keyword
MENU ▼
Read by QxMD icon Read
search

Quorum sensing oral bacteria

keyword
https://www.readbyqxmd.com/read/27476444/a-novel-compound-to-maintain-a-healthy-oral-plaque-ecology-in-vitro
#1
Marleen M Janus, Wim Crielaard, Egija Zaura, Bart J Keijser, Bernd W Brandt, Bastiaan P Krom
OBJECTIVE: Dental caries is caused by prolonged episodes of low pH due to acid production by oral biofilms. Bacteria within such biofilms communicate via quorum sensing (QS). QS regulates several phenotypic biofilm parameters, such as biofilm formation and the production of virulence factors. In this study, we evaluated the effect of several QS modifiers on growth and the cariogenic potential of microcosm oral biofilms. METHODS: Biofilms were inoculated with pooled saliva and cultured in the presence of sucrose for 48 and 96 h...
2016: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/27325010/experimental-and-theoretical-investigation-of-multispecies-oral-biofilm-resistance-to-chlorhexidine-treatment
#2
Ya Shen, Jia Zhao, César de la Fuente-Núñez, Zhejun Wang, Robert E W Hancock, Clive R Roberts, Jingzhi Ma, Jun Li, Markus Haapasalo, Qi Wang
We investigate recovery of multispecies oral biofilms following chlorhexidine gluconate (CHX) and CHX with surface modifiers (CHX-Plus) treatment. Specifically, we examine the percentage of viable bacteria in the biofilms following their exposure to CHX and CHX-Plus for 1, 3, and 10 minutes, respectively. Before antimicrobial treatment, the biofilms are allowed to grow for three weeks. We find that (a). CHX-Plus kills bacteria in biofilms more effectively than the regular 2% CHX does, (b). cell continues to be killed for up to one week after exposure to the CHX solutions, (c)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27177290/in-vivo-inhibition-of-porphyromonas-gingivalis-growth-and-prevention-of-periodontitis-with-quorum-sensing-inhibitors
#3
Young-Jae Cho, Hyun Young Song, Heithem Ben Amara, Bong-Kyu Choi, Ryu Eunju, Young-Ah Cho, Yangjo Seol, Yongmoo Lee, Young Ku, In-Chul Rhyu, Ki-Tae Koo
BACKGROUND: Autoinducer (AI)-2 has an important role in biofilm formation in the oral environment. Mature biofilms formed as a result of the cell-to-cell communication make it difficult to overcome periodontitis with the use of antibiotics. Previous in vitro studies suggest that quorum-sensing inhibitors (QSIs) interfere with AI-2. This study compares the QSI effects resulting from an oral inoculation of Porphyromonas gingivalis in an experimental animal model. METHODS: Forty-five male mice were divided into three groups (n = 15 each): 1) infection; 2) QSI; and 3) control...
September 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/26862855/expression-of-the-bitter-receptor-t2r38-in-pancreatic-cancer-localization-in-lipid-droplets-and-activation-by-a-bacteria-derived-quorum-sensing-molecule
#4
Matthias M Gaida, Christine Mayer, Ulrike Dapunt, Sabine Stegmaier, Peter Schirmacher, Guido H Wabnitz, G Maria Hänsch
T2R38 belongs to the family of bitter receptors and was initially detected in cells of the oral cavity. We now describe expression of T2R38 in tumor cells in patients with pancreatic cancer and in tumor-derived cell lines. T2R38 is localized predominantly intracellular in association with lipid droplets, particularly with the lipid droplet membrane. The receptor can be activated by the bona fide ligand for T2R38, phenylthiourea (PTU), and by N-acetyl-dodecanoyl homoserine (AHL-12), a quorum sensing molecule of Pseudomonas aeruginosa, the latter is the only known natural ligand for T2R38...
March 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/26557114/death-and-survival-in-streptococcus-mutans-differing-outcomes-of-a-quorum-sensing-signaling-peptide
#5
REVIEW
Vincent Leung, Delphine Dufour, Céline M Lévesque
Bacteria are considered "social" organisms able to communicate with one another using small hormone-like molecules (pheromones) in a process called quorum-sensing (QS). These signaling molecules increase in concentration as a function of bacterial cell density. For most human pathogens, QS is critical for virulence and biofilm formation, and the opportunity to interfere with bacterial QS could provide a sophisticated means for manipulating the composition of pathogenic biofilms, and possibly eradicating the infection...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26543259/plausible-drug-targets-in-the-streptococcus-mutans-quorum-sensing-pathways-to-combat-dental-biofilms-and-associated-risks
#6
REVIEW
Gurmeet Kaur, Shrinidhi Rajesh, S Adline Princy
Streptococcus mutans, a Gram positive facultative anaerobe, is one among the approximately seven hundred bacterial species to exist in human buccal cavity and cause dental caries. Quorum sensing (QS) is a cell-density dependent communication process that respond to the inter/intra-species signals and elicit responses to show behavioral changes in the bacteria to an aggressive forms. In accordance to this phenomenon, the S. mutans also harbors a Competing Stimulating Peptide (CSP)-mediated quorum sensing, ComCDE (Two-component regulatory system) to regulate several virulence-associated traits that includes the formation of the oral biofilm (dental plaque), genetic competence and acidogenicity...
December 2015: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/26513533/escape-from-the-competence-state-in-streptococcus%C3%A2-mutans-is-governed-by-the-bacterial-population-density
#7
D Dufour, C Villemin, J A Perry, C M Lévesque
Horizontal gene transfer through natural DNA transformation is an important evolutionary mechanism among bacteria. Transformation requires that the bacteria are physiologically competent to take and incorporate free DNA directly from the environment. Although natural genetic transformation is a remarkable feature of many naturally competent bacteria, the process is energetically expensive for the cells. Consequently, a tight control of the competence state is necessary. The objective of the present work was to help decipher the molecular mechanisms regulating the escape from the competence state in Streptococcus mutans, the principal etiological agent responsible for tooth decay in humans...
October 29, 2015: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/26325430/modulation-of-quorum-sensing-controlled-virulence-factors-by-nymphaea-tetragona-water-lily-extract
#8
Md Akil Hossain, Seung-Jin Lee, Ji-Yong Park, Md Ahsanur Reza, Tae-Hwan Kim, Ki-Ja Lee, Joo-Won Suh, Seung-Chun Park
ETHNOPHARMACOLOGICAL RELEVANCE: Nymphaea tetragona is a widely distributed ornamental species with ethnomedicinal uses in the treatment of diarrhea, dysentery, eruptive fevers, and infections. The anti-infectious activities of this herb have already been assessed to clarify its traditional use as a medicine. AIM OF STUDY: In this study, we aimed to verify the inhibitory effects of N. tetragona 50% methanol extract (NTME) on quorum sensing (QS)-controlled virulence factors of bacteria since QS and its virulence factors are novel targets for antimicrobial therapy...
November 4, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25886290/quorum-sensing-dysbiotic-shifts-in-the-hiv-infected-oral-metabiome
#9
Robert E Brown, Mahmoud A Ghannoum, Pranab K Mukherjee, Patrick M Gillevet, Masoumeh Sikaroodi
We implemented a Systems Biology approach using Correlation Difference Probability Network (CDPN) analysis to provide insights into the statistically significant functional differences between HIV-infected patients and uninfected individuals. The analysis correlates bacterial microbiome ("bacteriome"), fungal microbiome ("mycobiome"), and metabolome data to model the underlying biological processes comprising the Human Oral Metabiome. CDPN highlights the taxa-metabolite-taxa differences between the cohorts that frequently capture quorum-sensing modifications that reflect communication disruptions in the dysbiotic HIV cohort...
2015: PloS One
https://www.readbyqxmd.com/read/25645835/sustained-release-of-a-novel-anti-quorum-sensing-agent-against-oral-fungal-biofilms
#10
Mark Feldman, Julia Shenderovich, Abed Al Aziz Al-Quntar, Michael Friedman, Doron Steinberg
Thiazolidinedione-8 (S-8) has recently been identified as a potential anti-quorum-sensing/antibiofilm agent against bacteria and fungi. Based on these results, we investigated the possibility of incorporating S-8 in a sustained-release membrane (SRM) to increase its pharmaceutical potential against Candida albicans biofilm. We demonstrated that SRM containing S-8 inhibits fungal biofilm formation in a time-dependent manner for 72 h, due to prolonged release of S-8. Moreover, the SRM effectively delivered the agent in its active form to locations outside the membrane reservoir...
April 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/25594287/prevention-of-microbial-communities-novel-approaches-based-natural-products
#11
REVIEW
George D Mogosanu, Alexandru M Grumezescu, Keng-Shiang Huang, Ludovic E Bejenaru, Cornelia Bejenaru
Firmly attached to different living or non-living, solid or fluid surfaces rich in nutrients and moisture, microbial biofilm is a matter of great interest due to its major importance for the healthcare community. Depending on common strategies such as mutual protection and hibernation (quiescent bacteria), the resistance, survival and virulence of microbial communities have large implications for human pathology, clinical environment and biomedical devices. The microbial biofilm is continuously changing, stimulating inflammation, increasing vascular permeability and preventing the action of macrophages...
2015: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/25504208/strategies-for-combating-bacterial-biofilm-infections
#12
REVIEW
Hong Wu, Claus Moser, Heng-Zhuang Wang, Niels Høiby, Zhi-Jun Song
Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections...
March 2015: International Journal of Oral Science
https://www.readbyqxmd.com/read/25101248/ai-2-of-aggregatibacter-actinomycetemcomitans-inhibits-candida-albicans-biofilm-formation
#13
Endang W Bachtiar, Boy M Bachtiar, Lucja M Jarosz, Lisa R Amir, Hari Sunarto, Hadas Ganin, Michael M Meijler, Bastiaan P Krom
Aggregatibacter actinomycetemcomitans, a Gram-negative bacterium, and Candida albicans, a polymorphic fungus, are both commensals of the oral cavity but both are opportunistic pathogens that can cause oral diseases. A. actinomycetemcomitans produces a quorum-sensing molecule called autoinducer-2 (AI-2), synthesized by LuxS, that plays an important role in expression of virulence factors, in intra- but also in interspecies communication. The aim of this study was to investigate the role of AI-2 based signaling in the interactions between C...
2014: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/25081571/s-aryl-l-cysteine-sulphoxides-and-related-organosulphur-compounds-alter-oral-biofilm-development-and-ai-2-based-cell-cell-communication
#14
S H Kasper, D Samarian, A P Jadhav, A H Rickard, R A Musah, N C Cady
AIMS: To design and synthesize a library of structurally related, small molecules related to homologues of compounds produced by the plant Petiveria alliacea and determine their ability to interfere with AI-2 cell-cell communication and biofilm formation by oral bacteria. Many human diseases are associated with persistent bacterial biofilms. Oral biofilms (dental plaque) are problematic as they are often associated with tooth decay, periodontal disease and systemic disorders such as heart disease and diabetes...
November 2014: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/25080754/inhibition-of-oral-biofilm-and-cell-cell-communication-using-natural-products-derivatives
#15
(no author information available yet)
No abstract text is available yet for this article.
June 2014: Journal of the California Dental Association
https://www.readbyqxmd.com/read/24854358/unusual-multiple-production-of-n-acylhomoserine-lactones-a-by-burkholderia-sp-strain-c10b-isolated-from-dentine-caries
#16
Share Yuan Goh, Wen-Si Tan, Saad Ahmed Khan, Hooi Pin Chew, Noor Hayaty Abu Kasim, Wai-Fong Yin, Kok-Gan Chan
Bacteria realize the ability to communicate by production of quorum sensing (QS) molecules called autoinducers, which regulate the physiological activities in their ecological niches. The oral cavity could be a potential area for the presence of QS bacteria. In this study, we report the isolation of a QS bacterial isolate C10B from dentine caries. Preliminary screening using Chromobacterium violaceum CV026 biosensor showed that isolate C10B was able to produce N-acylhomoserine lactones (AHLs). This bacterium was further identified as a member of Burkholderia, an opportunistic pathogen...
2014: Sensors
https://www.readbyqxmd.com/read/24487378/candida-and-other-fungal-species-forgotten-players-of-healthy-oral-microbiota
#17
B P Krom, S Kidwai, J M Ten Cate
In the last half-decade or so, interest in the bacterial part of the human microbiome and its role in maintaining health have received considerable attention. Since 2009, over 300 publications have appeared describing the oral bacterial microbiome. Strikingly, fungi in the oral cavity have been studied exclusively in relation to pathologies. However, little to nothing is known about a role of fungi in establishing and maintaining a healthy oral ecology. In a healthy ecology, balance is maintained by the combined positive and negative influences between and among its members...
May 2014: Journal of Dental Research
https://www.readbyqxmd.com/read/24396307/interspecies-communication-and-periodontal-disease
#18
REVIEW
Ajay Mahajan, Baljeet Singh, Divya Kashyap, Amit Kumar, Poonam Mahajan
More than 500 bacterial strains may be found in dental plaque. In the beginning, the emphasis was laid on the isolation of bacteria in pure culture to define their properties. However, now, it has been well established that in nature the bacteria exist as a member of polymicrobial community or consortium of interacting species. Interactions among human oral bacteria are integral to the development and maturation of the plaque. These interactions occur at several levels including physical contact, metabolic exchange, small-signal molecule-mediated communication, and exchange of genetic material...
2013: TheScientificWorldJournal
https://www.readbyqxmd.com/read/24278294/commensal-bacteria-dependent-indole-production-enhances-epithelial-barrier-function-in-the-colon
#19
Yosuke Shimada, Makoto Kinoshita, Kazuo Harada, Masafumi Mizutani, Kazunori Masahata, Hisako Kayama, Kiyoshi Takeda
Microbiota have been shown to have a great influence on functions of intestinal epithelial cells (ECs). The role of indole as a quorum-sensing (QS) molecule mediating intercellular signals in bacteria has been well appreciated. However, it remains unknown whether indole has beneficial effects on maintaining intestinal barriers in vivo. In this study, we analyzed the effect of indole on ECs using a germ free (GF) mouse model. GF mice showed decreased expression of junctional complex molecules in colonic ECs...
2013: PloS One
https://www.readbyqxmd.com/read/24112724/differential-effect-of-autoinducer-2-of-fusobacterium-nucleatum-on-oral-streptococci
#20
Yun-Ji Jang, Jaehyun Sim, Hye-Kyoung Jun, Bong-Kyu Choi
Autoinducer 2 (AI-2) is a quorum sensing molecule and plays an important role in dental biofilm formation, mediating interspecies communication and virulence expression of oral bacteria. Fusobacterium nucleatum connects early colonizing commensals and late colonizing periodontopathogens. F. nucleatum AI-2 and quorum sensing inhibitors (QSIs) can manipulate dental biofilm formation. In this study, we evaluated the effect of F. nucleatum AI-2 and QSIs on biofilm formation of Streptococcus gordonii and Streptococcus oralis, which are initial colonizers in dental biofilm...
November 2013: Archives of Oral Biology
keyword
keyword
37437
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"