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https://www.readbyqxmd.com/read/29785764/the-effect-of-the-2009-uspstf-breast-cancer-screening-recommendations-on-breast-cancer-in-michigan-a-longitudinal-study
#1
Jamie Caughran, Tom M Braun, Tara M Breslin, Daniel R Smith, Jennifer L Kreinbrink, Grace K Parish, Alan T Davis, Teresa A Bacon-Baguley, Samuel M Silver, Norah L Henry
In 2009, the revised United States Preventive Services Task Force (USPSTF) guidelines recommended against routine screening mammography for women age 40-49 years and against teaching self-breast examinations (SBE). The aim of this study was to analyze whether breast cancer method of presentation changed following the 2009 USPSTF screening recommendations in a large Michigan cohort. Data were collected on women with newly diagnosed stage 0-III breast cancer participating in the Michigan Breast Oncology Quality Initiative (MiBOQI) registry at 25 statewide institutions from 2006 to 2015...
May 21, 2018: Breast Journal
https://www.readbyqxmd.com/read/29780888/empathy-in-internal-medicine-residents-at-community-based-hospitals-a-cross-sectional-study
#2
Jami Foreback, Halina Kusz, Brenda Lovegrove Lepisto, Barbara Pawlaczyk
Introduction: Many research reports revealed declining empathy in medical schools that continues in postgraduate years of training. Objective: The aim of this study is to examine the self-reported empathy levels of internal medicine (IM) residents in 3 community-based teaching hospitals. Methods: The Jefferson Scale of Physician Empathy, Health Professionals version, is an online, self-administered, questionnaire that was offered to 129 current and incoming residents at 1 osteopathic and 2 allopathic, IM training programs in Flint, Michigan...
January 2018: Journal of Medical Education and Curricular Development
https://www.readbyqxmd.com/read/29779563/association-of-polygenic-risk-scores-for-multiple-cancers-in-a-phenome-wide-study-results-from-the-michigan-genomics-initiative
#3
Lars G Fritsche, Stephen B Gruber, Zhenke Wu, Ellen M Schmidt, Matthew Zawistowski, Stephanie E Moser, Victoria M Blanc, Chad M Brummett, Sachin Kheterpal, Gonçalo R Abecasis, Bhramar Mukherjee
Health systems are stewards of patient electronic health record (EHR) data with extraordinarily rich depth and breadth, reflecting thousands of diagnoses and exposures. Measures of genomic variation integrated with EHRs offer a potential strategy to accurately stratify patients for risk profiling and discover new relationships between diagnoses and genomes. The objective of this study was to evaluate whether polygenic risk scores (PRS) for common cancers are associated with multiple phenotypes in a phenome-wide association study (PheWAS) conducted in 28,260 unrelated, genotyped patients of recent European ancestry who consented to participate in the Michigan Genomics Initiative, a longitudinal biorepository effort within Michigan Medicine...
May 17, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29778383/in-vitro-fertilization-interpregnancy-interval-and-risk-of-adverse-perinatal-outcomes
#4
Kristin Palmsten, Michael V Homer, Yujia Zhang, Sara Crawford, Russell S Kirby, Glenn Copeland, Christina D Chambers, Dmitry M Kissin, H Irene Su
OBJECTIVE: To compare associations between interpregnancy intervals (IPIs) and adverse perinatal outcomes in deliveries following IVF with deliveries following spontaneous conception or other (non-IVF) fertility treatments. DESIGN: Cohort using linked birth certificate and assisted reproductive technology surveillance data from Massachusetts and Michigan. SETTING: Not applicable. PATIENT(S): 1,225,718 deliveries. INTERVENTION(S): None...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29776723/outcome-of-a-hand-orthosis-and-hand-therapy-for-carpometacarpal-osteoarthritis-in-daily-practice-a-prospective-cohort-study
#5
Jonathan Tsehaie, Kim R Spekreijse, Robbert M Wouters, Harm P Slijper, Reinier Feitz, Steven E R Hovius, Ruud W Selles
PURPOSE: Initial treatment for symptomatic carpometacarpal (CMC) osteoarthritis (OA) of the thumb is usually nonsurgical. However, evidence on the effect of a hand orthosis and hand therapy for mid- and long-term results is limited, and it is unknown how many patients undergo additional surgical treatment. Therefore, the aim of this study is to describe the outcome of a hand orthosis and hand therapy for CMC OA in a large cohort study, and to evaluate the conversion rate to surgical treatment...
May 15, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29774227/identifying-what-matters-to-hysterectomy-patients-postsurgery-perceptions-beliefs-and-experiences
#6
Andrew S Bossick, Roopina Sangha, Heather Olden, Gwen L Alexander, Ganesa Wegienka
Purpose: Hysterectomy is the most common non-obstetrical surgery for women in the United States. Few investigations comparing hysterectomy surgical approaches include patient-centered outcomes. Methods: The study was performed at Henry Ford Health System in Detroit, Michigan between February 2015 and May 2015. The data were collected through structured focus groups with 24 post-hysterectomy women in order to identify PCOs to employ in a subsequent cohort study of hysterectomy surgical approaches...
2018: Journal of Patient-centered Research and Reviews
https://www.readbyqxmd.com/read/29773942/relationship-between-diabetes-knowledge-glycemic-control-and-associated-health-conditions
#7
Emily Phillips, Rabia Rahman, Mildred Mattfeldt-Beman
Objective: The purpose of this study was to identify any existing relationship between diabetes knowledge and glycemic control, as well as possible associations with patient health, among patients with type 2 diabetes. Design and Methods: This qualitative study used a validated multiple-choice test (the Michigan Diabetes Knowledge Test) to assess diabetes knowledge among 17 hospital patients between the ages of 18 and 75 years with type 2 diabetes and a recent (within 3 months) A1C laboratory value...
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29773923/brain-activity-low-self-control-and-delinquency-an-fmri-study-of-at-risk-adolescents
#8
Ryan Charles Meldrum, Elisa M Trucco, Lora M Cope, Robert A Zucker, Mary M Heitzeg
Purpose: A vast literature finds that low self-control is associated with a myriad of antisocial behaviors. Consequently, increasing attention has focused on the causes of low self-control. While criminologists have directed significant attention to studying its social causes, fewer studies have considered its neural bases. Methods: We add to this nascent body of research by using data collected on an at-risk sample of adolescents participating in the ongoing Michigan Longitudinal Study...
May 2018: Journal of Criminal Justice
https://www.readbyqxmd.com/read/29772799/income-and-self-rated-mental-health-diminished-returns-for-high-income-black-americans
#9
Shervin Assari, Lisa M Lapeyrouse, Harold W Neighbors
Background: The minorities' diminished return theory suggests that socioeconomic position (SEP) generates smaller health gains for racial/ethnic minorities compared to Whites. The current study was a Black⁻White comparison of the association between household income and self-rated mental health (SRMH). Methods: This cross-sectional study used data from the 2017 State of the State Survey (SOSS). With representative sampling, the SOSS generates results that are generalizable to the state of Michigan. This study included 881 adults, ( n = 92) Black and ( n = 782) White...
May 17, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29771175/tamoxifen-citrate-loaded-chitosan-gellan-nanocapsules-for-breast-cancer-therapy-development-characterisation-and-in-vitro-cell-viability-study
#10
Pankaj Kumar Kathle, Nivedita Gautam, Karthikeyan Kesavan
The objective of this study was to evaluate the potential of Chitosan-Gellan nanocapsules (CGNCs) for encapsulation and sustained release of Tamoxifen Citrate (TMC) for breast cancer therapy. Polyelectrolyte complex coacervation method was used for production of CGNCs. Interaction studies were conducted by FT-IR, DSC and XRD to investigate any interaction between drug and excipients. Physicochemical parameters, in vitro drug release and release kinetic were studied. In vitro cell viability study using Michigan Cancer Foundation-7 (MCF-7) breast cancer cells was also investigated...
May 17, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29765820/a-comparative-analysis-of-endoscopic-assisted-transoral-and-transnasal-approaches-to-parapharyngeal-space-a-cadaveric-study
#11
Xicai Sun, Bo Yan, Huy Q Truong, Hamid Borghei-Razavi, Carl H Snyderman, Juan C Fernandez-Miranda
Background  Surgical resection of parapharyngeal space (PPS) tumors is very challenging. An endoscopic-assisted surgical approach to this region requires detailed and precise anatomic knowledge. The main purpose of this study is to describe and compare the detailed anatomy of the PPS via transnasal transpterygoid (TP) and endoscopic-assisted transoral (TO) approaches. Materials and Methods  Six fresh injected cadaver heads (12 sides) were prepared for dissection of the PPS via TP and TO approaches. Computed tomography (CT) with image-based navigation (Navigation System II; Stryker, Kalamazoo, Michigan, United States) was used to identify bony structures around the PPS...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29759012/using-the-replicating-effective-programs-framework-to-adapt-a-heart-health-intervention
#12
Jessica E Ramsay, Mary R Janevic, Cainnear K Hogan, Dominique L Edwards, Cathleen M Connell
Heart disease is the leading cause of death in the United States. African Americans and people of low socioeconomic status suffer disproportionately from heart disease-related morbidity and mortality. In Detroit, Michigan, a primarily African American and low-income urban area, heart disease mortality is at twice the national rate. Despite evidence for the effectiveness of self-management support interventions in reducing chronic disease burden for older adults, few are adapted for communities most in need...
May 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29756240/vitamin-d-intake-and-survival-and-recurrence-in-head-and-neck-cancer-patients
#13
Eva B Yokosawa, Anna E Arthur, Katie M Rentschler, Gregory T Wolf, Laura S Rozek, Alison M Mondul
OBJECTIVES/HYPOTHESIS: With an unacceptably low 5-year survival rate and few identified modifiable factors that affect head and neck cancer (HNC) outcomes, HNC survival remains an important public health problem. Vitamin D has been shown to be associated with immune reactivity and improved outcomes for some cancer sites, but findings are mixed, and few studies have examined vitamin D in relation to HNC. This study aimed to assess the association between vitamin D intake and survival outcomes in HNC patients...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29752205/evaluation-of-the-frequency-of-dispensing-electronically-discontinued-medications-and-associated-outcomes
#14
Erin J Copi, Lindsey R Kelley, Kaleigh K Fisher
OBJECTIVES: To determine if outpatient pharmacies of an academic medical center inadvertently dispense discontinued medications and, if so, if these inadvertently dispensed prescriptions contribute to subsequent hospital admissions and patient harm. METHODS: This was a single-center retrospective chart review. Prescription billing data were analyzed for electronic prescriptions for hypotensives, hypoglycemics, anticoagulants, antiplatelets, and statins picked up from 3 outpatient pharmacies within the health system over a period of 1 year...
May 8, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29752094/photo-ph-controlled-host-guest-interaction-between-an-azobenzene-containing-block-copolymer-and-water-soluble-pillar-6-arene-as-a-strategy-to-construct-the-compound-vesicles-for-controlled-drug-delivery
#15
Junyi Zhou, Haian Xu, Zaizai Tong, Yuhui Yang, Guohua Jiang
Herein, dual stimuli-responsive compound vesicles were constructed based on host-guest interaction between a water-soluble pillar[6]arene (WP6) and an amphiphilic azobenzene-containing block copolymers (BCP). Reversible morphological transformation between compound vesicles and solid aggregates was achieved by repeated pH- and photo-stimuli. These compound vesicles were then applied in the controlled release of water-soluble anticancer drug, doxorubicin hydrochloride (DOX · HCl). Upon external stimuli, the DOX · HCl displayed a faster release rate than that without stimuli...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29750250/analysis-of-fentanyl-and-18-novel-fentanyl-analogs-and-metabolites-by-lc-ms-ms-and-report-of-fatalities-associated-with-methoxyacetylfentanyl-and-cyclopropylfentanyl
#16
Melissa F Fogarty, Donna M Papsun, Barry K Logan
Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported by the Drug Enforcement Administration (DEA) in their third quarter report of 2017 to have been chemically identified seven and five times, respectively, from drug evidence analyzed by the DEA's lab system; Q3 was the first time cyclopropylfentanyl was identified by the DEA's lab system, while methoxyacetylfentanyl was reported one time in Q2 2017...
May 10, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29750055/noncommunicable-disease-and-multimorbidity-in-young-adults-with-cerebral-palsy
#17
Daniel G Whitney, Edward A Hurvitz, Jennifer M Ryan, Maureen J Devlin, Michelle S Caird, Zachary P French, Elie C Ellenberg, Mark D Peterson
Purpose: Individuals with cerebral palsy (CP) are at increased risk for frailty and chronic disease due to factors experienced throughout the lifespan, such as excessive sedentary behaviors and malnutrition. However, little is known about noncommunicable diseases (NCDs) and multimorbidity profiles in young adults with CP. The study objective was to compare NCD and multimorbidity profiles between young adults with and without CP. Methods: A clinic-based sample of adults (18-30 years) with (n=452) and without (n=448) CP was examined at the University of Michigan Medical Center...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29748160/engagement-strategies-for-self-monitoring-symptoms-of-bipolar-disorder-with-mobile-and-wearable-technology-protocol-for-a-randomized-controlled-trial
#18
Amy Cochran, Livia Belman-Wells, Melvin McInnis
BACKGROUND: Monitoring signs and symptoms in bipolar disorder (BP) is typically based on regular assessments from patient-clinician interactions. Mobile and wearable technology promises to make monitoring symptoms in BP easier, but little is known about how best to engage individuals with BP in monitoring symptoms. OBJECTIVE: The objective of this study was to provide the rationale and protocol for a randomized controlled trial that investigates engagement strategies for monitoring symptoms of BP, including the strategies of using activity trackers compared with self-reports and reviewing recorded symptoms weekly with an interviewer...
May 10, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29747583/effect-of-the-wecareadvisor%C3%A2-on-family-caregiver-outcomes-in-dementia-a-pilot-randomized-controlled-trial
#19
Helen C Kales, Laura N Gitlin, Barbara Stanislawski, H Myra Kim, Katherine Marx, Molly Turnwald, Claire Chiang, Constantine G Lyketsos
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are universal and associated with multiple negative outcomes. This pilot randomized controlled trial (RCT) evaluated the effect of using the WeCareAdvisor, an innovative web-based tool developed to enable family caregivers to assess, manage, and track BPSD. METHODS: This RCT enrolled 57 dementia family caregivers from community and clinical settings in Ann Arbor, Michigan and Baltimore, Maryland...
May 10, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29740058/model-based-and-model-free-machine-learning-techniques-for-diagnostic-prediction-and-classification-of-clinical-outcomes-in-parkinson-s-disease
#20
Chao Gao, Hanbo Sun, Tuo Wang, Ming Tang, Nicolaas I Bohnen, Martijn L T M Müller, Talia Herman, Nir Giladi, Alexandr Kalinin, Cathie Spino, William Dauer, Jeffrey M Hausdorff, Ivo D Dinov
In this study, we apply a multidisciplinary approach to investigate falls in PD patients using clinical, demographic and neuroimaging data from two independent initiatives (University of Michigan and Tel Aviv Sourasky Medical Center). Using machine learning techniques, we construct predictive models to discriminate fallers and non-fallers. Through controlled feature selection, we identified the most salient predictors of patient falls including gait speed, Hoehn and Yahr stage, postural instability and gait difficulty-related measurements...
May 8, 2018: Scientific Reports
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