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https://www.readbyqxmd.com/read/29599702/age-related-changes-in-neuromodulatory-control-of-bladder-micturition-contractions-originating-in-the-skin
#1
Harumi Hotta, Harue Suzuki, Kaori Iimura, Nobuhiro Watanabe
The brainstem is essential for producing micturition contractions of the urinary bladder. Afferent input from perineal skin evoked by gentle mechanical stimulation inhibits micturition contractions by decreasing both ascending and descending transmissions between the brainstem and spinal cord. Dysfunction of this inhibitory mechanism may be one cause of the increase in the prevalence of overactive bladder in old age. The aim of this study was to examine effect of aging on function of skin afferent fibers that inhibit bladder micturition contractions in rats...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29437815/successful-management-of-benign-paroxysmal-positional-vertigo-bppv-in-a-patient-who-was-ventilated-with-a-c3-complete-spinal-injury-on-a-regional-spinal-unit-intensive-care
#2
Lisa Burrows
Benign paroxysmal positional vertigo (BPPV) occurs in 14.5% of patients with spinal cord injury (SCI) and may require intervention on intensive care unit (ICU). A 61-year-old man was admitted to a spinal injury ICU with a traumatic C3 complete SCI following a mountain bike accident. Ventilated but stable he complained of severe dizziness on rolling, during personal cares, which lasted for 40 s. Clinical examination was limited due to the injury and ventilation. Subjective questioning, visio-ocular control and a modified Dix-Hallpike and roll tests confirmed a right posterior canalithiasis BPPV...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29357488/roller-massage-decreases-spinal-excitability-to-the-soleus
#3
James D Young, Alyssa-Joy Spence, David G Behm
Roller massage (RM) interventions have shown acute increases in range of motion (ROM) and pain pressure threshold (PPT). It is unclear whether the RM-induced increases can be attributed to changes in neural or muscle responses. The purpose of this study was to evaluate the effect of altered afferent input via application of RM on spinal excitability, as measured with the Hoffmann (H-) reflex. A randomized within-subjects design was used. Three 30-s bouts of RM were implemented on a rested, nonexercised, injury-free muscle with 30 s of rest between bouts...
April 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29217331/dosimetric-impact-of-translational-and-rotational-setup-errors-for-spine-stereotactic-body-radiotherapy-a-phantom-study
#4
Makoto Sasaki, Mitsuhiro Nakamura, Nobutaka Mukumoto, Manabu Nakata, Masahiro Hiraoka
This study aimed to investigate experimentally the effect of translational and rotational setup errors on 3-dimensional dose distributions by using the gamma index and dose volumetric indices for spine stereotactic body radiotherapy. Treatment plans were designed in accordance with the Radiation Therapy Oncology Group (RTOG) 0631 protocol. Measurements were taken using a Delta4 phantom (ScandiDos, Uppsala, Sweden). Setup errors were generated using the HexaMotion 6D moving platform (ScandiDos). Dose distributions in the presence of setup errors were evaluated, according to the γ passing rate with the 3% and 2 mm criteria (γ3%/2 mm ) and dose volumetric indices (D90 for the target volume and D2 for the spinal cord), using the Delta4 device (ScandiDos)...
December 4, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29158954/the-relationship-between-segmental-rolling-ability-and-lumbar-multifidus-activation-time
#5
Nicole Clark, Michael L Voight, Ashley M Campbell, Sherry Pierce, Pat Sells, Ryan Cook, Clint Henley, Lindsey Schiller
Background: Segmental rolling has been utilized as an assessment and intervention tool to identify and affect dysfunction of the upper quarter, core, and lower quarter. One theory to explain dysfunctional segmental rolling is a lack of segmental spinal control / stabilization. Faulty muscle firing sequencing has been related to poor spinal stability, however to date, no assessment tool exists to evaluate a patient's motor coordination of local and global musculature. Purpose: The purpose of this study was to assess the temporal sequence of lumbar multifidus activation associated with anterior deltoid activation, and to determine if faulty sequencing was associated with the inability to segmentally roll in subjects without mobility restrictions...
November 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29091557/single-dose-gene-replacement-therapy-for-spinal-muscular-atrophy
#6
Jerry R Mendell, Samiah Al-Zaidy, Richard Shell, W Dave Arnold, Louise R Rodino-Klapac, Thomas W Prior, Linda Lowes, Lindsay Alfano, Katherine Berry, Kathleen Church, John T Kissel, Sukumar Nagendran, James L'Italien, Douglas M Sproule, Courtney Wells, Jessica A Cardenas, Marjet D Heitzer, Allan Kaspar, Sarah Corcoran, Lyndsey Braun, Shibi Likhite, Carlos Miranda, Kathrin Meyer, K D Foust, Arthur H M Burghes, Brian K Kaspar
BACKGROUND: Spinal muscular atrophy type 1 (SMA1) is a progressive, monogenic motor neuron disease with an onset during infancy that results in failure to achieve motor milestones and in death or the need for mechanical ventilation by 2 years of age. We studied functional replacement of the mutated gene encoding survival motor neuron 1 (SMN1) in this disease. METHODS: Fifteen patients with SMA1 received a single dose of intravenous adeno-associated virus serotype 9 carrying SMN complementary DNA encoding the missing SMN protein...
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28577599/molecular-inversion-probes-equipped-with-discontinuous-rolling-cycle-amplification-for-targeting-nucleotide-variants-determining-smn1-and-smn2-genes-in-diagnosis-of-spinal-muscular-atrophy
#7
Hwang-Shang Kou, Chun-Chi Wang
The novel techniques of molecular inversion probes (MIPs) combined with discontinuous rolling cycle amplification (DRCA) was developed for determination of the multi-nucleotide variants at single base. The different-length MIPs, a padlock-probe based technology, are designed to simultaneously recognize the identical nucleotide variants. After ligation and DRCA, the different-length genetic products representing the certain genotypes could be simply determined by the short-end capillary electrophoresis (CE) method...
July 18, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28538340/physical-therapy-for-a-child-with-infantile-idiopathic-scoliosis-and-motor-delay
#8
Rhea K Hall, Mary Jane Rapport
PURPOSE: The purpose of this case report is to describe physical therapy (PT) for a child with infantile idiopathic scoliosis and motor delay. KEY POINTS: A 10-month-old boy with a 28° left thoracolumbar scoliosis was referred for PT and was seen weekly in his home over a 6-month period following a diagnosis of scoliosis and delayed gross motor milestones. Before the initiation of PT, the child was scheduled to undergo serial casting for correction of the spinal curve and was not yet rolling or transitioning in or out of sitting...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28511807/does-the-novel-lateral-trauma-position-cause-more-motion-in-an-unstable-cervical-spine-injury-than-the-logroll-maneuver
#9
RANDOMIZED CONTROLLED TRIAL
Per Kristian Hyldmo, MaryBeth Horodyski, Bryan P Conrad, Sindre Aslaksen, Jo Røislien, Mark Prasarn, Glenn R Rechtine, Eldar Søreide
OBJECTIVE: Prehospital personnel who lack advanced airway management training must rely on basic techniques when transporting unconscious trauma patients. The supine position is associated with a loss of airway patency when compared to lateral recumbent positions. Thus, an inherent conflict exists between securing an open airway using the recovery position and maintaining spinal immobilization in the supine position. The lateral trauma position is a novel technique that aims to combine airway management with spinal precautions...
November 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28442203/patterns-of-health-care-use-of-injured-adults-a-population-based-matched-cohort-study
#10
Rebecca J Mitchell, Cate M Cameron, Rod McClure
BACKGROUND: Healthcare use by traumatically injured individuals prior to and subsequent to their injury are not often explored for different types of injuries. This study aims to describe health care use 12 months preceding and 12 months following a traumatic injury by injury type and injury severity. METHOD: Hospital and mortality data from three Australian states were linked in a population-based matched cohort study. Individuals ≥18 years who had an injury-related hospital admission in 2009 were identified as the injured cohort...
April 14, 2017: Injury
https://www.readbyqxmd.com/read/28215241/sleep-disorders-in-spinal-muscular-atrophy
#11
Maria C Pera, Domenico M Romeo, Alessandra Graziano, Concetta Palermo, Sonia Messina, Giovanni Baranello, Giorgia Coratti, Maria Massaro, Serena Sivo, Maria Teresa Arnoldi, Elena S Mazzone, Laura Antonaci, Leonardo Lapenta, Emilio Albamonte, Lavinia Fanelli, Roberto de Sanctis, Gian Luca Vita, Maria Sframeli, Marika Pane, Eugenio Mercuri
OBJECTIVE: To estimate the frequency of sleep disorders in young persons with type 2 and type 3 spinal muscular atrophy (SMA), and to evaluate the relationship between sleep disorders and different variables such as motor impairment, age, use of ventilation, and use of night orthoses. METHODS: A total of 85 young persons (6-25 years of age) with type 2 and type 3 SMA were assessed using the Sleep Disturbance Scale for Children (SDSC), a scale assessing different sleep factors, and the Hammersmith Functional Motor Scale Expanded (HFMSE), a scale evaluating motor impairment...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28048682/su-f-t-188-a-robust-treatment-planning-technique-for-proton-pencil-beam-scanning-cranial-spinal-irradiation
#12
M Zhu, M Yam, M Mehta, S Badiyan, K Young, R Malyapa, W Regine, K Langen
PURPOSE: To propose a proton pencil beam scanning (PBS) cranial spinal irradiation (CSI) treatment planning technique robust against patient roll, isocenter offset and proton range uncertainty. METHOD: Proton PBS plans were created (Eclipse V11) for three previously treated CSI patients to 36 Gy (1.8 Gy/fractions). The target volume was separated into three regions: brain, upper spine and lower spine. One posterior-anterior (PA) beam was used for each spine region, and two posterior-oblique beams (15° apart from PA direction, denoted as 2PO_15) for the brain region...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048210/su-g-jep1-10-feasibility-of-cyberknife-tracking-using-the-previously-implanted-permanent-brachytherapy-seed-cloud
#13
J Cheung, J Cunha, A Sudhyadhom, C McGuinness, M Roach, M Descovich
PURPOSE: Robotic radiosurgery is a salvage treatment option for patients with recurrent prostate cancer. We explored the feasibility of tracking the bolus of permanent prostate implants (PPI) using image recognition software optimized to track spinal anatomy. METHODS: Forty-five inert iodine seeds were implanted into a gelatin-based prostate phantom. Four superficial gold seeds were inserted to provide ground-truth alignment. A CT scan of the phantom (120 kVp, 1 mm slice thickness) was acquired and a single-energy iterative metal artifact reduction (MAR) algorithm was used to enhance the quality of the DRR used for tracking...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27921118/can-different-occlusal-positions-instantaneously-impact-spine-and-body-posture-a-pilot-study-using-rasterstereography-for-a-three-dimensional-evaluation
#14
Karoline März, Werner Adler, Ragai-Edward Matta, Linda Wolf, Manfred Wichmann, Bastian Bergauer
PURPOSE: Orthodontists influence dental occlusion directly. To suggest any link between dental occlusion and body posture is highly contentious, as evidenced by the literature. Rasterstereography, an optical technique that enables three-dimensional (3D) body measurements to be collected, has not yet been used to impartially examine whether different occlusal positions could instantaneously alter spine and body posture. We therefore set out to use this technique to nonsubjectively evaluate this question under static conditions...
May 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27769560/developmental-milestones-in-type-i-spinal-muscular-atrophy
#15
Roberto De Sanctis, Giorgia Coratti, Amy Pasternak, Jacqueline Montes, Marika Pane, Elena S Mazzone, Sally Dunaway Young, Rachel Salazar, Janet Quigley, Maria C Pera, Laura Antonaci, Leonardo Lapenta, Allan M Glanzman, Danilo Tiziano, Francesco Muntoni, Basil T Darras, Darryl C De Vivo, Richard Finkel, Eugenio Mercuri
The aim of this retrospective multicentric study was to assess developmental milestones longitudinally in type I SMA infants using the Hammersmith Infant Neurological Examination. Thirty-three type I SMA infants, who classically do not achieve the ability to sit unsupported, were included in the study. Our results confirmed that all patients had a score of 0 out of a scale of 4 on items assessing sitting, rolling, crawling, standing or walking. A score of more than 0 was only achieved in three items: head control (n = 13), kicking (n = 15) and hand grasp (n = 18)...
November 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27664403/evaluating-the-functionality-and-usability-of-two-novel-wheelchair-anti-rollback-devices-for-ramp-ascent-in-manual-wheelchair-users-with-spinal-cord-injury
#16
Susan L Deems-Dluhy, Chandrasekaran Jayaraman, Steve Green, Mark V Albert, Arun Jayaraman
BACKGROUND: Difficulty ascending ramps and inclines with a manual wheelchair adversely affects the everyday mobility and overall quality of life of manual wheelchair users. Currently, various anti-rollback devices are available to assist manual wheelchair users to ascend ramps and inclines. However, these devices have 2 main shortcomings: restriction to backward motion limiting recovery from an overturning wheelchair, which is a safety concern; and difficulty in engaging/disengaging the device while on the ramp...
September 21, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27640345/assimilation-of-virtual-legs-and-perception-of-floor-texture-by-complete-paraplegic-patients-receiving-artificial-tactile-feedback
#17
Solaiman Shokur, Simone Gallo, Renan C Moioli, Ana Rita C Donati, Edgard Morya, Hannes Bleuler, Miguel A L Nicolelis
Spinal cord injuries disrupt bidirectional communication between the patient's brain and body. Here, we demonstrate a new approach for reproducing lower limb somatosensory feedback in paraplegics by remapping missing leg/foot tactile sensations onto the skin of patients' forearms. A portable haptic display was tested in eight patients in a setup where the lower limbs were simulated using immersive virtual reality (VR). For six out of eight patients, the haptic display induced the realistic illusion of walking on three different types of floor surfaces: beach sand, a paved street or grass...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27586110/quantitative-evaluation-of-the-occupant-kinematic-response-of-the-thums-50th-percentile-male-model-relative-to-pmhs-laboratory-rollover-tests
#18
David Poulard, Qi Zhang, Jack Ryan Cochran, Bronislaw Gepner, Jason Kerrigan
OBJECTIVE: The objective of the current study was to evaluate the whole-body kinematic response of the Total Human Model for Safety (THUMS) occupant model in controlled laboratory rollover tests by comparing the model response to postmortem human surrogate (PMHS) kinematic response targets published in 2014. METHODS: A computational model of the parametric vehicle buck environment was developed and the AM50 THUMS occupant model (Ver 4.01) was subjected to a pure dynamic roll at 360°/s in trailing-side front-row seating position...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27531116/-the-new-findings-of-high-myopia-by-swept-source-optical-coherence-tomography
#19
REVIEW
Y Y Liu, Q H Han
The fundus disease of high myopia, one of the main reasons leading to visual impairment, includes different types of the retinal, choroidal and scleral changes, and in particular the macular and optic disc lesions. Due to technical limitations, it is relatively difficult to study the characteristics of the sclera and the choroid in humans in vivo. The swept-source optical coherence tomography, with the long wave swept laser as a light source, has less sensitivity roll-off with the tissue depth, which makes it possible to check the choroid and the sclera...
July 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27432028/reliability-and-comparison-of-spinal-end-range-motion-assessment-using-a-skin-surface-device-in-participants-with-and-without-low-back-pain
#20
Jason Zafereo, Sharon Wang-Price, Jace Brown, Evan Carson
OBJECTIVE: The purposes of this study were to determine the reliability of using a skin-surface device to measure global and segmental thoracic and lumbar spine motion in participants with and without low back pain (LBP) and to compare global thoracic and lumbar motion between the 2 groups. METHODS: Forty participants were included in the study (20 adults with LBP and 20 age- and sex-matched adults without LBP). On the same day, 2 raters independently measured thoracic and lumbar spine motion by rolling a skin-surface device along the spine from C7 to S3, with participants at their end range of standing flexion and extension...
July 2016: Journal of Manipulative and Physiological Therapeutics
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