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https://www.readbyqxmd.com/read/28344689/exploring-social-media-and-admissions-decision-making-friends-or-foes
#1
Marcus Law, Maria Mylopoulos, Paula Veinot, Daniel Miller, Mark D Hanson
BACKGROUND: Despite the ever-increasing use of social media (e.g., Facebook, Twitter) little is known about its use in medical school admissions. This qualitative study explores whether and how social media (SM) is used in undergraduate admissions in Canada, and the attitudes of admissions personnel towards such use. METHODS: Phone interviews were conducted with admissions deans and nominated admissions personnel. A qualitative descriptive analysis was performed using iterative coding and comparing, and grouping data into themes...
October 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28343797/early-brain-edema-is-a-predictor-of-in-hospital-mortality-in-traumatic-brain-injury
#2
Brian Tucker, Jill Aston, Megan Dines, Elena Caraman, Marianne Yacyshyn, Mary McCarthy, James E Olson
BACKGROUND: Identifying patients who may progress to a poor clinical outcome will encourage earlier appropriate therapeutic interventions. Brain edema may contribute to secondary injury in traumatic brain injury (TBI) and thus, may be a useful prognostic indicator. OBJECTIVE: We determined whether the presence of brain edema on the initial computed tomography (CT) scan of TBI patients would predict poor in-hospital outcome. METHODS: We performed a retrospective review of all trauma patients with nonpenetrating head trauma at a Level I Trauma Center...
March 23, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28342698/targeted-exome-sequencing-and-chromosomal-microarray-for-the-molecular-diagnosis-of-nevoid-basal-cell-carcinoma-syndrome
#3
Yoshihiro Matsudate, Takuya Naruto, Yumiko Hayashi, Mitsuyoshi Minami, Mikiko Tohyama, Kenji Yokota, Daisuke Yamada, Issei Imoto, Yoshiaki Kubo
BACKGROUND: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder mainly caused by heterozygous mutations of PTCH1. In addition to characteristic clinical features, detection of a mutation in causative genes is reliable for the diagnosis of NBCCS; however, no mutations have been identified in some patients using conventional methods. OBJECTIVE: To improve the method for the molecular diagnosis of NBCCS. METHODS: We performed targeted exome sequencing (TES) analysis using a multi-gene panel, including PTCH1, PTCH2, SUFU, and other sonic hedgehog signaling pathway-related genes, based on next-generation sequencing (NGS) technology in 8 cases in whom possible causative mutations were not detected by previously performed conventional analysis and 2 recent cases of NBCCS...
March 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28341687/perspectives-on-procedure-based-assessments-a-thematic-analysis-of-semistructured-interviews-with-10-uk-surgical-trainees
#4
Joseph Shalhoub, Dominic C Marshall, Kate Ippolito
OBJECTIVES: The introduction of competency-based training has necessitated development and implementation of accompanying mechanisms for assessment. Procedure-based assessments (PBAs) are an example of workplace-based assessments that are used to examine focal competencies in the workplace. The primary objective was to understand surgical trainees' perspective on the value of PBA. DESIGN: Semistructured interviews with 10 surgical trainees individually interviewed to explore their views...
March 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28341492/understanding-antibiotic-decision-making-in-surgery-a-qualitative-analysis
#5
E Charani, C Tarrant, K Moorthy, N Sevdalis, L Brennan, A H Holmes
OBJECTIVE: To investigate the characteristics and culture of antibiotic decision making in the surgical specialty. METHODS: A qualitative study including ethnographic observation and face to face interviews with participants from six surgical teams at a teaching hospital in London was conducted. Over a three month period: 1) thirty ward rounds (WRs) (100 hours) were observed, 2) face-to-face follow up interviews took place with thirteen key informants, 3) multidisciplinary meetings on the management of surgical patients and daily practice on wards were observed...
March 21, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28341166/-identification-of-neurodegenerative-diseases-in-administrative-databases-in-france-a-systematic-review-of-the-literature
#6
REVIEW
A Gallini, F Moisan, G Maura, L Carcaillon-Bentata, E Leray, J Haesebaert, A Bruandet, E Moutengou, L Luciano, A Weill, B Marin, V Gardette
BACKGROUND: Given the health, social and economic burden of neurodegenerative diseases (ND), the development of epidemiologic studies is required. Administrative databases, such as the French national health insurance database (SNIIRAM) could represent an opportunity for researchers. ND could be presumed from drug reimbursement data, hospital stays or registration of a chronic condition. The aim of this study was to describe, in French administrative databases, algorithms used to identify Alzheimer's disease and associated disorders (ADAD), Parkinson's disease and associated disorders (PDAD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS)...
March 21, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28341145/facial-correlates-of-emotional-behaviour-in-the-domestic-cat-felis-catus
#7
Valerie Bennett, Nadine Gourkow, Daniel S Mills
Leyhausen's (1979) work on cat behaviour and facial expressions associated with offensive and defensive behaviour is widely embraced as the standard for interpretation of agonistic behaviour in this species. However, it is a largely anecdotal description that can be easily misunderstood. Recently a facial action coding system has been developed for cats (CatFACS), similar to that used for objectively coding human facial expressions. This study reports on the use of this system to describe the relationship between behaviour and facial expressions of cats in confinement contexts without and with human interaction, in order to generate hypotheses about the relationship between these expressions and underlying emotional state...
March 21, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28340901/predictive-validity-of-an-observer-rated-adherence-protocol-for-multisystemic-therapy-with-juvenile-drug-offenders
#8
Marie L Gillespie, Stanley J Huey, Phillippe B Cunningham
OBJECTIVE: Multisystemic therapy (MST) is perhaps the best validated treatment for youth who engage in serious and chronic antisocial behavior (Henggeler, Schoenwald, Borduin, Rowland, & Cunningham, 2009). Despite evidence suggesting that high treatment adherence is needed to achieve optimal MST outcomes, this research is limited because past studies have relied on adherence reports derived solely from treatment participants (i.e., caregivers, youth, and therapists). To address this gap in the literature, the present study assessed the reliability and predictive validity of an observational protocol for rating adherence to MST...
May 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28339644/development-and-validation-of-a-structured-query-language-implementation-of-the-elixhauser-comorbidity-index
#9
Richard H Epstein, Franklin Dexter
Objective: Comorbidity adjustment is often performed during outcomes and health care resource utilization research. Our goal was to develop an efficient algorithm in structured query language (SQL) to determine the Elixhauser comorbidity index. Materials and Methods: We wrote an SQL algorithm to calculate the Elixhauser comorbidities from Diagnosis Related Group and International Classification of Diseases (ICD) codes. Validation was by comparison to expected comorbidities from combinations of these codes and to the 2013 Nationwide Readmissions Database (NRD)...
February 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28338913/assessing-the-impact-of-unmeasured-confounding-for-binary-outcomes-using-confounding-functions
#10
Jessica Kasza, Rory Wolfe, Tibor Schuster
A critical assumption of causal inference is that of no unmeasured confounding: for estimated exposure effects to have valid causal interpretations, a sufficient set of predictors of exposure and outcome must be adequately measured and correctly included in the respective inference model(s). In an observational study setting, this assumption will often be unsatisfied, and the potential impact of unmeasured confounding on effect estimates should be investigated. The confounding function approach allows the impact of unmeasured confounding on estimates to be assessed, where unmeasured confounding may be due to unmeasured confounders and/or biases such as collider bias or information bias...
March 3, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28338834/comparative-genomics-of-microsporidian-genomes-reveals-a-minimal-non-coding-rna-set-and-new-insights-for-transcription-in-minimal-eukaryotic-genomes
#11
Abdel Belkorchia, Jean-François Pombert, Valérie Polonais, Nicolas Parisot, Frédéric Delbac, Jean-François Brugère, Pierre Peyret, Christine Gaspin, Eric Peyretaillade
Microsporidia are ubiquitous intracellular pathogens whose opportunistic nature led to their increased recognition with the rise of the AIDS pandemic. As the RNA world was largely unexplored in this parasitic lineage, we developed a dedicated in silico methodology to carry out exhaustive identification of ncRNAs across the Encephalitozoon and Nosema genera. Thus, the previously missing U1 small nuclear RNA (snRNA) and small nucleolar RNAs (snoRNAs) targeting only the LSU rRNA were highlighted and were further validated using 5' and 3'RACE-PCR experiments...
February 28, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28336380/risk-prediction-models-for-incident-heart-failure-a-systematic-review-of-methodology-and-model-performance
#12
REVIEW
Berhe W Sahle, Alice J Owen, Ken Lee Chin, Christopher M Reid
BACKGROUND: Numerous models predicting the risk of incident heart failure (HF) have been developed, however evidence of their methodological rigour and reporting remains unclear. This study critically appraises the methods underpinning incident HF risk prediction models. METHODS AND RESULTS: EMBASE and PubMed were searched for articles published between 1990 and June 2016 that reported at least one multivariable model for prediction of HF. Model development information, including study design, variable coding, missing data, and predictor selection, was extracted...
March 21, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28335741/high-throughput-sequencing-of-pituitary-and-hypothalamic-microrna-transcriptome-associated-with-high-rate-of-egg-production
#13
Nan Wu, Qing Zhu, Binlong Chen, Jian Gao, Zhongxian Xu, Diyan Li
BACKGROUND: MicroRNAs exist widely in viruses, plants and animals. As endogenous small non-coding RNAs, miRNAs regulate a variety of biological processes. Tissue miRNA expression studies have discovered numerous functions for miRNAs in various tissues of chicken, but the regulation of miRNAs in chicken pituitary and hypothalamic development related to high and low egg-laying performance has remained unclear. RESULTS: In this study, using high-throughput sequencing technology, we sequenced two tissues (pituitary and hypothalamus) in 3 high- and 3 low-rate egg production Luhua chickens at the age of 300 days...
March 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28335561/optimal-power-allocation-of-relay-sensor-node-capable-of-energy-harvesting-in-cooperative-cognitive-radio-network
#14
Pham Ngoc Son, Dongsoo Har, Nam Ik Cho, Hyung Yun Kong
A cooperative cognitive radio scheme exploiting primary signals for energy harvesting is proposed. The relay sensor node denoted as the secondary transmitter (ST) harvests energy from the primary signal transmitted from the primary transmitter, and then uses it to transmit power superposed codes of the secrecy signal of the secondary network (SN) and of the primary signal of the primary network (PN). The harvested energy is split into two parts according to a power splitting ratio, one for decoding the primary signal and the other for charging the battery...
March 21, 2017: Sensors
https://www.readbyqxmd.com/read/28334889/the-primary-transcriptome-of-neisseria-meningitidis-and-its-interaction-with-the-rna-chaperone-hfq
#15
Nadja Heidrich, Saskia Bauriedl, Lars Barquist, Lei Li, Christoph Schoen, Jörg Vogel
Neisseria meningitidis is a human commensal that can also cause life-threatening meningitis and septicemia. Despite growing evidence for RNA-based regulation in meningococci, their transcriptome structure and output of regulatory small RNAs (sRNAs) are incompletely understood. Using dRNA-seq, we have mapped at single-nucleotide resolution the primary transcriptome of N. meningitidis strain 8013. Annotation of 1625 transcriptional start sites defines transcription units for most protein-coding genes but also reveals a paucity of classical σ70-type promoters, suggesting the existence of activators that compensate for the lack of -35 consensus sequences in N...
March 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334830/predicting-the-impact-of-non-coding-variants-on-dna-methylation
#16
Haoyang Zeng, David K Gifford
DNA methylation plays a crucial role in the establishment of tissue-specific gene expression and the regulation of key biological processes. However, our present inability to predict the effect of genome sequence variation on DNA methylation precludes a comprehensive assessment of the consequences of non-coding variation. We introduce CpGenie, a sequence-based framework that learns a regulatory code of DNA methylation using a deep convolutional neural network and uses this network to predict the impact of sequence variation on proximal CpG site DNA methylation...
March 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334741/benchmarks-for-measurement-of-duplicate-detection-methods-in-nucleotide-databases
#17
Qingyu Chen, Justin Zobel, Karin Verspoor
Duplication of information in databases is a major data quality challenge. The presence of duplicates, implying either redundancy or inconsistency, can have a range of impacts on the quality of analyses that use the data. To provide a sound basis for research on this issue in databases of nucleotide sequences, we have developed new, large-scale validated collections of duplicates, which can be used to test the effectiveness of duplicate detection methods. Previous collections were either designed primarily to test efficiency, or contained only a limited number of duplicates of limited kinds...
January 8, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28334561/determining-current-insulin-pen-use-practices-and-errors-in-the-inpatient-setting
#18
Katelyn E Brown, John B Hertig
BACKGROUND: The use of insulin pens in the inpatient setting has continued to be a controversial decision. Insulin pens provide several advantages, but given significant reports of medication errors, several organizations have issued alerts to caution users about safety concerns. A survey was conducted to assess the prevalence of insulin pen use and current utilization trends in the inpatient setting. METHODS: The 31-question guided-logic survey was developed based on review of primary literature regarding insulin pen utilization and evaluated by a panel of medication safety experts from a variety of health care settings...
December 2016: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28334114/biren-predicting-enhancers-with-a-deep-learning-based-model-using-the-dna-sequence-alone
#19
Bite Yang, Feng Liu, Chao Ren, Zhangyi Ouyang, Ziwei Xie, Xiaochen Bo, Wenjie Shu
Motivation: Enhancer elements are noncoding stretches of DNA that play key roles in controlling gene expression programmes. Despite major efforts to develop accurate enhancer prediction methods, identifying enhancer sequences continues to be a challenge in the annotation of mammalian genomes. One of the major issues is the lack of large, sufficiently comprehensive and experimentally validated enhancers for humans or other species. Thus, the development of computational methods based on limited experimentally validated enhancers and deciphering the transcriptional regulatory code encoded in the enhancer sequences is urgent...
February 17, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28334030/measuring-mortality-due-to-hiv-associated-tuberculosis-among-adults-in-south-africa-comparing-verbal-autopsy-minimally-invasive-autopsy-and-research-data
#20
Aaron S Karat, Mpho Tlali, Katherine L Fielding, Salome Charalambous, Violet N Chihota, Gavin J Churchyard, Yasmeen Hanifa, Suzanne Johnson, Kerrigan McCarthy, Neil A Martinson, Tanvier Omar, Kathleen Kahn, Daniel Chandramohan, Alison D Grant
BACKGROUND: The World Health Organization (WHO) aims to reduce tuberculosis (TB) deaths by 95% by 2035; tracking progress requires accurate measurement of TB mortality. International Classification of Diseases (ICD) codes do not differentiate between HIV-associated TB and HIV more generally. Verbal autopsy (VA) is used to estimate cause of death (CoD) patterns but has mostly been validated against a suboptimal gold standard for HIV and TB. This study, conducted among HIV-positive adults, aimed to estimate the accuracy of VA in ascertaining TB and HIV CoD when compared to a reference standard derived from a variety of clinical sources including, in some, minimally-invasive autopsy (MIA)...
2017: PloS One
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