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https://www.readbyqxmd.com/read/29241106/differentials-and-trends-in-emergency-department-visits-due-to-alcohol-intoxication-and-co-occurring-conditions-among-students-in-a-u-s-public-university
#1
Duc Anh Ngo, Nassima Ait-Daoud, Saumitra V Rege, Christopher Ding, Lauren Gallion, Susan Davis, Christopher P Holstege
BACKGROUND: Few studies have explored the epidemiology of students presenting to the emergency department (ED) as a consequence of hazardous drinking. This study examined differentials and trends in ED visits following alcohol intoxication and co-occurring conditions among students presenting to a major U.S. university health system. METHODS: The ED electronic medical records from academic years 2010-2015 were queried for student visits and their records were linked to the university's student admission datasets...
December 9, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29240798/the-cost-of-comorbidities-in-treatment-for-hiv-aids-in-california
#2
David S Zingmond, Kodi B Arfer, Jennifer L Gildner, Arleen A Leibowitz
BACKGROUND: Antiretroviral therapy has increased longevity for people living with HIV (PLWH). As a result, PLWH increasingly experience the common diseases of aging and the resources needed to manage these comorbidities are increasing. This paper characterizes the number and types of comorbidities diagnosed among PLWH covered by Medicare and examines how non-HIV comorbidities relate to outpatient, inpatient, and pharmaceutical expenditures. METHODS: The study examined Medicare expenditures for 9767 HIV-positive Californians enrolled in Medicare in 2010 (7208 persons dually covered by Medicare and Medicaid and 2559 with Medicare only)...
2017: PloS One
https://www.readbyqxmd.com/read/29240762/rethinking-3r-strategies-digging-deeper-into-animaltestinfo-promotes-transparency-in-in-vivo-biomedical-research
#3
Bettina Bert, Antje Dörendahl, Nora Leich, Julia Vietze, Matthias Steinfath, Justyna Chmielewska, Andreas Hensel, Barbara Grune, Gilbert Schönfelder
In the European Union (EU), animal welfare is seen as a matter of great importance. However, with respect to animal experimentation, European citizens feel quite uninformed. The European Directive 2010/63/EU for the protection of laboratory animals aims for greater transparency and requires that a comprehensible, nontechnical summary (NTS) of each authorised research project involving animals is published by the respective Member State. However, the NTSs remain sleeping beauties if their contents are not easily and systematically accessible...
December 2017: PLoS Biology
https://www.readbyqxmd.com/read/29240091/hyperspectral-image-compression-approaches-opportunities-challenges-and-future-directions-discussion
#4
Rui Dusselaar, Manoranjan Paul
This paper establishes a review of the recent study in the field of hyperspectral (HS) image compression approaches. Recently, image compression techniques have achieved significant advances from diverse types of coding standards/approaches. HS image compression requires an unconventional coding technique because of its unique, multiple-dimensional structure. The data redundancy exists in both inter-band and intra-band methods. The survey summarizes current literature in inter- and intra-band compression methods...
December 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29240000/complete-versus-staged-repair-for-neonates-with-tetralogy-of-fallot-establishment-and-validation-of-a-cohort-of-2235-patients-using-detailed-surgery-sequence-review-of-health-care-administrative-data
#5
Jill J Savla, Brian T Fisher, Jennifer A Faerber, Yuan-Shung V Huang, Laura Mercer-Rosa
BACKGROUND: The surgical strategy for neonates with tetralogy of Fallot (TOF) consists of complete or staged repair. Assessing the comparative effectiveness of these approaches is facilitated by a large multicenter cohort. We propose a novel process for cohort assembly using the Pediatric Health Information System (PHIS), an administrative database that contains clinical and billing data for inpatient and emergency department stays from tertiary children's hospitals. METHODS: A 4-step process was used to identify neonates with TOF: (1) screen neonates in PHIS with International Classification of Diseases-9 (ICD-9) diagnosis or procedure codes for TOF; (2) include patients with TOF procedures before 30 days of age; (3) exclude patients with missing 2-year follow-up data; (4) analyze patients' 2-year surgery sequence patterns, exclude patients inconsistent with a treatment strategy for TOF, and designate patients as complete or staged repair...
December 12, 2017: Medical Care
https://www.readbyqxmd.com/read/29237851/micrornas-regulate-the-sesquiterpenoid-hormonal-pathway-in-drosophila-and-other-arthropods
#6
Zhe Qu, William G Bendena, Wenyan Nong, Kenneth W Siggens, Fernando G Noriega, Zhen-Peng Kai, Yang-Yang Zang, Alex C Koon, Ho Yin Edwin Chan, Ting Fung Chan, Ka Hou Chu, Hon Ming Lam, Michael Akam, Stephen S Tobe, Jerome Ho Lam Hui
Arthropods comprise the majority of all described animal species, and understanding their evolution is a central question in biology. Their developmental processes are under the precise control of distinct hormonal regulators, including the sesquiterpenoids juvenile hormone (JH) and methyl farnesoate. The control of the synthesis and mode of action of these hormones played important roles in the evolution of arthropods and their adaptation to diverse habitats. However, the precise roles of non-coding RNAs, such as microRNAs (miRNAs), controlling arthropod hormonal pathways are unknown...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29236940/polyclonal-rb1-mutations-and-acquired-resistance-to-cdk-4-6-inhibitors-in-patients-with-metastatic-breast-cancer
#7
R Condorelli, L Spring, J O'Shaughnessy, L Lacroix, C Bailleux, V Scott, J Dubois, R J Nagy, R B Lanman, A J Iafrate, F Andre, A Bardia
Background: While deregulation of the cyclin D1-CDK4/6-retinoblastoma pathway is common in hormone receptor positive (HR+) breast cancer, Rb is usually intact in HR+ breast cancer, and targeted CDK 4/6 inhibitors that act upstream of Rb, are routinely being utilized in clinical practice. However, factors that can lead to clinical resistance to CDK 4/6 inhibitors are not known. Patients and methods: We identified patients who had pre and post genotyping in tissue and peripheral blood samples after receiving CDK 4/6 inhibitors...
December 11, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29236709/cirs-7-exonic-sequence-is-embedded-in-a-long-non-coding-rna-locus
#8
Steven P Barrett, Kevin R Parker, Caroline Horn, Miguel Mata, Julia Salzman
ciRS-7 is an intensely studied, highly expressed and conserved circRNA. Essentially nothing is known about its biogenesis, including the location of its promoter. A prevailing assumption has been that ciRS-7 is an exceptional circRNA because it is transcribed from a locus lacking any mature linear RNA transcripts of the same sense. To study the biogenesis of ciRS-7, we developed an algorithm to define its promoter and predicted that the human ciRS-7 promoter coincides with that of the long non-coding RNA, LINC00632...
December 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29236517/epidemiology-of-hypersensitivity-pneumonitis-among-an-insured-population-in-the-united-states-a-claims-based-cohort-analysis
#9
Evans R Fernández Pérez, Amanda M Kong, Karina Raimundo, Tilman L Koelsch, Rucha Kulkarni, Ashley L Cole
RATIONALE: Hypersensitivity pneumonitis is a complex lung disease resulting from repeated inhalation of a variety of antigens. Limited data exist regarding its epidemiology. OBJECTIVE: To describe the trends in the annual incidence and prevalence of hypersensitivity pneumonitis in the US. METHODS: We developed novel claims-based coding algorithms to identify hypersensitivity pneumonitis, chronic hypersensitivity pneumonitis, and fibrotic hypersensitivity pneumonitis cases using the 2004-2013 MarketScan Commercial and Medicare Supplemental healthcare claims databases...
December 13, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29236234/assessment-of-the-functional-impact-of-germline-brca1-2-variants-located-in-non-coding-regions-in-families-with-breast-and-or-ovarian-cancer-predisposition
#10
E Santana Dos Santos, S M Caputo, L Castera, M Gendrot, A Briaux, M Breault, S Krieger, P K Rogan, E J Mucaki, L J Burke, I Bièche, C Houdayer, D Vaur, D Stoppa-Lyonnet, M A Brown, F Lallemand, E Rouleau
PURPOSE: The molecular mechanism of breast and/or ovarian cancer susceptibility remains unclear in the majority of patients. While germline mutations in the regulatory non-coding regions of BRCA1 and BRCA2 genes have been described, screening has generally been limited to coding regions. The aim of this study was to evaluate the contribution of BRCA1/2 non-coding variants. METHODS: Four BRCA1/2 non-coding regions were screened using high-resolution melting analysis/Sanger sequencing or next-generation sequencing on DNA extracted from index cases with breast and ovarian cancer predisposition (3926 for BRCA1 and 3910 for BRCA2)...
December 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29234695/an-improved-draft-of-the-pigeonpea-cajanus-cajan-l-millsp-genome
#11
Ajay Kumar Mahato, Ajay Kumar Sharma, Tilak Raj Sharma, Nagendra Kumar Singh
The first draft of the pigeonpea (Cajanus cajan (L.) Millsp. cv. Asha) genome with 511 Mbp of assembled sequence information has low genome coverage of about sixty percent. Here we present an improved version of this genome with 648.2 Mbp of assembled sequence of this popular pigeonpea variety, which is liked by the millers and has resistance to fusarium wilt and sterility mosaic diseases. With the addition of 137 Mb of assembled sequence information the present version has the highest available genome coverage of pigeonpea till date...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29234333/putative-microsatellite-dna-marker-based-wheat-genomic-resource-for-varietal-improvement-and-management
#12
Sarika Jaiswal, Sonia Sheoran, Vasu Arora, Ulavappa B Angadi, Mir A Iquebal, Nishu Raghav, Bharti Aneja, Deepender Kumar, Rajender Singh, Pradeep Sharma, G P Singh, Anil Rai, Ratan Tiwari, Dinesh Kumar
Wheat fulfills 20% of global caloric requirement. World needs 60% more wheat for 9 billion population by 2050 but climate change with increasing temperature is projected to affect wheat productivity adversely. Trait improvement and management of wheat germplasm requires genomic resource. Simple Sequence Repeats (SSRs) being highly polymorphic and ubiquitously distributed in the genome, can be a marker of choice but there is no structured marker database with options to generate primer pairs for genotyping on desired chromosome/physical location...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29233588/changes-in-circulating-mirnas-in-healthy-overweight-and-obese-subjects-effect-of-diet-composition-and-weight-loss
#13
S Giardina, P Hernández-Alonso, A Díaz-López, A Salas-Huetos, J Salas-Salvadó, M Bulló
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA molecules that can play an important role in several chronic metabolic conditions, including obesity. However, to date little is known about how they are regulated. Weight loss induced by surgical procedures has been effective at modulating specific circulating miRNAs, but the effect of energy-restricted diets with different macronutrient compositions on circulating miRNAs is not well understood. The objective of the present analysis was to explore the effect of three energy-restricted diets of different macronutrient composition and carbohydrate quality on plasma miRNA levels...
December 1, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29233439/an-investigation-of-final-year-pharmacy-students-moral-reasoning-ability-and-their-views-on-professionalism-and-fitness-to-practice-panel-determinations-a-questionnaire-study
#14
Lezley-Anne Hanna, John Gillen, Maurice Hall
BACKGROUND AND PURPOSE: The aim was to establish pharmacy students' moral reasoning ability and obtain their views on professionalism and fitness to practice (FtP) determinations involving pharmacists. EDUCATIONAL ACTIVITY AND SETTING: Following ethical approval and piloting, final year pharmacy students at Queen's University Belfast (QUB) (n=119) were invited to participate in a questionnaire study. Section A was a validated moral reasoning assessment tool [Defining Issues Test (DIT2); five moral dilemmas], Section B was FtP cases and professionalism...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233244/modeling-predictors-of-duties-not-including-flying-status
#15
Anthony P Tvaryanas, Converse Griffith
INTRODUCTION: The purpose of this study was to reuse available datasets to conduct an analysis of potential predictors of U.S. Air Force aircrew nonavailability in terms of being in "duties not to include flying" (DNIF) status. METHODS: This study was a retrospective cohort analysis of U.S. Air Force aircrew on active duty during the period from 2003-2012. Predictor variables included age, Air Force Specialty Code (AFSC), clinic location, diagnosis, gender, pay grade, and service component...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29233155/a-meta-model-for-computer-executable-dynamic-clinical-safety-checklists
#16
Shan Nan, Pieter Van Gorp, Xudong Lu, Uzay Kaymak, Hendrikus Korsten, Richard Vdovjak, Huilong Duan
BACKGROUND: Safety checklist is a type of cognitive tool enforcing short term memory of medical workers with the purpose of reducing medical errors caused by overlook and ignorance. To facilitate the daily use of safety checklists, computerized systems embedded in the clinical workflow and adapted to patient-context are increasingly developed. However, the current hard-coded approach of implementing checklists in these systems increase the cognitive efforts of clinical experts and coding efforts for informaticists...
December 12, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29232349/management-of-intussusception-in-the-pediatric-emergency-department-risk-factors-for-recurrence
#17
Andrea Vo, Terry L Levin, Benjamin Taragin, Hnin Khine
BACKGROUND: The standard treatment for intussusception is air reduction enema (ARE) with inpatient observation for 24 to 48 hours to monitor for recurrence. More recent but limited observations suggest that patients who have undergone successful ARE can safely be discharged after 4 to 6 hours of observation. Our primary objective was to identify risk factors associated with early recurrence. Our secondary objectives included validating risk criteria from prior studies and identifying risk factors for ARE failures...
December 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29232182/design-and-technical-validation-of-a-telemedicine-service-for-rural-healthcare-in-ecuador
#18
Leonel A Vasquez-Cevallos, Jana Bobokova, Patricia V González-Granda, José M Iniesta, Enrique J Gómez, M Elena Hernando
BACKGROUND: Telemedicine is becoming increasingly important in Ecuador, especially in areas such as rural primary healthcare and medical education. Rural telemedicine programs in the country need to be strengthened by means of a technological platform adapted to local surroundings and offering advantages such as access to specialized care, continuing education, and so on, combined with modest investment requirements. INTRODUCTION: This present article presents the design of a Telemedicine Platform (TMP) for rural healthcare services in Ecuador and a preliminary technical validation with medical students and teachers...
December 12, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29231872/a-deeper-examination-of-thorellius-atrox-scorpion-venom-components-with-omic-techonologies
#19
Teresa Romero-Gutierrez, Esteban Peguero-Sanchez, Miguel A Cevallos, Cesar V F Batista, Ernesto Ortiz, Lourival D Possani
This communication reports a further examination of venom gland transcripts and venom composition of the Mexican scorpion Thorellius atrox using RNA-seq and tandem mass spectrometry. The RNA-seq, which was performed with the Illumina protocol, yielded more than 20,000 assembled transcripts. Following a database search and annotation strategy, 160 transcripts were identified, potentially coding for venom components. A novel sequence was identified that potentially codes for a peptide with similarity to spider ω-agatoxins, which act on voltage-gated calcium channels, not known before to exist in scorpion venoms...
December 12, 2017: Toxins
https://www.readbyqxmd.com/read/29230233/whole-genome-sequencing-of-fusarium-fujikuroi-provides-insight-into-the-role-of-secretory-proteins-and-cell-wall-degrading-enzymes-in-causing-bakanae-disease-of-rice
#20
Bishnu M Bashyal, Kirti Rawat, Sapna Sharma, Deepika Kulshreshtha, S Gopala Krishnan, Ashok K Singh, Himanshu Dubey, Amolkumar U Solanke, T R Sharma, Rashmi Aggarwal
Fusarium fujikuroi causing bakanae disease has emerged as one of the major pathogen of rice across the world. The study aims to comparative genomic analysis of Fusarium fujikuroi isolates and identification of the secretary proteins of the fungus involved in rice pathogenesis. In the present study, F. fujikuroi isolate "F250" was sequenced with an assembly size of 42.47 Mb providing coverage of 96.89% on reference IMI58289 genome. A total of 13,603 protein-coding genes were predicted from genome assembly. The average gene density in the F...
2017: Frontiers in Plant Science
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