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https://www.readbyqxmd.com/read/28738415/monocarboxylate-transporters-mediate-fluorescein-uptake-in-corneal-epithelial-cells
#1
Yi-Chen Sun, Hau-Min Liou, Po-Ting Yeh, Wei-Li Chen, Fung-Rong Hu
Purpose: To determine the presence of monocarboxylate transporter (MCT) in human and rabbit corneal epithelium and its role in transcellular fluorescein transportation in the cornea. Methods: The presence of MCTs in human and rabbit corneal epithelium was determined by RT-PCR and immunohistochemistry. Intracellular fluorescein uptake experiment was performed using cultured human corneal epithelial cells (HCECs). The involvement of MCT in fluorescein uptake was determined by addition of MCT inhibitors to HCECs and acute dry eye model on New Zealand albino rabbits by spectrophotometry, corneal impression cytology, and external eye photographs...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28738004/bone-marrow-cell-composition-and-morphology-in-healthy-juvenile-female-new-zealand-white-rabbits-oryctolagus-cuniculus
#2
Rebekah M Riedel, Ricardo de Matos, Deanna M W Schaefer
OBJECTIVE To provide contemporary preliminary guidelines for the morphological evaluation of bone marrow in conjunction with CBC results for healthy juvenile (3- to 6-month-old) female New Zealand White rabbits (Oryctolagus cuniculus). ANIMALS 22 female New Zealand White rabbits. PROCEDURES Each rabbit was sedated, and a blood sample (3 mL) was collected from an ear artery for a CBC, after which the rabbit was euthanized. Within 5 minutes after euthanasia, bone marrow samples were obtained from the femur for cytologic and histologic evaluation...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28736912/performance-of-the-index-of-dental-anxiety-and-fear-in-a-population-based-sample-of-adults
#3
H Ibrahim, K M Lyons, J M Armfield, W M Thomson
BACKGROUND: The Index of Dental Anxiety and Fear (IDAF-4C) was introduced to overcome the theoretical and practical shortcomings of previously developed dental fear measures. This new scale has not been tested on population samples other than in its country of origin, Australia. The aim of this study was to validate the IDAF-4C in a different cultural setting and to determine the prevalence and sociodemographic associations of dental anxiety. METHODS: A cross sectional study of a representative New Zealand adult population sample was undertaken...
July 24, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28735815/intensive-lifestyle-intervention-is-particularly-advantageous-in-poorly-controlled-type-2-diabetes
#4
E Sbroma Tomaro, R Pippi, E Reginato, C Aiello, L Buratta, C Mazzeschi, C Perrone, C Ranucci, A Tirimagni, A Russo, C Fatone, C Fanelli, P De Feo
BACKGROUND AND AIMS: It is unknown whether lifestyle change is effective in people with type 2 diabetes with inadequate glucose control. The aim of this study was to asses, in a group of people with type 2 diabetes, the impact of baseline values of glycosylated haemoglobin (HbA1c) on the effects of an intensive lifestyle intervention on metabolic, clinical and strength parameters. METHODS AND RESULTS: 222 people with type 2 diabetes with mean ± standard deviation baseline HBA1c of 7...
June 21, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28735526/the-biocompatibility-of-bone-cements-progress-in-methodological-approach
#5
Carlo Dall'Oca, Tommaso Maluta, Gian Mario Micheloni, Matteo Cengarle, Giampaolo Morbioli, Paolo Bernardi, Andrea Sbarbati, Daniele Degl'Innocenti, Franco Lavini, Bruno Magnan
The ideal bone graft substitute should have certain properties and there are many studies dealing with mixture of polymethylmetacrilate (PMMA) and β-tricalciumphospate (β-TCP) presenting the best characteristics of both. Scanning Electron Microscopy (SEM), for ultra-structural data, resulted a very reliable in vivo model to better understand the bioactivity of a cement and to properly evaluate its suitability for a particular purpose. The present study aims to further improve the knowledge on osteointegration development, using both parameters obtained with the Environmental Scanning Electron Microscopy (ESEM) and focused histological examination...
May 4, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735258/risk-of-rehospitalisation-and-death-for-vulnerable-new-zealand-children
#6
Jane Oliver, Tim Foster, Amanda Kvalsvig, Deborah A Williamson, Michael G Baker, Nevil Pierse
OBJECTIVES: There is considerable need to improve the effectiveness of healthcare to reduce morbidity and mortality. Child hospitalisations are influenced by determinants of health, including the home environment. Our aims were: (1) To investigate whether children hospitalised with potentially avoidable conditions thought to be associated with the home have an increased risk of rehospitalisation and death, (2) To investigate whether children hospitalised with particular subgroups of potentially avoidable conditions have an increased risk of rehospitalisation and death, (3) To assess the usefulness of these subgroups for identifying at-risk children...
July 22, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28735046/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-healthcare-associated-infections-in-australia-and-new-zealand-report-from-an-antimicrobial-surveillance-program-2013-2015
#7
M A Pfaller, D Shortridge, H S Sader, R K Flamm, M Castaneheira
OBJECTIVES: To evaluate the in vitro activity of ceftolozane-tazobactam and comparator agents tested against isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients in Australia and New Zealand with healthcare-associated infection. METHODS: A total of 1,459 gram-negative organisms (440P. aeruginosa and 1,019 Enterobacteriaceae) were consecutively collected from 11 medical centers located in Australia and New Zealand. The organisms were tested for susceptibility by broth microdilution methods as described by the CLSI M07-A10 document and the results interpreted according to EUCAST and CLSI breakpoint criteria...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28733784/environmental-impact-of-coal-mining-and-coal-seam-gas-production-on-surface-water-quality-in-the-sydney-basin-australia
#8
A Ali, V Strezov, P Davies, I Wright
The extraction of coal and coal seam gas (CSG) will generate produced water that, if not adequately treated, will pollute surface and groundwater systems. In Australia, the discharge of produced water from coal mining and related activities is regulated by the state environment agency through a pollution licence. This licence sets the discharge limits for a range of analytes to protect the environment into which the produced water is discharged. This study reports on the impact of produced water from coal mine activities located within or discharging into high conservation environments, such as National Parks, in the outer region of Sydney, Australia...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28733153/unsettling-moods-in-rural-midwifery-practice
#9
Susan Crowther, Liz Smythe, Deb Spence
BACKGROUND: Rural midwifery and maternity care is vulnerable due to geographical isolation, staffing recruitment and retention. Highlighting the concerns within rural midwifery is important for safe sustainable service delivery. METHOD: Hermeneutic phenomenological study undertaken in New Zealand (NZ). 13 participants were recruited in rural regions through snowball technique and interviewed. Transcribed interview data was interpretively analysed. Findings are discussed through the use of philosophical notions and related published literature...
July 18, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28732525/effectiveness-and-cost-effectiveness-of-embedded-simulation-in-occupational-therapy-clinical-practice-education-study-protocol-for-a-randomised-controlled-trial
#10
Christine Imms, Eli Mang Yee Chu, Stephen Guinea, Loretta Sheppard, Elspeth Froude, Rob Carter, Susan Darzins, Samantha Ashby, Susan Gilbert-Hunt, Nigel Gribble, Kelli Nicola-Richmond, Merrolee Penman, Elena Gospodarevskaya, Erin Mathieu, Mark Symmons
BACKGROUND: Clinical placements are a critical component of the training for health professionals such as occupational therapists. However, with growing student enrolments in professional education courses and workload pressures on practitioners, it is increasingly difficult to find sufficient, suitable placements that satisfy program accreditation requirements. The professional accrediting body for occupational therapy in Australia allows up to 200 of the mandatory 1000 clinical placement hours to be completed via simulation activities, but evidence of effectiveness and efficiency for student learning outcomes is lacking...
July 21, 2017: Trials
https://www.readbyqxmd.com/read/28732466/estimation-of-linkage-disequilibrium-and-effective-population-size-in-new-zealand-sheep-using-three-different-methods-to-create-genetic-maps
#11
Vincent Prieur, Shannon M Clarke, Luiz F Brito, John C McEwan, Michael A Lee, Rudiger Brauning, Ken G Dodds, Benoît Auvray
BACKGROUND: Investments in genetic selection have played a major role in the New Zealand sheep industry competitiveness. Selection may erode genetic diversity, which is a crucial factor for the success of breeding programs. Better understanding of linkage disequilibrium (LD) and ancestral effective population size (Ne) through quantifying this diversity and comparison between populations allows for more informed decisions with regards to selective breeding taking population genetic diversity into account...
July 21, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28732086/risk-of-stomach-cancer-in-aotearoa-new-zealand-a-m%C3%A4-ori-population-based-case-control-study
#12
Lis Ellison-Loschmann, Andrew Sporle, Marine Corbin, Soo Cheng, Pauline Harawira, Michelle Gray, Tracey Whaanga, Parry Guilford, Jonathan Koea, Neil Pearce
Māori, the indigenous people of New Zealand, experience disproportionate rates of stomach cancer, compared to non-Māori. The overall aim of the study was to better understand the reasons for the considerable excess of stomach cancer in Māori and to identify priorities for prevention. Māori stomach cancer cases from the New Zealand Cancer Registry between 1 February 2009 and 31 October 2013 and Māori controls, randomly selected from the New Zealand electoral roll were matched by 5-year age bands to cases...
2017: PloS One
https://www.readbyqxmd.com/read/28732031/breast-tissue-ablation-with-irreversible-electroporation-in-rabbits-a-safety-and-feasibility-study
#13
Wenlong Zhang, Wanning Wang, Wei Chai, Xiaomei Luo, Jiannan Li, Jian Shi, Liqi Bi, Lizhi Niu
BACKGROUND AND AIM: Irreversible electroporation (IRE) was confirmed to control several solid tumors effectively in vivo. Our preclinical study aimed to assess the feasibility and safety of IRE in the breast of rabbit. METHODS: Thirty New Zealand white rabbits were randomly divided into 3 groups of 10 rabbits (control group, IRE group A, and B). Two mono-electrode needles were inserted into the breast tissue by percutaneous puncture. Electrocardiogram and vital signs were monitored before, during, and after ablation...
2017: PloS One
https://www.readbyqxmd.com/read/28731903/hepatitis-transmission-risk-in-kidney-transplantation-the-hint-study-a-cross-sectional-survey-of-transplant-clinicians-in-australian-and-new-zealand
#14
Karen M J Waller, Kate R Wyburn, Nicholas A Shackel, Michael J O'Leary, Patrick J Kelly, Angela C Webster
BACKGROUND: Interpreting hepatitis serology and virus transmission risk in transplantation can be challenging. Decisions must balance opportunity to transplant against potential infection transmission. We aimed to survey understanding among the Australian and New Zealand medical transplant workforce of hepatitis risk in kidney donors and recipients. METHODS: An anonymous, self-completed, cross-sectional survey was distributed via electronic mailing lists to Australian and New Zealand clinicians involved in kidney transplantation (2014-2015)...
July 21, 2017: Transplantation
https://www.readbyqxmd.com/read/28731635/university-foodservices-potential-for-providing-environmental-education-to-students
#15
Chelsea Slobbé, Miranda Mirosa, Carla Thomson
AIMS: University foodservices are potentially well placed to foster environmental education in a non-classroom setting and so could have the power to benefit communities through producing environmentally literate graduates. Buy-in from foodservice staff is critical for realising this potential, so understanding what foodservice staff think about their foodservice engaging in the provision of environmental education is essential. The aim of this study was to identify the dominant perspectives held by university foodservice staff about the desirability and realities of fostering environmental education in their workplaces...
April 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731556/dietetic-management-of-gestational-diabetes-in-new-zealand-a-cross-sectional-survey
#16
Robyn L Lawrence, Clare R Wall, Frank H Bloomfield, Caroline A Crowther
AIM: The aim of this study was to evaluate dietetic practice in the management of gestational diabetes in New Zealand, compare this with evidence-based guidelines and determine the need for New Zealand-specific evidence-based nutrition practice guidelines for gestational diabetes. METHODS: A 64-item cross-sectional online survey of New Zealand-registered dietitians providing care to women with gestational diabetes was undertaken. Participants were recruited through Dietitians New Zealand, District Health Boards and private practices across New Zealand...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28730738/the-effects-of-aspirated-thickened-water-on-survival-and-pulmonary-injury-in-a-rabbit-model
#17
Nogah Nativ-Zeltzer, Maggie A Kuhn, Denise M Imai, Ryan P Traslavina, Amanda S Domer, Juliana K Litts, Brett Adams, Peter C Belafsky
OBJECTIVES/HYPOTHESIS: Liquid thickeners are one of the most frequently utilized treatment strategies for persons with oropharyngeal swallowing dysfunction. The effect of commercially available thickeners on lung injury is uncertain. The purpose of this study was to compare the effects of aspiration of water alone, xanthan gum (XG)-thickened water, and cornstarch (CS)-thickened water on survival and lung morphology in a rabbit model. STUDY DESIGN: Animal model. Prospective small animal clinical trial...
July 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28730736/the-importance-of-moral-emotions-for-effective-collaboration-in-culturally-diverse-healthcare-teams
#18
Catherine Cook, Margaret Brunton
Moral emotions shape the effectiveness of culturally diverse teams. However, these emotions, which are integral to determining ethically responsive patient care and team relationships, typically go unrecognised. The contribution of emotions to moral deliberation is subjugated within the technorational environment of healthcare decision-making. Contemporary healthcare organisations rely on a multicultural workforce charged with the ethical care of vulnerable people. Limited extant literature examines the role of moral emotions in ethical decision-making among culturally diverse healthcare teams...
July 20, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28729151/standard-dose-pembrolizumab-in-combination-with-reduced-dose-ipilimumab-for-patients-with-advanced-melanoma-keynote-029-an-open-label-phase-1b-trial
#19
Georgina V Long, Victoria Atkinson, Jonathan S Cebon, Michael B Jameson, Bernie M Fitzharris, Catriona M McNeil, Andrew G Hill, Antoni Ribas, Michael B Atkins, John A Thompson, Wen-Jen Hwu, F Stephen Hodi, Alexander M Menzies, Alexander D Guminski, Richard Kefford, Benjamin Y Kong, Babak Tamjid, Archana Srivastava, Anna J Lomax, Mohammed Islam, Xinxin Shu, Scot Ebbinghaus, Nageatte Ibrahim, Matteo S Carlino
BACKGROUND: Reduced-dose nivolumab in combination with standard-dose ipilimumab improves objective response and progression-free survival compared with standard-dose ipilimumab alone, but increases toxicity. We assessed the safety and anti-tumour activity of standard-dose pembrolizumab in combination with reduced-dose ipilimumab. METHODS: In this open-label, phase 1b trial, we recruited patients from 12 medical centres in Australia, New Zealand, and the USA. Eligible patients were aged at least 18 years, had advanced melanoma, had an Eastern Coooperative Oncology Group performance status of 0 or 1, had measurable disease according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1...
July 17, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28728604/target-d-a-stratified-individually-randomized-controlled-trial-of-the-diamond-clinical-prediction-tool-to-triage-and-target-treatment-for-depressive-symptoms-in-general-practice-study-protocol-for-a-randomized-controlled-trial
#20
Jane Gunn, Caroline Wachtler, Susan Fletcher, Sandra Davidson, Cathrine Mihalopoulos, Victoria Palmer, Kelsey Hegarty, Amy Coe, Elizabeth Murray, Christopher Dowrick, Gavin Andrews, Patty Chondros
BACKGROUND: Depression is a highly prevalent and costly disorder. Effective treatments are available but are not always delivered to the right person at the right time, with both under- and over-treatment a problem. Up to half the patients presenting to general practice report symptoms of depression, but general practitioners have no systematic way of efficiently identifying level of need and allocating treatment accordingly. Therefore, our team developed a new clinical prediction tool (CPT) to assist with this task...
July 20, 2017: Trials
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