keyword
MENU ▼
Read by QxMD icon Read
search

Code validation

keyword
https://www.readbyqxmd.com/read/29913370/consistent-criticality-and-radiation-studies-of-swiss-spent-nuclear-fuel-the-cs-2-m-approach
#1
D Rochman, A Vasiliev, H Ferroukhi, M Pecchia
In this paper, a new method is proposed to systematically calculate at the same time canister loading curves and radiation sources, based on the inventory information from an in-core fuel management system. As a demonstration, the isotopic contents of the assemblies come from a Swiss PWR, considering more than 6000 cases from 34 reactor cycles. The CS2 M approach consists in combining four codes: CASMO and SIMULATE to extract the assembly characteristics (based on validated models), the SNF code for source emission and MCNP for criticality calculations for specific canister loadings...
June 15, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29913021/implementation-of-a-clinical-prediction-model-using-daily-postnatal-weight-gain-birth-weight-and-gestational-age-to-risk-stratify-rop
#2
Kortany McCauley, Anupama Chundu, Helen Song, Robin High, Donny Suh
PURPOSE: To develop a simple prognostic model using postnatal weight gain, birth weight, and gestational age to identify infants at risk for developing severe retinopathy of prematurity (ROP). METHODS: Medical records from two tertiary referral centers with the diagnosis code "Retinopathy of Prematurity" were evaluated. Those with a birth weight of 1,500 g or less, gestational age of 30 weeks or younger, and unstable clinical courses were included. Multivariate regression analysis was applied to transform three independent variables into a growth rate algorithm...
June 18, 2018: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29911922/positive-association-between-hypertension-and-urinary-bladder-cancer-epidemiologic-evidence-involving-79-236-propensity-score-matched-individuals
#3
Victor C Kok, Han-Wei Zhang, Chin-Teng Lin, Shih-Chung Huang, Ming-Feng Wu
INTRODUCTION: We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer. MATERIAL AND METHODS: We performed a population-based cohort study on adults using a National Health Insurance Research Database (NHIRD) dataset. Hypertension and comparison non-hypertensive (COMP) groups comprising 39,618 patients each were propensity score-matched by age, sex, index date, and medical comorbidities. The outcome was incident UB cancer validated using procedure codes...
June 18, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29910990/expressional-and-functional-interactions-of-two-apis-cerana-cerana-olfactory-receptors
#4
Lina Guo, Huiting Zhao, Yusuo Jiang
Apis cerana cerana relies on its sensitive olfactory system to perform foraging activities in the surrounding environment. Olfactory receptors (ORs) are a primary requirement for odorant recognition and coding. However, the molecular recognition of volatile compounds with ORs in A. cerana cerana is still not clear. Hence, in the present study, we achieved transient transfection and cell surface expression of A. cerana cerana ORs (AcerOr1 and AcerOr2; AcerOr2 is orthologous to the co-receptor) in Spodoptera frugiperda (Sf9) cells...
2018: PeerJ
https://www.readbyqxmd.com/read/29909114/predicting-survival-from-large-echocardiography-and-electronic-health-record-datasets-optimization-with-machine-learning
#5
Manar D Samad, Alvaro Ulloa, Gregory J Wehner, Linyuan Jing, Dustin Hartzel, Christopher W Good, Brent A Williams, Christopher M Haggerty, Brandon K Fornwalt
OBJECTIVES: The goal of this study was to use machine learning to more accurately predict survival after echocardiography. BACKGROUND: Predicting patient outcomes (e.g., survival) following echocardiography is primarily based on ejection fraction (EF) and comorbidities. However, there may be significant predictive information within additional echocardiography-derived measurements combined with clinical electronic health record data. METHODS: Mortality was studied in 171,510 unselected patients who underwent 331,317 echocardiograms in a large regional health system...
June 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29907560/validation-of-a-natural-language-processing-algorithm-for-detecting-infectious-disease-symptoms-in-primary-care-electronic-medical-records-in-singapore
#6
Antony Hardjojo, Arunan Gunachandran, Long Pang, Mohammed Ridzwan Bin Abdullah, Win Wah, Joash Wen Chen Chong, Ee Hui Goh, Sok Huang Teo, Gilbert Lim, Mong Li Lee, Wynne Hsu, Vernon Lee, Mark I-Cheng Chen, Franco Wong, Jonathan Siung King Phang
BACKGROUND: Free-text clinical records provide a source of information that complements traditional disease surveillance. To electronically harness these records, they need to be transformed into codified fields by natural language processing algorithms. OBJECTIVE: The aim of this study was to develop, train, and validate Clinical History Extractor for Syndromic Surveillance (CHESS), an natural language processing algorithm to extract clinical information from free-text primary care records...
June 11, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29906293/tellurium-notebooks-an-environment-for-reproducible-dynamical-modeling-in-systems-biology
#7
J Kyle Medley, Kiri Choi, Matthias König, Lucian Smith, Stanley Gu, Joseph Hellerstein, Stuart C Sealfon, Herbert M Sauro
The considerable difficulty encountered in reproducing the results of published dynamical models limits validation, exploration and reuse of this increasingly large biomedical research resource. To address this problem, we have developed Tellurium Notebook, a software system for model authoring, simulation, and teaching that facilitates building reproducible dynamical models and reusing models by 1) providing a notebook environment which allows models, Python code, and narrative to be intermixed, 2) supporting the COMBINE archive format during model development for capturing model information in an exchangeable format and 3) enabling users to easily simulate and edit public COMBINE-compliant models from public repositories to facilitate studying model dynamics, variants and test cases...
June 15, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29904728/transcriptomic-profiling-of-human-skin-biopsies-in-the-clinical-trial-setting-a-protocol-for-high-quality-rna-extraction-from-skin-tumours
#8
Marina Danilenko, Robert Stones, Neil Rajan
Transcriptomic profiling of skin disease using next generation sequencing allows for detailed information on aspects of RNA biology including gene expression, non-coding regulatory elements and gene splicing. The application of RNA sequencing to human skin disease and cancer is often hampered by degraded RNA. Here we describe a protocol that allows for consistently intact RNA to be extracted from snap frozen skin biopsy samples, which has been validated in a clinical trial setting. Human skin tumour punch biopsies (n=28) ranging from 4-6mm in diameter were obtained from 14 patients with an inherited skin tumour syndrome (CYLD cutaneous syndrome) and frozen in liquid nitrogen prior to being stored at -80°C...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29903696/types-and-frequency-of-infusion-pump-alarms-protocol-for-a-retrospective-data-analysis
#9
Kevin R Glover, Rachel R Vitoux, Catherine Schuster, Christopher R Curtin
BACKGROUND: The variety of alarms from all types of medical devices has increased from 6 to 40 in the last three decades, with today's most critically ill patients experiencing as many as 45 alarms per hour. Alarm fatigue has been identified as a critical safety issue for clinical staff that can lead to potentially dangerous delays or nonresponse to actionable alarms, resulting in serious patient injury and death. To date, most research on medical device alarms has focused on the nonactionable alarms of physiological monitoring devices...
June 14, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29903409/validation-of-data-from-electronic-data-warehouse-in-diabetic-ketoacidosis-caution-is-needed
#10
Jennifer VanderWeele, Teresa Pollack, Diana Johnson Oakes, Colleen Smyrniotis, Vidhya Illuri, Priyathama Vellanki, Kevin O'Leary, Jane Holl, Grazia Aleppo, Mark E Molitch, Amisha Wallia
AIMS: This study validated enterprise data warehouse (EDW) data for a cohort of hospitalized patients with a primary diagnosis of diabetic ketoacidosis (DKA). METHODS: 247 patients with 319 admissions for DKA (ICD-9 code 250.12, 250.13, or 250.xx with biochemical criteria for DKA) were admitted to Northwestern Memorial Hospital from 1/1/2010 to 9/1/2013. Validation was performed by electronic medical record (EMR) review of 10% of admissions (N = 32). Classification of diabetes type (Type 1 vs...
May 8, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29902694/challenges-of-evaluating-chronic-heart-failure-and-acute-heart-failure-events-in-research-studies-using-large-health-care-databases
#11
REVIEW
Miguel Cainzos-Achirica, Cristina Rebordosa, Emili Vela, Montse Cleries, Kunihiro Matsushita, Estel Plana, Elena Rivero-Ferrer, Cristina Enjuanes, Santiago Jimenez-Marrero, Luis Alberto Garcia-Rodriguez, Josep Comin-Colet, Susana Perez-Gutthann
Epidemiological studies on heart failure (HF) using large health care databases are becoming increasingly frequent, as they represent an invaluable opportunity to characterize the importance and risk factors of HF from a population perspective. Nevertheless, because of its complex diagnosis and natural history, the heterogeneous use of the relevant terminology in routine clinical practice, and the limitations of some disease coding systems, HF can be a challenging condition to assess using large health care databases as the main source of information...
May 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29901703/metamap-an-atlas-of-metatranscriptomic-reads-in-human-disease-related-rna-seq-data
#12
L M Simon, S Karg, A J Westermann, M Engel, A H A Elbehery, B Hense, M Heinig, L Deng, F J Theis
Background: With the advent of the age of big data in bioinformatics, large volumes of data and high performance computing power enable researchers to perform re-analyses of publicly available datasets at an unprecedented scale. Ever more studies imply the microbiome in both normal human physiology and a wide range of diseases. RNA sequencing technology (RNA-seq) is commonly used to infer global eukaryotic gene expression patterns under defined conditions, including human disease-related contexts, but its generic nature also enables the detection of microbial and viral transcripts...
June 12, 2018: GigaScience
https://www.readbyqxmd.com/read/29901168/a-three%C3%A2-lncrna-signature-for-prognosis-prediction-of-acute-myeloid-leukemia-in-patients
#13
Fangce Wang, Xiaoxue Tian, Jie Zhou, Guangming Wang, Wenlei Yu, Zheng Li, Zhuoyi Fan, Wenjun Zhang, Aibin Liang
Long non-coding RNAs (lncRNAs) are transcripts characterized by >200 nucleotides, without validated protein production. Previous studies have demonstrated that certain lncRNAs have a critical role in the initiation and development of acute myeloid leukemia (AML). In the present study, the subtype‑specific lncRNAs in AML was identified. Following the exclusion of the subtype‑specific lncRNAs, the prognostic value of lncRNAs was investigated and a three‑lncRNA expression‑based risk score [long intergenic non‑protein coding RNA 926, family with sequence similarity 30 member A and LRRC75A antisense RNA 1 (LRRC75A‑AS1)] was developed for AML patient prognosis prediction by analyzing the RNA‑seq data of AML patients from Therapeutically Available Research to Generate Effective Treatments (TARGET) and The Cancer Genome Atlas (TCGA) projects...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29899182/microarray-expression-profiling-of-micrornas-reveals-potential-biomarkers-for-hepatocellular-carcinoma
#14
Hai-Rong Zhu, Ren-Zheng Huang, Xiang-Nan Yu, Xuan Shi, Enkhnaran Bilegsaikhan, Hong-Ying Guo, Guang-Qi Song, Shu-Qiang Weng, Ling Dong, Harry L A Janssen, Xi-Zhong Shen, Ji-Min Zhu
Hepatocellular carcinoma (HCC) remains a major health problem for delayed diagnosis, inefficient surveillance and poor prognosis. Recent studies have indicated that non-coding RNAs contribute to the development of new strategies for diagnosis and treatment of HCC. In the present study, we employed 18 pairs of HCC and matched non-tumor tissues for the identification of differentially expressed microRNAs (miRNAs) in HCC, among which 7 paired specimens were selected randomly for microarray detection. Totally, twenty-three miRNAs were screened out to have statistically significant differences with the threshold of P < 0...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29899107/lncitprip-1-positively-regulates-innate-immune-response-through-promoting-oligomerization-and-activation-of-mda5
#15
Qinya Xie, Shengwen Chen, Renyun Tian, Xiang Huang, Rilin Deng, Binbin Xue, Yuwen Qin, Yan Xu, Jingjing Wang, Mengmeng Guo, Jinwen Chen, Songqing Tang, Guangdi Li, Haizhen Zhu
Emerging evidence indicates that long non-coding RNAs (lncRNAs) regulate various biological processes, especially innate and adaptive immunity. However, the relationship between lncRNAs and interferon (IFN) pathway remains largely unknown. Here, we report that lncRNA ITPRIP-1 (lncITPRIP-1) is involved in viral infection and plays a crucial role in virus-triggered IFN signaling pathway through targeting MDA5. LncITPRIP-1 can be induced by viral infection, which is not entirely dependent on IFN signal. Besides, there is no coding potential found in lncITPRIP-1 transcript...
June 13, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29898989/disruption-of-a-35kb-enhancer-impairs-ctcf-binding-and-mlh1-expression-in-colorectal-cells
#16
Qing Liu, Julie A Thoms, Andrea C Nunez, Yizhou Huang, Kathy Knezevic, Deborah Packham, Rebecca C Poulos, Rachel Williams, Dominik Beck, Nicholas J Hawkins, Robyn L Ward, Jason W H Wong, Luke B Hesson, Mathew A Sloane, John Pimanda
PURPOSE: MLH1 is a major tumour suppressor gene involved in the pathogenesis of Lynch syndrome and various sporadic cancers. Despite their potential pathogenic importance, genomic regions capable of regulating MLH1 expression over long distances have yet to be identified. EXPERIMENTAL DESIGN: Here we use chromosome conformation capture (3C) to screen a 650-kb region flanking the MLH1 locus to identify interactions between the MLH1 promoter and distal regions in MLH1 expressing and non-expressing cells...
June 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29898773/identification-of-a-new-allele-of-the-dw-gene-causing-brachytic-dwarfing-in-peach
#17
Celia M Cantín, Pere Arús, Iban Eduardo
OBJECTIVE: Peach brachytic dwarfism determined by Dwarf gene (Dw) is an undesired trait segregating in some peach breeding programs. Recently, a single nucleotide polymorphism (SNP) mutation in the gibberellin insensitive dwarf 1 (GID1) peach gene causing brachytic dwarfism was described. In this research we wanted to validate this marker in an F2 population of the 'Nectavantop' peach cultivar (Nv) to include it as a marker assisted selection tool for peach breeding programs. RESULTS: The observed segregation of the trait was in agreement with that of a recessive gene, the individuals homozygous for the recessive allele (dwdw) presenting the dwarf genotype...
June 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29897794/expanding-the-validity-of-the-level-of-personality-functioning-scale-observer-report-and-self-report-versions-across-psychodynamic-and-interpersonal-paradigms
#18
Michael J Roche, Nicholas C Jacobson, Jennifer J Phillips
The Level of Personality Functioning Scale (LPFS) operationalizes Criterion A of the DSM-5 alternative model for personality disorders. Yet, research on this measure has been slow to accumulate and questions remain regarding its reliability and validity. This study examined the LPFS observer-rated (OR) and self-report (SRA) versions of Criterion A in a sample of 240 students who provided psychological life history data and a variety of self-report measures. The results suggested the LPFS OR could be reliably coded, and the LPFS OR and LPFS SRA were significantly associated with outcome variables across psychodynamic and interpersonal paradigms...
June 13, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29897415/spatial-quantification-of-the-synaptic-activity-phenotype-across-large-populations-of-neurons-with-markov-random-fields
#19
Sean Robinson, Michael J Courtney
Motivation: The collective and coordinated synaptic activity of large neuronal populations is relevant to neuronal development as well as a range of neurological diseases. Quantification of synaptically-mediated neuronal signalling permits further downstream analysis as well as potential application in target validation and in vitro screening assays. Our aim is to develop a phenotypic quantification for neuronal activity imaging data of large populations of neurons, in particular relating to the spatial component of the activity...
April 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29896515/hyperedge-bundling-data-source-code-and-precautions-to-modeling-accuracy-bias-to-synchrony-estimates
#20
Sheng H Wang, Muriel Lobier, Felix Siebenhühner, Tuomas Puoliväli, Satu Palva, J Matias Palva
It has not been well documented that MEG/EEG functional connectivity graphs estimated with zero-lag-free interaction metrics are severely confounded by a multitude of spurious interactions (SI), i.e., the false-positive "ghosts" of true interactions [1], [2]. These SI are caused by the multivariate linear mixing between sources, and thus they pose a severe challenge to the validity of connectivity analysis. Due to the complex nature of signal mixing and the SI problem, there is a need to intuitively demonstrate how the SI are discovered and how they can be attenuated using a novel approach that we termed hyperedge bundling...
June 2018: Data in Brief
keyword
keyword
37432
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"