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Healthcare predictive modeling

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https://www.readbyqxmd.com/read/28209199/making-life-difficult-for-clostridium-difficile-augmenting-the-pathogen-s-metabolic-model-with-transcriptomic-and-codon-usage-data-for-better-therapeutic-target-characterization
#1
Sara Saheb Kashaf, Claudio Angione, Pietro Lió
BACKGROUND: Clostridium difficile is a bacterium which can infect various animal species, including humans. Infection with this bacterium is a leading healthcare-associated illness. A better understanding of this organism and the relationship between its genotype and phenotype is essential to the search for an effective treatment. Genome-scale metabolic models contain all known biochemical reactions of a microorganism and can be used to investigate this relationship. RESULTS: We present icdf834, an updated metabolic network of C...
February 16, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28196951/understanding-repeated-non-attendance-in-health-services-a-pilot-analysis-of-administrative-data-and-full-study-protocol-for-a-national-retrospective-cohort
#2
Andrea E Williamson, David A Ellis, Philip Wilson, Ross McQueenie, Alex McConnachie
INTRODUCTION: Understanding the causes of low engagement in healthcare is a pre-requisite for improving health services' contribution to tackling health inequalities. Low engagement includes missing healthcare appointments. Serially (having a pattern of) missing general practice (GP) appointments may provide a risk marker for vulnerability and poorer health outcomes. METHODS AND ANALYSIS: A proof of concept pilot using GP appointment data and a focus group with GPs informed the development of missed appointment categories: patients can be classified based on the number of appointments missed each year...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28195877/direct-acting-antivirals-are-effective-for-chronic-hepatitis-c-treatment-in-elderly-patients-a-real-world-study-of-17%C3%A2-487-patients
#3
Feng Su, Lauren A Beste, Pamela K Green, Kristin Berry, George N Ioannou
BACKGROUND: The mean age of patients with chronic hepatitis C virus (HCV) infection in the USA has been increasing. Despite the increasing proportion of HCV-infected elderly patients, this group is under-represented in clinical trials of HCV treatment. AIM: We aimed to describe the real-world effectiveness of direct-acting antivirals (DAAs) among elderly patients. PATIENTS AND METHODS: We retrospectively identified 17 487 HCV-infected patients who were started on treatment with sofosbuvir, ledipasvir/sofosbuvir, or paritaprevir/ombitasvir/ritonavir/dasabuvir-based regimens in the Veterans Affairs Healthcare System between 1 January 2014 and 30 June 2015...
February 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28193655/application-of-fluoroquinolone-resistance-score-in-management-of-complicated-urinary-tract-infections
#4
Ansal Shah, Julie Ann Justo, P Brandon Bookstaver, Joseph Kohn, Helmut Albrecht, Majdi N Al-Hasan
The fluoroquinolone resistance score (FQRS) predicts the probability of fluoroquinolone resistance with good discrimination. The score has been derived in patients with gram-negative bloodstream infections based on fluoroquinolone use within the past 6 months among other clinical and healthcare exposure criteria. This study aims to examine the utility of the FQRS in complicated urinary tract infections (cUTI) and determine whether extension of prior fluoroquinolone use to 12 months improves model discrimination...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28191922/synergistic-integration-of-experimental-and-simulation-approaches-for-the-de-novo-design-of-silk-based-materials
#5
Wenwen Huang, Davoud Ebrahimi, Nina Dinjaski, Anna Tarakanova, Markus J Buehler, Joyce Y Wong, David L Kaplan
Tailored biomaterials with tunable functional properties are crucial for a variety of task-specific applications ranging from healthcare to sustainable, novel bio-nanodevices. To generate polymeric materials with predictive functional outcomes, exploiting designs from nature while morphing them toward non-natural systems offers an important strategy. Silks are Nature's building blocks and are produced by arthropods for a variety of uses that are essential for their survival. Due to the genetic control of encoded protein sequence, mechanical properties, biocompatibility, and biodegradability, silk proteins have been selected as prototype models to emulate for the tunable designs of biomaterial systems...
February 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28188202/progressive-prediction-of-hospitalisation-in-the-emergency-department-uncovering-hidden-patterns-to-improve-patient-flow
#6
Yuval Barak-Corren, Shlomo Hanan Israelit, Ben Y Reis
INTRODUCTION: One of the factors contributing to ED crowding is the lengthy delay in transferring an admitted patient from the ED to an inpatient department (ie, boarding time). An earlier start of the admission process using an automatic hospitalisation prediction model could potentially shorten these delays and reduce crowding. METHODS: Clinical, operational and demographic data were retrospectively collected on 80 880 visits to the ED of Rambam Health Care Campus in Haifa, Israel, from January 2011 to January 2012...
February 10, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28187881/a-clinical-decision-making-mechanism-for-context-aware-and-patient-specific-remote-monitoring-systems-using-the-correlations-of-multiple-vital-signs
#7
Abdur Rahim Mohammad Forkan, Ibrahim Khalil
BACKGROUND AND OBJECTIVES: In home-based context-aware monitoring patient's real-time data of multiple vital signs (e.g. heart rate, blood pressure) are continuously generated from wearable sensors. The changes in such vital parameters are highly correlated. They are also patient-centric and can be either recurrent or can fluctuate. The objective of this study is to develop an intelligent method for personalized monitoring and clinical decision support through early estimation of patient-specific vital sign values, and prediction of anomalies using the interrelation among multiple vital signs...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28187053/factors-associated-with-peer-victimization-among-adolescents-in-taiwan
#8
Hui-Wen Huang, Jyu-Lin Chen, Ruey-Hsia Wang
BACKGROUND: Adolescents who have experienced peer victimization face a higher risk of negative health outcomes. However, little is known about the factors that are associated with peer victimization among adolescents in Taiwan. PURPOSE: The aim of this study was to examine the factors related to peer victimization among Taiwanese adolescents. METHODS: A cross-sectional design was employed. Three hundred seventy-seven adolescents aged 13-16 years from seven middle schools in southern Taiwan were recruited as participants...
February 9, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28186924/can-purchasing-information-be-used-to-predict-adherence-to-cardiovascular-medications-an-analysis-of-linked-retail-pharmacy-and-insurance-claims-data
#9
Alexis A Krumme, Gabriel Sanfélix-Gimeno, Jessica M Franklin, Danielle L Isaman, Mufaddal Mahesri, Olga S Matlin, William H Shrank, Troyen A Brennan, Gregory Brill, Niteesh K Choudhry
OBJECTIVE: The use of retail purchasing data may improve adherence prediction over approaches using healthcare insurance claims alone. DESIGN: Retrospective. SETTING AND PARTICIPANTS: A cohort of patients who received prescription medication benefits through CVS Caremark, used a CVS Pharmacy ExtraCare Health Care (ECHC) loyalty card, and initiated a statin medication in 2011. OUTCOME: We evaluated associations between retail purchasing patterns and optimal adherence to statins in the 12 subsequent months...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28185004/an-18-month-study-of-the-effects-of-ibd-symptomatology-and-emotion-regulation-on-depressed-mood
#10
Inês A Trindade, Cláudia Ferreira, Mariana Moura-Ramos, José Pinto-Gouveia
PURPOSE: Depressive symptomatology in IBD patients is known to predict disease activity, which, in turn, can increase depressive symptoms in perpetuating a cycle between depression and IBD symptomatology. The mechanisms that contribute to the relationship between disease activity and depressive symptoms are not clearly investigated yet. Since emotion regulation has been considered particularly relevant to define the impact of adverse experiences on different outcomes, the current study aimed to examine the longitudinal influence of two maladaptive emotion regulation processes, cognitive fusion and brooding, on the association between disease activity and depressed mood...
February 9, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28169567/using-social-network-analysis-to-better-understand-compulsive-exercise-behavior-among-a-sample-of-sorority-members
#11
Megan S Patterson, Patricia Goodson
BACKGROUND: Compulsive exercise, a form of unhealthy exercise often associated with prioritizing exercise and feeling guilty when exercise is missed, is a common precursor to and symptom of eating disorders. College-aged women are at high risk of exercising compulsively compared to other groups. Social network analysis (SNA) is a theoretical perspective and methodology allowing researchers to observe the effects of relational dynamics on the behaviors of people. METHODS: SNA was used to assess the relationship between compulsive exercise and body dissatisfaction, physical activity, and network variables...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28167743/validation-of-a-risk-stratification-tool-for-fall-related-injury-in-a-state-wide-cohort
#12
Thomas H McCoy, Victor M Castro, Andrew Cagan, Ashlee M Roberson, Roy H Perlis
OBJECTIVE: A major preventable contributor to healthcare costs among older individuals is fall-related injury. We sought to validate a tool to stratify such risk based on readily available clinical data, including projected medication adverse effects, using state-wide medical claims data. DESIGN: Sociodemographic and clinical features were drawn from health claims paid in the state of Massachusetts for individuals aged 35-65 with a hospital admission for a period spanning January-December 2012...
February 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28166673/predictors-of-surgeons-efficiency-in-the-operating-rooms
#13
Yoshinori Nakata, Yuichi Watanabe, Hiroto Narimatsu, Tatsuya Yoshimura, Hiroshi Otake, Tomohiro Sawa
The sustainability of the Japanese healthcare system is questionable because of a huge fiscal debt. One of the solutions is to improve the efficiency of healthcare. The purpose of this study is to determine what factors are predictive of surgeons' efficiency scores. The authors collected data from all the surgical procedures performed at Teikyo University Hospital from April 1 through September 30 in 2013-2015. Output-oriented Charnes-Cooper-Rhodes model of data envelopment analysis was employed to calculate each surgeon's efficiency score...
February 2017: Health Services Management Research
https://www.readbyqxmd.com/read/28152933/panc-support-project-psp-evaluating-the-integration-of-palliative-care-into-a-pancreatic-cancer-program-at-a-comprehensive-cancer-center
#14
Arvind Manohar Shinde, Richard Tuli, Andrew Eugene Hendifar
: 241 Background: Pancreatic adenocarcinoma is the 4th leading cause of cancer death in the US. It is predicted to become the 2nd leading cause by 2030. Advanced disease at diagnosis is common. Fewer than 20% of patients having long-term disease control. Given the high prevalence of physical and psychosocial needs, a quality initiative that embedded a PC physician in a pancreatic cancer program was initiated. METHODS: From June 2015-October 2015, all stage III/IV pancreatic adenocarcinoma patients were referred for palliative consultation...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28149888/scoring-systems-for-the-characterization-of-sepsis-and-associated-outcomes
#15
COMMENT
Natalie McLymont, Guy W Glover
Sepsis is responsible for the utilisation of a significant proportion of healthcare resources and has high mortality rates. Early diagnosis and prompt interventions are associated with better outcomes but is impeded by a lack of diagnostic tools and the heterogeneous and enigmatic nature of sepsis. The recently updated definitions of sepsis have moved away from the centrality of inflammation and the systemic inflammatory response syndrome (SIRS) criteria which have been shown to be non-specific. Sepsis is now defined as a "life-threatening organ dysfunction caused by a dysregulated host response to infection"...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28148537/primary-healthcare-usage-and-use-of-medications-among-immigrant-children-according-to-age-of-arrival-to-norway-a-population-based-study
#16
Lars T Fadnes, Esperanza Diaz
BACKGROUND: Morbidity, use of healthcare and medication use have been reported to vary across groups of migrants and according to the different phases of migration, but little is known about children with immigrant background. In this study, we investigate whether the immigrant children's age of arrival predicts differences in usage of primary healthcare (PHC) and in use of prescribed medication. METHODS: This nationwide, population-based study used information for children under 18 years of age in 2008 from three linked registers in Norway...
February 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28148246/development-of-a-respiratory-severity-score-for-hospitalized-adults-in-a-high-hiv-prevalence-setting-south-africa-2010-2011
#17
Alexander J Millman, Adena Greenbaum, Sibongile Walaza, Adam L Cohen, Michelle J Groome, Carrie Reed, Meredith McMorrow, Stefano Tempia, Marietjie Venter, Florette K Treurnicht, Shabir A Madhi, Cheryl Cohen, Ebrahim Variava
BACKGROUND: Acute lower respiratory tract infections (LRTI) are a frequent cause of hospitalization and mortality in South Africa; however, existing respiratory severity scores may underestimate mortality risk in HIV-infected adults in resource limited settings. A simple predictive clinical score for low-resource settings could aid healthcare providers in the management of patients hospitalized with LRTI. METHODS: We analyzed 1,356 LRTI hospitalizations in adults aged ≥18 years enrolled in Severe Acute Respiratory Illness (SARI) surveillance in three South African hospitals from January 2010 to December 2011...
February 2, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28143517/predictors-of-high-out-of-pocket-healthcare-expenditure-an-analysis-using-bangladesh-household-income-and-expenditure-survey-2010
#18
Azaher Ali Molla, Chunhuei Chi, Alicia Lorena Núñez Mondaca
BACKGROUND: Predictors of high out-of-pocket household healthcare expenditure are essential for creating effective health system finance policy. In Bangladesh, 63.3% of health expenditure is out-of-pocket and born by households. It is imperative to know what determines household health expenditure. This study aims to investigate the predicting factors of high out-of-pocket household healthcare expenditure targeting to put forward policy recommendations on equity in financial burden. METHODS: Bangladesh household income and expenditure survey 2010 provides data for this study...
January 31, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28139949/computational-model-for-timing-of-delivery-in-an-obese-population
#19
Lisa Gill, Michael Holbert
OBJECTIVE: To estimate the impact on stillbirth risk, cesarean deliveries, and delivery-related healthcare cost associated with induction of labor compared to expectant management of term pregnancies in an obese population. METHODS: A decision analysis model was designed to compare the delivery and cost outcomes associated with a hypothetical cohort of 100,000 term pregnancies, complicated by obesity, that were planning a vaginal delivery. The model predicted stillbirths, cesarean deliveries, and total delivery-related healthcare cost from routine induction at 39 weeks compared to expectant management and routine induction each week from 40 to 42 weeks...
January 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28137707/impact-of-functional-somatic-symptoms-on-5-7-year-olds-healthcare-use-and-costs
#20
Troels Græsholt-Knudsen, Anne Mette Skovgaard, Jens Søndergaard Jensen, Charlotte Ulrikka Rask
OBJECTIVE: Knowledge about childhood functional somatic symptoms (FSS) and healthcare costs is scarce. This study aims to assess whether FSS in children aged 5-7 years are associated with increased future primary healthcare. DESIGN: At baseline of the observational cohort study, between years 2005 and 2007, 1327 children from the Copenhagen Child Cohort were assessed at ages 5-7 years for FSS and chronic physical diseases using the Soma Assessment Interview...
January 30, 2017: Archives of Disease in Childhood
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