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Sarah Saperia, Susana Da Silva, Ishraq Siddiqui, Krysta McDonald, Ofer Agid, Gary Remington, George Foussias
BACKGROUND: Previous studies have suggested that, despite marked functional impairments, remitted first episode patients with schizophrenia report levels of well-being that are comparable to healthy controls. The aim of the current study was to specifically evaluate self-reported happiness, life satisfaction and success in individuals with schizophrenia beyond their first-episode of psychosis, and to investigate the impact of symptoms and functioning on these subjective experiences. METHODS: Fifty-one schizophrenia patients and 56 matched healthy controls participated in the study...
November 22, 2017: Comprehensive Psychiatry
Wenwei Zhan, Siruo Yu, Liang Gao, Feng Wang, Xue Fu, Gang Sui, Xiaoping Yang
Nowadays, physical absorption has become a feasible method offering an efficient and green route to remove organic pollutants from the industrial wastewater. Inspired by polydopamine (PDA) chemistry, one dimensional PDA functionalized multi-walled carbon nanotubes (MWCNT-PDA) were creatively introduced into graphene aerogel framework to synthesis a robust graphene/MWCNT-PDA composite aerogel (GCPCA). The whole forming process needed no additional reducing agents, significantly reducing the contamination emissions to the environment...
December 15, 2017: ACS Applied Materials & Interfaces
Daeyong Jin, Hyunju Lee
With the increasing availability of multi-dimensional biological datasets for the same samples (i.e., gene expression, microRNAs, copy numbers, mutations, methylations), it has now become possible to systematically understand the regulatory mechanisms operating in a cancer cell. For this task, it is important to discover a set of co-expressed genes with functions, representing a so-called functional gene module, because co-expressed genes tend to be co-regulated by the same regulators, including transcription factors, microRNAs, and copy number aberrations...
2017: PloS One
Akritee Shrestha, Savannah Bergquist, Ellen Montz, Sherri Rose
OBJECTIVE: To propose nonparametric ensemble machine learning for mental health and substance use disorders (MHSUD) spending risk adjustment formulas, including considering Clinical Classification Software (CCS) categories as diagnostic covariates over the commonly used Hierarchical Condition Category (HCC) system. DATA SOURCES: 2012-2013 Truven MarketScan database. STUDY DESIGN: We implement 21 algorithms to predict MHSUD spending, as well as a weighted combination of these algorithms called super learning...
December 15, 2017: Health Services Research
Nurit Haspel, Dong Luo, Eduardo González
BACKGROUND: Understanding protein structure and dynamics is essential for understanding their function. This is a challenging task due to the high complexity of the conformational landscapes of proteins and their rugged energy levels. In particular, it is important to detect highly populated regions which could correspond to intermediate structures or local minima. RESULTS: We present a hierarchical clustering and algebraic topology based method that detects regions of interest in protein conformational space...
December 6, 2017: BMC Bioinformatics
Wencai Zhou, Salma Begum, Zhengbang Wang, Peter Krolla, Danny Wagner, Stefan Bräse, Christof Wöll, Manuel Tsotsalas
Development of surface coatings with high antimicrobial activity is urgently required to fight bacteria and other microorganisms on technical and hygiene relevant surfaces. Control over structure and topology of the surface coatings, combined with the ability to include functional molecules within the structure is crucial for optimizing their performance. Herein, we describe a novel strategy to synthesize structurally well-defined porphyrin polymer thin films via a template approach. In this approach bis-azido functionalized porphyrin molecules are preorganized within a metal-organic framework (MOF) structure...
December 15, 2017: ACS Applied Materials & Interfaces
Jinlei Wu, Baosheng Cao, Luis Rino, Yurui Fang, Li Hu, Zhenyi Zhang, Yingzhou Huang, Bin Dong
Up-conversion luminescence (UCL) from rare-earth doped oxide (RE) films has great potential for application in fields such as solar cells, bioanalysis, or display technologies. However, the relatively high phonon energy of oxide matrices usually facilitates nonradiative relaxation leading to low UCL efficiency. Herein, we report a three-layer hierarchical structure of Ag/ZnO nanowires (nw-ZnO)/RE composite films, which enhances the UCL of rare-earth doped oxide films. An optimization of the geometric structure of the composite films demonstrated an increase of UCL by up to almost two orders of magnitude in Er3+ and Tm3+ doped YbMoO4 films...
December 15, 2017: Nanoscale
Camile S Farah, Farzaneh Kordbacheh, Keziah John, Nigel Bennett, Simon A Fox
OBJECTIVE: To define molecular differences between autofluorescence and white light defined excision margins in oral potentially malignant disorders (OPMD) using transcriptome expression profiles. MATERIALS AND METHODS: Excisional biopsy specimens were taken from 11 patients at three different sites for each lesion: centre, white light margin, and autofluorescence margin. The lesions were diagnosed histopathologically as oral epithelial dysplasia, oral lichenoid dysplasia, oral lichen planus or other...
December 14, 2017: Oral Diseases
Hongzhi Liu
Two different silsesquioxane-based porous polymers (FHPPs), i.e. FHPP-1 and FHPP-2 were prepared, respectively, by changing acid scavengers from sodium bicarbonate to triethylamine in the Heck reaction between octavinylsilsesquioxane (OVS) and 1, 4-dibromotetrafluorobenzene. It was observed that defluorination occurred in the case of triethylamine. FHPP-1 possessed higher surface area of 600 m2 g-1 and a hierarchical pore structure; in contrast, FHPP-2 possessed SBET of 325 m2 g-1 and a microporous structure...
December 15, 2017: Chemistry: a European Journal
Ryoichi Arai
In multiscale structural biology, synthetic approaches are important to demonstrate biophysical principles and mechanisms underlying the structure, function, and action of bio-nanomachines. A central goal of "synthetic structural biology" is the design and construction of artificial proteins and protein complexes as desired. In this paper, I review recent remarkable progress of an array of approaches for hierarchical design of artificial proteins and complexes that signpost the path forward toward synthetic structural biology as an emerging interdisciplinary field...
December 14, 2017: Biophysical Reviews
Atsushi Nakagawa, Naoyuki Miyazaki, Akifumi Higashiura
Rice dwarf virus (RDV) of the family Reoviridae and genus Phytoreovirus, is the cause of rice dwarf disease, a major negative effector of rice production throughout East Asia, including Japan. RDV has an icosahedral double-layered shell of approximately 70 nm diameter. The structural proteins constituting the capsid can self-assemble into a correct particle without requiring the help of any external factors in vitro. A total of more than 900 components assemble to make the full particle. A series of structural and functional studies of RDV, including X-ray crystallography and cryo-electron microscopy, suggest a hierarchical self-assembly mechanism involving both homologous and heterologous interactions...
December 14, 2017: Biophysical Reviews
Dinara Sadykova, Beth E Scott, Michela De Dominicis, Sarah L Wakelin, Alexander Sadykov, Judith Wolf
Understanding spatial physical habitat selection driven by competition and/or predator-prey interactions of mobile marine species is a fundamental goal of spatial ecology. However, spatial counts or density data for highly mobile animals often (1) include excess zeros, (2) have spatial correlation, and (3) have highly nonlinear relationships with physical habitat variables, which results in the need for complex joint spatial models. In this paper, we test the use of Bayesian hierarchical hurdle and zero-inflated joint models with integrated nested Laplace approximation (INLA), to fit complex joint models to spatial patterns of eight mobile marine species (grey seal, harbor seal, harbor porpoise, common guillemot, black-legged kittiwake, northern gannet, herring, and sandeels)...
July 2017: Ecology and Evolution
Maureen Perry-Jenkins, JuliAnna Z Smith, Lauren Page Wadsworth, Hillary Paul Halpern
Little research has explored linkages between workplace policies and mental health in working-class, employed parents, creating a gap in our knowledge of work-family issues across social class levels. The current U.S. study addresses this gap by employing hierarchical linear modeling techniques to examine how workplace policies and parental leave benefits predicted parents' depressive symptoms and anxiety in a sample of 125, low-income, dual-earner couples interviewed across the transition to parenthood. Descriptive analyses revealed that, on average, parents had few workplace policies, such as schedule flexibility or child care supports, available to them...
2017: Community, Work & Family
Jian Huang, Hong-Ming Ding, Yan Xu, Dai Zeng, Hui Zhu, Dong-Mian Zang, Song-Song Bao, Yu-Qiang Ma, Li-Min Zheng
Chiral expression from the molecular to macroscopic level is common in biological systems, but is difficult to realise for coordination polymers (CPs). The assembly of homochiral CPs in both crystalline and helical forms can provide a bridge for understanding the relationship between the molecular and macroscopic scales of chirality. Herein, we report homochiral helices of [Tb(R- or S-pempH)3]∙2H2O (R - or S -1) (pempH2 = (1-phenylethylamino)methylphosphonic acid) and their crystalline counterparts (R - or S -3), which are formed at different pH of the reaction mixtures under hydrothermal conditions...
December 14, 2017: Nature Communications
Kathryn P Derose, Bing Han, Stephanie Williamson, Deborah A Cohen
INTRODUCTION: Physical inactivity is more prevalent among women than men and is related to poor health outcomes. Neighborhood parks constitute an important resource for physical activity (PA), however, previous studies of park users have found fewer women being physically active. METHODS: We conducted a hierarchical mixed-effect regression analysis of the independent associations between gender and park use and PA among a population-based sample in high-poverty neighborhoods in Los Angeles...
December 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
Eleonora C V Costa, Eva Castanheira, Litícia Moreira, Paulo Correia, Duarte Ribeiro, M Graça Pereira
BACKGROUND: Assessment and treatment of emotional distress during pregnancy show that worries during pregnancy and interpersonal relationships with partners are the important factors determining psychological health. AIMS: The present study aimed to investigate the impact of worries during pregnancy, relationship intimacy, and marital satisfaction on anxiety, depression, and stress symptoms in pregnant women, as well as to analyse the mediating effect of relationship intimacy between marital satisfaction and emotional distress...
December 15, 2017: Journal of Mental Health
Numa Joy Bertola, Maria Papadopoulou, Didier Vernay, Ian F C Smith
Assessing ageing infrastructure is a critical challenge for civil engineers due to the difficulty in the estimation and integration of uncertainties in structural models. Field measurements are increasingly used to improve knowledge of the real behavior of a structure; this activity is called structural identification. Error-domain model falsification (EDMF) is an easy-to-use model-based structural-identification methodology which robustly accommodates systematic uncertainties originating from sources such as boundary conditions, numerical modelling and model fidelity, as well as aleatory uncertainties from sources such as measurement error and material parameter-value estimations...
December 14, 2017: Sensors
Qian Wu, Li-Xiu Gong, Yang Li, Cheng-Fei Cao, Long-Cheng Tang, Lianbin Wu, Li Zhao, Guo-Dong Zhang, Shi-Neng Li, Jiefeng Gao, Yongjin Li, Yiu-Wing Mai
Design and development of smart sensors for rapid flame detection in post-combustion and early fire warning in pre-combustion situations are critically needed to improve the fire safety of combustible materials in many applications. Herein, we describe the fabrication of hierarchical coatings created by assembling a multi-layered graphene oxide (GO)/silicone structure onto different combustible substrate materials. The resulting coatings exhibit distinct temperature-response electrical resistance change as efficient early-warning sensors for detecting abnormal high environmental temperature, thus enabling fire prevention below the ignition temperature of combustible materials...
December 14, 2017: ACS Nano
Katherine A Benavides, Iain W H Oswald, Julia Y Chan
The discovery of novel magnetic and electronic properties in low-dimensional materials has led to the pursuit of hierarchical materials with specific substructures. Low-dimensional solids are highly anisotropic by nature and show promise in new quantum materials leading to exotic physical properties not realized in three-dimensional materials. We have the opportunity to extend our synthetic strategy of the flux-growth method to designing single crystalline low-dimensional materials in bulk. The goal of this Account is to highlight the synthesis and physical properties of several low-dimensional intermetallic compounds containing specific structural motifs that are linked to desirable magnetic and electrical properties...
December 14, 2017: Accounts of Chemical Research
Liangliang Tian, Gege He, Yanhua Cai, Shenping Wu, Yongyao Su, Hengqing Yan, Cong Yang, Yanling Chen, Lu Li
Inspired by kinetics, the design of hollow hierarchical electrocatalysts through large-scale integration of building blocks is recognized as an effective approach to achieve superior electrocatalytic performance. In this work, Co3O4 hollow hierarchical architecture (Co3O4 HHA) was constructed through coordinating etching and precipitating (CEP) method followed by calcination. The Co3O4 HHA electrode exhibits excellent electrocatalytic activity in terms of high sensitivity (839.3 µA mM-1 cm-2) and reliable stability towards the detection of glucose...
December 14, 2017: Nanotechnology
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