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https://www.readbyqxmd.com/read/29684484/characterization-of-long-non-coding-rnas-to-reveal-potential-prognostic-biomarkers-in-hepatocellular-carcinoma
#1
REVIEW
Yijie Ma, Tong Luo, Dong Dong, Xubo Wu, Yilin Wang
Dysregulation of long non-coding RNAs (lncRNAs) plays critical roles in a variety of biological processes. Recent studies have documented that lncRNAs can function as potential biomarkers in cancer prognosis, however, little is known in hepatocellular carcinoma (HCC). To identify lncRNA signatures that have prognostic values in HCC, we analyzed lncRNA expression profiles of 364 HCC patients from The Cancer Genome Atlas (TCGA) dataset. A set of four lncRNAs was identified to be significantly associated with the overall survival...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29684373/racial-disparity-in-utilization-of-high-volume-hospitals-for-surgical-treatment-of-esophageal-cancer
#2
Sadiq S Rehmani, Bian Liu, Adnan Al-Ayoubi, Wissam Raad, Raja M Flores, Faiz Bhora, Emanuela Taioli
BACKGROUND: Utilization of high-volume hospitals (HVH) for esophagectomy has been associated with improved perioperative outcomes and reduced mortality. We aimed to test the hypothesis that black-white racial disparities exist in HVH utilization, and to identify predictors of in-hospital surgical outcomes of esophageal cancer while adjusting for HVH utilization patterns. METHODS: We queried the New York Statewide Planning and Research Cooperative System (SPARCS) database (1995-2012) for esophageal cancer patients who underwent surgical resection exclusively...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29684164/acute-kidney-injury-after-aortic-valve-replacement-in-a-nationally-representative-cohort-in-the-usa
#3
Nilay Kumar, Neetika Garg
Background: Randomized trials have consistently shown lower rates of acute kidney injury (AKI) with transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (SAVR). Comparative rates of AKI for TAVR versus SAVR, and predictors and prognostic implications of AKI after aortic valve replacement (AVR) have not been well studied in nationally representative real-world data. Objectives: First, to compare rates of AKI and dialysis requiring AKI in TAVR versus SAVR...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29679863/discovery-of-new-gyrase-%C3%AE-inhibitors-via-structure-based-modeling
#4
Afaf H Al-Nadaf, Sajeda A Salah, Mutasem O Taha
Gyrase B is an essential enzyme in the prokaryotes which became an attractive target for antibacterial agents. In our study, we implemented a wide range of docking configurations to dock 120 inhibitors into the in the ATP- binding pocket of Gyrase B enzyme (PDB code: 4GEE). LigandFit docking engines and six scoring functions were utilized in the study. Furthermore, the ligands were docked in their ionized and unionized forms into the hydrous and anhydrous binding pocket. We used docking-based Comparative Intermolecular Contacts Analysis (db-CICA) which is a novel methodology to validate and identify the optimal docking configurations...
March 19, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29679317/sensitivity-analysis-for-not-at-random-missing-data-in-trial-based-cost-effectiveness-analysis-a-tutorial
#5
Baptiste Leurent, Manuel Gomes, Rita Faria, Stephen Morris, Richard Grieve, James R Carpenter
Cost-effectiveness analyses (CEA) of randomised controlled trials are a key source of information for health care decision makers. Missing data are, however, a common issue that can seriously undermine their validity. A major concern is that the chance of data being missing may be directly linked to the unobserved value itself [missing not at random (MNAR)]. For example, patients with poorer health may be less likely to complete quality-of-life questionnaires. However, the extent to which this occurs cannot be ascertained from the data at hand...
April 20, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29678984/validating-malignant-melanoma-icd-9-cm-codes-in-umbria-asl-napoli-3-sud-and-friuli-venezia-giulia-administrative-healthcare-databases-a-diagnostic-accuracy-study
#6
Massimiliano Orso, Diego Serraino, Iosief Abraha, Mario Fusco, Gianni Giovannini, Paola Casucci, Francesco Cozzolino, Annalisa Granata, Michele Gobbato, Fabrizio Stracci, Valerio Ciullo, Maria Francesca Vitale, Paolo Eusebi, Walter Orlandi, Alessandro Montedori, Ettore Bidoli
OBJECTIVES: To assess the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes in identifying subjects with melanoma. DESIGN: A diagnostic accuracy study comparing melanoma ICD-9-CM codes (index test) with medical chart (reference standard). Case ascertainment was based on neoplastic lesion of the skin and a histological diagnosis from a primary or metastatic site positive for melanoma. SETTING: Administrative databases from Umbria Region, Azienda Sanitaria Locale (ASL) Napoli 3 Sud (NA) and Friuli Venezia Giulia (FVG) Region...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678172/validity-of-international-classification-of-diseases-icd-coding-for-dengue-infections-in-hospital-discharge-records-in-malaysia
#7
Yuan-Liang Woon, Keng-Yee Lee, Siti Fatimah Zahra Mohd Anuar, Pik-Pin Goh, Teck-Onn Lim
BACKGROUND: Hospitalization due to dengue illness is an important measure of dengue morbidity. However, limited studies are based on administrative database because the validity of the diagnosis codes is unknown. We validated the International Classification of Diseases, 10th revision (ICD) diagnosis coding for dengue infections in the Malaysian Ministry of Health's (MOH) hospital discharge database. METHODS: This validation study involves retrospective review of available hospital discharge records and hand-search medical records for years 2010 and 2013...
April 20, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29678168/self-competence-in-death-work-among-health-and-social-care-workers-a-region-wide-survey-in-hong-kong
#8
Johnny T K Cheung, Doreen W H Au, Wallace C H Chan, Jenny H Y Chan, Kenway Ng, Jean Woo
BACKGROUND: According to the Quality of Death Index, Hong Kong is lagging behind many other Western and Asian countries in the category of palliative and healthcare. To ensure the provision of high-quality palliative care, it is important to explore the self-competence of health and social care workers in coping with death work including palliative care. This region-wide study aims to assess the level of self-competence with a validated Self-Competence in Death Work Scale (SC-DWS) and examine its correlates...
April 20, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29678128/spirpep-an-in-silico-digestion-based-platform-to-assist-bioactive-peptides-discovery-from-a-genome-wide-database
#9
Krittima Anekthanakul, Apiradee Hongsthong, Jittisak Senachak, Marasri Ruengjitchatchawalya
BACKGROUND: Bioactive peptides, including biological sources-derived peptides with different biological activities, are protein fragments that influence the functions or conditions of organisms, in particular humans and animals. Conventional methods of identifying bioactive peptides are time-consuming and costly. To quicken the processes, several bioinformatics tools are recently used to facilitate screening of the potential peptides prior their activity assessment in vitro and/or in vivo...
April 20, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29678022/using-rdf-and-git-to-realize-a-collaborative-metadata-repository
#10
Mark R Stöhr, Raphael W Majeed, Andreas Günther
The German Center for Lung Research (DZL) is a research network with the aim of researching respiratory diseases. The participating study sites' register data differs in terms of software and coding system as well as data field coverage. To perform meaningful consortium-wide queries through one single interface, a uniform conceptual structure is required covering the DZL common data elements. No single existing terminology includes all our concepts. Potential candidates such as LOINC and SNOMED only cover specific subject areas or are not granular enough for our needs...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678005/views-of-health-information-management-staff-on-the-medical-coding-software-in-mashhad-iran
#11
Khalil Kimiafar, Fatemeh Hemmati, Alireza Banaye Yazdipour, Masoumeh Sarbaz
Systematic evaluation of Health Information Technology (HIT) and users' views leads to the modification and development of these technologies in accordance with their needs. The purpose of this study was to investigate the views of Health Information Management (HIM) staff on the quality of medical coding software. A descriptive cross-sectional study was conducted between May to July 2016 in 26 hospitals (academic and non-academic) in Mashhad, north-eastern Iran. The study population consisted of the chairs of HIM departments and medical coders (58 staff)...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677213/ifn-%C3%AE-and-micrornas-are-important-modulators-of-the-pulmonary-innate-immune-response-against-influenza-a-h1n2-infection-in-pigs
#12
Louise Brogaard, Lars E Larsen, Peter M H Heegaard, Christian Anthon, Jan Gorodkin, Ralf Dürrwald, Kerstin Skovgaard
The innate immune system is paramount in the response to and clearance of influenza A virus (IAV) infection in non-immune individuals. Known factors include type I and III interferons and antiviral pathogen recognition receptors, and the cascades of antiviral and pro- and anti-inflammatory gene expression they induce. MicroRNAs (miRNAs) are increasingly recognized to participate in post-transcriptional modulation of these responses, but the temporal dynamics of how these players of the antiviral innate immune response collaborate to combat infection remain poorly characterized...
2018: PloS One
https://www.readbyqxmd.com/read/29677065/development-and-validation-of-an-algorithm-to-classify-as-equivalent-the-procedures-in-icd-10-pcs-that-differ-only-by-laterality
#13
Richard H Epstein, Franklin Dexter, Liam O'Neill
BACKGROUND: The switch from International Classification of Diseases, Ninth Revision, Clinical Modification to International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) for coding of inpatient procedures in the United States increased the number of procedural codes more than 19-fold, in large part due to the addition of laterality. We examined ICD-10-PCS codes for pairs of mirror-image procedures that are surgically equivalent. METHODS: We developed an algorithm in structured query language (SQL) to identify ICD-10-PCS codes differing only by laterality...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29676203/-5p-and-3p-strands-of-mir-145-and-mir-140-during-mesenchymal-stem-cell-chondrogenic-differentiation
#14
Jonathan D Kenyon, Olga Sergeeva, Rodrigo A Somoza, Ming Li, Arnold I Caplan, Ahmad M Khalil, Zhenghong Lee
The chondrogenic differentiation of mesenchymal stem cells (MSCs) is mediated by transcription factors and small non-coding RNAs such as micro-RNAs (miRNAs). Each miRNA is initially transcribed as a long transcript, which matures to produce -5p and -3p strands. It is widely believed that the mature and functional miRNA from any given pre-miRNA, usually the -5p strand, is functional, while the opposing -3p strand is degraded. However, recent cartilage literature started to show functional -3p stands for a few miRNAs...
April 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29673571/the-effect-of-hospital-acuity-on-severe-maternal-morbidity-in-high-risk-patients
#15
Mark A Clapp, Kaitlyn E James, Anjali J Kaimal
BACKGROUND: In 2015, the Society for Maternal-Fetal Medicine and the American College of Obstetricians and Gynecologists published guidelines that established levels of maternal care. These guidelines outline the nursing, provider, and facility requirements for hospitals to be designated a birthing center or one of four levels of care. To-date, these levels of maternal care have not been widely adopted, and currently, no data exists on how these designations may affect maternal or neonatal outcomes...
April 16, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29672914/revisiting-the-nih-taskforce-on-the-research-needs-of-eosinophil-associated-diseases-re-tread
#16
REVIEW
Paneez Khoury, Praveen Akuthota, Steven J Ackerman, Joseph R Arron, Bruce S Bochner, Margaret H Collins, Jean-Emmanuel Kahn, Patricia C Fulkerson, Gerald J Gleich, Rashmi Gopal-Srivastava, Elizabeth A Jacobsen, Kristen M Leiferman, Levi-Schaffer Francesca, Sameer K Mathur, Michael Minnicozzi, Calman Prussin, Marc E Rothenberg, Florence Roufosse, Kathleen Sable, Dagmar Simon, Hans-Uwe Simon, Lisa A Spencer, Jonathan Steinfeld, Andrew J Wardlaw, Michael E Wechsler, Peter F Weller, Amy D Klion
BACKGROUND: Eosinophil-associated diseases (EADs) are rare, heterogeneous disorders characterized by the presence of eosinophils in tissues and/or peripheral blood resulting in immunopathology. The heterogeneity of tissue involvement, lack of sufficient animal models, technical challenges in working with eosinophils, and lack of standardized histopathologic approaches have hampered progress in basic research. Additionally, clinical trials and drug development for rare EADs are limited by the lack of primary and surrogate endpoints, biomarkers, and validated patient-reported outcomes...
April 19, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29671891/the-association-of-circulating-inflammation-proteins-and-gallstone-disease
#17
Zhiwei Liu, Troy J Kemp, Yu-Tang Gao, Amanda Corbel, Emma E McGee, Bingsheng Wang, Ming-Chang Shen, Asif Rashid, Ann W Hsing, Allan Hildesheim, Ruth M Pfeiffer, Ligia A Pinto, Jill Koshiol
BACKGROUND: Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones. METHODS: We measured 13 cytokines (including 10 interleukins), that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. We estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders...
April 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29671405/ncrna-disease-association-prediction-based-on-sequence-information-and-tripartite-network
#18
Takuya Mori, Hayliang Ngouv, Morihiro Hayashida, Tatsuya Akutsu, Jose C Nacher
BACKGROUND: Current technology has demonstrated that mutation and deregulation of non-coding RNAs (ncRNAs) are associated with diverse human diseases and important biological processes. Therefore, developing a novel computational method for predicting potential ncRNA-disease associations could benefit pathologists in understanding the correlation between ncRNAs and disease diagnosis, treatment, and prevention. However, only a few studies have investigated these associations in pathogenesis...
April 11, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29671197/distinct-response-to-gdf15-knockdown-in-pediatric-and-adult-glioblastoma-cell-lines
#19
Mirella Baroni, Suely Kazue Nagahashi Marie, Paola Fernanda Fedatto, Augusto Faria Andrade, Veridiana Kill Suazo, Gustavo Alencastro Veiga Cruzeiro, Rosane de Paula Queiroz, Luiz Gonzaga Tone, Carlos Alberto Scrideli
INTRODUCTION: Glioblastoma (GBM) is the most common malignant primary brain tumor affecting adults. In pediatric patients, GBM exhibits genetic variations distinct from those identified in the adult GBM phenotype. This tumor exhibits complex genetic changes leading to malignant progression and resistance to standard therapies including radiotherapy and temozolomide treatment. The GDF15 gene codes for a growth factor whose expression is altered in the presence of inflammations and malignancies...
April 18, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29670621/integrated-analysis-reveals-that-mir-193b-mir-671-and-trem-1-correlate-with-a-good-response-to-treatment-of-human-localized-cutaneous-leishmaniasis-caused-by-leishmania-braziliensis
#20
Sara Nunes, Icaro Bonyek Silva, Mariana Rosa Ampuero, Almério Libório Lopes de Noronha, Lígia Correia Lima de Souza, Thaizza Cavalcante Correia, Ricardo Khouri, Viviane Sampaio Boaventura, Aldina Barral, Pablo Ivan Pereira Ramos, Cláudia Brodskyn, Pablo Rafael Silveira Oliveira, Natalia Machado Tavares
Localized cutaneous leishmaniasis (LCL) is a chronic disease characterized by ulcerated skin lesion(s) and uncontrolled inflammation. The mechanisms underlying the pathogenesis of LCL are not completely understood, and little is known about posttranscriptional regulation during LCL. MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and can be implicated in the pathogenesis of LCL. We investigated the involvement of miRNAs and their targets genes in human LCL using publicly available transcriptome data sets followed by ex vivo validation...
2018: Frontiers in Immunology
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