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https://www.readbyqxmd.com/read/28505345/cardio-oncology-a-multidisciplinary-approach-for-detection-prevention-and-management-of-cardiac-dysfunction-in-cancer-patients
#1
Kazuko Tajiri, Kazutaka Aonuma, Ikuo Sekine
Cardiac dysfunction that develops during or after completion of cancer therapy is a growing health concern that should be addressed in a multidisciplinary setting. Cardio-oncology is a new discipline that focuses on screening, monitoring and treating cardiovascular disease during and after cancer treatment. A baseline cardiovascular risk assessment is essential. For high-risk patients, a tailored and detailed plan for cardiovascular management throughout treatment and beyond should also be established. Anthracycline and/or trastuzumab-containing chemotherapy and chest-directed radiation therapy are well known cardiotoxic cancer therapies...
May 15, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28505025/a-rodent-model-of-cardiac-donation-after-circulatory-death-and-novel-biomarkers-of-cardiac-viability-during-ex-vivo-heart-perfusion
#2
Mark J Kearns, Sally Miller, Anson Cheung, Jamil Bashir, Stephanie Wong, Michael A Seidman, John H Boyd
BACKGROUND: Organ donation after circulatory death (DCD) is increasingly being used as a means of addressing the organ supply/demand mismatch in solid organ transplantation. There is reluctance to use DCD hearts, due to an inability to precisely identify hearts that have suffered irreversible injury. We investigated novel biomarkers and clinically relevant endpoints across a spectrum of warm ischemic times (WITs), prior to and during ex vivo heart perfusion (EVHP), to identify features associated with a non-viable cardiac phenotype...
May 13, 2017: Transplantation
https://www.readbyqxmd.com/read/28504630/-global-differences-in-causes-and-diagnostics-of-cardio-metabolic-diseases
#3
Dirk L Christensen, Ib C Bygbjerg, Dan W Meyrowitsch
Cardio-metabolic diseases (CMDs) such as obesity, type 2 diabetes (T2D) and hypertension are now highly prevalent throughout low- and middle-income countries, even though half of the T2D cases cannot be explained by obesity. Non-obese T2D individuals may have been exposed to foetal programming and/or be genetically susceptible to abdominal obesity. There is evidence for ethnic-specific risks for cardiometabolic disease. This calls for expanding research collaboration with so-called South partners in order to qualify decision making on diagnosis and prevention of CMDs at global level...
May 15, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28503768/the-contribution-of-cardio-metabolic-risk-factors-to-estimated-glomerular-filtration-rate-egfr-decline-in-indigenous-australians-with-and-without-albuminuria-the-egfr-follow-up-study
#4
Elizabeth Barr, Federica Barzi, Jaquelyne T Hughes, George Jerums, Kerin O'Dea, Alex Brown, Elif I Ekinci, Graham Rd Jones, Paul D Lawton, Ashim Sinha, Richard J MacIsaac, Alan Cass, Louise J Maple-Brown
BACKGROUND: Risk factors for estimated glomerular filtration rate (eGFR) decline beyond albuminuria are not fully understood in Indigenous Australians who have a 6-fold risk of end-stage kidney disease. We assessed associations between cardio-metabolic risk factors and eGFR decline according to baseline albuminuria status to identify potential treatment targets. METHODS: The eGFR Follow-up study is a longitudinal cohort of 520 Indigenous Australians. Linear mixed regression was used to estimate associations between baseline cardio-metabolic risk factors and annual Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR change (ml/min/1...
May 14, 2017: Nephrology
https://www.readbyqxmd.com/read/28499768/mortality-in-people-with-psychotic-disorders-in-finland-a-population-based-13-year-follow-up-study
#5
Jaakko Keinänen, Outi Mantere, Niina Markkula, Krista Partti, Jonna Perälä, Samuli I Saarni, Tommi Härkänen, Jaana Suvisaari
OBJECTIVES: We conducted a population based study aiming at finding predictors of mortality in psychotic disorders and evaluating the extent to which sociodemographic, lifestyle and health-related factors explain the excess mortality. METHODS: In a nationally representative sample of Finns aged 30-70years (n=5642), psychotic disorders were diagnosed using structured interviews and medical records in 2000-2001. Information on mortality and causes of death was obtained of those who died by the end of year 2013...
May 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28499724/cardio-oncology-in-the-older-adult
#6
REVIEW
Prajwal Reddy, Chetan Shenoy, Anne H Blaes
Heart disease and cancer are the leading causes of death in older adults. Many first-line cancer treatments have the potential for cardiotoxicity. Age-related risk factors, pre-existing cardiac disease, and a high prevalence of comorbidities are reasons for increased cardiotoxicity in older adults. Concerns regarding cardiotoxicity may lead to frailty bias and undertreatment, resulting in suboptimal outcomes. There is an urgent need for geriatric-specific evidence and guidelines to help tailor care for this vulnerable group...
May 9, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28499102/alcohol-consumption-and-mortality-from-coronary-heart-disease-an-updated-meta-analysis-of-cohort-studies
#7
Jinhui Zhao, Tim Stockwell, Audra Roemer, Timothy Naimi, Tanya Chikritzhs
OBJECTIVE: Previous meta-analyses estimate that low-volume alcohol consumption protects against coronary heart disease (CHD). Potential errors in studies include systematic misclassification of drinkers as abstainers, inadequate measurement, and selection bias across the life course. METHOD: Prospective studies of alcohol consumption and CHD mortality were identified in scholarly databases and reference lists. Studies were coded for potential abstainer biases and other study characteristics...
May 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28498904/the-acef-ii-risk-score-for-cardiac-surgery-updated-but-still-parsimonious
#8
Marco Ranucci, Valeria Pistuddi, Sabino Scolletta, Carlo de Vincentiis, Lorenzo Menicanti
Aims: The age, creatinine, and ejection fraction (ACEF) score was introduced in 2009 and is presently included in the guidelines for myocardial revascularization of the European Society of Cardiology and Association for Cardio-Thoracic Surgery as a risk stratification tool for surgical and percutaneous myocardial revascularization. The present study introduces an updated version of the ACEF (ACEF II) inclusive of emergency surgery and pre-operative anaemia. Methods and results: The development series includes 7011 consecutive cardiac surgery patients operated at a single institution...
May 12, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28497385/associations-of-human-skeletal-muscle-fiber-type-and-insulin-sensitivity-blood-lipids-and-vascular-hemodynamics-in-a-cohort-of-premenopausal-women
#9
Gordon Fisher, Samuel T Windham, Perry Griffin, Jonathan L Warren, Barbara A Gower, Gary R Hunter
PURPOSE: Cardiometabolic disease remains a leading cause of morbidity and mortality in developed nations. Consequently, identifying and understanding factors associated with underlying pathophysiological processes leading to chronic cardio metabolic conditions is critical. Metabolic health, arterial elasticity, and insulin sensitivity (SI) may impact disease risk, and may be determined in part by myofiber type. Therefore, the purpose of this study was to test the hypothesis that type I myofiber composition would be associated with high SI, greater arterial elasticity, lower blood pressure, and blood lipids; whereas, type IIx myofibers would be associated with lower SI, lower arterial elasticity, higher blood pressure, blood lipids...
May 11, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28494529/nash-therapy-omega-3-supplementation-vitamin-e-insulin-sensitizers-and-statin-drugs
#10
Stephen Caldwell
Non-alcoholic steatohepatitis (NASH) is the more aggressive form of non-alcoholic fatty liver disease (NAFLD). NASH can progress to hepatic fibrosis, cirrhosis, portal hypertension and primary liver cancer. Therapy is evolving with a substantial number of trials of promising new agents now in progress. In this article however, we will examine data for several older forms of therapy which have been fairly extensively studied over the years: Polyunsaturated Fatty Acid (PUFA) supplements, vitamin E, insulin sensitizing agents with a focus on pioglitazone and statin agents...
May 10, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28489178/blood-pressure-variability-in-the-elderly-association-between-postprandial-and-sleeping-periods
#11
Fernando Abrão Garcia, Beatriz Fidale, Sebastião Rodrigues Ferreira-Filho
Introduction: The variability of arterial blood pressure (BP) is considered an important cardiovascular risk factor. Objective: To verify the possible associations between the postprandial and the sleeping blood pressure variability. Methods: This study evaluated systolic, diastolic, mean, pulse pressures and heart variability in 69 elderly patients in preprandial, postprandial and sleeping periods. One 24 hours ambulatory blood pressure monitoring was used for measurements and the results were showed in the time-rate index...
April 27, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28488901/association-of-shiftwork-and-immune-cells-among-police-officers-from-the-buffalo-cardio-metabolic-occupational-police-stress-study
#12
Michael D Wirth, Michael E Andrew, Cecil M Burchfiel, James B Burch, Desta Fekedulegn, Tara A Hartley, Luenda E Charles, John M Violanti
Shift workers suffer from a constellation of symptoms associated with disruption of circadian rhythms including sleep abnormalities, and abnormal hormone secretion (e.g. melatonin, cortisol). Recent, but limited, evidence suggests that shift workers have elevated levels of circulating white blood cells (WBCs) compared to their day working counterparts. Interestingly, recent reviews highlight the strong linkage between the immune system and circadian rhythms which includes, but is not limited to, circulating cell populations and functions...
May 10, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28486907/effect-of-crocin-on-antibody-titers-to-heat-shock-protein-27-in-subjects-with-metabolic-syndrome
#13
Mina Nosrati, Irandokht Nikbakht-Jam, Saeid Eslami, M Khademi, Mojtaba Foroutan-Tanha, Farzin Hadizadeh, Amir Hosein Sahebkar, Shima Tavallaie, Zhila Taherzadeh, Majid Ghayour-Mobarhan, Gordon A A Ferns
BACKGROUND: Recent studies have shown that antibody titers to heat shock protein 27 (anti-hsp27) and hs-CRP concentrations are elevated in patients with MetS, and may be associated with an increased cardiovascular diseases risk. Crocin is a natural carotenoid with, cardio protective effects. OBJECTIVE: Owing to the previous evidence on the beneficial effects of saffron in patients with MetS, this study investigated the effect of supplementation with crocin, as the active ingredient of saffron, on serum anti-hsp27 and hs-CRP in patients with MetS...
May 9, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28486177/depressive-symptom-profiles-cardio-metabolic-risk-and-inflammation-results-from-the-midus-study
#14
Diana A Chirinos, Kyle W Murdock, Angie S LeRoy, Christopher Fagundes
BACKGROUND: This study aimed to (1) provide a comprehensive characterization of depressive symptoms profiles, and (2) examine the cross-sectional association between depressive symptom profiles and cardio-metabolic outcomes, including metabolic syndrome and obesity, while controlling for sociodemographic variables, health behaviors and inflammation. METHODS: Our sample was comprised of 1085 participants (55.80% female) enrolled in the MIDUS-II biomarker study. Latent profile analysis (LPA) was used to derive depressive symptom profiles using subscales of the Mood and Anxiety Symptom Questionnaire (MASQ) and the Center for Epidemiologic Studies Depression Scale (CES-D) subscales as well as Pittsburgh Sleep Quality Index (PSQI) global score...
April 29, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28484995/management-of-cad-in-patients-with-active-cancer-the-interventional-cardiologists-perspective
#15
REVIEW
Dana Elena Giza, Kostas Marmagkiolis, Elie Mouhayar, Jean-Bernard Durand, Cezar Iliescu
PURPOSE OF REVIEW: Coronary artery disease in patients with active cancer presents particular challenges for clinicians, as optimum management is required in order to treat the underlying malignancy and to reduce morbidity and mortality associated with cardiovascular diseases. Special considerations must be made in respect to either primary or secondary thrombocytopenia, the presence of coagulopathies and the propensity of bleeding, vascular access complications, and increased risk of stent thrombosis...
June 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28481916/tcf21-and-the-environmental-sensor-aryl-hydrocarbon-receptor-cooperate-to-activate-a-pro-inflammatory-gene-expression-program-in-coronary-artery-smooth-muscle-cells
#16
Juyong Brian Kim, Milos Pjanic, Trieu Nguyen, Clint L Miller, Dharini Iyer, Boxiang Liu, Ting Wang, Olga Sazonova, Ivan Carcamo-Orive, Ljubica Perisic Matic, Lars Maegdefessel, Ulf Hedin, Thomas Quertermous
Both environmental factors and genetic loci have been associated with coronary artery disease (CAD), however gene-gene and gene-environment interactions that might identify molecular mechanisms of risk are not easily studied by human genetic approaches. We have previously identified the transcription factor TCF21 as the causal CAD gene at 6q23.2 and characterized its downstream transcriptional network that is enriched for CAD GWAS genes. Here we investigate the hypothesis that TCF21 interacts with a downstream target gene, the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the cellular response to environmental contaminants, including dioxin and polycyclic aromatic hydrocarbons (e...
May 8, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28476705/long-term-results-of-young-patients-with-acute-coronary-syndrome-undergoing-coronary-stent-implantation
#17
Yuan Yao, Yao Zhang
Long-term follow-up studies on young patients with acute coronary syndrome (ACS) undergoing coronary stent implantation are relatively scarce. This study was applied to review the long-term results of young ACS patients who had undergone coronary stenting in our hospital. One hundred and two young patients with ACS underwent coronary stent implantation in our hospital. In this study, inpatient records and long-term data of the 102 patients were comprehensively collected for analysis. Major gender of the young patients was men...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28461624/loss-of-cardio-protective-effects-at-the-adamts7-locus-due-to-gene-smoking-interactions
#18
Danish Saleheen, Wei Zhao, Robin Young, Christopher P Nelson, Weang Kee Ho, Jane F Ferguson, Asif Rasheed, Kristy Ou, Sylvia T Nurnberg, Robert C Bauer, Anuj Goel, Ron Do, Alexandre F R Stewart, Jaana Hartiala, Weihua Zhang, Gudmar Thorleifsson, Rona J Strawbridge, Juha Sinisalo, Stavroula Kanoni, Sanaz Sedaghat, Eirini Marouli, Kati Kristiansson, Jing Hua Zhao, Robert Scott, Dominique Gauguier, Svati H Shah, Albert Vernon Smith, Natalie Van Zuydam, Amanda J Cox, Christina Willenborg, Thorsten Kessler, Lingyao Zeng, Michael A Province, Andrea Ganna, Lars Lind, Nancy L Pedersen, Charles C White, Anni Joensuu, Marcus Edi Kleber, Alistair S Hall, Winfried März, Veikko Salomaa, Christopher O'Donnell, Erik Ingelsson, Mary F Feitosa, Jeanette Erdmann, Donald W Bowden, Colin N A Palmer, Vilmundur Gudnason, Ulf de Faire, Pierre Zalloua, Nicholas Wareham, John R Thompson, Kari Kuulasmaa, George Dedoussis, Markus Perola, Abbas Dehghan, John C Chambers, Jaspal Kooner, Hooman Allayee, Panos Deloukas, Ruth McPherson, Kari Stefansson, Heribert Schunkert, Sekar Kathiresan, Martin Farrall, Philippe M Frossard, Daniel J Rader, Nilesh Samani, Muredach P Reilly
Background -Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-environment interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk. Methods -We analyzed data on 60,919 CHD cases and 80,243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to associate with CHD risk...
May 1, 2017: Circulation
https://www.readbyqxmd.com/read/28459707/hdl-and-the-menopause
#19
Samar R El Khoudary
PURPOSE OF REVIEW: To summarize recent provocative findings on conventional and novel metrics of HDL including HDL-C, HDL subclasses and HDL cholesterol efflux capacity as related to menopause. RECENT FINDINGS: Pattern of menopause-related changes in HDL-C are not consistent, suggesting a complex relationship between HDL and menopause. Growing body of literature indicates that higher levels of HDL-C may not be consistently cardio-protective in midlife women, suggesting a potential change in other metrics of HDL that could not be captured by the static metric HDL-C...
April 28, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28456149/plasma-chemerin-in-young-untrained-men-association-with-cardio-metabolic-traits-and-physical-performance-and-response-to-intensive-interval-training
#20
Nejmeddine Ouerghi, Mohamed Kacem Ben Fradj, Marwa Khammassi, Moncef Feki, Naziha Kaabachi, Anissa Bouassida
OBJECTIVES: Chemerin is an adipose tissue-derived adipokine thought to decrease insulin sensitivity and increase cardiometabolic risk. This study aimed to assess the association of chemerin with cardiometabolic risk and physical performance and examine its response to high-intensity interval training (HIIT). METHODS: Eighteen young men have been applied a HIIT program during 8 weeks. Plasma chemerin together with several cardiometabolic factors and physical performance indices were determined before and after the training program...
February 15, 2017: Neuro Endocrinology Letters
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