Francesca Bagnato, Pascal Sati, Christopher C Hemond, Colm Elliott, Susan A Gauthier, Daniel M Harrison, Caterina Mainero, Jiwon Oh, David Pitt, Russell T Shinohara, Seth A Smith, Bruce Trapp, Christina J Azevedo, Peter A Calabresi, Roland G Henry, Cornelia Laule, Daniel Ontaneda, William D Rooney, Nancy L Sicotte, Daniel S Reich, Martina Absinta
Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis (MS) and have implications for non-relapsing biological progression. In recent years, the discovery of innovative magnetic resonance imaging (MRI) and PET derived biomarkers has made it possible to detect CAL, and to some extent quantify them, in the brain of persons with MS, in vivo. Paramagnetic rim lesions on susceptibility-sensitive MRI sequences, MRI-defined slowly expanding lesions on T1-weighted (T1-w) and T2-w scans, and 18-kDa translocator protein-positive lesions on PET are promising candidate biomarkers of CAL...
January 16, 2024: Brain