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Predictive modeling

J-B Ge, J-T Lin, H-Y Hong, Y-J Sun, Y Li, C-M Zhang
OBJECTIVE: To investigate whether miR-374b can promote the differentiation of MSCs into osteoblasts by mediating PTEN, thus promoting fracture healing. MATERIALS AND METHODS: Primary cultured mouse mesenchymal stem cells were obtained for following experiments. Flow cytometry was used to determine the expression of MSCs surface antigens to identify the purity. Alizarin red staining was used to detect whether MSCs could differentiate into osteoblasts. QRT-PCR was used to detect the expression of osteogenic marker genes as well as miR-374b and PTEN in bone marrow-derived MSCs from fractured mice model...
June 2018: European Review for Medical and Pharmacological Sciences
G Damian Brusko, John Paul G Kolcun, Michael Y Wang
No abstract text is available yet for this article.
July 1, 2018: Neurosurgery
Selene L Fernandez-Valverde, Felipe Aguilera, René Alexander Ramos-Díaz
The advent of high-throughput sequencing technologies has revolutionized the way we understand the transformation of genetic information into morphological traits. Elucidating the network of interactions between genes that govern cell differentiation through development is one of the core challenges in genome research. These networks are known as developmental gene regulatory networks (dGRNs) and consist largely of the functional linkage between developmental control genes, cis-regulatory modules and differentiation genes, which generate spatially and temporally refined patterns of gene expression...
June 18, 2018: Integrative and Comparative Biology
David Mesher, Kavita Panwar, Sara L Thomas, Claire Edmundson, Yoon Hong Choi, Simon Beddows, Kate Soldan
Background: The national human papillomavirus (HPV) immunization program was introduced in England in September 2008 using the bivalent vaccine. Methods: We collected residual vulva-vaginal swab specimens from 16 to 24-year-old women attending for chlamydia screening between 2010 and 2016 and tested for HPV DNA. We compared changes in type-specific (vaccine and nonvaccine) HPV prevalence over time and association with vaccination coverage. For women with known vaccination status, vaccine effectiveness was estimated...
June 18, 2018: Journal of Infectious Diseases
Elin M Svensson, Robin J Svensson, Lindsey H M Te Brake, Martin J Boeree, Norbert Heinrich, Sarah Konsten, Gavin Churchyard, Rodney Dawson, Andreas H Diacon, Gibson S Kibiki, Lilian T Minja, Nyanda E Ntingiya, Ian Sanne, Stephen H Gillespie, Michael Hoelscher, Patrick P J Phillips, Ulrika S H Simonsson, Rob Aarnoutse
Background: Tuberculosis remains a huge public health problem and the prolonged treatment duration obstructs effective tuberculosis control. Higher rifampicin doses have been associated with better bactericidal activity, but optimal dosing is uncertain. This analysis aimed to characterize the relationship between rifampicin plasma exposure and treatment response over 6 months in a recent study investigating the potential for treatment shortening with high-dose rifampicin. Methods: Data were analyzed from 336 patients with pulmonary tuberculosis (97 with pharmacokinetic data) treated with rifampicin doses of 10, 20, or 35 mg/kg...
June 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Laurence S Freedman, Douglas Midthune, Lenore Arab, Ross L Prentice, Amy F Subar, Walter Willett, Marian L Neuhouser, Lesley F Tinker, Victor Kipnis
Improving estimates of individuals' dietary intakes is key to obtaining more reliable evidence for diet-health relationships from nutritional cohort studies. One approach to improvement is combining information from different self-report instruments. Previous work evaluated the gains obtained from combining information from a food frequency questionnaire (FFQ) and multiple 24-hour recalls (24HRs), based on assuming that 24HRs provide unbiased measures of individual intakes. Here, we evaluate the same approach of combining instruments, but based on the better assumption that recovery biomarkers provide unbiased measures of individual intakes...
June 18, 2018: American Journal of Epidemiology
Benjamin Alexander-Dann, Lavinia Lorena Pruteanu, Erin Oerton, Nitin Sharma, Ioana Berindan-Neagoe, Dezső Módos, Andreas Bender
The toxicogenomics field aims to understand and predict toxicity by using 'omics' data in order to study systems-level responses to compound treatments. In recent years there has been a rapid increase in publicly available toxicological and 'omics' data, particularly gene expression data, and a corresponding development of methods for its analysis. In this review, we summarize recent progress relating to the analysis of RNA-Seq and microarray data, review relevant databases, and highlight recent applications of toxicogenomics data for understanding and predicting compound toxicity...
June 19, 2018: Molecular omics
Koosha Ramezani, Iván Marín-Franch, Rongrong Hu, William H Swanson, Lyne Racette
PURPOSE: The purpose of this study was to determine whether combining a structural measure with contrast sensitivity perimetry (CSP), which has lower test-retest variability than static automated perimetry (SAP), reduces prediction error with two models of glaucoma progression. METHODS: In this retrospective analysis, eyes with 5 visits with rim area (RA), SAP and CSP measures were selected from two datasets. Twenty-six eyes with open-angle glaucoma were included in the analyses...
June 18, 2018: Journal of Glaucoma
Liliana Bordeianou, Christy E Cauley, Ruchin Patel, Ronald Bleday, Sadiqa Mahmood, Kevin Kennedy, Khawaja F Ahmed, Deborah Yokoe, David Hooper, Marc Rubin
OBJECTIVE: Create and validate diverticulitis surgical site infection prediction scale. BACKGROUND: Surgical site infections cause significant morbidity after colorectal surgery. An infection prediction scale could target infection prevention bundles to high-risk patients. METHODS: Prospectively collected National Surgical Quality Improvement Program and electronic medical record data obtained on diverticulitis colectomy patients across a Healthcare Network-wide Colorectal Surgery Collaborative (5 hospitals)...
June 18, 2018: Annals of Surgery
Ary Serpa Neto, Luiz Guilherme V da Costa, Sabrine N T Hemmes, Jaume Canet, Göran Hedenstierna, Samir Jaber, Michael Hiesmayr, Markus W Hollmann, Gary H Mills, Marcos F Vidal Melo, Rupert Pearse, Christian Putensen, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz
BACKGROUND: Currently used pre-operative prediction scores for postoperative pulmonary complications (PPCs) use patient data and expected surgery characteristics exclusively. However, intra-operative events are also associated with the development of PPCs. OBJECTIVE: We aimed to develop a new prediction score for PPCs that uses both pre-operative and intra-operative data. DESIGN: This is a secondary analysis of the LAS VEGAS study, a large international, multicentre, prospective study...
June 18, 2018: European Journal of Anaesthesiology
Dan-Qin Sun, Chen-Fei Zheng, Feng-Bin Lu, Sven Van Poucke, Xiao-Ming Chen, Yong-Ping Chen, Lai Zhang, Ming-Hua Zheng
BACKGROUND AND AIM: Serum lactate levels are routinely measured in critically ill patients with cirrhosis, and hyperlactatemia is a common finding, but its prognostic value remains controversial. Our aim was to examine whether serum lactate level could be used as a predictor of outcome in critically ill patients with cirrhosis (CICP) with acute kidney injury (AKI). PATIENTS AND METHODS: In this study, we included 480 consecutive patients with cirrhosis admitted to ICU, complicated with AKI, and were followed up for 365 days...
June 18, 2018: European Journal of Gastroenterology & Hepatology
Alison L Hill
PURPOSE OF REVIEW: To provide a summary of the contributions of mathematical modeling to understanding of HIV persistence during antiretroviral therapy. RECENT FINDINGS: Although HIV persistence during therapy could be caused by continual viral replication or slow-decaying latent infection, most evidence points toward the latter mechanism. The latent reservoir is maintained by a balance of cell death, proliferation, and reactivation, and new methods to estimate the relative contributions of these rates use a wide range of experimental data...
June 16, 2018: Current Opinion in HIV and AIDS
Carolina Vázquez, María Orlova, Paula Scibona, Bruno L Ferreyro, Victoria Otero, Esteban G Jáuregui, Jorge Arbelbide, Waldo H Belloso
: Coumadin oral anticoagulants are widely used in multiple clinical scenarios. Their narrow therapeutic range and a dosing strategy based on 'a posteriori' algorithms, pose them as an interesting group for prediction modelling research. Extensive literature explaining the association between clinical and genetic variables with the dose of warfarin have been published. Limited information exists regarding these factors and acenocoumarol dosing. The aim of the study is to explain through clinical/genetic variables, the weekly dose of acenocoumarol necessary for achieving stable anticoagulation status...
June 18, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Howard J Osofsky, Carl F Weems, Rebecca A Graham, Joy D Osofsky, Tonya C Hansel, Lucy S King
OBJECTIVE: Theorists and researchers have linked resilience with a host of positive psychological and physical health outcomes. This paper examines perceptions of resilience and physical health symptoms in a sample of individuals exposed to multiple community disasters following involvement in integrated mental health services. METHODS: A multiwave naturalistic design was used to follow 762 adult clinic patients (72% female; 28% minority status), ages 18-92 years (mean age=40 years), who were evaluated for resilience and physical health symptoms prior to receiving services and at 1, 3, and 6 months' follow-up...
June 19, 2018: Disaster Medicine and Public Health Preparedness
Suzanne Hoogeveen, Uffe Schjoedt, Michiel van Elk
This study examines the effects of expected transcranial stimulation on the error(-related) negativity (Ne or ERN) and the sense of agency in participants who perform a cognitive control task. Placebo transcranial direct current stimulation was used to elicit expectations of transcranially induced cognitive improvement or impairment. The improvement/impairment manipulation affected both the Ne/ERN and the sense of agency (i.e., whether participants attributed errors to oneself or the brain stimulation device): Expected improvement increased the ERN in response to errors compared with both impairment and control conditions...
June 19, 2018: Journal of Cognitive Neuroscience
Lauren E Marbella, Matthew L Evans, Matthias F Groh, Joseph Nelson, Kent J Griffith, Andrew J Morris, Clare P Grey
Na-ion batteries are promising alternatives to Li-ion systems for electrochemical energy storage because of the higher natural abundance and widespread distribution of Na compared to Li. High capacity anode materials, such as phosphorus, have been explored to realize Na-ion battery technologies that offer comparable performances to their Li-ion counterparts. While P anodes provide unparalleled capacities, the mechanism of sodiation and desodiation is not well-understood, limiting further optimization. Here, we use a combined experimental and theoretical approach to provide molecular-level insight into the (de)sodiation pathways in black P anodes for sodium-ion batteries...
June 19, 2018: Journal of the American Chemical Society
Bo Wang, Mujun Yin, Cheng Cheng, Hongpeng Jiang, Kewei Jiang, Zhanlong Shen, Yingjiang Ye, Shan Wang
Growing evidence indicates a potential role for miR‑490‑3p in tumorigenesis. However, its function in colorectal carcinoma (CRC) remains undefined. In this study, miR‑490‑3p was markedly downregulated in fifty colorectal cancer tissue samples compared with the corresponding adjacent non‑cancerous specimens, by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The expression levels of miR‑490‑3p were closely associated with tumor differentiation and distant metastasis. In addition, both Kaplan-Meier and multivariate analyses indicated CRC patients with elevated miR‑490‑3p amounts had prolonged overall survival...
June 19, 2018: International Journal of Oncology
Sara Dawood, Tushar Kanti Sen, Chi Phan
A practical continuous adsorption study in a packed-bed column was conducted by using two separate layers of kaolin and pine cone based biochar packed bed adsorbents for the removal of methylene blue (MB) dye from its aqueous solution. A series of column experiments were performed to determine the breakthrough curves (BTCs) by varying bed height (3-7 cm), inlet flow rate (13- 17 ml/min) and initial dye concentration (50 -150 mg/L). The Thomas, Yoon-Nelson, Bed Depth Service Time (BDST) and Dose response (DR) dynamic models were applied to column experimental data under various operational conditions to predict the column breakthrough curves (BTC) using both nonlinear regression and linear regression and to determine various characteristic parameters such as percentage removal of dye, breakthrough time, used bed length, mass transfer zone (MTZ) and dye adsorption density q(total) that are useful for process design...
June 19, 2018: Environmental Technology
Gregory I Peterson, Ki-Taek Bang, Tae-Lim Choi
New polyphenylene-based dendronized polymers (denpols), exhibiting extended and rigid conformations, were prepared using ring-opening metathesis polymerization (ROMP). Their mechanochemical degradation was explored in ultrasound-induced elongational flow fields. Degradation rate constants were obtained for polyphenylene-based denpols, of varying generation, across a degree of polymerization (DP) range of ca. 100 to 600. In general, it was found that larger side chains led to increased degradation rates and that the rate enhancement was proportional to the natural log of persistence length (Ln(lp)) or the square root of monomer molecular weight (Mmon0...
June 19, 2018: Journal of the American Chemical Society
Alexander C Jensen, Susan M McHale, Amanda M Pond
Parents compare their children to one another; those comparisons may have implications for the way mothers and fathers treat their children, as well as their children's behavior. Data were collected annually for three years with parents, firstborns, and secondborns from 385 families (Time 1 age: firstborns, 15.71, SD = 1.07, 52% female; secondborns, 13.18, SD = 1.29, 50% female). Parents' beliefs that one child was better behaved predicted differences in siblings' reports of parent-child conflict. Additionally, for siblings close in age, mothers' comparisons at Time 1 predicted youth's problem behavior at Time 3 through siblings' differential conflict with mothers...
June 18, 2018: Journal of Youth and Adolescence
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