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https://www.readbyqxmd.com/read/29454159/an-aligned-porous-electrospun-fibrous-membrane-with-controlled-drug-delivery-an-efficient-strategy-to-accelerate-diabetic-wound-healing-with-improved-angiogenesis
#1
Xiaozhi Ren, Yiming Han, Jie Wang, Yuqi Jiang, Zhengfang Yi, He Xu, Qinfei Ke
A chronic wound in diabetic patients is usually characterized by poor angiogenesis and delayed wound closure. The exploration of efficient strategy to significantly improve angiogenesis in the diabetic wound bed and thereby accelerate wound healing is still a significant challenge. Herein, we reported a kind of aligned porous poly (L-lactic acid) (PLLA) electrospun fibrous membranes containing dimethyloxalylglycine (DMOG)-loaded mesoporous silica nanoparticles (DS) for diabetic wound healing. The PLLA electrospun fibers aligned in a single direction and there were ellipse-shaped nano-pores in situ generated onto the surface of fibers, while the DS were well distributed in the fibers and the DMOG as well as Si ion could be controlled released from the nanopores on the fibers...
February 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29454040/development-of-an-unrelated-donor-selection-score-predictive-of-survival-after-hct-donor-age-matters-most
#2
Bronwen E Shaw, Brent R Logan, Stephen R Spellman, Steven G E Marsh, James Robinson, Joseph Pidala, Carolyn Hurley, Juliet Barker, Martin Maiers, Jason Dehn, Hailin Wang, Mike Haagenson, David Porter, Effie W Petersdorf, Ann Woolfrey, Mary M Horowitz, Michael Verneris, Katharine C Hsu, Katharina Fleischhauer, Stephanie J Lee
Donor factors, in addition to HLA matching status, have been associated with recipient survival in unrelated donor (URD) hematopoietic cell transplantation (HCT), however there is no hierarchical algorithm that weights the characteristics of individual donors against each other in a quantitative manner to facilitate donor selection. The goal of this study was to develop and validate a donor selection score that prioritizes donor characteristics associated with better survival in 8/8 HLA-matched URDs. Two separate patient/donor cohorts, the first receiving HCT between 1999-2011 (n=5952, c1), and the second between 2012-2014 (n=4510, c2) were included in the analysis...
February 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29453769/hpv-genotyping-for-the-cross-sectional-and-longitudinal-probability-of-developing-cin2
#3
Annarosa Del Mistro, Rachael Adcock, Francesca Carozzi, Anna Gillio-Tos, Laura De Marco, Salvatore Girlando, Raffaella Rizzolo, Helena Frayle, Morena Trevisan, Cristina Sani, Elena Burroni, Paolo Giorgi Rossi, Jack Cuzick, Guglielmo Ronco
HPV testing is more sensitive but less specific than cytology. We evaluated stand-alone genotyping as a possible triage method. During a multicentre randomised controlled trial comparing HPV testing to conventional cytology, HPV positive women were referred to colposcopy and followed up if no high-grade lesion was detected. HPV positive samples were genotyped by GP5+/GP6+ primed PCR followed by reverse line blot. Genotypes were hierarchically ordered by positive predictive value (PPV) for CIN grade 2 or more (CIN2+), and grouped by cluster analysis into 3 groups (A, B and C in decreasing order)...
February 17, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29453587/trimorphic-extreme-clubfoot-deformities-and-their-management-by-triple-surgical-skin-expanders-dolar-dolarz-and-dolarz-e-evidence-based-mega-corrections-without-arthrodesis
#4
Rattan L Mittal
AIM/PURPOSE: Extreme congenital club foot deformities are common in developing countries, presenting at birth, persisting in children, adolescents and adults; as untreated/under-corrected by conservative and/or surgical means. Scores of confusing names exist in literature for such deformities with no good treatment available; mostly advocating unacceptable arthrodesis. The author researched this grey area for more than 40 years and successfully innovated improved surgical corrections, more acceptable to patients...
February 17, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29453295/socioeconomic-religious-spiritual-and-health-factors-associated-with-symptoms-of-common-mental-disorders-a-cross-sectional-secondary-analysis-of-data-from-bhutan-s-gross-national-happiness-study-2015
#5
Gyambo Sithey, Mu Li, Li Ming Wen, Patrick J Kelly, Kelly Clarke
OBJECTIVE: Common mental disorders (CMDs) are a major cause of the global burden of disease. Bhutan was the first country in the world to focus on happiness as a state policy; however, little is known about the prevalence and risk factors of CMDs in this setting. We aim to identify socioeconomic, religious, spiritual and health factors associated with symptoms of CMDs. DESIGN AND SETTING: We used data from Bhutan's 2015 Gross National Happiness (GNH) Survey, a multistage, cross-sectional nationwide household survey...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453294/public-preferences-for-interventions-to-prevent-emerging-infectious-disease-threats-a-discrete-choice-experiment
#6
Alex R Cook, Xiahong Zhao, Mark I C Chen, Eric A Finkelstein
OBJECTIVE: When faced with an emergent epidemic with high mortality and morbidity potential, policy makers must decide what public health interventions to deploy at different stages of the outbreak. However, almost nothing is known about how the public view these interventions or how they trade off risks (of disease) with inconvenience (of interventions). In this paper, we aim to understand public perceptions on pandemic interventions, as well as to identify if there are any distinct respondent preference classes...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453228/targeted-profiling-of-a-thaliana-sub-proteomes-illuminates-new-co-and-post-translationally-n-terminal-myristoylated-proteins
#7
Wojciech Majeran, Jean-Pierre Le Caer, Lalit Ponnala, Thierry Meinnel, Carmela Giglione
N-terminal myristoylation (MYR) is a biologically important co-translational protein lipidation. MYR is difficult to detect in vivo and challenging to predict in silico. We developed a targeted proteomics strategy to identify the Arabidopsis thaliana myristoylated (MYRed) proteome in specific sub-cellular compartments. This global profiling approach allowed us to: (i) identify one third of all open reading frames of the A. thaliana proteome including 54% of the predicted myristoylome; and (ii) establish the first comprehensive plant myristoylome, featuring direct evidence of MYR in 72 proteins...
February 16, 2018: Plant Cell
https://www.readbyqxmd.com/read/29453050/enhancement-in-the-aromatic-yield-from-the-catalytic-fast-pyrolysis-of-rice-straw-over-hexadecyl-trimethyl-ammonium-bromide-modified-hierarchical-hzsm-5
#8
Zihao Zhang, Hao Cheng, Hao Chen, Kequan Chen, Xiuyang Lu, Pingkai Ouyang, Jie Fu
Modified H-type ZSM-5 (HZSM-5) catalysts were prepared using hexadecyl trimethyl ammonium bromide (CTAB) as mesopore templates to enhance the activity for the catalytic fast pyrolysis of rice straw for aromatics compounds. A certain quantity of CTAB added into the HZSM-5 (HZ) forming hierarchical structure exhibited an improvement in the yield of the aromatics and a decrease in the yield of coke in comparison with that of bare HZ. In contrast, excessive CTAB addition resulted in a decrease in aromatic yield and an increase in coke yield...
February 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29452025/subgrouping-the-users-of-a-specialized-app-for-eating-disorders
#9
Shiri Sadeh-Sharvit, Jane Paik Kim, Alison M Darcy, Eric Neri, Molly Vierhile, Athena Robinson, Jenna Tregarthen, James D Lock
Although mobile technologies for eating disorders (EDs) are burgeoning, there is limited data about the clinical characteristics of individuals using specialized smartphone applications (apps) without accompanying traditional forms of treatment. This study evaluated whether the users of an ED app cluster in clinically meaningful groups. Participants were 1,280 app users (91.3% female; mean age 27) who reported not being in a weekly treatment for their ED. A hierarchical cluster analysis distinguished five groups of participants, all approximating DSM-5 ED categories...
February 16, 2018: Eating Disorders
https://www.readbyqxmd.com/read/29451956/posttraumatic-stress-disorder-ptsd-and-complex-ptsd-cptsd-as-per-icd-11-proposals-a-population-study-in-israel
#10
Menachem Ben-Ezra, Thanos Karatzias, Philip Hyland, Chris R Brewin, Marylene Cloitre, Jonathan I Bisson, Neil P Roberts, Brigitte Lueger-Schuster, Mark Shevlin
BACKGROUND: The current study sought to advance the existing literature by providing the first assessment of the factorial and discriminant validity of the ICD-11 proposals for posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) in a nationwide level. METHODS: A nationally representative sample from Israel (n = 1,003) using a disorder-specific measure (ITQ; International Trauma Questionnaire) in order to assess PTSD and CPTSD along with the Life Events Checklist and the World Health Organization Well-Being Index...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451884/a-damped-oscillator-imposes-temporal-order-on-posterior-gap-gene-expression-in-drosophila
#11
Berta Verd, Erik Clark, Karl R Wotton, Hilde Janssens, Eva Jiménez-Guri, Anton Crombach, Johannes Jaeger
Insects determine their body segments in two different ways. Short-germband insects, such as the flour beetle Tribolium castaneum, use a molecular clock to establish segments sequentially. In contrast, long-germband insects, such as the vinegar fly Drosophila melanogaster, determine all segments simultaneously through a hierarchical cascade of gene regulation. Gap genes constitute the first layer of the Drosophila segmentation gene hierarchy, downstream of maternal gradients such as that of Caudal (Cad). We use data-driven mathematical modelling and phase space analysis to show that shifting gap domains in the posterior half of the Drosophila embryo are an emergent property of a robust damped oscillator mechanism, suggesting that the regulatory dynamics underlying long- and short-germband segmentation are much more similar than previously thought...
February 16, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29451860/a-hierarchical-bayesian-tri-variate-analysis-on-factors-associated-with-anthropometric-measures-in-a-large-sample-of-children-and-adolescents-the-caspian-iv-study
#12
Roya Kelishadi, Zahra Heidari, Iraj Kazemi, Tohid Jafari-Koshki, Marjan Mansourian, Mohammad-Esmaeil Motlagh, Ramin Heshmat
BACKGROUND: This study aimed to assess determinants of anthropometric measures in a nationally representative sample of Iranian children and adolescents. METHODS: This nationwide study was conducted among 13,280 students, aged 6-18 years, who were randomly selected from 30 provinces in Iran. Anthropometric measures were determined by calibrated instruments. Demographic and socio-economic (SES) variables, lifestyle behaviors, family history of chronic disease and prenatal factors were studied, as well...
February 16, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29451851/validation-of-a-pre-existed-safety-climate-scale-for-turkish-furniture-manufacturing-industry
#13
Kadri Cemil Akyuz, Ibrahim Yıldirim, Celal Gungor
Understanding the safety climate level is essential to implement a proactive safety program. The objective of this study is to explore the possibility of having a safety climate scale for the Turkish furniture manufacturing industry since there has not been any scale available. The questionnaire recruited 783 subjects. A confirmatory factor analysis (CFA) tested a pre-existed safety scale's fit to the industry. The CFA indicated that the structures of the model present a non-satisfactory fit with the data (χ 2 = 2,033...
February 16, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29451495/perceptually-aware-image-retargeting-for-mobile-devices
#14
Yinzuo Zhou, Luming Zhang, Chao Zhang, Ping Li, Xuelong Li
Retargeting aims at adapting an original high-resolution photograph/video to a low-resolution screen with an arbitrary aspect ratio. Conventional approaches are generally based on desktop PCs, since the computation might be intolerable for mobile platforms (especially when retargeting videos). Typically, only low-level visual features are exploited, and human visual perception is not well encoded. In this paper, we propose a novel retargeting framework that rapidly shrinks a photograph/video by leveraging human gaze behavior...
May 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29451429/perceived-injustice-in-chronic-pain-an-examination-through-the-lens-of-predictive-processing
#15
Daniel A Bissell, Maisa S Ziadni, John A Sturgeon
Chronic pain conditions have been shown to be exacerbated by psychological factors, and a better understanding of these factors can inform clinical practice and improve the efficacy of interventions. The current paper investigates perceived injustice, a novel psychosocial construct, within a framework influenced by the tenets of predictive processing. The proposed conceptual model derived from tenets of predictive processing yields a single hierarchical self-reconfiguring system driven by prediction, which accounts for a wide range of human experiences such as perception, behavior, learning and emotion...
February 16, 2018: Pain Management
https://www.readbyqxmd.com/read/29451304/distinct-methylation-profile-of-mucinous-ovarian-carcinoma-reveals-susceptibility-to-proteasome-inhibitors
#16
Phui-Ly Liew, Rui-Lan Huang, Yu-Chun Weng, Chia-Lang Fang, Tim Hui-Ming Huang, Hung-Cheng Lai
Mucinous type of epithelial ovarian cancer (MuOC) is a unique subtype with a poor survival outcome in recurrent and advanced stages. The role of type-specific epigenomics and its clinical significance remain uncertain. We analyzed the methylomic profiles of six benign mucinous adenomas, 24 MuOCs, 103 serous type of epithelial ovarian cancers (SeOCs), and 337 nonepithelial ovarian cancers. MuOC and SeOC exhibited distinct DNA methylation profiles comprising 101 genes, 81 of which exhibited low methylation in MuOC and were associated with the response to glucocorticoid, ATP hydrolysis-coupled proton transport, proteolysis involved in the cellular protein catabolic process, and ion transmembrane transport...
February 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29451104/a-multi-criteria-decision-making-approach-to-rank-supplier-selection-criteria-for-hospital-waste-management-a-case-from-pakistan
#17
Palvisha Ishtiaq, Sharfuddin Ahmed Khan, Moiz-Ul Haq
To address environmental issues and cost effectiveness, waste management is necessary for healthcare facilities. Most importantly, segregation of hazardous and non-hazardous waste must be done as in many developing countries; disposal of both types of healthcare waste is done together, which is an unsafe practice. Waste generated in hospitals needs proper management to minimise hazards for patient and healthcare workers. At the same time, it is quite difficult for hospitals to find a systematic way to select appropriate suppliers for hospital waste management...
February 1, 2018: Waste Management & Research
https://www.readbyqxmd.com/read/29451060/cord-blood-buffy-coat-dna-methylation-is-comparable-to-whole-cord-blood-methylation
#18
John Dou, Rebecca J Schmidt, Kelly S Benke, Craig Newschaffer, Irva Hertz-Picciotto, Lisa A Croen, Ana-Maria Iosif, Janine M LaSalle, M Daniele Fallin, Kelly M Bakulski
Cord blood DNA methylation is associated with numerous health outcomes and environmental exposures. Whole cord blood DNA reflects all nucleated blood cell types, while centrifuging whole blood separates red blood cells, generating a white blood cell buffy coat. Both sample types are used in DNA methylation studies. Cell types have unique methylation patterns and processing can impact cell distributions, which may influence comparability. We evaluated differences in cell composition and DNA methylation between cord blood buffy coat and whole cord blood samples...
February 16, 2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29450855/health-related-quality-of-life-among-us-military-personnel-injured-in-combat-findings-from-the-wounded-warrior-recovery-project
#19
Susan I Woodruff, Michael R Galarneau, Cameron T McCabe, Daniel I Sack, Mary C Clouser
PURPOSE: Little is known about the long-term, health-related quality of life (HRQOL) of those wounded in combat during Operations Enduring Freedom, Iraqi Freedom, and New Dawn. The present study described the overall HRQOL for a large group of US service members experiencing mild-to-severe combat-related injuries, and assessed the unique contribution of demographics, service- and injury-related characteristics, and mental health factors on long-term HRQOL. METHOD: The Wounded Warrior Recovery Project examines patient-reported outcomes in a cohort of US military personnel wounded in combat...
February 15, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29450771/fetal-exposure-markers-of-dioxins-and-dioxin-like-pcbs
#20
Erik Lampa, Akifumi Eguchi, Emiko Todaka, Chisato Mori
Fetal exposure to polychlorinated biphenyls (PCBs), polychlorinated-p-dibenzodioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) have been associated with a number of adverse health outcomes. Although the placenta acts as a barrier between the mother and the fetus, these contaminants transfer through the placenta exposing the fetus. Several studies have investigated placental transfer, but few have assessed the co-variation among these contaminants. Maternal blood, cord blood, and cord tissue were collected from 41 Japanese mother-infant pairs and analyzed for dioxin-like PCBs and PCDD/Fs...
February 15, 2018: Environmental Science and Pollution Research International
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