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https://www.readbyqxmd.com/read/28337183/are-oligotypes-meaningful-ecological-and-phylogenetic-units-a-case-study-of-microcystis-in-freshwater-lakes
#1
Michelle A Berry, Jeffrey D White, Timothy W Davis, Sunit Jain, Thomas H Johengen, Gregory J Dick, Orlando Sarnelle, Vincent J Denef
Oligotyping is a computational method used to increase the resolution of marker gene microbiome studies. Although oligotyping can distinguish highly similar sequence variants, the resulting units are not necessarily phylogenetically and ecologically informative due to limitations of the selected marker gene. In this perspective, we examine how oligotyping data is interpreted in recent literature, and we illustrate some of the method's constraints with a case study of the harmful bloom-forming cyanobacterium Microcystis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28336758/evaluation-of-a-pharmacist-led-outpatient-direct-oral-anticoagulant-service
#2
Emily Ashjian, Brian Kurtz, Elizabeth Renner, Robert Yeshe, Geoffrey D Barnes
PURPOSE: The impact of a pharmacist-led direct oral anticoagulant (DOAC) service on prescription appropriateness and patient adherence was simultaneously evaluated. METHODS: In this retrospective analysis, patients age 18 years or older for whom a DOAC was prescribed from September 20, 2013, through December 31, 2014, were identified through electronic medical record review of all DOAC prescriptions within the University of Michigan Health System. Patients had their DOAC therapy managed by a pharmacist-led DOAC service or by their physician (usual care)...
April 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28335478/lactational-stage-of-pasteurized-human-donor-milk-contributes-to-nutrient-limitations-for-infants
#3
Christina J Valentine, Georgia Morrow, Amanda Reisinger, Kelly A Dingess, Ardythe L Morrow, Lynette K Rogers
BACKGROUND: Mother's own milk is the first choice for feeding preterm infants, but when not available, pasteurized human donor milk (PDM) is often used. Infants fed PDM have difficulties maintaining appropriate growth velocities. To assess the most basic elements of nutrition, we tested the hypotheses that fatty acid and amino acid composition of PDM is highly variable and standard pooling practices attenuate variability; however, total nutrients may be limiting without supplementation due to late lactational stage of the milk...
March 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28334629/diabetes-knowledge-and-perceptions-among-nursing-students-and-curriculum-differences-in-japan-and-australia-a-cross-sectional-study
#4
Lucie M Ramjan, Hiroko Watanabe, Yenna Salamonson
OBJECTIVES: To investigate the associations between knowledge and perceptions of diabetes mellitus (DM) among nursing students from Japan and Australia; and to compare curriculum differences. RESEARCH DESIGN AND METHODS: Cross-sectional study. Convenience sample of students from Japan (N=78) and Australia (N=85) in their final year were surveyed. Students reported demographic details, and perceptions towards caring for patients with DM. The 23-item Michigan Diabetes Knowledge Test (MDKT) was used to assess general knowledge, and seven additional questions were used to assess DM-related clinical knowledge (CDKT)...
March 16, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28333729/newscap-michigan-law-grants-prescribing-privileges-to-advanced-practice-registered-nurses-aprns
#5
(no author information available yet)
No abstract text is available yet for this article.
April 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28333703/higher-fresh-gas-flow-rates-decrease-tidal-volume-during-pressure-control-ventilation
#6
Shazia Mohammad, Nikolaus Gravenstein, Drew Gonsalves, Terrie Vasilopoulos, Samsun Lampotang
BACKGROUND: We observed that increasing fresh gas flow (FGF) decreased exhaled tidal volume (VT) during pressure control ventilation (PCV). A literature search produced no such description whereby unintended VT changes occur with FGF changes during PCV. METHODS: To model an infant's lungs, 1 lung of a mechanical lung model (Dual Adult TTL 1600; Michigan Instruments, Inc, Grand Rapids, MI) was set at a compliance of 0.0068 L/cm H2O. An Rp50 resistor (27.2 cm H2O/L/s at 15 L/min) simulated normal bronchial resistance...
March 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28323469/social-and-built-environmental-correlates-of-predicted-blood-lead-levels-in-the-flint-water-crisis
#7
Richard Casey Sadler, Jenny LaChance, Mona Hanna-Attisha
OBJECTIVES: To highlight contextual factors tied to increased blood lead level (BLL) risk following the lead-in-water contamination in Flint, Michigan. METHODS: Using geocoded BLL data collected in 2013 and 2015 and areal interpolation, we predicted BLLs at every residential parcel in the city. We then spatially joined social and built environmental variables to link the parcels with neighborhood-level factors that may influence BLLs. RESULTS: When we compared levels before and during the water crisis, we saw the highest estimates of predicted BLLs during the water crisis and the greatest changes in BLLs in neighborhoods with the longest water residence time in pipes (μ = 2...
March 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28322899/permanent-bulbar-urethral-ligation-emerging-treatment-option-for-incontinent-men-with-end-stage-urethra
#8
Maia E VanDyke, Boyd R Viers, Travis J Pagliara, Jeremy M Scott, Nabeel Shakir, Daniel D Dugi, Billy H Cordon, Matthias D Hofer, Allen F Morey
OBJECTIVE: To report our experience with permanent urethral ligation for severe incontinence among men with end-stage urethra. METHODS: From our institutional Artificial Urethral Sphincter (AUS) database of 512 patients from 2010-2016, 10 men underwent permanent urethral ligation with concurrent suprapubic tube (SPT) diversion following recurrent AUS cuff erosion. Clinical characteristics and outcomes were evaluated. Quality of life (QOL) was assessed using the Michigan Incontinence Symptom Index (M-ISI) and the Patient Global Index of Improvement (PGI-I)...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28322578/interview-with-amr-h-sawalha-epigenetics-and-autoimmunity
#9
Amr H Sawalha
Amr H Sawalha is Professor of Internal Medicine and Marvin and Betty Danto Research Professor of Connective Tissue Research at the University of Michigan, Department of Internal Medicine, Division of Rheumatology. He also holds faculty appointments at the Center for Computational Medicine and Bioinformatics and the Graduate Program in Immunology at the University of Michigan. He was recently appointed as Guest Professor at Central South University in Changsha, China. He received his medical degree from Jordan University of Science and Technology and completed his residency training in internal medicine at the University of Oklahoma Health Sciences Center, and his fellowship in rheumatology at the University of Michigan...
March 21, 2017: Epigenomics
https://www.readbyqxmd.com/read/28321377/single-layer-repair-of-large-anterior-skull-base-defects-without-vascularized-mucosal-flap
#10
Frederick Yoo, Marilene B Wang, Marvin Bergsneider, Jeffrey D Suh
Objectives Bilateral anterior skull base (ASB) defects following endoscopic endonasal tumor resection are most commonly repaired utilizing multilayered reconstruction with a vascularized mucosal flap. Single-layer closure of large ASB defects has been described in the literature but this technique has yet to gain a widespread use. We report our experience with a series of patients who underwent reconstruction of large ASB defects using a single-layer intradural graft, without nasoseptal flaps. We also compared the use of acellular dermal matrix (AlloDerm, LifeCell, Branchburg, New Jersey, United States) or collagen matrix xenograft (Duramatrix, Stryker, Kalamazoo, Michigan, United States) as the graft biomaterial...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28318379/prevalence-and-distribution-of-pseudogymnoascus-destructans-in-michigan-bats-submitted-for-rabies-surveillance
#11
Samantha L Darling, Ailam Lim, Julie R Melotti, Daniel J O'Brien, Steven R Bolin
Since 2006, bat populations in North America have suffered devastating mortality from an emerging disease known as white-nose syndrome (WNS). The causal agent of WNS is the fungus Pseudogymnoascus destructans. In April 2014, WNS was discovered in little brown bats ( Myotis lucifugus ) in Michigan, and has since been documented in 12 counties. Because current surveillance for WNS focuses primarily on mine-hibernating species in winter, it is subject geographic, species, and seasonal bias. To investigate species affected and potential associations of gender, seasonal life cycle, and region with P...
March 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28316319/epileptic-spasms-in-paediatric-post-traumatic-epilepsy-at-a-tertiary-referral-centre
#12
Jun T Park, Harry T Chugani
To recognize epileptic spasms (ES) as a seizure type after traumatic brain injury (TBI), accidental or non-accidental, in infants and children. In the process, we aim to gain some insight into the mechanisms of epileptogenesis in ES. A retrospective electronic chart review was performed at the Children's Hospital of Michigan from 2002 to 2012. Electronic charts of 321 patients were reviewed for evidence of post-traumatic epilepsy. Various clinical variables were collected including age at TBI, mechanism of trauma, severity of brain injury, electroencephalography/neuroimaging data, and seizure semiology...
March 17, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28315540/hazardous-drugs-legislative-and-regulatory-efforts-to-improve-safe-handling%C3%A2
#13
AnnMarie L Walton, Seth Eisenberg, Christopher R Friese
Several organizations have safety guidelines regarding handling of hazardous drugs. That said, only Washington and California have enforceable laws that regulate these practices. This article shares the experiences of three states-Washington, Michigan, and North Carolina-in advancing legislative and regulatory efforts. It also offers guidance to nurses seeking to improve the way hazardous drugs are handled and how and where to begin.
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28306757/effect-of-moderate-intensity-exercise-training-on-peak-oxygen-consumption-in-patients-with-hypertrophic-cardiomyopathy-a-randomized-clinical-trial
#14
Sara Saberi, Matthew Wheeler, Jennifer Bragg-Gresham, Whitney Hornsby, Prachi P Agarwal, Anil Attili, Maryann Concannon, Annika M Dries, Yael Shmargad, Heidi Salisbury, Suwen Kumar, Jonathan Herrera, Jonathan Myers, Adam S Helms, Euan A Ashley, Sharlene M Day
Importance: Formulating exercise recommendations for patients with hypertrophic cardiomyopathy is challenging because of concern about triggering ventricular arrhythmias and because a clinical benefit has not been previously established in this population. Objective: To determine whether moderate-intensity exercise training improves exercise capacity in adults with hypertrophic cardiomyopathy. Design, Setting, and Participants: A randomized clinical trial involving 136 patients with hypertrophic cardiomyopathy was conducted between April 2010 and October 2015 at 2 academic medical centers in the United States (University of Michigan Health System and Stanford University Medical Center)...
March 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28306648/site-specific-approach-to-reducing-emergency-department-visits-following-surgery
#15
Hassaan Abdel Khalik, Haley Stevens, Arthur M Carlin, Amanda Stricklen, Rachel Ross, Carl Pesta, Jonathan F Finks, Andrew Ibrahim, Amir A Ghaferi
OBJECTIVE: The aim of this study was to explore the efficacy of current bariatric perioperative measures at reducing emergency department (ED) visits following bariatric surgery in the state of Michigan. SUMMARY OF BACKGROUND DATA: Many ED visits following bariatric surgery do not result in readmission and may be preventable. Little research exists evaluating the efficacy of perioperative measures aimed at reducing ED visits in this population. Therefore, understanding the driving factors behind these preventable ED visits may be a fruitful approach to prevention...
March 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28303632/the-comparative-safety-and-effectiveness-of-bivalirudin-versus-heparin-monotherapy-in-patients-on-dialysis-undergoing-percutaneous-coronary-intervention-insights-from-the-blue-cross-blue-shield-of-michigan-cardiovascular-consortium
#16
Devraj Sukul, Milan Seth, Theodore Schreiber, Akshay Khandelwal, Louis A Cannon, Thomas A LaLonde, Hitinder S Gurm
BACKGROUND: Dialysis patients are at a higher risk of bleeding after percutaneous coronary intervention (PCI); however, due to their exclusion from randomized clinical trials, the optimal antithrombotic regimen for this population remains unknown. We sought to evaluate the comparative safety and effectiveness of bivalirudin monotherapy versus unfractionated heparin (UFH) monotherapy in dialysis patients undergoing PCI. METHODS: We included dialysis patients who underwent PCI in a multicenter registry between January 2010 and September 2015 at 47 Michigan hospitals...
March 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28303312/neutral-evolution-and-dispersal-limitation-produce-biogeographic-patterns-in-microcystis-aeruginosa-populations-of-lake-systems
#17
Sahar Shirani, Ferdi L Hellweger
Molecular observations reveal substantial biogeographic patterns of cyanobacteria within systems of connected lakes. An important question is the relative role of environmental selection and neutral processes in the biogeography of these systems. Here, we quantify the effect of genetic drift and dispersal limitation by simulating individual cyanobacteria cells using an agent-based model (ABM). In the model, cells grow (divide), die, and migrate between lakes. Each cell has a full genome that is subject to neutral mutation (i...
March 16, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28301680/variation-in-the-use-of-advanced-imaging-at-the-time-of-breast-cancer-diagnosis-in-a-statewide-registry
#18
N Lynn Henry, Thomas M Braun, Tara M Breslin, David H Gorski, Samuel M Silver, Jennifer J Griggs
BACKGROUND: Although national guidelines do not recommend extent of disease imaging for patients with newly diagnosed early stage breast cancer given that the harm outweighs the benefits, high rates of testing have been documented. The 2012 Choosing Wisely guidelines specifically addressed this issue. We examined the change over time in imaging use across a statewide collaborative, as well as the reasons for performing imaging and the impact on cost of care. METHODS: Clinicopathologic data and use of advanced imaging tests (positron emission tomography, computed tomography, and bone scan) were abstracted from the medical records of patients treated at 25 participating sites in the Michigan Breast Oncology Quality Initiative (MiBOQI)...
March 16, 2017: Cancer
https://www.readbyqxmd.com/read/28301447/mercury-spill-responses-five-states-2012-2015
#19
Ryan J Wozniak, Anne E Hirsch, Christina R Bush, Stuart Schmitz, Jeff Wenzel
Despite measures to educate the public about the dangers of elemental mercury, spills continue to occur in homes, schools, health care facilities, and other settings, endangering the public's health and requiring costly cleanup. Mercury is most efficiently absorbed by the lungs, and exposure to high levels of mercury vapor after a release can cause cough, sore throat, shortness of breath, nausea, vomiting, diarrhea, headaches, and visual disturbances (1). Children and fetuses are most susceptible to the adverse effects of mercury vapor exposure...
March 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28301397/the-michigan-trauma-quality-improvement-program-results-from-a-collaborative-quality-initiative
#20
Mark R Hemmila, Jill L Jakubus, Anne H Cain-Nielsen, John P Kepros, Wayne E Vander Kolk, Wendy L Wahl, Judy N Mikhail
BACKGROUND: American College of Surgeons verified trauma centers and a third party payer within the state of Michigan built a regional collaborative quality initiative (CQI). The Michigan Trauma Quality Improvement Program began as a pilot in 2008 and expanded to a formal program in 2011. Here, we examine the performance of the collaborative over time with regard to patient outcomes, resource utilization, and process measures. METHODS: Data from the initial 23 hospitals that joined the CQI in 2011 were analyzed...
March 15, 2017: Journal of Trauma and Acute Care Surgery
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