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https://www.readbyqxmd.com/read/28215241/sleep-disorders-in-spinal-muscular-atrophy
#1
Maria C Pera, Domenico M Romeo, Alessandra Graziano, Concetta Palermo, Sonia Messina, Giovanni Baranello, Giorgia Coratti, Maria Massaro, Serena Sivo, Maria Teresa Arnoldi, Elena S Mazzone, Laura Antonaci, Leonardo Lapenta, Emilio Albamonte, Lavinia Fanelli, Roberto de Sanctis, Gian Luca Vita, Maria Sframeli, Marika Pane, Eugenio Mercuri
OBJECTIVE: To estimate the frequency of sleep disorders in young persons with type 2 and type 3 spinal muscular atrophy (SMA), and to evaluate the relationship between sleep disorders and different variables such as motor impairment, age, use of ventilation, and use of night orthoses. METHODS: A total of 85 young persons (6-25 years of age) with type 2 and type 3 SMA were assessed using the Sleep Disturbance Scale for Children (SDSC), a scale assessing different sleep factors, and the Hammersmith Functional Motor Scale Expanded (HFMSE), a scale evaluating motor impairment...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28048682/su-f-t-188-a-robust-treatment-planning-technique-for-proton-pencil-beam-scanning-cranial-spinal-irradiation
#2
M Zhu, M Yam, M Mehta, S Badiyan, K Young, R Malyapa, W Regine, K Langen
PURPOSE: To propose a proton pencil beam scanning (PBS) cranial spinal irradiation (CSI) treatment planning technique robust against patient roll, isocenter offset and proton range uncertainty. METHOD: Proton PBS plans were created (Eclipse V11) for three previously treated CSI patients to 36 Gy (1.8 Gy/fractions). The target volume was separated into three regions: brain, upper spine and lower spine. One posterior-anterior (PA) beam was used for each spine region, and two posterior-oblique beams (15° apart from PA direction, denoted as 2PO_15) for the brain region...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048210/su-g-jep1-10-feasibility-of-cyberknife-tracking-using-the-previously-implanted-permanent-brachytherapy-seed-cloud
#3
J Cheung, J Cunha, A Sudhyadhom, C McGuinness, M Roach, M Descovich
PURPOSE: Robotic radiosurgery is a salvage treatment option for patients with recurrent prostate cancer. We explored the feasibility of tracking the bolus of permanent prostate implants (PPI) using image recognition software optimized to track spinal anatomy. METHODS: Forty-five inert iodine seeds were implanted into a gelatin-based prostate phantom. Four superficial gold seeds were inserted to provide ground-truth alignment. A CT scan of the phantom (120 kVp, 1 mm slice thickness) was acquired and a single-energy iterative metal artifact reduction (MAR) algorithm was used to enhance the quality of the DRR used for tracking...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27921118/can-different-occlusal-positions-instantaneously-impact-spine-and-body-posture-a-pilot-study-using-rasterstereography-for-a-three-dimensional-evaluation
#4
Karoline März, Werner Adler, Ragai-Edward Matta, Linda Wolf, Manfred Wichmann, Bastian Bergauer
PURPOSE: Orthodontists influence dental occlusion directly. To suggest any link between dental occlusion and body posture is highly contentious, as evidenced by the literature. Rasterstereography, an optical technique that enables three-dimensional (3D) body measurements to be collected, has not yet been used to impartially examine whether different occlusal positions could instantaneously alter spine and body posture. We therefore set out to use this technique to nonsubjectively evaluate this question under static conditions...
December 5, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27769560/developmental-milestones-in-type-i-spinal-muscular-atrophy
#5
Roberto De Sanctis, Giorgia Coratti, Amy Pasternak, Jacqueline Montes, Marika Pane, Elena S Mazzone, Sally Dunaway Young, Rachel Salazar, Janet Quigley, Maria C Pera, Laura Antonaci, Leonardo Lapenta, Allan M Glanzman, Danilo Tiziano, Francesco Muntoni, Basil T Darras, Darryl C De Vivo, Richard Finkel, Eugenio Mercuri
The aim of this retrospective multicentric study was to assess developmental milestones longitudinally in type I SMA infants using the Hammersmith Infant Neurological Examination. Thirty-three type I SMA infants, who classically do not achieve the ability to sit unsupported, were included in the study. Our results confirmed that all patients had a score of 0 out of a scale of 4 on items assessing sitting, rolling, crawling, standing or walking. A score of more than 0 was only achieved in three items: head control (n = 13), kicking (n = 15) and hand grasp (n = 18)...
November 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27664403/evaluating-the-functionality-and-usability-of-two-novel-wheelchair-anti-rollback-devices-for-ramp-ascent-in-manual-wheelchair-users-with-spinal-cord-injury
#6
Susan L Deems-Dluhy, Chandrasekaran Jayaraman, Steve Green, Mark V Albert, Arun Jayaraman
BACKGROUND: Difficulty ascending ramps and inclines with a manual wheelchair adversely affects the everyday mobility and overall quality of life of manual wheelchair users. Currently, various anti-rollback devices are available to assist manual wheelchair users to ascend ramps and inclines. However, these devices have 2 main shortcomings: restriction to backward motion limiting recovery from an overturning wheelie, which is a safety concern; and difficulty in engaging/disengaging the device while on the ramp...
September 21, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27640345/assimilation-of-virtual-legs-and-perception-of-floor-texture-by-complete-paraplegic-patients-receiving-artificial-tactile-feedback
#7
Solaiman Shokur, Simone Gallo, Renan C Moioli, Ana Rita C Donati, Edgard Morya, Hannes Bleuler, Miguel A L Nicolelis
Spinal cord injuries disrupt bidirectional communication between the patient's brain and body. Here, we demonstrate a new approach for reproducing lower limb somatosensory feedback in paraplegics by remapping missing leg/foot tactile sensations onto the skin of patients' forearms. A portable haptic display was tested in eight patients in a setup where the lower limbs were simulated using immersive virtual reality (VR). For six out of eight patients, the haptic display induced the realistic illusion of walking on three different types of floor surfaces: beach sand, a paved street or grass...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27586110/quantitative-evaluation-of-the-occupant-kinematic-response-of-the-thums-50th-percentile-male-model-relative-to-pmhs-laboratory-rollover-tests
#8
David Poulard, Qi Zhang, Jack Ryan Cochran, Bronislaw Gepner, Jason Kerrigan
OBJECTIVE: The objective of the current study was to evaluate the whole-body kinematic response of the Total Human Model for Safety (THUMS) occupant model in controlled laboratory rollover tests by comparing the model response to postmortem human surrogate (PMHS) kinematic response targets published in 2014. METHODS: A computational model of the parametric vehicle buck environment was developed and the AM50 THUMS occupant model (Ver 4.01) was subjected to a pure dynamic roll at 360°/s in trailing-side front-row seating position...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27531116/-the-new-findings-of-high-myopia-by-swept-source-optical-coherence-tomography
#9
REVIEW
Y Y Liu, Q H Han
The fundus disease of high myopia, one of the main reasons leading to visual impairment, includes different types of the retinal, choroidal and scleral changes, and in particular the macular and optic disc lesions. Due to technical limitations, it is relatively difficult to study the characteristics of the sclera and the choroid in humans in vivo. The swept-source optical coherence tomography, with the long wave swept laser as a light source, has less sensitivity roll-off with the tissue depth, which makes it possible to check the choroid and the sclera...
July 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27432028/reliability-and-comparison-of-spinal-end-range-motion-assessment-using-a-skin-surface-device-in-participants-with-and-without-low-back-pain
#10
Jason Zafereo, Sharon Wang-Price, Jace Brown, Evan Carson
OBJECTIVE: The purposes of this study were to determine the reliability of using a skin-surface device to measure global and segmental thoracic and lumbar spine motion in participants with and without low back pain (LBP) and to compare global thoracic and lumbar motion between the 2 groups. METHODS: Forty participants were included in the study (20 adults with LBP and 20 age- and sex-matched adults without LBP). On the same day, 2 raters independently measured thoracic and lumbar spine motion by rolling a skin-surface device along the spine from C7 to S3, with participants at their end range of standing flexion and extension...
July 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27171255/a-multisite-quality-improvement-project-to-standardize-the-assessment-of-pressure-ulcer-healing-in-veterans-with-spinal-cord-injuries-disorders
#11
Susan S Thomason, Gail Powell-Cope, Matthew J Peterson, Marylou Guihan, Erik S Wallen, Christine M Olney, Barbara Bates-Jensen
OBJECTIVE: The objective was to implement the evidence-based Spinal Cord Impairment Pressure Ulcer Monitoring Tool (SCI-PUMT) in 23 Spinal Cord Injury/Disorders Centers (SCI/D) in the Veterans Health Administration (VHA). SETTING: A collaborative was held in Minnesota that was attended by key personnel from SCI/D Centers in the VHA. METHODS: This initiative was based on a 3-year longitudinal study that established the validity and reliability of a novel pressure ulcer monitoring tool for persons with spinal cord impairment...
June 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27082602/anterior-reduction-discectomy-and-three-cortical-iliac-bone-grafting-with-instrumentation-to-treat-a-huge-tear-drop-fracture-of-the-axis-a-case-report-and-literature-review
#12
Litai Ma, Yi Yang, Quan Gong, Chen Ding, Hao Liu, Ying Hong
Fractures of the axis body have been little reported and treatment strategies remain controversial and individualized. Not more than 10 cases of huge tear drop fracture of the axis (HTDFA) have been reported in previous studies and the treatment method varies from conservative treatment to an anterior, or posterior, approach surgery. Considering the sparse knowledge of HTDFA, we present a special case report to share our experience and to explore the safety and effectiveness of anterior reduction and fusion to treat HTDFA...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27009158/decreased-otolith-mediated-vestibular-response-in-25-astronauts-induced-by-long-duration-spaceflight
#13
Emma Hallgren, Ludmila Kornilova, Erik Fransen, Dmitrii Glukhikh, Steven T Moore, Gilles Clément, Angelique Van Ombergen, Hamish MacDougall, Ivan Naumov, Floris L Wuyts
The information coming from the vestibular otolith organs is important for the brain when reflexively making appropriate visual and spinal corrections to maintain balance. Symptoms related to failed balance control and navigation are commonly observed in astronauts returning from space. To investigate the effect of microgravity exposure on the otoliths, we studied the otolith-mediated responses elicited by centrifugation in a group of 25 astronauts before and after 6 mo of spaceflight. Ocular counterrolling (OCR) is an otolith-driven reflex that is sensitive to head tilt with regard to gravity and tilts of the gravito-inertial acceleration vector during centrifugation...
June 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/26934672/evaluation-of-five-tests-for-sensitivity-to-functional-deficits-following-cervical-or-thoracic-dorsal-column-transection-in-the-rat
#14
Nitish D Fagoe, Callan L Attwell, Ruben Eggers, Lizz Tuinenbreijer, Dorette Kouwenhoven, Joost Verhaagen, Matthew R J Mason
The dorsal column lesion model of spinal cord injury targets sensory fibres which originate from the dorsal root ganglia and ascend in the dorsal funiculus. It has the advantages that fibres can be specifically traced from the sciatic nerve, verifiably complete lesions can be performed of the labelled fibres, and it can be used to study sprouting in the central nervous system from the conditioning lesion effect. However, functional deficits from this type of lesion are mild, making assessment of experimental treatment-induced functional recovery difficult...
2016: PloS One
https://www.readbyqxmd.com/read/26890423/recovery-times-of-stance-and-gait-balance-control-after-an-acute-unilateral-peripheral-vestibular-deficit
#15
John H J Allum, Flurin Honegger
BACKGROUND: Acute unilateral peripheral vestibular deficit (aUPVD) patients have balance deficits that can improve after several weeks. Determining differences in vestibulo-spinal reflex (VSR) influences on balance control and vestibular ocular reflex (VOR) responses with peripheral recovery and central compensation would provide insights into CNS plasticity mechanisms. Also, clinically, knowing when balance control is approximately normal again should contribute to decisions about working ability after aUPVD...
2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/26700769/cd43-functions-as-an-e-selectin-ligand-for-th17-cells-in-vitro-and-is-required-for-rolling-on-the-vascular-endothelium-and-th17-cell-recruitment-during-inflammation-in-vivo
#16
Francisco Velázquez, Anna Grodecki-Pena, Andrew Knapp, Ane M Salvador, Tania Nevers, Kevin J Croce, Pilar Alcaide
Endothelial E- and P-selectins mediate lymphocyte trafficking in inflammatory processes by interacting with lymphocyte selectin ligands. These are differentially expressed among different T cell subsets and function alone or in cooperation to mediate T cell adhesion. In this study, we characterize the expression and functionality of E-selectin ligands in Th type 17 lymphocytes (Th17 cells) and report that CD43 functions as a Th17 cell E-selectin ligand in vitro that mediates Th17 cell rolling on the vascular endothelium and recruitment in vivo...
February 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26679656/-errors-in-six-degree-of-freedom-pose-estimation-of-spine-tumors-assessed-by-image-guided-radiotherapy
#17
Ping Jiang, Shun Zhou, Jun-jie Wang, Rui-jie Yang, Zi-yi Liu, Shu-kun Jiang, Wei Wang
OBJECTIVE: To evaluate the six-degree setup errors of tumors of cervical vertebra, thoracic vertebra and lumbar vertebra by image guided radiotherapy. METHODS: From May 2013 to June 2014, 30 patients with spinal malignant tumors(10 patients of cervical vertebra, thoracic vertebra and lumbar vertebra respectively) were treated with Elekata Synergy accelerator (Elekta company,Sweden). Six-degree set up errors were corrected using HexaPODTMevoRT bed under image of on board cone beam computed tomography (CBCT) guided...
December 18, 2015: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/26584349/mesenchymal-stem-cells-engineered-to-express-selectin-ligands-and-il-10-exert-enhanced-therapeutic-efficacy-in-murine-experimental-autoimmune-encephalomyelitis
#18
Wenbin Liao, Victor Pham, Linan Liu, Milad Riazifar, Egest J Pone, Shirley Xian Zhang, Fengxia Ma, Mengrou Lu, Craig M Walsh, Weian Zhao
Systemic administration of mesenchymal stem cells (MSCs) affords the potential to ameliorate the symptoms of Multiple Sclerosis (MS) in both preclinical and clinical studies. However, the efficacy of MSC-based therapy for MS likely depends on the number of cells that home to inflamed tissues and on the controlled production of paracrine and immunomodulatory factors. Previously, we reported that engineered MSCs expressing P-selectin glycoprotein ligand-1 (PSGL-1) and Sialyl-Lewis(x) (SLeX) via mRNA transfection facilitated the targeted delivery of anti-inflammatory cytokine interleukin-10 (IL-10) to inflamed ear...
January 2016: Biomaterials
https://www.readbyqxmd.com/read/26580125/comparison-of-intra-abdominal-pressure-among-3-prone-positional-apparatuses-after-changing-from-the-supine-to-the-prone-position-and-applying-positive-end-expiratory-pressure-in-healthy-euvolemic-patients-a-prospective-observational-study
#19
Eugene Kim, Hyun-Chang Kim, Young-Jin Lim, Chi-Heon Kim, Seil Sohn, Chun-Kee Chung, Hyoung-Jun Kim, Hyun Kang, Hee-Pyoung Park
BACKGROUND: Positional apparatuses used for the prone position can affect intra-abdominal pressure (IAP). In this study, we compared the IAP after changing to the prone position and applying various positive end-expiratory pressure (PEEP) levels among 3 prone positional apparatuses. METHODS: A total of 108 healthy euvolemic patients undergoing elective prone spinal surgery were divided into 3 groups based on the positional apparatus used: the Jackson spinal table was used in group J (n=36), the Wilson frame in group W (n=36), and chest rolls in group C (n=36)...
January 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/26535397/controlled-laboratory-comparison-study-of-motion-with-football-equipment-in-a-destabilized-cervical-spine-three-spine-board-transfer-techniques
#20
Mark L Prasarn, MaryBeth Horodyski, Matthew J DiPaola, Christian P DiPaola, Gianluca Del Rossi, Bryan P Conrad, Glenn R Rechtine
BACKGROUND: Numerous studies have shown that there are better alternatives to log rolling patients with unstable spinal injuries, although this method is still commonly used for placing patients onto a spine board. No previous studies have examined transfer maneuvers involving an injured football player with equipment in place onto a spine board. PURPOSE: To test 3 different transfer maneuvers of an injured football player onto a spine board to determine which method most effectively minimizes spinal motion in an injured cervical spine model...
September 2015: Orthopaedic Journal of Sports Medicine
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