODS: Consecutive hospitalized patients with diabetes seen in 11 French hepatogastroenterology and diabetology departments were studied...
September 2008: European Journal of Gastroenterology & Hepatology
T García, E Casero, M Revenga-Parra, J Martín-Benito, F Pariente, L Vázquez, E Lorenzo
The preparation of DNA-sensing architectures based on gold nanoparticles (Au-NPs) in conjunction with an "in situ" prepared ruthenium complex as a new route to improve the analytical properties of genosensors is described. In the development of these architectures several strategies to obtain Au-NPs modified gold electrodes (Au-NP/Au) have been essayed, in particular covalent binding and electrochemical deposition from a solution containing Au-NPs previously synthesized. UV-vis absorption measurements in conjunction with transmission electron microscope (TEM) images reveal that the synthesized Au-NPs are stable for at least 4 weeks and have a narrow size distribution...
October 15, 2008: Biosensors & Bioelectronics
Ignacio Bejarano, Graciela M Lozano, Agueda Ortiz, Juan F García, Sergio D Paredes, Ana B Rodríguez, José A Pariente
OBJECTIVE: To determine the role of calcium signaling on apoptosis evoked by the reactive oxygen species H2O2 and by the physiological agonist P in human ejaculated spermatozoa. DESIGN: Laboratory study. SETTING: Center for assisted human reproduction in a hospital in Spain. PATIENT(S): Forty-five healthy volunteers. INTERVENTION(S): Spermatozoa were treated with increasing concentrations of hydrogen peroxide (H2O2; 10 microM, 100 microM, and 1 mM) or with 20 microM of P for 5-120 minutes...
October 2008: Fertility and Sterility
T García, M Revenga-Parra, H D Abruña, F Pariente, E Lorenzo
A ruthenium complex, pentaamine ruthenium [3-(2-phenanthren-9-yl-vinyl)-pyridine] (which we refer to as RuL in the text) generated in situ has been used as a sensitive and selective electrochemical indicator in DNA sensing. The complex incorporates dual functionalities with the Ru center providing a redox probe and the ligand (L) providing a fluorescent tag. The presence of the aromatic groups in the ligand endows the complex with an intercalative character and makes it capable of binding to double-stranded DNA (dsDNA) more efficiently than to single-stranded DNA (ssDNA)...
January 1, 2008: Analytical Chemistry
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