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Microglia fractal dimension

Carlos Santos-Filho, Camila M de Lima, César A R Fôro, Marcus A de Oliveira, Nara G M Magalhães, Cristovam Guerreiro-Diniz, Daniel G Diniz, Pedro F da C Vasconcelos, Cristovam W P Diniz
We investigated whether the morphology of microglia in the molecular layer of the dentate gyrus (DG-Mol) or in the lacunosum molecular layer of CA1 (CA1-LMol) was correlated with spatial learning and memory in the capuchin monkey (Cebus apella). Learning and memory was tested in 4 monkeys with visuo-spatial, paired associated learning (PAL) tasks from the Cambridge battery of neuropsychological tests. After testing, monkeys were sacrificed, and hippocampi were sectioned. We specifically immunolabeled microglia with an antibody against the adapter binding, ionized calcium protein...
November 2014: Journal of Chemical Neuroanatomy
Lu Wang, Qian Jiang, Jiang Chu, Li Lin, Xiao-Guang Li, Gao-Shang Chai, Qun Wang, Jian-Zhi Wang, Qing Tian
Accumulation of microtubule-associated protein tau has been observed in the brain of aging and tauopathies. Tau was observed in microglia, but its role is not illustrated. By immunofluorescence staining and the fractal dimension value assay in the present study, we observed that microglia were activated in the brains of rats and mice during aging, simultaneously, the immunoreactivities of total tau and the phosphorylated tau were significantly enhanced in the activated microglia. Furtherly by transient transfection of tau40 (human 2N/4R tau) into the cultured rat microglia, we demonstrated that expression of tau40 increased the level of Iba1, indicating activation of microglia...
2013: PloS One
Z Soltys, O Orzylowska-Sliwinska, M Zaremba, D Orlowski, M Piechota, A Fiedorowicz, K Janeczko, B Oderfeld-Nowak
Pathogenic stimuli induce alterations in the morphology of microglial cells. We analysed changes in lectin-stained cells on the 1st, 3rd, 7th or 14th day after transient global ischemia. Three areas differing in the degree of microglial reaction were selected for analysis: the upper cerebral cortex, the hippocampal CA1 area, and the hilus of the dentate gyrus. Nine morphological parameters, including fractal dimension, lacunarity, self-similarity range, solidity, convexity and form factor were determined. Then the resultant data were processed using principal component analysis (PCA)...
July 15, 2005: Journal of Neuroscience Methods
Dariusz Orłowski, Zbigniew Sołtys, Krzysztof Janeczko
Morphological transformation of lectin-positive microglia/macrophages in the developing rat cerebral hemisphere was analysed using quantitative methods. During the first postnatal month, the cells showed increases in their size and fractal dimension accompanied by a simultaneous decrease in their solidity. Regional variations in dynamics of the process indicated the existence of spatio-temporal developmental gradients within the cerebral hemisphere wall which might correspond with regional patterns of neuronal differentiation...
December 2003: International Journal of Developmental Neuroscience
Z Soltys, M Ziaja, R Pawlínski, Z Setkowicz, K Janeczko
The present study focuses on application of quantitative methods measuring differences between particular morphological types of microglial cells as well as between their proliferating and non-proliferating examples. On the basis of subjective classification, microglial cells of three morphological types (ramified, hypertrophied and bushy) were selected from the neocortex of injured rat brain. Thereafter, the morphological complexity of each cell was assessed by calculation its fractal dimension as well as its form factor, convexity, ramification factor and solidity...
January 1, 2001: Journal of Neuroscience Research
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